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https://www.readbyqxmd.com/read/29243845/fc%C3%AE%C2%B5r1%C3%AE-gene-polymorphism-shows-association-with-high-ige-and-anti-fc%C3%AE%C2%B5r1%C3%AE-in-chronic-rhinosinusitis-with-nasal-polyposis
#1
Sajad Ahmad Dar, Gargi Rai, Mohammad Ahmed Ansari, Naseem Akhter, Neelima Gupta, Sonal Sharma, Shafiul Haque, Vishnampettai Ganapathysubramanian Ramachandran, Mohd Wahid, M Rudramurthy Shivprakash, Arunaloke Chakrabarti, Shukla Das
Despite large number of investigations, the etiology of chronic rhinosinusitis (CRS) remains unclear. Several factors are likely involved in its onset. The genetic susceptibility of IgE-responsiveness likely caused by polymorphism(s) in high affinity receptor for IgE (FcεR1α) gene can help in understanding the pathophysiology of CRS with nasal polyposis (CRSwNP). A population-based case-control association analysis was conducted to assess the risk of CRSwNP conferred by single nucleotide polymorphisms (SNPs) in FcεR1α gene in a North Indian cohort...
December 15, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29239041/hereditary-and-familial-thyroid-tumours
#2
REVIEW
Julie Guilmette, Vania Nosé
The worldwide incidence of thyroid malignancies has been increasing rapidly. Sensitive imaging modalities and early detection of thyroid lesions have made thyroid cancers the most rapidly increasing cancers in the USA in 2017 (SEER Cancer Facts, 2017). Clinical awareness of potential risk factors, such as inherited thyroid cancers, has allowed earlier recognition of more vulnerable population clusters. Hereditary thyroid neoplasms arising from calcitonin-producing C cells are known as familial medullary thyroid carcinomas (FMTCs), and include well-documented syndromes such as multiple endocrine neoplasia IIA or IIB, and pure familial medullary thyroid carcinoma syndrome...
January 2018: Histopathology
https://www.readbyqxmd.com/read/29238040/il-3r-alpha-blockade-inhibits-tumor-endothelial-cell-derived-extracellular-vesicle-ev-mediated-vessel-formation-by-targeting-the-%C3%AE-catenin-pathway
#3
Giusy Lombardo, Maddalena Gili, Cristina Grange, Claudia Cavallari, Patrizia Dentelli, Gabriele Togliatto, Daniela Taverna, Giovanni Camussi, Maria Felice Brizzi
The proangiogenic cytokine Interleukin-3 (IL-3) is released by inflammatory cells in breast and ovarian cancer tissue microenvironments and also acts as an autocrine factor for human breast and kidney tumor-derived endothelial cells (TECs). We have previously shown that IL-3-treated endothelial cells (ECs) release extracellular vesicles (EVs), which serve as a paracrine mechanism for neighboring ECs, by transferring active molecules. The impact of an anti-IL-3R-alpha blocking antibody on the proangiogenic effect of EVs released from TECs (anti-IL-3R-EVs) has therefore been investigated in this study...
December 14, 2017: Oncogene
https://www.readbyqxmd.com/read/29237405/prevalence-and-characteristics-of-hereditary-non-polyposis-colorectal-cancer-hnpcc-syndrome-in-immigrant-asian-colorectal-cancer-patients
#4
Jasmine Lee, Yin-Yi Xiao, Yan Yu Sun, Jasminka Balderacchi, Bradley Clark, Jatin Desani, Vivek Kumar, Angela Saverimuthu, Khin Than Win, Yiwu Huang, Yiqing Xu
BACKGROUND: The prevalence of Hereditary Non-Polyposis Colorectal Cancer (HNPCC) is 2 to 5% in the Caucasian population. HNPCC is caused by genomic mutations in DNA mismatch repair genes (MMR), namely MLH1, MSH2, MSH6, PMS2, and EPCAM. A non-hereditary, acquired process of hypermethylation of the MLH1 promoter can also lead to silencing of MLH1 protein expression. Diagnosis of HNPCC in patients with colorectal and other related cancers is important in the clinical treatment and surveillance of related cancers...
December 13, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29236276/5-ht7-receptors-are-over-expressed-in-patients-with-nasal-polyps
#5
Muhammed Yayla, Zekai Halici, Duygu Kose, Arzu Tatar, Mustafa Sitki Gozeler
Nasal polyposis (NP) is an inflammatory disease of the paranasal sinuses and nasal cavity. The primary purpose of our study is to determine the expression of 5-HT7 receptors both in nasal polyps and in healthy tissue in the nasal cavity. The subsequent aim is to compare the expression of 5-HT7 receptors in patients with NP and in inferior turbinate tissue (control). The study included 60 participants (40 with NP and 20 controls) aged 35 to 62 years. Nasal polyp samples were collected from all patients and relative 5-HT7 receptor expression analyses were performed...
December 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/29230281/colon-adenocarcinoma-after-jejunoileal-bypass-for-morbid-obesity
#6
Lee Morris, Ilimbek Beketaev, Roberto Barrios, Patrick Reardon
Jejunoileal bypass (JIB) was developed as a surgical treatment for morbid obesity in the early 1950s. However, this procedure is now known to be associated with multiple metabolic complications and has subsequently been abandoned as a viable bariatric procedure. Some of these known complications include renal stone formation, liver failure, migratory arthritis, fat-soluble deficiencies, blind-loop syndrome and severe diarrhea. Additionally, there have been animal models suggesting colon dysplasia after JIB...
November 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29229196/impact-of-allergy-on-phenotypic-and-endotypic-profiles-of-nasal-polyposis
#7
G Mortuaire, I Gengler, M Balden, M Capron, G Lefèvre
OBJECTIVES: To assess the impact of allergy on clinical presentations (phenotypes) and inflammatory patterns (endotypes) of chronic rhinosinusitis with nasal polyps (CRSwNP). METHODS: A single-center prospective study was conducted over an 18-month period. Fifty-seven patients with refractory CRSwNP were included. The diagnosis of allergy was based on concordant skin prick tests and symptoms. Phenotypes were determined on symptom severity score, polyp size classification and Lund-Mackay CT staging...
December 8, 2017: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/29221194/altered-microrna-profiles-during-early-colon-adenoma-progression-in-a-porcine-model-of-familial-adenomatous-polyposis
#8
Monika Stachowiak, Tatiana Flisikowska, Stefan Bauersachs, Carolin Perleberg, Hubert Pausch, Marek Switonski, Alexander Kind, Dieter Saur, Angelika Schnieke, Krzysztof Flisikowski
MicroRNAs are dysregulated in various cancers including colorectal cancer, and are potential useful biomarkers of disease development. We used next generation sequencing to investigate miRNA expression profiles in low- and high-grade intraepithelial dysplastic polyps from pigs carrying a mutation in the adenomatous polyposis coli tumour suppressor (APC1311 , orthologous to human APC1309 ) that model an inherited predisposition to colorectal cancer, familial adenomatous polyposis. We identified several miRNAs and their isomiRs significantly (P < 0...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29217947/coexistence-of-peripheral-spondyloarthritis-and-familial-adenomatous-polyposis-a-rare-case-report-with-treatment-contradictions-and-review-of-the-literature
#9
Berna Urkmez, Muge Kepekci, Sevde Ozer Posul, Aylin Rezvani
Background: The coexistence of familial adenomatous polyposis and spondyloarthritis is rarely defined in literature. The primary aim of this presentation is to report a development of peripheral arthritis in 3 years following colon surgery with the diagnosis of familial adenomatous polyposis (FAP). The secondary aim is to discuss the challenge of in treatment of refractory arthritis, which needs to be treated with biologics. However, it is not yet known well about their safety on patients who have risks for cancer development...
July 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29216840/over-the-scope-clip-pre-mounted-onto-a-double-balloon-enteroscope-for-fast-and-successful-closure-of-post-emr-jejunal-perforation-case-report
#10
Flaminia Purchiaroni, Takeshi Nakajima, Taku Sakamoto, Seiichiro Abe, Yutaka Saito
BACKGROUND: Familial adenomatous polyposis (FAP) is a rare, autosomal dominant disease clinically characterized by the early onset of many adenomatous polyps throughout the colon, which turn into colon cancer, if left untreated. In FAP patients, polyps can also occur in the upper gastrointestinal (GI) tract, especially in the duodenum. Adenomas beyond duodenum are rare and mostly located in the proximal jejunum and distal ileum. The management of such polyps can be either surgical or endoscopic, depending on the features of the polyp, Spigelman stage and patient's clinical conditions...
December 8, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/29215473/duodenal-adenomas-in-patients-with-multiple-colorectal-adenomas-without-germline-apc-or-mutyh-mutations
#11
Frank G J Kallenberg, Andrew Latchford, Nikki C Lips, Cora M Aalfs, Barbara A J Bastiaansen, Susan K Clark, Evelien Dekker
BACKGROUND: Patients with genetic adenomatous polyposis syndromes have an increased risk for duodenal cancer, and clear surveillance recommendations exist for this group. However, limited data are available on the duodenal phenotype of patients with multiple colorectal adenomas (10-99) without a germline APC or MUTYH mutation. OBJECTIVE: We aimed to assess the frequency, extent, and progression of duodenal adenomas in patients with multiple colorectal adenomas without a germline APC or MUTYH mutation...
January 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29214756/serum-cytokine-profile-in-patients-with-chronic-rhinosinusitis-with-nasal-polyposis-infected-by-aspergillus-flavus
#12
Gargi Rai, Mohammad Ahmad Ansari, Sajad Ahmad Dar, Shyama Datt, Neelima Gupta, Sonal Sharma, Shafiul Haque, Vishnampettai Ganapathysubramanian Ramachandran, Arpeeta Mazumdar, Shivprakash Rudramurthy, Arunaloke Chakrabarti, Shukla Das
BACKGROUND: Fungi, especially Aspergillus flavus, can cause chronic rhinosinusitis with nasal polyposis and modulate host innate immune components. The objective of this study was to examine the serum levels of T helper (Th) cell subset Th1, Th2, and Th17 cytokines and total IgE in patients having chronic rhinosinusitis with nasal polyposis and Aspergillus flavus infection. METHODS: A case-control study including 40 patients with chronic rhinosinusitis with nasal polyposis and 20 healthy controls was conducted...
March 2018: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/29213343/exome-sequencing-characterizes-the-somatic-mutation-spectrum-of-early-serrated-lesions-in-a-patient-with-serrated-polyposis-syndrome-sps
#13
Sukanya Horpaopan, Jutta Kirfel, Sophia Peters, Michael Kloth, Robert Hüneburg, Janine Altmüller, Dmitriy Drichel, Margarete Odenthal, Glen Kristiansen, Christian Strassburg, Jacob Nattermann, Per Hoffmann, Peter Nürnberg, Reinhard Büttner, Holger Thiele, Philip Kahl, Isabel Spier, Stefan Aretz
Background: Serrated or Hyperplastic Polyposis Syndrome (SPS, HPS) is a yet poorly defined colorectal cancer (CRC) predisposition characterised by the occurrence of multiple and/or large serrated polyps throughout the colon. A serrated polyp-CRC sequence (serrated pathway) of CRC formation has been postulated, however, to date only few molecular signatures of serrated neoplasia (BRAF, KRAS, RNF43 mutations, CpG Island Methylation, MSI) have been described in a subset of SPS patients and neither the etiology of the syndrome nor the distinct genetic alterations during tumorigenesis have been identified...
2017: Hereditary Cancer in Clinical Practice
https://www.readbyqxmd.com/read/29210519/air-pollutants-may-be-environmental-risk-factors-in-chronic-rhinosinusitis-disease-progression
#14
Leila J Mady, Hannah L Schwarzbach, John A Moore, Robert M Boudreau, Thomas J Willson, Stella E Lee
BACKGROUND: Little is known about the role of environmental exposures in the pathophysiology of chronic rhinosinusitis (CRS). In this study, we measured the impact of air pollutants (particulate matter 2.5 [PM2.5 ] and black carbon [BC]) on CRS with nasal polyposis (CRSwNP) and CRS without nasal polyposis (CRSsNP). METHODS: Spatial modeling from pollutant monitoring sites was used to estimate exposures surrounding residences for patients meeting inclusion criteria (total patients, n = 234; CRSsNP, n = 96; CRSwNP, n = 138)...
December 6, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29207718/an-alpha-fetoprotein-producing-gastric-tumor-with-yolk-sac-hepatoid-and-papillary-adenocarcinoma-components
#15
Archana Lakshmanan, Ann Kurian, Annapurneswari Subramanyan, Ayyappan Srinivasan
Alpha Fetoprotein (AFP) producing gastric carcinomas are very rare and have unique clinicopathological features and an extremely poor prognosis. Here, we report a case of AFP producing gastric carcinoma with three distinct histomorphologic patterns such as yolk sac like, hepatoid, tubular and papillary adenocarcinoma components. The uniqueness of this case is absence of metastases and associated findings such as fundic gland polyposis with varying degrees of dysplasia, gastric and duodenal well differentiated neuroendocrine tumour and rectal ganglioneuroma...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29206907/a-novel-bioactive-derivative-of-eicosapentaenoic-acid-epa-suppresses-intestinal-tumor-development-in-apc%C3%AE-14-mice
#16
Masako Nakanishi, Matthew P Hanley, Ruochen Zha, Yuichi Igarashi, Mark A Hull, Gary Mathias, Frank Sciavolino, James J Grady, Daniel W Rosenberg
Familial adenomatous polyposis (FAP) is a genetic disorder characterized by the development of hundreds of polyps throughout the colon. Without prophylactic colectomy, most individuals with FAP develop colorectal cancer at an early age. Treatment with eicosapentaenoic acid (EPA) in the free fatty acid form (EPA-FFA) has been shown to reduce polyp burden in FAP patients. Since high-purity EPA-FFA is subject to rapid oxidation, a stable form of EPA compound has been developed in the form of magnesium l-lysinate bis-eicosapentaenoate (TP-252)...
December 1, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/29203224/gastrointestinal-mantle-cell-lymphoma-presenting-as-lymphomatous-polyposis
#17
Galen Leung, Jela Bandovic, Jonathan M Buscaglia
No abstract text is available yet for this article.
December 1, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29202677/cronkhite-canada-syndrome-causing-pouch-outlet-obstruction-5-years-after-roux-en-y-gastric-bypass
#18
Ben Gys, Joren Mertens, Martin Ruppert, Guy Hubens
OBJECTIVE: We present the case of a 57-year-old man with a history of Roux-en-Y gastric bypass (RYGB) and colonic polyps who presented with an upper gastrointestinal obstruction based on massive stomach polyposis in the pouch. METHODS: Two months prior to this acute admission, he had undergone resection of the gastric remnant due to massive refractory intraluminal bleeding from a polypoid mass. Ten years earlier, right colectomy was performed due to hypertrophic polyposis unsuitable for endoscopic polypectomy...
December 5, 2017: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/29202476/stromal-lkb1-deficiency-leads-to-gastrointestinal-tumorigenesis-involving-the-il-11-jak-stat3-pathway
#19
Saara Ollila, Eva Domènech-Moreno, Kaisa Laajanen, Iris Pl Wong, Sushil Tripathi, Nalle Pentinmikko, Yajing Gao, Yan Yan, Elina H Niemelä, Timothy C Wang, Benoit Viollet, Gustavo Leone, Pekka Katajisto, Kari Vaahtomeri, Tomi P Mäkelä
Germline mutations in the gene encoding tumor suppressor kinase LKB1 lead to gastrointestinal tumorigenesis in Peutz-Jeghers syndrome (PJS) patients and mouse models; however, the cell types and signaling pathways underlying tumor formation are unknown. Here, we demonstrated that mesenchymal progenitor- or stromal fibroblast-specific deletion of Lkb1 results in fully penetrant polyposis in mice. Lineage tracing and immunohistochemical analyses revealed clonal expansion of Lkb1-deficient myofibroblast-like cell foci in the tumor stroma...
December 4, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29193105/correlations-between-cystic-fibrosis-genotype-and-sinus-disease-severity-in-chronic-rhinosinusitis
#20
Waleed M Abuzeid, Changeun Song, Judd H Fastenberg, Christina H Fang, Noel Ayoub, Elina Jerschow, Paul K Mohabir, Peter H Hwang
OBJECTIVE: Cystic fibrosis (CF) patients commonly develop chronic rhinosinusitis (CRS). The impact of the most common cystic fibrosis transmembrane conductance regulator (CFTR) mutation, F508del, on the severity of sinonasal disease remains inconclusive. The objective of this study is to evaluate the impact of CFTR genotype functional classification on sinonasal disease severity in patients with CRS. METHODS: Retrospective chart review of patients with CF who underwent endoscopic sinus surgery for chronic rhinosinusitis from 1998 to 2015...
November 29, 2017: Laryngoscope
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