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Sessile serrated polyp

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https://www.readbyqxmd.com/read/28325827/sessile-serrated-polyps-and-colon-cancer-prevention
#1
Shahrooz Rashtak, Rafaela Rego, Seth R Sweetser, Frank A Sinicrope
Evidence suggests that up to one fifth of colorectal carcinomas (CRC) develop from serrated polyps, named for their pattern of colonic crypts, and include the sessile serrated adenoma/polyp (SSA/P) that has malignant potential. SSA/Ps are typically located in the proximal colon and have molecular features of hypermethylation of CpG islands in gene promoters and activating point mutations (V600E) in the BRAF oncogene. Both of these features are seen in sporadic CRCs with microsatellite instability (MSI) which is potentially consistent with an origin of these cancers from precursor SSA/Ps...
March 21, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28320200/clinical-and-biological-features-of-interval-colorectal-cancer
#2
Yu Mi Lee, Kyu Chan Huh
Interval colorectal cancer (I-CRC) is defined as a CRC diagnosed within 60 months after a negative colonoscopy, taking into account that 5 years is the "mean sojourn time." It is important to prevent the development of interval cancer. The development of interval colon cancer is associated with female sex, old age, family history of CRC, comorbidities, diverticulosis, and the skill of the endoscopist. During carcinogenesis, sessile serrated adenomas/polyps (SSA/Ps) share many genomic and colonic site characteristics with I-CRCs...
March 21, 2017: Clinical Endoscopy
https://www.readbyqxmd.com/read/28315031/feasibility-of-large-scale-identification-of-sessile-serrated-polyp-patients-using-electronic-records-a-utah-study
#3
Kajsa Affolter, Keith Gligorich, Niloy Jewel Samadder, Wade S Samowitz, Karen Curtin
BACKGROUND/AIMS: The serrated pathway accounts for 15-25% of sporadic colorectal cancer (CRC). In our study, we sought to accurately characterize sessile serrated polyps (SSP) in a population by electronically interrogating colonoscopy patients' endoscopy and pathology reports using a rules-based text search of pre-defined SSP-related terms. To this aim, we compared a sample of putative SSP and hyperplastic polyps (HP) using our algorithm to a determination of SSP or HP by pathologist and molecular examination to determine the feasibility of large-scale identification of SSP in electronic medical records...
March 17, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28302537/mcm2-expression-in-serrated-polyps-demonstrates-aberrant-cellular-proliferation
#4
Danielle Fortuna, Bruce Boman, Raymond O'Neil, Juan Palazzo
In normal colonic epithelium, the proliferative zone is limited to the lower half of the colonic crypt. Evaluating the changes in the colonic epithelial proliferation can be useful in understanding pathophysiology of various diseases. Our aim was to investigate the proliferative compartment of serrated polyps (SPs) using MCM2, a protein involved in DNA replication, and assess for changes along the SP spectrum. Immunohistochemistry was performed on serrated polyps (16 microvesicular-type hyperplastic polyps (HP), 58 sessile serrated adenomas (SSA), seven SSAs with dysplasia) and six sections of normal colon using anti-MCM2 antibody...
March 13, 2017: Human Pathology
https://www.readbyqxmd.com/read/28295004/-serrated-adenomas-of-the-colon-clinical-morphological-and-molecular-genetic-characteristics
#5
L M Mikhaleva, R A Komleva, A E Biryukov, N K Shakhpazyan
AIM: to investigate the clinical, morphological, and molecular genetic characteristics of serrated adenomas of the colon. MATERIAL AND METHODS: The study included 82 colon adenomas from 63 patients aged 29 to 81 years, who underwent colonoscopy with biopsy or polypectomy. The mean age of men was 63.3 years; that of women was 56.8 years. Comprehensive clinical, morphological, immunohistochemical, and molecular genetic examinations were made. RESULTS: The histological examination showed that sessile serrated adenomas (SSA) of the colon were most common (46...
2017: Arkhiv Patologii
https://www.readbyqxmd.com/read/28279681/lipoma-of-the-colon-with-a-sessile-serrated-adenoma-polyp-and-adenocarcinoma
#6
Stijn J B Van Weyenberg, Danny Goudkade
No abstract text is available yet for this article.
February 24, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28277895/serrated-polyps-a-concealed-but-prevalent-precursor-of-colorectal-cancer
#7
Henrik Thorlacius, Yoji Takeuchi, Takashi Kanesaka, Otto Ljungberg, Noriya Uedo, Ervin Toth
Serrated polyps have long been considered to lack malignant potential but accumulating data suggest that these lesions may cause up to one-third of all sporadic colorectal cancer. Serrated polyps are classified into three subtypes, including sessile serrated adenomas/polyps (SSA/Ps), traditional serrated adenomas (TSAs), and hyperplastic polyps (HPs). SSA/P and TSA harbour malignant potential but TSA represents only 1-2%, wheras SSA/P constitute up to 20% of all serrated lesions. HPs are most common (80%) of all serrated polyps but are considered to have a low potential of developing colorectal cancer...
March 9, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28267853/sessile-serrated-polyps-and-colorectal-cancer-reply
#8
LETTER
David Lieberman
No abstract text is available yet for this article.
March 7, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28267850/sessile-serrated-polyps-and-colorectal-cancer
#9
LETTER
Seth D Crockett
No abstract text is available yet for this article.
March 7, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28260946/the-clinical-impact-of-serrated-colorectal-polyps
#10
REVIEW
Brendon M O'Connell, Seth D Crockett
Serrated polyps (SPs) of the colorectum pose a novel challenge to practicing gastroenterologists. Previously thought benign and unimportant, there is now compelling evidence that SPs are responsible for a significant percentage of incident colorectal cancer worldwide. In contrast to conventional adenomas, which tend to be slow growing and polypoid, SPs have unique features that undermine current screening and surveillance practices. For example, sessile serrated polyps (SSPs) are flat, predominately right-sided, and thought to have the potential for rapid growth...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/28257790/the-diagnostic-performance-of-jnet-classification-for-differentiation-among-noninvasive-superficially-invasive-and-deeply-invasive-colorectal-neoplasia
#11
Kyoku Sumimoto, Shinji Tanaka, Kenjiro Shigita, Nana Hayashi, Daiki Hirano, Yuzuru Tamaru, Yuki Ninomiya, Shiro Oka, Koji Arihiro, Fumio Shimamoto, Masaharu Yoshihara, Kazuaki Chayama
BACKGROUNDS AND AIMS: The Japan NBI Expert Team (JNET) classification is the first universal narrow-band imaging (NBI) magnifying endoscopic classification of colorectal tumors. Considering each type in this classification, the diagnostic ability of Type 2B is the weakest. Generally, clinical behavior is thought to be different in each gross type of colorectal tumor. We evaluated the differences in the diagnostic performance of JNET classification for each gross type (polypoid and superficial) and examined whether the diagnostic performance of Type 2B could improve by subtyping...
February 28, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28257124/hyper-methylated-loci-persisting-from-sessile-serrated-polyps-to-serrated-cancers
#12
Angeline S Andrew, John A Baron, Lynn F Butterly, Arief A Suriawinata, Gregory J Tsongalis, Christina M Robinson, Christopher I Amos
Although serrated polyps were historically considered to pose little risk, it is now understood that progression down the serrated pathway could account for as many as 15%-35% of colorectal cancers. The sessile serrated adenoma/polyp (SSA/P) is the most prevalent pre-invasive serrated lesion. Our objective was to identify the CpG loci that are persistently hyper-methylated during serrated carcinogenesis, from the early SSA/P lesion through the later cancer phases of neoplasia development. We queried the loci hyper-methylated in serrated cancers within our rightsided SSA/Ps from the New Hampshire Colonoscopy Registry, using the Illumina Infinium Human Methylation 450 k panel to comprehensively assess the DNA methylation status...
March 2, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28193491/linked-color-imaging-improves-endoscopic-visibility-of-colorectal-nongranular-flat-lesions
#13
Takuto Suzuki, Taro Hara, Yoshiyasu Kitagawa, Hideyuki Takashiro, Rino Nankinzan, Osamu Sugita, Taketo Yamaguchi
BACKGROUND AND AIMS: As a newly developed image-enhanced endoscopy (IEE) technique, linked-color imaging (LCI) provides very bright images with enhanced color tones. With the objective of improving the detection rate of colorectal flat tumor lesions, which are difficult to detect, we examined the usefulness of LCI from the viewpoint of visibility. METHODS: Fifty-three consecutive nongranular flat tumors were used in this study. Endoscopic images were acquired by white-light imaging (WLI), blue-laser imaging (BLI)-bright, and LCI modes...
February 10, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28182112/prevalence-and-anatomic-distribution-of-serrated-and-adenomatous-lesions-in-patients-with-inflammatory-bowel-disease
#14
Lik Hang Lee, Marietta Iacucci, Miriam Fort Gasia, Subrata Ghosh, Remo Panaccione, Stefan Urbanski
Background. Sessile serrated adenomas/polyps (SSA/Ps) and traditional serrated adenomas (TSAs) have not been well characterized in patients with inflammatory bowel disease (IBD). This study assesses the prevalence and anatomic distribution of SSA/Ps, TSAs, and conventional adenomas/dysplasia (Ad/Ds) in IBD patients. Methods. IBD patients with serrated, adenomatous, or hyperplastic lesions between 2005 and 2009 were identified in the regional tertiary-care hospital database. Clinicopathological information was reviewed and the histology of biopsies was reevaluated...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28160332/histopathological-analysis-of-cold-snare-polypectomy-and-its-indication-for-colorectal-polyps-10-14mm-in-diameter
#15
Ryohei Hirose, Naohisa Yoshida, Takaaki Murakami, Kiyoshi Ogiso, Yutaka Inada, Osamu Dohi, Tetsuya Okayama, Kazuhiro Kamada, Kazuhiko Uchiyama, Osamu Handa, Takeshi Ishikawa, Hideyuki Konishi, Yuji Naito, Yasuko Fujita, Mitsuo Kishimoto, Akio Yanagisawa, Yoshito Itoh
BACKGROUND AND AIM: Cold snare polypectomy (CSP) is commonly used for treating colorectal polyps <10 mm in diameter. We evaluated the histopathological and safety of CSP for larger polyps. METHODS: We retrospectively analyzed 1,006 colorectal polyps resected with CSP. The indication for CSP was polyps 2-14 mm that were diagnosed as benign neoplastic polyp by magnifying endoscopy. Various clinicopathological characteristics were analyzed. Multivariate analyses were utilized to determine the independent risk factors for failure of complete CSP resection...
February 3, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28078114/colorectal-cancer-anatomic-distribution-patterns-remain-the-same-after-sessile-serrated-adenoma-polyp-considered-cancer-precursor-a-9-year-comparison-study-from-community-based-endoscopy-centers
#16
Juliana F Yang, Amy E Noffsinger, Deepak Agrawal, Qing-Hua Yang
BACKGROUND: The overall incidence of colorectal cancer (CRC) in the United States has steadily decreased. However, the incidence of right-sided CRC remains unchanged for the past two decades. The serrated neoplastic pathway (sessile serrated adenoma/polyp, SSA/P) has been considered an important pathway of colorectal carcinogenesis, especially in the right-sided CRC. The aim of this study was to compare CRC anatomic distribution patterns in a 9-year interval in the general population before and after SSA/P was recognized and treated as a CRC precursor...
December 2016: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28069476/missed-adenomas-with-behind-folds-visualizing-colonoscopy-technologies-compared-with-standard-colonoscopy-a-pooled-analysis-of-3-randomized-back-to-back-tandem-colonoscopy-studies
#17
Eelco C Brand, Vincent K Dik, Martijn G H van Oijen, Peter D Siersema
BACKGROUND AND AIMS: The Third Eye Retroscope, Full Spectrum Endoscope (FUSE), and EndoRings devices have been shown to reduce overall adenoma miss rates. We evaluated the characteristics of adenomas and patient subgroups for which these behind-folds visualizing technologies mostly reduce adenoma miss rates. METHODS: Data of 3 multicenter randomized trials (NCT01044732, NCT01549535, NCT01955122) were combined. Patients underwent same-day, back-to-back tandem examinations with standard colonoscopy and Third Eye Retroscope, FUSE, or EndoRings colonoscopy, respectively...
January 6, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28052292/evaluation-for-the-clinical-efficacy-of-colon-capsule-endoscopy-in-the-detection-of-laterally-spreading-tumors
#18
COMPARATIVE STUDY
Atsushi Igawa, Shiro Oka, Shinji Tanaka, Ichiro Otani, Sayoko Kunihara, Kazuaki Chayama
BACKGROUND AND AIM: The manner in which colorectal lesions are being detected with PillCam COLON2 capsule endoscopy (CCE2) has markedly improved in recent days. However, limited data are available on CCE2 for detecting laterally spreading tumors (LSTs). The aim of this study was to compare CCE2 with optical colonoscopy (OC), which is currently the gold standard used in the detection of LSTs. METHODS: We performed a prospective, single-academic center study comparing CCE2 with OC in patients with LSTs diagnosed using OC, which was performed during the 3-month period prior to CCE2...
2017: Digestion
https://www.readbyqxmd.com/read/28038683/the-gut-microbiota-in-conventional-and-serrated-precursors-of-colorectal-cancer
#19
Brandilyn A Peters, Christine Dominianni, Jean A Shapiro, Timothy R Church, Jing Wu, George Miller, Elizabeth Yuen, Hal Freiman, Ian Lustbader, James Salik, Charles Friedlander, Richard B Hayes, Jiyoung Ahn
BACKGROUND: Colorectal cancer is a heterogeneous disease arising from at least two precursors-the conventional adenoma (CA) and the serrated polyp. We and others have previously shown a relationship between the human gut microbiota and colorectal cancer; however, its relationship to the different early precursors of colorectal cancer is understudied. We tested, for the first time, the relationship of the gut microbiota to specific colorectal polyp types. RESULTS: Gut microbiota were assessed in 540 colonoscopy-screened adults by 16S rRNA gene sequencing of stool samples...
December 30, 2016: Microbiome
https://www.readbyqxmd.com/read/28035250/from-traditional-serrated-adenoma-to-tubulovillous-adenoma-and-beyond
#20
REVIEW
Sangeetha N Kalimuthu, Adeline Chelliah, Runjan Chetty
It is well established that colorectal cancer develops from a series of precursor epithelial polyps, including tubular adenomas, villous/tubulovillous adenomas (VA/TVA), sessile serrated adenomas (SSA) and traditional serrated adenomas (TSA). Of these, TSAs are least common and account for only 5% of all serrated polyps. TSAs are characterised by the presence of a "pinecone-like" architecture, granular eosinophilic cytoplasm, luminal serrations, ectopic crypt foci (ECF) and elongated, pencillate nuclei. However, the distinct slit-like luminal serrations, reminiscent of small bowel mucosa, appear to be the most unique and reproducible feature to distinguish TSAs from other polyps...
December 15, 2016: World Journal of Gastrointestinal Oncology
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