keyword
https://read.qxmd.com/read/38543287/ampk-activation-by-cimicifuga-racemosa-extract-ze-450-is-associated-with-metabolic-effects-and-cellular-resilience-against-age-related-pathologies-in-different-tissue-cell-types
#1
JOURNAL ARTICLE
Madeline Günther, Peter Schnierle, Thorsten Rose, Jonathan Schlegel, Georg Boonen, Jürgen Drewe, Eduardo Muñoz, Bernd L Fiebich, Carsten Culmsee
Cimicifuga racemosa extracts (CREs) have gained well-established use for the treatment of menopausal symptoms such as hot flushes and excessive sweating, and weight gain. While the clinical effects of CREs have been well documented, the mechanisms underlying these effects are largely unknown. More recently, the metabolic effects of the CRE Ze 450 were demonstrated in cultured cells in vitro and in mouse models of obesity in vivo. At the molecular level, metabolic regulation, enhanced insulin sensitivity, and increased glucose uptake were linked to the activation of AMP-activated protein kinase (AMPK)...
March 13, 2024: Pharmaceutics
https://read.qxmd.com/read/38536913/cardiac-tissue-model-of-immune-induced-dysfunction-reveals-the-role-of-free-mitochondrial-dna-and-the-therapeutic-effects-of-exosomes
#2
JOURNAL ARTICLE
Rick Xing Ze Lu, Naimeh Rafatian, Yimu Zhao, Karl T Wagner, Erika L Beroncal, Bo Li, Carol Lee, Jingan Chen, Eryn Churcher, Daniel Vosoughi, Chuan Liu, Ying Wang, Andrew Baker, Uriel Trahtemberg, Bowen Li, Agostino Pierro, Ana C Andreazza, Claudia C Dos Santos, Milica Radisic
Despite tremendous progress in the development of mature heart-on-a-chip models, human cell-based models of myocardial inflammation are lacking. Here, we bioengineered a vascularized heart-on-a-chip with circulating immune cells to model severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced acute myocarditis. We observed hallmarks of coronavirus disease (COVID-19)-induced myocardial inflammation, as the presence of immune cells augmented the secretion of proinflammatory cytokines, triggered progressive impairment of contractile function, and altered intracellular calcium transients...
March 29, 2024: Science Advances
https://read.qxmd.com/read/38509085/lactobacillus-rhamnosus-gg-ameliorates-hyperuricemia-in-a-novel-model
#3
JOURNAL ARTICLE
Yang Fu, Yong-Song Chen, Dai-Yang Xia, Xiao-Dan Luo, Hao-Tong Luo, Jie Pan, Wei-Qing Ma, Jin-Ze Li, Qian-Yuan Mo, Qiang Tu, Meng-Meng Li, Yue Zhao, Yu Li, Yi-Teng Huang, Zhi-Xian Chen, Zhen-Jun Li, Lukuyu Bernard, Michel Dione, You-Ming Zhang, Kai Miao, Jian-Ying Chen, Shan-Shan Zhu, Jie Ren, Ling-Juan Zhou, Xian-Zhi Jiang, Juan Chen, Zhen-Ping Lin, Jun-Peng Chen, Hui Ye, Qing-Yun Cao, Yong-Wen Zhu, Lin Yang, Xue Wang, Wen-Ce Wang
Hyperuricemia (HUA) is a metabolic syndrome caused by abnormal purine metabolism. Although recent studies have noted a relationship between the gut microbiota and gout, whether the microbiota could ameliorate HUA-associated systemic purine metabolism remains unclear. In this study, we constructed a novel model of HUA in geese and investigated the mechanism by which Lactobacillus rhamnosus GG (LGG) could have beneficial effects on HUA. The administration of antibiotics and fecal microbiota transplantation (FMT) experiments were used in this HUA goose model...
March 20, 2024: NPJ Biofilms and Microbiomes
https://read.qxmd.com/read/38378577/virome-diversity-shaped-by-genetic-evolution-and-ecological-landscape-of-haemaphysalis-longicornis
#4
JOURNAL ARTICLE
Run-Ze Ye, Yu-Yu Li, Da-Li Xu, Bai-Hui Wang, Xiao-Yang Wang, Ming-Zhu Zhang, Ning Wang, Wan-Ying Gao, Cheng Li, Xiao-Yu Han, Li-Feng Du, Luo-Yuan Xia, Ke Song, Qing Xu, Jing Liu, Nuo Cheng, Ze-Hui Li, Yi-Di Du, Hui-Jun Yu, Xiao-Yu Shi, Jia-Fu Jiang, Yi Sun, Xiao-Ming Cui, Shu-Jun Ding, Lin Zhao, Wu-Chun Cao
BACKGROUND: Haemaphysalis longicornis is drawing attentions for its geographic invasion, extending population, and emerging disease threat. However, there are still substantial gaps in our knowledge of viral composition in relation to genetic diversity of H. longicornis and ecological factors, which are important for us to understand interactions between virus and vector, as well as between vector and ecological elements. RESULTS: We conducted the meta-transcriptomic sequencing of 136 pools of H...
February 21, 2024: Microbiome
https://read.qxmd.com/read/38378566/topical-rhubarb-charcoal-crosslinked-chitosan-silk-fibroin-sponge-scaffold-for-the-repair-of-diabetic-ulcers-improves-hepatic-lipid-deposition-in-db-db-mice-via-the-ampk-signalling-pathway
#5
JOURNAL ARTICLE
Qi Tan, Qifeng He, Ze Peng, Xin Zeng, Yuzhe Liu, Dong Li, Shang Wang, Jianwei Wang
BACKGROUND: Type 2 diabetes mellitus (T2DM) is closely linked to metabolic syndrome, characterised by insulin resistance, hyperglycaemia, abnormal lipid metabolism, and chronic inflammation. Diabetic ulcers (DUs) comprise consequential complications that arise as a result of T2DM. To investigate, db/db mice were used for the disease model. The findings demonstrated that a scaffold made from a combination of rhubarb charcoal-crosslinked chitosan and silk fibroin, designated as RCS/SF, was able to improve the healing process of diabetic wounds in db/db mice...
February 20, 2024: Lipids in Health and Disease
https://read.qxmd.com/read/38327186/mitochondrial-deoxyguanosine-kinase-is-required-for-female-fertility-in-mice
#6
JOURNAL ARTICLE
Yake Gao, Rui Dong, Jiacong Yan, Huicheng Chen, Lei Sang, Xinyi Yao, Die Fan, Xin Wang, Xiaoyuan Zuo, Xu Zhang, Shengyu Yang, Ze Wu, Jianwei Sun
Mitochondrial homeostasis plays a pivotal role in oocyte maturation and embryonic development. Deoxyguanosine kinase (DGUOK) is a nucleoside kinase that salvages purine nucleosides in mitochondria and is critical for mitochondrial DNA replication and homeostasis in non-proliferating cells. Dguok loss-of-function mutations and deletions lead to hepatocerebral mitochondrial DNA deletion syndrome. However, its potential role in reproduction remains largely unknown. In this study, we find that Dguok knockout results in female infertility...
February 7, 2024: Acta Biochimica et Biophysica Sinica
https://read.qxmd.com/read/38313851/body-composition-and-metabolic-syndrome-in-patients-with-type-1-diabetes
#7
JOURNAL ARTICLE
Qiong Zeng, Xiao-Jing Chen, Yi-Ting He, Ze-Ming Ma, Yi-Xi Wu, Kun Lin
BACKGROUND: In recent years, the prevalence of obesity and metabolic syndrome in type 1 diabetes (T1DM) patients has gradually increased. Insulin resistance in T1DM deserves attention. It is necessary to clarify the relationship between body composition, metabolic syndrome and insulin resistance in T1DM to guide clinical treatment and intervention. AIM: To assess body composition (BC) in T1DM patients and evaluate the relationship between BC, metabolic syndrome (MS), and insulin resistance in these indi-viduals...
January 15, 2024: World Journal of Diabetes
https://read.qxmd.com/read/38297016/toripalimab-plus-capecitabine-in-the-treatment-of-patients-with-residual-nasopharyngeal-carcinoma-a-single-arm-phase-2-trial
#8
JOURNAL ARTICLE
Xun Cao, Hao-Yang Huang, Chi-Xiong Liang, Zhuo-Chen Lin, Jia-Yu Zhou, Xi Chen, Ying-Ying Huang, Ze-Jiang Zhan, Liang-Ru Ke, Lu-Jun Han, Wei-Xiong Xia, Lin-Quan Tang, Shan-Shan Guo, Hu Liang, Xiang Guo, Xing Lv
Patients with residual nasopharyngeal carcinoma after receiving definitive treatment have poor prognoses. Although immune checkpoint therapies have achieved breakthroughs for treating recurrent and metastatic nasopharyngeal carcinoma, none of these strategies have been assessed for treating residual nasopharyngeal carcinoma. In this single-arm, phase 2 trial, we aimed to evaluate the antitumor efficacy and safety of toripalimab (anti-PD1 antibody) plus capecitabine in patients with residual nasopharyngeal carcinoma after definitive treatment (ChiCTR1900023710)...
January 31, 2024: Nature Communications
https://read.qxmd.com/read/38289948/ripk1-activation-in-mecp2-deficient-microglia-promotes-inflammation-and-glutamate-release-in-rtt
#9
JOURNAL ARTICLE
Ze Cao, Xia Min, Xingxing Xie, Maoqing Huang, Yingying Liu, Weimin Sun, Guifang Xu, Miao He, Kaiwen He, Ying Li, Junying Yuan
Rett syndrome (RTT) is a devastating neurodevelopmental disorder primarily caused by mutations in the methyl-CpG binding protein 2 (Mecp2) gene. Here, we found that inhibition of Receptor-Interacting Serine/Threonine-Protein Kinase 1 (RIPK1) kinase ameliorated progression of motor dysfunction after onset and prolonged the survival of Mecp2-null mice. Microglia were activated early in myeloid Mecp2-deficient mice, which was inhibited upon inactivation of RIPK1 kinase. RIPK1 inhibition in Mecp2-deficient microglia reduced oxidative stress, cytokines production and induction of SLC7A11, SLC38A1, and GLS, which mediate the release of glutamate...
February 6, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38253876/irritable-bowel-syndrome-in-children-the-placebo-response-rate-and-influencing-factors-a-meta-analysis
#10
Li-Li Cai, Xuan Li, Qiu-Han Cai, Sheng-Xuan Guo, Yi Zhang, Wen-Cong Sun, Ze-Hui Zhao, Si-Yuan Hu
BACKGROUND: Irritable bowel syndrome is common in children and exhibits a high placebo response. This study was to explore the placebo response rate and its influencing factors in children with irritable bowel syndrome. METHODS: A systematic search was performed on Pubmed, Embase, MEDLINE, Cochrane Library, CNKI, Wanfang, and CBM from database inception to March 2022. Randomized controlled trials of irritable bowel syndrome in children were included in the study...
January 22, 2024: Pediatric Research
https://read.qxmd.com/read/38230882/metabolic-syndrome-its-components-and-gastrointestinal-cancer-risk-a-meta-analysis-of-31-prospective-cohorts-and-mendelian-randomization-study
#11
REVIEW
Zhi-Qing Zhan, Ying-Zhou Chen, Ze-Min Huang, Yu-Hua Luo, Jia-Jian Zeng, Ye Wang, Juan Tan, Ying-Xuan Chen, Jing-Yuan Fang
BACKGROUND AND AIM: Cohort studies have linked metabolic syndrome (MetS) to gastrointestinal (GI) cancer risk. We aimed to evaluate the associations between MetS, its components, and combinations of MetS components with eight GI cancers risk. METHODS: We conducted a systematic search of prospective cohort studies and performed a meta-analysis. Subgroup analyses regarding diagnostic criteria, sex, cancer sites, histological subtypes, ethnic groups, and studies adjusted for alcohol consumption were carried out...
January 17, 2024: Journal of Gastroenterology and Hepatology
https://read.qxmd.com/read/38212038/-meta-analysis-and-trial-sequential-analysis-of-compound-qinlan-oral-liquid-in-treatment-of-acute-upper-respiratory-tract-infection
#12
JOURNAL ARTICLE
Ni Zhong, Wen-Hao Gong, Tong Wan, Rong Feng, Zhi-Fei Li, Ze-Qi Cai, Jun-Yuan Gan, Jun Ai
This study aims to evaluate the efficacy and safety of Compound Qinlan Oral Liquid in the treatment of acute upper respiratory tract infection. Computer-based online searching of CNKI, VIP, SinoMed, Wanfang, ChiCTR, ClinicalTrials.gov, Cochrane Library, PubMed, EMbase, and Web of Science was performed to retrieve the randomized controlled trial(RCT) regarding Compound Qinlan Oral Liquid in the treatment of acute upper respiratory tract infection. In addition, manual searching of gray literature was conducted...
December 2023: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://read.qxmd.com/read/38191455/the-association-between-plasma-free-amino-acids-and-type-2-diabetes-mellitus-complicated-with-infection-in-chinese-patients
#13
JOURNAL ARTICLE
Jing-Xi Zhang, Wei-Ming Luo, Bo-Wen Wang, Ru-Tao Li, Qian Zhang, Xiang-Yu Zhang, Zhong-Ze Fang, Zhi-Peng Zhang
BACKGROUND: Type 2 diabetes mellitus (T2DM), one of the most common public diseases threatening human health, is always accompanied by infection. Though there are still a variety of flaws in the treatment of some infectious diseases, metabolomics provides a fresh perspective to explore the relationship between T2DM and infection. Our research aimed to investigate the association between plasma free amino acids (PFAAs) and T2DM complicated with infection in Chinese patients. METHODS: A cross-sectional study was conducted from May 2015 to August 2016...
January 9, 2024: Diabetology & Metabolic Syndrome
https://read.qxmd.com/read/38130220/-influence-of-wind-cold-and-dampness-on-clinical-manifestation-of-knee-osteoarthritis-patients-based-on-the-stratifications-of-traditional-chinese-medicine-constitution
#14
JOURNAL ARTICLE
Ze-Cheng Tan, Ding Jiang, Qin-Guang Xu, Lin Wang, Xue-Zong Wang, Bo Chen, Jian Pang, Hong-Sheng Zhan, Yue-Long Cao
OBJECTIVE: To explore influence of external factors of wind, cold and dampness on clinical symptoms in knee osteoarthritis (KOA) patients with different constitutions of traditional Chinese medicine. METHODS: A cross-sectional stratified study was performed to select 108 patients with GradeⅡKOA in Kellgren & Lawrence (K-L) classification, including 22 males and 86 females, aged from 47 to 75 years old with an average of (60.7±6.0) years old;body mass index(BMI) ranged from 17...
December 25, 2023: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://read.qxmd.com/read/38102584/integrated-bioinformatics-and-network-pharmacology-to-explore-the-therapeutic-target-and-molecular-mechanisms-of-bailing-capsule-on-polycystic-ovary-syndrome
#15
JOURNAL ARTICLE
Hao-Ru Guan, Bo Li, Ze-Hua Zhang, Han-Song Wu, Xing-Lishang He, Ying-Jie Dong, Jie Su, Gui-Yuan Lv, Su-Hong Chen
BACKGROUND: Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder that is common in women of reproductive age. The clinical features of PCOS include hyperandrogenemia and polycystic ovarian changes. Bailing capsule (BL), a proprietary Chinese medicine that contains fermented Cordyceps sinensis powder, has been applied to treat PCOS. However, the specific active ingredients of BL and its mechanisms of action are yet to be elucidated. METHODS: Initially, the effectiveness of BL on PCOS model mice was evaluated...
December 15, 2023: BMC complementary medicine and therapies
https://read.qxmd.com/read/38077483/microarray-expression-profile-of-exosomal-circrnas-from-high-glucose-stimulated-human-renal-tubular-epithelial-cells
#16
JOURNAL ARTICLE
Yan-Hua Sha, Song-Ling Cao, Lu Zhang, Li-Sha Lai, Pei-Feng Ke, Ke-Wei Yu, Xiu-Zhu Fang, Ren-Tang Deng, Ze-Min Wan, Xiao-Bin Wu, Guang Han, Yu-Bang Jie, Lan-Lan Song, Xian-Zhang Huang, Wen-Jin Fu
INTRODUCTION: Circular RNA (circRNAs) are a type of non-coding RNA (ncRNAs) with a wealth of functions. Recently, circRNAs have been identified as important regulators of diabetic kidney disease (DKD), owing to their stability and enrichment in exosomes. However, the role of circRNAs in exosomes of tubular epithelial cells in DKD development has not been fully elucidated. METHODS: In our study, microarray technology was used to analyze circRNA expression in cell supernatant exosomes isolated from HK-2 cells with or without high glucose (HG) treatment...
2023: Diabetes, Metabolic Syndrome and Obesity
https://read.qxmd.com/read/38062566/establishment-of-a-taqman-probe-based-qpcr-assay-for-detecting-microsporidia-enterospora-epinepheli-in-grouper
#17
JOURNAL ARTICLE
Quan-Lin Liu, Yuan Wang, Jie Chen, Guo-Qing Pan, Yan-Feng Yue, Ze-Yang Zhou, Wen-Hong Fang
Enterospora epinepheli is an intranuclear microsporidian parasite causing serious emaciative disease in hatchery-bred juvenile groupers (Epinephelus spp.). Rapid and sensitive detection is urgently needed as its chronic infection tends to cause emaciation as well as white faeces syndrome and results in fry mortality. This study established a TaqMan probe-based real-time quantitative PCR assays targeting the small subunit rRNA (SSU) gene of E. epinepheli. The relationship between the standard curve of cycle threshold (Ct) and the logarithmic starting quantity (SQ) was determined as Ct = -3...
December 7, 2023: Journal of Fish Diseases
https://read.qxmd.com/read/38048647/hantaan-virus-inhibits-type-i-interferon-response-by-targeting-rlr-signaling-pathways-through-trim25
#18
JOURNAL ARTICLE
Yinghua Zhao, Lihe Che, Mingming Pan, Yuan Huang, Shu Fang, Mengmeng Wang, Liyan Sui, Ze-Dong Wang, Fang Du, Zhijun Hou, Quan Liu
Hantaan virus (HTNV) is responsible for hemorrhagic fever with renal syndrome (HFRS), primarily due to its ability to inhibit host innate immune responses, such as type I interferon (IFN-I). In this study, we conducted a transcriptome analysis to identify host factors regulated by HTNV nucleocapsid protein (NP) and glycoprotein. Our findings demonstrate that NP and Gc proteins inhibit host IFN-I production by manipulating the retinoic acid-induced gene I (RIG-I)-like receptor (RLR) pathways. Further analysis reveals that HTNV NP and Gc proteins target upstream molecules of MAVS, such as RIG-I and MDA-5, with Gc exhibiting stronger inhibition of IFN-I responses than NP...
January 2024: Virology
https://read.qxmd.com/read/38032112/fluorescence-quenching-lateral-flow-immunoassay-for-turn-on-and-sensitive-detection-of-anti-sars-cov-2-neutralizing-antibodies-in-human-serum
#19
JOURNAL ARTICLE
Lun Bian, Qiangqiang Fu, Zhuoheng Gan, Ze Wu, Yuchen Song, Yufeng Xiong, Fang Hu, Lei Zheng
The titer of anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) neutralizing antibodies (NAbs) in the human body is an essential reference for evaluating the acquired protective immunity and resistance to SARS-CoV-2 infection. In this study, a fluorescence-quenching lateral flow immunoassay (FQ-LFIA) is established for quantitative detection of anti-SARS-CoV-2 NAbs in the sera of individuals who are vaccinated or infected within 10 min. The ultrabright aggregation-induced emission properties encapsulated in nanoparticles, AIE490 NP, are applied in the established FQ-LFIA with gold nanoparticles to achieve a fluorescence "turn-on" competitive immunoassay...
November 30, 2023: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/37991568/identifying-the-interaction-between-tuberculosis-and-sars-cov-2-infections-via-bioinformatics-analysis-and-machine-learning
#20
JOURNAL ARTICLE
Ze-Min Huang, Jia-Qi Kang, Pei-Zhen Chen, Lin-Fen Deng, Jia-Xin Li, Ying-Xin He, Jie Liang, Nan Huang, Tian-Ye Luo, Qi-Wen Lan, Hao-Kai Chen, Xu-Guang Guo
The number of patients with COVID-19 caused by severe acute respiratory syndrome coronavirus 2 is still increasing. In the case of COVID-19 and tuberculosis (TB), the presence of one disease affects the infectious status of the other. Meanwhile, coinfection may result in complications that make treatment more difficult. However, the molecular mechanisms underpinning the interaction between TB and COVID-19 are unclear. Accordingly, transcriptome analysis was used to detect the shared pathways and molecular biomarkers in TB and COVID-19, allowing us to determine the complex relationship between COVID-19 and TB...
November 22, 2023: Biochemical Genetics
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