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Shigeru Hattori, Kenichiro Noguchi, Yusuke Gunji, Motoki Nagatsuka, Tsuyoshi Yamabe, Hidemitsu Ogino, Ikuo Katayama
Conversion to open repair after thoracic endovascular aortic repair (TEVAR) for acute type B aortic dissection is rare, but inevitable. We present a case of an 86-year-old man with ruptured type B aortic dissection after TEVAR. He received a successful stent-graft implantation of the descending aorta without any type of endoleak. After the patient was transferred to the intensive care unit, he went into a shock state. Contrast-enhanced CT revealed a re-rupture of acute retrograde type B aortic dissection. The false lumen was patent and perforated to the left thorax...
September 22, 2018: General Thoracic and Cardiovascular Surgery
Shiva K Annamalai, Michele L Esposito, Lena Jorde, Theodore Schreiber, Shelley Hall, William W O'Neill, Navin K Kapur
BACKGROUND: Myocarditis complicated by cardiogenic shock remains a complex problem. The use of acute mechanical circulatory support devices for cardiogenic shock is growing. We explored the utility of Impella trans-valvular micro-axial flow catheters in the setting of myocarditis with cardiogenic shock. METHODS AND RESULTS: We retrospectively analyzed data from 21 sites within the cVAD registry, an ongoing multicenter voluntary registry at sites in North America and Europe that have used Impella in patients with myocarditis...
September 20, 2018: Journal of Cardiac Failure
Francesca Biagioni, Anderson Gaglione, Filippo S Giorgi, Domenico Bucci, Slavianka Mojanova, Antonio De Fusco, Michele Madonna, Francesco Fornai
Status epilepticus of limbic onset might cause degenerative phenomena in different brain structures, and may be associated with chronic cognitive and EEG effects. In the present study SE was evoked focally by microinfusing picomolar doses of cyclothiazide+bicuculline into the anterior extent of the piriform cortex (APC) in rats, the so-called area tempestas, an approach which allows to evaluate selectively the effects of seizure spreading through the natural anatomical circuitries up to secondary generalization...
September 20, 2018: Neurobiology of Disease
Wei-Syun Hu, Cheng-Li Lin
OBJECTIVE: This investigation aimed at assessing the issue of incident atrial fibrillation (AF) associated with acute critical illness. METHODS: The study came from Taiwan and used that nation's Longitudinal Health Insurance Database 2000. Using propensity score matching, multivariable adjustment and competing risk methods, the correlations between the new-onset AF and critical illness (septicemia/septic shock, acute myocardial infarction【AMI】, hemorrhagic stroke and ischemic stroke) were investigated...
September 19, 2018: European Journal of Internal Medicine
Kanta Kido, Yuki Shindo, Shinichi Toda, Eiji Masaki
BACKGROUND: Endogenous β-endorphin is delivered exclusively from the pituitary gland in various stressful conditions and plays an essential role in the nervous system. Recently, a few studies demonstrated peripheral endogenous opioid secretion from immune cells at inflammatory sites. Here, we investigated the expression of β-endorphin, the most powerful endogenous opioid peptide, in peripheral tissues in response to systemic administration of lipopolysaccharide in mice. METHODS: Male C57BL/6N mice received intravenously administered lipopolysaccharide to induce an endotoxic shock-like condition...
September 19, 2018: Annales D'endocrinologie
X Bidault, N Pineau
We use molecular dynamics simulations with the ReaxFF-lg potential to model the high pressure pyrolysis of carbon suboxide (C3 O2 ) in mixture with argon as a pressure bath. We show that the reactive simulations catch the experimental behavior of the low-pressure detonation of C3 O2 (around 10 bars in shock tube experiments) and allow extrapolations to the high-pressure range of solid-state explosive detonation (up to 60 GPa). While at low pressure carbonaceous nanostructures are formed through the aggregation of species such as carbon dimers C2 , it appears that the high pressure deeply modifies the process, with the aggregation of growing Cx Oy heterostructures, in which the oxygen amount is driven by the pressure and the temperature...
September 21, 2018: Journal of Chemical Physics
Anita Somborac-Bačura, Lada Rumora, Ruđer Novak, Dubravka Rašić, Jerka Dumić, Ivana Čepelak, Tihana Žanić-Grubišić
NEW FINDINGS: What is the central question of this study? Cigarette smoking is associated with increased oxidative stress and apoptosis in lungs. Our aim was to examine the effect of cigarette smoke on cell death, oxidative damage, expression of heat shock proteins (HSPs) and activation of mitogen-activated protein kinases (MAPKs) in A549 alveolar epithelial cells. What is the main finding and its importance? Cigarette smoke induces cytotoxicity and oxidative damage to A549 cells, increases expression of different HSPs and activates MAPK signaling pathways...
September 22, 2018: Experimental Physiology
Enzo Hollville, Antoine Nordez, Gaël Guilhem, Jennyfer Lecompte, Giuseppe Rabita
Animal tendons have been shown to act as shock absorbers to protect muscle fascicles from exercise-induced damage during landing tasks. Meanwhile, the contribution of tendinous tissues to damping activities such as landing has been less explored in humans. The aim of this study was to analyze in vivo fascicle-tendon interactions during drop landing to better understand their role in energy dissipation. Ultrafast ultrasound images of the gastrocnemius medialis (GM) and vastus lateralis (VL), lower limb electromyographic activity, 2-D kinematics and ground reaction forces were collected from twelve participants during single and double-leg drop landings from various heights...
September 22, 2018: Scandinavian Journal of Medicine & Science in Sports
Yousef H Darrat, Francis Benn, Mohsin Salih, Jignesh Shah, Kevin Parrott, Gustavo X Morales, John Gurley, Samy-Claude Elayi
BACKGROUND: Subcutaneous implantable cardioverter defibrillators (S-ICDs) have gained increasing popularity because of certain advantages over transvenous ICDs. However, while conventional ICDs require a single surgical incision to implant, S-ICDS need two or three incisions, making them less appealing. OBJECTIVE: This study sought out to investigate the feasibility of using a single incision technique to implant S-ICDs. METHODS: Patients qualifying for S-ICDs were considered for a single incision...
September 22, 2018: Pacing and Clinical Electrophysiology: PACE
Zhe Sha, Jinghui Zhao, Alfred L Goldberg
In certain physiological or pathological states (e.g., starvation, heat shock, or muscle atrophy) and upon drug treatments, the overall rate of protein degradation in cells may increase or decrease. These adaptations and pathological responses can occur through alterations in substrate flux through the ubiquitin-proteasome pathway (UPP), the autophagy-lysosomal system, or both. Therefore, it is important to precisely measure the activities of these degradation pathways in degrading cell proteins under different physiological states or upon treatment with drugs...
2018: Methods in Molecular Biology
Sheng-Der Hsu, Cheng-Jueng Chen, I-Duo Wang, Kuen-Tze Lin, Chia-Chi Wang, Wu-Chien Chien, Chi-Hsiang Chung, Wei-Kuo Chang
BACKGROUND: Pelvic fracture with hypovolemic shock is a known crucial injury in trauma patients. Pelvic fracture with vessel injury often leads to hemodynamic complications; in a trauma scenario, evidence of other systems being affected is often absent. Bleeding cessation and resuscitation are important for these types of trauma patients. For this purpose, pelvic angiographic embolization is frequently used. Multiple studies have reported that angiographic embolization may cause erectile dysfunction (ED) in hemodynamically stable patients with pelvic fracture...
September 21, 2018: World Journal of Surgery
Ximin Zeng, Zuowei Wu, Qijing Zhang, Jun Lin
Conjugation is an important mechanism for horizontal gene transfer in Campylobacter jejuni , the leading cause of human bacterial gastroenteritis in developed countries. However, to date, the factors that significantly influence conjugation efficiency in Campylobacter are still largely unknown. Given that multiple recombinant loci could independently occur within one recipient cell during natural transformation, the genetic materials from high frequency conjugation ( HFC ) C. jejuni strain may be co-transformed with a selection marker into a low frequency conjugation ( LFC ) recipient strain, creating new HFC transformants suitable for identification of conjugation factor using comparative genomics approach...
September 21, 2018: Applied and Environmental Microbiology
Mark Anderson, D Lynn Morris, Daniel Tang, George Batsides, Ajay Kirtane, Ivan Hanson, Perwais Meraj, Navin Kapur, William O'Neill
BACKGROUND: Right ventricular failure (RVF) after myocardial infarction, cardiotomy, or left ventricular assist device (LVAD) implantation increases morbidity and mortality. RVF also contributes to prolonged length of hospital stay and higher costs of care. The aim of this study was to evaluate the efficacy and safety of the Impella RP (Abiomed, Danvers, MA) in patients with severe RVF in these clinical settings. METHODS: This is a prospective cohort study of patients with severe RVF treated with a percutaneous right ventricular assist device (RVAD)...
August 8, 2018: Journal of Heart and Lung Transplantation
Stefanie G Ames, Christopher M Horvat, Arno Zaritsky, Joseph A Carcillo
No abstract text is available yet for this article.
September 22, 2018: Critical Care: the Official Journal of the Critical Care Forum
Fernanda O Lemos, Dalton Dittz, Verlane G Santos, Simone F Pires, Hélida M de Andrade, Carlos E Salas, Miriam T P Lopes
Previous studies showed that P1G10, a proteolytic fraction from Vasconcellea cundinamarcensis latex, reduced the tumor mass in animals bearing melanoma, increased in vitro DNA fragmentation and decreased cell adhesion. Here, we present some molecular and cellular events related to the antimetastatic effect induced by the CMS-2 fraction derived from P1G10 in metastatic melanoma B16-F10 and melanocyte Melan-a. Using difference gel electrophoresis and mass spectrometry, we identified four proteins overexpressed in tumor cells, all of them related to proliferation, survival, migration and cell invasion, that had their expression normalized upon treatment with CMS-2: nucleophosmin 1, heat shock protein 65, calcyclin binding protein and eukaryotic translation initiation factor 4H...
September 20, 2018: International Journal of Molecular Sciences
Cho-Hao Lee, Chung-Kan Peng, Shan-Yueh Chang, Chih-Hao Shen, Kun-Lun Huang
Severe decompression illness (DCI) is an uncommon medical issue affecting divers and results mainly from rapid surfacing using inadequate decompression protocols. Massive gas embolism with central nervous system involvement often leads to a poor prognosis, with permanent residual neurologic defects. Moreover, DCI complicated with multiple organ dysfunction syndrome (MODS) is tremendously rare and difficult to cure, although hyperbaric oxygen (HBO2) therapy following the U.S. Navy Treatment Tables is a consensus...
July 2018: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
JoAn R Laes, Stephen Hendriksen, Jon B Cole
Introduction: Hyperbaric oxygen (HBO2 ) therapy is infrequently reported as a treatment for poison-induced retinal damage. We describe a case in which HBO2 therapy was used to treat suspected retinal toxicity induced by quinine. Case report: We present a case in which HBO2 was used to treat visual disturbances thought to be caused by quinine-induced retinal damage. The patient intentionally ingested undisclosed amounts of citalopram and quinine. Following a complicated hospital course, including profound shock requiring treatment with four vasopressors and a peripheral left-ventricular assist device, the patient, once extubated, reported visual abnormalities consistent with those described from quinine-induced retinal toxicity...
July 2018: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
Rie Kubota, Katsuki Matsubara, Kenichi Tamukai, Kazunori Ike, Toshihiro Tokiwa
Long-tailed chinchillas Chinchilla lanigera are a popular rodent species kept both in households, where they are hand-raised as pets, and in zoological facilities. From January 2016 to February 2017, 13 juvenile chinchillas from five facilities in Japan were diagnosed with cryptosporidiosis at the animal hospital. Eight of the cases were fatal. All of the animals were imported from the Czech Republic by the same vendor. Histopathological and multilocus sequence analyses using 18S ribosomal RNA, actin, 70-kDa heat shock protein, and 60-kDa glycoprotein genes confirmed Cryptosporidium ubiquitum of subtype XIId as the etiological agent...
September 18, 2018: Parasitology International
Xianli An, Fenfen Zhang, Yuan Liu, Ping Yang, Duonan Yu
Exposure of some individuals to recurring traumatic events from the same perpetrator or situation, such as during child abuse or domestic violence, is quite prevalent. Studies have shown that the number of traumatic events experienced is positively related to the severity of post-traumatic stress disorder (PTSD) and other mental disorders. Using a contextual fear conditioning (Cond1) and reconditioning (Cond2) paradigm, which were separated by either 1 or 35 days, we examined fear responses to immediate extinction and retrieval-extinction procedures after repeated fear conditioning stress...
September 18, 2018: Behavioural Brain Research
Dongxia Zhang, Jingtao Ma
BACKGROUND Patients treated with 5-FU can develop rare but potentially severe cardiac effects, including cardiomyopathy, angina pectoris, ventricular tachycardia, heart failure, acute myocardial infarction, and cardiogenic shock. The specific pathologies and mechanisms are not fully understood. Research found that mitochondrial dynamics are widely detected in many angiocardiopathies. Therefore, in the present study we studied the mitochondrial damage and explored the role of mitochondrial fusion/fission proteins on myocardium of rats treated with 5-fluorouracil (5-FU)...
September 21, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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