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https://www.readbyqxmd.com/read/27865197/efficacy-and-safety-of-ticagrelor-versus-clopidogrel-with-different-dosage-in-high-risk-patients-with-acute-coronary-syndrome
#1
Yan-Guo Xin, Hai-Shan Zhang, Yu-Ze Li, Qi-Gang Guan, Liang Guo, Yuan Gao, Hai-Jie Yu, Xin-Gang Zhang, Feng Xu, Yue-Lan Zhang, Da-Lin Jia, Ying-Xian Sun, Guo-Xian Qi, Wen Tian
BACKGROUND: Dual antiplatelet therapy is recommended as a standard antiplatelet strategy in acute coronary syndrome. For those with reduced pharmacologic response to clopidogrel, strengthening antiplatelet therapy (clopidogrel 150mg daily) may reduce adverse clinical events. Ticagrelor is a direct-acting inhibitor of the adenosine diphosphate receptor P2Y12 that has a more rapid onset and offset than clopidogrel. METHODS: In this retrospective study, we compared ticagrelor (180mg loading dose 90mg twice daily thereafter), clopidogrel (300mg loading dose, 75mg or 150mg daily thereafter) for the prevention of cardiovascular events in 273 high-risk patients admitted to coronary care unit with acute coronary syndrome...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27779167/a-missense-mutation-in-epsilon-subunit-of-acetylcholine-receptor-causing-autosomal-dominant-slow-channel-congenital-myasthenic-syndrome-in-a-chinese-family
#2
Jia-Ze Tan, Yuan Man, Fei Xiao
BACKGROUND: Congenital myasthenic syndromes are a group of rare disorders that are clinically and genetically heterogeneous and caused by mutations in the genes encoding proteins of the neuromuscular junction. Here, we described a Chinese family that presented with phenotypes of classic slow-channel congenital myasthenic syndrome (SCCMS). METHODS: Clinical characteristics and electrophysiological features of three patients from a Chinese family were examined, and next-generation sequencing followed by direct sequencing was carried out...
2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27614452/non-invasive-treatment-to-grade-1-essential-hypertension-by-percutaneous-laser-and-electric-pulse-to-acupoint-with-music-a-randomized-controlled-trial
#3
Hong-Rui Zhan, Zhong-Si Hong, Yi-Shen Chen, Hai-Yu Hong, Ze-Bin Weng, Zhang-Bin Yang, Jing-Li Shi, Zhong-Ben Chen
OBJECTIVE: To study a non-drug therapy for hypertension disease by combining percutaneous laser and electric pulse stimulation to acupoint with music, and to test the efficiency of the combining treatment to grade 1 essential hypertension. METHODS: A total of 174 patients with grade 1 essential hypertension were randomly assigned to 3 groups with a random number table after Chinese medicine (CM) syndrome differentiation: the photoelectric and musical treatment group (Group 1, with a self-developed multi-mode audio frequency pulse photoelectric therapeutic apparatus), acupuncture group (Group 2), and oral placebo group (Group 3), 58 cases per group...
September 2016: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/27578536/association-of-adiponectin-polymorphism-with-metabolic-syndrome-risk-and-adiponectin-level-with-stroke-risk-a-meta-analysis
#4
Hui-Ping Yuan, Liang Sun, Xing-Hui Li, Fu-Gang Che, Xiao-Quan Zhu, Fan Yang, Jing Han, Chun-Yuan Jia, Ze Yang
Many previous studies have provided evidence that the ADIPOQ +45T>G polymorphism (rs2241766) might cause metabolic syndrome (MS). As a cardiovascular manifestation of MS, the incidence of stroke is associated with adiponectin; however, the results remain controversial and inconsistent. Systematic searches of relevant studies published up to Dec 2014 and Jan 2016 on the ADIPOQ +45T>G polymorphism and the risk of MS and adiponectin levels and the risk of stroke, respectively, were conducted in MEDLINE and EMBASE...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27491235/-effects-of-jianpi-jiedu-recipe-on-tcrv%C3%AE-cdr3-spectratyping-of-liver-cancer-rats-with-pi-deficiency-syndrome
#5
Bao-guo Sun, Lei Zhang, Ting Xiang, Ze-xiong Chen, Shi-jun Zhang
OBJECTIVE: To observe anti-cancer effects of Jianpi Jiedu Recipe (JJR) on liver cancer (LC) rats with Pi deficiency syndrome (PDS) and its relation with the third complementary-determining region gene spectratyping of TCRVβ-chain (TCRVβCDR3). METHODS: Rats were divided into 8 groups according to random digit table, i.e., the blank control group (normal), the PDS group, the LC model group, the LC-PDS group, high, middle, and low dose JJR groups (75.00, 37.50, 18...
June 2016: Chinese Journal of Integrated Traditional and Western Medicine
https://www.readbyqxmd.com/read/27303892/identification-of-impaired-second-phase-insulin-secretion-in-various-degrees-of-glucose-tolerance-in-a-chinese-population
#6
Jiunn-Diann Lin, Chung-Ze Wu, Dee Pei, Wei-Cheng Lian, Chun-Hsien Hsu, Chang-Hsun Hsieh, Yen-Lin Chen
AIM: Impaired insulin sensitivity and insulin secretion (ISEC) are major pathophysiologies of type 2 diabetes (T2DM). ISEC has two phases: the first and second phases (second ISEC). In this study, we derived equations to identify patients with second ISEC deficiency (ISEC-D). METHODS: Data from 96 patients, namely 19 with a normal fasting plasma glucose (FPG) level, 21 with prediabetes, and 56 with T2DM, were enrolled. They underwent a modified low-dose graded glucose infusion test, which was originally proposed by Polonsky et al...
September 2016: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/27231180/successful-renal-transplantation-in-a-patient-with-atypical-hemolytic-uremic-syndrome-treated-with-eculizumab-in-china
#7
Ze-Jia Sun, Xin Du, Lu-Lu Su, Xiao-Dong Zhang, Yong Wang, Liang Ren, Wei Wang
No abstract text is available yet for this article.
June 5, 2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27158117/a-novel-substituted-aminoquinoline-selectively-targets-voltage-sensitive-sodium-channel-isoforms-and-nmda-receptor-subtypes-and-alleviates-chronic-inflammatory-and-neuropathic-pain
#8
Boris Tabakoff, Wenhua Ren, Lauren Vanderlinden, Lawrence D Snell, Christopher J Matheson, Ze-Jun Wang, Rock Levinson, C Thetford Smothers, John J Woodward, Yumiko Honse, David Lovinger, Anthony M Rush, William A Sather, Daniel L Gustafson, Paula L Hoffman
Recent understanding of the systems that mediate complex disease states, has generated a search for molecules that simultaneously modulate more than one component of a pathologic pathway. Chronic pain syndromes are etiologically connected to functional changes (sensitization) in both peripheral sensory neurons and in the central nervous system (CNS). These functional changes involve modifications of a significant number of components of signal generating, signal transducing and signal propagating pathways. Our analysis of disease-related changes which take place in sensory neurons during sensitization led to the design of a molecule that would simultaneously inhibit peripheral NMDA receptors and voltage sensitive sodium channels...
August 5, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27077763/prognostic-significance-of-asxl1-mutations-in-myelodysplastic-syndromes-and-chronic-myelomonocytic-leukemia-a-meta-analysis
#9
Yun Lin, Yi Zheng, Ze-Chuan Wang, Shao-Yuan Wang
OBJECTIVES: Although additional sex comb-like 1 (ASXL1) gene mutations have long been reported in myelodysplastic syndromes (MDSs) and chronic myelomonocytic leukemia (CMML), the prognostic significance has been controversial. Therefore, a meta-analysis to study the impact of ASXL1 mutations on patients with MDS and CMML is useful. METHODS: The identified articles were retrieved from some common databases. We extracted hazard ratios (HRs) for overall survival (OS) and leukemic-free survival (LFS) and P-value of some clinical parameters, which compared AXSL1 mutations to those without from the available studies...
September 2016: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/27057846/identification-of-normal-blood-pressure-in-different-age-group
#10
Jiunn-Diann Lin, Yen-Lin Chen, Chung-Ze Wu, Chang-Hsun Hsieh, Dee Pei, Yao-Jen Liang, Jin-Biou Chang
The concept of using single criterion of normal blood pressure with systolic blood pressure (SBP) < 140 mmHg and diastolic blood pressure (DBP) < 90 mmHg for all ages is still disputable. The aim of the study is to identify the cutoff value of normotension in different age and sex groups.Totally, 127,922 (63,724 men and 64,198 women) were enrolled for the analysis. Finally, four fifths of them were randomly selected as the study group and the other one fifths as the validation group. Due the tight relationship with comorbidities from cardiovascular disease (CVD), metabolic syndrome (MetS) was used as a surrogate to replace the actual cardiovascular outcomes in the younger subjects...
April 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26833708/dihydro-resveratrol-ameliorates-lung-injury-in-rats-with-cerulein-induced-acute-pancreatitis
#11
Ze-Si Lin, Chuen Fai Ku, Yi-Fu Guan, Hai-Tao Xiao, Xiao-Ke Shi, Hong-Qi Wang, Zhao-Xiang Bian, Siu Wai Tsang, Hong-Jie Zhang
Acute pancreatitis is an inflammatory process originated in the pancreas; however, it often leads to systemic complications that affect distant organs. Acute respiratory distress syndrome is indeed the predominant cause of death in patients with severe acute pancreatitis. In this study, we aimed to delineate the ameliorative effect of dihydro-resveratrol, a prominent analog of trans-resveratrol, against acute pancreatitis-associated lung injury and the underlying molecular actions. Acute pancreatitis was induced in rats with repetitive injections of cerulein (50 µg/kg/h) and a shot of lipopolysaccharide (7...
April 2016: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/26806164/down-regulation-apoptosis-signal-regulating-kinase-1-gene-reduced-the-litopenaeus-vannamei-hemocyte-apoptosis-in-wssv-infection
#12
Feng-Hua Yuan, Yong-Gui Chen, Ze-Zhi Zhang, Hai-Tao Yue, Hai-Tao Bi, Kai Yuan, Shao-Ping Weng, Jian-Guo He, Yi-Hong Chen
Apoptosis signal-regulating kinase 1 (ASK1), a mitogen-activated protein kinase kinase kinase, is crucial in various cellular responses. In the present study, we identified and characterized an ASK1 homolog from Litopenaeus vannamei (LvASK1). The full-length cDNA of LvASK1 was 5400 bp long, with an open reading frame encoding a putative 1420 amino acid protein. LvASK1 was highly expressed in muscle, hemocyte, eyestalk and heart. Real-time RT-PCR analysis showed that the expression of the LvASK1 was upregulated during the white spot syndrome virus (WSSV) challenge...
March 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/26691577/identification-and-functional-characterization-of-a-solute-carrier-family-15-member-4-gene-in-litopenaeus-vannamei
#13
Yong-Gui Chen, Kai Yuan, Ze-Zhi Zhang, Feng-Hua Yuan, Shao-Ping Weng, Hai-Tao Yue, Jian-Guo He, Yi-Hong Chen
Innate immunity in shrimp is important in resisting bacterial infection. The NF-κB pathway is pivotal in such an immune response. This study cloned and functionally characterized the solute carrier family (SLC) 15 member A 4 (LvSLC15A4) gene in Litopenaeus vannamei. The open reading frame of LvSLC15A4 is 1, 902 bp long and encodes a putative 633-amino acid protein, which is localized in the plasma membrane and intracellular vesicular compartments. Results of the reporter gene assay showed that LvSLC15A4 upregulated NF-κB target genes, including the immediate-early gene 1 of white spot syndrome virus, as well as several antimicrobial peptide genes, such as pen4, CecA, AttA, and Mtk in S2 cells...
April 2016: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/26677680/-exploring-the-correlation-between-pi-and-shen-from-the-excretion-of-aa-i-and-expressions-of-or-ganic-anion-transporting-polypeptide-2al-and-2-b1-in-pi-deficiency-model-rats
#14
Ting Xiang, Bin Ren, Zhang-bin Yang, Bao-guo Sun, Ze-xiong Chen, Yan Chen, Shi-jun Zhang
OBJECTIVE: To explore the correlation between Pi and Shen by observing the relationship between the metabolism of aristolochic acid (AA) and mRNA and protein expression levels of organic anion transporting polypeptide (oatp) superfamily member 2a1 and 2 b1 (oatp2al and oatp2bl) in renal, small intestinal, and large intestinal tissues of Pi deficiency syndrome (PDS) model rats. METHODS: Totally 46 Sprague-Dawley (SD) rats were randomly divided into four groups, i...
October 2015: Chinese Journal of Integrated Traditional and Western Medicine
https://www.readbyqxmd.com/read/26633970/association-among-fibrinolytic-proteins-metabolic-syndrome-components-insulin-secretion-and-resistance-in-schoolchildren
#15
Jin-Shuen Chen, Chung-Ze Wu, Nain-Feng Chu, Li-Chien Chang, Dee Pei, Yuh-Feng Lin
We investigated the role of urokinase plasminogen activator (uPA) and its soluble receptors (suPAR) and plasminogen activator inhibitor-1 (PAI-1) in metabolic syndrome (MetS) components, insulin secretion, and resistance in schoolchildren. We enrolled 387 children, aged 10.3 ± 1.5 years, in Taipei. Anthropometry, fibrinolytic proteins, MetS components, insulin secretion, and resistance were measured. Subjects were divided into normal, overweight, and obese groups. Finally, the relationship between fibrinolytic proteins and metabolic syndrome in boys and girls was analyzed...
2015: International Journal of Endocrinology
https://www.readbyqxmd.com/read/26631649/identification-and-functional-characterization-of-an-endoplasmic-reticulum-oxidoreductin-1-%C3%AE-gene-in-litopenaeus-vannamei
#16
Ze-Zhi Zhang, Kai Yuan, Hai-Tao Yue, Feng-Hua Yuan, Hai-Tao Bi, Shao-Ping Weng, Jian-Guo He, Yi-Hong Chen
In the current study, full-length sequence of endoplasmic reticulum oxidoreductin 1-α (LvERO1-α) was cloned from Litopenaeus vannamei. Real-time RT-PCR results showed that LvERO1-α was highly expressed in hemocytes, gills, and intestines. White spot syndrome virus (WSSV) challenge was performed, and the expression of LvERO1-α and two other downstream genes of the double-stranded RNA-activated protein kinase-like ER kinase-eIF2α (PERK-α) pathway, namely, homocysteine-induced endoplasmic reticulum protein (LvHERP) and acylamino-acid-releasing enzyme (LvAARE), strongly increased in the hemocytes...
April 2016: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/26608988/renal-doppler-and-novel-biomarkers-to-assess-acute-kidney-injury-in-a-swine-model-of-ventricular-fibrillation-cardiac-arrest
#17
Xue Mei, Chen-Chen Hang, Shuo Wang, Chun-Sheng Li, Ze-Xing Yu
BACKGROUND: Majority of the research on cardiac arrest (CA) have focused on post-CA brain injury and myocardial dysfunction, the renal dysfunction and acute kidney injury (AKI) in other critical illnesses after CA have not been well described. This study was designed to assess AKI with renal Doppler and novel AKI biomarkers in a swine model of ventricular fibrillation cardiac arrest (VFCA). METHODS: Thirty healthy piglets were divided into VFCA group (n = 22) and Sham group (n = 8) in a blinded manner...
November 20, 2015: Chinese Medical Journal
https://www.readbyqxmd.com/read/26594174/nlrp3-inflammasome-and-its-inhibitors-a-review
#18
REVIEW
Bo-Zong Shao, Zhe-Qi Xu, Bin-Ze Han, Ding-Feng Su, Chong Liu
Inflammasomes are newly recognized, vital players in innate immunity. The best characterized is the NLRP3 inflammasome, so-called because the NLRP3 protein in the complex belongs to the family of nucleotide-binding and oligomerization domain-like receptors (NLRs) and is also known as "pyrin domain-containing protein 3". The NLRP3 inflammasome is associated with onset and progression of various diseases, including metabolic disorders, multiple sclerosis, inflammatory bowel disease, cryopyrin-associated periodic fever syndrome, as well as other auto-immune and auto-inflammatory diseases...
2015: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/26576838/normal-fasting-plasma-glucose-predicts-type-2-diabetes-and-cardiovascular-disease-in-elderly-population-in-taiwan
#19
C-L Huang, H-W Chang, J-B Chang, J-H Chen, J-D Lin, C-Z Wu, D Pei, Y-J Hung, C-H Lee, Y-L Chen, C-H Hsieh
BACKGROUND: Hyperglycemia increases prevalence of metabolic syndrome (MetS), type 2 diabetes (T2D) and cardiovascular disease (CVD). But the role of normoglycemia on the development of T2D and CVD in elderly population remains unclear. AIM: To determine an optimal cut-off for fasting plasma glucose (FPG) to predict MetS and subsequent risk of T2D and CVD in an elderly Taiwanese population with normal FPG levels. DESIGN: Two stages included cross-sectional (Stage 1) and prospective (Stage 2) cohort study...
August 2016: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/26308292/serum-uric-acid-levels-and-risk-of-metabolic-syndrome-a-dose-response-meta-analysis-of-prospective-studies
#20
REVIEW
Huiping Yuan, Chenglong Yu, Xinghui Li, Liang Sun, Xiaoquan Zhu, Chengxiao Zhao, Zheng Zhang, Ze Yang
CONTEXT: An excess circulating uric acid level, even within the normal range, is always comorbid with metabolic syndrome (MS), several of its components, and nonalcoholic fatty liver disease (NAFLD), which was regarded as hepatic manifestation of MS; however, these associations remain controversial. OBJECTIVE: This study aimed to quantitatively assess the relationship between the serum uric acid (SUA) levels and the MS/NAFLD risk. DESIGN: We searched for related prospective cohort studies including SUA as an exposure and MS/NAFLD as a result in MEDLINE (PubMed) and EMBASE databases up to January 31, 2015 and July 28, 2015, respectively...
November 2015: Journal of Clinical Endocrinology and Metabolism
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