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Collagenous colitis

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https://www.readbyqxmd.com/read/29742325/microscopic-colitis-a-population-based-case-series-over-a-nine-year-period-in-northern-ireland
#1
Michelle Moore, Helen G Coleman, Patrick B Allen, Maurice B Loughrey
AIM: We report clinicopathological experience of microscopic colitis in a population-based case series in Northern Ireland, over a nine year period. METHOD: The pathology laboratory information system within a large teaching centre serving two healthcare trusts was interrogated for cases coded between 2008 and 2016 as collagenous colitis (CC) or lymphocytic colitis (LC). Demographic, clinical and follow up information was collected from healthcare records. RESULTS: A total of 326 new diagnoses of MC were identified, an average annual incidence of 6...
May 9, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29668937/knockdown-of-smad7-with-a-specific-antisense-oligonucleotide-attenuates-colitis-and-colitis-driven-colonic-fibrosis-in-mice
#2
Roberta Izzo, Gerolamo Bevivino, Veronica De Simone, Silvia Sedda, Ivan Monteleone, Irene Marafini, Martina Di Giovangiulio, Angelamaria Rizzo, Eleonora Franzè, Alfredo Colantoni, Angela Ortenzi, Giovanni Monteleone
Background: In Crohn's disease (CD), the pathogenic immune response is associated with high Smad7, an inhibitor of TGF-β1 signaling. Smad7 knockdown with Mongersen, a specific antisense oligonucleotide-containing compound, restores TGF-β1 activity leading to inhibition of inflammatory signals and associates with clinical benefit in CD patients. As TGF-β1 is pro-fibrogenic, it remains unclear whether Mongersen-induced Smad7 inhibition increases the risk of intestinal fibrosis. We assessed the impact of Smad7 inhibition on the course of colitis-driven intestinal fibrosis in mice...
April 13, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29610757/the-subtypes-of-microscopic-colitis-from-a-pathologist-s-perspective-past-present-and-future
#3
Peter Johan Heiberg Engel, Anne-Marie Kanstrup Fiehn, Lars Kristian Munck, Martin Kristensson
Microscopic colitis (MC) is a chronic inflammatory bowel disease, encompassing a triad of chronic diarrhea, normal endoscopy and characteristic histological findings. MC embraces two histological subtypes described as lymphocytic colitis (LC) and collagenous colitis (CC). The diagnostic criteria of MC were established several years ago and the histological description of LC and CC was based almost exclusively on heamatoxylin-eosin (HE) stained sections. Since the establishment of the diagnostic criteria, important changes have occurred in the concept and diagnostic methods of MC: the emergence of the entity "microscopic colitis incomplete" (MCi), comprising collagenous colitis incomplete (CCi) and lymphocytic colitis incomplete (LCi) and pathologists' increasing use of special stains in everyday diagnostics...
February 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29610507/vedolizumab-as-a-novel-treatment-for-refractory-collagenous-colitis-a-case-report
#4
Kelly C Cushing, Mari Mino-Kenudson, John Garber, Paul Lochhead, Hamed Khalili
No abstract text is available yet for this article.
April 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29603368/oral-budesonide-in-gastrointestinal-and-liver-disease-a-practical-guide-for-the-clinician
#5
REVIEW
Stephan Miehlke, Manuel Barreiro-de Acosta, Gerd Bouma, Daniel Carpio, Fernando Magro, Tom Moreels, Chris Probert
Oral budesonide is a second- generation steroid which allows local, selective treatment of the gastrointestinal tract and the liver, minimizing systemic exposure. The results of randomized trials comparing budesonide versus placebo or active comparators have led to expert recommendations that budesonide be used to treat mild or moderate active ileocecal Crohn's disease, microscopic colitis (including both collagenous and lymphocytic colitis), ulcerative colitis and non-cirrhotic autoimmune hepatitis. The mechanism of budesonide action obviates the need for dose tapering due to safety reasons after induction therapy...
March 30, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29601434/pediatric-collagenous-gastritis-and-colitis-a-case-series-and-review-of-the-literature
#6
Judy Matta, George Alex, Donald J S Cameron, Chung W Chow, Winita Hardikar, Ralf G Heine
INTRODUCTION: Collagenous gastritis is a rare disease characterized by the subepithelial deposition of collagen bands. Two phenotypes of the disease have been described: a pediatric-onset and an adult-onset type. The adult-onset form is associated with collagenous colitis and autoimmune disorders. No effective treatment has been identified to date. OBJECTIVE: We aim to describe the clinical features and outcomes of patients in our cohort and provide a summary of published pediatric cases with collagenous gastritis and colitis reported to date to gather information that will contribute to improved knowledge of this rare condition...
March 29, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29596895/microscopic-ileitis-in-diverted-and-non-diverted-enteric-segments-an-under-recognized-condition-with-a-multifactorial-etiology
#7
Chunlai Zuo, Zhiyan Fu, Edward C Lee, Llewellyn Foulke, Gloria Q Young, David Cubero Rego, Hwajeong Lee
Microscopic ileitis has been infrequently reported in the literature with the few reported cases usually associated with concurrent microscopic colitis. Having encountered a case of collagenous ileitis involving the diverted distal limb of a loop ileostomy and sparing the proximal limb, we examined additional cases of loop ileostomy, end ileostomy, colostomy, and the accompanying diverted colorectal segment for features of microscopic ileitis and colitis. A total of 101 cases of diverted and non-diverted enteric segments were examined from 37 loop ileostomies, 16 end ileostomies and 12 colostomies status post Hartmann's procedure...
March 26, 2018: Human Pathology
https://www.readbyqxmd.com/read/29552620/activation-of-myofibroblast-trpa1-by-steroids-and-pirfenidone-ameliorates-fibrosis-in-experimental-crohn-s-disease
#8
Lin Hai Kurahara, Keizo Hiraishi, Yaopeng Hu, Kaori Koga, Miki Onitsuka, Mayumi Doi, Kunihiko Aoyagi, Hidetoshi Takedatsu, Daibo Kojima, Yoshitaka Fujihara, Yuwen Jian, Ryuji Inoue
Background & Aims: The transient receptor potential ankyrin 1 (TRPA1) channel is highly expressed in the intestinal lamina propria, but its contribution to gut physiology/pathophysiology is unclear. Here, we evaluated the function of myofibroblast TRPA1 channels in intestinal remodeling. Methods: An intestinal myofibroblast cell line (InMyoFibs) was stimulated by transforming growth factor-β1 to induce in vitro fibrosis. Trpa1 knockout mice were generated using the Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated 9 (Cas9) system...
March 2018: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29546806/microscopic-colitis-in-patients-with-ulcerative-colitis-or-crohn-s-disease-a-retrospective-observational-study-and-review-of-the-literature
#9
Anna Wickbom, Johan Bohr, Nils Nyhlin, Anders Eriksson, Annika Lapidus, Andreas Münch, Kjell-Arne Ung, Lina Vigren, Åke Öst, Curt Tysk
OBJECTIVES: Onset of microscopic colitis (MC) in patients with ulcerative colitis (UC) or Crohn's disease (CD), or vice versa, has been reported occasionally but the subject is not well described. We therefore report a retrospective observational study of such patients and review the literature. METHODS: Forty-six Swedish gastroenterology clinics were contacted about patients with diagnoses of both inflammatory bowel disease (IBD) and MC. Publications were searched on PubMed...
April 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29535059/associations-of-microscopic-colitis-with-other-lymphocytic-disorders-of-the-gastrointestinal-tract
#10
Amnon Sonnenberg, Kevin O Turner, Robert M Genta
BACKGROUND & AIMS: Lymphocytic disorders of the upper and lower gastrointestinal tract seem to cluster in patients. We aimed to assess the frequency of comorbid occurrence of lymphocytic disorders in patients with microscopic colitis (MC). METHODS: We collected data from the Miraca Life Sciences Database, a large national electronic repository of histopathologic records of patients throughout the United States. In a population of 228,506 patients who underwent bidirectional endoscopy from January 2008 through July 2016, we studied the comorbid occurrence of celiac disease, duodenal intraepithelial lymphocytosis, lymphocytic gastritis, and lymphocytic esophagitis among 3456 patients with MC...
March 11, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29525889/nobiletin-acts-anti-inflammatory-on-murine-il-10-colitis-and-human-intestinal-fibroblasts
#11
Yvonne Hagenlocher, Sonja Gommeringer, Anna Held, Katharina Feilhauer, Jörg Köninger, Stephan C Bischoff, Axel Lorentz
PURPOSE: Inflammatory bowel disease (IBD) shows increasing prevalence over the last years. We propose that anti-inflammatory plant substances could be used as additional or alternative agents with good compliance in prevention and/or therapy of IBD and its complication intestinal fibrosis. We could recently show that the citrus flavonoid nobiletin acts anti-inflammatory on activation of intestinal mast cells. Here, we analysed the effects of nobiletin on inflammation and fibrosis in IL-10-/- colitis...
March 10, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29466999/a-probiotic-complex-rosavin-zinc-and-prebiotics-ameliorate-intestinal-inflammation-in-an-acute-colitis-mouse-model
#12
Jin-Sil Park, JeongWon Choi, Ji Ye Kwon, Kyung-Ah Jung, Chul Woo Yang, Sung-Hwan Park, Mi-La Cho
BACKGROUND: An altered gut microbiota balance is involved in the pathogenesis of inflammatory bowel disease (IBD), and several probiotic strains are used as dietary supplements to improve intestinal health. We evaluated the therapeutic effect of 12 probiotics in combination with prebiotics, rosavin, and zinc in the dextran sodium sulfate (DSS)-induced colitis mouse model. METHODS: The probiotic complex or the combination drug was administered orally to mice with DSS-induced colitis, and the body weight, disease activity index, colon length, and histopathological parameters were evaluated...
February 21, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29457048/farnesoid-x-receptor-expression-in-microscopic-colitis-a-potential-role-in-disease-etiopathogenesis
#13
Joana Torres, Carolina Palmela, Pedro Gomes de Sena, Maria Pia Costa Santos, Catarina Gouveia, Maria Helena Oliveira, Ana Raquel Henriques, Cecília Rodrigues, Marília Cravo, Paula Borralho
Introduction: Microscopic colitis (MC) is a chronic inflammatory bowel disease with unclear etiology. Bile acid (BA) malabsorption has been described in MC patients. Farnesoid X receptor (FXR) is the main BA receptor; FXR-mediated mechanisms prevent the noxious effects of BA accumulation, preserving the integrity of the intestinal epithelial barrier and preventing intestinal inflammation. Aim: Our aim was to describe the expression of FXR in patients with MC. Methods: Archival formalin-fixed paraffin-embedded samples from the terminal ileum, right and left colon were obtained from patients with MC and matched controls...
January 2018: GE Portuguese Journal of Gastroenterology
https://www.readbyqxmd.com/read/29452215/lymphocytic-colitis-pathologic-predictors-of-response-to-therapy
#14
Namrata Setia, Lindsay Alpert, Kimberley Wj van der Sloot, Dora Colussi, Kathleen O Stewart, Joseph Misdraji, Hamed Khalili, Gregory Y Lauwers
While the presence of intraepithelial lymphocytosis with surface epithelial damage is a unifying feature of lymphocytic colitis, there are non-classical features that create morphologic heterogeneity between cases. Limited data are available on the significance of these secondary histologic features. Cases of lymphocytic colitis diagnosed between 2002 and 2013 were identified using the Research Patient Data Registry of a tertiary referral center. Diagnostic biopsy slides were reviewed and evaluated for histologic features of lymphocytic colitis...
February 13, 2018: Human Pathology
https://www.readbyqxmd.com/read/29387389/oral-administration-of-salmon-cartilage-proteoglycan-extends-the-survival-of-allografts-in-mice
#15
Krisana Asano, Emiko Takahashi, Sayuri Yoshimura, Akio Nakane
Proteoglycan (PG) is a complex glycohydrate that is widely distributed in the extracellular matrix. Oral administration of PG extracted from salmon nasal cartilage has been reported to attenuate the severity and proinflammatory cytokine responses in mouse experimental colitis, autoimmune encephalomyelitis, collagen-induced arthritis and obesity-induced inflammation. In the present study, the effects of salmon nasal cartilage PG on skin allografts were investigated in a mouse model. Oral administration of PG prolonged the survival of skin grafts within 10 days of transplantation...
January 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29370359/smoking-is-associated-with-an-increased-risk-of-microscopic-colitis-results-from-two-large-prospective-cohort-studies-of-us-women
#16
Kristin E Burke, Ashwin N Ananthakrishnan, Paul Lochhead, Ola Olen, Jonas F Ludvigsson, James M Richter, Andrew T Chan, Hamed Khalili
Introduction: Long-term data on the influence of smoking on risk of microscopic colitis are limited. We therefore sought to examine and characterize the association between smoking and risk of incident microscopic colitis in two large prospective cohorts of women. Methods: We conducted a prospective study of 231,015 women enrolled in the Nurses' Health Study (NHS) and NHSII. Information regarding smoking, other lifestyle factors, and medications were collected biennially from 1976 to 2012 in NHS and 1989 to 2013 in NHSII...
January 23, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29336663/lactobacillus-acidophilus-improves-intestinal-inflammation-in-an-acute-colitis-mouse-model-by-regulation-of-th17-and-treg-cell-balance-and-fibrosis-development
#17
Jin-Sil Park, Jeong Won Choi, JooYeon Jhun, Ji Ye Kwon, Bo-In Lee, Chul Woo Yang, Sung-Hwan Park, Mi-La Cho
Disruption of the balance among the microbiota, epithelial cells, and resident immune cells in the intestine is involved in the pathogenesis of inflammatory bowel disease (IBD). Probiotics exert protective effects against IBD, and probiotic commensal Lactobacillus species are common inhabitants of the natural microbiota, especially in the gut. To investigate the effects of Lactobacillus acidophilus on the development of IBD, L. acidophilus was administered orally in mice with dextran sodium sulfate (DSS)-induced colitis...
March 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29317939/medical-treatment-for-microscopic-colitis-a-community-hospital-s-experience
#18
Abdallah Haidar, Savreet Kaur, Nancy Jackson, Jose Mari Parungao, Michael Piper, Alan Cutler
Background: Lymphocytic colitis (LC) is a chronic disorder characterized by watery diarrhea. This study sought to evaluate if LC recurs after therapy, and the time frame in which this occurs. Secondary objectives included length and type of therapy, drug-free intervals, and reasons for drug discontinuation. Methods: A retrospective chart review between January 1, 2008 and October 30, 2015 of patients with biopsy-confirmed lymphocytic, collagenous, or microscopic colitis was conducted...
December 2017: Gastroenterology Research
https://www.readbyqxmd.com/read/29250582/magnifying-advanced-endoscopy-in-collagenous-colitis-now-you-see
#19
EDITORIAL
Anastasios Koulaouzidis, Ervin Toth
No abstract text is available yet for this article.
November 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/29250581/magnifying-image-enhanced-endoscopy-for-collagenous-colitis
#20
Masaaki Kobayashi, Takahiro Hoshi, Shin-Ich Morita, Tsutomu Kanefuji, Takeshi Suda, Go Hasegawa, Shuji Terai
Background and study aims  We report a case series of 5 patients with collagenous colitis (CC) presenting with chronic watery diarrhea, who were subjected to magnifying, chromoendoscopy and narrow band imaging (NBI). Magnifying chromoendoscopy revealed whitish-clouded, honeycomb-like appearance at orifices of the crypts. NBI with high magnification revealed irregular caliber variation of the subepithelial capillary network. Presence of these features corresponded with histological characteristics of CC indicated by thickening of the subepithelial collagen layer...
November 2017: Endoscopy International Open
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