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https://www.readbyqxmd.com/read/27897155/diagnosis-and-management-of-microscopic-colitis
#1
REVIEW
Darrell S Pardi
Microscopic colitis (MC) is a relatively common cause of chronic watery diarrhea, especially in older persons. Associated symptoms, including abdominal pain and arthralgias, are common. The diagnosis is based upon characteristic histological findings in the presence of diarrhea. The two types of MC, collagenous and lymphocytic colitis, share similar clinical features, with the main difference being the presence or absence of a thickened subepithelial collagen band. There are several treatment options for patients with MC, although only budesonide has been well studied in multiple controlled clinical trials...
November 29, 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27870773/tofacitinib-response-in-juvenile-idiopathic-arthritis-jia-and-collagenous-colitis
#2
Bryon Tseng, Arash Amighi, Kara Bradford, Hanlin L Wang, Terri E Getzug, Ernest Brahn
No abstract text is available yet for this article.
December 2016: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/27789456/hydroxylases-regulate-intestinal-fibrosis-through-the-suppression-of-erk-mediated-tgf-%C3%AE-1-signaling
#3
Mario C Manresa, Murtaza M Tambuwala, Praveen Radhakrishnan, Jonathan M Harnoss, Eric Brown, Miguel A Cavadas, Ciara E Keogh, Alex Cheong, Kim E Barrett, Eoin P Cummins, Martin Schneider, Cormac T Taylor
Fibrosis is a complication of chronic inflammatory disorders such as inflammatory bowel disease (IBD), a condition which has limited therapeutic options and often requires surgical intervention. Pharmacologic inhibition of oxygen-sensing prolyl hydroxylases (PHD), which confer oxygen-sensitivity upon the hypoxia inducible factor (HIF) pathway, has recently been shown to have therapeutic potential in colitis, although the mechanisms involved remain unclear. Here, we investigated the impact of hydroxylase inhibition on inflammation-driven fibrosis in a murine colitis model...
October 27, 2016: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/27784958/towards-a-new-paradigm-of-microscopic-colitis-incomplete-and-variant-forms
#4
REVIEW
Danila Guagnozzi, Stefania Landolfi, Maria Vicario
Microscopic colitis (MC) is a chronic inflammatory bowel disease that has emerged in the last three decades as a leading cause of chronic watery diarrhoea. MC classically includes two main subtypes: lymphocytic colitis (LC) and collagenous colitis (CC). Other types of histopathological changes in the colonic mucosa have been described in patients with chronic diarrhoea, without fulfilling the conventional histopathological criteria for MC diagnosis. Whereas those unclassified alterations remained orphan for a long time, the use of the term incomplete MC (MCi) is nowadays universally accepted...
October 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27733667/association-between-proton-pump-inhibitors-and-microscopic-colitis-implications-for-practice-and-future-research
#5
Ernest H Law, Melissa Badowski, Yu-Ting Hung, Kimberly Weems, Angelica Sanchez, Todd A Lee
OBJECTIVE: Microscopic colitis (MC) is a chronic inflammatory disease of the colon that is characterized by chronic, watery, nonbloody diarrhea. Concern regarding a potential association between proton-pump inhibitors (PPIs) and MC has recently emerged. We sought to systematically review and summarize the evidence for the potential association between PPIs and MC. DATA SOURCES: We systematically searched EMBASE, MEDLINE, Cochrane Database of Systematic Reviews, International Pharmaceutical Abstracts, and Google Scholar using the terms proton-pump inhibitors (omeprazole, lansoprazole, dexlansoprazole, rabeprazole, pantoprazole, or esomeprazole), microscopic colitis, collagenous colitis, and lymphocytic colitis STUDY SELECTION: Full-text, English-language reports of case reports/series, observational studies, experimental studies, and systematic reviews/meta-analyses published between January 2000 to August 2016 were included...
October 12, 2016: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/27733383/intestinal-inflammation-without-weight-loss-decreases-bone-density-and-growth
#6
Regina Irwin, Sandi Raehtz, Narayanan Parameswaran, Laura R McCabe
Increasing evidence indicates a strong link between intestinal health and bone health. For example, inflammatory bowel disease can cause systemic inflammation, weight loss, and extra-intestinal manifestations, such as decreased bone growth and density. However, the effects of moderate intestinal inflammation without weight loss on bone health have never been directly examined; yet this condition is relevant not only to IBD but to conditions of increased intestinal permeability and inflammation, as seen with ingestion of high-fat diets, intestinal dysbiosis, irritable bowel syndrome, metabolic syndrome, and food allergies...
December 1, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/27725290/pseudomembranes-carpet-the-right-colon-due-to-collagenous-colitis
#7
Annika Resch, Andreas Eherer, Cord Langner
No abstract text is available yet for this article.
October 7, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27716080/collagenous-colitis-presenting-as-spontaneous-perforation-in-an-80%C3%A2-year-old-woman-report-of-a-case
#8
Andrew Mitchell, Alexandre Dugas
BACKGROUND: Perforation of the colon occurring during or shortly following colonoscopy or barium enema is a rare complication of collagenous colitis (CC). "Spontaneous" perforation in CC, in which no instigating factor is identified, is even less common, with only five cases reported to date. We report herein an additional case of spontaneous perforation in previously undiagnosed CC and review the clinical and pathological features of previously reported cases. CASE PRESENTATION: An 80 year old woman presented to the emergency department with abdominal pain preceded by approximately one month of frequent non-bloody diarrhea...
October 6, 2016: BMC Gastroenterology
https://www.readbyqxmd.com/read/27688814/multilocus-sequence-typing-of-campylobacter-concisus-from-danish-diarrheic-patients
#9
Hans Linde Nielsen, Henrik Nielsen, Mia Torpdahl
The emerging enteric pathogen Campylobacter concisus is associated with prolonged diarrhea and inflammatory bowel disease. Previous studies have shown that C. concisus strains are very genetically diverse. Nevertheless, C. concisus strains have been divided into two genomospecies, where GS1 strains have been isolated predominantly from healthy individuals, while the GS2 cluster consists of isolates primarily from diarrheic individuals. The aim of the present study was to determine the genetic diversity of C...
2016: Gut Pathogens
https://www.readbyqxmd.com/read/27671822/boswellic-acids-and-their-role-in-chronic-inflammatory-diseases
#10
H P T Ammon
: Boswellic acids, which are pentacyclic triterpenes belong to the active pharmacological compounds of the oleogum resin of different Boswellia species. In the resin, more than 12 different boswellic acids have been identified but only KBA and AKBA received significant pharmacological interest. Biological Activity: In an extract of the resin of Boswellia species multiple factors are responsible for the final outcome of a therapeutic effect, be it synergistic or antagonistic. Moreover, the anti-inflammatory actions of BAs are caused by different mechanisms of action...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27659673/incidence-clinical-presentation-and-associated-factors-of-microscopic-colitis-in-northern-france-a-population-based-study
#11
Mathurin Fumery, Mathieu Kohut, Corinne Gower-Rousseau, Alain Duhamel, Franck Brazier, Francoise Thelu, Francis Nagorniewicz, Francois Lamarche, Eric Nguyen-Khac, Charles Sabbagh, Julien Loreau, Jean-Frederic Colombel, Guillaume Savoye, Denis Chatelain, Jean-Louis Dupas
OBJECTIVE: To date, there are no epidemiological data on microscopic colitis (MC) in France. The aim of this study was to determine the incidence of MC in the Somme department in Northern France, to evaluate clinical characteristics, and to search for risk factors for both collagenous colitis (CC) and lymphocytic colitis (LC). DESIGN: Between January 1, 2005, and December 31, 2007, four pathology units in the Somme department recorded all new cases of MC diagnosed in patients living in the area...
September 22, 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/27620860/comparison-of-clinical-features-treatment-and-outcomes-of-collagenous-sprue-celiac-disease-and-collagenous-colitis
#12
Nan Lan, Bo Shen, Lisi Yuan, Xiuli Liu
BACKGROUND: Collagenous sprue (CS) is a rare form of enteropathy that had been reported to be associated with celiac disease (CD) and collagenous colitis (CC). The aim of our study was to compare the clinical features, treatments and outcomes of CS, CD, and CC. METHODS: All patients with histologic diagnosis of CS, CD or CC with complete clinical data were extracted from our pathology database between 1990 and 2015. Demographic and clinical features were recorded along with treatments and outcomes...
September 13, 2016: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27498142/oral-pirfenidone-protects-against-fibrosis-by-inhibiting-fibroblast-proliferation-and-tgf-%C3%AE-signaling-in-a-murine-colitis-model
#13
Guanwei Li, Jianan Ren, Qiongyuan Hu, Youming Deng, Guopu Chen, Kun Guo, Ranran Li, Yuan Li, Lei Wu, Gefei Wang, Guosheng Gu, Jieshou Li
Inflammatory bowel disease (IBD), particularly Crohn's disease, frequently causes intestinal fibrosis that ultimately leads to formation of strictures requiring bowel resection. Currently there is no effective antifibrotic therapy available for this disease. Pirfenidone is a small compound that has a broad spectrum of antifibrogenic effect and has been used for the treatment of fibrotic diseases in various organs. The present study aimed to investigate the antifibrogenic effect of pirfenidone in a dextran sulfate sodium (DSS)-induced murine colitis model...
October 1, 2016: Biochemical Pharmacology
https://www.readbyqxmd.com/read/27410685/pivotal-role-of-carbohydrate-sulfotransferase-15-in-fibrosis-and-mucosal-healing-in-mouse-colitis
#14
Kenji Suzuki, Somasundaram Arumugam, Junji Yokoyama, Yusuke Kawauchi, Yutaka Honda, Hiroki Sato, Yutaka Aoyagi, Shuji Terai, Kazuichi Okazaki, Yasuo Suzuki, Shuji Mizumoto, Kazuyuki Sugahara, Raja Atreya, Markus F Neurath, Kenichi Watanabe, Taishi Hashiguchi, Hiroyuki Yoneyama, Hitoshi Asakura
Induction of mucosal healing (MH) is an important treatment goal in inflammatory bowel disease (IBD). Although the molecular mechanisms underlying MH in IBD is not fully explored, local fibrosis would contribute to interfere mucosal repair. Carbohydrate sulfotransferase 15 (CHST15), which catalyzes sulfation of chondroitin sulfate to produce rare E-disaccharide units, is a novel mediator to create local fibrosis. Here we have used siRNA-based approach of silencing CHST15 in dextran sulfate sodium (DSS) induced colitis in mice, human colon fibroblasts and cancer cell lines...
2016: PloS One
https://www.readbyqxmd.com/read/27357113/good-s-syndrome-is-thymectomy-the-solution-case-report-and-literature-review
#15
Ahmed M Habib, Hilary Thornton, Wa Carrock Sewell, Mahmoud Loubani
Good's syndrome is thymoma accompanied by immunodeficiency. A 69-year-old woman presented with recurrent chest infections, hypogammaglobulinemia, and radiological features of a thymoma. Immunoglobulin replacement therapy was not tolerated prior to surgery. Postoperative recovery was uneventful, and a Masaoka stage II type AB thymoma was confirmed on histology. One-year follow-up revealed no recurrence of the thymoma but the patient remained hypogammaglobulinemic and developed collagenous colitis. She declined immunoglobulin replacement therapy but remains under follow-up...
September 2016: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/27343762/role-of-the-protein-annexin-a1-on-the-efficacy-of-anti-tnf-treatment-in-a-murine-model-of-acute-colitis
#16
Marina de Paula-Silva, Bibiana Elisabeth Barrios, Lisa Macció-Maretto, Angela Aparecida Sena, Sandra Helena Poliselli Farsky, Silvia Graciela Correa, Sonia Maria Oliani
TNF-α is involved in the mechanisms that initiate inflammatory bowel diseases (IBDs). Anti-TNF-α drugs, such as infliximab (IFX), cause non-responsiveness and side effects, indicating the need to investigate alternative therapies for these diseases. The anti-inflammatory protein, annexin A1 (AnxA1), has been associated with the protection of the gastrointestinal mucosa. To further address the role of endogenous AnxA1 on the TNF-α blockade efficacy in a murine model, we assessed colitis induced by Dextran Sulfate Sodium (DSS) in wild-type (WT) and AnxA1(-/-) Balb/c mice treated with IFX...
September 1, 2016: Biochemical Pharmacology
https://www.readbyqxmd.com/read/27309769/protective-effect-of-periplaneta-americana-extract-in-ulcerative-colitis-rats-induced-by-dinitrochlorobenzene-and-acetic-acid
#17
Na Li, Rongzhu Lu, Yuanyuan Yu, Ying Lu, Lu Huang, Juan Jin, Lidan Zhang, Jun Chen
CONTEXT: Periplaneta americana L. (Dictyoptera; Blattaria) has been traditional used to treat ulcers, burns and heart disease in southwestern China. Recent reports indicate that P. americana can be used as an alternative medicine in therapy of ulcerative colitis, but the mechanism involved remains obscure. OBJECTIVE: This study investigated the therapeutic effect of P. americana extract (PAE) in rat colitis and elucidated its potential mechanism. MATERIALS AND METHODS: Dinitrochlorobenzene and acetic acid-induced colitis rat model was applied...
June 16, 2016: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27302961/dw2007-ameliorates-colitis-and-rheumatoid-arthritis-in-mice-by-correcting-th17-treg-imbalance-and-inhibiting-nf-%C3%AE%C2%BAb-activation
#18
Su-Min Lim, Sang-Yun Lee, Jin-Ju Jeong, Hyun Sik Choi, Hwan Bong Chang, Dong-Hyun Kim
In the previous study, the rhizome mixture of Anemarrhena asphodeloides and Coptis chinensis (DW2007), improved TNBS-, oxazolone-, or DSS-induced colitis in mice by regulating macrophage activation. Therefore, to understand the effect of DW2007 on the T cell differentiation involved in the adaptive immunity, we measured its effect on both Th17 and Treg cell differentiation in splenocytes, in the lamina propria of mice with DSS-induced colitis (DIC), and in the spleens of mice with collagen-induced arthritis (CIA)...
November 1, 2016: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/27275091/multiorgan-chronic-inflammatory-hepatobiliary-pancreatic-murine-model-deficient-in-tumor-necrosis-factor-receptors-1-and-2
#19
Helieh S Oz
AIM: To provoke persistent/chronic multiorgan inflammatory response and to contribute to stones formation followed by fibrosis in hepatobiliary and pancreatic tissues. METHODS: Tumor necrosis factor receptors 1 and 2 (TNFR1/R2) deficient mice reared in-house were given dibutyltin dichloride (DBTC) twice within 10 d by oral gavage delivery. Sham control animals received vehicle treatment and naïve animals remained untreated throughout the study. Animals were monitored daily for symptoms of pain and discomfort...
June 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27271790/diagnosis-and-treatment-of-microscopic-colitis
#20
REVIEW
Ryuichi Okamoto, Mariko Negi, Syohei Tomii, Yoshinobu Eishi, Mamoru Watanabe
Microscopic colitis (MC) designates two types of chronic diarrhea diseases, which are lymphocytic colitis and collagenous colitis. The prevalence of microscopic colitis is increasing in both Western and Eastern countries, possibly due to the high incidence of colonoscopic survey in chronic diarrhea patients. Although the overall prognosis of MC patients is mostly good, it should be noted that appropriate diagnosis and choice of treatment is required to assure a good clinical outcome for MC patients. Also, a certain population of MC patients may take a severe and refractory clinical course, and thus require advanced clinical care using medications supported by less evidence...
August 2016: Clinical Journal of Gastroenterology
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