Hiroshi Imaoka, Masafumi Ikeda, Kumiko Umemoto, Yu Sunakawa, Makoto Ueno, Hideki Ueno, Masato Ozaka, Takamichi Kuwahara, Naohiro Okano, Masashi Kanai, Terumasa Hisano, Yuko Suzuki, Akinori Asagi, Kazuhiko Shioji, Akiko Todaka, Kunihiro Tsuji, Kenji Ikezawa, Ikuya Miki, Yoshito Komatsu, Noriyuki Akutsu, Tatsuya Yamashita, Hiroyuki Okuyama, Junji Furuse, Hiroaki Nagano
Undifferentiated carcinoma (UC) of the pancreas is a rare subtype of pancreatic cancer displaying no definitive direction of differentiation. UC has been reported as a highly aggressive malignant neoplasm, with a median overall survival of <1 year, except for several surgical series. On the other hand, UC tissue sometimes contains non-neoplastic osteoclast-like giant cells (OGCs), and such cases have been reported to have relatively longer survival. Thus, the World Health Organization (WHO) classification histologically distinguishes UC with OGCs (UCOGCs) from UC, and UCs were subclassified into three subtypes: anaplastic UC, sarcomatoid UC and carcinosarcoma...
June 15, 2023: Japanese Journal of Clinical Oncology