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https://www.readbyqxmd.com/read/29221958/a-comparison-of-the-ultrathin-orsiro-hybrid-sirolimus-eluting-stent-with-contemporary-drug-eluting-stents-a-meta-analysis-of-randomized-controlled-trials
#1
Michael J Lipinski, Brian J Forrestal, Micaela Iantorno, Rebecca Torguson, Ron Waksman
BACKGROUND: Recent studies suggest the Orsiro sirolimus-eluting stent (O-SES), which has ultrathin struts with a biodegradable sirolimus-eluting polymer coating, performed better than contemporary drug-eluting stents (DES). We performed a meta-analysis to compare clinical outcomes for all randomized controlled trials (RCTs) of O-SES vs contemporary DES. METHODS/MATERIALS: PubMed, Cochrane CENTRAL, and meeting abstracts were searched for all RCTs comparing O-SES with contemporary DES...
November 21, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29206128/conformational-study-of-z-5-4-chlorobenzylidene-2-4-2-hydroxyethyl-piperazin-1-yl-3h-imidazol-4-5h-one-in-different-environments-insight-into-the-structural-properties-of-bacterial-efflux-pump-inhibitors
#2
Ewa Żesławska, Wojciech Nitek, Jadwiga Handzlik
The 2-amine derivatives of 5-arylidene-3H-imidazol-4(5H)-one are a new class of bacterial efflux pump inhibitors, the chemical compounds that are able to restore antibiotic efficacy against multidrug resistant bacteria. 5-Arylidene-3H-imidazol-4(5H)-ones with a piperazine ring at position 2 reverse the mechanisms of multidrug resistance (MDR) of the particularly dangerous Gram-negative bacteria E. coli by inhibition of the efflux pump AcrA/AcrB/TolC (a main multidrug resistance mechanism in Gram-negative bacteria, consisting of a membrane fusion protein, AcrA, a Resistant-Nodulation-Division protein, AcrB, and an outer membrane factor, TolC)...
December 1, 2017: Acta Crystallographica. Section C, Structural Chemistry
https://www.readbyqxmd.com/read/29177163/surgical-therapy-of-sporadic-pancreatic-neuroendocrine-neoplasias-g1-g2
#3
REVIEW
Volker Fendrich, Detlef K Bartsch
Background: Pancreatic neuroendocrine neoplasias (pNENs) are uncommon but fascinating tumors with an annual incidence of 1 per 100,000 people. pNENs present either as functional tumors, causing specific hormonal syndromes like Zollinger-Ellison syndrome (ZES) or organic hyperinsulinism, or as non-functional pancreatic tumors (NF-pNENs). The natural history of pNENs is highly variable. 90% of all insulinomas or small NF- pNENs are readily curable by surgical resection. Most other functional and late detected NF-pNENs have a less favorable chance for cure...
October 2017: Visceral Medicine
https://www.readbyqxmd.com/read/29137966/clinical-outcomes-of-complex-real-world-diabetic-patients-treated-with-amphilimus-sirolimus-eluting-stents-or-zotarolimus-eluting-stents-a-single-center-registry
#4
Rik Rozemeijer, Daniela Benedetto, Adriaan O Kraaijeveld, Michiel Voskuil, Mèra Stein, Leo Timmers, Saskia Z Rittersma, Pierfrancesco Agostoni, Pieter A Doevendans, Pieter R Stella
OBJECTIVE: To assess clinical outcomes of Amphilimus Sirolimus-Eluting Stents (A-SES) as compared to Zotarolimus-Eluting Stents (ZES) in complex real-world diabetic patients. BACKGROUND: Patients with diabetes mellitus represent one of the most challenging scenarios with high rates of restenosis and stent thrombosis in the current era of drug-eluting stents. Hence, we assessed the safety of A-SES versus ZES in complex diabetic patients. METHODS: In this observational study, we analyzed all consecutive patients with diabetes mellitus referred to our center from November 2012 to November 2014...
October 26, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29118299/the-effect-of-cilostazol-on-the-angiographic-outcome-of-drug-eluting-coronary-stents-angiographic-analysis-of-the-cilon-t-influence-of-cilostazol-based-triple-antiplatelet-therapy-on-ischemi-complication-after-drug-eluting-stent-implantation-trial
#5
Jung-Won Suh, Seung-Pyo Lee, KyungWoo Park, Hyun-Jae Kang, Bon-Kwon Koo, Young-Seok Cho, Tae-Jin Youn, In-Ho Chae, Dong-Ju Choi, Seung-Woon Rha, Jang-Ho Bae, Taek-Geun Kwon, Jang-Whan Bae, Myeong-Chan Cho, Hyo-Soo Kim
It is not clear if anti-restonotic effect of cilostazol is consistent for different types of drug-eluting stents (DES).The purpose of this study was to compare the anti-proliferative effect of cilostazol between DAT and TAT with consideration of confounding influences of DES type.Nine hundred and fifteen patients were randomized to either dual antiplatelet therapy (DAT; aspirin and clopidogrel) or triple antiplatelet therapy (TAT; aspirin, clopidogrel, and cilostazol) in the previous CILON-T trial. After excluding 70 patients who received both or neither stents, we analyzed 845 patients who received exclusively PES or ZES, and compared in-stent late loss at 6 months between both antiplatelet regimens (DAT versus TAT)...
November 8, 2017: International Heart Journal
https://www.readbyqxmd.com/read/29111525/crystallographic-studies-of-cinnamamide-derivatives-as-a-means-of-searching-for-anticonvulsant-activity
#6
Ewa Żesławska, Wojciech Nitek, Henryk Marona, Agnieszka Gunia-Krzyżak
A cinnamamide (3-phenylprop-2-enamide) core is present in many pharmacologically active compounds. We report three new crystal structures of N-substituted cinnamamide derivatives which were screened for anticonvulsant activity, namely (R,S)-(2E)-N-(2-hydroxypropyl)-3-phenylprop-2-enamide, C12H15NO2, (1), (R,S)-(2E)-N-(1-hydroxybutan-2-yl)-3-phenylprop-2-enamide, C13H17NO2, (2), and (2E)-1-(4-hydroxypiperidin-1-yl)-3-phenylprop-2-en-1-one, C14H17NO2, (3). Compounds (1) and (2) crystallize in the Pbca space group with one molecule in the asymmetric unit, whereas compound (3) crystallizes in the P21/c space group with two molecules in the asymmetric unit...
November 1, 2017: Acta Crystallographica. Section C, Structural Chemistry
https://www.readbyqxmd.com/read/29104179/safety-of-6-month-dual-antiplatelet-therapy-after-second-generation-drug-eluting-stent-implantation-optima-c-randomized-clinical-trial-and-oct-substudy
#7
Byoung-Kwon Lee, Jung-Sun Kim, Oh-Huyn Lee, Pil-Ki Min, Young-Won Yoon, Bum-Kee Hong, Dong-Ho Shin, Tae-Soo Kang, Byung Ok Kim, Duk-Kyu Cho, Dong Woon Jeon, Sung-Ill Woo, Seonghoon Choi, Byung-Ryul Cho, Woong-Chol Kang, Seunghwan Kim, Byeong-Keuk Kim, Myeong-Ki Hong, Yangsoo Jang, Hyuck Moon Kwon
AIMS: There are few randomized studies of the optimal duration of dual antiplatelet therapy (DAPT) for patients who receive a second-generation drug-eluting stent (DES). METHODS AND RESULTS: A prospective, randomized, multicenter trial was performed at 10 medical centers. The 1,368 patients included in the study received a biolimus-eluting stent (BES) or zotarolimus-eluting stent (ZES). The primary outcome measured was the composite of major adverse cardiac events (MACEs), including cardiac death, myocardial infarction (MI), or ischemia-driven target lesion revascularization at the 12-month follow-up...
November 7, 2017: EuroIntervention
https://www.readbyqxmd.com/read/29020300/impact-of-design-of-coronary-stents-and-length-of-dual-antiplatelet-therapies-on-ischaemic-and-bleeding-events-a-network-meta-analysis-of-64-randomized-controlled-trials-and-102%C3%A2-735-patients
#8
Fabrizio D'Ascenzo, Mario Iannaccone, Gaelle Saint-Hilary, Maurizio Bertaina, Stefanie Schulz-Schüpke, Cheol Wahn Lee, Alaide Chieffo, Gerard Helft, Sebastiano Gili, Umberto Barbero, Giuseppe Biondi Zoccai, Claudio Moretti, Fabrizio Ugo, Maurizio D'Amico, Roberto Garbo, Gregg Stone, Sara Rettegno, Pierluigi Omedè, Federico Conrotto, Christian Templin, Antonio Colombo, Seung-Jung Park, Adnan Kastrati, David Hildick-Smith, Mauro Gasparini, Fiorenzo Gaita
Aims: The differential impact on ischaemic and bleeding events of the type of drug-eluting stent [durable polymer stents [DES] vs. biodegradable polymer stents vs. bioresorbable scaffolds (BRS)] and length of dual antiplatelet therapy (DAPT) remains to be defined. Methods and results: Randomized controlled trials comparing different types of DES and/or DAPT durations were selected. The primary endpoint was Major Adverse Cardiovascular Events (MACE) [a composite of death, myocardial infarction (MI), and target vessel revascularization]...
November 7, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29019150/the-zollinger-ellison-syndrome-is-there-a-role-for-somatostatin-analogues-in-the-treatment-of-the-gastrinoma
#9
REVIEW
Valentina Guarnotta, Chiara Martini, Maria Vittoria Davì, Genoveffa Pizza, Annamaria Colao, Antongiulio Faggiano
PURPOSE: Analyze the role of somatostatin analogues (SSAs) in the treatment of sporadic and MEN1-related gastrinomas, trying to define whether recent trials have changed the landscape of gastrinoma therapy. METHODS: We evaluate the rationale of SSA use in the treatment of gastrinomas, summarize the current literature concerning the effect of SSAs on the control of Zollinger-Ellison syndrome (ZES) and gastrinomas tumor progression and discuss their role in the most recent guidelines...
October 10, 2017: Endocrine
https://www.readbyqxmd.com/read/28994655/functional-comparison-between-buma-supreme-biodegradable-polymer-sirolimus-eluting-and-durable-polymer-zotarolimus-eluting-coronary-stents-using-quantitative-flow-ratio-pioneer-qfr-substudy
#10
Taku Asano, Yuki Katagiri, Carlos Collet, Erhan Tenekecioglu, Yosuke Miyazaki, Yohei Sotomi, Giovanni Amoroso, Adel Aminian, Salvatore Brugaletta, Mathias Vrolix, Rosana Hernandez-Antolín, Pim van de Harst, Andres Iñiguez, Luc Janssens, Pieter Smits, Joanna J Wykrzykowska, Vasco Gama Ribeiro, Helder Periera, Pedro Canas da Silva, Jan J Piek, Johan H C Reiber, Clemens von Birgelen, Manel Sabaté, Yoshinobu Onuma, Patrick W Serruys
AIMS: Quantitative Flow Ratio (QFR) based on 3-dimensional quantitative coronary angiography (3D-QCA) is a novel method to assess the physiological functionality after treatment with stents. The current study aimed to evaluate the difference in physiological functionality 9 months after implantation of a bioresorbable polymer-based sirolimus-eluting stent with an electrografting base layer (BuMA Supreme: B-SES) versus a durable polymer-based zotarolimus-eluting stent (Resolute: R-ZES)...
October 10, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28949124/diagnosis-and-management-of-zollinger-ellison-syndrome-in-2017
#11
Claudio DE Angelis, Pablo Cortegoso Valdivia, Ludovica Venezia, Mauro Bruno, Rinaldo Pellicano
Zollinger-Ellison Syndrome (ZES) is a clinical syndrome characterized by gastric acid hypersecretion due to the ectopic secretion of gastrin by a gastrinoma, a neuroendocrine tumor (NET) which mostly develops in the duodenum and in the pancreas. This syndrome was first described by Zollinger and Ellison in 1964; if left untreated, ZES can lead to multiple complications mainly due to gastric hypersecretion and some patients can suffer from the complications of an advanced metastatic disease. Although its clinical features are considered typical, the diagnosis of ZES is often challenging for the clinician...
September 25, 2017: Minerva Endocrinologica
https://www.readbyqxmd.com/read/28923787/first-in-man-randomized-comparison-of-buma-supreme-biodegradable-polymer-sirolimus-eluting-versus-durable-polymer-zotarolimus-eluting-coronary-stents-the-pioneer-trial
#12
Clemens von Birgelen, Taku Asano, Giovanni Amoroso, Adel Aminian, Salvatore Brugaletta, Mathias Vrolix, Rosana Hernandez-Antolín, Pim van de Harst, Andres Iñiguez, Luc Janssens, Pieter C Smits, Joanna J Wykrzykowska, Vasco Gama Ribeiro, Helder Periera, Pedro Canas da Silva, Jan J Piek, Yoshinobu Onuma, Patrick W Serruys, Manel Sabaté
AIMS: A second iteration of a sirolimus-eluting stent (SES) that has a biodegradable PLGA-polymer coating with electrografting base layer on a thin-strut (80µm) cobalt-chromium platform (BuMA Supreme; SINOMED, Tianjin, China) has been developed. This first-in-man trial assessed the efficacy and safety of the novel device. METHODS AND RESULTS: This randomized, multi-center, single-blinded, non-inferiority trial compared BuMA Supreme SES versus contemporary durable polymer zotarolimus-eluting stents (ZES) in terms of angiographic in-stent late lumen loss (LLL) at 9-months follow-up as the primary endpoint...
September 19, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28846542/impact-of-bioresorbable-versus-permanent-polymer-on-long-term-vessel-wall-inflammation-and-healing-a-comparative-drug-eluting-stent-experimental-study
#13
Gregory J Wilson, Jennifer McGregor, Gerard Conditt, Masahiko Shibuya, Natalia Sushkova, Michael J Eppihimer, Steven P Hawley, Serge D Rousselle, Barbara A Huibregtse, Keith D Dawkins, Juan F Granada
AIMS: Drug-Eluting Stents (DES) have evolved to bioresorbable polymers as a method of drug delivery. The impact of bioresorbable polymer on long-term neointimal formation, inflammation, and healing has not been fully characterized. METHODS AND RESULTS: A comparative DES study was performed in the Familial Hypercholesterolemic Swine model of coronary stenosis. Permanent-polymer DES (zotarolimus- eluting [ZES] or everolimus- eluting [EES]) were compared to bioresorbable polymer everolimus-eluting stents (BP-EES) and BMS...
August 29, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28794001/randomized-comparison-of-ridaforolimus-and-zotarolimus-eluting-coronary-stents-in-patients-with-coronary-artery-disease-primary-results-from-the-bionics-trial-bionir-ridaforolimus-eluting-coronary-stent-system-in-coronary-stenosis
#14
RANDOMIZED CONTROLLED TRIAL
David E Kandzari, Pieter C Smits, Michael P Love, Ori Ben-Yehuda, Shmuel Banai, Simon D Robinson, Michael Jonas, Ran Kornowski, Rodrigo Bagur, Andres Iniguez, Haim Danenberg, Robert Feldman, Rajiv Jauhar, Harish Chandna, Manish Parikh, Gidon Y Perlman, Mercedes Balcells, Peter Markham, Melek Ozgu Ozan, Philippe Genereux, Elazer R Edelman, Martin B Leon, Gregg W Stone
BACKGROUND: The safety and efficacy of a novel cobalt alloy-based coronary stent with a durable elastomeric polymer eluting the antiproliferative agent ridaforolimus for treatment of patients with coronary artery disease is undetermined. METHODS: A prospective, international 1:1 randomized trial was conducted to evaluate in a noninferiority design the relative safety and efficacy of ridaforolimus-eluting stents (RESs) and slow-release zotarolimus-eluting stents among 1919 patients undergoing percutaneous coronary intervention at 76 centers...
October 3, 2017: Circulation
https://www.readbyqxmd.com/read/28776139/catching-the-zebra-clinical-pearls-and-pitfalls-for-the-successful-diagnosis-of-zollinger-ellison-syndrome
#15
REVIEW
Aaron H Mendelson, Mark Donowitz
Zollinger-Ellison syndrome (ZES) results from an ectopic gastrin-secreting tumor leading to peptic ulcer disease, reflux, and chronic diarrhea. While early recognition portends an excellent prognosis with >80% survival at 15 years, symptoms are often nonspecific making the diagnosis difficult to establish. Diagnosis involves a series of tests, including fasting gastrin, gastric pH, chromogranin A, and secretin stimulation. Performing these tests in the correct sequence and at the proper time is essential to avoid inaccurate results...
August 3, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28743907/long-term-2-5-years-adverse-clinical-outcomes-associated-with-zes-versus-ses-pes-and-ees-a-meta-analysis
#16
Pravesh Kumar Bundhun, Akash Bhurtu, Manish Pursun, Mohammad Zafooruddin Sani Soogund, Abhishek Rishikesh Teeluck, Wei-Qiang Huang
Several previously published trials comparing Zotarolimus Eluting Stents (ZES) with Sirolimus Eluting Stents (SES), Paclitaxel Eluting Stents (PES) or Everolimus Eluting Stents (EES) at a follow up period of 1 year, were continually being followed up in order to assess the long-term outcomes. In this meta-analysis, we aimed to compare the long-term (2-5 years) adverse clinical outcomes which were associated with ZES versus SES, PES and EES following Percutaneous Coronary Intervention (PCI). Risk Ratios (RR) with 95% Confidence Intervals (CIs) were generated and the analysis was carried out by the RevMan 5...
July 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28692458/angiographic-and-clinical-outcomes-after-recanalization-of-coronary-chronic-total-occlusions-with-the-orsiro-sirolimus-eluting-stent-compared-with-the-resolute-zotarolimus-eluting-stent
#17
Sinisa Markovic, Michael Lützner, Sergiu Dragomir, Wolfgang Rottbauer, Jochen Wöhrle
OBJECTIVE: The third generation drug eluting Orsiro stent had shown already promising results in non-complex lesions. BACKGROUND: We evaluated angiographic and 24 month clinical results of the sirolimus eluting Orsiro stents (O-SES) after recanalization of coronary chronic total occlusions (CTO). Results were compared with the zotarolimus eluting Resolute Integrity (R-ZES). METHODS: In a prospective series 57 patients were treated with a R-ZES followed by 74 patients treated with a O-SES stent...
August 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28677608/conformational-study-of-the-3-6-dihydro-2h-1-4-oxazin-2-one-fragment-in-8-tert-butyl-7-methoxy-8-methyl-9-oxa-6-azaspiro-4-5-decane-2-10-dione-stereoisomers
#18
Ewa Żesławska, Anna Jakubowska, Wojciech Nitek
Unnatural cyclic α-amino acids play an important role in the search for biologically active compounds and macromolecules. Enantiomers of natural amino acids with a D configuration are not naturally encoded, but can be chemically synthesized. The crystal structures of two enantiomers obtained by a method of stereoselective synthesis, namely (5R,8S)-8-tert-butyl-7-methoxy-8-methyl-9-oxa-6-azaspiro[4.5]decane-2,10-dione, (1), and (5S,8R)-8-tert-butyl-7-methoxy-8-methyl-9-oxa-6-azaspiro[4.5]decane-2,10-dione, (2), both C14H21NO4, were determined by X-ray diffraction...
July 1, 2017: Acta Crystallographica. Section C, Structural Chemistry
https://www.readbyqxmd.com/read/28610782/assessment-of-treatment-response-by-colony-forming-units-time-to-culture-positivity-and-the-molecular-bacterial-load-assay-compared-in-a-mouse-tuberculosis-model
#19
Gerjo J de Knegt, Laura Dickinson, Henry Pertinez, Dimitrios Evangelopoulos, Timothy D McHugh, Irma A J M Bakker-Woudenberg, Gerry R Davies, Jurriaan E M de Steenwinkel
The aim of the study is to compare counting of colony forming units (CFU), the time to positivity (TTP) assay and the molecular bacterial load (MBL) assay, and explore whether the last assays can detect a subpopulation which is unable to grown on solid media. CFU counting, TTP and the MBL assay were used to determine the mycobacterial load in matched lung samples of a murine tuberculosis model. Mice were treated for 24 weeks with 4 treatment arms: isoniazid (H) - rifampicin (R) - pyrazinamide (Z), HRZ-Streptomycin (S), HRZ - ethambutol (E) or ZES...
July 2017: Tuberculosis
https://www.readbyqxmd.com/read/28544782/rationale-and-design-of-amphilimus-sirolimus-eluting-stents-versus-zotarolimus-eluting-stents-in-all-comers-requiring-percutaneous-coronary-intervention-recre8-a-multicenter-randomized-clinical-trial
#20
Rik Rozemeijer, Mèra Stein, Peter Frambach, Michiel Voskuil, Adriaan O Kraaijeveld, Ramón Rodríguez-Olivares, Leo Timmers, Bruno Pereira, Saskia Z Rittersma, Pierfrancesco Agostoni, Pieter A Doevendans, Pieter R Stella
BACKGROUND: Amphilimus sirolimus-eluting stents (A-SES) represent a novel elution technology in the current era of drug-eluting stents with promising results in patients with diabetes mellitus. At present no large trial has been designed to evaluate clinical outcomes of A-SES as compared to new-generation drug-eluting stents in unselected patients. Accordingly, we designed this trial to evaluate clinical noninferiority of A-SES as compared with zotarolimus-eluting stents (ZES) in a real-world, all-comers setting...
May 22, 2017: Catheterization and Cardiovascular Interventions
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