Jing Zhang, Hui Liu, Yang Shen, Dong Cheng, Hui Tang, Qi Zhang, Chao Li, Ming Liu, Wenhuan Yao, Rongrong Ran, Qingzhen Hou, Xiulan Zhao, Jia-Sheng Wang, Xiulan Sun, Tianliang Zhang, Jun Zhou
Aflatoxin B1 (AFB1 ) is a major mycotoxin contaminant showing in the environment and foods. In this study, the molecular initiating events (MIEs) of AFB1 -induced steatohepatitis were explored in mice and human cell model. We observed dose-dependent steatohepatitis in the AFB1 -treated mice, including triglyceride accumulation, fibrotic collagen secretion, enrichment of CD11b + and F4/80+ macrophages/Kupffer cells, cell death, lymphocytes clusters and remarkable atrophy areas. The gut barrier and gut-microbiota were also severely damaged after the AFB1 treatment and pre-conditioned colitis in the experimental mice aggravated the steatohepatitis phenotypes...
March 6, 2024: Science of the Total Environment