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JOURNAL ARTICLE
Vincent P Anto, Anna E Ramos, Kevin P Mollen
Pouchitis is defined as inflammation of the ileal pouch created during a restorative proctocolectomy with ileal pouch-anal anastomosis. Although the incidence of this inflammatory condition is high, the exact etiology often remains unclear and the management challenging. In this review, we summarize the clinical presentation, pathogenesis, diagnosis, and management of this common complication.
March 28, 2024: Seminars in Pediatric Surgery
#2
JOURNAL ARTICLE
Yukako Nemoto, Shinya Tajima, Kota Saito, Arata Satoi, Takashi Matsui, Sei Kimura, Fumihiko Nakamura
Pouchitis is the most common long-term complication following ileal pouch-anal anastomosis (IPAA) in patients with ulcerative colitis. Although several agents, including probiotics, steroids, and immunomodulators, have been used, the treatment of pouchitis remains challenging. Owing to the proven efficacy of biological therapy in inflammatory bowel disease, there is now growing evidence suggesting the potential benefits of biological therapy in refractory pouchitis. Here, we report the case of a 64-year-old woman with pouchitis due to ulcerative colitis who was successfully treated with ustekinumab (UST)...
2024: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
#3
REVIEW
Giammarco Mocci, Antonio Tursi, Francesca Maria Onidi, Paolo Usai-Satta, Giovanni Mario Pes, Maria Pina Dore
Inflammatory bowel diseases, comprising Crohn's disease (CD) and ulcerative colitis (UC), are chronic, relapsing, and remitting immune-mediated inflammatory diseases affecting the gastrointestinal tract. Ustekinumab (UST) is a monoclonal antibody that blocks the p40 subunit of the anti-interleukin (IL) 12/23. Pivotal trials (CERTIFI and UNITI-IM for CD, UNIFI for UC) established the efficacy of UST for the induction and maintenance of remission in both CD and UC, with the most favorable results in naïve patients to biologics...
March 6, 2024: Journal of Clinical Medicine
#4
JOURNAL ARTICLE
Edward L Barnes, Anastasia Karachalia Sandri, Hans H Herfarth, Tine Jess
BACKGROUND & AIMS: Pouchitis is the most common complication after ileal pouch-anal anastomosis (IPAA) for ulcerative colitis (UC), however clinical and environmental risk factors for pouchitis remain poorly understood. We explored the relationship between specific clinical factors and the incidence of pouchitis. METHODS: We established a population-based cohort of all adult persons in Denmark undergoing proctocolectomy with IPAA for UC from 1996-2020. We used Cox Proportional Hazard modeling to assess the impact of antibiotic, non-steroidal anti-inflammatory drug (NSAID) exposure, and appendectomy on diagnosis of acute pouchitis in the first 2 years after IPAA surgery...
March 29, 2024: Clinical Gastroenterology and Hepatology
#5
REVIEW
Evangelia Xenopoulou, Ioanna Kontele, Theodoros N Sergentanis, Maria G Grammatikopoulou, Milia Tzoutzou, Konstantinos Kotrokois, Artemis Κ Tsitsika, Tonia Vassilakou
Recently, there has been an increasing interest in the association of gut microbiota with health conditions and the potentially beneficial role of several types of biotics in several population groups, including children and adolescents. Children and adolescents comprise a unique population group due their rapid growth rates, high nutritional requirements, the immaturity of their immune system in early life, and their susceptibility to infectious diseases. The aim of the present study is to investigate the role and limitations of the administration of biotics in specific conditions affecting children and adolescents...
March 9, 2024: Children
#6
JOURNAL ARTICLE
Hannah Posner, Rachel Lombard, Shintaro Akiyama, Nathaniel A Cohen, David T Rubin, Marla C Dubinsky, Sushila Dalal, Maia Kayal
INTRODUCTION: To better inform the risk of cuffitis in patients with ulcerative colitis (UC), we aimed to identify its occurrence and associated precolectomy factors in a large multicenter cohort of patients who underwent restorative proctocolectomy (RPC) with stapled ileal pouch-anal anastomosis (IPAA). METHODS: This study was a retrospective cohort analysis of individuals diagnosed with UC or indeterminate colitis who underwent RPC with IPAA for refractory disease or dysplasia at Mount Sinai Hospital or the University of Chicago followed by at least 1 pouchoscopy with report of the pouch-anal anastomosis...
March 23, 2024: Inflammatory Bowel Diseases
#7
REVIEW
Meghan M Baske, Kiara C Timmerman, Lucas G Garmo, Megan N Freitas, Katherine A McCollum, Tom Y Ren
BACKGROUND: The gut-brain-axis has a role in mental health disorders. In people with generalized anxiety disorder, GAD,1 normal flora Escherichia-Shigella, are significantly elevated. Fecal microbiota transplant, FMT,2 has been used to alter the gut composition in unhealthy individuals. There may be a role for FMT in the treatment of GAD to improve the gut-brain-axis. METHODS: A systematic review of literature was conducted on articles published in PubMed, CINAHL Plus, Scopus, Cochrane Library, and Wed of Science from 2000 to 2022 that analyzed FMT as a modality to alter the gut microbiome in which Escherichia-Shigella levels were quantified and reported...
March 16, 2024: Journal of Affective Disorders
#8
JOURNAL ARTICLE
Chun-Ting Lin, James Cheng-Chung Wei
No abstract text is available yet for this article.
March 8, 2024: American Journal of Gastroenterology
#9
JOURNAL ARTICLE
Arafa Djalal, Serre-Yu Wong, Jean-Frédéric Colombel, Ryan Ungaro, Maia Kayal
No abstract text is available yet for this article.
April 2024: Digestive Diseases and Sciences
#10
JOURNAL ARTICLE
Francisco Mesonero, Yamile Zabana, Agnès Fernández-Clotet, Eduardo Leo-Carnerero, Berta Caballol, Andrea Núñez-Ortiz, María José García, Federico Bertoletti, Alejandro Mínguez, Gerard Suris, Begoña Casis, Rocío Ferreiro-Iglesias, Margalida Calafat, Itxaso Jiménez, José Miranda-Bautista, Luis Javier Lamuela, Ingrid Fajardo, Leyanira Torrealba, Rodrigo Nájera, Rosa María Sáiz-Chumillas, Irene González, Miren Vicuña, Natalia García-Morales, Ana Gutiérrez, Alicia López-García, José Manuel Benítez, Cristina Rubín de Célix, Coral Tejido, Eduard Brunet, Alejandro Hernández-Camba, Cristina Suárez, Iago Rodríguez-Lago, Marta Piqueras, Andrés Castaño, Laura Ramos, Ana Sobrino, María Carmen Rodríguez-Grau, Alfonso Elosua, Miguel Montoro, Ruth Baltar, José María Huguet, Benito Hermida, Antonio Caballero-Mateos, Luis Sánchez-Guillén, Abdel Bouhmidi, Ramón Pajares, Iria Baston-Rey, Antonio López-Sanromán, Agustin Albillos, Manuel Barreiro-de Acosta
BACKGROUND: The usefulness of thiopurines has been poorly explored in pouchitis and other pouch disorders. OBJECTIVE: To evaluate the effectiveness and safety of azathioprine as maintenance therapy in inflammatory pouch disorders. DESIGN: This was a retrospective and multicentre study. METHODS: We included patients diagnosed with inflammatory pouch disorders treated with azathioprine in monotherapy. Effectiveness was evaluated at 1 year and in the long term based on normalization of stool frequency, absence of pain, faecal urgency or fistula discharge (clinical remission), or any improvement in these symptoms (clinical response)...
2024: Therapeutic Advances in Gastroenterology
#11
Mili Shah, Aarshdeep Masson, Hamsika Moparty, Dhir Gala, Vikash Kumar
Patients who undergo restorative proctocolectomy and ileoanal anastomosis can develop pouchitis as a common chronic complication. A rare subset of patients fails to respond to multiple antibiotic therapies and develop chronic antibiotic-refractory pouchitis (CARP). We present a case of a 45-year-old male with pouchitis refractory to chronic antibiotic therapy and histology demonstrating chronic inflammatory changes. Management involved mesalamine and probiotics, resulting in a positive clinical response and symptom absence on follow-up...
February 2024: Curēus
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JOURNAL ARTICLE
Padmini Nallapaneni, Joseph A Picoraro
BACKGROUND: Restorative proctocolectomy and ileal pouch anal anastomosis has become the surgical procedure of choice in pediatric patients with medically-refractory ulcerative colitis or familial adenomatous polyposis. This systematic review aims to assess the diagnosis and treatment of pouch disorders in pediatric patients who undergo ileal pouch anal anastomosis. METHODS: A literature search was performed on MEDLINE, Google Scholar and EMBASE for all publications describing outcomes of pediatric ileal pouch anal anastomosis...
February 28, 2024: Diseases of the Colon and Rectum
#13
JOURNAL ARTICLE
Huaibin Mabel Ko
BACKGROUND: Ileal pouch-anal anastomosis is often required for patients with ulcerative colitis or familial adenomatous polyposis after colectomy. This procedure reduces but does not completely eliminate the risk of neoplasia. OBJECTIVE: This study focuses on the histopathology of neoplasia in the ileal pouch, rectal cuff, and anal transition zone. DATA SOURCES: We performed a Medline search for English language studies published between 1981 and 2022 using the PubMed search engine...
February 29, 2024: Diseases of the Colon and Rectum
#14
JOURNAL ARTICLE
Bo Shen, QingPing Yao, Ellen Scherl
BACKGROUND: Restorative proctocolectomy with ileal pouch-anal anastomosis improves the quality of life in patients with ulcerative colitis by the removal of diseased large bowel and preservation of the natural route of defecation. Although the surgery may improve preexisting extraintestinal manifestations in the joint, skin, and eyes, extraintestinal manifestations, particularly primary sclerosing cholangitis can persist after colectomy. OBJECTIVES: A systemic review of diagnosis and treatment of liver, joint, skin, and eye manifestations in patients with restorative proctocolectomy and ileal pouch-anal anastomosis for ulcerative colitis...
February 27, 2024: Diseases of the Colon and Rectum
#15
REVIEW
Mohamed Ali Chaouch, Mohammad Iqbal Hussain, Amine Gouader, Bassam Krimi, Alessandro Mazzotta, Adriano Carneira Da Costa, Niccolo Petrucciani, Mehdi Bouassida, Jim Khan, Faouzi Noomen, Hani Oweira
PURPOSE: This systematic review and meta-analysis aimed to compare outcomes between stapled ileal pouch-anal anastomosis (IPAA) and hand-sewn IPAA with mucosectomy in cases of ulcerative colitis and familial adenomatous polyposis. METHODS: This systematic review and meta-analysis was performed according to the Preferred Reporting Items for Systematic Review and Meta-analysis) guidelines 2020 and AMSTAR 2 (Assessing the methodological quality of systematic reviews) guidelines...
2024: Cancer Control: Journal of the Moffitt Cancer Center
#16
Anne F Peery, Colleen R Kelly, Dina Kao, Byron P Vaughn, Benjamin Lebwohl, Siddharth Singh, Aamer Imdad, Osama Altayar
BACKGROUND & AIMS: Fecal microbiota-based therapies include conventional fecal microbiota transplant and US Food and Drug Administration-approved therapies, fecal microbiota live-jslm and fecal microbiota spores live-brpk. The American Gastroenterological Association (AGA) developed this guideline to provide recommendations on the use of fecal microbiota-based therapies in adults with recurrent Clostridioides difficile infection; severe to fulminant C difficile infection; inflammatory bowel diseases, including pouchitis; and irritable bowel syndrome...
March 2024: Gastroenterology
#17
REVIEW
Daya K Jha, Shubhra Mishra, Usha Dutta, Vishal Sharma
There is abundant literature reporting about the use of antibiotics in inflammatory bowel disease (IBD), but their role in the management of IBD is not entirely clear. Diverse infectious organisms have been implicated in the pathogenesis of Crohn's disease. Also, infections are believed to be a trigger for flares of ulcerative colitis. The benefit of the routine use of antibiotics in IBD is equivocal. However, there are certain situations, where antibiotics have a clear role and evidence of benefit: perianal fistula, intra-abdominal abscesses in Crohn's disease, acute pouchitis and infection-related flares...
February 2024: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
#18
JOURNAL ARTICLE
Andrew T Weber, Gary R Lichtenstein
BACKGROUND: Chronic antibiotic refractory pouchitis after restorative proctocolectomy with ileal pouch-anal anastomosis, characterized by at least 4 weeks of pouchitis symptoms that have not responded to standard antibiotic therapy, presents a therapeutic challenge for patients and healthcare providers. OBJECTIVE: The aim of this narrative review was to summarize the current evidence regarding management of chronic antibiotic refractory pouchitis. DATA SOURCES: Studies were identified through search of PubMed database from the National Library of Medicine...
February 16, 2024: Diseases of the Colon and Rectum
#19
JOURNAL ARTICLE
Dakota Rhys-Jones, Chu K Yao, Zaid S Ardalan
No abstract text is available yet for this article.
January 2024: Crohn's & colitis 360
#20
JOURNAL ARTICLE
Shintaro Akiyama, Tsubasa Onoda, Shoko Moue, Noriaki Sakamoto, Taku Sakamoto, Hideo Suzuki, Tsuyoshi Enomoto, Daisuke Matsubara, Tatsuya Oda, Kiichiro Tsuchiya
BACKGROUND/AIMS: Mucosal adaptation of the ileum toward colonic epithelium has been reported in pouchitis in ulcerative colitis (UC); however, the clinical characteristics, endoscopic findings, and outcomes in patients with pouchitis with ileal mucosal adaptation are poorly understood. METHODS: This was a single-center retrospective study comprising UC patients treated by proctocolectomy with ileal pouch-anal anastomosis who had undergone pouchoscopy at the University of Tsukuba Hospital between 2005 and 2022...
January 2024: Intestinal Research
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