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Lymphocytic esophagitis

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https://www.readbyqxmd.com/read/28453022/-evolution-of-epidemiological-and-clinical-characteristics-of-adults-patients-belonging-to-the-national-program-at-start-of-antiretroviral-therapy-in-the-chilean-aids-cohort-2001-2015
#1
Carlos Beltrán, Pedro Zitko, Marcelo Wolff, Fernando Bernal, Alicia Asenjo, Ana M Fernández, Ana Miles, Elizabeth Barthel, Gonzalo Wilson
BACKGROUND: Chilean AIDS Cohort is the oldest and extensive in Latin America and one of most numerous and with longer follow up time to international level. Records information from 14,873 patients out of approximately 22,000 in antiretroviral therapy in the public system and its results have allowed to know the national reality and have contributed to the adoption of public policies. AIM: To describe the demographic, clinical and immunological characteristics of patients who have started ART in Chile and its evolution over the past 15 years...
October 2016: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28451845/reflux-esophagitis-and-its-role-in-the-pathogenesis-of-barrett-s-metaplasia
#2
REVIEW
Rhonda Frances Souza
Reflux esophagitis damages the squamous epithelium that normally lines the esophagus, and promotes replacement of the damaged squamous lining by the intestinal metaplasia of Barrett's esophagus, the precursor of esophageal adenocarcinoma. Therefore, to prevent the development of Barrett's metaplasia and esophageal adenocarcinoma, the pathogenesis of reflux esophagitis must be understood. We have reported that reflux esophagitis, both in a rat model and in humans, develops as a cytokine-mediated inflammatory injury (i...
April 27, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28449147/french-comment-on-article-evaluation-of-narrow-band-imaging-signs-in-eosinophilic-and-lymphocytic-esophagitis
#3
(no author information available yet)
No abstract text is available yet for this article.
May 2017: Endoscopy
https://www.readbyqxmd.com/read/28429201/how-to-approach-lymphocytic-esophagitis
#4
REVIEW
Anh D Nguyen, Kerry B Dunbar
PURPOSE OF REVIEW: Lymphocytic esophagitis (LE) is an unusual esophageal condition defined by an increased number of lymphocytes in the esophageal epithelium. With few published studies of LE available, it is unclear whether LE is a truly distinct clinical entity or a histological manifestation of other known gastrointestinal disorders. This review summarizes recent studies of lymphocytic esophagitis. RECENT FINDINGS: Studies have suggested that LE may be related to eosinophilic esophagitis (EoE) or a manifestation of gastroesophageal reflux disease (GERD)...
June 2017: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/28429196/expression-of-programmed-cell-death-protein-1-by-tumor-infiltrating-lymphocytes-and-tumor-cells-is-associated-with-advanced-tumor-stage-in-patients-with-esophageal-adenocarcinoma
#5
Dagmar Kollmann, Desislava Ignatova, Julia Jedamzik, Yun-Tsan Chang, Gerd Jomrich, Matthias Paireder, Ivan Kristo, Dmitry Kazakov, Michal Michal, Antonio Cozzio, Wolfram Hoetzenecker, Tobias Schatton, Reza Asari, Matthias Preusser, Emmanuella Guenova, Sebastian F Schoppmann
BACKGROUND: Despite recent advances in the therapy for adenocarcinoma of the esophagogastric junction (AEG), overall prognosis remains poor. Programmed cell death protein 1 (PD1) is a co-inhibitory receptor primarily expressed by T-cells. Tumor cells can escape anticancer immune responses by triggering the PD1 pathway. Moreover, PD1 receptor engagement on cancer cells may trigger tumor-intrinsic growth signals. This study aimed to evaluate the potential clinical relevance of PD1 expression by tumor-infiltrating lymphocytes (TILs) and cancer cells in the AEG...
April 20, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28408841/cytokine-induced-killer-cells-dendritic-cells-and-cytokine-induced-killer-cells-immunotherapy-for-the-treatment-of-esophageal-cancer-in-china-a-meta-analysis
#6
Yan Liu, Ying Mu, Anqi Zhang, Shaoda Ren, Weihua Wang, Jiaping Xie, Yingxin Zhang, Changhui Zhou
BACKGROUND: Immunotherapy based on cytokine-induced killer cells or combination of dendritic cells and cytokine-induced killer cells (CIK/DC-CIK) showed promising clinical outcomes for treating esophageal cancer (EC). However, the clinical benefit varies among previous studies. Therefore, it is necessary to systematically evaluate the curative efficacy and safety of CIK/DC-CIK immunotherapy as an adjuvant therapy for conventional therapeutic strategies in the treatment of EC. MATERIALS AND METHODS: Clinical trials published before October 2016 and reporting CIK/DC-CIK immunotherapy treatment responses or safety for EC were searched in Cochrane Library, EMBASE, PubMed, Wanfang and China National Knowledge Internet databases...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28361224/immunotherapy-for-esophageal-squamous-cell-carcinoma
#7
REVIEW
Takashi Kojima, Toshihiko Doi
Esophageal squamous cell carcinoma have been frustrating to treat, with slow progress made on extending survival. Immunotherapy targeting immune checkpoints, T cells, and infiltrating lymphocytes has shown promise in early studies. The efficacy of pembrolizumab and nivolumab is encouraging. Anti-chemokine receptors and oncolytic viruses are also making headway against these stubborn tumors; improved results when immune checkpoint inhibitors are combined with radiation therapy are eagerly anticipated. Adoptive T cell therapy and vaccines are also under development...
May 2017: Current Oncology Reports
https://www.readbyqxmd.com/read/28359471/targeting-immune-checkpoints-in-esophageal-cancer-a-high-mutational-load%C3%A2-tumor
#8
REVIEW
Rajeev Dhupar, Lauren Van Der Kraak, Arjun Pennathur, Matthew J Schuchert, Katie S Nason, James D Luketich, Michael T Lotze
Checkpoint inhibitors (eg, programmed cell death protein 1 [PD-1], programmed cell death ligand 1 [PD-L1], cytotoxic T-lymphocyte associated protein 4 [CTLA-4] antibodies) are changing how we understand cancer and provide a means to develop modern immunotherapies. An emergent notion relates success with checkpoint inhibitors with high mutational load tumors. There are few studies that examine checkpoint protein expression and relate these to clinical outcomes after the conventional treatment of patients with esophageal cancer, which has a high mutational load...
April 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28322245/tumour-infiltrating-lymphocytes-correlate-with-improved-survival-in-patients-with-esophageal-squamous-cell-carcinoma
#9
Dongxian Jiang, Yalan Liu, Hao Wang, Haixing Wang, Qi Song, Akesu Sujie, Jie Huang, Yifan Xu, Haiying Zeng, Lijie Tan, Yingyong Hou, Chen Xu
We undertook a study of tumour infiltrating lymphocytes (TILs) in a large and relatively homogeneous group of patients with completely resected esophageal squamous cell carcinoma (ESCC). Hematoxylin and eosin-stained sections of 235 ESCC tumours were evaluated for density of TILs in intratumoural (iTIL) and stromal compartments (sTIL). Foxp3+, CD4+, and CD8+ T cells in tumoural and stromal areas were evaluated by immunohistochemistry. Of the 235 tumours, high sTIL (>10%), and iTIL (>10%) were observed in 101 (43...
March 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28294486/pd-l1-expression-at-tumor-invasive-front-is-associated-with-emt-and-poor-prognosis-in-esophageal-squamous-cell-carcinoma
#10
Satoshi Tsutsumi, Hiroshi Saeki, Yuichiro Nakashima, Shuhei Ito, Eiji Oki, Masaru Morita, Yoshinao Oda, Shinji Okano, Yoshihiko Maehara
Programmed death-ligand 1 (PD-L1) plays a crucial role in the host immune system in cancer progression. The gene promoter region of PD-L1 also contains a binding site for ZEB1, a transcription factor related to epithelial-mesenchymal transition (EMT). The purpose of this study was to clarify the relationship between PD-L1 and EMT and its clinical importance in esophageal squamous cell carcinoma (ESCC). PD-L1 and ZEB1 expression at the tumor invasive front was examined by immunohistochemistry in resected specimens from 90 patients with ESCC who underwent surgery without preoperative therapy, and their expression and clinicopathological factors were compared...
March 14, 2017: Cancer Science
https://www.readbyqxmd.com/read/28289861/expression-patterns-of-programmed-death-ligand-1-in-esophageal-adenocarcinomas-comparison-between-primary-tumors-and-metastases
#11
Bastian Dislich, Alexandra Stein, Christian A Seiler, Dino Kröll, Sabina Berezowska, Inti Zlobec, José Galvan, Julia Slotta-Huspenina, Axel Walch, Rupert Langer
Expression analysis of programmed death-ligand 1 (PD-L1) may be helpful in guiding clinical decisions for immune checkpoint inhibition therapy, but testing by immunohistochemistry may be hampered by heterogeneous staining patterns within tumors and expression changes during metastatic course. PD-L1 expression (clone SP142) was investigated in esophageal adenocarcinomas using tissue microarrays (TMA) from 112 primary resected tumors, preoperative biopsies and full slide sections from a subset of these cases (n = 24), corresponding lymph node (n = 55) and distant metastases (n = 17)...
March 13, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/28268208/the-value-of-the-combination-of-hemoglobin-albumin-lymphocyte-and-platelet-in-predicting-platinum-based-chemoradiotherapy-response-in-male-patients-with-esophageal-squamous-cell-carcinoma
#12
Lihong Cong, Likuan Hu
OBJECTIVE: The predictive value of HALP in esophageal cancer is currently unclear. We aimed to evaluate the value of HALP in predicting platinum-based definitive chemoradiotherapy response in male patients with esophageal squamous cell carcinoma. METHODS: Data from all newly diagnosed patients with esophageal squamous cell carcinoma (ESCC) were collected from January 1, 2010 to December 31, 2014 in Qilu Hospital. The treatment protocol was definitive chemoradiotherapy consisting of docetaxel plus cisplatin or carboplatin...
March 4, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28260931/prognostic-and-clinicopathologic-significance-of-neutrophil-to-lymphocyte-ratio-in-esophageal-squamous-cell-carcinoma-evidence-from-a-meta-analysis
#13
Yu Huang, Yue Sun, Ping Peng, Sixian Zhu, Wei Sun, Peng Zhang
PURPOSE: Evidence from an increasing number of studies has demonstrated that the neutrophil-to-lymphocyte ratio (NLR) is a prognostic factor for various cancers. However, it is unclear whether NLR predicts prognosis in esophageal squamous cell carcinoma (ESCC). We conducted a meta-analysis to investigate the prognostic and clinicopathologic significance of NLR in patients with ESCC. PATIENTS AND METHODS: Selected studies were identified by searches in PubMed, Embase, and Web of Science databases and filtered using our prepared criteria...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28246468/lymphocytic-esophagitis-still-an-enigma-a-decade-later
#14
REVIEW
Carol Rouphael, Ilyssa O Gordon, Prashanthi N Thota
Lymphocytic esophagitis (LE) is a clinicopathologic entity first described by Rubio et al in 2006. It is defined as peripapillary intraepithelial lymphocytosis with spongiosis and few or no granulocytes on esophageal biopsy. This definition is not widely accepted and the number of lymphocytes needed to make the diagnosis varied in different studies. Multiple studies have described potential clinical associations and risk factors for LE, such as old age, female gender and smoking history. This entity was reported in inflammatory bowel disease in the pediatric population but not in adults...
February 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28243122/the-lymphocyte-monocyte-ratio-predicts-tumor-response-and-survival-in-patients-with-locally-advanced-esophageal-cancer-who-received-definitive-chemoradiotherapy
#15
Xuemei Liu, Minghuan Li, Fen Zhao, Yingming Zhu, Yijun Luo, Li Kong, Hui Zhu, Yan Zhang, Fang Shi, Jinming Yu
BACKGROUND: The lymphocyte-monocyte ratio (LMR), a simple biomarker that can reflect the antitumor immune response of the host, has been associated with patient prognosis in several solid tumors. The aim of this study was to evaluate whether LMR can predict clinical tumor response and prognosis in patients with locally advanced esophageal squamous cell carcinoma (ESCC) who received definitive chemoradiotherapy (CRT). PATIENTS AND METHODS: A total of 162 advanced ESCC patients treated at our institution between January 2012 and December 2013 were retrospectively recruited for analysis...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28201841/evaluation-of-narrow-band-imaging-signs-in-eosinophilic-and-lymphocytic-esophagitis
#16
Tamaki Ichiya, Kyosuke Tanaka, Carlos A Rubio, Ulf Hammar, Peter T Schmidt
Background and study aims No specific endoscopic signs for diagnosing eosinophilic esophagitis (EoE) have been described and very few studies have reported endoscopic signs for lymphocytic esophagitis (LyE). This study aimed to assess the utility of narrow-band imaging magnifying endoscopy (NBI-ME) in predicting EoE/LyE diagnosis before histopathological assessment. Patients and methods Adult patients with dysphagia and/or food impaction who underwent esophagogastroduodenoscopy followed by NBI-ME and biopsies were included...
May 2017: Endoscopy
https://www.readbyqxmd.com/read/28195186/neutrophil-to-lymphocyte-ratio-as-a-prognostic-biomarker-for-patients-with-locally-advanced-esophageal-squamous-cell-carcinoma-treated-with-definitive-chemoradiotherapy
#17
Xi-Lei Zhou, Yong-Qiang Li, Wei-Guo Zhu, Chang-Hua Yu, Ya-Qi Song, Wan-Wei Wang, Dong-Cheng He, Guang-Zhou Tao, Yu-Suo Tong
The present study evaluated the clinical and prognostic value of neutrophil-to-lymphocyte ratio (NLR) in patients with locally advanced esophageal squamous cell carcinoma (ESCC) treated with definitive chemoradiotherapy (dCRT). A total of 517 patients with ESCC were enrolled and analysed retrospectively. The NLR was calculated at three time points: baseline, post-treatment, and at the time of tumor progression. Elevated NLR was defined as a ratio ≥5. High NLR at baseline was present in 204 (39%) patients and was significantly correlated with larger tumour size, advanced TNM stage, worse ECOG performance status, and dCRT response (p < 0...
February 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28191357/metastatic-invasive-lobular-breast-cancer-presenting-clinically-with-esophageal-dysphagia
#18
Lilit Karapetyan, Heather Laird-Fick, Reuben Cuison
Background. Intra-abdominal metastases of invasive lobular breast cancer (ILBC) may be insidious. We report a case of metastatic ILBC that presented with dysphagia within weeks of a negative mammogram and before the development of intra-abdominal symptoms. Case. A 70-year-old female developed esophageal dysphagia. She underwent EGD which showed a short segment of stricture of the distal esophagus without significant mucosal changes. Biopsy was unremarkable and patient underwent lower esophageal sphincter (LES) dilation...
2017: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/28160141/clinical-impact-of-tumor-infiltrating-lymphocytes-in-esophageal-squamous-cell-carcinoma
#19
Tomoya Sudo, Ryosuke Nishida, Akihiko Kawahara, Kouhei Saisho, Koshi Mimori, Akira Yamada, Atsuhi Mizoguchi, Kazutaka Kadoya, Satoru Matono, Naoki Mori, Toshiaki Tanaka, Yoshito Akagi
BACKGROUND: Recently, several immune checkpoint inhibitors have been developed and are being used to treat malignant melanoma, lung cancer, and other cancers. Several reports have indicated that tumor-infiltrating lymphocytes (TILs) are associated with clinical and histopathologic risk factors in various cancers. However, the role of TILs in esophageal squamous cell carcinoma (ESCC) has not been well studied. This study aimed to investigate the perilesional status of TILs in ESCC and to show associations between TILs and clinical variables...
February 3, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28144151/validation-of-a-novel-prognostic-scoring-system-using-inflammatory-response-biomarkers-in-patients-undergoing-curative-thoracoscopic-esophagectomy-for-esophageal-squamous-cell-carcinoma
#20
Noriyuki Hirahara, Yusuke Fujii, Tetsu Yamamoto, Ryoji Hyakudomi, Takanori Hirayama, Takahito Taniura, Kazunari Ishitobi, Yoshitsugu Tajima
BACKGROUND: Systemic inflammatory markers, including the lymphocyte-to-monocyte ratio, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio have been shown to predict postoperative recurrence and survival in various types of cancer. However, their role in esophageal cancer has yet to be determined. This study aimed to evaluate the prognostic significance of an inflammatory response biomarker (IRB) score, independent of conventional clinicopathological criteria, in patients with esophageal cancer undergoing curative resection...
2017: OncoTargets and Therapy
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