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https://www.readbyqxmd.com/read/29673457/-mir-182-promotes-cell-proliferation-of-cervical-cancer-cells-by-targeting-adenomatous-polyposis-coli-apc-gene
#1
Pei Li, Jing Hu, Ying Zhang, Jianping Li, Yunzhi Dang, Rui Zhang, Lichun Wei, Mei Shi
Objective To investigate the role and mechanism of microRNA-182 (miR-182) in the proliferation of cervical cancer cells. Methods With liposome-mediated transient transfection method, the level of miR-182 in HeLa and SiHa cells was increased or decreased. CCK-8 assay and colony formation assay were used to observe the effect of miR-182 on the proliferation of cervical cancer cells. Using bioinformatics predictions, real-time quantitative PCR, and dual luciferase reporter assay, we clarified the role of miR-182 in posttranscriptional regulation of adenomatous polyposis coli (APC) gene and its effect on the downstream molecules (c-Myc and cyclin D1) of Wnt singling pathway...
February 2018: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/29672847/loss-of-n-wasp-drives-early-progression-in-an-apc-model-of-intestinal-tumourigenesis
#2
Hayley T Morris, Loic Fort, Heather J Spence, Rachana Patel, David F Vincent, James H Park, Scott B Snapper, Francis A Carey, Owen J Sansom, Laura M Machesky
N-WASP (WASL) is a widely expressed cytoskeletal signalling and scaffold protein also implicated in regulation of Wnt signalling and homeostatic maintenance of skin epithelial architecture. N-WASP mediates invasion of cancer cells in vitro and its depletion reduces invasion and metastatic dissemination of breast cancer. Given this role in cancer invasion and universal expression in the gastrointestinal tract, we explored a role for N-WASP in the initiation and progression of colorectal cancer. While deletion of N-wasp is not detectably harmful in the murine intestinal tract, numbers of Paneth cells increased, indicating potential changes in the stem cell niche and migration up the crypt-villus axis was enhanced...
April 19, 2018: Journal of Pathology
https://www.readbyqxmd.com/read/29671617/oxazole-and-thiazole-analogs-of-sulindac-for-cancer-prevention
#3
Bini Mathew, Judith V Hobrath, Michele C Connelly, R Kiplin Guy, Robert C Reynolds
AIM: Experimental and epidemiological studies and clinical trials suggest that nonsteroidal anti-inflammatory drugs possess antitumor potential. Sulindac, a widely used nonsteroidal anti-inflammatory drug, can prevent adenomatous colorectal polyps and colon cancer, especially in patients with familial adenomatous polyposis. Sulindac sulfide amide (SSA) is an amide-linked sulindac sulfide analog that showed in vivo antitumor activity in a human colon tumor xenograft model. Results/methodology: A new analog series with heterocyclic rings such as oxazole or thiazole at the C-2 position of sulindac was prepared and screened against prostate, colon and breast cancer cell lines to probe the effect of these novel substitutions on the activity of sulindac analogs...
April 19, 2018: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/29670184/wogonin-attenuates-nasal-polyp-formation-by-inducing-eosinophil-apoptosis-through-hif-1%C3%AE-and-survivin-suppression
#4
Roza Khalmuratova, Mingyu Lee, Ji-Hun Mo, YunJae Jung, Jong-Wan Park, Hyun-Woo Shin
Chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) is an inflammatory sinonasal disorder characterized by eosinophilic inflammation and T-helper 2 skewing. Eosinophil accumulation in sinonasal mucosa comprises a major feature of CRSwNP. The study aimed to investigate the effect of the flavone wogonin in nasal polyposis by assessing its ability to induce eosinophil apoptosis in vitro and attenuate eosinophilic CRSwNP in mice. Double immunofluorescence, immunohistochemistry, flow cytometry, and immunoblotting were performed to evaluate hypoxia-inducible factor (HIF)-1α, survivin, and apoptotic markers in the human eosinophilic EoL-1 cell line or sinonasal tissues from patients with CRS with or without NPs...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29663106/prevalence-of-thyroid-diseases-in-familial-adenomatous-polyposis-a-systematic-review-and-meta-analysis
#5
Jirat Chenbhanich, Amporn Atsawarungruangkit, Sira Korpaisarn, Tanit Phupitakphol, Soravis Osataphan, Prasit Phowthongkum
Thyroid cancer (TC) is a known extra-intestinal manifestation and contributes to the mortality and morbidity in patients with familial adenomatous polyposis (FAP). Its exact prevalence is not well established and recent studies have shown an increasing number of TC in this patient population. The prevalence of benign thyroid masses and endocrinologic thyroid disorders are also poorly described. We conducted a systematic review and meta-analysis by using a random-effects model to characterize TC and estimated the prevalence of thyroid diseases in FAP patients...
April 16, 2018: Familial Cancer
https://www.readbyqxmd.com/read/29661611/nasal-polyposis-or-chronic-olfactory-rhinitis
#6
R Jankowski, C Rumeau, P Gallet, D T Nguyen
The concept of chronic rhinosinusitis with or without polyps is founded on the structural and functional unicity of the pituitary mucosa and its united response to environmental aggression by allergens, viruses, bacteria, pollution, etc. The present review sets this concept against the evo-devo three-nose theory, in which nasal polyposis is distinguished as specific to the olfactory nose and in particular to the non-olfactory mucosa of the ethmoid, which is considered to be not a sinus but rather the skull-base bone harboring the olfactory mucosa...
April 13, 2018: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/29650970/crosstalk-between-gut-microbiota-and-sirtuin-3-in-colonic-inflammation-and-tumorigenesis
#7
Yong Zhang, Xiao-Lan Wang, Min Zhou, Chao Kang, He-Dong Lang, Meng-Ting Chen, Suo-Cheng Hui, Bin Wang, Man-Tian Mi
Colorectal cancer (CRC) is a disease involving a variety of genetic and environmental factors. Sirtuin-3 (Sirt3) is expressed at a low level in cancer tissues of CRC, but it is unclear how Sirt3 modulates colonic tumorigenesis. In this study, we found that gut microbiota play a central role in the resistance to CRC tumor formation in wild-type (WT) mice through APC (Adenomatous Polyposis Coli)-mutant mouse microbiota transfer via Wnt signaling. We also found that Sirt3-deficient mice were hypersusceptible to colonic inflammation and tumor development through altered intestinal integrity and p38 signaling, respectively...
April 13, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29650924/-endoscopy-assisted-partial-duodenal-resection-for-duodenal-adenoma-in-a-patient-with-familial-adenomatous-polyposis
#8
Tomoaki Hirashima, Shinobu Ohnuma, Hideaki Karasawa, Kazuhiro Watanabe, Hirofumi Imoto, Takeshi Aoki, Katsuyoshi Kudoh, Naoki Tanaka, Munenori Nagao, Hiroaki Musha, Fuyuhiko Motoi, Takashi Kamei, Takeshi Naitoh, Michiaki Unno
We here report a case of endoscopy-assisted partial duodenal resection for duodenal adenoma in a patient with familial adenomatous polyposis(FAP). A male underwent total proctocolectomy with ileal pouch anal anastomosis in 1997. Since 2004, duodenal adenomas occurred and the atypical grade of adenoma was gradually aggravated. Therefore, he underwent endoscopy-assisted partial duodenal resection in 2013. The pathological finding of the specimen showed well-differentiated tubular adenocarcinoma(pM, ly0, v0). No recurrence has been observed at 4 years after the operation...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29643736/desmoid-fibromatosis-of-the-lower-abdominal-wall-in-irrua-nigeria
#9
Oluwafemi Olasupo Awe, Sylvester Eluehike
Desmoid fibromatosis (desmoid tumors) is rare tumors. It can occur as intra-abdominal, extraabdominal, or abdominal wall tumor depending on the site. The abdominal wall type is usually sporadic, but few have been associated with familial adenomatous polyposis. They are commonly seen in young females who are pregnant with a history of the previous cesarean section scar or within the 1st year of the last childbirth. There is an association between this tumor, presence of estrogen receptors, and abdominal trauma...
January 2018: Nigerian Journal of Surgery: Official Publication of the Nigerian Surgical Research Society
https://www.readbyqxmd.com/read/29627492/gastric-adenomas-in-familial-adenomatous-polyposis-you-only-see-them-when-you-know-what-to-look-for
#10
Victorine H Roos, Barbara A J Bastiaansen, Evelien Dekker
No abstract text is available yet for this article.
April 5, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29627174/short-term-outcomes-in-children-undergoing-restorative-proctocolectomy-with-ileal-pouch-anal-anastomosis
#11
Katerina Dukleska, Loren Berman, Allison A Aka, Charles D Vinocur, Erin A Teeple
INTRODUCTION: Patients with familial adenomatous polyposis (FAP) and ulcerative colitis (UC) commonly undergo restorative proctocolectomy with ileal-pouch anal anastomosis (RP-IPAA). We sought to describe patient characteristics and postoperative outcomes in this patient population. METHODS: Using the National Surgical Quality Improvement Program-Pediatric Participant Use Files from 2012 to 2015, children who were 6-18years old who underwent RP-IPAA for FAP or UC were identified...
March 7, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29625668/is-there-a-link-between-nasal-polyposis-and-increased-risk-for-sinonasal-malignancy
#12
Deena Pourang, Michael Batech, Kian Karimi, Javed Sheikh, Shefali Samant
No abstract text is available yet for this article.
April 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29624892/antibiotic-mediated-bacteriome-depletion-in-apc-min-mice-is-associated-with-reduction-in-mucus-producing-goblet-cells-and-increased-colorectal-cancer-progression
#13
Kamaljeet Kaur, Arpit Saxena, Irina Debnath, Jacqueline L O'Brien, Nadim J Ajami, Thomas A Auchtung, Joseph F Petrosino, Alexander-Jacques Sougiannis, Sarah Depaep, Alexander Chumanevich, Phani M Gummadidala, Mayomi H Omebeyinje, Sourav Banerjee, Ioulia Chatzistamou, Paramita Chakraborty, Raja Fayad, Franklin G Berger, James A Carson, Anindya Chanda
Recent epidemiological evidence suggests that exposure to antibiotics in early-to-middle adulthood is associated with an increased risk of colorectal adenoma. However, mechanistic studies in established preclinical cancer to examine these claims are extremely limited. Therefore, we investigated the effect of long-term exposure of an antibiotic cocktail composed of Vancomycin, Neomycin, and Streptomycin, on tumor development and progression in the ApcMin/+ mouse, an established genetic model for familial adenomatous polyposis...
April 6, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29619395/sirolimus-in-refractory-cronkhite-canada-syndrome-and-focus-on-standard-treatment
#14
Catherine Langevin, Hugo Chapdelaine, Jean-Maxime Picard, Pierre Poitras, Raymond Leduc
Cronkhite-Canada syndrome is a rare syndrome consisting of extensive gastrointestinal polyposis and ectodermal changes including cutaneous hyperpigmentation, alopecia, and onychodystrophy. We report the case of a 45-year-old Caucasian male patient who failed multiple treatments over 2 years including steroids, azathioprine, adalimumab, and cyclosporine. He had recurrent and prolonged hospitalizations because of diarrhea, abdominal pain, weight loss, and malnutrition. Sirolimus was initiated with a significant clinical and endoscopic benefit apparent within, respectively, 2 and 8 weeks...
January 2018: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/29617376/brain-tumor-promotes-axon-growth-across-the-midline-through-interactions-with-the-microtubule-stabilizing-protein-apc2
#15
Elise Arbeille, Greg J Bashaw
Commissural axons must cross the midline to establish reciprocal connections between the two sides of the body. This process is highly conserved between invertebrates and vertebrates and depends on guidance cues and their receptors to instruct axon trajectories. The DCC family receptor Frazzled (Fra) signals chemoattraction and promotes midline crossing in response to its ligand Netrin. However, in Netrin or fra mutants, the loss of crossing is incomplete, suggesting the existence of additional pathways. Here, we identify Brain Tumor (Brat), a tripartite motif protein, as a new regulator of midline crossing in the Drosophila CNS...
April 4, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29615557/wingless-wnt-signaling-in-intestinal-development-homeostasis-regeneration-and-tumorigenesis-a-drosophila-perspective
#16
REVIEW
Ai Tian, Hassina Benchabane, Yashi Ahmed
In mammals, the Wnt/β-catenin signal transduction pathway regulates intestinal stem cell maintenance and proliferation, whereas Wnt pathway hyperactivation, resulting primarily from the inactivation of the tumor suppressor Adenomatous polyposis coli (APC), triggers the development of the vast majority of colorectal cancers. The Drosophila adult gut has recently emerged as a powerful model to elucidate the mechanisms by which Wingless/Wnt signaling regulates intestinal development, homeostasis, regeneration, and tumorigenesis...
March 28, 2018: Journal of Developmental Biology
https://www.readbyqxmd.com/read/29611776/last-station-in-the-eosinophilic-asthma-with-chronic-rhinosinusitis-and-or-nasal-polyposis-march-eosinophilic-asthma-with-radiological-findings-associated-with-blood-eosinophilia
#17
Insu Yılmaz, Sakine Nazik Bahçecioğlu, Murat Türk, Nuri Tutar, Fatma Sema Oymak, İnci Gülmez
OBJECTIVE: Eosinophilic asthma with chronic rhinosinusitis and/or nasal polyposis (EA-CRS/NP) is a subphenotype of adult-onset eosinophilic asthma. Blood eosinophil levels are shown to be highly elevated in patients with EA-CRS/NP and have potential for tissue infiltration. We aimed to demonstrate the clinical features of the patients who have a blood eosinophil level above 10% and have thorax computed tomography findings due to blood eosinophilia. METHODS: Patients who were followed up in our clinic between 2012 and 2017 were retrospectively evaluated...
April 3, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29611440/new-biologics-for-allergic-diseases
#18
Laurie A Manka, Michael E Wechsler
Allergic conditions such as asthma and atopic dermatitis have a high prevalence but represent a heterogeneous group of diseases despite similar clinical presentation and underlying pathophysiology. A better understanding of the phenotypes and endotypes of these diseases has driven rapid development of biologic medications targeting many steps of the inflammatory pathways. Areas Covered: There are 2 major inflammatory pathways that drive allergic diseases: Type-2 (Th-2) inflammation and non-type 2 inflammation...
April 3, 2018: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/29610499/phenotypic-variability-of-mutyh-associated-polyposis-in-monozygotic-twins-and-endoscopic-resection-of-a-giant-polyp-in-pregnancy
#19
Markus Casper, Isabel Spier, Robert Holz, Stefan Aretz, Frank Lammert
No abstract text is available yet for this article.
April 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29601150/comparing-the-efficacy-of-silastic-and-gloved-merocel-middle-meatal-spacers-for-functional-endoscopic-sinus-surgery-a-randomized-controlled-trial
#20
Jamil Manji, Al-Rahim R Habib, Luis Macias-Valle, Andres Finkelstein, Saad Alsaleh, Anali Dadgostar, Fahad Al-Asousi, Christopher Okpaleke, Amin R Javer
BACKGROUND: Spacers are inserted into the middle meatal space (MMS) following functional endoscopic sinus surgery (FESS) to prevent lateralization of the middle turbinate, scarring, and synechiae. Our objective was to determine if the incidence of postoperative synechiae, facial pain/discomfort, pain during spacer removal, scarring, and discharge differed between nasal cavities receiving Silastic or gloved-Merocel (GM) spacers following FESS. METHODS: A double-blind, randomized controlled trial (RCT) was conducted in adults requiring bilateral FESS for chronic rhinosinusitis (CRS) ± nasal polyposis...
March 30, 2018: International Forum of Allergy & Rhinology
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