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Eosinophilic gastritis

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https://www.readbyqxmd.com/read/28405320/distinct-metaplastic-and-inflammatory-phenotypes-in-autoimmune-and-adenocarcinoma-associated-chronic-atrophic-gastritis
#1
Sangho Jeong, Eunyoung Choi, Christine P Petersen, Joseph T Roland, Alessandro Federico, Rossana Ippolito, Francesco P D'Armiento, Gerardo Nardone, Osamu Nagano, Hideyuki Saya, Marco Romano, James R Goldenring
BACKGROUND: Autoimmune gastritis (AIG) and adenocarcinoma-associated chronic atrophic gastritis (CAG) are both associated with oxyntic atrophy, but AIG patients demonstrate an increased risk of carcinoid tumors rather than the elevated risk of adenocarcinoma observed with CAG. We therefore sought to compare the characteristics of the metaplastic mucosa in AIG and CAG patients. METHODS: We examined markers for metaplasia (spasmolytic polypeptide expressing metaplasia (SPEM) and intestinal metaplasia) as well as proliferation (Ki67) and immune cell populations (neutrophils, macrophages, and eosinophils) in gastric sections from 16 female patients with autoimmune thyroiditis and AIG and 17 patients with CAG associated with gastric adenocarcinoma...
February 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28338484/the-importance-of-biopsy-sampling-practices-in-the-pathologic-evaluation-of-gastrointestinal-disorders
#2
Nicole C Panarelli, Rhonda K Yantiss
PURPOSE OF REVIEW: To summarize the literature regarding appropriate endoscopic sampling and surveillance protocols for common inflammatory diseases of the digestive tract. Gastroenterologists increasingly use endoscopy with mucosal biopsy to detect inflammatory diseases, assess response to therapy, and monitor for progression to dysplasia. RECENT FINDINGS: Many diseases show a patchy distribution in the digestive tract and there may be poor correlation between the endoscopic appearance and presence of histologic abnormalities...
September 2016: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/28226319/oral-and-sublingual-immunotherapy-potential-causes-for-eosinophilic-gastrointestinal-disorders
#3
REVIEW
Delara Babaie, Mehrnaz Mesdaghi, Makoto Nishino, Mahboubeh Mansouri, Motohiro Ebisawa
Food allergy is a common health problem worldwide, with increasing prevalence during recent decades. The only approved treatments for food allergy are food avoidance and administration of emergency medications in case of accidental exposure, which negatively affects patients' quality of life, so new treatments are highly desirable. Different food immunotherapy modalities have recently been used, with variable success rates in the induction of desensitization and tolerance, and different numbers and types of adverse reactions...
2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28216971/prediction-of-esophageal-and-gastric-histology-by-macroscopic-diagnosis-during-upper-endoscopy-in-pediatric-celiac-disease
#4
Erin D Boschee, Jason Y K Yap, Justine M Turner
AIM: To determine the sensitivity of macroscopic appearance for predicting histological diagnosis at sites other than duodenum in pediatric celiac disease (CD). METHODS: Endoscopic and histologic findings in pediatric patients undergoing upper endoscopy for first-time diagnosis of CD at Stollery Children's Hospital from 2010-2012 were retrospectively reviewed. RESULTS: Clinical charts from 140 patients were reviewed. Esophageal and gastric biopsies were taken in 54...
January 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28118289/utility-of-gastric-and-duodenal-biopsies-during-follow-up-endoscopy-in-children-with-eosinophilic-esophagitis
#5
Sunpreet Kaur, John M Rosen, Alyssa A Kriegermeier, Joshua B Wechsler, Amir F Kagalwalla, Jeffrey B Brown
OBJECTIVES: Eosinophilic esophagitis (EoE) is a chronic antigen-mediated immune disorder of the esophagus. Consensus guidelines recommend obtaining esophageal, gastric and duodenal biopsies at diagnostic endoscopy when EoE is suspected. The utility of repeated gastric and duodenal biopsies during follow-up endoscopy in patients previously diagnosed with EoE is not established. The aim of this study was to explore the role of gastric and duodenal biopsies in children with an established diagnosis of EoE undergoing repeat endoscopy to assess histological response to treatment...
January 21, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28113038/nuclear-glycogen-inclusions-in-canine-parietal-cells
#6
S Silvestri, E Lepri, C Dall'Aglio, M C Marchesi, G Vitellozzi
Nuclear glycogen inclusions occur infrequently in pathologic conditions but also in normal human and animal tissues. Their function or significance is unclear. To the best of the authors' knowledge, no reports of nuclear glycogen inclusions in canine parietal cells exist. After initial observations of nuclear inclusions/pseudoinclusions during routine histopathology, the authors retrospectively examined samples of gastric mucosa from dogs presenting with gastrointestinal signs for the presence of intranuclear inclusions/pseudoinclusions and determined their composition using histologic and electron-microscopic methods...
January 1, 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/27990837/unusual-presentation-of-infection-by-helicobacter-pylori-gastritis-associated-with-russell-bodies-infrequent-and-poorly-understood-pathology
#7
Viviana Parra Vargas, Diego M Aponte, Eligio Antonio Álvarez
Russell bodies gastritis is a very rare disease, with few cases reported in literature, and characterized by the finding of plasma cells with eosinophilic intracytoplasmic inclusions in the gastric mucosa, called Mott cells. Although it has been partnered since its first description to Helicobacter pylori infection, it is important to considered differential diagnoses such as lymphoplasmacytic lymphoma, mucosa-associated lymphoid tissue (MALT) lymphoma, plasmacytoma and signet ring cell carcinom. In this case report, we address a patient with histologic confirmation and her follow up...
January 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/27727140/eosinophilic-esophagitis-demographic-clinical-endoscopic-histological-and-allergological-characteristics-in-children-and-teenagers-in-a-region-of-central-spain
#8
E Gómez Torrijos, P Sánchez Miranda, P Donado Palencia, A Castro Jimenez, J Rodriguez Sánchez, Y Mendez Díaz, L Moreno Lozano, R García Rodríguez
BACKGROUND: Eosinophilic esophagitis (EoE) is a chronic inflammatory emerging disease of the oesophagus with immunoallergic aetiology. Until now, few studies about this disease in children and adolescents have been published Objectives: To study the demographic, clinical, serologic, endoscopic-histological and allergologic characteristics of the patients and their atopic and digestive comorbidities. METHODOLOGY: It is an prospective observacional study in children and adolescents (<16 years) assessed in a multidisciplinary specialized eosinpophilic esopahgitis unit in a tertiary referral centre in the central region of Spain carried out between 2011-2015...
October 10, 2016: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/27478819/the-utility-of-endoscopic-biopsies-in-patients-with-normal-upper-endoscopy
#9
Anouar Teriaky, Abdullah AlNasser, Carolyn McLean, James Gregor, Brian Yan
Background and Aims. Upper endoscopy is a valuable tool in the workup of gastrointestinal (GI) complaints. The purpose of this study is to determine cost and yield of taking biopsies in a normal upper GI tract. Methods. This is a retrospective study where all upper GI biopsies were identified between May 2012 and April 2013, at a tertiary care center. Clinical, procedural, and pathology reports were reviewed to identify patient demographics, procedure information, and pathology diagnosis. Results. Biopsies of the upper GI tract were taken in 1297 patients with normal upper endoscopies...
2016: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27412691/simultaneous-or-sequential-gastrectomy-in-pediatric-liver-transplant-recipients
#10
Karina M O Roda, Eduardo A Fonseca, Helry L Candido, Marcel R Benavides, Rogerio C Afonso, Renata Pugliese, Rodrigo Vincenzi, Paulo Chapchap, Joao Seda Neto
The association between LT and gastrectomy is not common. Only two studies reported the gastrectomy/LT association in children. Here, we report three children who underwent LT who required a concomitant or sequential gastrectomy for different reasons. Patient 1, a 16-yr-old boy, during the LT, underwent a partial gastrectomy due to extensive injury to the duodenum. He had a previous and unusual portoenterostomy performed in the duodenum. Bowel reconstruction was performed using an intestinal loop that was first used for the bilio-enteric anastomosis and then connected to the gastric stump...
November 2016: Pediatric Transplantation
https://www.readbyqxmd.com/read/27259856/regulatory-t-cells-control-th2-dominant-murine-autoimmune-gastritis
#11
Jessica Harakal, Claudia Rival, Hui Qiao, Kenneth S Tung
Pernicious anemia and gastric carcinoma are serious sequelae of autoimmune gastritis (AIG). Our study indicates that in adult C57BL/6-DEREG mice expressing a transgenic diphtheria toxin receptor under the Foxp3 promoter, transient regulatory T cell (Treg) depletion results in long-lasting AIG associated with both H(+)K(+)ATPase and intrinsic factor autoantibody responses. Although functional Tregs emerge over time during AIG occurrence, the effector T cells rapidly become less susceptible to Treg-mediated suppression...
July 1, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27253425/eosinophilic-gastroenteritis-a-state-of-the-art-review
#12
MingMing Zhang, YanQing Li
Eosinophilic gastrointestinal disorders are a series of diseases that include eosinophilic esophagitis, eosinophilic gastritis, eosinophilic gastroenteritis, eosinophilic enteritis, and eosinophilic colitis. Among these disorders, eosinophilic gastroenteritis is an uncommon and heterogeneous disease characterized by eosinophilic infiltration of the gastrointestinal tract in the absence of secondary causes, presenting with a variety of gastrointestinal manifestations. Up to now, epidemiology and pathophysiology of eosinophilic gastroenteritis are still unclear...
January 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27250051/a-possible-case-of-hepatitis-due-to-hypereosinophilic-syndrome
#13
Tomoe Kawamura, Atsushi Hiraoka, Akiko Toshimori, Hidetaro Ueki, Miho Kaneto, Toshihiko Aibiki, Tomonari Okudaira, Hiroka Yamago, Hiromasa Nakahara, Hideomi Tomida, Yoshifumi Suga, Nobuaki Azemoto, Kenichiro Mori, Hideki Miyata, Tomoyuki Ninomiya, Masashi Hirooka, Masanori Abe, Bunzo Matsuura, Yoichi Hiasa, Katsumi Kito, Kojiro Michitaka
A 63-year-old Japanese man whose white blood cell count and total-bilirubin and aminotransferase levels were elevated was referred to our hospital. Computed tomography did not reveal any abnormalities, and there was no evidence of gastritis or colitis on esophagogastroduodenoscopy. Although the patient had no history of drug use or allergies, a high concentration of eosinophils (80%) was noted. A liver biopsy revealed hepatitis with eosinophilic infiltration. The patient's alanine aminotransferase and eosinophil levels improved with the administration of steroids...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27226792/a-player-and-coordinator-the-versatile-roles-of-eosinophils-in-the-immune-system
#14
REVIEW
Hai Long, Wei Liao, Ling Wang, Qianjin Lu
Eosinophils have traditionally been associated with allergic diseases and parasite infection. Research advances in the recent decades have brought evolutionary changes in our understanding of eosinophil biology and its roles in immunity. It is currently recognized that eosinophils play multiple roles in both innate and adaptive immunity. As effector cells in innate immunity, eosinophils exert a pro-inflammatory and destructive role in the Th2 immune response associated with allergic inflammation or parasite infection...
March 2016: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/27191032/pharmacological-treatment-of-eosinophilic-gastrointestinal-disorders
#15
REVIEW
Susan Hua, Dane Cook, Marjorie M Walker, Nicholas J Talley
INTRODUCTION: Eosinophilic gastrointestinal disorders (EGIDs) are increasingly prevalent chronic inflammatory diseases characterized by eosinophilic infiltration of the gastrointestinal (GI) tract, in the absence of other known causes of eosinophilia. AREAS COVERED: Clinical management of EGIDs is challenging, as there are currently limited therapeutic options available. The most common EGID is eosinophilic esophagitis (EoE), and rarer forms are eosinophilic gastritis, eosinophilic gastroenteritis, and eosinophilic colitis...
September 2016: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/26909810/-contact-allergic-gastritis-rare-manifestation-of-a%C3%A2-metal-allergy
#16
REVIEW
C Pföhler, T Vogt, C S L Müller
Only a few cases of contact allergic gastritis in patients with nickel allergy have been reported in the literature. We report a case of probable contact-allergic gastritis in a 46-year-old woman. Clinical examination revealed lichenoid mucosal lesions of the gums adjacent to a bridge and crowns that had been implanted several weeks previously. Since implantation, the patient suffered from gastrointestinal complaints including stomach pain. Gastroscopy and histological investigation of stomach biopsies showed eosinophilic gastritis...
May 2016: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/26889090/wheat-allergy-diagnosis-and-management
#17
REVIEW
Antonella Cianferoni
Triticum aestivum (bread wheat) is the most widely grown crop worldwide. In genetically predisposed individuals, wheat can cause specific immune responses. A food allergy to wheat is characterized by T helper type 2 activation which can result in immunoglobulin E (IgE) and non-IgE mediated reactions. IgE mediated reactions are immediate, are characterized by the presence of wheat-specific IgE antibodies, and can be life-threatening. Non-IgE mediated reactions are characterized by chronic eosinophilic and lymphocytic infiltration of the gastrointestinal tract...
2016: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/26834264/pneumonia-and-gastritis-in-a-cat-caused-by-feline-herpesvirus-1
#18
Glenna F McGregor, Karen Sheehan, Elemir Simko
We report a case of fatal respiratory and gastric herpesvirus infection in a vaccinated, adult cat with no known immunosuppression or debilitation. The disease was characterized by severe necrotizing bronchopneumonia, fibrinonecrotic laryngotracheitis, and multifocal necrotizing gastritis associated with eosinophilic intranuclear inclusion bodies and a large amount of feline herpesvirus-1 antigen detected with immunohistochemistry.
February 2016: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/26709253/eosinophilic-gastrointestinal-disorders-associated-with-autoimmune-connective-tissue-disease
#19
Marie Lecouffe-Desprets, Matthieu Groh, Bruno Bour, Claire Le Jeunne, Xavier Puéchal
OBJECTIVES: To determine the clinical and pathological characteristics of eosinophilic gastrointestinal disease (EGID) associated with autoimmune connective tissue disease (CTD). METHODS: Systematic literature review. RESULTS: Twenty cases of CTD associated with EGID were identified. Systemic lupus erythematosus was the main EGID-associated CTD (35%), followed by rheumatoid arthritis (20%), systemic sclerosis or inflammatory myopathies (15%, each), and Sjögren's syndrome, scleromyositis or other overlapping connective tissue disease (5%, each)...
October 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/26463759/investigation-of-potential-early-histologic-markers-of-pediatric-inflammatory-bowel-disease
#20
Julie A Bass, Craig A Friesen, Amanda D Deacy, Nancy A Neilan, Julia M Bracken, Valentina Shakhnovich, Vivekanand Singh
BACKGROUND: Early manifestations of pediatric inflammatory bowel disease (IBD) can be relatively nonspecific. Initial mucosal biopsies may not be conclusive, delaying the diagnosis until subsequent biopsies demonstrate typical histologic features of IBD. We hypothesized that certain inflammatory cell types may be utilized as early histologic indicators of IBD in children. METHODS: A retrospective analysis compared histologic findings from initially inconclusive or negative endoscopic studies in 22 patients who were subsequently diagnosed with IBD (after diagnostic endoscopy) to those of 20 comparison patients with functional abdominal pain matched for age, gender, and study type...
2015: BMC Gastroenterology
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