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Serrated neoplasm

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https://www.readbyqxmd.com/read/27906163/expression-of-annexin-a10-in-serrated-polyps-predicts-the-development-of-metachronous-serrated-polyps
#1
Carole Macaron, Rocio Lopez, Rish K Pai, Carol A Burke
OBJECTIVES: The ability to differentiate histological characteristics between serrated polyps (SPs) and make a pathological diagnosis of a sessile serrated polyp (SSP) is highly variable. Recent studies have shown that immunohistochemical (IHC) expression of Annexin A10 (ANXA10) is a marker of a SSP. However, the clinical utility of ANXA10 expression in patients with SPs is unknown. The objective of this study was to evaluate the utility of ANXA10 expression in SPs in predicting the development of subsequent polyps at follow-up colonoscopy...
December 1, 2016: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/27884518/multi-target-stool-dna-test-clinical-performance-and-impact-on-yield-and-quality-of-colonoscopy-for-colorectal-cancer-screening
#2
David H Johnson, John B Kisiel, Kelli N Burger, Douglas W Mahoney, Mary E Devens, David A Ahlquist, Seth Sweetser
BACKGROUND & AIMS: Multi-target stool DNA testing (MT-sDNA) is now FDA-approved for average-risk CRC screening. Trials leading to its approval used blinded colonoscopy as the reference standard. In the post-approval screen setting, the clinical performance and impact of MT-sDNA on unblinded colonoscopy has not been described. We measured the impact that knowledge of a positive MT-sDNA test result has on colonoscopy yield and quality. METHODS: The unblinded group comprised all patients with positive MT-sDNA results on screening from 9/1/14-9/30/15 at a single tertiary center...
November 21, 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27639804/lifestyle-risk-factors-for-serrated-colorectal-polyps-a%C3%A2-systematic-review-and-meta-analysis
#3
Lesley Bailie, Maurice B Loughrey, Helen G Coleman
BACKGROUND & AIMS: Certain subsets of colorectal serrated polyps (SP) have malignant potential. We performed a systematic review and meta-analysis to investigate the association between modifiable lifestyle factors and risk for SPs. METHODS: We conducted a systematic search of Medline, Embase, and Web of Science for observational or interventional studies that contained the terms risk or risk factor, and serrated or hyperplastic, and polyps or adenomas, and colorectal (or synonymous terms), published by March 2016...
September 14, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27639328/patients-with-nonpolypoid-flat-and-depressed-colorectal-neoplasms-at-increased-risk-for-advanced-neoplasias-compared-with-patients-with-polypoid-neoplasms
#4
Sarah K McGill, Roy Soetikno, Robert V Rouse, Hobart Lai, Tonya Kaltenbach
BACKGROUND & AIMS: Nonpolypoid colorectal neoplasms (NP-CRNs) are more likely to contain high-grade dysplasia or early-stage cancer than polypoid neoplasms. We aimed to determine the long-term outcomes of patients with at least 1 NP-CRN. METHODS: We performed a longitudinal cohort study of 4454 patients at a Veterans' Affairs hospital who underwent colonoscopy from 2000 through 2005; 341 were found to have 1 or more NP-CRNs and were matched (3:1) with patients found to have 1 or more polypoid neoplasms (controls, n = 1025)...
September 14, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27499922/the-molecular-characteristics-of-colonic-neoplasms-in-serrated-polyposis-a-systematic-review-and-meta-analysis
#5
REVIEW
Emily Y He, Lucy Wyld, Mathew A Sloane, Karen Canfell, Robyn L Ward
Serrated polyposis is a rare disorder characterised by the presence of multiple serrated polyps in the large intestine, and an increased personal and familial risk of colorectal cancer. Knowledge of the molecular characteristics of colonic lesions which develop in this syndrome is fragmented, making it difficult to understand the underlying genetic basis of this condition. We conducted a systematic review and meta-analysis of all studies which evaluated the molecular characteristics of colorectal neoplasms found in individuals with serrated polyposis...
July 2016: Journal of Pathology. Clinical Research
https://www.readbyqxmd.com/read/27498176/fecal-immunochemical-test-detects-sessile-serrated-adenomas%C3%A2-and-polyps-with-a-low-level-of-sensitivity
#6
Li-Chun Chang, Chia-Tung Shun, Weng-Feng Hsu, Chia-Hong Tu, Pei-Yu Tsai, Been-Ren Lin, Jin-Tung Liang, Ming-Shiang Wu, Han-Mo Chiu
BACKGROUND & AIMS: The serrated pathway is a distinct pathway of colorectal carcinogenesis that has been implicated in development of a substantial proportion of interval colorectal cancers. The fecal immunochemical test (FIT) detects early neoplasms with a higher level of sensitivity than the guaiac test. We investigated the sensitivity of the FIT in detection of sessile serrated adenomas/polyps (SSA/Ps). METHODS: We performed a prospective study of 6198 asymptomatic subjects (mean age, 59...
August 4, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27466549/synchronous-quadruple-primary-neoplasms-colon-adenocarcinoma-collision-tumor-of-neuroendocrine-tumor-and-schwann-cell-hamartoma-and-sessile-serrated-adenoma-of-the-appendix
#7
Marshall W Meeks, Shane Grace, Yongxin Chen, James Petterchak, Edward Bolesta, Yihua Zhou, Jin-Ping Lai
Quadruple synchronous primary neoplasms are very rare with only three cases reported in the English-speaking literature to date. Collision tumors are also rare entities, especially of the appendix. We herein report a case of synchronous quadruple primary neoplasm in a 95-year-old female. She was diagnosed with colon adenocarcinoma, sessile serrated adenoma of the appendix and a collision tumor composed of a well-differentiated neuroendocrine tumor and Schwann cell hamartoma. Histological examination and immunohistochemistry supported these four lesions as separate entities...
August 2016: Anticancer Research
https://www.readbyqxmd.com/read/27358228/prediction-of-the-risk-of-a-metachronous-advanced-colorectal-neoplasm-using-a-novel-scoring-system
#8
Ji Young Lee, Hye Won Park, Min-Ju Kim, Jong-Soo Lee, Ho-Su Lee, Hye-Sook Chang, Jaewon Choe, Sung Wook Hwang, Dong-Hoon Yang, Seung-Jae Myung, Suk-Kyun Yang, Jeong-Sik Byeon
BACKGROUND AND AIM: This study aimed to develop and validate a risk score model to estimate the probability of a metachronous advanced colorectal neoplasm (ACRN) at surveillance colonoscopy. METHODS: A retrospective analysis of a prospectively obtained database of 11,042 asymptomatic subjects who underwent surveillance colonoscopy after a screening colonoscopy was conducted. Subjects were randomly divided into derivation (n = 7730) and validation sets (n = 3312)...
October 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/27305845/rnf43-is-an-early-and-specific-mutated-gene-in-the-serrated-pathway-with-increased-frequency-in-traditional-serrated-adenoma-and-its-associated-malignancy
#9
Jia-Huei Tsai, Jau-Yu Liau, Chang-Tsu Yuan, Yu-Lin Lin, Li-Hui Tseng, Mei-Ling Cheng, Yung-Ming Jeng
RNF43 is an E3 ligase that suppresses the Wnt/β-catenin signaling pathway and is frequently mutated in microsatellite-unstable colorectal carcinoma. To investigate the pathogenetic role of RNF43 in the serrated pathway, we conducted mutation analysis of RNF43 in several types of colorectal neoplasms. RNF43 mutation was found in 2 of 20 (10%) sessile serrated adenomas, 10 of 36 (28%) traditional serrated adenomas, 7 of 37 (19%) traditional serrated adenomas with cytologic dysplasia, and 9 of 31 (29%) BRAF-mutated/microsatellite-stable colorectal carcinomas; however, no mutation was found in 30 tubulovillous/villous adenomas...
October 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27296001/-%C3%B0-xpression-of-claudin-1-3-and-4-in-colorectal-cancer-and-polyps
#10
N A Nefedova, O A Kharlova, P G Mal'kov
UNLABELLED: Claudins are a family of transmembrane tight junctions proteins. It is proven that claudins undergo structural and functional alteration in malignant cells. However, very few researches are pursued on this topic, the data provided by different researchers are controversial. The aim of this study was to evaluate expression of tight junction proteins in cancer and benign polyps of the colon and rectum. MATERIAL AND METHODS: Specimens of 32 colorectal adenocarcinomas and biopsy specimens of 86 polypoid lesions of the colon and rectum were selected from diagnostic material...
May 2016: Arkhiv Patologii
https://www.readbyqxmd.com/read/27125587/role-of-fusobacteria-in-the-serrated-pathway-of-colorectal-carcinogenesis
#11
Chan Hyuk Park, Dong Soo Han, Young-Ha Oh, A-Reum Lee, Yu-Ra Lee, Chang Soo Eun
Fusobacteria are associated with colorectal cancer (CRC) and are amplified during colorectal carcinogenesis. Compared to the adenoma-carcinoma sequence of carcinogenesis, serrated neoplasm has distinct clinical features and a different molecular background. We aimed to compare the gut microbiome between tubular adenoma (TA) and sessile serrated adenoma/polyp (SSA/P). Patients with TA, SSA/P, or CRC were recruited. Three pieces of colorectal mucosal tissue were obtained from each patient by endoscopic biopsy...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27104828/dna-methylation-and-mutation-of-small-colonic-neoplasms-in-ulcerative-colitis-and-crohn-s-colitis-implications-for-surveillance
#12
David H Johnson, William R Taylor, Mohammed M Aboelsoud, Patrick H Foote, Tracy C Yab, Xiaoming Cao, Thomas C Smyrk, Edward V Loftus, Douglas W Mahoney, David A Ahlquist, John B Kisiel
BACKGROUND: Stool DNA testing in patients with inflammatory bowel disease (IBD) may detect colorectal cancer and advanced precancers with high sensitivity; less is known about the presence of DNA markers in small IBD lesions, their association with metachronous neoplasia, or contribution to stool test positivity. METHODS: At a single center in 2 blinded phases, we assayed methylated bone morphogenic protein 3, methylated N-Myc downstream-regulated gene 4, and mutant KRAS in DNA extracted from paraffin-embedded benign lesions, and matched control tissues of patients with IBD, who were followed for subsequent colorectal dysplasia...
July 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27101589/outcome-of-appendicectomies-at-surgery-for-mucinous-ovarian-neoplasms-report-from-a-uk-center-and-review-of-literature
#13
Debjani Mukhopadhyay, Ramzi Rajab, Marielle Nobbenhuis, James Dilley, Owen Heath, Jayson Wang, Thomas E J Ind, Desmond P J Barton
OBJECTIVE: This study aimed to determine the frequency of malignant pathology in a macroscopically normal appendix during surgery for a borderline or malignant mucinous ovarian tumor (MOT). METHODS: Women with borderline and malignant MOT were identified from the pathology database from 2000 to 2014. Women who had a benign MOT and had an appendicectomy were excluded from the study. Data were collected from the electronic patient record and case notes. RESULTS: Of 310 women identified with MOT, 203 patients with benign MOT were excluded...
July 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27087961/type-1-serrated-polyposis-represents-a-predominantly-female-disease-with-a-high-prevalence-of-dysplastic-serrated-adenomas-without-germline-mutation-in-mutyh-apc-and-pten-genes
#14
Marco Petronio, Stephane Pinson, Thomas Walter, Marie-Odile Joly, Valerie Hervieu, Julien Forestier, Jean-Christophe Saurin
AIM: The aim of this article is to clarify the epidemiologic, clinical, endoscopic, biological and genetic characteristics of type 1 serrated polyposis patients. PATIENTS AND METHODS: Consecutive patients responding to the WHO definition of type 1 serrated polyposis in one reference center for polyposis patients accepted genetic counseling. Detailed data on previous endoscopies, histology, and life habits were recorded, after informed consent, germline analysis of MUTYH, APC, and PTEN germline mutations...
April 2016: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/26688706/multiple-primary-colorectal-cancer-individual-or-familial-predisposition
#15
REVIEW
José A Pajares, José Perea
Colorectal carcinoma (CRC) is one of the most frequent cancers. Along the surface of the large bowel, several foci of CRC may appear simultaneously or over the time. The development of at least two different tumours has been defined as multiple primary CRC (MPCRC): When more than one tumour is diagnosed at the same time, it is known as synchronous CRC (SCRC), while when a second neoplasm is diagnosed some time after the resection and/or diagnosis of the first lesion, it is called metachronous CRC (MCRC). Multiple issues can promote the development of MPCRC, ranging from different personal factors, such as environmental exposure, to familial predisposition due to hereditary factors...
December 15, 2015: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/26520415/stool-dna-testing-for-screening-detection-of-colorectal-neoplasia-in-alaska-native-people
#16
Diana G Redwood, Elvin D Asay, Ian D Blake, Pamela E Sacco, Claudia M Christensen, Frank D Sacco, James J Tiesinga, Mary E Devens, Steven R Alberts, Douglas W Mahoney, Tracy C Yab, Patrick H Foote, Thomas C Smyrk, Ellen M Provost, David A Ahlquist
OBJECTIVE: To assess the accuracy of a multitarget stool DNA test (MT-sDNA) compared with fecal immunochemical testing for hemoglobin (FIT) for detection of screening-relevant colorectal neoplasia (SRN) in Alaska Native people, who have among the world's highest rates of colorectal cancer (CRC) and limited access to conventional screening approaches. PATIENTS AND METHODS: We performed a prospective, cross-sectional study of asymptomatic Alaska Native adults aged 40-85 years and older undergoing screening or surveillance colonoscopy between February 6, 2012, and August 7, 2014...
January 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/26492181/a-consensus-for-classification-and-pathologic-reporting-of-pseudomyxoma-peritonei-and-associated-appendiceal-neoplasia-the-results-of-the-peritoneal-surface-oncology-group-international-psogi-modified-delphi-process
#17
Norman J Carr, Thomas D Cecil, Faheez Mohamed, Leslie H Sobin, Paul H Sugarbaker, Santiago González-Moreno, Panos Taflampas, Sara Chapman, Brendan J Moran
Pseudomyxoma peritonei (PMP) is a complex disease with unique biological behavior that usually arises from appendiceal mucinous neoplasia. The classification of PMP and its primary appendiceal neoplasia is contentious, and an international modified Delphi consensus process was instigated to address terminology and definitions. A classification of mucinous appendiceal neoplasia was developed, and it was agreed that "mucinous adenocarcinoma" should be reserved for lesions with infiltrative invasion. The term "low-grade appendiceal mucinous neoplasm" was supported and it was agreed that "cystadenoma" should no longer be recommended...
January 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/26350188/absence-of-gnas-mutation-in-colorectal-carcinogenesis
#18
Hyunsu Lee, Boo-Mi La, IlSeon Hwang, Yu-Na Kang, In-Jang Choi, Jae-Ho Lee
AIMS AND BACKGROUND: The incidence rate of colorectal cancer (CRC) increases every year in Korean populations. However, association between the GNAS mutation and colorectal precancerous lesions has not been studied in in Korean populations. To contribute to better understanding of colorectal carcinogenesis, we analyzed GNAS mutation in 100 cancerous and 96 precancerous colorectal lesions. METHODS: The records of colonoscopic polypectomy performed at Dongsan Medical Center between 1999 and 2003 were reviewed retrospectively...
August 26, 2015: Tumori
https://www.readbyqxmd.com/read/26297256/clinical-pathologic-and-outcome-study-of-hyperplastic-and-sessile-serrated-polyps-in-inflammatory-bowel-disease
#19
Jeanne Shen, Joanna A Gibson, Stephanie Schulte, Hema Khurana, Francis A Farraye, Jonathan Levine, Robert Burakoff, Sandra Cerda, Taha Qazi, Matthew Hamilton, Amitabh Srivastava, Robert D Odze
There is evidence that some cancers in patients with inflammatory bowel disease (IBD) develop via the serrated pathway of carcinogenesis. This study examined the clinicopathological features and outcome of 115 IBD patients (65 with ulcerative colitis, 50 with Crohn disease), all with at least 1 serrated polyp at endoscopy or colon resection, including the presence of synchronous and metachronous conventional neoplastic lesions (dysplasia or adenocarcinoma), over an average follow-up period of 56.4 months. Conventional neoplasia was categorized as flat dysplasia (low or high grade), sporadic adenoma, adenoma-like dysplasia-associated lesion or mass, or adenocarcinoma...
October 2015: Human Pathology
https://www.readbyqxmd.com/read/26259154/derivation-and-validation-of-a-scoring-system-to-stratify-risk-for-advanced-colorectal-neoplasia-in-asymptomatic-adults-a-cross-sectional-study
#20
Thomas F Imperiale, Patrick O Monahan, Timothy E Stump, Elizabeth A Glowinski, David F Ransohoff
BACKGROUND: Several methods are recommended equally strongly for colorectal cancer screening in average-risk persons. Risk stratification would enable tailoring of screening within this group, with less invasive tests (sigmoidoscopy or occult blood tests) for lower-risk persons and colonoscopy for higher-risk persons. OBJECTIVE: To create a risk index for advanced neoplasia (colorectal cancer and adenomas or serrated polyps ≥1.0 cm, villous histology, or high-grade dysplasia) anywhere in the colorectum, using the most common risk factors for colorectal neoplasia...
September 1, 2015: Annals of Internal Medicine
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