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Undifferentiated carcinoma with osteoclast like giant cells

Hiroyuki Saito, Hiroshi Kashiyama, Takashi Murohashi, Kazunari Sasaki, Ryosuke Misawa, Susumu Ohwada
Undifferentiated carcinoma of the pancreas (UDC) is rare and has a dismal prognosis. Here, we report a case of 6-year disease-free survival with a mixed type of UDC and UDC with osteoclast-like giant cells, with a high mitotic index as well as perineural, lymphatic, vessel, and diaphragmatic invasion. The patient underwent radical distal pancreatectomy and was subsequently treated with adjuvant chemotherapy using gemcitabine plus S-1 followed by maintenance chemotherapy with oral tegafur-uracil. The patient has been doing well with no evidence of recurrence for more than 6 years after surgery...
May 2016: Case Reports in Gastroenterology
Yusuke Kawamoto, Yusuke Ome, Kazuhiro Terada, Kazuki Hashida, Kazuyuki Kawamoto, Tadashi Ito
INTRODUCTION: Undifferentiated carcinomas with osteoclast-like giant cells (UC-OGCs) of the ampullary region are very rare, with only a few cases reported to date. The clinicopathological features, treatment options, and prognosis of UC-OGCs are unclear. This report describes a patient with UC-OGCs of the ampullary region. PRESENTATION OF CASE: A 78-year-old male patient was admitted for epigastric pain and fever. Contrast-enhanced computed tomography revealed a 2...
2016: International Journal of Surgery Case Reports
Georgios Κ Georgiou, Ephimia Balasi, Vasiliki Siozopoulou, Athina Tsili, Michalis Fatouros, Georgios Glantzounis
INTRODUCTION: Undifferentiated head of pancreas carcinoma with osteoclast-like giant cells (UC-OGC) is a rare neoplasm, with less than a hundred cases reported. We present such a case, in which the UC-OGC presented atypically as a cystic lesion following acute pancreatitis and led to late diagnosis. PRESENTATION OF CASE: A 75-year-old female patient, who had suffered acute pancreatitis three years ago, was referred with a diagnosis of osteoclast-like giant cell (OGC) tumor of the head of pancreas...
2016: International Journal of Surgery Case Reports
Lingchen Kong, Wenhong Peng, Jing Liu, Wei Wang, Peiyou Gong, Guohua Yu, Junxia Li
Resently, we treated a 69-year-old patient with squamous cell carcinoma of lung with osteoclast-like giant cells which were similar with the giant cell tumor of bone. The clinical and pathological characteristics of this case were presented, and the literatures were reviewed. The tumor differed histologically from the pleomorphic carcinoma, which occurs most commonly in the lung and showed diverse pleomorphic manifestation with benign looking osteoclast-like multinucleated cells and bizarre giant cells. In addition, undifferentiated carcinoma with a sarcoma-like appearance containing small areas of papillary adenocarcinoma was evident in the tumor...
2015: International Journal of Clinical and Experimental Pathology
Shambhu K Sah, Ying Li, Yongmei Li
Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells (UCPOGC) is an extremely rare non-endocrine pancreatic tumor. To date, some cases have been reported, however, histogenesis and biologic behavior of UCPOGC remain controversial. We report a case of an UCPOGC in a 54-year-old female, who presented with a three-month history of recurrent abdominal pain without any incentive. Abdominal computed tomography (CT) revealed a large cystic mass of 10.5 × 9.3 cm in the body and tail of the pancreas compressing the adjacent bowel loop and stomach...
2015: International Journal of Clinical and Experimental Pathology
Marco Chiarelli, Angelo Guttadauro, Martino Gerosa, Alessandro Marando, Francesco Gabrielli, Matilde De Simone, Ugo Cioffi
BACKGROUND: Only few case reports of mucinous cystic pancreatic neoplasm containing an undifferentiated carcinoma with osteoclast-like giant cells have been described in the literature. In the majority of cases this unusual association of tumors seems related to a favorable outcome. We present the second case of an indeterminate mucin-producting cystic neoplasm containing an area of carcinoma with osteoclast-like giant cells. The specific features of the two histotypes and the rapid course of the disease make our clinical case remarkable...
2015: BMC Gastroenterology
Kyung Yoon Yang, Joon-Il Choi, Moon Hyung Choi, Michael Yong Park, Sung Eun Rha, Jae Young Byun, Eun Sun Jung, Chandana Lall
Undifferentiated carcinoma with osteoclast-like giant cells is a rare pancreatic and periampullary neoplasm with less than 50 cases reported in the literature. Pathologically, this tumor mimics a giant cell tumor in bones. We report a case of undifferentiated carcinoma with osteoclast-like giant cells in a 55-year-old man presenting as a pancreatic mass with associated regional and distant lymphadenopathy. On T1- and T2-weighted images, the mass shows dark signal intensity which was atypical for a pancreatic adenocarcinoma...
January 2016: Clinical Imaging
Hans Helmut Dahm
BACKGROUND: Malignant liver tumors with osteoclast-like giant cells are rare. A literature search showed 17 previously reported cases that included the following: (1) 8 undifferentiated hepatocellular carcinomas, (2) 5 sarcomatous tumors with osteoclast-like giant cells associated with intrahepatic cholangiocarcinoma or liver cystadenocarcinoma, and (3) 4 sarcomatoid tumors with osteoclast-like giant cells associated with areas of a conventional hepatocellular carcinoma. CASE PRESENTATION: A 68-year-old man presented with a tumor of the right lobe of the liver on ultrasonography and computed tomography...
2015: Diagnostic Pathology
Hong-Qiao Gao, Yin-Mo Yang, Yan Zhuang, Ping Liu
Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas (UCOGCP) is an unusual pancreatic neoplasm that represents < 1% of all pancreatic malignancies. Moreover, the giant cells of UCOGCP morphologically resemble the benign giant cells of bone tumors. Due to the rarity of this tumor type, the histogenesis and biologic behavior of UCOGCP remain controversial. Here, we report a case of UCOGCP that exhibited an invasive growth pattern involving infiltration of the adjacent bowel loop and portal vein, as well as superior mesenteric vein thrombosis...
January 14, 2015: World Journal of Gastroenterology: WJG
Aatur D Singhi, Raja R Seethala, Katie Nason, Tyler J Foxwell, Robyn L Roche, Kevin M McGrath, Ryan M Levy, James D Luketich, Jon M Davison
Undifferentiated carcinoma of the esophagus is a rare histologic variant of esophageal carcinoma. Using criteria based on studies of undifferentiated carcinomas arising at other sites, we have collected 16 cases of resected esophageal undifferentiated carcinomas. Patients ranged in age from 39 to 84 years (mean, 65.5 years) and were predominantly male (94%). The tumors were characterized by an expansile growth pattern of neoplastic cells organized in solid sheets and without significant glandular, squamous, or neuroendocrine differentiation...
March 2015: Human Pathology
Kee-Taek Jang, Sang Mo Park, Olca Basturk, Pelin Bagci, Sudeshna Bandyopadhyay, Edward B Stelow, Dustin M Walters, Dong Wook Choi, Seoung Ho Choi, Jin Seok Heo, Juan M Sarmiento, Michelle D Reid, Volkan Adsay
Information on the clinicopathologic characteristics of invasive carcinomas arising from mucinous cystic neoplasms (MCNs) is limited, because in many early studies they were lumped and analyzed together with noninvasive MCNs. Even more importantly, many of the largest prior studies did not require ovarian-type stroma (OTS) for diagnosis. We analyzed 178 MCNs, all strictly defined by the presence of OTS, 98% of which occurred in perimenopausal women (mean age, 47 y) and arose in the distal pancreas. Twenty-nine (16%) patients had associated invasive carcinoma, and all were female with a mean age of 53...
February 2015: American Journal of Surgical Pathology
Naoto Kuroda, Takushi Naroda, Masato Tamura, Delia Perez-Montiel, Michal Michal, Ondrej Hes
In this article, we present a rare case of renal pelvic carcinoma. The imaging examination of a 75-year-old Japanese man disclosed the left renal pelvic tumor. The histological examination showed the finding of predominant undifferentiated discohesive mononuclear cells with abundant osteoclast-like giant cells and a minor component of papillary urothelial carcinoma. Rhabdoid morphology was focally seen. Immunohistochemically, mononuclear cells were focally positive for thrombomodulin and showed a high MIB-1 index, whereas osteoclast-like giant cells were positive for CD68...
October 2014: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
Shinjiro Kobayashi, Hiroshi Nakano, Nobuyuki Ooike, Masaki Oohashi, Satoshi Koizumi, Takehito Otsubo
An undifferentiated carcinoma with osteoclast-like giant cell tumors (UC-OGC) is a rare type of tumor, which predominantly occurs in the pancreas. Due to the rarity of UC-OGC, sufficient clinical data are not available and its prognosis following surgical resection remains unclear. In the current report the case of a 37-year-old female is presented, in whom an UC-OGC of the pancreas was removed and following this, a second carcinoma of the remnant pancreas was removed during a second surgical procedure. At the patient's initial admission, the preoperative images demonstrated a well-demarcated mass with a marked cystic component at the pancreatic head...
October 2014: Oncology Letters
Abbas Agaimy, Florian Haller, Judith Frohnauer, Inga-Marie Schaefer, Philipp Ströbel, Arndt Hartmann, Robert Stoehr, Günter Klöppel
Pancreatic undifferentiated carcinoma is a heterogeneous group of neoplasms, including pleomorphic giant cell, sarcomatoid, round cell, and rhabdoid carcinomas, the molecular profiles of which have so far been insufficiently characterized. We studied 14 undifferentiated carcinomas with prominent rhabdoid cells, occurring as advanced tumors in seven females and seven males aged 44-96 years (mean: 65 years). Histologically, 10 tumors qualified as pleomorphic giant cell and 4 as monomorphic anaplastic carcinomas...
February 2015: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
Wudneh M Temesgen, Mitchell Wachtel, Sharmila Dissanaike
INTRODUCTION: Pancreatic giant cell tumors are rare, with an incidence of less than 1% of all pancreatic tumors. Osteoclastic giant cell tumor (OGCT) of the pancreas is one of the three types of PGCT, which are now classified as undifferentiated carcinoma with osteoclast-like giant cells. PRESENTATION OF CASE: The patient is a 57 year old woman who presented with a 3 week history of epigastric pain and a palpable abdominal mass. Imaging studies revealed an 18cm×15cm soft tissue mass with cystic components which involved the pancreas, stomach and spleen...
2014: International Journal of Surgery Case Reports
Sungho Jo
Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells (OGCs) is very rare, less than 1% of all pancreatic malignancies, and shows worse prognosis than that of invasive ductal adenocarcinoma of the pancreas. We present a case of en bloc resection for a huge undifferentiated carcinoma with OGCs that invaded the stomach and transverse mesocolon. A 67-year female was admitted for left upper quadrant pain and computed tomography demonstrated a mass occupying the lesser sac and abutting the stomach and pancreas...
March 14, 2014: World Journal of Gastroenterology: WJG
Noureddine Njoumi, Faricha Hassan Elalami, Gilles Attolou, Omar Saoud, Mohamed Elabsi, Mahjoub Echarrab, Mohamed Elouannani, Abdelkader Errougani, Mohamed Amraoui, Mohamed Rachid Chkoff
No abstract text is available yet for this article.
December 2014: Journal of Gastrointestinal Cancer
Hyo Jun Park, Kee-Taek Jang, Dong Wook Choi, Jin Seok Heo, Seong Ho Choi
BACKGROUND: Undifferentiated carcinoma (UC) of the gallbladder (GB) is a rare malignant neoplasm and there have only been sparse case reports without precise description. We analyzed eight cases of UC of GB and compared with gallbladder carcinoma (GBC) in the aspects of clinicopathologic characteristics and prognosis. METHODS: We found eight UC cases out of 238 surgically resected GBCs. Patients with stage-matched GBC were selected (1:4) for comparative analysis of the clinicopathologic features and survival of UC...
January 2014: Journal of Hepato-biliary-pancreatic Sciences
Vani Krishnamurthy, Sheela Devi C Shivalingiah, Sunila Ravishankar, Gubbanna V Manjunath
Carcinosarcoma is a rare tumor composed of variable proportions of carcinomatous and sarcomatous elements and comprises less than one percent of all gallbladder malignancies. In most reported cases of carcinosarcoma of gallbladder, the epithelial component is adenocarcinoma. The mesenchymal component varies from homogenous sarcoma to more heterotopic elements like malignant bone, cartilage, and other mesenchymal tissues. We report a rare case of carcinosarcoma of the gallbladder in an 83-year-old male, with the carcinomatous component represented by undifferentiated carcinoma (spindle and giant cell type with osteoclastic giant cells) and the mesenchymal component seen as foci of chondrosarcoma...
2011: Case Reports in Pathology
Masato Yoshioka, Hiroshi Uchinami, Go Watanabe, Tomokazu Takahashi, Yasuhiko Nakagawa, Hideaki Andoh, Toshiaki Yoshioka, Hiroshi Nanjo, Yuzo Yamamoto
A 74-year-old woman had an undifferentiated carcinoma with osteoclast-like giant cells (UCWOGC) in the body of the pancreas with massive portal vein tumor thrombus (PVTT). Because the PVTT progressed so rapidly into the right portal branch, the patient first underwent distal pancreatectomy and tumor thrombectomy to prevent life-threatening portal venous obstruction. Although a recurrent PVTT had developed early postoperatively, systemic gemcitabine treatment was so effective that it induced complete remission 5 months after the initiation of chemotherapy...
2012: Internal Medicine
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