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https://www.readbyqxmd.com/read/27833384/fecal-microbiota-in-pouchitis-and-ulcerative-colitis
#1
Kai-Yu Li, Jian-Lin Wang, Jiang-Peng Wei, Sen-Yang Gao, Ying-Ying Zhang, Li-Tian Wang, Gang Liu
AIM: To investigate the changes in microbiota in feces of patients with ulcerative colitis (UC) and pouchitis using genomic technology. METHODS: Fecal samples were obtained from UC patients with or without an ileal pouch-anal anastomosis (IPAA) procedure, as well as healthy controls. The touchdown polymerase chain reaction technique was used to amplify the whole V3 region of the 16S rRNA gene, which was transcribed from DNA extracted from fecal samples. Denaturing gradient gel electrophoresis was used to separate the amplicons...
October 28, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27822614/outcome-and-functional-prognosis-of-pelvic-sepsis-after-ileal-pouch-anal-anastomosis-in-patients-with-ulcerative-colitis
#2
Shozo Ide, Toshimitsu Araki, Yoshiki Okita, Mikio Kawamura, Yuji Toiyama, Minako Kobayashi, Masaki Ohi, Koji Tanaka, Yasuhiro Inoue, Keiichi Uchida, Yasuhiko Mohri, Masato Kusunoki
PURPOSE: Restorative proctocolectomy with ileal pouch-anal anastomosis is a surgical procedure for ulcerative colitis, but pouch failure or pelvic sepsis still occurs in some patients. We conducted this study to investigate the cause of pouch failure and evaluate defecatory function after pelvic sepsis. METHODS: A total of 234 patients who underwent restorative proctocolectomy were enrolled. We analyzed the cause of pouch failure, as well as defecatory function and manometric outcomes, with and without the complication of pelvic sepsis...
November 7, 2016: Surgery Today
https://www.readbyqxmd.com/read/27807581/pouchitis-associated-with-pelvic-radiation-for-prostate-cancer
#3
Geeta Kulkarni, Xiuli Liu, Bo Shen
Radiation therapy is a viable option in managing potentially life-threatening malignancies including prostate cancer. It is known that pelvic radiation can result in injury of the distal large bowel with the development of radiation proctitis. Despite reports from retrospective studies, there is a lack of direct endoscopic and histologic evidence of external pelvic radiation injury to the ileal pouch-anal anastomosis. We present a case of a 68-year-old male with pouchitis resulting from pelvic radiation for prostate cancer...
August 2016: ACG Case Reports Journal
https://www.readbyqxmd.com/read/27807556/ileal-pouch-biopsy-triggers-investigation-and-diagnosis-of-systemic-mastocytosis
#4
Abul Ala Syed Rifat Mannan, Bo Shen, Fred Hsieh, Deepa T Patil
We report a unique case of systemic mastocytosis (SM) diagnosed in an ileal pouch biopsy obtained from a 44-year-old woman with ulcerative colitis. She presented with intermittent abdominal pain and watery diarrhea that did not respond to antibiotic therapy. The pouch biopsy showed expansion of the lamina propria by aggregates of CD117 and CD25-positive abnormal mast cells. A subsequent bone marrow analysis showed an increase in abnormal mast cells. Based on World Health Organization criteria, she was diagnosed with SM and responded to cromolyn sodium therapy...
August 2016: ACG Case Reports Journal
https://www.readbyqxmd.com/read/27785322/common-inflammatory-disorders-and-neoplasia-of-the-ileal-pouch-a-review-of-histopathology
#5
REVIEW
David Hernandez Gonzalo, Amy L Collinsworth, Xiuli Liu
Ileal pouch-anal anastomosis (IPAA) is the standard restorative procedure after proctocolectomy in patients with ulcerative colitis (UC) who require colectomy. The ileal pouch is susceptible to a variety of insults including mechanical injury, ischemia, fecal stasis, and infectious agents. In addition, the development of recurrent and idiopathic inflammatory bowel disease and neoplasia may occur in the ileal pouch. Although clinical, endoscopic, and radiographic examination can diagnose many ileal pouch diseases, histologic examination plays an essential role in diagnosis and management, particularly in cases with antibiotic refractory chronic pouchitis and pouch neoplasia...
June 2016: Gastroenterology Research
https://www.readbyqxmd.com/read/27769810/roles-for-intestinal-bacteria-viruses-and-fungi-in-pathogenesis-of-inflammatory-bowel-diseases-and-therapeutic-approaches
#6
R Balfour Sartor, Gary D Wu
Intestinal microbiota are involved in the pathogenesis of Crohn's disease, ulcerative colitis, and pouchitis. We review the mechanisms by which these gut bacteria, fungi, and viruses mediate mucosal homeostasis, via their composite genes (metagenome) and metabolic products (metabolome). We explain how alterations to their profiles and functions under conditions of dysbiosis contribute to inflammation and effector immune responses that mediate inflammatory bowel diseases (IBD) in humans and enterocolitis in mice...
October 18, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27769076/the-role-of-dietary-supplements-in-inflammatory-bowel-disease-a-systematic-review
#7
Roberta E Rossi, Tara Whyand, Charles D Murray, Mark I Hamilton, Dario Conte, Martyn E Caplin
Inflammatory bowel diseases (IBD) are chronic immune disorders of unclear aetiology. Dietary deficiencies may be a potential pathogenic factor in their development. Patients often take food supplements without knowledge of any evidence base. We have therefore assessed the evidence for food supplementation in the management of IBD. A PubMed search was performed for the terms Inflammatory bowel disease; nutritional deficiencies; dietary supplements; curcumin; green tea; vitamin D/other vitamins; folic acid; iron; zinc; probiotics; andrographis paniculata; and boswellia serrate...
December 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27741172/probiotics-and-liver-disease-where-are-we-now-and-where-are-we-going
#8
Abdel-Naser Elzouki
Probiotics are live, nonpathogenic bacteria capable of colonizing the colonic mucosa. The most common probiotics include strains of Lactobacillus or Bifidobacteria, which are part of the normal gastrointestinal microbiota. Initial studies of selected probiotic species have suggested potential efficacy in several gastrointestinal diseases including inflammatory bowel diseases (particularly pouchitis), antibiotic-related diarrhea, Clostridium difficile toxin-induced colitis, infectious diarrhea, irritable bowel syndrome, and allergy...
November 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27688067/the-prevalence-of-chronic-peri-pouch-sepsis-in-patients-treated-for-antibiotic-dependent-or-refractory-primary-idiopathic-pouchitis
#9
V A van der Ploeg, Y Maeda, O D Faiz, A L Hart, S K Clark
AIM: Chronic peri-pouch sepsis (CPPS) may be mistaken for antibiotic-dependent or refractory primary idiopathic pouchitis (ADRP), but requires different treatment such as drainage. The study aimed to identify the prevalence of CPPS in patients thought to have ADRP. The secondary aims were to identify any specific features on pouchoscopy suggesting CPPS and to determine the results of treatment for CPPS. METHOD: The records of patients who had been treated for ADRP between March 2006 and June 2015 were reviewed retrospectively...
September 30, 2016: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/27682647/ileal-pouch-anal-anastomosis-20%C3%A2-years-later-is-it-still-a-good-surgical-option-for-patients-with-ulcerative-colitis
#10
Gentilini Lorenzo, Coscia Maurizio, Lombardi Pietro Maria, Marta Tanzanu, Laureti Silvio, Podda Mariangela, Poggioli Gilberto
PURPOSE: Short-term results after ileo-pouch anal anastomosis (IPAA) are well established; data are conflicting in long-standing patients. We retrospectively evaluated long-term complications and functional results after follow-up longer than 20 years. METHODS: Two hundred five patients with follow-up longer than 20 years have been identified out of 1112 IPAA performed in our institution; of these, 20 cases were lost at follow-up or decline to take part at the study...
September 28, 2016: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/27681447/pouchitis-after-ileal-pouch-anal-anastomosis-in-ulcerative-colitis-diagnosis-management-risk-factors-and-incidence
#11
Keisuke Hata, Soichiro Ishihara, Hiroaki Nozawa, Kazushige Kawai, Tomomichi Kiyomatsu, Toshiaki Tanaka, Junko Kishikawa, Hiroyuki Anzai, Toshiaki Watanabe
Restorative proctocolectomy with ileal pouch-anal anastomosis has been the surgical treatment of choice for patients with ulcerative colitis who require surgery. The quality of life after this procedure is satisfactory in most cases; however, pouchitis is a troublesome condition involving inflammation of the ileal pouch. When a patient presents with symptoms of pouchitis, such as increased bowel movements, mucous and/or bloody exudates, abdominal cramps, and fever, endoscopy is essential for a precise diagnosis...
September 28, 2016: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/27666926/postoperative-excessive-gain-in-visceral-adipose-tissue-as-well-as-body-mass-index-are-associated-with-adverse-outcomes-of-an-ileal-pouch
#12
Ganglei Liu, Xianrui Wu, Yi Li, Yuanyi Rui, Luca Stocchi, Feza H Remzi, Bo Shen
BACKGROUND: There are no published studies on the impact of visceral adipose tissue (VAT) change on outcomes of restorative proctocolectomy and ileal pouch-anal anastomosis (IPAA). The aim of this historic cohort study was to evaluate the impact of excessive VAT gain on the outcomes of inflammatory bowel disease (IBD) patients with IPAA. METHODS: We evaluated all eligible patients with at least two sequential CT scans after pouch construction from our prospectively maintained Pouchitis Registry between 2002 and 2014...
September 25, 2016: Gastroenterology Report
https://www.readbyqxmd.com/read/27633133/an-update-on-probiotics-prebiotics-and-symbiotics-in-clinical-nutrition
#13
Gabriel Olveira, Inmaculada González-Molero
The concept of prebiotics, probiotics, and symbiotics and their use in different situations of daily clinical practice related to clinical nutrition is reviewed, as well as their role in the treatment/prevention of diarrhea (acute, induced by antibiotics, secondary to radiotherapy), inflammatory bowel disease (ulcerative colitis and pouchitis), in colonic health (constipation, irritable bowel), in liver disease (steatosis and minimum encephalopathy), and in intensive care, surgical, and liver transplantation...
November 2016: Endocrinología y Nutrición: órgano de la Sociedad Española de Endocrinología y Nutrición
https://www.readbyqxmd.com/read/27621567/modulation-of-microbiota-as-treatment-for-intestinal-inflammatory-disorders-an-uptodate
#14
REVIEW
Antonella Gallo, Giovanna Passaro, Antonio Gasbarrini, Raffaele Landolfi, Massimo Montalto
Alterations of intestinal microflora may significantly contribute to the pathogenesis of different inflammatory and autoimmune disorders. There is emerging interest on the role of selective modulation of microflora in inducing benefits in inflammatory intestinal disorders, by as probiotics, prebiotics, synbiotics, antibiotics, and fecal microbiota transplantation (FMT). To summarize recent evidences on microflora modulation in main intestinal inflammatory disorders, PubMed was searched using terms microbiota, intestinal flora, probiotics, prebiotics, fecal transplantation...
August 28, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27613294/alterations-of-enteric-microbiota-in-patients-with-a-normal-ileal-pouch-are-predictive-of-pouchitis
#15
Nitsan Maharshak, Nathaniel Aviv Cohen, Leah Reshef, Hagit Tulchinsky, Uri Gophna, Iris Dotan
OBJECTIVE: To examine whether patients with a mature normal pouch (>1 year post-ileostomy closure) have microbial stool characteristics that can predict pouch inflammation. DESIGN: Patients undergoing pouch surgery were recruited prospectively. Microbiota analysis of fecal samples was by 16S rRNA gene pyrosequencing. All patients had a normal pouch at baseline (T1). Those without pouchitis during the first year of follow-up (T2) comprised the "Normal Pouch-sustained" group and those who had experienced an episode of pouchitis comprised the "Pre-Pouchitis" group...
September 9, 2016: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/27602702/pouchitis-in-pediatric-ulcerative-colitis-patients-after-ileal-pouch-anal-anastomosis
#16
Keiichi Uchida, Yoshiki Okita, Toshimitsu Araki, Masato Kusunoki
No abstract text is available yet for this article.
December 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27574882/predictors-of-pouchitis-after-ileal-pouch-anal-anastomosis-in-children
#17
Rajmohan Dharmaraj, Mahua Dasgupta, Pippa Simpson, Joshua Noe
No abstract text is available yet for this article.
December 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27569889/role-of-intestinal-flora-imbalance-in-pathogenesis-of-pouchitis
#18
Xiao-Bo Feng, Jun Jiang, Min Li, Gang Wang, Jin-Wei You, Jian Zuo
OBJECTIVE: To discuss the role of intestinal flora imbalance in the pathogenesis of pouchitis. METHODS: The pouchitis rat model was established and the faeces sample and the mucous membrane sample were collected regularly, in which the bacterial nucleic acids were extracted for quantitative analysis of the intestinal flora in the samples through using the real-time quantitative PCR technique and high energy sequencing technology. RESULTS: The disorder phenomenon of the intestinal flora appeared at the 7th day of the experiment, and the pouchitis was presented at the 21st day of the experiment...
August 2016: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/27555972/campylobacter-pouchitis-mimicking-the-appearance-of-crohn-s-disease
#19
Greg S Cohen, Meena Prasad
An unusual case of campylobacter pouchitis resembling the endoscopic appearance of Crohn's disease is reported.
2016: Case Reports in Gastrointestinal Medicine
https://www.readbyqxmd.com/read/27554912/review-article-the-pathogenesis-of-pouchitis
#20
REVIEW
K M Schieffer, E D Williams, G S Yochum, W A Koltun
BACKGROUND: A total proctocolectomy followed by ileal pouch-anal anastomosis is a potentially curative surgery for ulcerative colitis or familial adenomatous polyposis. About 5-35% of patients with ulcerative colitis and 0-11% of patients with familial adenomatous polyposis develop subsequent inflammation of the ileal pouch termed pouchitis. AIM: To provide a comprehensive analysis of the research studying the possible pathogenesis of pouchitis. The goals were to identify promising areas of investigation, to help focus clinicians, researchers and patients on how to better understand and then potentially manage ileal pouchitis, and to provide avenues for future research investigations...
October 2016: Alimentary Pharmacology & Therapeutics
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