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Lymphocytic esophagitis

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https://www.readbyqxmd.com/read/28892265/effects-of-preemptive-analgesia-with-flurbiprofen-ester-on-lymphocytes-and-natural-killer-cells-in-patients-undergoing-esophagectomy-a-randomized-controlled-pilot-study
#1
Yi Zhou, Jinxi Huang, Yu Bai, Changsheng Li, Xihua Lu
BACKGROUND: Tumors may induce systemic immune dysfunction, which can be aggravated by surgery and anesthesia/analgesia. Data on the effect of flurbiprofen preemptive analgesia on immune dysfunction is limited. The aim of this study was to investigate the effect of flurbiprofen preemptive analgesia on lymphocytes and natural killer (NK) cells in patients undergoing thoracotomy and thoracoscopy radical esophagectomy, and to explore the analgesic methods suitable for tumor patients. METHODS: This was a randomized controlled pilot study of 89 patients with esophageal cancer treated with surgery at the Henan Cancer Hospital between January 1, 2015 and December 31, 2016...
September 11, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28883282/development-of-immune-checkpoint-inhibitors
#2
Shigehisa Kitano
Immune checkpoint inhibitors are the most striking innovation in the clinical development of immunotherapy. Monoclonal antibodies (mAbs) restore and augment the antitumor immune activities of cytotoxic T cells by mainly blocking immune checkpoint molecules on T cells or their ligands on antigen-presenting and tumor cells. Based on preclinical data, many clinical trials have demonstrated the acceptable safety profiles and efficacies of mAb in various cancers. The A first-in-class approved immune checkpoint inhibitor is ipilimumab, which is a fully humanized mAb that blocks the immunosuppressive signal by cytotoxic T-lymphocyte antigen 4...
2017: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/28871164/tumor-infiltrating-cd45ro-memory-t-lymphocytes-predict-favorable-clinical-outcome-in-solid-tumors
#3
Guoming Hu, Shimin Wang
The prognostic role of tumor-infiltrating CD45RO(+) memory T lymphocytes (CD45RO(+) T cells) in human solid tumors remains controversial. Herein, we conducted a meta-analysis including 25 published studies with 4720 patients identified from PubMed and EBSCO to assess the prognostic impact of tumor-infiltrating CD45RO(+) T cells in human solid tumors. We found that CD45RO(+) T cell infiltration was significantly associated with improved overall survival (OS) and disease-free survival (DFS) in all types of solid tumors...
September 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28816138/lymphocyte-nadir-and-esophageal-cancer-survival-outcomes-after-chemoradiation-therapy
#4
Rajayogesh Davuluri, Wen Jiang, Penny Fang, Cai Xu, Ritsuko Komaki, Daniel R Gomez, James Welsh, James D Cox, Christopher H Crane, Charles C Hsu, Steven H Lin
PURPOSE: Host immunity may affect the outcome in patients with esophageal cancer. We sought to identify factors that influenced absolute lymphocyte count (ALC) nadir during chemoradiation therapy (CRT) for esophageal cancer (EC) and looked for clinically relevant associations with survival. METHODS AND MATERIALS: 504 patients with stage I-III EC (2007-2013) treated with neoadjuvant or definitive CRT with weekly ALC determinations made during treatment were analyzed...
September 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28814297/genotyping-and-comparative-pathology-of-spirocerca-in-black-backed-jackals-canis-mesomelas-in-south-africa
#5
M M Bumby, M C Williams, J C A Steyl, R Harrison-White, H Lutermann, G T Fosgate, P J de Waal, J Mitha, S J Clift
BACKGROUND: The pathology of spirocercosis, a disease caused by the infestation of carnivores with the nematode Spirocerca lupi, has been extensively described in domestic dogs and coyotes. However, it has not been described in wild carnivores in South Africa. The aim of this study was to evaluate whether black-backed jackals are a host for Spirocerca species and to provide a detailed description of the associated pathology. Jackals were also stratified according to age and the Spirocerca species recovered were characterized using molecular techniques...
August 16, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28806299/the-dynamic-and-transient-immune-microenvironment-in-locally-advanced-esophageal-adenocarcinoma-post-chemoradiation
#6
Ronan J Kelly, Ali H Zaidi, Matthew A Smith, Ashten N Omstead, Juliann E Kosovec, Daisuke Matsui, Samantha A Martin, Christina DiCarlo, E Day Werts, Jan F Silverman, David H Wang, Blair A Jobe
OBJECTIVE: The aim of this study was to assess the impact of chemoradiation on the immune microenvironment to influence and optimally design future neoadjuvant clinical trials. SUMMARY BACKGROUND DATA: Programmed death (PD)-1 inhibitors in metastatic gastroesophageal cancer have demonstrated response rates of approximately 25% in programmed death ligand-1 (PD-L1+) tumors. Unfortunately, the majority of patients do not respond. Therefore, a rationale strategy of combining immunotherapeutic agents with chemoradiation in earlier stage esophageal cancer may prevent metastatic disease in patients...
August 10, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28799624/neutrophil-to-lymphocyte-ratio-as-prognostic-indicator-for-patients-with-esophageal-squamous-cell-cancer
#7
Guo-Dong Gao, Bo Sun, Xian-Bin Wang, Shi-Meng Wang
BACKGROUND: This study aimed to evaluate the correlation between neutrophil to lymphocyte ratio (NLR) with overall survival (OS) of esophageal squamous cell carcinoma (ESCC) patients. METHOD: Records of patients with diagnosed ESCC were reviewed. Leukocyte counts and patients' characteristics were extracted from their clinical records to calculate NLR. Correlation between NLR and baseline characteristics with overall survival (OS) was then analyzed using Cox regression...
August 7, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28789612/lichenoid-esophagitis-presenting-as-fatal-upper-gastrointestinal-bleeding-in-a-52%C3%A2-year-old-woman-a-case-diagnosed-by-autopsy
#8
Andrew Mitchell, Tony Petrella
BACKGROUND: "Lichenoid esophagitis" is a descriptive term for a lichenoid pattern of inflammation in the esophagus for which a precise histologic diagnosis cannot be established. The differential diagnosis includes lichen planus, a drug-related reaction, and viral infection. Lichenoid esophagitis causing death has not been reported previously. We describe a case, diagnosed by autopsy, of lichenoid esophagitis in which massive bleeding from generalized epithelial sloughing and a large longitudinal ulcer proved fatal...
August 8, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28767405/the-integrative-clinical-impact-of-tumor-infiltrating-t-lymphocytes-and-nk-cells-in-relation-to-b-lymphocyte-and-plasma-cell-density-in-esophageal-and-gastric-adenocarcinoma
#9
Maria C Svensson, Carl Fredrik Warfvinge, Richard Fristedt, Charlotta Hedner, David Borg, Jakob Eberhard, Patrick Micke, Björn Nodin, Karin Leandersson, Karin Jirström
BACKGROUND: Several studies have demonstrated a prognostic impact of tumor-infiltrating T lymphocytes and natural killer (NK) cells in esophageal and gastric adenocarcinoma, but whether these associations differ by the density of tumor-infiltrating immune cells of the B cell lineage remains largely unknown. RESULTS: High infiltration of any T and NK lymphocytes investigated was in general associated with a favorable prognosis, but the strongest beneficial prognostic impact was seen in combination with high B lymphocyte infiltration...
July 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28704189/chronic-hepatitis-due-to-gluten-enteropathy-a-case-report
#10
Irina I Ivanova, Denitsa Y Dukova, Pavlina G Boikova, Lili S Grudeva, Ivan B Shalev, Iskren A Kotzev
BACKGROUND: Celiac disease is an immune-mediated enteropathy precipitated by exposure to dietary gluten in genetically predisposed individuals. CASE DESCRIPTION: A 45-year-old Caucasian woman presented with severe iron-deficient anemia and mild elevation of liver enzymes. Upper endoscopy was done in the context of evaluation of anemia, which revealed reduced duodenal folds and mosaic pattern of the mucosa, but also grade II esophageal varices and portal hypertensive gastropathy...
June 1, 2017: Folia Medica
https://www.readbyqxmd.com/read/28685065/increased-neutrophil-to-lymphocyte-ratio-is-a-novel-marker-for-nutrition-inflammation-and-chemotherapy-outcome-in-patients-with-locally-advanced-and-metastatic-esophageal-squamous-cell-carcinoma
#11
Yu Sato, Kenji Gonda, Maiko Harada, Yuki Tanisaka, Shin Arai, Yumi Mashimo, Hirotoshi Iwano, Hiroshi Sato, Shomei Ryozawa, Takao Takahashi, Shinichi Sakuramoto, Masahiko Shibata
Esophageal squamous cell carcinoma (ESCC) is one of the most common types of cancer, and its progression is strongly influenced by the presence of inflammation. Recently, there has been growing interest in the host inflammatory response, and increasing evidence has indicated that the neutrophil-to-lymphocyte ratio (NLR), a useful marker of systemic inflammation, may be an effective prognostic indicator in various types of malignant diseases. In the present study, 260 patients with ESCC were enrolled, including 110 who received chemoradiation therapy (CRT) involving irradiation and chemotherapy of 5-fluorouracil and cisplatin, and 150 received chemotherapy using 5-fluorouracil and cisplatin (FP)...
July 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28679983/a-case-of-cytomegalovirus-infection-with-splenic-infarction-and-an-esophageal-ulcer-in-an-immunocompetent-adult
#12
Yoshiaki Shimizu, Takuya Komura, Takuya Seike, Ryotaro Nakai, Hitoshi Omura, Takashi Kagaya, Hajime Ohta, Satomi Kasashima, Atsuhiro Kawashima, Masashi Unoura
BACKGROUND: Recently, morbidities due to primary cytomegalovirus (CMV) infection have increased in young Japanese adults because of decreased anti-CMV antibodies in them. CMV infections are typically resolved naturally in immunocompetent individuals, and complications rarely occur. Here we present the case of an immunocompetent adult with CMV infection complicated by splenic infarctions and an esophageal ulcer. CASE REPORT: A 37-year-old male complaining of a prolonged fever and liver injury was admitted to hospital for a closed examination...
2017: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/28657901/increased-intraepithelial-cd3-t-lymphocytes-and-high-pd-l1-expression-on-tumor-cells-are-associated-with-a-favorable-prognosis-in-esophageal-squamous-cell-carcinoma-and-allow-prognostic-immunogenic-subgrouping
#13
Moritz Jesinghaus, Katja Steiger, Julia Slotta-Huspenina, Enken Drecoll, Nicole Pfarr, Petra Meyer, Björn Konukiewitz, Marcus Bettstetter, Kathrin Wieczorek, Katja Ott, Markus Feith, Rupert Langer, Wilko Weichert, Katja Specht, Melanie Boxberg
Esophageal squamous cell carcinoma (ESCC) is the most common esophageal cancer associated with poor prognosis and additional therapeutic strategies must be implemented to optimize ESCC treatment. Meanwhile, the important biologic role and potential prognostic and therapeutic implications of a tumors immunologic microenvironment (IM) have been recognized in various cancers.In order to investigate the contexture and the prognostic relevance of the IM in ESCC, we immunohistochemically evaluated the extent of overall/intraepithelial TILs (CD3+/CD8+) and of PD-1 / PD-L1 expression in a cohort of 125 therapy-naive ESCCs, additionally assessing PD-L1 copy number status via fluorescence in-situ hybridization...
July 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28644352/elevated-serum-tissue-transglutaminase-antibodies-in-children-with-eosinophilic-esophagitis
#14
Anna K Le Fevre, Marjorie M Walker, Amir Hadjiashrafy, Rani Bhatia, Joerg Mattes, Nicholas J Talley, Scott Nightingale
OBJECTIVES: This study compared the clinical and histopathological characteristics of children with eosinophilic esophagitis (EoE) and elevated anti-transglutaminase (TTG Ab) with those with EoE and normal TTG Ab titres. METHODS: Single-center chart and blinded histopathological review of patients diagnosed with EoE for a 4-year period, who had esophageal and duodenal biopsies taken at time of endoscopy, and TTG Ab measured within 6 months of biopsy. Patients with histology-proven CD were excluded...
July 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28601935/a-novel-systemic-immune-inflammation-index-predicts-survival-and-quality-of-life-of-patients-after-curative-resection-for-esophageal-squamous-cell-carcinoma
#15
Lu Wang, Cong Wang, Jiangfeng Wang, Xiaochen Huang, Yufeng Cheng
PURPOSE: A novel systemic immune-inflammation index (SII) based on platelet (P), neutrophil (N), and lymphocyte (L) counts has been reported to be associated with clinical outcomes in several solid tumors. We aimed to investigate its prognostic value in esophageal squamous cell carcinoma (ESCC) and the potential relationship with quality of life (QOL). METHODS: A total of 280 ESCC patients who underwent esophagectomy were enrolled. SII (SII = P × N/L) was calculated on the basis of data obtained within 1 week before surgery...
June 10, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28597685/a-gain-of-function-mutation-of-stat1-a-novel-genetic-factor-contributing-to-chronic-mucocutaneous-candidiasis
#16
Narges Eslami, Marzieh Tavakol, Mehrnaz Mesdaghi, Mohammad Gharegozlou, Jean-Laurent Casanova, Anne Puel, Satoshi Okada, Saba Arshi, Mohammad Hassan Bemanian, Morteza Fallahpour, Rasool Molatefi, Farhad Seif, Samaneh Zoghi, Nima Rezaei, Mohammad Nabavi
Heterozygous gain-of-function (GOF) mutations in the signal transducer and activator of transcription 1 (STAT1) have increasingly been identified as a genetic cause of autosomal-dominant (AD) chronic mucocutaneous candidiasis (CMC). In this article, we describe a 33-year-old man who experienced chronic refractory candidiasis, recurrent otitis media, and pneumonia resulting in bronchiectasis, severe oral and esophageal candidiases with strictures associated with hypothyroidism and immune hemolytic anemia. His son also suffered from persistent candidiasis, chronic diarrhea, poor weight gain, and pneumonia that resulted in his demise because of sepsis...
June 1, 2017: Acta Microbiologica et Immunologica Hungarica
https://www.readbyqxmd.com/read/28588575/gut-associated-lymphoid-tissue-a-key-tissue-inside-the-mucosal-immune-system-of-hens-immunized-with-escherichia-coli-f4
#17
Maria F Peralta, Alejandra Magnoli, Fabrisio Alustiza, Armando Nilson, Raúl Miazzo, Adriana Vivas
Immunoglobulin Y (IgY) is the predominant antibody found in hen's (Gallus domesticus) egg yolk. This antibody, developed against several microorganisms in hen egg yolk, has been successfully used as an alternative to immunoglobulins from mammals for use in immunodiagnostics and immunotherapy. Enteropathogenic Escherichia coli (E.coli) F4 is the main etiological agent associated with swine neonatal diarrhea, and it causes notable economic losses in swine production. The aim of the present study was to evaluate the relationship between humoral immune response and the activation of gut-associated lymphoid tissue (GALT) in laying hens intramuscularly immunized with E...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28586986/prognostic-significance-of-and-the-relationship-between-tumor-infiltrating-and-circulating-lymphocytes-to-macrophage-monocyte-ratio-in-patients-with-esophageal-squamous-cell-cancer-of-pathological-stage-t3n0m0
#18
Y Zhu, M Li, C Bo, X Liu, J Zhang, Z Li, F Zhao, L Kong, J Yu
No abstract text is available yet for this article.
May 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28575242/prognostic-significance-of-the-prognostic-nutritional-index-in-esophageal-cancer-patients-undergoing-neoadjuvant-chemotherapy
#19
M Nakatani, K Migita, S Matsumoto, K Wakatsuki, M Ito, H Nakade, T Kunishige, M Kitano, H Kanehiro
Nutritional status is one of the most important issues faced by cancer patients. Several studies have shown that a low preoperative nutritional status is associated with a worse prognosis in patients with various types of cancer, including esophageal cancer (EC). Recently, neoadjuvant chemotherapy (NAC) and/or radiotherapy have been accepted as the standard treatment for resectable advanced EC. However, NAC has the potential to deteriorate the nutritional status of a patient. This study aimed to evaluate the prognostic significance of the nutritional status for EC patients who underwent NAC...
August 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28573181/rings-in-the-esophagus-are-not-always-eosinophilic-esophagitis-case-series-of-ring-forming-lymphocytic-esophagitis-and-review-of-the-literature
#20
Julia L Pleet, Sofia Taboada, Arvind Rishi, Perry J Milman, Arvind J Trindade
Background and study aims  Lymphocytic esophagitis (LyE) is a form of chronic esophagitis characterized by edema and lymphocytic infiltration of the epithelial peripapillary fields, without eosinophils. Its significance is unclear, as it was previously thought to have little clinical impact. More recent literature, however, describes a paradigm shift suggesting a distinct entity. We report on 3 patients with dysphagia who were found to have esophageal rings on endoscopy. Histology was consistent with LyE...
June 2017: Endoscopy International Open
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