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https://www.readbyqxmd.com/read/29027468/serrated-polyposis-syndrome-associated-with-long-standing-inflammatory-bowel-disease
#1
Jesús Castro, Miriam Cuatrecasas, Francesc Balaguer, Elena Ricart, María Pellisé
Inflammatory bowel disease (IBD) patients are at an increased risk of developing colorectal cancer (CRC), which is thought to develop via the adenoma-carcinoma pathway. Since the discovery of the serrated carcinogenesis pathway and serrated polyposis syndrome (SPS), the incidence of carcinomas arising from serrated lesions in IBD patients has increased. We report three cases of long-standing IBD patients with associated serrated polyposis syndrome. At present, the pathophysiology of serrated lesions in IBD patients is not fully understood and there is a lack of strong evidence to confirm whether the manifestation of both conditions represents an increased risk of developing cancer...
October 13, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29027306/fenton-reaction-induced-renal-carcinogenesis-in-mutyh-deficient-mice-exhibits-less-chromosomal-aberrations-than-the-rat-model
#2
Guang Hua Li, Shinya Akatsuka, Shan Hwu Chew, Li Jiang, Takahiro Nishiyama, Akihiko Sakamoto, Takashi Takahashi, Mitsuru Futakuchi, Hiromu Suzuki, Kunihiko Sakumi, Yusaku Nakabeppu, Shinya Toyokuni
Oxidative stress including iron excess has been associated with carcinogenesis. The level of 8-oxoguanine, a major oxidatively modified base in DNA, is maintained very low by three distinct enzymes, encoded by OGG1, MUTYH and MTH1. Germline biallelic inactivation of MUTYH represents a familial cancer syndrome called MUTYH-associated polyposis. Here, we used Mutyh-deficient mice to evaluate renal carcinogenesis induced by ferric nitrilotriacetate (Fe-NTA). Although the C57BL/6 background is cancer-resistant, a repeated intraperitoneal administration of Fe-NTA induced a high incidence of renal cell carcinoma (RCC; 26...
October 13, 2017: Pathology International
https://www.readbyqxmd.com/read/29026081/extracellular-matrix-stiffness-and-cell-contractility-control-rna-localization-to-promote-cell-migration
#3
Tianhong Wang, Susan Hamilla, Maggie Cam, Helim Aranda-Espinoza, Stavroula Mili
Numerous RNAs are enriched within cellular protrusions, but the underlying mechanisms are largely unknown. We had shown that the APC (adenomatous polyposis coli) protein controls localization of some RNAs at protrusions. Here, using protrusion-isolation schemes and RNA-Seq, we find that RNAs localized in protrusions of migrating fibroblasts can be distinguished in two groups, which are differentially enriched in distinct types of protrusions, and are additionally differentially dependent on APC. APC-dependent RNAs become enriched in high-contractility protrusions and, accordingly, their localization is promoted by increasing stiffness of the extracellular matrix...
October 12, 2017: Nature Communications
https://www.readbyqxmd.com/read/29022381/effects-of-probiotic-bacteria-on-mucosal-polyamines-levels-in-dogs-with-ibd-and-colonic-polyps-a-preliminary-study
#4
G Rossi, M Cerquetella, S Scarpona, G Pengo, K Fettucciari, G Bassotti, A E Jergens, J S Suchodolski
Spermine (SPM) and its precursor putrescine (PUT), regulated by ornithine decarboxylase (ODC) and diamino-oxidase (DAO), are polyamines required for cell growth and proliferation. Only a few studies have investigated the anti-inflammatory and tumour inhibitory properties of probiotics on mucosal polyamine levels. We investigated the effects of a high concentration multistrain probiotic for human use on colonic polyamine biosynthesis in dogs. Histological sections (inflammatory bowel disease, n=10; polyposis, n=5) were assessed after receiving 112 to 225×10(9) lyophilised bacteria daily for 60 days at baseline (T0) and 30 days after treatment end (T90)...
October 12, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/29021452/a-case-of-familial-adenomatous-polyposis-with-multiple-helicobacter-negative-early-gastric-cancers-treated-by-endoscopic-submucosal-dissection
#5
Katsuki Yaguchi, Makomo Makazu, Kingo Hirasawa, Makoto Sugimori, Ryosuke Kobayashi, Chiko Sato, Ryosuke Ikeda, Takehide Fukuchi, Yasuaki Ishii, Hiroaki Kaneko, Wataru Shibata, Shoji Yamanaka, Yoshiaki Inayama, Shin Maeda
Stomach cancer rarely develops in patients with familial adenomatous polyposis (FAP), and Helicobacter pylori infection may increase the risk of FAP-related gastric cancer. We describe the case of a 64-year-old woman who developed multiple synchronous early gastric cancers without H. pylori infection. Nine cancer lesions were successfully treated by endoscopic submucosal dissection. An immunohistochemical analysis revealed that the tumors were positive for MUC2, MUC6, and CDX2, but negative for MUC5AC, suggesting that the tumors were gastrointestinal mixed type...
October 11, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29018504/hmgb1-in-the-pathogenesis-of-nasal-inflammatory-diseases-and-its-inhibition-as-new-therapeutic-approach-a-review-from-the-literature
#6
REVIEW
Luisa Maria Bellussi, Serena Cocca, Giulio Cesare Passali, Desideri Passali
Introduction  This study is a systematic review on recent developments about the importance of HMGB1 protein in the pathogenesis of rhino-sinusal inflammatory diseases. We also report data on the use of 18-β-glycyrrhetic acid (GA), which has been shown able to inhibit the pro-inflammatory activities of HMGB1, in young patients affected by allergic rhinitis and complaining of nasal obstruction as main symptom. Objectives  The objective of this study was to review the literature to demonstrate the importance of HMGB1 in the pathogenesis of nasal inflammatory disorders and understand whether the inhibition of this protein may be an efficacious and innovative therapeutic strategy for patients with rhino-sinusal inflammation...
October 2017: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/28991077/surveillance-of-duodenal-polyposis-in-familial-adenomatous-polyposis-should-the-spigelman-score-be-modified
#7
EDITORIAL
Isabelle Sourrouille, Jérémie H Lefèvre, Conor Shields, Chrystelle Colas, Jerôme Bellanger, Benoît Desaint, Francois Paye, Emmanuel Tiret, Yann Parc
BACKGROUND: Duodenal polyposis is a manifestation of adenomatous polyposis that predisposes to duodenal or ampullary adenocarcinoma. Duodenal polyposis is monitored by upper GI endoscopies and may require iterative resections and prophylactic radical surgical treatment when malignancy is threatening. OBJECTIVE: The purpose of this study was to evaluate severity scoring for surveillance and treatment in a large series of duodenal polyposis. DESIGN: From 1982 to 2014, every patient surveyed by upper GI endoscopies for duodenal polyposis was included...
November 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28991073/spigelman-scoring-system-underestimates-the-risk-of-ampullary-and-duodenal-carcinoma-in-patients-with-familial-adenomatous-polyposis-with-duodenal-polyposis
#8
Joshua Tierney, Gary C Vitale
No abstract text is available yet for this article.
November 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28991072/surveillance-of-duodenal-polyposis-in-familial-adenomatous-polyposis-should-the-spigelman-score-be-modified
#9
Susan K Clark, Andrew Latchford
No abstract text is available yet for this article.
November 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28990423/dupilumab-for-the-treatment-of-asthma
#10
Corrado Pelaia, Alessandro Vatrella, Luca Gallelli, Rosa Terracciano, Paolo Navalesi, Rosario Maselli, Girolamo Pelaia
Dupilumab is a fully human IgG4 monoclonal antibody directed against the α subunit of the interleukin (IL)-4 receptor (IL-4Rα). Since the activation of IL-4Rα is utilized by both IL-4 and IL-13 to mediate their pathophysiological effects, dupilumab behaves as a dual antagonist of these two sister cytokines, which blocks IL-4/IL-13-dependent signal transduction. Areas covered: Herein, the authors review the cellular and molecular pathways activated by IL-4 and IL-13, which are relevant to asthma pathobiology...
October 8, 2017: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/28990012/impact-of-endoscopic-sinus-surgery-on-otologic-symptoms-associated-with-chronic-rhinosinusitis
#11
Neville W Teo, Jess C Mace, Timothy L Smith, Peter H Hwang
OBJECTIVE: To evaluate improvements in otologic symptoms after endoscopic sinus surgery (ESS) in patients with chronic rhinosinusitis (CRS), and identify differences in symptoms, if any, between CRS patients with (CRSwNP) and without (CRSsNP) nasal polyposis. STUDY DESIGN: Prospective multi-center observational cohort study. SETTING: Academic tertiary medical centers. SUBJECTS AND METHODS: Adults with medically recalcitrant CRS who elected ESS were enrolled in a prospective, multi-center, observational cohort study between March, 2011 and October, 2014...
March 2017: World journal of otorhinolaryngology—head and neck surgery
https://www.readbyqxmd.com/read/28986688/unconventional-myosin-id-is-involved-in-remyelination-after-cuprizone-induced-demyelination
#12
Reiji Yamazaki, Hiroko Baba, Yoshihide Yamaguchi
Myelin, which is a multilamellar structure that sheathes the axon, is essential for normal neuronal function. In the central nervous system (CNS), myelin is produced by oligodendrocytes (OLs), which wrap their plasma membrane around axons. The dynamic membrane trafficking system, which relies on motor proteins, is required for myelin formation and maintenance. Previously, we reported that myosin ID (Myo1d) is distributed in rat CNS myelin and is especially enriched in the outer and inner cytoplasm-containing loops...
October 6, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28983650/-eosinophilic-granulomatosis-with-polyangiitis-churg-strauss-syndrome
#13
REVIEW
A Jerrentrup, T Müller, J Mariss, S Dylla
This article presents the case of a patient with dyspnea, a history of poorly controlled asthma, sinonasal polyposis, blood eosinophilia and transient pulmonary infiltrates. The autoantibodies antinuclear antibodies, cytoplasmic anti-neutrophil cytoplasmic antibodies (c-ANCA) and perinuclear anti-neutrophil cytoplasmic antibodies (p-ANCA) were negative. These symptoms are typical for eosinophilic granulomatosis with polyangiitis (EGPA, alternatively known as Churg-Strauss syndrome). The delay between onset and diagnosis in this case was several years...
October 5, 2017: Der Internist
https://www.readbyqxmd.com/read/28982714/interkinetic-nuclear-migration-and-basal-tethering-facilitates-post-mitotic-daughter-separation-in-intestinal-organoids
#14
Thomas D Carroll, Alistair J Langlands, James M Osborne, Ian P Newton, Paul L Appleton, Inke Näthke
Homeostasis of renewing tissues requires balanced proliferation, differentiation and movement. This is particullary important in the intestinal epithelium where lineage tracing suggests that stochastic differentiation choices are intricately coupled to position relative to a niche. To determine how position is achieved we followed proliferating cells in intestinal organoids and discovered that behaviour of mitotic sisters predicted long-term positioning. We found that normally, 70% of sisters remain neighbours while 30% lose contact and separate after cytokinesis...
October 5, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28979711/clinical-predictors-for-sessile-serrated-polyposis-syndrome-a-case-control-study
#15
Yang Wu, Alexander Mullin, Alina Stoita
AIM: To compared individuals with serrated polyposis syndrome (SPS) to those with sessile serrated adenoma (SSA) and adenomas in the setting of endoscopists with high adenoma detection rates at a secondary and tertiary academic centre. METHODS: Retrospectively we collated the clinical, endoscopic and histological features of all patients with SPS at St Vincent's public and private hospital in the last 3 years. Patients were identified by searching through 2 pathology databases...
September 16, 2017: World Journal of Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28978970/continuing-medical-education-questions-october-2017-hereditary-colorectal-polyposis-and-cancer-syndromes-a-primer-on-diagnosis-and-management
#16
REVIEW
Ashish Malhotra, M N Paul
No abstract text is available yet for this article.
October 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28978964/continuing-medical-education-october-2017-hereditary-colorectal-polyposis-and-cancer-syndromes-a-primer-on-diagnosis-and-management
#17
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
October 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28978472/adenomatous-polyposis-coli-defines-treg-differentiation-and-anti-inflammatory-function-through-microtubule-mediated-nfat-localization
#18
Sonia Agüera-González, Oliver T Burton, Elena Vázquez-Chávez, Céline Cuche, Floriane Herit, Jérôme Bouchet, Rémi Lasserre, Iratxe Del Río-Iñiguez, Vincenzo Di Bartolo, Andrés Alcover
Adenomatous polyposis coli (APC) is a polarity regulator and tumor suppressor associated with familial adenomatous polyposis and colorectal cancer development. Although extensively studied in epithelial transformation, the effect of APC on T lymphocyte activation remains poorly defined. We found that APC ensures T cell receptor-triggered activation through Nuclear Factor of Activated T cells (NFAT), since APC is necessary for NFAT's nuclear localization in a microtubule-dependent fashion and for NFAT-driven transcription leading to cytokine gene expression...
October 3, 2017: Cell Reports
https://www.readbyqxmd.com/read/28977861/short-stature-homeobox-2-methylation-as-a-potential-noninvasive-biomarker-in-bronchial-aspirates-for-lung-cancer-diagnosis
#19
Shumin Ni, Meng Ye, Tao Huang
Gene methylation has been frequently observed in lung cancer. However, the use of methylated genes in bronchial aspirates of patients with lung cancer remains to be evaluated. The purpose of this study was to analyze whether the detection of genes with aberrant promoter methylation can be useful noninvasive biomarkers in bronchial aspirates from lung cancer. We found that the methylation status of the cyclin-dependent kinase inhibitor 2A (P16), Ras association domain family 1 isoform (RASSF1A), adenomatous polyposis coli (APC) and short stature homeobox 2 (SHOX2) genes was significantly correlated with lung cancer in bronchial aspirates...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28976806/magnetic-compression-anastomosis-magnamosis-for-functional-undiversion-of-ileostomy-in-pediatric-patients
#20
Luzia Toselli, Marcelo Martinez-Ferro, Guillermo Cervio, Dillon Kwiat, Jill Imamura-Ching, Claire E Graves, Brandon Gaston, Michael Harrison
INTRODUCTION: Magnamosis forms a compression anastomosis using self-aligning magnetic Harrison rings. The device has been approved by the Food and Drug Administration for first-in-human testing and has been applied in adults for intestinal anastomosis during urologic reconstructions. We now report the first cases of magnamosis to functionally undivert the fecal stream from a previously created loop ileostomy in pediatric patients. MATERIALS AND METHODS: Case 1: A 4-year-old male underwent a diverting loop ileostomy for malignant bowel obstruction...
October 4, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
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