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https://www.readbyqxmd.com/read/29338055/a-novel-gerstmann-str%C3%A3-ussler-scheinker-disease-mutation-defines-a-precursor-for-amyloidogenic-8-kda-prp-fragments-and-reveals-n-terminal-structural-changes-shared-by-other-gss-alleles
#1
Robert C C Mercer, Nathalie Daude, Lyudmyla Dorosh, Ze-Lin Fu, Charles E Mays, Hristina Gapeshina, Serene L Wohlgemuth, Claudia Y Acevedo-Morantes, Jing Yang, Neil R Cashman, Michael B Coulthart, Dawn M Pearson, Jeffrey T Joseph, Holger Wille, Jiri G Safar, Gerard H Jansen, Maria Stepanova, Brian D Sykes, David Westaway
To explore pathogenesis in a young Gerstmann-Sträussler-Scheinker Disease (GSS) patient, the corresponding mutation, an eight-residue duplication in the hydrophobic region (HR), was inserted into the wild type mouse PrP gene. Transgenic (Tg) mouse lines expressing this mutation (Tg.HRdup) developed spontaneous neurologic syndromes and brain extracts hastened disease in low-expressor Tg.HRdup mice, suggesting de novo formation of prions. While Tg.HRdup mice exhibited spongiform change, PrP aggregates and the anticipated GSS hallmark of a proteinase K (PK)-resistant 8 kDa fragment deriving from the center of PrP, the LGGLGGYV insertion also imparted alterations in PrP's unstructured N-terminus, resulting in a 16 kDa species following thermolysin exposure...
January 16, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29320646/transfer-of-fresh-versus-frozen-embryos-in-ovulatory-women
#2
Yuhua Shi, Yun Sun, Cuifang Hao, Heping Zhang, Daimin Wei, Yunshan Zhang, Yimin Zhu, Xiaohui Deng, Xiujuan Qi, Hong Li, Xiang Ma, Haiqin Ren, Yaqin Wang, Dan Zhang, Bo Wang, Fenghua Liu, Qiongfang Wu, Ze Wang, Haiyan Bai, Yuan Li, Yi Zhou, Mei Sun, Hong Liu, Jing Li, Lin Zhang, Xiaoli Chen, Songying Zhang, Xiaoxi Sun, Richard S Legro, Zi-Jiang Chen
BACKGROUND: Elective frozen-embryo transfer has been shown to result in a higher live-birth rate than fresh-embryo transfer among anovulatory women with the polycystic ovary syndrome. It is uncertain whether frozen-embryo transfer increases live-birth rates among ovulatory women with infertility. METHODS: In this multicenter, randomized trial, we randomly assigned 2157 women who were undergoing their first in vitro fertilization cycle to undergo either fresh-embryo transfer or embryo cryopreservation followed by frozen-embryo transfer...
January 11, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29306151/enhancement-of-immune-response-of-piglets-to-pcv-2-vaccine-by-porcine-il-2-and-fusion-il-4-6-gene-entrapped-in-chitosan-nanoparticles
#3
Yi Chen, Tingyu Song, Yong-Le Xiao, Xiaoping Wan, Luyi Yang, Jinghai Li, Guangzhi Zeng, Pengfei Fang, Ze-Zhou Wang, Rong Gao
In order to develop a novel effective immunomodulator to enhance pig resistance against post-weaning multi systemic wasting syndrome (PMWS), a recombinant plasmid co-expressing pig interleukin-2 (IL-2) and fusion interleukin-4/6 (IL-4/6) genes, designated VRIL4/6-2, was constructed and encapsulated in chitosan (CS) nanoparticles prepared by the ionotropic gelation method. Then 21-day old piglets were divided into two groups and intramuscularly injected respectively with VPIL4/6-2-CS and saline along with the porcine circovirus-2 (PCV-2) vaccine...
December 29, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/29219920/the-fatty-liver-index-a-simple-and-accurate-predictor-of-colorectal-adenoma-in-an-average-risk-population
#4
Eun Young Ze, Beom Jin Kim, Dong Hwan Jun, Jae Gyu Kim, Hyun Kang, Dong Young Lee
BACKGROUND: Nonalcoholic fatty liver disease, the hepatic manifestation of metabolic syndrome, is associated with increased risk of colorectal adenoma, a precursor of colorectal cancer. Because nonalcoholic fatty liver disease and colorectal adenoma share many common risk factors of metabolic syndrome, the association between these 2 pathological findings has been investigated in multiple studies, but the results have been conflicting. OBJECTIVE: The present study aimed to assess the relationship between the fatty liver index, a predictor of nonalcoholic fatty liver disease, and the prevalence of colorectal adenomas...
January 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29212183/role-of-il-17-in-lps-induced-acute-lung-injury-an-in-vivo-study
#5
Qi Ding, Gao-Qin Liu, Yuan-Yuan Zeng, Jian-Jie Zhu, Ze-Yi Liu, Xueguang Zhang, Jian-An Huang
To assess the clinical significance of IL-17 in patients with sepsis-induced acute respiratory distress syndrome (ARDS) and to investigate the effects of IL-17 blocking in a mouse model of acute lung injury (ALI). Significantly increased IL-17 level was found in patients with sepsis-related ARDS compared to healthy controls, whereas significantly increased plasma IL-17 level was also observed in non-survivors compared to that in survivors. According to the data from the mouse ALI model, we found significantly increased IL-17 level in lung tissue lysates, mouse bronchoalveolar lavage fluid (mBALF) and plasma at 6, 12 and 24 h after ALI...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29203746/-effectiveness-of-early-physiotherapy-treatment-for-ischaemic-stroke-patients-suffering-intercurrently-from-post-stroke-depression-and-or-hemispatial-neglect-syndromes
#6
Justyna Ćwieląg, Marta Woldańska-Okońska
Wstęp: Depresja poudarowa i zespoł pomijania stronnego są jednymi z szeregu zaburzeń neurologicznych występujących jako konsekwencje incydentu udarowego. Oba zaburzenia uważa się za czynniki negatywnie wpływające na szybszy powrot pacjenta do zdrowia. Zadaniem wczesnej fizjoterapii po incydencie udarowym jest poprawa funkcji motorycznych oraz poprawa jakości życia pacjenta. Materiał i metody: W badaniu wzięło udział 51 pacjentow zakwalifikowanych do wzięcia udziału w "Narodowym Programie Profilaktyki i Leczenia Chorob Układu Sercowo-Naczyniowego na lata 2006-2008 POLCARD"...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29179484/association-of-circulating-branched-chain-amino-acids-with-cardiometabolic-traits-differs-between-adults-and-the-oldest-old
#7
Liang Sun, Caiyou Hu, Ruiyue Yang, Yuan Lv, Huiping Yuan, Qinghua Liang, Benjin He, Guofang Pang, Menghua Jiang, Jun Dong, Ze Yang
Branched-chain amino acids (BCAAs) are promising for their potential anti-aging effects. However, findings in adults suggest that circulating BCAAs are associated with cardiometabolic risk. Moreover, little information is available about how BCAAs influence clustered cardiometabolic traits in the oldest-old (>85 years), which are the fastest-growing segment of the population in developed countries. Here, we applied a targeted metabolomics approach to measure serum BCAAs in Chinese participants (aged 21-110 years) based on a longevity cohort...
October 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/29176715/inhalation-exposure-to-pm2-5-counteracts-hepatic-steatosis-in-mice-fed-high-fat-diet-by-stimulating-hepatic-autophagy
#8
Yining Qiu, Ze Zheng, Hyunbae Kim, Zhao Yang, Gary Zhang, Xiangyang Shi, Fei Sun, Changya Peng, Yuchuan Ding, Aixia Wang, Lung-Chi Chen, Sanjay Rajagopalan, Qinghua Sun, Kezhong Zhang
Air pollution is associated with the increased risk of metabolic syndrome. In this study, we performed inhalation exposure of mice fed normal chow or a high-fat diet to airborne fine particulate matters (PM2.5), and then investigated the complex effects and mechanisms of inhalation exposure to PM2.5 on hepatic steatosis, a precursor or manifestation of metabolic syndrome. Our studies demonstrated that inhalation exposure of mice fed normal chow to concentrated ambient PM2.5 repressed hepatic transcriptional regulators involved in fatty acid oxidation and lipolysis, and thus promoted hepatic steatosis...
November 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29171989/comparative-analysis-of-immune-function-hemorheological-alterations-and-prognosis-in-colorectal-cancer-patients-with-different-traditional-chinese-medicine-syndromes
#9
Cheng-Yang Wang, Huan-Zhang Ding, Xiao Tang, Ze-Geng Li
OBJECTIVE: The present study investigates the differences in immune function, hemorheological alterations and prognostic evaluation in colorectal cancer (CRC) patients with different traditional Chinese medicine (TCM) syndromes. METHODS: A total of 128 patients, diagnosed as stage II and III of CRC, were recruited. They were assigned into three TCM syndromes: deficiency syndrome, excess syndrome, and syndrome of intermingled deficiency and excess, and another 53 healthy individuals were selected as the control...
November 17, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29130666/-application-of-chromosomal-microarray-analysis-for-chromosomal-abnormalities-of-spontaneously-aborted-fetuses
#10
Ting Hu, Hong-Mei Zhu, Zhu Zhang, Jia-Min Wang, Hai-Xia Zhang, Ze Du, Ling-Pingi Li, He Wang, Shan-Ling Liu
OBJECTIVE: To evaluate the clinical significance of chromosomal microarry analysis (CMA) for detection of chromosomal abnormalities in spontaneously aborted fetuses. METHODS: Chorionic villi samples from 431 spontaneously aborted fetuses were detected on the chromosomal abnormalities by CMA in our department form September 2014 to April 2016. RESULTS: The overall success rate of CMA was 100%,and 283 cases were detected with abnormalities (65...
September 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/29063076/restless-legs-syndrome-secondary-to-pontine-infarction-clinical-analysis-of-five-cases
#11
Hou-Zhen Tuo, Ze-Long Tian, Yi-Nong Cui, Xiao-Yang Ma, Chun-Ling Xu, Hong-Yan Bi, Li-Yan Zhang, Yong-Bo Zhang, Wei-Dong Le, William Ondo
OBJECTIVE: Pontine infarction is a common type of stroke in the cerebral deep structures, resulting from occlusion of small penetrating arteries, may manifest as hemi-paralysis, hemi-sensory deficit, ataxia, vertigo, and bulbar dysfunction, but patients presenting with restless legs syndrome (RLS) are extremely rare. Herein, we reported five cases with RLS as a major manifestation of pontine infarction. METHODS: Five cases of pontine infarction related RLS were collected from July 2013 to February 2016...
September 2017: Chronic Diseases and Translational Medicine
https://www.readbyqxmd.com/read/29052562/clinical-profile-and-significance-of-mucocutaneous-lesions-of-primary-sj%C3%A3-gren-s-syndrome-a-large-cross-sectional-study-with-874-patients
#12
Lei Xuan, Yi-Dong Zhang, Li Li, Yue-Ping Zeng, Hao-Ze Zhang, Jing Wang, Zhen-Hua Dong
BACKGROUND: Mucocutaneous lesions are common features of primary Sjögren's syndrome (pSS), but only a few studies have focused on them. To demonstrate the profile of mucocutaneous lesions of pSS and further explore their potential clinical significance, we performed a cross-sectional study on 874 patients. METHODS: Demographic data, clinical manifestations, and laboratory results of 874 pSS patients were collected. Patients were divided into two groups according to the presence of mucocutaneous lesions...
October 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28953669/ultrasonic-monitoring-in-the-assessment-of-pulmonary-recruitment-and-the-best-positive-end-expiratory-pressure
#13
RANDOMIZED CONTROLLED TRIAL
Ke-Qiang Tang, Shao-Ling Yang, Bin Zhang, Hong-Xiang Liu, Dong-Ying Ye, Hong-Ze Zhang, Shuang Ma
The aim of this study was to explore the clinical value of ultrasonic monitoring in the assessment of pulmonary recruitment and the best positive end-expiratory pressure (PEEP).Between January 2015 and June 2017, 40 patients with acute respiratory distress syndrome in our hospital were randomly divided into 2 groups: ultrasound group (ULS group; n = 20) and oxygenation group (OXY group; n = 20). The PEEP incremental method was used to perform recruitment maneuvers. Ultrasound scoring and the oxygenation method were used to evaluate the pulmonary recruitment endpoint...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28851958/predictive-value-of-serum-gamma-glutamyltranspeptidase-for-future-cardiometabolic-dysregulation-in-adolescents-a-10-year-longitudinal-study
#14
Chien-Ming Lin, Chang-Hsun Hsieh, Chien-Hsing Lee, Dee Pei, Jiunn-Diann Lin, Chung-Ze Wu, Yao-Jen Liang, Yi-Jen Hung, Yen-Lin Chen
Serum gamma-glutamyltransferase (γ-GT) is implicated in the pathogenesis of atherosclerosis and metabolic syndrome (MetS) in adults. The relationships between γ-GT and cardiometabolic dysregulation remains unclear in adolescents. We enrolled 7,072 Taiwanese adolescents and followed them for a median of 6.8 years. The optimal cut-off values (CoVs) of baseline γ-GT to predict future MetS, hypertension (HTN), and type 2 diabetes (T2DM) were determined by receiving operating characteristic (ROC) curve. Using these CoVs, the participants were divided into normal- and high-level groups...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28809820/certain-dietary-habits-contribute-to-the-functional-dyspepsia-in-south-china-rural-area
#15
Ji-Hao Xu, Yu Lai, Li-Ping Zhuang, Can-Ze Huang, Chu-Qiang Li, Qi-Kui Chen, Tao Yu
BACKGROUND Functional dyspepsia (FD) refers to a group of upper gastrointestinal syndromes, subdivided into two types: postprandial distress syndrome (PDS) and epigastric pain syndrome (EPS). The etiology of FD remains unclear; however, unhealthy dietary habit is one potential underlying cause. We aim to explore the association of poor dietary habits with FD and its subtypes. MATERIAL AND METHODS A validated epidemiological questionnaire was designed to investigate dietary habits and gastrointestinal syndromes...
August 15, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28804682/effects-of-intensive-pitavastatin-therapy-on-glucose-control-in-patients-with-non-st-elevation-acute-coronary-syndrome
#16
Yan-Bo Wang, Xiang-Hua Fu, Xin-Shun Gu, Wei-Ze Fan, Yun-Fa Jiang, Guo-Zhen Hao, Qing Miao, Jie Cao, Bing Fu, Yi Li
Objective: This study aimed to investigate the effects of intensive pitavastatin therapy on glucose control in patients with non-ST elevation acute coronary syndrome (ACS). Methods: Patients who had ACS with significant stenosis on initial coronary angiography and received successful percutaneous coronary intervention (PCI) in the Second Hospital of Hebei Medical University, Shijiazhuang, China from August 2015 to January 2016 were enrolled in this study. The patients were randomized to receive pitavastatin (4 mg daily) or atorvastatin (20 mg daily)...
2017: American Journal of Cardiovascular Disease
https://www.readbyqxmd.com/read/28760137/prevalence-and-clinical-profile-of-metabolic-syndrome-in-longevity-study-from-guangxi-zhuang-autonomous-region-china
#17
Xianghua He, Wei Zhang, Guofang Pang, Yuan Lv, Caiyou Hu, Ze Yang
BACKGROUND: Metabolic syndrome (MetS) was a risk factor for cardiovascular diseases, yet the prevalence of MetS among nonagenarians and centenarians was rarely reported. Here we investigated the prevalence of MetS and its components among nonagenarians and centenarians in our Zhuang population from Bama, Guangxi Zhuang Autonomous Region, China. METHOD: In Bama area, there registered 881 individuals who lived more than 90 years old in 269,800 local residents and our study involved 307 long-lived participants and 486 local younger (35-68 years) persons, as controls...
July 31, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28691030/a-novel-capillary-electrophoresis-based-high-throughput-multiplex-polymerase-chain-reaction-system-for-the-simultaneous-detection-of-nine-pathogens-in-swine
#18
Xu-Long Wu, Lu Xiao, Hua Lin, Miao Yang, Shi-Jie Chen, Wei An, Yin Wang, Xue-Ping Yao, Ze-Xiao Yang, Zi-Zhong Tang
Here we aimed to develop a capillary electrophoresis-based high-throughput multiplex polymerase chain reaction (PCR) system for the simultaneous detection of nine pathogens in swine. Nine pairs of specific primers and a set of universal primers were designed; the multiplex PCR was established. The specificity and cross-reactivity of this assay were examined, and the detection limit was determined using serial 10-fold dilutions of plasmids containing the target sequences. The assay was further tested using 144 clinical samples...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28663379/in-obese-mice-exercise-training-increases-11%C3%AE-hsd1-expression-contributing-to-glucocorticoid-activation-and-suppression-of-pulmonary-inflammation
#19
Shu-Fang Du, Qing Yu, Kai Chuan, Chang-Lin Ye, Ze-Jia He, Shu-Juan Liu, Xiao-Yan Zhu, Yu-Jian Liu
Exercise training is advocated for treating chronic inflammation and obesity-related metabolic syndromes. Glucocorticoids (GCs), the anti-inflammatory hormones, are synthesized or metabolized in extra-adrenal organs. This study aims to examine whether exercise training affects obesity-associated pulmonary inflammation by regulating local GCs synthesis or metabolism. We found that the sedentary obese (ob/ob) mice exhibited increased levels of interleukin (IL)-1β, IL-18, monocyte chemotactic protein (MCP)-1, and leukocyte infiltration in lung tissues compared with the lean mice, which was alleviated by 6 weeks of exercise training...
June 29, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28640118/high-normotension-is-associated-with-future-metabolic-syndrome-but-not-cardiovascular-disease-a-10-year-longitudinal-study
#20
Yen-Lin Chen, Chun-Hsien Hsu, Chang-Hsun Hsieh, Chung-Ze Wu, Jiunn-Diann Lin, Jin-Biou Chang, Yao-Jen Liang, Yi-Ting Tsai, Te-Lin Hsia, Dee Pei
Hypertension and prehypertension can increase the risk of developing cardiovascular disease (CVD) and diabetes. However, whether the harmful effects of high blood pressure (BP) are also seen with high normotension remains unknown. This 10-year longitudinal follow-up study aimed to investigate the relationships among normal-range BP, metabolic syndrome (MetS), and CVD.A total of 9133 nonmedicated normotensive participants, 4634 males and 4499 females, aged 60 years or older were enrolled in a standard health examination program at 2 academic hospitals and a health screening center in Taiwan...
June 2017: Medicine (Baltimore)
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