keyword
MENU ▼
Read by QxMD icon Read
search

Serrated polyp

keyword
https://www.readbyqxmd.com/read/27925331/the-mirna-landscape-of-colorectal-polyps
#1
Martha L Slattery, Jennifer S Herrick, Roger K Wolff, Lila E Mullany, John R Stevens, Wade Samowitz
The genomic landscape of adenomas and polyps may help define disease pathways. Expression of miRNAs in adenomas and polyps may importantly contribute to these pathways. We evaluated miRNA expression in 293 polyp-normal colorectal mucosa pairs. Polyps were classified as either adenomatous polyp (AD), hyperplastic polyp (HP), or sessile serrated polyp (SSP). We compared these miRNA expression profiles in polyps to miRNA expression in microsatellite unstable (MSI) and stable (MSS) tumors. A False Discovery Rate (FDR) of 0...
December 7, 2016: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/27920485/use-of-the-endocuff-during-routine-colonoscopy-examination-improves-adenoma-detection-a-meta-analysis
#2
Matthew Chin, William Karnes, M Mazen Jamal, John G Lee, Robert Lee, Jason Samarasena, Matthew L Bechtold, Douglas L Nguyen
AIM: To perform meta-analysis of the use of Endocuff during average risk screening colonoscopy. METHODS: Scopus, Cochrane databases, MEDLINE/PubMed, and CINAHL were searched in April 2016. Abstracts from Digestive Disease Week, United European Gastroenterology, and the American College of Gastroenterology meeting were also searched from 2004-2015. Studies comparing EC-assisted colonoscopy (EAC) to standard colonoscopy, for any indication, were included in the analysis...
November 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27906163/expression-of-annexin-a10-in-serrated-polyps-predicts-the-development-of-metachronous-serrated-polyps
#3
Carole Macaron, Rocio Lopez, Rish K Pai, Carol A Burke
OBJECTIVES: The ability to differentiate histological characteristics between serrated polyps (SPs) and make a pathological diagnosis of a sessile serrated polyp (SSP) is highly variable. Recent studies have shown that immunohistochemical (IHC) expression of Annexin A10 (ANXA10) is a marker of a SSP. However, the clinical utility of ANXA10 expression in patients with SPs is unknown. The objective of this study was to evaluate the utility of ANXA10 expression in SPs in predicting the development of subsequent polyps at follow-up colonoscopy...
December 1, 2016: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/27888868/novel-findings-in-colorectal-polyp-surveillance
#4
Sabela Carballal
Colorectal adenomas and serrated polyps are the best characterised premalignant lesions involved in the development of colorectal cancer (CRC). Therefore, the identification and removal of these lesions, as well as post-polypectomy surveillance of affected patients, are key goals in the field of CRC prevention. Current post-polypectomy surveillance strategies differ among the various scientific societies and have several limitations that hamper their application in clinical practice. First, current surveillance intervals are based only on polyp characteristics, excluding other potential clinical conditions, such as diabetes or metabolic syndrome...
September 2016: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/27884518/multi-target-stool-dna-test-clinical-performance-and-impact-on-yield-and-quality-of-colonoscopy-for-colorectal-cancer-screening
#5
David H Johnson, John B Kisiel, Kelli N Burger, Douglas W Mahoney, Mary E Devens, David A Ahlquist, Seth Sweetser
BACKGROUND & AIMS: Multi-target stool DNA testing (MT-sDNA) is now FDA-approved for average-risk CRC screening. Trials leading to its approval used blinded colonoscopy as the reference standard. In the post-approval screen setting, the clinical performance and impact of MT-sDNA on unblinded colonoscopy has not been described. We measured the impact that knowledge of a positive MT-sDNA test result has on colonoscopy yield and quality. METHODS: The unblinded group comprised all patients with positive MT-sDNA results on screening from 9/1/14-9/30/15 at a single tertiary center...
November 21, 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27860102/high-prevalence-of-sessile-serrated-adenomas-in-contemporary-outpatient-colonoscopy-practice
#6
Mark Bettington, Neal Walker, Tony Rahman, Ann Vandeleur, Vicki Whitehall, Barbara Leggett, John Croese
BACKGROUND: Sessile serrated adenomas are the polyp precursor of 15-20% of colorectal carcinomas. There is debate about their prevalence and increasing discussion about the need for a serrated polyp detection rate as a quality indicator for colonoscopy. AIMS: We aimed to assess the prevalence of sessile serrated adenomas at an outpatient gastroenterology service. METHODS: This is a retrospective study of an unselected consecutive series of patients who had an outpatient colonoscopy between April 2013 and May 2014...
November 16, 2016: Internal Medicine Journal
https://www.readbyqxmd.com/read/27859949/the-clinicopathological-significance-of-spc18-in-colorectal-cancer-spc18-participates-in-tumor-progression
#7
Takuya Hattori, Kazuhiro Sentani, Naohide Oue, Naoya Sakamoto, Wataru Yasui
Colorectal cancer (CRC) is one of the leading causes of cancer-related death worldwide. In order to identify novel prognostic markers or therapeutic targets for CRC, we searched for candidate genes in our comprehensive gene expression libraries, and focused on SEC11A, which encodes the SPC18 protein. SPC18 plays a key role in the endoplasmic reticulum-Golgi secretory pathway and presumably regulates the secretion of various secretory proteins. An immunohistochemical analysis of SPC18 in 137 CRC tissue samples demonstrated that 79 (58%) CRC cases were positive for SPC18...
November 17, 2016: Cancer Science
https://www.readbyqxmd.com/read/27852795/modifiable-lifestyle-factors-associated-with-risk-of-sessile-serrated-polyps-conventional-adenomas-and-hyperplastic-polyps
#8
James R Davenport, Timothy Su, Zhiguo Zhao, Helen G Coleman, Walter E Smalley, Reid M Ness, Wei Zheng, Martha J Shrubsole
OBJECTIVE: To identify modifiable factors associated with sessile serrated polyps (SSPs) and compare the association of these factors with conventional adenomas (ADs) and hyperplastic polyps (HPs). DESIGN: We used data from the Tennessee Colorectal Polyp Study, a colonoscopy-based case-control study. Included were 214 SSP cases, 1779 AD cases, 560 HP cases and 3851 polyp-free controls. RESULTS: Cigarette smoking was associated with increased risk for all polyps and was stronger for SSPs than for ADs (OR 1...
November 15, 2016: Gut
https://www.readbyqxmd.com/read/27847280/serrated-polyp-detection-by-the-fecal-immunochemical-test-an-imperfect-fit
#9
EDITORIAL
Joseph C Anderson, Douglas J Robertson
No abstract text is available yet for this article.
November 12, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27819306/decreased-preoperative-serum-25-hydroxyvitamin-d-levels-in-colorectal-cancer-are-associated-with-systemic-inflammation-and-serrated-morphology
#10
Juha P Väyrynen, Shivaprakash J Mutt, Karl-Heinz Herzig, Sara A Väyrynen, Tiina Kantola, Toni Karhu, Tuomo J Karttunen, Kai Klintrup, Jyrki Mäkelä, Markus J Mäkinen, Anne Tuomisto
Deficiency of vitamin D is associated with increased risk of several types of cancer including colorectal cancer (CRC). However, factors contributing to low levels of 25-hydroxyvitamin D [25(OH)D] in CRC are not clear. Therefore, in this study serum 25(OH)D levels in 117 CRC patients and 86 controls were analyzed and correlated with the clinicopathological data including morphological subtype (serrated or conventional), quantity of tumor infiltrating immune cells, levels of systemic inflammatory markers, and disease outcome...
November 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27784967/interendoscopist-variability-in-proximal-colon-polyp-detection-is-twice-higher-for-serrated-polyps-than-adenomas
#11
Jean-François Bretagne, Stéphanie Hamonic, Christine Piette, Jean-François Viel, Guillaume Bouguen
AIM: To assess the interendoscopist variability in the detection of colorectal polyps according to their location and histological type. METHODS: This study was a retrospective analysis of prospectively collected data from a regional colorectal cancer (CRC) screening program; 2979 complete colonoscopies from 18 endoscopists were included. Variability in performance between endoscopists for detection of at least one adenoma (A), one proximal adenoma (PA), one distal adenoma (DA), and one proximal serrated polyp (PSP) was assessed by using multilevel logistic regression models...
October 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27783336/attenuated-polyposis-of-the-large-bowel-a-morphologic-and-molecular-approach
#12
Maurizio Ponz de Leon, Monica Pedroni, Luca Roncucci, Federica Domati, Giuseppina Rossi, Giulia Magnani, Annalisa Pezzi, Rossella Fante, Luca Reggiani Bonetti
Attenuated polyposis could be defined as a variant of familial adenomatous polyposis (FAP) in which synchronous polyps of the large bowel range between 10 and 99. We analysed all cases of attenuated polyposis observed over the last 30 years with the objectives: (A) to classify the disease according to different type and proportion of polyps; (B) To ascertain the contribution of APC and MutYH genes; (C) to discover features which could arise the suspicion of mutations; (D) To obtain indications for management and follow-up...
October 25, 2016: Familial Cancer
https://www.readbyqxmd.com/read/27781259/-research-progress-of-serrated-polyposis-syndrome
#13
Shihao Dong, Jingsong Chen
Serrated polyposis syndrome (SPS) is closely associated with the initiation and development of colorectal cancer (CRC), however, there is few research on SPS in China. Serrated polyps can be divided into hyperplastic polyps, sessile serrated polyps and traditional serrated polyps. The diagnosis standard of SPS is as following: (1) There are at least 5 serrated lesions in proximal colon, and diameter of more than 2 lesions is >10 mm; (2) The patient has one serrated polyp with family history of SPS; (3) More than 20 serrated polyps can be found in the entire large bowel...
October 25, 2016: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/27775962/optical-diagnosis-of-sessile-serrated-polyps-bottleneck-for-the-optical-diagnosis-paradigm
#14
Jasper L A Vleugels, Joep E G IJspeert, Yark Hazewinkel, Manon van der Vlugt, Paul Fockens, Lianne Koens, Evelien Dekker
BACKGROUND: Optical diagnosis of diminutive (1 to 5 mm) polyps could result in a more cost-effective colonoscopy practice. Previous optical diagnosis studies did not incorporate the differentiation of sessile serrated polyps (SSPs). This study aimed to evaluate the impact of optical diagnosis of diminutive SSPs on the overall performance of endoscopic polyp differentiation in daily colonoscopy practice. METHODS: Endoscopy data were prospectively collected between 2011 and 2014 in a colonoscopy center...
October 21, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27771216/prevalence-of-sessile-serrated-adenoma-polyp-in-hyperplastic-appearing-diminutive-rectosigmoid-polyps
#15
Prasanna Ponugoti, Jingmei Lin, Robert Odze, Dale Snover, Charles Kahi, Douglas K Rex
BACKGROUND: The American Society for Gastrointestinal Endoscopy recommends that distal colon hyperplastic lesions can be left in place without resection if adenomatous histology can be excluded with > 90% negative predictive value. However, some of the lesions could be sessile serrated adenoma/polyp (SSA/P), which is also precancerous. AIM: Describe the prevalence of SSA/P in hyperplastic appearing diminutive rectosigmoid polyps. METHODS: We prospectively placed 513 consecutive diminutive rectosigmoid polyps that appeared hyperplastic to an expert endoscopist in individual bottles for pathologic examination...
October 19, 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27751875/the-valley-sign-in-small-and-diminutive-adenomas-prevalence-interobserver-agreement-and-validation-as-an-adenoma-marker
#16
Douglas K Rex, Prasanna Ponugoti, Charles Kahi
BACKGROUND: Classification schemes for differentiation of conventional colorectal adenomas from serrated lesions rely on patterns of blood vessels and pits. Morphologic features have not been validated as predictors of histology. AIM: Describe the prevalence of the "valley sign" and validate it as a marker of conventional adenomas METHODS: Three experts judged the prevalence of the valley sign in 301 consecutive small adenomas. Medical students were taught to recognize the valley and tested on their recognition of the valley sign...
October 14, 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27748334/detection-rate-distribution-clinical-and-pathological-features-of-colorectal-serrated-polyps
#17
Hai-Long Cao, Xue Chen, Shao-Chun Du, Wen-Jing Song, Wei-Qiang Wang, Meng-Que Xu, Si-Nan Wang, Mei-Yu Piao, Xiao-Cang Cao, Bang-Mao Wang
BACKGROUND: Colorectal serrated polyp is considered as histologically heterogeneous lesions with malignant potential in western countries. However, few Asian studies have investigated the comprehensive clinical features of serrated polyps in symptomatic populations. The aim of the study was to evaluate the features of colorectal serrated polyps in a Chinese symptomatic population. METHODS: Data from all consecutive symptomatic patients were documented from a large colonoscopy database and were analyzed...
2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27741536/reassessment-colonoscopy-to-diagnose-serrated-polyposis-syndrome-in-a-colorectal-cancer-screening-population
#18
Liseth Rivero-Sanchez, Maria Lopez-Ceron, Sabela Carballal, Leticia Moreira, Xavier Bessa, Anna Serradesanferm, Angels Pozo, Josep Maria Augé, Teresa Ocaña, Ariadna Sánchez, María Liz Leoz, Míriam Cuatrecasas, Jaume Grau, Josep Llach, Antoni Castells, Francesc Balaguer, Maria Pellisé
Background and study aims: Serrated polyposis syndrome (SPS) is a high risk condition for colorectal cancer (CRC). Surveillance strategies for patients with serrated lesions remain controversial. We aimed to evaluate a diagnostic strategy to detect SPS consistently during reassessment colonoscopy in patients with proximal serrated lesions. Methods: This was a retrospective study of all individuals from a fecal immunochemical test (FIT)-based CRC screening program (2010 - 2013) with one or more serrated lesions of ≥ 5 mm proximal to the sigmoid colon on baseline colonoscopy...
October 14, 2016: Endoscopy
https://www.readbyqxmd.com/read/27713423/downregulation-of-acetyl-coa-synthetase-2-is-a-metabolic-hallmark-of-tumor-progression-and-aggressiveness-in-colorectal-carcinoma
#19
Jeong Mo Bae, Jung Ho Kim, Hyeon Jeong Oh, Hye Eun Park, Tae Hun Lee, Nam-Yun Cho, Gyeong Hoon Kang
Acetyl-CoA synthetase-2 is an emerging key enzyme for cancer metabolism, which supplies acetyl-CoA for tumor cells by capturing acetate as a carbon source under stressed conditions. However, implications of acetyl-CoA synthetase-2 in colorectal carcinoma may differ from other malignancies, because normal colonocytes use short-chain fatty acids as an energy source, which are supplied by fermentation of the intestinal flora. Here we analyzed acetyl-CoA synthetase-2 mRNA expression by reverse-transcription quantitative PCR in paired normal mucosa and tumor tissues of 12 colorectal carcinomas, and subsequently evaluated acetyl-CoA synthetase-2 protein expression by immunohistochemistry in 157 premalignant colorectal lesions, including 60 conventional adenomas and 97 serrated polyps, 1,106 surgically resected primary colorectal carcinomas, and 23 metastatic colorectal carcinomas in the liver...
October 7, 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27705923/mucins-and-associated-o-glycans-based-immunoprofile-for-stratification-of-colorectal-polyps-clinical-implication-for-improved-colon-surveillance
#20
Shiv Ram Krishn, Sukhwinder Kaur, Yuri M Sheinin, Lynette M Smith, Shailendra K Gautam, Asish Patel, Maneesh Jain, Vasthala Juvvigunta, Priya Pai, Audrey J Lazenby, Hemant K Roy, Surinder K Batra
Sessile serrated adenoma/polyps (SSA/P) are premalignant lesions of colorectal cancer that are difficult to distinguish histologically from hyperplastic polyps (HP) of minimal to no malignant potential. Specific markers for differentiating SSA/P from HP can aid clinicians for optimizing colon surveillance intervals. The present study investigates the potential of mucins and associated O-glycans to distinguish SSA/P from HP. Expression of colonic mucins (MUC1, MUC4, MUC17, MUC2, and MUC5AC) and O-glycans [Sialyl LewisA (CA19-9) and Tn/Sialyl-Tn on MUC1] were analyzed in HP (n=33), SSA/P (n=39), and tubular adenoma (TA) (n=36) samples by immunohistochemistry...
September 29, 2016: Oncotarget
keyword
keyword
17611
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"