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Lymphocytic esophagitis

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https://www.readbyqxmd.com/read/27889946/combined-fibrinogen-and-neutrophil-lymphocyte-ratio-as-a-prognostic-marker-of-advanced-esophageal-squamous-cell-carcinoma
#1
Takashi Kijima, Takaaki Arigami, Yasuto Uchikado, Yoshikazu Uenosono, Yoshiaki Kita, Tetsuhiro Owaki, Shinichiro Mori, Hiroshi Kurahara, Yuko Kijima, Hiroshi Okumura, Kousei Maemura, Sumiya Ishigami, Shoji Natsugoe
Patients with advanced esophageal squamous cell carcinoma (ESCC) is received chemoradiotherapy or chemotherapy for clinical management. However, it is difficult to predict tumor response and prognosis using blood markers before starting treatments. The purpose of this study was to investigate the pre-treatment plasma fibrinogen and neutrophil-lymphocyte ratio (NLR) in patients with advanced ESCC treated with chemoradiotherapy or chemotherapy, and to assess the clinical utility of a combined score using these blood markers, named as the F-NLR (fibrinogen and NLR) score, as a predictor of tumor response and prognosis...
November 27, 2016: Cancer Science
https://www.readbyqxmd.com/read/27878270/alteration-of-histone-h3-lysine-9-dimethylation-in-peripheral-white-blood-cells-of-septic-patients-with-trauma-and-cancer
#2
Linghui Jiang, Yiqin Wang, Duming Zhu, Zhanggang Xue, Hailei Mao
The present study aimed to investigate the clinical significance of histone methylation in sepsis. A total of 43 blood samples from trauma and esophageal cancer patients with or without sepsis were collected. Immunofluorescence staining of isolated peripheral white blood cells (WBCs) was conducted. Co‑stained 293T cells served as a reference, to allow the levels of histone methylation in different types of WBCs from patients to be determined. Immunostaining analyses revealed different levels of histone 3 lysine 9 dimethylation (H3K9me2) in neutrophils (Neu), lymphocytes (Lym), and monocytes (Mon) from trauma patients...
November 22, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27868286/a-high-number-of-stromal-tumor-infiltrating-lymphocytes-is-a-favorable-independent-prognostic-factor-in-m0-stages-i-iii-esophageal-squamous-cell-carcinoma
#3
Jing Li, Yang Tang, Liu Huang, Qianqian Yu, Guangyuan Hu, Yanmei Zou, Xianglin Yuan
Esophageal cancer is a highly invasive tumor with a poor prognosis. Lymphocytes play an important role in systemic immune responses, but their role in cancers varies depending on the specific tumor microenvironment. The aim of this study was to provide evidence for tumor-infiltrating lymphocytes (TILs) as a prognostic biomarker in esophageal squamous cell carcinoma. TIL analysis was retrospectively performed on full-face hematoxylin and eosin-stained sections from 127 patients. A majority (92.6%) of tumors had at least 10% stromal TILs (sTILs) (range, 10%-90%), and 84...
November 21, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/27852044/preoperative-blood-routine-markers-and-prognosis-of-esophageal-squamous-cell-carcinoma-the-fujian-prospective-investigation-of-cancer-fiesta-study
#4
Dan Hu, Xiandong Lin, Yan Chen, Qing Chang, Gang Chen, Chao Li, Hejun Zhang, Zhaolei Cui, Binying Liang, Wenhui Jiang, Kaida Ji, Jun Huang, Feng Peng, Xiongwei Zheng, Wenquan Niu
This prospective study was designed to investigate the prognosis of preoperative blood-routine markers for esophageal cancer mortality by using data from the ongoing Fujian prospective investigation of cancer (FIESTA) study. Patients who received three-field lymphadenectomy for esophageal cancer between 2000 and 2010 were enrolled. Of 2535 patients with complete survival data, esophageal squamous cell carcinoma (ESCC) accounted for 94.5% (n = 2396). Here, only ESCC patients were analyzed, with the median follow-up time of 38...
November 11, 2016: Oncotarget
https://www.readbyqxmd.com/read/27804027/prognostic-factors-for-locoregional-recurrence-in-patients-with-thoracic-esophageal-squamous-cell-carcinoma-treated-with-radical-two-field-lymph-node-dissection-results-from-long-term-follow-up
#5
ShiLiang Liu, Simone Anfossi, Bo Qiu, YuZhen Zheng, MuYan Cai, Jia Fu, Hong Yang, Qing Liu, ZhaoLin Chen, JianHua Fu, MengZhong Liu, Jared K Burks, Steven H Lin, James Reuben, Hui Liu
OBJECTIVE: To aim of this study was to determine the clinical and biological prognostic factors for locoregional recurrence (LRR) in patients with thoracic esophageal squamous cell carcinoma (ESCC) undergoing radical two-field lymph node dissection (2FLD). METHODS: A total of 462 patients diagnosed with thoracic ESCC underwent radical esophagectomy between March 2001 and May 2010 at Sun Yat-Sen University Cancer Center. Clinical characteristics, CD44 expression, and tumor-infiltrating lymphocyte (TIL) levels were evaluated in 198 patients who underwent R0 dissection with long-term follow-up...
November 1, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27789959/sensitivity-value-of-hematological-markers-in-patients-receiving-chemoradiotherapy-for-esophageal-squamous-cell-carcinoma
#6
Shan Zhu, Chuan-Wang Miao, Zhong-Tang Wang, Li Peng, Baosheng Li
BACKGROUND: Hematological markers of the systemic inflammatory response (SIR) including the neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and the combination of NLR with PLR (CNP) are associated with prognosis of patients with esophageal squamous cell carcinoma (ESCC). However, their value in predicting the sensitivity to chemoradiotherapy in patients with ESCC is unclear. The aim of this study was to investigate whether these markers can be used as sensitivity predictors for chemoradiotherapy in patients with ESCC...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27747091/the-promise-of-pd-1-inhibitors-in-gastro-esophageal-cancers-microsatellite-instability-vs-pd-l1
#7
Zhaohui Jin, Harry H Yoon
Preliminary clinical studies of anti-programmed cell death-1 (anti-PD-1) therapy in gastro-esophageal cancers have suggested promising single-agent activity. In patients who received prior treatment for advanced disease, pembrolizumab has been associated with a response rate of 20% in programmed cell death-1 ligand 1 (PD-L1)-positive tumors, and nivolumab with a response rate of 12% in unselected tumors. Both agents yielded a median duration of response lasting ~6-7 months. PD-L1 expression and microsatellite instability (MSI) have emerged as potential predictive markers for PD-1/PD-L1 blockade...
October 2016: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/27741346/candida-esophagitis-associated-with-mycophenolate-mofetil-treatment-of-atopic-dermatitis
#8
Anna Kurayev, Alice B Gottlieb
OBJECTIVE: To describe a case in which a patient developed Candida esophagitis (CE) after treatment of atopic dermatitis (AD) with mycophenolate mofetil (MMF) for 22 months. CASE SUMMARY: A 59-year-old Caucasian female with long-standing history of AD successfully treated with MMF presented to the dermatology clinic for follow-up appointment with 3 months' history of projectile vomiting, choking, and trouble swallowing. Patient underwent esophagogastroduodenoscopy (EGD) that demonstrated whitish plaques in esophagus consistent with CE, which was confirmed by biopsy and cytology...
October 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/27741060/elevated-serum-tissue-transglutaminase-antibodies-in-children-with-eosinophilic-esophagitis
#9
Anna K Le Fevre, Marjorie M Walker, Amir Hadjiashrafy, Rani Bhatia, Joerg Mattes, Nicholas J Talley, Scott Nightingale
OBJECTIVES: This study compared the clinical and histopathological characteristics of children with EoE and elevated anti-transglutaminase (TTG Ab) with those with EoE and normal TTG Ab titres. METHODS: Single center chart and blinded histopathological review of patients diagnosed with EoE over a four-year period, who had esophageal and duodenal biopsies taken at time of endoscopy, and TTG Ab measured within 6 months of biopsy. Patients with histology-proven CD were excluded...
October 12, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27703488/personalized-kampo-medicine-facilitated-both-cytotoxic-t-lymphocyte-response-and-clinical-benefits-induced-by-personalized-peptide-vaccination-for-advanced-esophageal-cancer
#10
Daisuke Muroya, Shigeru Yutani, Shigeki Shichijo, Akira Yamada, Shinjiro Sakamoto, Masayasu Naito, Koji Okuda, Michi Morita, Rin Yamaguchi, Kyogo Itoh
We retrospectively evaluated if personalized Kampo medicine (PKM) could facilitate CTL responses and clinical benefits induced by personalized peptide vaccination (PPV), in which HLA-matched vaccines were selected and administered based on the preexisting host immunity, for advanced esophageal cancer (aEC) patients. Among 34 aEC patients entered in the clinical study, 23 patients received PKM and PPV without (n = 12) or with chemotherapy (n = 11), while the remaining 11 patients did not receive PKM but received PPV without (n = 6) or with chemotherapy (n = 5), respectively...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27683115/cd8-foxp3-ratio-and-pd-l1-expression-associated-with-survival-in-pt3n0m0-stage-esophageal-squamous-cell-cancer
#11
Yingming Zhu, Minghuan Li, Dianbin Mu, Li Kong, Jianbo Zhang, Fen Zhao, Zhenxiang Li, Xuemei Liu, Cong Bo, Jinming Yu
Data describing relationships between the tumor immune microenvironment and patient outcome are limited for esophageal squamous cell cancer (ESCC). The present study investigated the prognostic values of programmed death-ligand 1 (PD-L1) expression and CD8+ or forkhead box protein 3+ (FOXP3+) tumor-infiltrating lymphocytes (TILs) in 133 pathological T3N0M0 stage ESCC patients who underwent radical resection without neoadjuvant or adjuvant therapy. CD8+ and FOXP3+ TIL densities as well as PD-L1 levels in tumor cells and lymphocytes, were assessed through immunohistochemical staining...
September 23, 2016: Oncotarget
https://www.readbyqxmd.com/read/27675652/circulating-lymphocyte-count-during-neoadjuvant-chemoradiation-therapy-for-esophageal-cancer-as-a-predictive-biomarker-of-pathologic-complete-response
#12
W Jiang, R Davuluri, P Fang, C Xu, J W Welsh, C H Crane, R U Komaki, J D Cox, C C Hsu, S H Lin
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27675071/immune-profile-to-lymphocyte-ratios-during-chemoradiation-are-predictors-of-clinical-outcomes-in-esophageal-cancer
#13
P Fang, W Jiang, R Davuluri, C Xu, J W Welsh, R U Komaki, C H Crane, C C Hsu, S H Lin
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27674056/influence-of-neutrophil-lymphocyte-ratio-and-other-independent-factors-predicting-failure-in-locally-advanced-esophageal-malignancies
#14
M M Mathew, N Elahi, A Osipov, D S Bitterman, W Talcott, R Tuli, K L Du, T O Thomas
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27673979/absolute-lymphocyte-count-nadir-during-chemoradiation-as-a-prognostic-indicator-of-esophageal-cancer-survival-outcomes
#15
R Davuluri, W Jiang, P Fang, C Xu, R U Komaki, C C Hsu, S H Lin, J W Welsh, J D Cox, C H Crane
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27650456/prognostic-value-of-preoperative-inflammatory-response-biomarkers-in-patients-with-esophageal-cancer-who-undergo-a-curative-thoracoscopic-esophagectomy
#16
Noriyuki Hirahara, Takeshi Matsubara, Yoko Mizota, Shuichi Ishibashi, Yoshitsugu Tajima
BACKGROUND: Several inflammatory response biomarkers, including lymphocyte-to-monocyte ratio (LMR), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) have been reported to predict survival in various cancers. The aim of this study is to evaluate the clinical value of these biomarkers in patients undergoing curative resection for esophageal cancer. METHODS: The LMR, NLR and PLR were calculated in 147 consecutive patients who underwent esophagectomy between January 2006 and February 2015...
September 20, 2016: BMC Surgery
https://www.readbyqxmd.com/read/27635640/lymphocytic-esophagitis-a-histologic-pattern-with-emerging-clinical-ramifications
#17
Mikhail Lisovsky, Maria Westerhoff, Xuchen Zhang
The clinical significance of lymphocytic esophagitis (LyE), which is characterized by the prominence of peripapillary intraepithelial lymphocytes (IELs) without significant granulocytosis, remains poorly understood. During the last few years, plausible clinical correlates and novel approaches for stratification of LyE have started to emerge. Association with Crohn's disease has been established in children, but is not observed in adults. In adults, the form of LyE showing CD4(+) -predominant IELs has been recently found to be associated with non-achalasia primary motility abnormalities...
September 16, 2016: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/27605525/the-role-of-microaspiration-in-the-pathogenesis-of-gastroesophageal-reflux-related-chronic-cough
#18
Pelin Özdemir, Münevver Erdinç, Rukiye Vardar, Ali Veral, Serdar Akyıldız, Özer Özdemir, Serhat Bor
Background/Aims: Gastroesophageal reflux disease (GERD) is one of the main causes of chronic cough. We evaluated the role of microaspiration in the pathogenesis of reflux-related cough by determining the amount of lipid-laden macrophages in bronchoalveolar lavage specimens. Methods: A total of 161 cases of chronic cough were evaluated, and 36 patients (average age 48.2 years) were recruited for this single center prospective study. Patients with a history of smoking, angiotensin converting enzyme inhibitor usage, any abnormality on pulmonary function tests, abnormal chest X-ray, occupational or environmental exposures, or upper airway cough syndrome were excluded...
September 8, 2016: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/27603913/cancer-testis-antigens-expression-regulation-tumor-invasion-and-use-in-immunotherapy-of-cancers
#19
Arash Salmaninejad, Mohammad Reza Zamani, Mehrnaz Pourvahedi, Zahra Golchehre, Ali Hosseini Bereshneh, Nima Rezaei
UNLABELLED: Cancer/testis antigens (CTAs) are named based on their expression pattern that is restricted in a number of normal and abnormal tissues. Tumor cells frequently express antigens whose expression is typically restricted to germ cells. Their unique expression pattern is guaranteed by precise epigenetic regulatory mechanisms. Because of their tumor-limited, high immunogenicity, and biased expression, discovery of these molecules provides unprecedented opportunities for further research and clinical development in the field of cancer diagnosis and immunotherapy...
October 2016: Immunological Investigations
https://www.readbyqxmd.com/read/27599460/the-pretreatment-controlling-nutritional-status-conut-score-is-an-independent-prognostic-factor-in-patients-with-resectable-thoracic-esophageal-squamous-cell-carcinoma-results-from-a-retrospective-study
#20
Takahiro Toyokawa, Naoshi Kubo, Tatsuro Tamura, Katsunobu Sakurai, Ryosuke Amano, Hiroaki Tanaka, Kazuya Muguruma, Masakazu Yashiro, Kosei Hirakawa, Masaichi Ohira
BACKGROUND: The purpose of this study was to investigate the impact of the Controlling Nutritional Status (CONUT) score on survival compared with the platelet to lymphocyte ratio (PLR), the neutrophil to lymphocyte ratio (NLR), and the Glasgow Prognostic Score (GPS) in patients with resectable thoracic esophageal squamous cell carcinoma (ESCC). METHODS: One hundred eighty-five consecutive patients who underwent subtotal esophagectomy with curative intent for resectable thoracic ESCC were retrospectively reviewed...
2016: BMC Cancer
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