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Serrated polyp

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https://www.readbyqxmd.com/read/28927131/protein-expression-of-fragile-histidine-triad-and-cyclooxgenase-2-in-serrated-neoplasia-of-the-colorectum
#1
Akihiro Tamoto, Kazuo Yashima, Kohei Hosoda, Sohei Yamamoto, Soichiro Kawata, Yuichiro Ikebuchi, Kazuya Matsumoto, Koichiro Kawaguchi, Kenichi Harada, Yoshikazu Murawaki, Hajime Isomoto
The adenoma-carcinoma sequence (ACS) and the serrated pathway are two distinct developmental routes leading to the formation of colorectal carcinoma (CRC). However, the mechanism triggered by the serrated pathway remains unclear. Therefore, to clarify the molecular and clinicopathological characteristics of the serrated tumorigenic pathway, immunohistochemistry was used to examine the expression of Fragile Histidine Triad (FHIT), cyclooxygenase-2 (COX-2), MutL homolog 1 (MLH1), MutS protein homolog 2 (MSH2) and P53 in endoscopically resected samples of 62 serrated polyps...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28924598/carbon-dioxide-insufflation-is-associated-with-increased-serrated-polyp-detection-rate-when-compared-to-room-air-insufflation-during-screening-colonoscopy
#2
Michael Riverso, Yaseen B Perbtani, Jonathan J D Shuster, Joydeep Chakraborty, Tony S Brar, Mitali Agarwal, Han Zhang, Anand Gupte, Shailendra S Chauhan, Christopher E Forsmark, Peter V Draganov, Dennis Yang
BACKGROUND AND STUDY AIMS : Sessile serrated adenomas (SSA) and traditional serrated adenomas (TSA) have been increasingly recognized as precursors of colorectal cancer. The aim of this study was to compare the effect of carbon dioxide insufflation (CO 2 I) vs. room air insufflation (AI) on serrated polyp detection rate (SPDR) and to identify factors associated with SPDR. PATIENTS AND METHODS : Single-center retrospective cohort study of 2083 screening colonoscopies performed with AI (November 2011 through January 2013) or CO 2 I (February 2013 to June 2015)...
September 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28906425/impact-of-changeover-to-newer-endoscopic-systems-on-quality-and-efficiency-of-screening-and-surveillance-colonoscopy-equipment-or-endoscopist
#3
Manpreet Singh, Melody Sacatos, Loren Laine
GOALS: The goal of this study is to assess whether changeover to newer endoscopic systems impacts quality or efficiency, and quantify the relation between increased withdrawal time and detection rates of sessile serrated polyps (SSPDR) and adenomas (ADR) in real-world practice. STUDY: Beginning 2 months after new endoscopic systems were implemented at 2 endoscopy units, we included all outpatients undergoing screening/surveillance colonoscopy for 4 months. Outpatients during the same 4-month period 1 year earlier comprised the control group...
September 12, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28890813/endocuff-assisted-colonoscopy-significantly-increases-sessile-serrated-adenoma-detection-in-veterans
#4
Michael D Baek, Christian S Jackson, John Lunn, Chris Nguyen, Nicole K Shah, Steve Serrao, David Juma, Richard M Strong
BACKGROUND: Colorectal cancer (CRC) is the second most common cause of cancer related deaths in the United States. Colonoscopy is the gold standard for the detection of CRC. There are many colonoscopy quality measures and among these the adenoma detection rate (ADR) has demonstrated a significant impact in reducing mortality from CRC. The primary aim of our study was to compare ADR and distribution of polyp type in patients undergoing Endocuff-assisted colonoscopy (EAC) versus standard colonoscopy (SC) in a VA system...
August 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28865167/colorectal-surveillance-after-segmental-resection-for-young-onset-colorectal-cancer-is-there-evidence-for-extended-resection
#5
V N Kozak, M F Kalady, M M Gamaleldin, J Liang, J M Church
AIM: Although sporadic colorectal cancer (CRC) usually occurs in patients over 50, recent evidence suggests that the incidence is increasing in younger patients. Such patients are theoretically at high risk of metachronous neoplasia and may be candidates for extended, prophylactic, colectomy. This study aimed to define the risk of metachronous cancer/adenomas during follow-up of younger patients who underwent segmental colectomy for CRC. METHOD: A CRC database was used to identify patients aged less than 50 who underwent surgery for CRC between 1994 and 2010...
September 2, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28855108/squamoid-morules-in-the-pseudoinvasive-foci-of-colonic-polyp-morphologically-mimic-invasive-carcinoma
#6
Hee Eun Lee, Vishal S Chandan, Chung-Ta Lee, Tsung-Teh Wu
Colorectal adenomas can show focal squamous differentiation or squamoid morules. We describe histologic findings of squamoid morules in the pseudoinvasive foci of colorectal polyps mimicking invasive carcinoma. Five colonic polyps with squamoid morules in the pseudoinvasive foci were collected. Histologic review and immunostains for cytokeratin (CK) 5/6, p63, synaptophysin, and chromogranin were performed on cases with squamoid morules. Forty-seven consecutive colorectal polyps with pseudoinvasion, none of which showed squamoid morules by histology review, and their clinicopathologic features were compared with the cases containing squamoid morules...
August 27, 2017: Human Pathology
https://www.readbyqxmd.com/read/28853002/the-serrated-polyp-pathway-is-it-time-to-alter-surveillance-guidelines
#7
REVIEW
Brendon O'Connell, Nazar Hafiz, Seth Crockett
PURPOSE OF REVIEW: In this manuscript, we review current surveillance guidelines for serrated polyps (SPs) and discuss how recent studies inform the selection of appropriate surveillance intervals for patients with SPs. RECENT FINDINGS: Large and/or proximal SPs, particularly sessile serrated polyps (SSPs), are associated with increased risk of both synchronous and metachronous neoplasia, including advanced adenomas and colorectal cancer (CRC). Persons harboring multiple SSPs or dysplastic SSPs are at the highest risk...
August 29, 2017: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/28843582/diagnosis-of-sessile-serrated-adenoma-after-educational-training-in-a-large-community-based-integrated-healthcare-setting
#8
Dan Li, John Woolfrey, Sheng-Fang Jiang, Christopher D Jensen, Wei K Zhao, Sanjay Kakar, Monica Santamaria, Greg Rumore, Mary Anne Armstrong, Debbie Postlethwaite, Douglas A Corley, Theodore R Levin
BACKGROUND AND AIMS: Sessile serrated adenomas (SSAs) are precursors of 15% to 30% of colorectal cancers but are frequently underdiagnosed. We sought to measure the SSA detection rate (SDR) and predictors of SSA detection after educational training for community gastroenterologists and pathologists. METHODS: Colonoscopy and pathology data (2010-2014) from 3 medical centers at Kaiser Permanente Northern California were accessed electronically. Gastroenterologists and pathologists attended a training session on SSA diagnosis in 2012...
August 23, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28842058/distribution-of-colorectal-polyps-implications-for-screening
#9
REVIEW
Carlo Senore, Cristina Bellisario, Nereo Segnan
BACKGROUND: During the last decades data from different studies reported modifications of the topographic distribution of colorectal cancers (CRCs), with an increased frequency of tumours in proximal colonic segments. Given the documented link between adenomas and CRC, a proximal migration of adenomas over time could be expected as well. AIM: To evaluate available evidence about the prevalence of adenomas and of sessile serrated polyps across colonic segments, the changing trends in their distribution across the colon and the diagnostic performance of screening tests currently adopted in population based screening programs for lesions located in different colonic segments...
August 2017: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/28842051/epidemiology-and-risk-factors-of-colorectal-polyps
#10
REVIEW
Mari Øines, Lise M Helsingen, Michael Bretthauer, Louise Emilsson
The lifetime risk of colorectal cancer (CRC) in the Western world is around 5%. CRC commonly develops from precursor lesions termed polyps, classified as adenomatous or serrated polyps according to growth pattern. Despite the well-known connection between polyps and cancer, most polyps will never develop into CRC. For those that do, the time until CRC development is generally thought of as >10 years. This gives opportunity for interventional strategies to prevent transformation into cancer. This article aims to provide an overview of the epidemiology of and risk factors for colorectal polyps in the average risk population, and will encompass the effect of age, gender, ethnicity, smoking, obesity, alcohol, physical activity, NSAIDs and dietary factors on colorectal polyps...
August 2017: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/28828201/deep-learning-for-classification-of-colorectal-polyps-on-whole-slide-images
#11
Bruno Korbar, Andrea M Olofson, Allen P Miraflor, Catherine M Nicka, Matthew A Suriawinata, Lorenzo Torresani, Arief A Suriawinata, Saeed Hassanpour
CONTEXT: Histopathological characterization of colorectal polyps is critical for determining the risk of colorectal cancer and future rates of surveillance for patients. However, this characterization is a challenging task and suffers from significant inter- and intra-observer variability. AIMS: We built an automatic image analysis method that can accurately classify different types of colorectal polyps on whole-slide images to help pathologists with this characterization and diagnosis...
2017: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/28816376/acetic-acid-indigo-carmine-mixture-for-evaluating-the-margins-of-sessile-serrated-adenomas-polyps
#12
Shunsuke Yamamoto, Morteza Shafazand
Sessile serrated adenomas/polyps (SSA/Ps) have attracted increasing attention since their risk of developing into cancer was clarified [1]. Difficulty in determining their margins causes incomplete resection [2]. Although narrow-band imaging (NBI) and other advanced imaging systems are reportedly useful in evaluating these polyps [3, 4]. This article is protected by copyright. All rights reserved.
August 17, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28791327/use-of-endocytoscopy-for-identification-of-sessile-serrated-adenoma-polyps-and-hyperplastic-polyps-by-quantitative-image-analysis-of-the-luminal-areas
#13
Yushi Ogawa, Shin-Ei Kudo, Yuichi Mori, Nobunao Ikehara, Yasuharu Maeda, Kunihiko Wakamura, Masashi Misawa, Toyoki Kudo, Takemasa Hayashi, Hideyuki Miyachi, Atsushi Katagiri, Fumio Ishida, Haruhiro Inoue
BACKGROUND AND STUDY AIMS:  Recent studies that used magnifying chromoendoscopy and endocytoscopy (EC) to investigate endoscopic features of sessile serrated adenoma/polyps (SSA/Ps) suggested that a dilated crypt opening was an important indicator of SSA/Ps. However, no studies to date have measured the actual extent of dilatation. Hence, we investigated retrospectively the luminal areas using EC to determine a cutoff value for differentiating SSA/Ps from hyperplastic polyps (HPs). PATIENTS AND METHODS : A total of 101 lesions, including 25 SSA/Ps, 66 HPs, and 10 normal mucosal samples, assessed by an integrated-type EC were collected...
August 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28759612/scheduling-rules-for-patients-with-diabetes-mellitus-that-facilitate-split-dosing-improve-the-quality-of-bowel-preparation-for-colonoscopy
#14
Robert J Hilsden, Ronald Bridges, Catherine Dube, Steven J Heitman, Alaa Rostom
BACKGROUND & AIMS: An adequate bowel preparation for colonoscopy is best achieved by giving the cleansing regimen as a split-dose with the second dose given 4-6 hours before the procedure. This can be difficult to administer to diabetics who are preferentially scheduled for early morning procedures. We examined the impact on bowel preparation quality of scheduling diabetics for mid-morning (9:30 am or later) procedures rather than early morning procedures (7:30-9:00 AM) to facilitate a split-dose preparation...
2017: PloS One
https://www.readbyqxmd.com/read/28752838/sessile-serrated-adenomas-with-dysplasia-morphological-patterns-and-correlations-with-mlh1-immunohistochemistry
#15
Cheng Liu, Neal I Walker, Barbara A Leggett, Vicki Lj Whitehall, Mark L Bettington, Christophe Rosty
Sessile serrated adenomas are the precursor polyp of approximately 20% of colorectal carcinomas. Sessile serrated adenomas with dysplasia are rarely encountered and represent an intermediate step to malignant progression, frequently associated with loss of MLH1 expression. Accurate diagnosis of these lesions is important to facilitate appropriate surveillance, particularly because progression from dysplasia to carcinoma can be rapid. The current World Health Organization classification describes two main patterns of dysplasia occurring in sessile serrated adenomas, namely, serrated and conventional...
July 28, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28746986/the-histopathological-classification-diagnosis-and-differential-diagnosis-of-mucinous-appendiceal-neoplasms-appendiceal-adenocarcinomas-and-pseudomyxoma-peritonei
#16
REVIEW
Norman J Carr, Frederic Bibeau, Robert F Bradley, Peggy Dartigues, Roger M Feakins, Kim R Geisinger, Xianyong Gui, Sylvie Isaac, Massimo Milione, Joseph Misdraji, Reetesh K Pai, Manuel Rodriguez-Justo, Leslie H Sobin, Marie-Louise F van Velthuysen, Rhonda K Yantiss
The vermiform appendix is the primary site of several distinctive benign and malignant neoplasms. Some can produce the clinical syndrome of pseudomyxoma peritonei (PMP). A consensus on their terminology was reached by an international panel of pathologists and clinicians working under the auspices of the Peritoneal Surface Oncology Group International (PSOGI) and this review discusses the application of the PSOGI classification to routine reporting. We discuss diagnosis and differential diagnosis together with implications for patient management, covering low-grade appendiceal mucinous neoplasms, high-grade appendiceal mucinous neoplasms, serrated polyps, adenomas, and adenocarcinomas...
July 26, 2017: Histopathology
https://www.readbyqxmd.com/read/28723863/factors-associated-with-classification-of-hyperplastic-polyps-as-sessile-serrated-adenomas-polyps-on-morphologic-review
#17
Joseph C Anderson, Mikhail Lisovsky, Mary A Greene, Catherine Hagen, Amitabh Srivastava
BACKGROUND: Distinguishing sessile serrated adenomas/polyp (SSA/P), a subset of serrated polyps, from hyperplastic polyps (HPs) remains a challenge and has surveillance implications. Our goal was to identify clinical and pathologic factors associated with serrated polyps originally read as HPs being reassessed as SSA/Ps versus confirmed as HPs. METHODS: Data were collected from consecutive patients with a right-sided HP and a corresponding comparison group with conventional adenomas between 1993 and 2003...
July 18, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28713972/expression-and-subcellular-localization-of-at-motif-binding-factor-1-in-colon-tumours
#18
Hiromi Kataoka, Yutaka Miura, Makoto Kawaguchi, Shugo Suzuki, Yasuyuki Okamoto, Keiji Ozeki, Takaya Shimura, Tsutomu Mizoshita, Eiji Kubota, Satoshi Tanida, Satoru Takahashi, Kiyofumi Asai, Takashi Joh
AT motif binding factor 1 (ATBF1) is a transcriptional regulator that functions as a tumour suppressor to negatively affect cancer cell growth. In the present study four specific polyclonal antibodies against ATBF1 were generated, and the expression and intracellular localization of ATBF1 in colonic mucosae, polyps, adenoma and adenocarcinoma tissue samples were investigated. The four polyclonal antibodies produced were as follows: MB34 and MB49, which recognize the N‑ and C‑terminal fragments of ATBF1, respectively; and D1‑120 and MB44, which recognize the middle fragments of ATBF1 that contain three nuclear localization signals (NLS)...
September 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28713060/a-standardized-imaging-protocol-for-the-endoscopic-prediction-of-dysplasia-within-sessile-serrated-polyps-with-video
#19
David J Tate, Mahesh Jayanna, Halim Awadie, Lobke Desomer, Ralph Lee, Stephen J Heitman, Mayenaaz Sidhu, Kathleen Goodrick, Nicholas G Burgess, Hema Mehajan, Duncan McLeod, Michael J Bourke
BACKGROUND AND AIMS: Dysplasia within sessile serrated polyps (SSPs) is difficult to detect, may be mistaken for an adenoma risking incomplete resection of the background serrated tissue, and is strongly implicated in interval cancer after colonoscopy. The use of endoscopic imaging to detect dysplasia within SSP has not been systematically studied. METHODS: Consecutively detected SSP ≥8 mm in size were evaluated using a standardized imaging protocol at a tertiary endoscopy center over 3 years...
July 13, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28712761/detection-diagnosis-and-resection-of-sessile-serrated-adenomas-and-polyps
#20
Jennifer M Kolb, Roy M Soetikno, Aarti K Rao, Dean Fong, Robert V Rouse, Tonya Kaltenbach
No abstract text is available yet for this article.
September 2017: Gastroenterology
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