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Serrated neoplasm

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https://www.readbyqxmd.com/read/28746986/the-histopathological-classification-diagnosis-and-differential-diagnosis-of-mucinous-appendiceal-neoplasms-appendiceal-adenocarcinomas-and-pseudomyxoma-peritonei
#1
REVIEW
Norman J Carr, Frederic Bibeau, Robert F Bradley, Peggy Dartigues, Roger M Feakins, Kim R Geisinger, Xianyong Gui, Sylvie Isaac, Massimo Milione, Joseph Misdraji, Reetesh K Pai, Manuel Rodriguez-Justo, Leslie H Sobin, Marie-Louise F van Velthuysen, Rhonda K Yantiss
The vermiform appendix is the primary site of several distinctive benign and malignant neoplasms. Some can produce the clinical syndrome of pseudomyxoma peritonei (PMP). A consensus on their terminology was reached by an international panel of pathologists and clinicians working under the auspices of the Peritoneal Surface Oncology Group International (PSOGI) and this review discusses the application of the PSOGI classification to routine reporting. We discuss diagnosis and differential diagnosis together with implications for patient management, covering low-grade appendiceal mucinous neoplasms, high-grade appendiceal mucinous neoplasms, serrated polyps, adenomas, and adenocarcinomas...
July 26, 2017: Histopathology
https://www.readbyqxmd.com/read/28639142/serrated-polyps-of-colon-and-rectum-a-clinicopathologic-review
#2
REVIEW
Bita Geramizadeh, Scott Robertson
BACKGROUND: In the past decade, there have been significant changes in the classification and nomenclature of colorectal polyps. Previously, only two groups of lesions were widely recognized, the adenoma and the hyperplastic polyp. Adenomas were considered the only precursor of colorectal cancer, and hyperplastic polyps were considered innocent with no malignant potential. However, recent discoveries about molecular pathways of colorectal cancers have significantly changed our understanding of these neoplasms...
June 22, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/28507755/ethnic-variations-in-the-occurrence-of-colonic-neoplasms
#3
Amnon Sonnenberg, Kevin O Turner, Robert M Genta
BACKGROUND AND AIMS: With the exception of African Americans and Hispanics, few studies have dealt with the influence of other types of ethnicity on the prevalence of colon polyps and colorectal cancer. The present study was undertaken to compare the ethnic and socioeconomic distributions of colonic neoplasms among different ethnic groups in the United States. METHODS: A total of 813,057 patients, who underwent colonoscopy during 2008-2014, were recruited from an electronic database of histopathology reports (Miraca Life Sciences) for a cross-sectional study...
April 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28172592/p133-a-novel-candidate-pathway-for-development-of-neoplasms-with-serrated-morphology-in-patients-with-ulcerative-colitis
#4
M Nishio, W Shibata, Y Ajioka, K Hirasawa, W Ueda, K Okawa, H Otake, T Ogashiwa, A Takase, S Chiba, Y Inayama, H Kimura, R Kunisaki, S Maeda
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28164369/gnas-mutations-are-present-in-colorectal-traditional-serrated-adenomas-serrated-tubulovillous-adenomas-and-serrated-adenocarcinomas-with-adverse-prognostic-features
#5
Cheng Liu, Diane M McKeone, Neal I Walker, Mark L Bettington, Barbara A Leggett, Vicki L J Whitehall
AIMS: Activating mutations in GNAS are important in the development of a range of neoplasms, including a small proportion of conventional adenomas and colorectal carcinomas (CRCs). However, their contribution to serrated pathway neoplasia is unclear, as mutations have only been examined in small series of sessile serrated adenomas (SSAs) and traditional serrated adenomas (TSAs), and not in serrated tubulovillous adenomas (sTVAs). The aim of this study was to investigate the frequency and significance of GNAS mutations in colorectal adenomas and CRCs...
February 6, 2017: Histopathology
https://www.readbyqxmd.com/read/27926665/clinicopathological-analysis-and-risk-factors-of-advanced-colorectal-neoplasms-incidentally-detected-by-18f-fdg-pet-ct
#6
Seung Min Chung, Kyeong Ok Kim, Ihn Ho Cho, Tae Nyeun Kim
BACKGROUND: As the clinical use of fluorine-18-fluorodeoxyglucose PET-computed tomography (F-FDG PET-CT) has increased, the incidental finding of F-FDG uptake with subsequent diagnosis of advanced neoplasm at colorectum has increased. The aim of this study is to analyze the characteristics and risk factors of advanced colorectal neoplasm incidentally detected by F-FDG PET-CT. PATIENTS AND METHODS: Patients who underwent colonoscopy because of an incidental finding of F-FDG uptake at the colorectum from January 2006 to January 2015 at Yeungnam University Hospital were reviewed retrospectively...
April 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27906163/expression-of-annexin-a10-in-serrated-polyps-predicts-the-development-of-metachronous-serrated-polyps
#7
Carole Macaron, Rocio Lopez, Rish K Pai, Carol A Burke
OBJECTIVES: The ability to differentiate histological characteristics between serrated polyps (SPs) and make a pathological diagnosis of a sessile serrated polyp (SSP) is highly variable. Recent studies have shown that immunohistochemical (IHC) expression of Annexin A10 (ANXA10) is a marker of a SSP. However, the clinical utility of ANXA10 expression in patients with SPs is unknown. The objective of this study was to evaluate the utility of ANXA10 expression in SPs in predicting the development of subsequent polyps at follow-up colonoscopy...
December 1, 2016: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/27884518/multitarget-stool-dna-test-clinical-performance-and-impact%C3%A2-on%C3%A2-yield-and-quality-of-colonoscopy-for-colorectal-cancer-screening
#8
David H Johnson, John B Kisiel, Kelli N Burger, Douglas W Mahoney, Mary E Devens, David A Ahlquist, Seth Sweetser
BACKGROUND AND AIMS: Multitarget stool DNA (MT-sDNA) testing is now approved by the U.S. Food and Drug Administration for average-risk colorectal cancer screening. Trials leading to its approval used blinded colonoscopy as the reference standard. In the postapproval screen setting, the clinical performance and impact of MT-sDNA testing on unblinded colonoscopy has not been described. We measured the impact that knowledge of a positive MT-sDNA test result has on colonoscopy yield and quality...
March 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27639804/lifestyle-risk-factors-for-serrated-colorectal-polyps-a%C3%A2-systematic-review-and-meta-analysis
#9
REVIEW
Lesley Bailie, Maurice B Loughrey, Helen G Coleman
BACKGROUND & AIMS: Certain subsets of colorectal serrated polyps (SP) have malignant potential. We performed a systematic review and meta-analysis to investigate the association between modifiable lifestyle factors and risk for SPs. METHODS: We conducted a systematic search of Medline, Embase, and Web of Science for observational or interventional studies that contained the terms risk or risk factor, and serrated or hyperplastic, and polyps or adenomas, and colorectal (or synonymous terms), published by March 2016...
January 2017: Gastroenterology
https://www.readbyqxmd.com/read/27639328/patients-with-nonpolypoid-flat-and-depressed-colorectal-neoplasms-at-increased-risk-for-advanced-neoplasias-compared-with-patients-with-polypoid-neoplasms
#10
Sarah K McGill, Roy Soetikno, Robert V Rouse, Hobart Lai, Tonya Kaltenbach
BACKGROUND & AIMS: Nonpolypoid colorectal neoplasms (NP-CRNs) are more likely to contain high-grade dysplasia or early-stage cancer than polypoid neoplasms. We aimed to determine the long-term outcomes of patients with at least 1 NP-CRN. METHODS: We performed a longitudinal cohort study of 4454 patients at a Veterans' Affairs hospital who underwent colonoscopy from 2000 through 2005; 341 were found to have 1 or more NP-CRNs and were matched (3:1) with patients found to have 1 or more polypoid neoplasms (controls, n = 1025)...
September 14, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27499922/the-molecular-characteristics-of-colonic-neoplasms-in-serrated-polyposis-a-systematic-review-and-meta-analysis
#11
REVIEW
Emily Y He, Lucy Wyld, Mathew A Sloane, Karen Canfell, Robyn L Ward
Serrated polyposis is a rare disorder characterised by the presence of multiple serrated polyps in the large intestine, and an increased personal and familial risk of colorectal cancer. Knowledge of the molecular characteristics of colonic lesions which develop in this syndrome is fragmented, making it difficult to understand the underlying genetic basis of this condition. We conducted a systematic review and meta-analysis of all studies which evaluated the molecular characteristics of colorectal neoplasms found in individuals with serrated polyposis...
July 2016: Journal of Pathology. Clinical Research
https://www.readbyqxmd.com/read/27498176/fecal-immunochemical-test-detects-sessile-serrated-adenomas%C3%A2-and-polyps-with-a-low-level-of-sensitivity
#12
Li-Chun Chang, Chia-Tung Shun, Weng-Feng Hsu, Chia-Hong Tu, Pei-Yu Tsai, Been-Ren Lin, Jin-Tung Liang, Ming-Shiang Wu, Han-Mo Chiu
BACKGROUND & AIMS: The serrated pathway is a distinct pathway of colorectal carcinogenesis that has been implicated in development of a substantial proportion of interval colorectal cancers. The fecal immunochemical test (FIT) detects early neoplasms with a higher level of sensitivity than the guaiac test. We investigated the sensitivity of the FIT in detection of sessile serrated adenomas/polyps (SSA/Ps). METHODS: We performed a prospective study of 6198 asymptomatic subjects (mean age, 59...
August 4, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27466549/synchronous-quadruple-primary-neoplasms-colon-adenocarcinoma-collision-tumor-of-neuroendocrine-tumor-and-schwann-cell-hamartoma-and-sessile-serrated-adenoma-of-the-appendix
#13
Marshall W Meeks, Shane Grace, Yongxin Chen, James Petterchak, Edward Bolesta, Yihua Zhou, Jin-Ping Lai
Quadruple synchronous primary neoplasms are very rare with only three cases reported in the English-speaking literature to date. Collision tumors are also rare entities, especially of the appendix. We herein report a case of synchronous quadruple primary neoplasm in a 95-year-old female. She was diagnosed with colon adenocarcinoma, sessile serrated adenoma of the appendix and a collision tumor composed of a well-differentiated neuroendocrine tumor and Schwann cell hamartoma. Histological examination and immunohistochemistry supported these four lesions as separate entities...
August 2016: Anticancer Research
https://www.readbyqxmd.com/read/27358228/prediction-of-the-risk-of-a-metachronous-advanced-colorectal-neoplasm-using-a-novel-scoring-system
#14
Ji Young Lee, Hye Won Park, Min-Ju Kim, Jong-Soo Lee, Ho-Su Lee, Hye-Sook Chang, Jaewon Choe, Sung Wook Hwang, Dong-Hoon Yang, Seung-Jae Myung, Suk-Kyun Yang, Jeong-Sik Byeon
BACKGROUND AND AIM: This study aimed to develop and validate a risk score model to estimate the probability of a metachronous advanced colorectal neoplasm (ACRN) at surveillance colonoscopy. METHODS: A retrospective analysis of a prospectively obtained database of 11,042 asymptomatic subjects who underwent surveillance colonoscopy after a screening colonoscopy was conducted. Subjects were randomly divided into derivation (n = 7730) and validation sets (n = 3312)...
October 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/27305845/rnf43-is-an-early-and-specific-mutated-gene-in-the-serrated-pathway-with-increased-frequency-in-traditional-serrated-adenoma-and-its-associated-malignancy
#15
Jia-Huei Tsai, Jau-Yu Liau, Chang-Tsu Yuan, Yu-Lin Lin, Li-Hui Tseng, Mei-Ling Cheng, Yung-Ming Jeng
RNF43 is an E3 ligase that suppresses the Wnt/β-catenin signaling pathway and is frequently mutated in microsatellite-unstable colorectal carcinoma. To investigate the pathogenetic role of RNF43 in the serrated pathway, we conducted mutation analysis of RNF43 in several types of colorectal neoplasms. RNF43 mutation was found in 2 of 20 (10%) sessile serrated adenomas, 10 of 36 (28%) traditional serrated adenomas, 7 of 37 (19%) traditional serrated adenomas with cytologic dysplasia, and 9 of 31 (29%) BRAF-mutated/microsatellite-stable colorectal carcinomas; however, no mutation was found in 30 tubulovillous/villous adenomas...
October 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27296001/-%C3%B0-xpression-of-claudin-1-3-and-4-in-colorectal-cancer-and-polyps
#16
N А Nefedova, О А Kharlova, P G Malkov
UNLABELLED: Claudins are a family of transmembrane tight junctions proteins. It is proven that claudins undergo structural and functional alteration in malignant cells. However, very few researches are pursued on this topic, the data provided by different researchers are controversial. The aim of this study was to evaluate expression of tight junction proteins in cancer and benign polyps of the colon and rectum. MATERIAL AND METHODS: Specimens of 32 colorectal adenocarcinomas and biopsy specimens of 86 polypoid lesions of the colon and rectum were selected from diagnostic material...
May 2016: Arkhiv Patologii
https://www.readbyqxmd.com/read/27125587/role-of-fusobacteria-in-the-serrated-pathway-of-colorectal-carcinogenesis
#17
Chan Hyuk Park, Dong Soo Han, Young-Ha Oh, A-Reum Lee, Yu-Ra Lee, Chang Soo Eun
Fusobacteria are associated with colorectal cancer (CRC) and are amplified during colorectal carcinogenesis. Compared to the adenoma-carcinoma sequence of carcinogenesis, serrated neoplasm has distinct clinical features and a different molecular background. We aimed to compare the gut microbiome between tubular adenoma (TA) and sessile serrated adenoma/polyp (SSA/P). Patients with TA, SSA/P, or CRC were recruited. Three pieces of colorectal mucosal tissue were obtained from each patient by endoscopic biopsy...
April 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27104828/dna-methylation-and-mutation-of-small-colonic-neoplasms-in-ulcerative-colitis-and-crohn-s-colitis-implications-for-surveillance
#18
David H Johnson, William R Taylor, Mohammed M Aboelsoud, Patrick H Foote, Tracy C Yab, Xiaoming Cao, Thomas C Smyrk, Edward V Loftus, Douglas W Mahoney, David A Ahlquist, John B Kisiel
BACKGROUND: Stool DNA testing in patients with inflammatory bowel disease (IBD) may detect colorectal cancer and advanced precancers with high sensitivity; less is known about the presence of DNA markers in small IBD lesions, their association with metachronous neoplasia, or contribution to stool test positivity. METHODS: At a single center in 2 blinded phases, we assayed methylated bone morphogenic protein 3, methylated N-Myc downstream-regulated gene 4, and mutant KRAS in DNA extracted from paraffin-embedded benign lesions, and matched control tissues of patients with IBD, who were followed for subsequent colorectal dysplasia...
July 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27101589/outcome-of-appendicectomies-at-surgery-for-mucinous-ovarian-neoplasms-report-from-a-uk-center-and-review-of-literature
#19
Debjani Mukhopadhyay, Ramzi Rajab, Marielle Nobbenhuis, James Dilley, Owen Heath, Jayson Wang, Thomas E J Ind, Desmond P J Barton
OBJECTIVE: This study aimed to determine the frequency of malignant pathology in a macroscopically normal appendix during surgery for a borderline or malignant mucinous ovarian tumor (MOT). METHODS: Women with borderline and malignant MOT were identified from the pathology database from 2000 to 2014. Women who had a benign MOT and had an appendicectomy were excluded from the study. Data were collected from the electronic patient record and case notes. RESULTS: Of 310 women identified with MOT, 203 patients with benign MOT were excluded...
July 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27087961/type-1-serrated-polyposis-represents-a-predominantly-female-disease-with-a-high-prevalence-of-dysplastic-serrated-adenomas-without-germline-mutation-in-mutyh-apc-and-pten-genes
#20
Marco Petronio, Stephane Pinson, Thomas Walter, Marie-Odile Joly, Valerie Hervieu, Julien Forestier, Jean-Christophe Saurin
AIM: The aim of this article is to clarify the epidemiologic, clinical, endoscopic, biological and genetic characteristics of type 1 serrated polyposis patients. PATIENTS AND METHODS: Consecutive patients responding to the WHO definition of type 1 serrated polyposis in one reference center for polyposis patients accepted genetic counseling. Detailed data on previous endoscopies, histology, and life habits were recorded, after informed consent, germline analysis of MUTYH, APC, and PTEN germline mutations...
April 2016: United European Gastroenterology Journal
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