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Lymphocytic esophagitis

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https://www.readbyqxmd.com/read/29760351/leptin-aggravates-reflux-esophagitis-by-increasing-tissue-levels-of-macrophage-migration-inhibitory-factor-in-rats
#1
Tsugihiro Murata, Kiyotaka Asanuma, Nobuyuki Ara, Katsunori Iijima, Waku Hatta, Shin Hamada, Naoki Asano, Tomoyuki Koike, Akira Imatani, Atsushi Masamune, Tooru Shimosegawa
Leptin, produced primarily by the adipose tissue, acts as a pro-inflammatory modulator, thereby contributing to the development of obesity-related disease. Although high levels of leptin in the obese are closely related to gastroesophageal reflux disease, the mechanism by which leptin influences esophageal inflammation remains unknown. Macrophage migration inhibitory factor (MIF) is produced by immune cells, such as T lymphocytes and macrophages, and MIF is known to induce the production of tumor necrosis factor α (TNF-α), interleukin 1β (IL-1β) and interleukin 6 (IL-6)...
2018: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29757356/developing-a-diagnostic-understanding-of-gerd-phenotypes-through-the-analysis-of-levels-of-mucosal-injury-immune-activation-and-psychological-comorbidity
#2
C Zhong, K Liu, K Wang, H Liu, H Su, J Wu, L Duan
Patients with gastroesophageal reflux disease (GERD) can present with typical or atypical symptoms. The aim of this study is to explore the underlying physiological and psychological mechanisms that lead to different symptomatic manifestations of GERD. A total of 238 patients diagnosed with GERD underwent gastroscopy, 24 h multichannel intraluminal impedance-pH (MII-pH) monitoring, and psychological assessment with questionnaires. Patient symptoms were used to classify GERD into phenotypes of typical reflux syndrome (TRS, n = 87), reflux chest pain syndrome (RCS, n = 98), and extraesophageal syndromes (EES, n = 53)...
May 10, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29738752/neutrophil-to-lymphocyte-ratio-as-predictor-of-treatment-response-in-esophageal-squamous-cell-cancer
#3
Arianna Barbetta, Tamar B Nobel, Smita Sihag, Meier Hsu, Kay See Tan, Manjit S Bains, James M Isbell, Yelena Y Janjigian, Abraham J Wu, Matthew J Bott, David R Jones, Daniela Molena
BACKGROUND: The aim of this study was to assess the variation of NLR (ΔNLR), before and after chemoradiotherapy, as a predictor of treatment response and a prognostic factor for recurrence and disease-free survival (DFS) in patients with esophageal squamous cell cancer (ESCC) treated with chemoradiotherapy with or without surgery. METHODS: Patients with locally advanced ESCC, treated with chemoradiation with and without surgery that had a complete blood count, before and after chemoradiotherapy, were included...
May 5, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29725336/tribody-her2-2-xcd16-is-more-effective-than-trastuzumab-in-enhancing-%C3%AE-%C3%AE-t-cell-and-natural-killer-cell-cytotoxicity-against-her2-expressing-cancer-cells
#4
Hans H Oberg, Christian Kellner, Daniel Gonnermann, Susanne Sebens, Dirk Bauerschlag, Martin Gramatzki, Dieter Kabelitz, Matthias Peipp, Daniela Wesch
An enhanced expression of human epidermal growth factor receptor 2 (HER2, ErbB2) often occurs in an advanced stage of breast, ovarian, gastric or esophageal cancer, and pancreatic ductal adenocarcinoma (PDAC). Commonly, HER2 expression is associated with poor clinical outcome or chemoresistance in ovarian and breast cancer patients. Treatment with humanized anti-HER2 monoclonal antibodies, such as trastuzumab or pertuzumab, has improved the outcome of patients with HER2-positive metastatic gastric or breast cancer, but not all patients benefit...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29707302/prognostic-and-clinicopathological-significance-of-platelet-to-lymphocyte-ratio-in-esophageal-cancer-a-meta-analysis
#5
Juhong Deng, Peng Zhang, Yue Sun, Ping Peng, Yu Huang
Background: The prognostic and clinicopathological significance of the platelet to lymphocyte ratio (PLR) has been studied in various cancers. However, studies examining the role of PLR in esophageal cancer have not yielded consistent results. The purpose of this meta-analysis was to study the prognostic and clinicopathological significance of PLR in esophageal cancer patients. Methods: We performed a literature search in three major databases: PubMed, Web of Science and Embase (up until May 1, 2017)...
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29683072/prognostic-value-of-platelet-to-lymphocyte-ratio-in-oncologic-outcomes-of-esophageal-cancer-a-systematic-review-and-meta-analysis
#6
Xiangwei Zhang, Yang Wang, Linping Zhao, Shaowei Sang, Lin Zhang
The platelet-to-lymphocyte ratio (PLR) is a useful prognostic factor in several cancers. However, the prognostic role of PLR in esophageal cancer remains controversial. The aim of this study is to evaluate the association between PLR and the oncologic outcome of esophageal cancer patients through a meta-analysis. Relevant articles were researched from Embase, PubMed, and Web of Science databases. The meta-analysis was performed using hazard ratio (HR) and 95% confidence intervals (CIs) as effect measures. Finally, 19 articles with 6134 patients were included in our study...
April 1, 2018: International Journal of Biological Markers
https://www.readbyqxmd.com/read/29608256/aging-related-prognosis-analysis-of-definitive-radiotherapy-for-very-elderly-esophageal-cancer
#7
Yong-Chun Zhou, Li-Li Chen, Hong-Bo Xu, Qian Sun, Qi Zhang, Han-Fei Cai, Hao Jiang
Because of the exclusion for the patients more than 75 years (very elderly patients) in many clinical trials of esophageal cancer (EC), there is no consensus on prognosis and treatment for this population. We aim to evaluate the outcomes and aging-related prognostic factors of definitive radiotherapy (RT) for very elderly EC patients. We retrospectively analyzed 149 very elderly EC patients consecutively treated between January 2015 and June 2016 by definitive intensity-modulated radiotherapy (IMRT) with or without chemotherapy...
April 2, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29601941/different-profile-of-cytokine-production-in-patients-with-systemic-sclerosis-and-association-with-clinical-manifestations
#8
Andréa Tavares Dantas, Anderson Rodrigues de Almeida, Maria Clara Pinheiro Duarte Sampaio, Marina Ferraz Cordeiro, Priscilla Stela Santana de Oliveira, Henrique de Ataíde Mariz, Michelly Cristiny Pereira, Moacyr Jesus Barreto de Melo Rego, Ivan da Rocha Pitta, Angela Luzia Branco Pinto Duarte, Maira Galdino da Rocha Pitta
Immune dysregulation is a central process in the pathogenesis of systemic sclerosis (SSc). Cytokines produced by lymphocytes and monocytes are important mediators and induce tissue damage, recruit additional inflammatory cells, and promote extracellular matrix production and fibrosis. In the present research, we aimed to study the associations between levels of cytokines in serum and culture supernatants from peripheral blood mononuclear cells (PBMCs) and clinical manifestations in SSc patients. Serum samples were obtained from 56 SSc patients and 56 unrelated age- and gender-matched healthy individuals...
March 27, 2018: Immunology Letters
https://www.readbyqxmd.com/read/29581759/the-value-of-preoperative-glasgow-prognostic-score-and-the-c-reactive-protein-to-albumin-ratio-as-prognostic-factors-for-long-term-survival-in-pathological-t1n0-esophageal-squamous-cell-carcinoma
#9
Xiangyang Yu, Yingsheng Wen, Yongbin Lin, Xuewen Zhang, Yongqiang Chen, Weidong Wang, Gongming Wang, Lanjun Zhang
Plenty of studies have confirmed the prognostic values of inflammation-based prognostic scores in many malignant tumors. In present study, we aim to explore whether these indexes has same prognostic values in patients with stage T1N0 esophageal squamous cell carcinoma (ESCC). The clinicopathological data of 160 consecutive patients with pathological stage T1N0 ESCC from January 2005 to December 2012 were collected retrospectively. As prognostic factors, the inflammation-based prognostic scores, including C-reactive protein (CRP), Glasgow prognostic score (GPS), prognostic index (PI), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and CRP to albumin ratio (CAR), were evaluated...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29563330/cd38-m-mdsc-expansion-characterizes-a-subset-of-advanced-colorectal-cancer-patients
#10
Tatiana A Karakasheva, George A Dominguez, Ayumi Hashimoto, Eric W Lin, Christopher Chiu, Kate Sasser, Jae W Lee, Gregory L Beatty, Dmitry I Gabrilovich, Anil K Rustgi
BACKGROUND: Myeloid-derived suppressor cells (MDSCs) are a population of immature immune cells with several protumorigenic functions. CD38 is a transmembrane receptor-ectoenzyme expressed by MDSCs in murine models of esophageal cancer. We hypothesized that CD38 could be expressed on MDSCs in human colorectal cancer (CRC), which might allow for a new perspective on therapeutic targeting of human MDSCs with anti-CD38 monoclonal antibodies in this cancer. METHODS: Blood samples were collected from 41 CRC patients and 8 healthy donors, followed by peripheral blood mononuclear cell (PBMC) separation...
March 22, 2018: JCI Insight
https://www.readbyqxmd.com/read/29552775/observation-of-clinical-efficacy-of-application-of-enhanced-recovery-after-surgery-in-perioperative-period-on-esophageal-carcinoma-patients
#11
Ziteng Zhang, Ling Zong, Baobin Xu, Ronghang Hu, Ming Ma, Haixiang Wei, Yanhong Meng
PURPOSE: To observe the clinical efficacy of the application of enhanced recovery after surgery (ERAS) in the perioperative period of esophageal carcinoma patients. METHODS: A total of 114 patients who were admitted to Affiliated Hospital of Jining Medical University for surgical treatment of esophageal carcinoma between June 2012 and June 2016 were enrolled and randomly divided into the intervention group and the regular group according to the difference of management procedures during the perioperative period...
January 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29552135/programmed-death-ligand-1-expression-in-esophageal-cancer-following-definitive-chemoradiotherapy-prognostic-significance-and-association-with-inflammatory-biomarkers
#12
Yating Tang, Guang Li, Shan Wu, Lingrong Tang, Ning Zhang, Jinzhao Liu, Shuo Zhang, Lei Yao
Immunotherapy with anti-programmed cell death protein 1 or programmed death ligand 1 (PD-L1) agents has demonstrated promising efficacy for the treatment of various types of malignancies. However, the role of PD-L1 as a tumor prognostic marker remains poorly understood. In the present study, the prognostic value of PD-L1 expression in esophageal carcinoma (EC) following definitive chemoradiotherapy (CRT) was investigated, and its associations with three systemic inflammation biomarkers, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and lymphocyte-to-monocyte ratio (LMR) were further explored...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29550999/evaluation-of-the-immunoreactivity-of-nerve-growth-factor-and-tropomyosin-receptor-kinase-a-in-the-esophagus-of-noninfected-and-infected-individuals-with-trypanosoma-cruzi
#13
Jacqueline Garcia Duarte, Rodolfo Duarte Nascimento, Patrícia Rocha Martins, Débora d'Ávila Reis
Megaesophagus is one of the major manifestations of the chronic phase of Chagas disease. Its primary symptom is generally dysphagia due to disturbance in the lower esophageal sphincter. Microscopically, the affected organ presents denervation, which has been considered as consequence of an inflammatory process that begins at the acute phase and persists in the chronic phase. Inflammatory infiltrates are composed of lymphocytes, macrophages, natural killer cells, mast cells, and eosinophils. In this study, we evaluated the immunoreactivity of nerve growth factor (NGF), and of its receptor tropomyosin receptor kinase A (TrkA), molecules that are well known for having a relevant role in neuroimmune communication in the gastrointestinal tract...
March 17, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29535059/associations-of-microscopic-colitis-with-other-lymphocytic-disorders-of-the-gastrointestinal-tract
#14
Amnon Sonnenberg, Kevin O Turner, Robert M Genta
BACKGROUND & AIMS: Lymphocytic disorders of the upper and lower gastrointestinal tract seem to cluster in patients. We aimed to assess the frequency of comorbid occurrence of lymphocytic disorders in patients with microscopic colitis (MC). METHODS: We collected data from the Miraca Life Sciences Database, a large national electronic repository of histopathologic records of patients throughout the United States. In a population of 228,506 patients who underwent bidirectional endoscopy from January 2008 through July 2016, we studied the comorbid occurrence of celiac disease, duodenal intraepithelial lymphocytosis, lymphocytic gastritis, and lymphocytic esophagitis among 3456 patients with MC...
March 11, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29530432/high-lymphocyte-count-during-neoadjuvant-chemoradiotherapy-is-associated-with-improved-pathologic-complete-response-in-esophageal-cancer
#15
Penny Fang, Wen Jiang, Rajayogesh Davuluri, Cai Xu, Sunil Krishnan, Radhe Mohan, Albert C Koong, Charles C Hsu, Steven H Lin
BACKGROUND AND PURPOSE: Neoadjuvant chemoradiation (nCRT) can reduce tumor infiltrating lymphocytes. We examined absolute lymphocyte count (ALC) nadir during nCRT for esophageal cancer (EC) and pathologic complete response (pCR). MATERIALS AND METHODS: Patients with stage I-IVA EC (n = 313) treated 2007-2013 with nCRT followed by surgery were analyzed. ALC was obtained before, during/weekly, and one month after CRT. pCR was defined as no viable tumor cells at surgery...
March 9, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29528703/prognostic-significance-of-the-prognostic-nutritional-index-in-patients-with-recurrent-esophageal-squamous-cell-carcinoma
#16
Mitsuhiro Nakatani, Kazuhiro Migita, Sohei Matsumoto, Kohei Wakatsuki, Masahiro Ito, Hiroshi Nakade, Tomohiro Kunishige, Mutsuko Kitano, Masayuki Sho
The aim of this study was to evaluate the prognostic impact of the prognostic nutritional index (PNI) in patients with recurrent esophageal squamous cell carcinoma (ESCC). We retrospectively reviewed 76 ESCC patients who developed recurrence after curative subtotal esophagectomy at Nara Medical University Hospital between January 2001 and October 2016. The PNI at ESCC recurrence was calculated as 10 × serum albumin (g/dl) + 0.005 × total lymphocyte count (/mm3 ). The cutoff value of the PNI was set at 45...
April 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29521534/the-prognostic-nutrition-index-predicts-the-development-of-hematological-toxicities-in-and-the-prognosis-of-esophageal-cancer-patients-treated-with-cisplatin-plus-5-fluorouracil-chemotherapy
#17
Yoshifumi Matsumoto, Qiliang Zhou, Kensuke Kamimura, Masato Moriyama, Yasuo Saijo
The prognostic nutrition index (PNI), calculated based on serum albumin and lymphocyte counts, predicts the prognosis of several cancers, including operated esophageal cancers. In this study, we determined whether PNI could predict the occurrence of severe adverse events by chemotherapy and chemoradiotherapy, and overall survival in esophageal cancer. We collected data from 191 patients with esophageal cancer treated with at least one course of cisplatin and 5-fluorouracil from 2005 to 2016. We compared the incidences of severe adverse events and overall survival between a high- and a low-PNI group...
April 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29515971/the-expression-and-prognostic-impact-of-immune-cytolytic-activity-related-markers-in-human-malignancies-a-comprehensive-meta-analysis
#18
Constantinos Roufas, Dimitrios Chasiotis, Anestis Makris, Christodoulos Efstathiades, Christos Dimopoulos, Apostolos Zaravinos
Background: Recently, immune-checkpoint blockade has shown striking clinical results in different cancer patients. However, a significant inter-individual and inter-tumor variability exists among different cancers. The expression of the toxins granzyme A (GZMA) and perforin 1 (PRF1), secreted by effector cytotoxic T cells and natural killer (NK) cells, were recently used as a denominator of the intratumoral immune cytolytic activity (CYT). These levels are significantly elevated upon CD8+ T-cell activation as well as during a productive clinical response against immune-checkpoint blockade therapies...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29487719/prognostic-role-of-tumor-infiltrating-cd57-positive-lymphocytes-in-solid-tumors-a-meta-analysis
#19
Guoming Hu, Shimin Wang
The prognostic role of tumor-infiltrating CD57-positive lymphocytes (CD57+ lymphocytes) in human solid tumors remains controversial. Herein, we conducted a meta-analysis including 26 published studies with 7656 patients identified from PubMed and EBSCO to assess the prognostic impact of tumor-infiltrating CD57+ lymphocytes in human solid tumors. We found that CD57+ lymphocyte infiltration significantly improved overall survival (OS) including 1 - year, 3 - year and 5 - year survival, and disease - free survival (DFS) in all types of solid tumors...
January 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29435305/clinical-significance-of-the-c-reactive-protein-to-albumin-ratio-for-the-prognosis-of-patients-with-esophageal-squamous-cell-carcinoma
#20
Masaki Kunizaki, Tetsuro Tominaga, Kouki Wakata, Takuro Miyazaki, Keitaro Matsumoto, Yorihisa Sumida, Shigekazu Hidaka, Takuya Yamasaki, Toru Yasutake, Terumitu Sawai, Ryuji Hamamoto, Atsushi Nanashima, Takeshi Nagayasu
The aim of the present study was to investigate the prognostic value of the C-reactive protein-to-albumin ratio (CAR) and compare it with other inflammation-based prognostic scores (Glasgow prognostic score, modified Glasgow prognostic score, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, prognostic nutritional index and prognostic index) in patients with esophageal squamous cell cancer (ESCC). A database of 116 patients with primary ESCC who underwent treatment at the Division of Surgical Oncology at Nagasaki University Hospital between January 2007 and August 2014 was retrospectively reviewed and the correlations between CAR and overall survival (OS) were investigated...
February 2018: Molecular and Clinical Oncology
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