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Duodenal Gangliocytic paraganglioma

Yuichi Sato, Satoru Hashimoto, Ken-Ichi Mizuno, Manabu Takeuchi, Shuji Terai
Gastrointestinal neuroendocrine tumors (GI-NETs) are rare neoplasms, like all NETs. However, the incidence of GI-NETS has been increasing in recent years. Gastric NETs (G-NETs) and duodenal NETs (D-NETs) are the common types of upper GI-NETs based on tumor location. G-NETs are classified into three distinct subgroups: type I, II, and III. Type I G-NETs, which are the most common subtype (70%-80% of all G-NETs), are associated with chronic atrophic gastritis, including autoimmune gastritis and Helicobacter pylori associated atrophic gastritis...
August 14, 2016: World Journal of Gastroenterology: WJG
Zhengping Zhuang, Chunzhang Yang, Ales Ryska, Yuan Ji, Yingyong Hou, Sky D Graybill, Petra Bullova, Irina A Lubensky, Günter Klöppel, Karel Pacak
No abstract text is available yet for this article.
May 2016: Endocrine-related Cancer
Alessandro Vanoli, Stefano La Rosa, Catherine Klersy, Federica Grillo, Luca Albarello, Frediano Inzani, Roberta Maragliano, Rachele Manca, Ombretta Luinetti, Massimo Milione, Claudio Doglioni, Guido Rindi, Carlo Capella, Enrico Solcia
BACKGROUND: Several types of neuroendocrine neoplasms (NENs) have been described in the duodenal tract, from low grade tumors (NETs) to high grade neuroendocrine carcinomas (NECs). A comprehensive analysis of histology, hormonal profile and prognostic parameters of a sufficiently large duodenal NEN series to cover all main kinds of neoplasms is however lacking. METHODS: We collected a retrospective series of 203 duodenal wall and ampullary region NENs, from six specialized endocrine pathology centers...
February 25, 2016: Neuroendocrinology
Hyung Kyu Park, Hye Seung Han
Gangliocytic paraganglioma is a rare tumor that occurs most commonly in the second portion of the duodenum. It is characterized by its triphasic cellular differentiation: epithelioid neuroendocrine cells, spindle cells with Schwann cell differentiation, and ganglion cells. Most gangliocytic paragangliomas are considered benign and are amenable to local excision. However, to our knowledge, 23 cases with lymph node metastasis have been reported, 1 case of bone metastasis, and 2 cases of liver metastases. Predictive factors that have been suggested for lymph node metastasis include size (larger than 2 cm), young age, and tumors exceeding the submucosal layer...
January 2016: Archives of Pathology & Laboratory Medicine
Bo Wang, Yinying Zou, Han Zhang, Liming Xu, Xiaojun Jiang, Ke Sun
We report two cases of Gangliocytic paraganglioma (GP), one of which was accompanied by lymph node metastasis. Histologically, the tumor was composed of three morphologically distinct cell populations: spindle cells, ganglion-like cells and epithelioid cells. The epithelioid cells were positive for cytokeratin (AE1/AE3), synaptophysin (Syn), chromogranin A (CgA), CD56 and progesterone receptor (PR). Ganglion-like cell types showed positive reactivity for Syn and CD56. In contrast, the spindle-shaped cells showed positive reactivity for S-100...
2015: International Journal of Clinical and Experimental Pathology
Iolanda Ribeiro, Carlos Fernandes, Sónia Fernandes, Luísa Proença, Joana Silva, Ana Ponte, Jaime Rodrigues, João Carvalho
No abstract text is available yet for this article.
November 2016: Gastroenterología y Hepatología
Pradnya V Manglekar, Vijayshree Bhide, Nachiket A Dubale, Amol Bapaye
No abstract text is available yet for this article.
November 2015: Gastrointestinal Endoscopy
Yoichiro Okubo, Tetsuo Nemoto, Megumi Wakayama, Naobumi Tochigi, Minoru Shinozaki, Takao Ishiwatari, Kyoko Aki, Masaru Tsuchiya, Hajime Aoyama, Kanade Katsura, Takeshi Fujii, Takashi Nishigami, Tomoyuki Yokose, Yasuo Ohkura, Kazutoshi Shibuya
BACKGROUND: Gangliocytic paraganglioma (GP) is an extremely rare benign tumor that commonly arises from the second part of the duodenum. Since GP exhibit neither prominent mitotic activity nor Ki-67 immunoreactivity, this tumor is often misdiagnosed as neuroendocrine tumor (NET) G1 (carcinoid tumor). However, patients with GP may have a better prognosis than patients with NET G1. This fact emphasizes the importance of differentiating GP from NET G1, but few studies have reported the epidemiology and histopathology of GP because of its rarity...
2015: BMC Cancer
Alina Boeriu, Daniela Dobru, Rareș Georgescu, Simona Mocan, Cristian Boeriu
Duodenal neuroendocrine tumors (NETs) are rare tumors, consisting of five different types of tumors. In many cases, they may be asymptomatic, leading to delay in diagnosis. Clinical symptoms are related to local tumor growth and mucosal ulceration. We report a 38-year old man with duodenal gangliocytic paraganglioma causing overt upper gastrointestinal bleeding and anemia. We describe specific clinical and histopathological features of the tumor, and review the diagnostic and therapeutic strategy. Gangliocytic paragangliomas are regarded as benign tumors...
March 2015: Journal of Gastrointestinal and Liver Diseases: JGLD
Tyler J Loftus, Jesse L Kresak, David H Gonzalo, George A Sarosi, Kevin E Behrns
INTRODUCTION: Gangliocytic paraganglioma is a rare tumor that is most commonly located in the duodenum. At presentation, it may be confused with a gastrointestinal stromal tumor (GIST), but distinguishing between these tumors is critical because the natural history and treatment of these two tumors differs markedly. Duodenal gangliocytic paraganglioma typically exhibits benign behavior with occasional regional lymph node metastasis and no reports of tumor associated deaths. Recurrence after resection is rare...
2015: International Journal of Surgery Case Reports
Nicholas Lau, Danielle Hari, Samuel French
We present a case of a 49-year-old woman who underwent a pancreaticoduodenectomy for symptomatic treatment of an obstructive periampullary duodenal mass initially found on CT imaging. Histologically, the tumor showed a triphasic pattern including small round cells, a spindle-cell component and ganglion cells of varying size. Furthermore, the tumor was surrounded by a proliferation of pancreatic ducts. These features led to the diagnosis of a gangliocytic paraganglioma arising in an ectopic pancreas. Sections of the tumor were then stained for SOX10, a neural crest transcription factor, and it was shown to be positive in the ganglion cells...
February 2015: Experimental and Molecular Pathology
Bin Li, Yang Li, Xiao-Ying Tian, Bo-Ning Luo, Zhi Li
Gangliocytic paraganglioma (GP) is rare and has been regarded as benign in general with a good prognosis. We present a patient with duodenal GP showing a malignant and lethal clinical course. A 47-year-old male patient was found to have a duodenal tumor and enlarged regional lymph nodes. The patient initially underwent a pancreaticoduodenectomy to resect the tumor and involved lymph nodes completely. Histological and immunohistochemical analyses showed findings typical of GP. However, the distant metastatic lesions in the liver and pelvic cavity were rapidly observed after surgery...
November 7, 2014: World Journal of Gastroenterology: WJG
Stephanie Downs-Canner, Wald J Van der Vliet, Stijn J J Thoolen, Brian A Boone, Amer H Zureikat, Melissa E Hogg, David L Bartlett, Mark P Callery, Tara S Kent, Herbert J Zeh, A James Moser
INTRODUCTION: Benign duodenal and periampullary tumors are uncommon lesions requiring careful attention to their complex anatomic relationships with the major and minor papillae as well as the gastric outlet during surgical intervention. While endoscopy is less morbid than open resection, many lesions are not amenable to endoscopic removal. Robotic surgery offers technical advantages above traditional laparoscopy, and we demonstrate the safety and feasibility of this approach for a variety of duodenal lesions...
February 2015: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
R Bhattacharyya, P Bhandari
INTRODUCTION: It is very difficult to establish an accurate diagnosis for upper GI submucosal tumours. Biopsy during endoscopy cannot go deep enough. EUS is unable to give a tissue diagnosis. The risks of surgical resection are higher than the benefits as the lesion may very well be benign. As a result most of these patients keep having endoscopic surveillance as 'possible' GISTs. METHODS: A retrospective cohort study of patients undergoing ESD for upper GI submucosal tumours...
June 2014: Gut
Ju-Il Yang, Jung-Sik Choi, Ga-Hee Lee, Byeong-Woo Kim, Seok-Jun Moon, Mi Seon Kang, Hyo Jung Ahn
Gangliocytic paragangliomas (GPs) are rare tumors of the duodenum, presenting as single sessile or pedunculated polypoid masses. Clinical manifestations of duodenal GPs can vary from an incidental finding at endoscopy to frequent upper gastrointestinal bleeding caused by mucosal ulceration and abdominal pain. GPs are considered benign, but the disease can recur and spread to regional lymph nodes. A 41-year-old female presented with abdominal pain. Upper gastrointestinal endoscopy revealed a subepithelial tumor of the ampulla of Vater in the second portion of the duodenum...
May 2014: Korean Journal of Internal Medicine
Fabiana Tatangelo, Monica Cantile, Alessia Pelella, Nunzia Simona Losito, Giosuè Scognamiglio, Franco Bianco, Andrea Belli, Gerardo Botti
UNLABELLED: Gastroenteropancreatic neuroendocrine tumors are the most incident neuroendocrine tumors. In the new WHO classification (2010) the embryological derivation of each neoplastic entity is one of the most important parameters. Gangliocytic Paraganglioma is a tumor originating in the hindgut, a rare neoplasm, generally affecting the second portion of the duodenum, the majority of which are benign.Cases of gangliocytic paraganglioma with local metastasis or local recurrence have also been reported...
2014: Diagnostic Pathology
Natalia I Asimakopoulou, Panteleimon E Papakonstantinou, Konstantinos G Lasithiotakis, Ioannis A Mouzas, Maria E Daskalogiannaki, Maria N Tzardi, George E Chalkiadakis
CONTEXT: Gangliocytic paraganglioma is a rare tumor, almost always located in the second portion of the duodenum, and manifested with upper gastrointestinal bleeding and abdominal pain. To date, only one case of duodenal gangliocytic paraganglioma presented with recurrent acute pancreatitis has been reported in the literature. CASE REPORT: We present a 72-year-old woman admitted to the hospital due to recurrent episodes of acute pancreatitis. Paraclinical examinations showed a polypoid mass in the second portion of duodenum which was removed surgically by local excision...
March 2014: JOP: Journal of the Pancreas
Se Jeong Park, Do Hoon Kim, Hyun Lim, Jeong Hoon Lee, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon Yong Jung, Jin-Ho Kim, Ji Young Park
Gangliocytic paraganglioma (GP) is a rare, benign tumor which is usually found in the duodenum. We here report four recent cases of GP, with successful endoscopic resection in three cases, including a lesion on the ampulla of Vater. In all cases, each lesion had a stalk that facilitated removal using an endoscopic approach. Endoscopic mucosal resection is a feasible and safe treatment if the location, depth, and lymph node status are all favorable and is also helpful for definite diagnosis of unknown duodenal mass...
February 2014: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
S M Amin, N Wewer Albrechtsen, J Forster, I Damjanov
Gangliocytic paraganglioma (GP) is a rare benign neuroendocrine tumour found most often in the duodenum. To our knowledge, only a dozen cases of possibly malignant duodenal GP with local lymph node metastasis and only one case with liver metastasis have previously been published. Herein, we report an unusual case of GP of the duodenum spreading to the retropancreatic space and metastatic to the liver and lymph nodes. Additionally, the present tumour secreted pancreatic polypeptide (PP) which was detected in the serum during the follow-up period...
June 2013: Pathologica
Filip Čečka, Bohumil Jon, Rudolf Repák, Aleš Kohout, Zdeněk Šubrt, Alexander Ferko
No abstract text is available yet for this article.
November 2012: Canadian Journal of Gastroenterology, Journal Canadien de Gastroenterologie
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