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Collagenous colitis

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https://www.readbyqxmd.com/read/28207769/role-of-glycogen-synthase-kinase-3%C3%AE-and-ppar-%C3%AE-on-epithelial-to-mesenchymal-transition-in-dss-induced-colorectal-fibrosis
#1
Jacopo Di Gregorio, Roberta Sferra, Silvia Speca, Antonella Vetuschi, Caroline Dubuquoy, Pierre Desreumaux, Simona Pompili, Loredana Cristiano, Eugenio Gaudio, Vincenzo Flati, Giovanni Latella
BACKGROUND: Intestinal fibrosis is characterized by abnormal production and deposition of extracellular matrix (ECM) proteins by activated myofibroblasts. The main progenitor cells of activated myofibroblasts are the fibroblasts and the epithelial cells, the latter through the epithelial-mesenchymal transition (EMT). AIM: To evaluate the action of the new PPAR-γ modulator, GED-0507-34 Levo (GED) on the expression of EMT associated and regulatory proteins such as TGF-β, Smad3, E-cadherin, Snail, ZEB1, β-catenin, and GSK-3β, in a mouse model of DSS-induced intestinal fibrosis...
2017: PloS One
https://www.readbyqxmd.com/read/28179109/mechanisms-of-defense-against-products-of-cysteine-catabolism-in-the-nematode-caenorhabditis-elegans
#2
Leonid Livshits, Arijit Kumar Chatterjee, Netanel Karbian, Rachel Abergel, Zohar Abergel, Einav Gross
Cysteine catabolism presents cells with a double-edged sword. On the one hand, cysteine degradation provides cells with essential molecules such as taurine and sulfide. The formation of sulfide in cells is thought to regulate important and diverse physiological processes including blood circulation, synaptic activity and inflammation. On the other hand, the catabolism of cysteine by gut microbiota can release high levels of sulfide that may underlie the development or relapse of ulcerative colitis, an inflammatory bowel disease affecting millions of people worldwide...
February 4, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28175009/p048-decreased-expression-of-aquaporins-in-colonic-biopsies-from-collagenous-colitis-patients-a-novel-diarrhoeal-pathomechanism
#3
A Holm, A Mancebo Giménez, V Loitto, E Vikström, K-E Magnusson, A Münch
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28130288/topical-timolol-for-the-treatment-of-pyoderma-gangrenosum
#4
Catarina Moreira, Sofia Lopes, Maria João Cruz, Filomena Azevedo
Treatment of pyoderma gangrenosum (PG) remains a challenge, and there are currently no specific or uniformly effective therapies. Although widespread or rapidly progressive disease often requires systemic treatment, localised and mild lesions may be effectively controlled with topical agents. The most frequently applied topical drugs are corticosteroids and calcineurin inhibitors. Recently, a patient with idiopathic PG of the lower limb was successfully treated with topical timolol and collagenase. Here, we report a case of a patient with collagenous colitis, ankylosing spondylitis and periumbilical PG...
January 27, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28119938/pseudomembranous-collagenous-colitis-a-case-of-not-so-microscopic-colitis
#5
Douglas Grunwald, Manisha Mehta, Sunil G Sheth
We present a 72-year-old male who developed progressive, watery diarrhea despite anti-motility agents. On colonoscopy, the mucosa was inflamed and covered with an exudate. Stool studies for Clostridium difficile and Escherichia coli were negative. Biopsies revealed pseudomembranous collagenous colitis, a rare form of microscopic colitis. His symptoms improved dramatically with budesonide therapy.
August 2016: ACG Case Reports Journal
https://www.readbyqxmd.com/read/28101837/drug-exposure-and-the-risk-of-microscopic-colitis-a-critical-update
#6
Alfredo J Lucendo
A variety of luminal antigens, including a wide range of drugs, have been associated with the still little-known pathophysiology of microscopic colitis (MC), with variable evidence suggesting causality. This article aims to review the aspects related to drugs as potential triggers of MC; to discuss the most commonly identified associations between drugs and MC; and to analyze the limitations of the studies currently available. A literature search was performed in PubMed combining the search terms 'drug exposure', 'drug consumption', and 'risk factors' with 'microscopic colitis', 'lymphocytic colitis', and 'collagenous colitis', with no language restrictions...
January 18, 2017: Drugs in R&D
https://www.readbyqxmd.com/read/28044228/reduced-il-37-production-increases-spontaneous-chemokine-expressions-in-colon-epithelial-cells
#7
Sezin Günaltay, Mohammed Ghiboub, Olof Hultgren, Elisabeth Hultgren Hörnquist
BACKGROUND AND AIM: Microscopic colitis, comprising collagenous colitis and lymphocytic colitis, is a common cause of chronic diarrhea. Previously, we showed enhanced chemokine productions in microscopic colitis patients, indicating dysregulated immune cell chemotaxis in the immunopathogenesis. We also showed decreased mRNA of IL-37, mainly regarded as an anti-inflammatory cytokine, in the colonic mucosa of these patients, potentially an important factor for the chronicity of the colitis...
January 2, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28001266/microscopic-colitis-a-literature-review
#8
Ana Paula Hamer Sousa Clara, Flávia Drago Magnago, Juliana Neves Ferreira, Thais Gagno Grillo
Microscopic colitis (MC) refers to chronic inflammation of the colon which is characterized by histologic changes at the level of a radiologically and endoscopically normal mucosa. It is a common cause of chronic non-bloody diarrhea that occurs primarily in older individuals; however, there are few studies in the literature with strong scientific evidence compared to other inflammatory bowel diseases (IBD), which limits the knowledge of physicians and pathologists. This article aims to review the information on MC, describing diagnostic methods and drugs available for treatment...
December 2016: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/27897155/diagnosis-and-management-of-microscopic-colitis
#9
REVIEW
Darrell S Pardi
Microscopic colitis (MC) is a relatively common cause of chronic watery diarrhea, especially in older persons. Associated symptoms, including abdominal pain and arthralgias, are common. The diagnosis is based upon characteristic histological findings in the presence of diarrhea. The two types of MC, collagenous and lymphocytic colitis, share similar clinical features, with the main difference being the presence or absence of a thickened subepithelial collagen band. There are several treatment options for patients with MC, although only budesonide has been well studied in multiple controlled clinical trials...
November 29, 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27870773/tofacitinib-response-in-juvenile-idiopathic-arthritis-jia-and-collagenous-colitis
#10
Bryon Tseng, Arash Amighi, Kara Bradford, Hanlin L Wang, Terri E Getzug, Ernest Brahn
No abstract text is available yet for this article.
December 2016: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/27789456/hydroxylases-regulate-intestinal-fibrosis-through-the-suppression-of-erk-mediated-tgf-%C3%AE-1-signaling
#11
Mario C Manresa, Murtaza M Tambuwala, Praveen Radhakrishnan, Jonathan M Harnoss, Eric Brown, Miguel A Cavadas, Ciara E Keogh, Alex Cheong, Kim E Barrett, Eoin P Cummins, Martin Schneider, Cormac T Taylor
Fibrosis is a complication of chronic inflammatory disorders such as inflammatory bowel disease, a condition which has limited therapeutic options and often requires surgical intervention. Pharmacologic inhibition of oxygen-sensing prolyl hydroxylases, which confer oxygen sensitivity upon the hypoxia-inducible factor pathway, has recently been shown to have therapeutic potential in colitis, although the mechanisms involved remain unclear. Here, we investigated the impact of hydroxylase inhibition on inflammation-driven fibrosis in a murine colitis model...
December 1, 2016: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/27784958/towards-a-new-paradigm-of-microscopic-colitis-incomplete-and-variant-forms
#12
REVIEW
Danila Guagnozzi, Stefania Landolfi, Maria Vicario
Microscopic colitis (MC) is a chronic inflammatory bowel disease that has emerged in the last three decades as a leading cause of chronic watery diarrhoea. MC classically includes two main subtypes: lymphocytic colitis (LC) and collagenous colitis (CC). Other types of histopathological changes in the colonic mucosa have been described in patients with chronic diarrhoea, without fulfilling the conventional histopathological criteria for MC diagnosis. Whereas those unclassified alterations remained orphan for a long time, the use of the term incomplete MC (MCi) is nowadays universally accepted...
October 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27733667/association-between-proton-pump-inhibitors-and-microscopic-colitis-implications-for-practice-and-future-research
#13
REVIEW
Ernest H Law, Melissa Badowski, Yu-Ting Hung, Kimberly Weems, Angelica Sanchez, Todd A Lee
OBJECTIVE: Microscopic colitis (MC) is a chronic inflammatory disease of the colon that is characterized by chronic, watery, nonbloody diarrhea. Concern regarding a potential association between proton-pump inhibitors (PPIs) and MC has recently emerged. We sought to systematically review and summarize the evidence for the potential association between PPIs and MC. DATA SOURCES: We systematically searched EMBASE, MEDLINE, Cochrane Database of Systematic Reviews, International Pharmaceutical Abstracts, and Google Scholar using the terms proton-pump inhibitors (omeprazole, lansoprazole, dexlansoprazole, rabeprazole, pantoprazole, or esomeprazole), microscopic colitis, collagenous colitis, and lymphocytic colitis STUDY SELECTION: Full-text, English-language reports of case reports/series, observational studies, experimental studies, and systematic reviews/meta-analyses published between January 2000 to August 2016 were included...
October 12, 2016: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/27733383/intestinal-inflammation-without-weight-loss-decreases-bone-density-and-growth
#14
Regina Irwin, Sandi Raehtz, Narayanan Parameswaran, Laura R McCabe
Increasing evidence indicates a strong link between intestinal health and bone health. For example, inflammatory bowel disease can cause systemic inflammation, weight loss, and extra-intestinal manifestations, such as decreased bone growth and density. However, the effects of moderate intestinal inflammation without weight loss on bone health have never been directly examined; yet this condition is relevant not only to IBD but to conditions of increased intestinal permeability and inflammation, as seen with ingestion of high-fat diets, intestinal dysbiosis, irritable bowel syndrome, metabolic syndrome, and food allergies...
December 1, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/27725290/pseudomembranes-carpet-the-right-colon-as-a-result-of-collagenous-colitis
#15
Annika Resch, Andreas Eherer, Cord Langner
No abstract text is available yet for this article.
October 8, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27716080/collagenous-colitis-presenting-as-spontaneous-perforation-in-an-80%C3%A2-year-old-woman-report-of-a-case
#16
Andrew Mitchell, Alexandre Dugas
BACKGROUND: Perforation of the colon occurring during or shortly following colonoscopy or barium enema is a rare complication of collagenous colitis (CC). "Spontaneous" perforation in CC, in which no instigating factor is identified, is even less common, with only five cases reported to date. We report herein an additional case of spontaneous perforation in previously undiagnosed CC and review the clinical and pathological features of previously reported cases. CASE PRESENTATION: An 80 year old woman presented to the emergency department with abdominal pain preceded by approximately one month of frequent non-bloody diarrhea...
October 6, 2016: BMC Gastroenterology
https://www.readbyqxmd.com/read/27688814/multilocus-sequence-typing-of-campylobacter-concisus-from-danish-diarrheic-patients
#17
Hans Linde Nielsen, Henrik Nielsen, Mia Torpdahl
The emerging enteric pathogen Campylobacter concisus is associated with prolonged diarrhea and inflammatory bowel disease. Previous studies have shown that C. concisus strains are very genetically diverse. Nevertheless, C. concisus strains have been divided into two genomospecies, where GS1 strains have been isolated predominantly from healthy individuals, while the GS2 cluster consists of isolates primarily from diarrheic individuals. The aim of the present study was to determine the genetic diversity of C...
2016: Gut Pathogens
https://www.readbyqxmd.com/read/27671822/boswellic-acids-and-their-role-in-chronic-inflammatory-diseases
#18
H P T Ammon
: Boswellic acids, which are pentacyclic triterpenes belong to the active pharmacological compounds of the oleogum resin of different Boswellia species. In the resin, more than 12 different boswellic acids have been identified but only KBA and AKBA received significant pharmacological interest. Biological Activity: In an extract of the resin of Boswellia species multiple factors are responsible for the final outcome of a therapeutic effect, be it synergistic or antagonistic. Moreover, the anti-inflammatory actions of BAs are caused by different mechanisms of action...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27659673/incidence-clinical-presentation-and-associated-factors-of-microscopic-colitis-in-northern-france-a-population-based-study
#19
Mathurin Fumery, Mathieu Kohut, Corinne Gower-Rousseau, Alain Duhamel, Franck Brazier, Francoise Thelu, Francis Nagorniewicz, Francois Lamarche, Eric Nguyen-Khac, Charles Sabbagh, Julien Loreau, Jean-Frederic Colombel, Guillaume Savoye, Denis Chatelain, Jean-Louis Dupas
OBJECTIVE: To date, there are no epidemiological data on microscopic colitis (MC) in France. The aim of this study was to determine the incidence of MC in the Somme department in Northern France, to evaluate clinical characteristics, and to search for risk factors for both collagenous colitis (CC) and lymphocytic colitis (LC). DESIGN: Between January 1, 2005, and December 31, 2007, four pathology units in the Somme department recorded all new cases of MC diagnosed in patients living in the area...
September 22, 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/27620860/comparison-of-clinical-features-treatment-and-outcomes-of-collagenous-sprue-celiac-disease-and-collagenous-colitis
#20
Nan Lan, Bo Shen, Lisi Yuan, Xiuli Liu
BACKGROUND: Collagenous sprue (CS) is a rare form of enteropathy that had been reported to be associated with celiac disease (CD) and collagenous colitis (CC). The aim of our study was to compare the clinical features, treatments, and outcomes of CS, CD, and CC. METHODS: All patients with histologic diagnosis of CS, CD, or CC with complete clinical data were extracted from our pathology database between 1990 and 2015. Demographic and clinical features were recorded along with treatments and outcomes...
January 2017: Journal of Gastroenterology and Hepatology
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