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Gallbladder carcinoma

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https://www.readbyqxmd.com/read/29776636/molecular-diagnostics-in-the-neoplasms-of-the-pancreas-liver-gallbladder-and-extrahepatic-biliary-tract-2018-update
#1
REVIEW
Lei Zhang, Martin H Bluth, Amarpreet Bhalla
Pancreatic neoplasms, including ductal adenocarcinoma, solid pseudopapillary neoplasm, pancreatic endocrine neoplasms, acinar cell carcinoma, and pancreatoblastoma, are associated with different genetic abnormalities. Hepatic adenomas with beta-catenin exon 3 mutation are associated with a high risk of malignancy. Hepatic adenoma with arginosuccinate synthetase 1 expression or sonic hedgehog mutations are associated with a risk of bleeding. Hepatocellular carcinoma and choangiocarcinoma display heterogeneity at both morphologic and molecular levels Cholangiocellular carcinoma is most commonly associated with IDH 1/2 mutations...
June 2018: Clinics in Laboratory Medicine
https://www.readbyqxmd.com/read/29742709/spontaneous-acalculous-gallbladder-perforation-in-a-man-secondary-to-chemotherapy-and-radiation-a-rare-case-report
#2
Jungang Zhang, Guoliang Shen, Ying Shi, Chengwu Zhang, Defei Hong, Li Jin, Hongguo Yang, Wei Sun, Hanhui Cai, Zhiming Hu, Weiding Wu
RATIONALE: Gallbladder perforation is a serious clinical condition and associated with high morbidity and mortality. A definitive diagnosis is contentious before surgery. PATIENT CONCERNS: We herein report a case of perforation of the gallbladder neck secondary to chemotherapy and radiation for nasopharyngeal carcinoma patient. DIAGNOSES: Gallbladder perforation secondary to chemotherapy and radiation. INTERVENTIONS: To decrease the mortality associated with gallbladder perforation, Laparoscopic cholecystectomy and peritoneal lavage were performed followed for gallbladder perforation patient because of chemotherapy and radiation...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29731799/beware-of-bone-marrow-incidental-detection-and-primary-diagnosis-of-solid-tumours-in-bone-marrow-aspiration-and-biopsies-a-study-of-22-cases
#3
Ruchita Tyagi, Aminder Singh, Bhavna Garg, Neena Sood
Background & objective: Introduction: First detection of any solid tumour as metastatic deposits in bone marrow directs clinicians to start searching for the primary tumour. Detection of bone marrow metastasis determines the stage of the malignancy, prognosis, mode of treatment, chemotherapeutic response and follow-up in case of relapse. The aim of the current study was to analyse the clinico-haematological presentation and morphological pattern of infiltration of solid tumours detected first as metastatic deposits on bone marrow examination...
2018: Iranian Journal of Pathology
https://www.readbyqxmd.com/read/29718836/gallbladder-perforation-in-a-patient-with-alcoholic-liver-cirrhosis-and-asymptomatic-gallstones-a-case-report
#4
Xiaoju Shi, Shuo Jin, Siyuan Wang, Weijie Tao, Guangyi Wang
RATIONALE: Gallbladder perforation is a relatively uncommon complication of alcoholic liver cirrhosis and may happen with or without gallstones. PATIENT CONCERNS: Here we report a 52-year-old male patient who was diagnosed as gallbladder perforation with chronic liver cirrhosis and asymptomatic gallstones. The patient was admitted with acute and severe abdominal pain during weight-bearing physical labor. He had a history of alcoholic liver cirrhosis but no chronic abdominal pain or gallstones...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29714811/gallbladder-carcinoma-an-analysis-of-the-national-cancer-data-base-to-examine-hispanic-influence
#5
Chrissy Liu, Nicholas G Berger, Lisa Rein, Sergey Tarima, Callisia Clarke, Harveshp Mogal, Kathleen K Christians, Susan Tsai, T Clark Gamblin
BACKGROUND: Gallbladder cancer (GBC) is a lethal disease with high incidence among Hispanics. Overall survival (OS) among races/ethnicities has not been described using the most recent National Cancer Database. This study hypothesized that prognosis is worse for Hispanics compared to similar non-Hispanic populations. METHODS: Patients with GBC were identified from the National Cancer Database and categorized as White, Black, Hispanic, and Other. Descriptive statistics, OS, and Cox regression were examined...
May 1, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29696323/routine-pathology-and-postoperative-follow-up-are-not-cost-effective-in-cholecystectomy-for-benign-gallbladder-disease
#6
Pim B Olthof, Madelon J H Metman, Ronald R de Krijger, Joris J Scheepers, Daphne Roos, Jan Willem T Dekker
INTRODUCTION: The incidence of gallstone disease is increasing and represents a strain on healthcare systems worldwide. Following cholecystectomy, gallbladder specimens are generally submitted for histopathologic examination and the diagnostic yield of this strategy remains questionable. This study aimed to evaluate the usefulness of routine pathologic examination of the gallbladder specimens and investigate the results of routine postoperative follow-up visits. METHODS: All cholecystectomies performed between January 2011 and July 2017 at a single center were evaluated...
April 25, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29668579/gallbladder-cancer-with-tumor-thrombus-in-the-portal-vein-a-case-report
#7
Xiao-Zhen Zhang, Jian-Jun Tu, Wei Chen, Tao Ma, Xue-Li Bai, Ting-Bo Liang
RATIONALE: Gallbladder cancer (GBC) is a highly fatal malignancy. Due to its invasiveness and delayed diagnosis, many GBC patients are diagnosed with synchronous liver and hepatoduodenal ligament involvement. In our case, we report a gallbladder cancer with portal vein thrombus. PATIENT CONCERNS: A 60-year-old woman presented with persistent upper abdominal dull pain for 2 months. DIAGNOSES: Ultrasound examination showed gallbladder carcinoma invading liver segment IV, and a tumor thrombus in the left and right main portal trunk...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29659084/hepatobiliary-and-pancreatic-a-case-of-pure-squamous-cell-carcinoma-of-the-gallbladder
#8
M Kobayashi, S Ryozawa, K Nagata
No abstract text is available yet for this article.
May 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29650922/-gallbladder-carcinoma-that-occurred-50-years-after-cholecystojejunostomy
#9
Masaru Kubota, Yasuji Hashimoto, Hiroki Imamura, Yuriko Yagi, Takashi Noma, Yukako Mokutani, Kenichi Nagai, Hajime Hirose, Yoshihito Ide, Jin Matsuyama, Yukio Fukushima, Yousuke Nishioka, Masashi Takeda, Shigeyuki Tamura, Yo Sasaki
Creation of a cholecystojejunostomy has been recommended as one option in the palliation of biliary obstruction due to pancreatic carcinoma.However, it was a technique used for biliary drainage for acute cholecystitis a long time ago.We describe a patient who underwent a cholecystojejunostomy for acute cholecystitis 50 years prior to presentation, and then revealed a gallbladder carcinoma.
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650819/-a-case-report-of-neuroendocrine-carcinoma-in-the-gall-bladder-showing-recurrence-shortly-after-surgery
#10
Yoshihiro Uchino, Sonofu Taketani, Nobuhisa Hirayu, Koji Shiota, Hironobu Sou, Satoshi Taniwaki, Tetsuo Imamura
A55 -year-old woman with a 10×8mm protuberant gallbladder lesion visited our hospital. To determine possible malignancy, she underwent laparoscopic excision biopsy of the gallbladder, and pathological findings revealed an endocrine carcinoma in the gallbladder. Surgery involved extrahepatic bile duct resection, gallbladder bed resection, and hepatic portal lymph node resection. Recurrence in the peritoneal lymph node was observed in the early postoperative period. Chemotherapy was initiated with cisplatin and irinotecan, and continues 18 months post-operatively...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29642951/use-of-oxidized-regenerated-cellulose-to-achieve-hemostasis-during-laparoscopic-cholecystectomy-a-retrospective-cohort-analysis
#11
Emilia Masci, Giuseppe Faillace, Mauro Longoni
OBJECTIVE: Laparoscopic cholecystectomy is the first-choice treatment for symptomatic cholelithiasis. Though generally safe, this procedure is not without complications, with bleeding the most frequent cause of conversion to open cholecystectomy. Oxidized regenerated cellulose (ORC) added to conventional hemostatic strategies, is widely used to control bleeding during surgery despite limited evidence supporting its use. This retrospective study analyzed patients undergoing laparoscopic cholecystectomy in an Italian center over a 16-month period, between October 2014 and February 2016, who experienced uncontrollable bleeding despite the use of conventional hemostatic strategies, requiring the addition of ORC gauze (Emosist® )...
April 11, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29626304/efficacy-of-the-gallbladder-cancer-predictive-risk-score-based-on-pathological-findings-a-propensity-score-matched-analysis
#12
Tetsuya Mochizuki, Tomoyuki Abe, Hironobu Amano, Keiji Hanada, Minoru Hattori, Tsuyoshi Kobayashi, Masahiro Nakahara, Hideki Ohdan, Toshio Noriyuki
BACKGROUND: The optimal prognostic predictive system for gallbladder carcinoma (GBC) has not been established. The gallbladder cancer predictive risk score (GBRS) based on pathological findings identifies incidental GBC patients at risk of recurrence. OBJECTIVE: We aimed to validate the prognostic ability of the GBRS in all GBC patients following curative surgery. METHODS: Fifty-six patients with GBC who underwent curative surgery between 1996 and 2016 were included in this study...
April 6, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29624208/gemcitabine-based-chemotherapy-for-advanced-biliary-tract-carcinomas
#13
REVIEW
Omar Abdel-Rahman, Zeinab Elsayed, Hesham Elhalawani
BACKGROUND: Biliary tract cancers are a group of rare heterogeneous malignant tumours. They include intrahepatic and extrahepatic cholangiocarcinomas, gallbladder carcinomas, and ampullary carcinomas. Surgery remains the optimal modality of therapy leading to long-term survival for people diagnosed with resectable biliary tract carcinomas. Unfortunately, most people with biliary tract carcinomas are diagnosed with either unresectable locally-advanced or metastatic disease, and they are only suitable for palliative chemotherapy or supportive care...
April 6, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29623349/three-cases-of-intracystic-papillary-neoplasm-of-gallbladder
#14
Naruki Mizobuchi, Jiro Munechika, Nobuyuki Takeyama, Yoshimitsu Ohgiya, Nobuyuki Ohike, Ryosuke Abe, Noritsugu Takahama, Osamu Miyagami, Kumi Hatano, Kumiko Ishizuka, Masanori Hirose, Takehiko Gokan
Intracystic papillary neoplasm (ICPN) of gallbladder is a comparatively new concept and is described as pre-malignant lesions in Nakanuma et al. (In: Bosman et al. (eds) WHO Classification of Tumours of the Digestive System, World Health Organization of Tumours, IARC, Lyon, 2010). ICPN with high-grade intraepithelial neoplasia is understood to include intraepithelial carcinoma or noninvasive carcinoma. And lesions with invasive cancer components are classified as ICPN with an associated invasive carcinoma [1]...
April 6, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29600228/incidental-gallbladder-carcinoma-utility-of-histopathological-evaluation-of-routine-cholecystectomy-specimens
#15
Vidya Jha, Preeti Sharma, K Ashish Mandal
Background: Incidental gallbladder carcinoma (IGBC) is rare cancer diagnosed during or after cholecystectomy done for benign gallbladder disease. The concern whether routine histopathological examination is needed for all cholecystectomy specimens still remains debatable. Materials and Methods: Twenty patients diagnosed with IGBC over a period of 2 years were retrospectively reviewed. Clinical details including clinical presentation, preoperative ultrasound (USG) findings, and macroscopic features were retrieved...
January 2018: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/29598788/gene-silencing-of-heparanase-results-in-suppression-of-invasion-and-migration-of-gallbladder-carcinoma-cells
#16
Hao Jin, Min Cui
This study investigated the effect of transcriptional gene silencing of the heparanase gene on standard gallbladder carcinoma cells (GBC-SD). The miRNAs targeting the promoter region and coding region of the heparanase gene were designed and synthesized. We transfected four recombinant miRNA vectors into GBC-SD. We performed the wound healing assays and invasion assays. The result shows that the heparanase expression was significantly decreased by recombinant vectors in transfected GBC-SD cells (p < 0...
March 29, 2018: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29596949/epidemiological-dimensions-of-the-association-between-type-2-diabetes-and-cancer-a-review-of-observational-studies
#17
REVIEW
Carlotta Sacerdote, Fulvio Ricceri
Type 2 diabetes (T2D) is a major cause of complications and death in many countries. The possible causal relation between T2D and cancer has been the aim of many research investigations. In view of the importance of the topic we carried out a narrative review of observational studies to summarize the available evidence of the association between T2D and cancer. To deal with the problem of abundance of published studies, we reviewed up to December 2017, the literature of meta-analyses of observational studies first, then we reviewed cohort studies not reported in meta-analyses because of more recent publication...
March 27, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29594465/interpreting-body-mri-cases-classic-findings-in-abdominal-mri
#18
REVIEW
Leann Kania, Flavius Guglielmo, Donald Mitchell
Few things in radiology are "pathognomonic" in their appearance or presentation. However, having an awareness of those findings which are specific to a certain entity is important when interpreting imaging studies. These classic findings can be identified with many imaging modalities, but no modality provides as many recognizable observations as an MRI. This results from the large variety of pulse sequences that provide high contrast resolution, prior to and following contrast administration. In this article, the most classically recognized abdominal findings are presented including the following: Liver: Cyst, hemangioma, focal nodular hyperplasia, hepatic adenoma, hemosiderosis, hepatocellular carcinoma...
March 28, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29589676/gallbladder-neuroendocrine-carcinoma-metastasis-or-synchronous-tumor
#19
Adriana Handra-Luca
No abstract text is available yet for this article.
March 28, 2018: Minerva Chirurgica
https://www.readbyqxmd.com/read/29578186/contrast-enhanced-ultrasound-imaging-characteristics-of-malignant-transformation-of-a-localized-type-gallbladder-adenomyomatosis-a-case-report-and-literature-review
#20
Xiao-Chen Shi, Shao-Shan Tang, Wei Zhao
Gallbladder adenomyomatosis (GAM) is an acquired, reactive, tumor-like condition. Malignant transformation is extremely rare, and imaging features during contrast-enhanced ultrasound (CEUS) have not been described before. Herein, we describe a 73-year-old Asian man who had been diagnosed with gallbladder carcinoma by conventional ultrasonography (US). Based on additional radiological findings, we believed that it was a localized adenomyomatosis. However, the histopathological diagnosis was adenocarcinoma originate from adenomyomatosis with serosal invasion...
2018: Journal of Cancer Research and Therapeutics
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