keyword
MENU ▼
Read by QxMD icon Read
search

Age related macular degeneration

keyword
https://www.readbyqxmd.com/read/28231566/one-year-outcomes-of-1-pro-re-nata-versus-3-pro-re-nata-intravitreal-aflibercept-injection-for-neovascular-age-related-macular-degeneration
#1
Kei Takayama, Hiroki Kaneko, Tadasu Sugita, Ruka Maruko, Kyoko Hattori, Eimei Ra, Kenichi Kawano, Keiko Kataoka, Yasuki Ito, Hiroko Terasaki
PURPOSE: We compared 1-year outcomes of 1 + pro re nata (PRN) versus 3 + PRN of intravitreal aflibercept injection (IAI) for age-related macular degeneration (AMD). METHODS: Forty-two eyes with naïve AMD received 3 + PRN IAI treatment and 47 eyes with naïve AMD received 1 + PRN IAI treatment. Visual acuity (VA), central retinal thickness (CRT), and central choroidal thickness (CCT) and number of administered IAIs during 12 months were compared. RESULTS: VAs improved, and CRTs reduced significantly at any given month from baseline in both groups (p < 0...
February 24, 2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/28229127/the-application-of-retinal-fundus-camera-imaging-in-dementia-a-systematic-review
#2
REVIEW
Sarah McGrory, James R Cameron, Enrico Pellegrini, Claire Warren, Fergus N Doubal, Ian J Deary, Baljean Dhillon, Joanna M Wardlaw, Emanuele Trucco, Thomas J MacGillivray
INTRODUCTION: The ease of imaging the retinal vasculature, and the evolving evidence suggesting this microvascular bed might reflect the cerebral microvasculature, presents an opportunity to investigate cerebrovascular disease and the contribution of microvascular disease to dementia with fundus camera imaging. METHODS: A systematic review and meta-analysis was carried out to assess the measurement of retinal properties in dementia using fundus imaging. RESULTS: Ten studies assessing retinal properties in dementia were included...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28228282/complement-factor-h-inhibits-cd47-mediated-resolution-of-inflammation
#3
Bertrand Calippe, Sebastien Augustin, Fanny Beguier, Hugo Charles-Messance, Lucie Poupel, Jean-Baptiste Conart, Shulong J Hu, Sophie Lavalette, Alexandre Fauvet, Julie Rayes, Olivier Levy, William Raoul, Catherine Fitting, Thomas Denèfle, Matthew C Pickering, Claire Harris, Sylvie Jorieux, Patrick M Sullivan, José-Alain Sahel, Philippe Karoyan, Przemyslaw Sapieha, Xavier Guillonneau, Emmanuel L Gautier, Florian Sennlaub
Variants of the CFH gene, encoding complement factor H (CFH), show strong association with age-related macular degeneration (AMD), a major cause of blindness. Here, we used murine models of AMD to examine the contribution of CFH to disease etiology. Cfh deletion protected the mice from the pathogenic subretinal accumulation of mononuclear phagocytes (MP) that characterize AMD and showed accelerated resolution of inflammation. MP persistence arose secondary to binding of CFH to CD11b, which obstructed the homeostatic elimination of MPs from the subretinal space mediated by thrombospsondin-1 (TSP-1) activation of CD47...
February 21, 2017: Immunity
https://www.readbyqxmd.com/read/28228273/compliments-of-factor-h-what-s-in-it-for-amd
#4
Mary J Mattapallil, Rachel R Caspi
Genetic variations in complement factor H (CFH) confer greater risk for age-related macular degeneration (AMD). In this issue of Immunity, Calippe et al. (2017) uncover a non-canonical role for CFH in the inhibition of mononuclear phagocyte elimination from sub-retinal lesions, providing insight into the pathophysiology of AMD associated with CFH variants.
February 21, 2017: Immunity
https://www.readbyqxmd.com/read/28227879/wearable-diagnostic-system-for-age-related-macular-degeneration
#5
N Mohaghegh, E Ghafar Zadeh, S Magierowski, N Mohaghegh, E Ghafar Zadeh, S Magierowski, N Mohaghegh, E Ghafar Zadeh, S Magierowski
This paper presents a novel head-mounted point-of-care diagnostic system for detection and continuous monitoring of Age-related Macular Degeneration (AMD). This wearable embedded open-source platform enables accurate monitoring of AMD by taking advantage of multiple standard graphical interface techniques such as Amsler Grid, Threshold Amsler Grid, Macular Computerized Psychophysical Test and Preferential Hyperacuity Perimeter (PHP). Here, we describe the proposed multi-Grid or so-called NGRID software and elaborate on the hardware prototype...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226753/determining-the-difference-in-eyegaze-measurements-in-individuals-with-age-related-macular-degeneration
#6
Huiying Liu, Damon Wong, Ai Ping Yow, Yanwu Xu, Fengshou Yin, Augustinus Laude, Tock Han Lim, Huiying Liu, Damon Wong, Ai Ping Yow, Yanwu Xu, Fengshou Yin, Augustinus Laude, Tock Han Lim, Augustinus Laude, Huiying Liu, Tock Han Lim, Fengshou Yin, Yanwu Xu, Damon Wong, Ai Ping Yow
Age-related Macular Degeneration (AMD) is one of the leading causes of blindness in the elderly. Visual loss associated with AMD often results in a central scotoma which is an alteration in the central vision, leading to distortion or loss of vision. Current methods of detecting AMD are typically manual, require holding fixation and an external response trigger. In this paper, we propose the use of eyegaze tracking to detect for the presence of AMD, using a simple set of test patterns. Experimental results show that the derived eyegaze measurements can help to identify individuals with AMD from healthy individuals...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225799/sf-6d-utility-values-for-the-better-and-worse-seeing-eye-for-health-states-based-on-the-snellen-equivalent-in-patients-with-age-related-macular-degeneration
#7
Martijn S Visser, Sankha Amarakoon, Tom Missotten, Reinier Timman, Jan J Busschbach
OBJECTIVE: Economic evaluations in wet age-related macular degeneration (ARMD) is hampered as often utility values for solely one eye are used, mostly the better-seeing eye (BSE). Moreover, frequently chosen methods rely on patient values and/or disease specific measures, while economic evaluations prefer generic quality of life (QoL) measures based on societal preferences. The generic QoL utility instrument EQ-5D has shown to be insensitive for differences in visual acuity. The aim of this study was therefore to provide societal utility values, using the generic SF-6D, for health states acknowledging both BSE and worse-seeing eye (WSE)...
2017: PloS One
https://www.readbyqxmd.com/read/28225373/outer-retinal-tubulation-a-case-series
#8
Leticia A Rousso, Julie A Rodman, Brad Sutton, Diana L Shechtman
PURPOSE: The advent of spectral domain optical coherence tomography has led to superb imaging capabilities in addition to enhanced visualization of the retinal layers. Such advancements have led to the identification of a variety of new retinal conditions, including outer retinal tubulations (ORTs). ORTs are ovoid hyporeflective spaces located in the outer retina. The pathogenesis is unclear but seems to involve sublethal injury to the photoreceptors leading to a compensatory reorganization of the photoreceptor layer with the neighboring ellipsoid zone resulting in a hyperreflective border surrounding a central lumen...
March 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/28225371/measurement-of-perceived-stress-in-age-related-macular-degeneration
#9
Bradley E Dougherty, San-San L Cooley, Frederick H Davidorf
PURPOSE: To validate the Perceived Stress Scale (PSS) in patients with age-related macular degeneration (AMD) using Rasch analysis. METHODS: Study participants with AMD were recruited from the retina service of the Department of Ophthalmology at the Ohio State University during clinical visits for treatment or observation. Visual acuity with habitual distance correction was assessed. A 10-item version of the PSS was administered in large print or by reading the items to the patient...
March 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/28223776/idiopathic-polypoidal-choroidal-vasculopathy-in-thai-patients-with-clinical-and-angiographic-choroidal-neovascularization
#10
Chavakij Bhoomibunchoo, Yosanan Yospaiboon, Somanus Thoongsuwan, Duangnate Rojanaporn, Nawat Watanachai, Pichai Jirarattanasopa, Nattapon Wongcumchang, Atchara Amphornphruet, Sritatath Vongkulsiri, Eakkachai Arayangkoon
OBJECTIVE: This study aimed to study the prevalence and characteristics of idiopathic polypoidal choroidal vasculopathy (IPCV) in Thai patients with clinical and angiographic choroidal neovascularization (CNV). PATIENTS AND METHODS: A consecutive case study of 140 patients presenting with CNV was conducted in nine large referral eye centers throughout Thailand. The demographic data, fundus photographs, fundus fluorescein angiography and indocyanine green angiography of the patients were analyzed...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28223773/erratum-a-single-arm-investigator-initiated-study-of-the-efficacy-safety-and-tolerability-of-intravitreal-aflibercept-injection-in-subjects-with-exudative-age-related-macular-degeneration-previously-treated-with-ranibizumab-or-bevacizumab-assess-study-12-month
#11
https://www.readbyqxmd.com/read/28223209/langmuir-schaefer-film-deposition-onto-honeycomb-porous-films-for-retinal-tissue-engineering
#12
Maria Teresa Calejo, Tanja Ilmarinen, Elina Vuorimaa-Laukkanen, Elina Talvitie, Hanna M Hakola, Heli Skottman, Minna Kellomäki
: Age-related macular degeneration (AMD) is the leading cause of vision loss in senior citizens in the developed world. The disease is characterised by the degeneration of a specific cell layer at the back of the eye - the retinal pigment epithelium (RPE), which is essential in retinal function. The most promising therapeutic option to restore the lost vision is considered to be RPE cell transplantation. This work focuses on the development of biodegradable biomaterials with similar properties to the native Bruch's membrane as carriers for RPE cells...
February 18, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28221254/long-term-remission-of-neovascular-age-related-macular-degeneration-with-as-needed-anti-vascular-endothelial-growth-factor-therapy
#13
Ilkay Kilic Muftuoglu, Mostafa Alam, Qi Sheng You, Raouf Gaber, Hema L Ramkumar, Nadia Mendoza, Amit Meshi, William R Freeman
PURPOSE: To determine the presenting characteristics of patients with neovascular age-related macular degeneration with long-term remission (LTR), which was defined as the absence of intraretinal/subretinal fluid, or hemorrhage, and absence of leakage on fluorescein angiography for longer than 6 months while on as-needed antivascular endothelial growth factor treatment. METHODS: The presenting characteristics of patients with LTR were compared with a control group including 32 eyes of 28 age-, gender-, and ethnicity-matched patients who did not achieve LTR...
February 17, 2017: Retina
https://www.readbyqxmd.com/read/28220790/in-vivo-genome-editing-with-a-small-cas9-orthologue-derived-from-campylobacter-jejuni
#14
Eunji Kim, Taeyoung Koo, Sung Wook Park, Daesik Kim, Kyoungmi Kim, Hee-Yeon Cho, Dong Woo Song, Kyu Jun Lee, Min Hee Jung, Seokjoong Kim, Jin Hyoung Kim, Jeong Hun Kim, Jin-Soo Kim
Several CRISPR-Cas9 orthologues have been used for genome editing. Here, we present the smallest Cas9 orthologue characterized to date, derived from Campylobacter jejuni (CjCas9), for efficient genome editing in vivo. After determining protospacer-adjacent motif (PAM) sequences and optimizing single-guide RNA (sgRNA) length, we package the CjCas9 gene, its sgRNA sequence, and a marker gene in an all-in-one adeno-associated virus (AAV) vector and produce the resulting virus at a high titer. CjCas9 is highly specific, cleaving only a limited number of sites in the human or mouse genome...
February 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/28220249/-adjuvant-radiotherapy-during-anti-vegf-in-neovascular-age-related-macular-degeneration
#15
P Rating, M-A Freimuth, M Stuschke, N Bornfeld
Single adjuvant radiotherapy during anti-VEGF therapy could be in certain indications an alternative to the gold standard of sole intravitreal anti-VEGF drug injection in neovascular age-related macular degeneration. First clinical trials showed efficacy due to reduction of anti-VEGF injection numbers by 100 kV collimated beam radiotherapy. After consideration and performance of adjuvant radiotherapy, results of the course should be centrally registered in order to carry out further analysis.
February 20, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28217714/dr-hagis-a-fundus-image-database-for-the-automatic-extraction-of-retinal-surface-vessels-from-diabetic-patients
#16
Sven Holm, Greg Russell, Vincent Nourrit, Niall McLoughlin
A database of retinal fundus images, the DR HAGIS database, is presented. This database consists of 39 high-resolution color fundus images obtained from a diabetic retinopathy screening program in the UK. The NHS screening program uses service providers that employ different fundus and digital cameras. This results in a range of different image sizes and resolutions. Furthermore, patients enrolled in such programs often display other comorbidities in addition to diabetes. Therefore, in an effort to replicate the normal range of images examined by grading experts during screening, the DR HAGIS database consists of images of varying image sizes and resolutions and four comorbidity subgroups: collectively defined as the diabetic retinopathy, hypertension, age-related macular degeneration, and Glaucoma image set (DR HAGIS)...
January 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/28216098/potential-influences-of-complement-factor-h-in-autoimmune-inflammatory-and-thrombotic-disorders
#17
Janez Ferluga, Lubna Kouser, Valarmathy Murugaiah, Robert B Sim, Uday Kishore
Complement system homeostasis is important for host self-protection and anti-microbial immune surveillance, and recent research indicates roles in tissue development and remodelling. Complement also appears to have several points of interaction with the blood coagulation system. Deficiency and altered function due to gene mutations and polymorphisms in complement effectors and regulators, including Factor H, have been associated with familial and sporadic autoimmune inflammatory - thrombotic disorders, in which autoantibodies play a part...
February 16, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28214594/association-between-light-at-night-melatonin-secretion-sleep-deprivation-and-the-internal-clock-health-impacts-and-mechanisms-of-circadian-disruption
#18
REVIEW
Yvan Touitou, Alain Reinberg, David Touitou
Exposure to Artificial Light At Night (ALAN) results in a disruption of the circadian system, which is deleterious to health. In industrialized countries, 75% of the total workforce is estimated to have been involved in shift work and night work. Epidemiologic studies, mainly of nurses, have revealed an association between sustained night work and a 50-100% higher incidence of breast cancer.The potential and multifactorial mechanisms of the effects include the suppression of melatonin secretion by ALAN, sleep deprivation, and circadian disruption...
February 15, 2017: Life Sciences
https://www.readbyqxmd.com/read/28214102/vitreomacular-adhesion-and-the-risk-of-neovascular-age-related-macular-degeneration
#19
Emilia Maggio, Antonio Polito, Massimo Guerriero, Guido Prigione, Barbara Parolini, Grazia Pertile
PURPOSE: To assess the prevalence of vitreomacular adhesion (VMA) in consecutive naïve eyes diagnosed with exudative age-related macular degeneration (AMD) in comparison with eyes with nonexudative AMD and age-matched controls, and to evaluate prospectively the incidence of vitreomacular interface changes over time and their influence on choroidal neovascularization (CNV) development. DESIGN: Retrospective cross-sectional analysis and longitudinal cohort study conducted at Sacrocuore Hospital, Negrar, Verona, Italy...
February 14, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28211882/aflibercept-as-a-second-line-therapy-for-neovascular-age-related-macular-degeneration-in-israel-asli-study
#20
L Tiosano, O Segal, N Mathalone, A Pollack, R Ehrlich, I Klemperer, Y Barak, I Moroz, I Chowers, M Goldstein
PurposeThe purpose of this study is to evaluate an early switch to aflibecept in eyes with neovascular age-related macular degeneration (nvAMD) showing partial or lack of response for initial therapy with bevacizumab.MethodsThe Aflibercept as a Second Line Therapy for Neovascular Age Related Macular Degeneration in Israel (ASLI) was a prospective, multicenter, single-arm clinical trial. Eyes with nvAMD having incomplete response to 3-9 prior bevacizumab injections were recruited. Three monthly intravitreal aflibercept (2 mg) injections were administered, followed by two bi-monthly injections and a final examination at week 28...
February 17, 2017: Eye
keyword
keyword
1762
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"