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Serrated polyp

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https://www.readbyqxmd.com/read/29148927/flat-serrated-polyps-at-ct-colonography-relevance-appearance-and-optimizing-interpretation
#1
David H Kim, Meghan G Lubner, Ashley R Cahoon, B Dustin Pooler, Perry J Pickhardt
Serrated polyps are a recently recognized family of colonic polyps with subgroups that harbor future malignant potential. In the past, the significance of these lesions to the colorectal cancer carcinogenesis pathway was not recognized nor well understood. It is now known that serrated polyps account for approximately one-fourth of all sporadic colorectal cancers. The sessile serrated polyp (SSP) (also known as a sessile serrated adenoma [SSA]) is the main lesion of interest given its prevalence and subtle presentation...
November 17, 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29148535/the-role-of-apc-in-wnt-pathway-activation-in-serrated-neoplasia
#2
Jennifer Borowsky, Troy Dumenil, Mark Bettington, Sally-Ann Pearson, Catherine Bond, Lochlan Fennell, Cheng Liu, Diane McKeone, Christophe Rosty, Ian Brown, Neal Walker, Barbara Leggett, Vicki Whitehall
Conventional adenomas are initiated by APC gene mutation that activates the WNT signal. Serrated neoplasia is commonly initiated by BRAF or KRAS mutation. WNT pathway activation may also occur, however, to what extent this is owing to APC mutation is unknown. We examined aberrant nuclear β-catenin immunolocalization as a surrogate for WNT pathway activation and analyzed the entire APC gene coding sequence in serrated and conventional pathway polyps and cancers. WNT pathway activation was a common event in conventional pathway lesions with aberrant nuclear immunolocalization of β-catenin and truncating APC mutations in 90% and 89% of conventional adenomas and 82% and 70% of BRAF wild-type cancers, respectively...
November 17, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29147879/increased-risk-for-colon-polyps-in-patients-with-reflux-disease
#3
Amnon Sonnenberg, Kevin O Turner, Robert M Genta
BACKGROUND: Previous studies have found an increased risk for colonic neoplasm in patients with Barrett's esophagus. It is unknown whether such risk applies similarly to other types of gastroesophageal reflux disease (GERD). AIMS: To test whether GERD represents a risk factor for the occurrence of colon polyps. METHODS: The Miraca Life Sciences Database is a large national electronic repository of histopathologic records of patients distributed throughout the entire USA...
November 17, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29133196/cold-endoscopic-mucosal-resection-of-large-sessile-serrated-polyps-at-colonoscopy-with-video
#4
Nicholas J Tutticci, David G Hewett
BACKGROUND AND AIMS: The optimal technique for the resection of sessile serrated polyps (SSPs) is unknown, with established limitations and risks with conventional polypectomy. Although cold snare polypectomy is safe, the efficacy of piecemeal resection for large lesions is untested. In this study, we evaluate the safety and efficacy of cold endoscopic mucosal resection (EMR) for large SSPs. METHODS: Patients presenting for elective colonoscopy at an academic endoscopy center with 1 or more SSPs ≥10mm in size were enrolled, excluding those on anticoagulants or antiplatelets other than aspirin...
November 10, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29081443/colonoscopy-examination-requires-a-longer-time-in-patients-with-acromegaly-than-in-other-individuals
#5
Masaya Iwamuro, Miho Yasuda, Kou Hasegawa, Satoshi Fujisawa, Kanako Ogura-Ochi, Yuusaku Sugihara, Keita Harada, Sakiko Hiraoka, Hiroyuki Okada, Fumio Otsuka
This study aimed to determine the prevalence of colorectal neoplasms and to investigate the rate of and time required for cecal intubation in patients with acromegaly. A database search performed at our institution identified 29 patients with acromegaly who underwent colonoscopy. Data regarding the endoscopic, biological, and pathological examinations performed were retrospectively reviewed from the clinical records. Subsequently, the rate of and time required for cecal intubation were investigated in 23 patients with acromegaly and compared with the corresponding data of the control group...
October 28, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/29065437/basic-bli-adenoma-serrated-international-classification-classification-for-colorectal-polyp-characterization-with-blue-light-imaging
#6
Raf Bisschops, Cesare Hassan, Pradeep Bhandari, Emmanuel Coron, Helmut Neumann, Oliver Pech, Loredana Correale, Alessandro Repici
Backgound and study aim Advanced endoscopic imaging has revolutionized the characterization of lesions during colonoscopy. The aim of this study was to create a new classification for differentiating subcentimetric hyperplastic and adenomatous polyps, and deeply invasive malignant lesions using blue-light imaging (BLI) with high definition, with and without optical magnification, as well as to assess its interobserver concordance. Methods A video library consisting of 48 videos/still images (with/without optical magnification) from 24 histologically verified polyps/cancer with BLI was prospectively created...
October 24, 2017: Endoscopy
https://www.readbyqxmd.com/read/29049128/changing-pathological-diagnosis-from-hyperplastic-polyp-to-sessile-serrated-adenoma-systematic-review-and-meta-analysis
#7
Yaron Niv
The WHO published a new classification of colonic polyps in 2010, including the group of serrated polyps, which can be divided into hyperplastic polyps (HP), traditional serrated adenomas, and sessile serrated adenomas (SSA) or polyps. To assess the rate of re-diagnosis of HP to SSA and to look for possible predictors for changing the diagnosis. English Medical literature searches were performed for 'reassessment' OR 'reclassification' AND 'hyperplastic polyp' OR 'sessile serrated adenoma' till 31 January 2017...
October 18, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29043592/factors-associated-with-surveillance-adenoma-and-sessile-serrated-polyp-detection-rates
#8
Jennifer K Maratt, Joseph Dickens, Philip S Schoenfeld, Grace H Elta, Kenya Jackson, Daniel Rizk, Christine Erickson, Stacy B Menees
BACKGROUND: Adenoma detection rate (ADR) and sessile serrated polyp detection rate (SSPDR) data in surveillance colonoscopy are limited. AIMS: Our aim was to determine surveillance ADR and SSPDR and identify associated predictors. METHODS: A retrospective review of subjects who underwent surveillance colonoscopy for adenoma and/or SSP at an academic center was performed. The following exclusion criteria were applied: prior colonoscopy ≤ 3 years, incomplete examination, or another indication for colonoscopy...
December 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28979711/clinical-predictors-for-sessile-serrated-polyposis-syndrome-a-case-control-study
#9
Yang Wu, Alexander Mullin, Alina Stoita
AIM: To compared individuals with serrated polyposis syndrome (SPS) to those with sessile serrated adenoma (SSA) and adenomas in the setting of endoscopists with high adenoma detection rates at a secondary and tertiary academic centre. METHODS: Retrospectively we collated the clinical, endoscopic and histological features of all patients with SPS at St Vincent's public and private hospital in the last 3 years. Patients were identified by searching through 2 pathology databases...
September 16, 2017: World Journal of Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28953955/kras-and-braf-somatic-mutations-in-colonic-polyps-and-the-risk-of-metachronous-neoplasia
#10
Miriam Juárez, Cecilia Egoavil, María Rodríguez-Soler, Eva Hernández-Illán, Carla Guarinos, Araceli García-Martínez, Cristina Alenda, Mar Giner-Calabuig, Oscar Murcia, Carolina Mangas, Artemio Payá, José R Aparicio, Francisco A Ruiz, Juan Martínez, Juan A Casellas, José L Soto, Pedro Zapater, Rodrigo Jover
BACKGROUND & AIMS: High-risk features of colonic polyps are based on size, number, and pathologic characteristics. Surveillance colonoscopy is often recommended according to these findings. This study aimed to determine whether the molecular characteristics of polyps might provide information about the risk of metachronous advanced neoplasia. METHODOLOGY: We retrospectively included 308 patients with colonic polyps. A total of 995 polyps were collected and tested for somatic BRAF and KRAS mutations...
2017: PloS One
https://www.readbyqxmd.com/read/28940106/en-bloc-endoscopic-mucosal-resection-is-equally-effective-for-sessile-serrated-polyps-and-conventional-adenomas
#11
Amol Agarwal, Sidyarth Garimall, Frank I Scott, Nuzhat A Ahmad, Michael L Kochman, Gregory G Ginsberg, Vinay Chandrasekhara
BACKGROUND: Sessile serrated polyps (SSPs) are associated with higher rates of incomplete resection compared to conventional adenomas after traditional snare polypectomy. Outcomes after endoscopic mucosal resection (EMR) are less established. The aim of this study was to evaluate the rate of residual neoplasia at surveillance colonoscopy for SSPs compared to conventional adenomas ≥ 10 mm after en bloc EMR. METHODS: Retrospective cohort study of consecutive patients referred for EMR of a colonic lesion ≥ 10 mm from 2005 to 2013...
September 22, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28930817/cronkhite-canada-syndrome-associated-with-colon-cancer-metastatic-to-liver-a-case-report
#12
Jing Wang, Lei Zhao, Nina Ma, Juanjuan Che, Huihui Li, Bangwei Cao
RATIONALE: Cronkhite-Canada Syndrome (CCS) is an idiopathic, nonhereditary syndrome haracterized by gastrointestinal (GI) polyposis and ectodermal changes including alopecia, onychatrophia, and pigmentation. CCS colon polyps were previously considered to be benign neoplasms. However, serrated adenoma was reported to be associated with malignant neoplasms in some cases of gastric and colorectal carcinomas, and esophageal cancers. Although malignant colon and gastric cancer have been reported in CCS, reports of distant metastasis have been rare in CCS...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28929387/distinct-histopathological-characteristics-in-colorectal-submucosal-invasive-carcinoma-arising-in-sessile-serrated-adenoma-polyp-and-conventional-tubular-adenoma
#13
Takashi Murakami, Hiroyuki Mitomi, Takashi Yao, Tsuyoshi Saito, Tomoyoshi Shibuya, Naoto Sakamoto, Taro Osada, Sumio Watanabe
The histopathological characteristics of colorectal submucosal invasive carcinoma arising in sessile serrated adenoma/polyp (SSA/P), a rare malignant tumour, have not yet been fully elucidated. To investigate the features of such, we retrospectively analysed 40 submucosal invasive carcinomas with SSA/P (CA-SSA/P) and compared them to 129 cases of submucosal invasive carcinoma with conventional tubular adenoma (CA-AD). We additionally performed hMLH1 immunostaining. CA-SSA/Ps were significantly smaller than CA-ADs (P < 0...
September 19, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28927878/risk-of-metachronous-high-risk-adenomas-and-large-serrated-polyps-in-individuals-with-serrated-polyps-on-index-colonoscopy-data-from-the-new-hampshire-colonoscopy-registry
#14
Joseph C Anderson, Lynn F Butterly, Christina M Robinson, Julia E Weiss, Christopher Amos, Amitabh Srivastava
BACKGROUND & AIMS: Surveillance guidelines for serrated polyps (SPs) are based on limited data on longitudinal outcomes of patients. We used the New Hampshire Colonoscopy Registry to evaluate risk of clinically important metachronous lesions associated with SPs, detected during index colonoscopies. METHODS: We collected data from a population-based colonoscopy registry that has been collecting and analyzing data on colonoscopies across the state of New Hampshire since 2004, including rates of adenoma and serrated polyp detection...
September 16, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28927131/protein-expression-of-fragile-histidine-triad-and-cyclooxgenase-2-in-serrated-neoplasia-of-the-colorectum
#15
Akihiro Tamoto, Kazuo Yashima, Kohei Hosoda, Sohei Yamamoto, Soichiro Kawata, Yuichiro Ikebuchi, Kazuya Matsumoto, Koichiro Kawaguchi, Kenichi Harada, Yoshikazu Murawaki, Hajime Isomoto
The adenoma-carcinoma sequence (ACS) and the serrated pathway are two distinct developmental routes leading to the formation of colorectal carcinoma (CRC). However, the mechanism triggered by the serrated pathway remains unclear. Therefore, to clarify the molecular and clinicopathological characteristics of the serrated tumorigenic pathway, immunohistochemistry was used to examine the expression of Fragile Histidine Triad (FHIT), cyclooxygenase-2 (COX-2), MutL homolog 1 (MLH1), MutS protein homolog 2 (MSH2) and P53 in endoscopically resected samples of 62 serrated polyps...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28924598/carbon-dioxide-insufflation-is-associated-with-increased-serrated-polyp-detection-rate-when-compared-to-room-air-insufflation-during-screening-colonoscopy
#16
Michael Riverso, Yaseen B Perbtani, Jonathan J D Shuster, Joydeep Chakraborty, Tony S Brar, Mitali Agarwal, Han Zhang, Anand Gupte, Shailendra S Chauhan, Christopher E Forsmark, Peter V Draganov, Dennis Yang
BACKGROUND AND STUDY AIMS : Sessile serrated adenomas (SSA) and traditional serrated adenomas (TSA) have been increasingly recognized as precursors of colorectal cancer. The aim of this study was to compare the effect of carbon dioxide insufflation (CO 2 I) vs. room air insufflation (AI) on serrated polyp detection rate (SPDR) and to identify factors associated with SPDR. PATIENTS AND METHODS : Single-center retrospective cohort study of 2083 screening colonoscopies performed with AI (November 2011 through January 2013) or CO 2 I (February 2013 to June 2015)...
September 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28906425/impact-of-changeover-to-newer-endoscopic-systems-on-quality-and-efficiency-of-screening-and-surveillance-colonoscopy-equipment-or-endoscopist
#17
Manpreet Singh, Melody Sacatos, Loren Laine
GOALS: The goal of this study is to assess whether changeover to newer endoscopic systems impacts quality or efficiency, and quantify the relation between increased withdrawal time and detection rates of sessile serrated polyps (SSPDR) and adenomas (ADR) in real-world practice. STUDY: Beginning 2 months after new endoscopic systems were implemented at 2 endoscopy units, we included all outpatients undergoing screening/surveillance colonoscopy for 4 months. Outpatients during the same 4-month period 1 year earlier comprised the control group...
September 12, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28890813/endocuff-assisted-colonoscopy-significantly-increases-sessile-serrated-adenoma-detection-in-veterans
#18
Michael D Baek, Christian S Jackson, John Lunn, Chris Nguyen, Nicole K Shah, Steve Serrao, David Juma, Richard M Strong
BACKGROUND: Colorectal cancer (CRC) is the second most common cause of cancer related deaths in the United States. Colonoscopy is the gold standard for the detection of CRC. There are many colonoscopy quality measures and among these the adenoma detection rate (ADR) has demonstrated a significant impact in reducing mortality from CRC. The primary aim of our study was to compare ADR and distribution of polyp type in patients undergoing Endocuff-assisted colonoscopy (EAC) versus standard colonoscopy (SC) in a VA system...
August 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28865167/colorectal-surveillance-after-segmental-resection-for-young-onset-colorectal-cancer-is-there-evidence-for-extended-resection
#19
V N Kozak, M F Kalady, M M Gamaleldin, J Liang, J M Church
AIM: Although sporadic colorectal cancer (CRC) usually occurs in patients over 50, recent evidence suggests that the incidence is increasing in younger patients. Such patients are theoretically at high risk of metachronous neoplasia and may be candidates for extended, prophylactic, colectomy. This study aimed to define the risk of metachronous cancer/adenomas during follow-up of younger patients who underwent segmental colectomy for CRC. METHOD: A CRC database was used to identify patients aged less than 50 who underwent surgery for CRC between 1994 and 2010...
September 2, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28855108/squamoid-morules-in-the-pseudoinvasive-foci-of-colonic-polyp-morphologically-mimic-invasive-carcinoma
#20
Hee Eun Lee, Vishal S Chandan, Chung-Ta Lee, Tsung-Teh Wu
Colorectal adenomas can show focal squamous differentiation or squamoid morules. We describe histologic findings of squamoid morules in the pseudoinvasive foci of colorectal polyps mimicking invasive carcinoma. Five colonic polyps with squamoid morules in the pseudoinvasive foci were collected. Histologic review and immunostains for cytokeratin (CK) 5/6, p63, synaptophysin, and chromogranin were performed on cases with squamoid morules. Forty-seven consecutive colorectal polyps with pseudoinvasion, none of which showed squamoid morules by histology review, and their clinicopathologic features were compared with the cases containing squamoid morules...
August 27, 2017: Human Pathology
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