keyword
https://read.qxmd.com/read/38537150/prediction-of-occult-hemorrhage-in-the-lower-body-negative-pressure-model-initial-validation-of-machine-learning-approaches
#1
JOURNAL ARTICLE
Navid Rashedi, Yifei Sun, Vikrant Vaze, Parikshit Shah, Ryan Halter, Jonathan T Elliott, Norman A Paradis
INTRODUCTION: Detection of occult hemorrhage (OH) before progression to clinically apparent changes in vital signs remains an important clinical problem in managing trauma patients. The resource-intensiveness associated with continuous clinical patient monitoring and rescue from frank shock makes accurate early detection and prediction with noninvasive measurement technology a desirable innovation. Despite significant efforts directed toward the development of innovative noninvasive diagnostics, the implementation and performance of the newest bedside technologies remain inadequate...
March 27, 2024: Military Medicine
https://read.qxmd.com/read/38537063/impella-as-bridge-to-durable-left-ventricular-assist-device-in-acute-myocardial-infarction-cardiogenic-shock-patients
#2
JOURNAL ARTICLE
Silvia Ajello, Marina Pieri, Sara Dormio, Luca Baldetti, Savino Altizio, Filippo Consolo, Pasquale Nardelli, Alessandro Ortalda, Anna Mara Scandroglio
Implantation of durable left ventricular assist device (LVAD) in cardiogenic shock (CS) patients after acute myocardial infarction (AMI) poses specific challenges (small left ventricular size, acute infarct area, need for antithrombotic therapy, status Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) 1 with impaired organ function and derangements in coagulation and inflammatory parameters) which may affect outcomes. We reviewed data of all AMI-CS patients who were implanted LVAD after Impella support at a referral center with the aim to analyze feasibility, timing, and outcomes of durable LVAD implantation after tMCS with Impella due to AMI-CS...
March 28, 2024: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://read.qxmd.com/read/38536887/endothelial-and-inflammatory-pathophysiology-in-dengue-shock-new-insights-from-a-prospective-cohort-study-in-vietnam
#3
JOURNAL ARTICLE
Angela McBride, Huynh Thi Le Duyen, Nguyen Lam Vuong, Phan Vinh Tho, Luong Thi Hue Tai, Nguyen Thanh Phong, Nguyen Thanh Ngoc, Lam Minh Yen, Phung Tran Huy Nhat, Tran Thuy Vi, Martin J Llewelyn, Louise Thwaites, Nguyen Van Hao, Sophie Yacoub
Dengue shock (DS) is the most severe complication of dengue infection; endothelial hyperpermeability leads to profound plasma leakage, hypovolaemia and extravascular fluid accumulation. At present, the only treatment is supportive with intravenous fluid, but targeted endothelial stabilising therapies and host immune modulators are needed. With the aim of prioritising potential therapeutics, we conducted a prospective observational study of adults (≥16 years) with DS in Vietnam from 2019-2022, comparing the pathophysiology underlying circulatory failure with patients with septic shock (SS), and investigating the association of biomarkers with clinical severity (SOFA score, ICU admission, mortality) and pulmonary vascular leak (daily lung ultrasound for interstitial and pleural fluid)...
March 27, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38536593/altered-grooming-cycles-in-transgenic-drosophila
#4
JOURNAL ARTICLE
John M Ringo, Daniel Segal
Head grooming in Drosophila consists of repeated sweeps of the legs across the head, comprising regular cycles. We used the GAL4-UAS system to study the effects of overexpressing shibirets1 and of Adar knockdown via RNA interference, on the period of head-grooming cycles in Drosophila. Overexpressing shibirets1 interferes with synaptic vesicle recycling and thus with cell communication, while Adar knockdown reduces RNA editing of neuronal transcripts for a large number of genes. All transgenic flies and their controls were tested at 22° to avoid temperature effects; in wild type, cycle frequency varied with temperature with a Q10 of 1...
March 27, 2024: Behavior Genetics
https://read.qxmd.com/read/38536534/serial-daily-lactate-levels-association-with-30-day-outcome-in-cardiogenic-shock-patients-treated-with-va-ecmo-a-post-hoc-analysis-of-the-hypo-ecmo-study
#5
JOURNAL ARTICLE
Bruno Levy, Nicolas Girerd, Guillaume Baudry, Kevin Duarte, Samuel Cuau, Jan Bakker, Antoine Kimmoun
BACKGROUND: Reliable predictors of outcomes in venoarterial extracorporeal membrane oxygenation (VA-ECMO) therapy are limited. While elevated lactate levels over time have been linked to outcomes in cardiogenic shock (CS), their significance in VA-ECMO-treated patients remains inconclusive. METHODS: We conducted a post hoc analysis of data from the HYPO-ECMO trial, which compared normothermia to moderate hypothermia in CS patients supported by VA-ECMO. We examined daily lactate levels collected over a week to assess their correlation with 30-day mortality...
March 27, 2024: Annals of Intensive Care
https://read.qxmd.com/read/38536439/mapping-stress-responsive-signaling-pathways-induced-by-mitochondrial-proteostasis-perturbations
#6
JOURNAL ARTICLE
Nicole Madrazo, Zinia Khattar, Evan T Powers, Jessica D Rosarda, R Luke Wiseman
Imbalances in mitochondrial proteostasis are associated with pathologic mitochondrial dysfunction implicated in etiologically-diverse diseases. This has led to considerable interest in defining the mechanisms responsible for regulating mitochondria in response to mitochondrial stress. Numerous stress-responsive signaling pathways have been suggested to regulate mitochondria in response to proteotoxic stress. These include the integrated stress response (ISR), the heat shock response (HSR), and the oxidative stress response (OSR)...
March 27, 2024: Molecular Biology of the Cell
https://read.qxmd.com/read/38535452/synthesis-and-hypoglycemic-effect-of-insulin-from-the-venom-of-sea-anemone-exaiptasia-diaphana
#7
JOURNAL ARTICLE
Qiqi Guo, Tianle Tang, Jingyue Lu, Meiling Huang, Junqing Zhang, Linlin Ma, Bingmiao Gao
Sea anemone venom, abundant in protein and peptide toxins, serves primarily for predatory defense and competition. This study delves into the insulin-like peptides (ILPs) present in sea anemones, particularly focusing on their role in potentially inducing hypoglycemic shock in prey. We identified five distinct ILPs in Exaiptasia diaphana , exhibiting varied sequences. Among these, ILP-Ap04 was successfully synthesized using solid phase peptide synthesis (SPPS) to evaluate its hypoglycemic activity. When tested in zebrafish, ILP-Ap04 significantly reduced blood glucose levels in a model of diabetes induced by streptozotocin (STZ) and glucose, concurrently affecting the normal locomotor behavior of zebrafish larvae...
February 27, 2024: Marine Drugs
https://read.qxmd.com/read/38535230/hsp90-mediated-multi-drug-resistance-in-dna-polymerase-defective-strains-of-candida-albicans
#8
JOURNAL ARTICLE
Bhabasha Gyanadeep Utkalaja, Satya Ranjan Sahu, Sushree Subhashree Parida, Narottam Acharya
The incidence of infections caused by Candida species, specifically by drug-resistant isolates, is a major health concern as they can disseminate to and colonize most vital organs, enhancing morbidity and mortality. Several molecular mechanisms have been reported to be involved in drug resistance. These are mostly drug- and isolate-specific. Here, we characterized three different genetically modified strains of C. albicans that were multi-drug-resistant (MDR) and deciphered a uniform mechanism responsible for resistance...
March 19, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38535187/comparative-transcriptome-profiles-of-the-response-of-mycelia-of-the-genus-morchella-to-temperature-stress-an-examination-of-potential-resistance-mechanisms
#9
JOURNAL ARTICLE
Yihong Yue, Haibo Hao, Qian Wang, Tingting Xiao, Yuchen Zhang, Hui Chen, Jinjing Zhang
Temperature and moisture belong to the most important environmental factors affecting the growth and development of fungi. However, the effect of temperature on the mycelia of the edible Morchella mushrooms has not been determined. Here, a comprehensive analysis was performed to determine the influence of culture temperature on 13 strains of mycelia of three Morchella species ( Morchella sextelata , Morchella septimelata , and Morchella importuna ) at 5 °C, 10 °C, 15 °C, 20 °C, 25 °C, and 30 °C...
February 27, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38535173/the-dynamic-interaction-between-oil-palm-and-phytophthora-palmivora-in-bud-rot-disease-insights-from-transcriptomic-analysis-and-network-modelling
#10
JOURNAL ARTICLE
Mariandrea García-Gaona, David Botero-Rozo, Leonardo Araque, Hernán Mauricio Romero
Bud Rot, caused by Phytophthora palmivora , is considered one of the main diseases affecting African oil palm ( Elaeis guineensis ). In this study, we investigated the in vitro molecular dynamics of the pathogen-host interaction by analyzing gene expression profiles from oil palm genotypes that were either susceptible or resistant to the disease. We observed distinct interactions of P. palmivora with resistant and susceptible oil palms through co-expression network analysis. When interacting with susceptible genotypes, P...
February 20, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38535120/triple-silencing-of-hsp27-cflip-and-clu-genes-promotes-the-sensitivity-of-doxazosin-induced-apoptosis-in-pc-3-prostate-cancer-cells
#11
JOURNAL ARTICLE
Jeong Man Cho, Sojung Sun, Eunji Im, Hyunwon Yang, Tag Keun Yoo
Background: This study investigated how the expression of heat shock protein 27 (HSP27), cellular FLICE-like inhibitory protein (cFLIP), and clusterin (CLU) affects the progression of cancer cells and their susceptibility to doxazosin-induced apoptosis. By silencing each of these genes individually, their effect on prostate cancer cell viability after doxazosin treatment was investigated. Methods: PC-3 prostate cancer cells were cultured and then subjected to gene silencing using siRNA targeting HSP27, cFLIP, and CLU, either individually, in pairs, or all together...
February 21, 2024: Medicines (Basel, Switzerland)
https://read.qxmd.com/read/38534976/wild-type-ampc-beta-lactamase-producing-enterobacterales-are-a-risk-factor-for-empirical-treatment-failure-in-patients-with-bloodstream-infection
#12
JOURNAL ARTICLE
Matteo Vassallo, Roxane Fabre, Laurene Lotte, Sabrina Manni, Christian Pradier
Introduction: Beta-lactamases are frequently prescribed for Gram-negative bloodstream infections (BSIs). However, chromosomally encoded AmpC-producing Enterobacterales (AE) could overproduce beta-lactamases when exposed to third-generation cephalosporins (3GCs), with a risk of clinical failure. There are few available in vivo data on the subject. Our goal was to assess the potential role of AE as a predictive factor for clinical failure in patients with BSIs. Materials and Methods: We retrospectively analyzed patients admitted to Cannes hospital between 2021 and 2022 for BSIs due to Enterobacterales ...
March 2, 2024: Diseases (Basel)
https://read.qxmd.com/read/38534717/risk-factors-and-outcomes-of-community-acquired-carbapenem-resistant-klebsiella-pneumoniae-infection-in-elderly-patients
#13
JOURNAL ARTICLE
Yen-Chou Chen, I-Ting Tsai, Chung-Hsu Lai, Kuo-Hsuan Lin, Yin-Chou Hsu
The increasing prevalence of carbapenem-resistant Klebsiella pneumoniae (CRKP) infections is a global concern. Elderly patients have a diminished immune response and functional reserve, and are thus more vulnerable to bacterial infection. This study aimed to investigate the risk factors and outcomes in elderly patients with community-acquired CRKP infections. We performed a retrospective cohort study in a tertiary medical center between 1 January 2021, and 31 December 2021. All elderly patients who visited the emergency department during this period with culture-positive K...
March 20, 2024: Antibiotics
https://read.qxmd.com/read/38534712/multiple-drug-resistant-streptococcus-strains-an-actual-problem-in-pig-farms-in-western-romania
#14
JOURNAL ARTICLE
Luminita Costinar, Corina Badea, Adela Marcu, Corina Pascu, Viorel Herman
Streptococci are a type of bacteria that can cause severe illnesses in humans and animals. Some typical species like S. suis , or atypical species like S. porcinus and, S. dysgalactiae subsp. dysgalactiae , can cause infections like septicemia, meningitis, endocarditis, arthritis, and septic shock. S. suis is considered a newly emerging zoonotic pathogen. Although human streptococcal infection outbreaks are rare, it is appropriate to review the main streptococcal species isolated in pig farms in western Romania, due to the high degree of antibiotic resistance among most isolates commonly used in human treatment...
March 19, 2024: Antibiotics
https://read.qxmd.com/read/38534664/efficacy-of-continuous-vs-intermittent-administration-of-cefepime-in-adult-icu-patients-with-gram-negative-bacilli-bacteremia-a-randomized-double-blind-clinical-study
#15
JOURNAL ARTICLE
Carlos Arturo Álvarez-Moreno, Laura Cristina Nocua-Báez, Guillermo Ortiz, Juan Carlos Torres, Gabriel Montenegro, Williams Cervera, Luis Fernando Zuluaga, Alonso Gómez
INTRODUCTION: The objective of this study was to compare the continuous infusion of cefepime with the intermittent infusion in patients with sepsis caused by Gram-negative bacilli (GNB). METHODS: Randomized 1:1 multicenter double-blinded placebo-controlled study with allocation concealment; multicenter study in the intensive care units of Colombia. Patients with sepsis, severe sepsis or septic shock, and GNB-suspected bacteremia. Cefepime was administered for 7 to 14 days over 30 m intermittently every 8 h over 24 h plus continuous saline solution (0...
February 29, 2024: Antibiotics
https://read.qxmd.com/read/38534389/harnessing-extracellular-micrornas-for-diagnostics-and-therapeutics-in-acute-systemic-inflammation
#16
REVIEW
Russell Hollis, Monowar Aziz, Asha Jacob, Ping Wang
Micro-ribonucleic acids (miRNAs) are small sequences of genetic materials that are primarily transcribed from the intronic regions of deoxyribonucleic acid (DNAs), and they are pivotal in regulating messenger RNA (mRNA) expression. miRNAs were first discovered to regulate mRNAs of the same cell in which they were transcribed. Recent studies have unveiled their ability to traverse cells, either encapsulated in vesicles or freely bound to proteins, influencing distant recipient cells. Activities of extracellular miRNAs have been observed during acute inflammation in clinically relevant pathologies, such as sepsis, shock, trauma, and ischemia/reperfusion (I/R) injuries...
March 19, 2024: Cells
https://read.qxmd.com/read/38534386/in-vitro-effects-of-charged-and-zwitterionic-liposomes-on-human-spermatozoa-and-supplementation-with-liposomes-and-chlorogenic-acid-during-sperm-freezing
#17
JOURNAL ARTICLE
Elena Moretti, Claudia Bonechi, Cinzia Signorini, Roberta Corsaro, Lucia Micheli, Laura Liguori, Gabriele Centini, Giulia Collodel
Semen handling and cryopreservation induce oxidative stress that should be minimized. In this study, human semen was supplemented during cryopreservation with formulations of handmade liposomes and chlorogenic acid (CGA), an antioxidant compound. Zwitterionic (ZL), anionic (AL), and cationic (CL) liposomes were synthesized and characterized. Three aliquots of swim-up-selected sperm were incubated with ZL, AL, and CL (1:10,000), respectively. The percentages of sperm with progressive motility, high mitochondrial membrane potential (MMP; JC-1), double-stranded DNA (dsDNA acridine orange), and acrosome integrity ( Pisum sativum agglutinin) were assessed...
March 19, 2024: Cells
https://read.qxmd.com/read/38534372/hsp47-increases-the-expression-of-type-i-collagen-in-fibroblasts-through-ire1%C3%AE-activation-xbp1-splicing-and-nuclear-translocation-of-%C3%AE-catenin
#18
JOURNAL ARTICLE
So Young Ham, Min Ju Pyo, Moonkyung Kang, Yeon-Soo Kim, Dong Hun Lee, Jin Ho Chung, Seung-Taek Lee
Heat shock protein 47 (HSP47), also known as SERPINH1 , functions as a collagen-specific molecular chaperone protein essential for the formation and stabilization of the collagen triple helix. Here, we delved into the regulatory pathways governed by HSP47, shedding light on collagen homeostasis. Our investigation revealed a significant reduction in HSP47 mRNA levels in the skin tissue of older mice as compared to their younger counterparts. The augmented expression of HSP47 employing lentivirus infection in fibroblasts resulted in an increased secretion of type I collagen...
March 17, 2024: Cells
https://read.qxmd.com/read/38534205/meningeal-damage-and-interface-astroglial-scarring-in-the-rat-brain-exposed-to-a-laser-induced-shock-wave-s
#19
JOURNAL ARTICLE
Satoko Kawauchi, Akemi Kono, Yuriko Muramatsu, Grant Hennes, Shuta Seki, Susumu Tominaga, Yasue Haruyama, Yukari Komuta, Izumi Nishidate, Susumu Matsukuma, Yushan Wang, Shunichi Sato
In the past decade, signature clinical neuropathology of blast-induced traumatic brain injury has been under intense debate, but interface astroglial scarring (IAS) seems to be convincing. In this study, we examined whether IAS could be replicated in the rat brain exposed to a laser-induced shock wave(s) (LISW[s]), a tool that can produce a pure shock wave (primary mechanism) without dynamic pressure (tertiary mechanism). Under certain conditions, we observed astroglial scarring in the subpial glial plate (SGP), grey-white matter junctions (GM-WM), ventricular wall (VW) and regions surrounding cortical blood vessels, accurately reproducing clinical IAS...
March 27, 2024: Journal of Neurotrauma
https://read.qxmd.com/read/38534184/orbital-fracture-characteristics-and-outcomes-in-baltimore
#20
JOURNAL ARTICLE
Seray Er, Bashar Hassan, Joshua Yoon, Eric Resnick, Cynthia Yusuf, Tomer Lagziel, Fan Liang, Thomas Ptak, Richard Redett, Robin Yang, Michael Grant
Fracture characteristics and postoperative outcomes of patients presenting with orbital fractures in Baltimore remain poorly investigated. The purpose of our study was to determine the fracture patterns, etiologies, and postoperative outcomes of patients treated for orbital fractures at 2 level I trauma centers in Baltimore. A retrospective cohort study was conducted on patients who underwent orbital fracture repair at the R Adams Cowley Shock Trauma Center and the Johns Hopkins Hospital from January 2015 to December 2019...
March 27, 2024: Journal of Craniofacial Surgery
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