Jerzy Lasota, Małgorzata Chłopek, Bartosz Wasąg, Artur Kowalik, Jason Christiansen, Jennifer Lamoureux, Alina Kuźniacka, Anna Felisiak-Gołąbek, Yalan Liu, Tiffany Ashley R Reyes, Rishabh Saha, Abbas Agaimy, Kristyna Behenska, Wojciech Biernat, Laura Cattaneo, Giovanni Centonze, Ondrej Daum, Magdalena Daumova, Paweł Domagała, Ireneusz Dziuba, Carol E Geppert, Stanisław Góźdź, Anna Nasierowska-Guttmejer, Agnieszka Hałoń, Arndt Hartmann, Shingo Inaguma, Ewa Iżycka-Świeszewska, Maciej Kaczorowski, Małgorzata Kołos, Janusz Kopczyński, Michal Michal, Massimo Milione, Krzysztof Okoń, Rafał Pęksa, Michał Pyzlak, Janusz Ryś, Piotr Waloszczyk, Jaroslaw Wejman, Markku Miettinen
This study determined the frequency and the clinicopathologic and genetic features of colorectal carcinomas driven by oncogenic fusions of the anaplastic lymphoma kinase gene (ALK). Of the 8150 screened tumors, 12 (0.15%) were immunohistochemically ALK-positive with D5F3 antibody. These cancers harbored CAD-ALK (n=1), DIAPH2-ALK (n=2), EML4-ALK (n=2), LOC101929227-ALK (n=1), SLMAP-ALK (n=1), SPTBN1-ALK (n=4), and STRN-ALK (n=1) fusions, as detected by an RNA-based next-generation sequencing assay. ALK fusion carcinomas were diagnosed mostly in older patients with a 9:3 female predominance (median age: 72 y)...
September 2020: American Journal of Surgical Pathology