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Lymphocytic colitis

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https://www.readbyqxmd.com/read/28204866/vedolizumab-treatment-for-immune-checkpoint-inhibitor-induced-enterocolitis
#1
Viktoria Bergqvist, Erik Hertervig, Peter Gedeon, Marija Kopljar, Håkan Griph, Sara Kinhult, Ana Carneiro, Jan Marsal
Immune checkpoint inhibitors (ICPI), such as ipilimumab [anti-cytotoxic T-lymphocyte antigen-4 (CTLA-4) antibody] and nivolumab or pembrolizumab [anti-programmed cell death protein-1 (PD-1) antibodies], improve survival in several cancer types. Since inhibition of CTLA-4 or PD-1 leads to non-selective activation of the immune system, immune-related adverse events (irAEs) are frequent. Enterocolitis is a common irAE, currently managed with corticosteroids and, if necessary, anti-tumor necrosis factor-α therapy...
February 15, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/28177967/the-neutralizing-and-targeting-properties-of-a-new-set-of-%C3%AE-4%C3%AE-7-specific-antibodies-are-influenced-by-their-isotype
#2
Alexandre Girard, Katija Jelicic, Don Van Ryk, Nicolas Rochereau, Claudia Cicala, James Arthos, Christian Genin, Bernard Verrier, Stephanie Laurant, Diane Razanajaoana-Doll, Pin Jean-Jacques, Stéphane Paul
The homing of lymphocytes to mucosa is mainly controlled by α4β7 integrin, and it is amplified during gut chronic inflammation, as occurs with HIV and/or Inflammatory Bowel Diseases. We designed and applied an improved immunization strategy based on an innovative selection process to isolate new α4β7 lymphocyte-specific mAbs that are able to prevent their migration into inflamed gut tissues and/or to counteract HIV infection in vitro. Firstly, five mAbs (one IgA, one IgM, and four IgGs) were selected based on their capacity to recognize α4 or β7 homodimers and α4β7 heterodimers in transfected human cells...
February 7, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28172795/p427-neutrophil-to-lymphocyte-ration-in-ulcerative-colitis-predicts-sustained-response-to-infliximab
#3
Y Nishida, S Hosomi, K Watanabe, T Yukawa, K Otani, Y Nagami, F Tanaka, K Taira, N Kamata, M Shiba, H Yamagami, T Tanigawa, T Watanabe, K Tominaga, Y Fujiwara
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172589/p014-mucosal-lymphocyte-subsets-in-ulcerative-colitis-at-diagnosis-and-during-follow-up
#4
C Smids, C Horjus Talabur Horje, M Groenen, E van Koolwijk, P Wahab, E van Lochem
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172476/p208-long-term-follow-up-of-lymphocytic-colitis-patients
#5
G Mohamed, P Crotty, D McNamara, N Breslin, B M Ryan
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28164626/expression-of-cd200r1-and-its-ligand-cd200-on-t-helper-lymphocytes-of-pediatric-patients-with-ulcerative-colitis-and-crohn-s-disease
#6
Mohamed F Elshal, Alia M Aldahlawi, Omar I Saadah, J Philip Mccoy
BACKGROUND: CD200 and its receptor CD200R are both type I membrane glycoproteins that modulate the activity of myeloid and lymphoid cells, and their interaction is functionally important in the suppression of effector T-cell responses by regulatory T-cells. We aimed to investigate the extent of expression of CD200 and CD200R1 on CD4+ T-cells in blood of children with ulcerative colitis (UC) and Crohn's disease (CD) and to explore their correlations with effector T cell subsets, regulatory T cells (Treg), and routine clinical and serological markers...
August 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28138755/epithelial-barrier-dysfunction-in-lymphocytic-colitis-through-cytokine-dependent-internalization-of-claudin-5-and-8
#7
Christian Barmeyer, Irene Erko, Karem Awad, Anja Fromm, Christian Bojarski, Svenja Meissner, Christoph Loddenkemper, Martin Kerick, Britta Siegmund, Michael Fromm, Michal R Schweiger, Jörg-Dieter Schulzke
BACKGROUND: Watery diarrhea is the cardinal symptom of lymphocytic colitis (LC). We have previously shown that colonic Na malabsorption is one of the major pathologic alterations of LC and found evidence for an epithelial barrier defect. On these grounds, this study aimed to identify the inherent mechanisms of this epithelial barrier dysfunction and its regulatory features. METHODS: Epithelial resistance (R (epi)) was determined by one-path impedance spectroscopy and (3)H-mannitol fluxes were performed on biopsies from sigmoid colon in miniaturized Ussing chambers...
January 30, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28138449/budesonide-related-iatrogenic-cushing-s-syndrome-in-microscopic-colitis
#8
Kartikeya Tripathi, Thomas Dunzendorfer
Budesonide is the treatment of choice for microscopic colitis because of its excellent risk to benefit ratio. It is a potent, well-absorbed corticosteroid, but because of a high rate of first-pass metabolism in the liver, its systemic bioavailability is low. It has fewer corticosteroid-related adverse effects than prednisone, and adrenal suppression is considered to be rare. We present a middle-aged woman with lymphocytic colitis whose symptoms responded to budesonide but developed budesonide-related iatrogenic Cushing's syndrome...
2017: ACG Case Reports Journal
https://www.readbyqxmd.com/read/28129697/rituximab-induced-crohn-s-disease
#9
Poornima Varma, Julianne Falconer, Ahmad Aga, H Miles Prince, Stephen Pianko
The use of rituximab has significantly improved outcomes in patients with haematological malignancies and autoimmune disease. There are reports of rituximab-associated ulcerative colitis; however, we report for the first time, two cases of rituximab-induced Crohn's disease in elderly patients treated for lymphoma. Both patients had evidence of inflammation, ulceration, and granulomas consistent with Crohn's disease, and responded well to immunosuppression. The association of rituximab and ileocolitis suggests a protective effect of CD20 + lymphocytes in the gut, and implicates their depletion to the development and exacerbation of inflammatory bowel disease...
January 27, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28128877/endoscopic-findings-of-ipilimumab-induced-colitis
#10
Tatsunori Satoh, Kazuya Ohno, Takafumi Kurokami
Ipilimumab is a fully humanized monoclonal antibody targeting inhibitory cytotoxic T-lymphocyte-associated antigen-4 on T cells, thereby enhancing antitumor immunity.(1) While ipilimumab has significant therapeutic benefit, it induces hypersensitivity reactions in some targeted organs. Ipilimumab-induced colitis (IiC) is one such hypersensitivity reaction, clinically manifesting as colitis.(2) Colonoscopy is helpful in diagnosing IiC. The macroscopic and microscopic features of IiC include friable erythematous mucosa and ulcers with an absent vascular pattern...
January 27, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28124779/a-lactic-acid-bacterium-isolated-from-kimchi-ameliorates-intestinal-inflammation-in-dss-induced-colitis
#11
Jin-Soo Park, Inseong Joe, Paul Daong Rhee, Choon-Soo Jeong, Gajin Jeong
Some species of lactic acid bacteria have been shown to be beneficial in inflammatory bowel disease (IBD). In the present study, a strain of lactic acid bacterium (Lactobacillus paracasei LS2) was isolated from the Korean food, kimchi, and was shown to inhibit the development of experimental colitis induced by dextran sulfate sodium (DSS). To investigate the role of LS2 in IBD, mice were fed DSS in drinking water for seven days along with LS2 bacteria which were administered intragastrically to some of the mice, while phosphate- buffered saline (PBS) was administered to others (the controls)...
January 26, 2017: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/28120851/regulation-of-il-12p40-by-hif-controls-th1-th17-responses-to-prevent-mucosal-inflammation
#12
E Marks, C Naudin, G Nolan, B J Goggins, G Burns, S W Mateer, J K Latimore, K Minahan, M Plank, P S Foster, R Callister, M Veysey, M M Walker, N J Talley, G Radford-Smith, S Keely
Intestinal inflammatory lesions are inherently hypoxic, due to increased metabolic demands created by cellular infiltration and proliferation, and reduced oxygen supply due to vascular damage. Hypoxia stabilizes the transcription factor hypoxia-inducible factor-1α (HIF) leading to a coordinated induction of endogenously protective pathways. We identified IL12B as a HIF-regulated gene and aimed to define how the HIF-IL-12p40 axis influenced intestinal inflammation. Intestinal lamina propria lymphocytes (LPL) were characterized in wild-type and IL-12p40(-/-) murine colitis treated with vehicle or HIF-stabilizing prolyl-hydroxylase inhibitors (PHDi)...
January 25, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/28118483/meta-analysis-of-the-risk-of-immune-related-adverse-events-with-anti-cytotoxic-t-lymphocyte-associated-antigen-4-and-anti-programmed-death-1-therapies
#13
Yuga Komaki, Fukiko Komaki, Akihiro Yamada, Dejan Micic, Akio Ido, Atsushi Sakuraba
We assessed the risks of immune-related adverse events with anti-cytotoxic T-lymphocyte-associated antigen 4 (CTLA4) and anti-programmed death 1 (PD1) therapies by meta-analysis. Twenty-one studies including 11,144 patients were found. Anti-CTLA4 therapy was associated with a significantly higher risk of overall immune-related adverse events, diarrhea, immune-related colitis, pruritus and rash compared to control therapies (relative risk (RR) = 2.43, 2.10, 11.39, 3.88, 3.87, 95% confidence interval (CI) = 1...
January 24, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28101837/drug-exposure-and-the-risk-of-microscopic-colitis-a-critical-update
#14
Alfredo J Lucendo
A variety of luminal antigens, including a wide range of drugs, have been associated with the still little-known pathophysiology of microscopic colitis (MC), with variable evidence suggesting causality. This article aims to review the aspects related to drugs as potential triggers of MC; to discuss the most commonly identified associations between drugs and MC; and to analyze the limitations of the studies currently available. A literature search was performed in PubMed combining the search terms 'drug exposure', 'drug consumption', and 'risk factors' with 'microscopic colitis', 'lymphocytic colitis', and 'collagenous colitis', with no language restrictions...
January 18, 2017: Drugs in R&D
https://www.readbyqxmd.com/read/28095507/choline-deficiency-causes-colonic-type-ii-natural-killer-t-nkt-cell-loss-and-alleviates-murine-colitis-under-type-i-nkt-cell-deficiency
#15
Shintaro Sagami, Yoshitaka Ueno, Shinji Tanaka, Akira Fujita, Hiroaki Niitsu, Ryohei Hayashi, Hideyuki Hyogo, Takao Hinoi, Yasuhiko Kitadai, Kazuaki Chayama
Serum levels of choline and its derivatives are lower in patients with inflammatory bowel disease (IBD) than in healthy individuals. However, the effect of choline deficiency on the severity of colitis has not been investigated. In the present study, we investigated the role of choline deficiency in dextran sulfate sodium (DSS)-induced colitis in mice. Methionine-choline-deficient (MCD) diet lowered the levels of type II natural killer T (NKT) cells in the colonic lamina propria, peritoneal cavity, and mesenteric lymph nodes, and increased the levels of type II NKT cells in the livers of wild-type B6 mice compared with that in mice fed a control (CTR) diet...
2017: PloS One
https://www.readbyqxmd.com/read/28076386/neutrophil-to-lymphocyte-ratio-for-predicting-loss-of-response-to-infliximab-in-ulcerative-colitis
#16
Yu Nishida, Shuhei Hosomi, Hirokazu Yamagami, Tomomi Yukawa, Koji Otani, Yasuaki Nagami, Fumio Tanaka, Koichi Taira, Noriko Kamata, Tetsuya Tanigawa, Masatsugu Shiba, Kenji Watanabe, Toshio Watanabe, Kazunari Tominaga, Yasuhiro Fujiwara
OBJECTIVES: Neutrophil-to-lymphocyte ratio (NLR) has been used to determine the outcome in malignancies and coronary heart disease. Some reports considered the value of NLR as a predictor of response to infliximab in patients with Crohn's disease or rheumatoid arthritis; however, no similar studies have been reported for ulcerative colitis (UC). This study aimed to evaluate the clinical significance of the baseline NLR in patients with UC treated by infliximab. MATERIALS AND METHODS: Patients with moderate-to-severe active UC who received the first infliximab infusion in our hospital between 2010 and 2015, who showed clinical response during the induction period, were retrospectively evaluated for long-term outcomes and risk factors for loss of response (LOR) during infliximab maintenance therapy...
2017: PloS One
https://www.readbyqxmd.com/read/28063246/exacerbation-caused-by-5-asa-intolerance-in-children-with-ulcerative-colitis
#17
Hirotaka Shimizu, Katsuhiro Arai, Julian Tang, Kenji Hosoi, Rie Funayama
BACKGROUND: 5-aminosalicylate (5-ASA) is widely used as the first-line drug for ulcerative colitis (UC). 5-ASA is mostly a safe and effective drug, but it can bring about exacerbation due to 5-ASA intolerance. 5-ASA intolerance can be confusing and it can mislead physicians to consider unnecessary treatment escalation plan including corticosteroid (CS), biologics, or even surgery. In spite of the clinical importance of 5-ASA intolerance, there have been few publications about its incidence, clinical features, and diagnosis...
January 7, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28049094/aryl-hydrocarbon-receptor-activation-modulates-cd8%C3%AE-%C3%AE-tcr%C3%AE-%C3%AE-iels-and-suppression-of-colitis-manifestations-in-mice
#18
Weigang Chen, Aimin Pu, Baifa Sheng, Zhicao Zhang, Liangzi Li, Zhongze Liu, Qimeng Wang, Xiang Li, Yuanhang Ma, Min Yu, Lihua Sun, Yuan Qiu, Hua Yang
BACKGROUND: This research is dedicated to investigating the effects and potential mechanism of action of the aryl hydrocarbon receptor on the intestinal mucosal immune system in dextran sulfate sodium (DSS)-induced colitis. METHODS: Colitis was induced by the administration of 3% DSS to wild-type C57BL/6J mice for 7days. 6-formylindolo(3, 2-b)carbazole (FICZ), an endogenous agonist of the aryl hydrocarbon receptor (AhR), was given intraperitoneally on a daily basis beginning 2days after the start of DSS administration...
December 31, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28045023/meta-analytic-bayesian-model-for-differentiating-intestinal-tuberculosis-from-crohn-s-disease
#19
REVIEW
Julajak Limsrivilai, Andrew B Shreiner, Ananya Pongpaibul, Charlie Laohapand, Rewat Boonanuwat, Nonthalee Pausawasdi, Supot Pongprasobchai, Sathaporn Manatsathit, Peter D R Higgins
OBJECTIVES: Distinguishing intestinal tuberculosis (ITB) from Crohn's disease (CD) is difficult, although studies have reported clinical, endoscopic, imaging, and laboratory findings that help to differentiate these two diseases. We aimed to produce estimates of the predictive power of these findings and construct a comprehensive model to predict the probability of ITB vs. CD. METHODS: A systematic literature search for studies differentiating ITB from CD was conducted in MEDLINE, PUBMED, and EMBASE from inception until September 2015...
January 3, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28044228/reduced-il-37-production-increases-spontaneous-chemokine-expressions-in-colon-epithelial-cells
#20
Sezin Günaltay, Mohammed Ghiboub, Olof Hultgren, Elisabeth Hultgren Hörnquist
BACKGROUND AND AIM: Microscopic colitis, comprising collagenous colitis and lymphocytic colitis, is a common cause of chronic diarrhea. Previously, we showed enhanced chemokine productions in microscopic colitis patients, indicating dysregulated immune cell chemotaxis in the immunopathogenesis. We also showed decreased mRNA of IL-37, mainly regarded as an anti-inflammatory cytokine, in the colonic mucosa of these patients, potentially an important factor for the chronicity of the colitis...
January 2, 2017: Digestive Diseases and Sciences
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