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Signet ring cell adenocarcinoma

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https://www.readbyqxmd.com/read/28214210/pathologic-features-of-colorectal-carcinomas-associated-with-crohn-s-disease-in-korean-population
#1
Jiyoon Kim, Ho-Su Lee, Sang Hyoung Park, Suk-Kyun Yang, Byong Duk Ye, Dong-Hoon Yang, Kyung-Jo Kim, Jeong-Sik Byeon, Yong Sik Yoon, Chang Sik Yu, Jihun Kim
BACKGROUND: Colorectal cancer (CRC) has been known to complicate Crohn's disease (CD). Several reports in Western population revealed that CRC in CD were characterized by much younger onset and equal distribution of tumors along the entire colon. However, clinicopathologic features of CD-associated CRC in Korean population have not been well documented yet. METHODS: Among 2968 Korean CD patients, 16 patients (0.54%) were found to develop CRC during follow up. We reviewed clinicopathologic features of the 16 CRC patients...
December 21, 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28211282/signet-ring-cell-carcinoma-of-the-jejunum-an-uncommon-finding-within-the-reach-of-capsule-endoscopy
#2
José Francisco Juanmartiñena, Marta Montes, Ignacio Fernández-Urién
An 80 year-old female presented with ductal breast carcinoma (stage II) three years ago, complained of asthenia and iron-deficiency anemia. No diagnosis was obtained after conventional endoscopy and iron supplements were indicated. Ten months later visible digestive hemorrhage was presented. Upper and lower endoscopy was repeated but non-diagnosis was obtained. Thus, video capsule endoscopy was indicated identifying a stenotic lesion arising in the mucosa of distal jejunum. Histopathological examination revealed a poorly mucinous differentiated signet-ring cell adenocarcinoma with an intense peri-tumoral lymphoid (Crohn´s-like lymphoid reaction) and lympho-vascular infiltration with no nodal metastases (pT3N0;7ª edition TNM classification)...
February 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28195245/ependymoma-with-diffuse-signet-ring-features-report-of-a-case-and-review-of-the-literature
#3
L Cima, S Beccari, C Ghimenton, G Pinna, A Beltramello, M Chilosi, M Brunelli, A Eccher
Signet-ring cell ependymoma is a rare variant of ependymoma with only seven cases described in literature. Biological behavior and prognosis of this entity are not well-known until now. We present a case of a 49-year-old female with a history of headache and gait instability. Magnetic resonance imaging showed an upper cervical tumor with cystic component and mural nodule. The patient underwent surgery. Microscopically some cells displayed an eccentric nucleus compressed to the periphery by vacuolated cytoplasm...
March 2016: Pathologica
https://www.readbyqxmd.com/read/28182089/a-rare-case-of-signet-ring-cell-lymphoma-diagnosis-aided-by-immunofluorescent-staining
#4
Charusheela R Gore, N K Panicker, Harsh Kumar, Archana Buch, S S Chandanwale
Signet ring cell lymphomas are the proliferations of malignant lymphoid cells containing cytoplasmic vacuoles or globules which displace the nuclei, imparting it a signet ring appearance. This rare tumor is a variant of non-Hodgkin lymphoma. Signet ring appearance is due to cytoplasmic accumulation of immunoglobulin or vacuoles derived from multivesicular bodies. These cells, particularly with cytoplasmic vacuoles, may be mistaken for adenocarcinoma cells. We are presenting one such case where immunofluorescence helped us to demonstrate the immunoglobulins on fine needle aspiration smears...
January 2017: Journal of Cytology
https://www.readbyqxmd.com/read/28178894/adenocarcinoma-of-the-lung-metastatic-to-the-ovary-with-a-signet-ring-cell-component
#5
Giovanna Giordano, Nelly Cruz Viruel, Enrico Maria Silini, Francisco F Nogales
A nonsmoker 45-year-old woman, presented with a solid right ovarian mass. Microscopic examination revealed heterogeneous histology with tubular formations and extensive signet ring cell component that resembled the usual appearance of metastatic gastric carcinoma to the ovary. Moreover, the histology also showed solid nests of cells with a microvacuolated basophilic cytoplasm similar to those found in adenosquamous cervical carcinoma of glassy cell type. However, analysis of the patient's past history revealed a lung adenocarcinoma, diagnosed 4 years before, which prompted an immunohistochemical differential diagnosis, showing a strong expression for TTF-1 and Napsin A...
February 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28163293/a-case-of-poorly-differentiated-mucinous-carcinoma-of-the-gallbladder-that-exhibited-a-peculiar-morphology
#6
Takahiro Urata, Michiko Nagamine, Naotaka Kugiyama, Kana Noda, Ryo Ichikawa, Masataka Takeguchi, Kazuhito Yoshimoto, Nobuhiro Minami, Hideki Kitada, Yoshi Takekuma
A 65-year-old female presented with an elevated lesion that was identified in the gallbladder fundus via abdominal ultrasound during a medical checkup. The tumor was a pedunculated lesion, measuring 30mm in diameter, that exhibited a blood flow pattern with gradual dense staining throughout the equilibrium phase on the abdominal contrast computed tomography and a high signal intensity on T2-weighted magnetic resonance imaging. Histopathological findings revealed the proliferation of poorly differentiated adenocarcinoma, including signet ring cells, throughout the tumor along with the formation of a mucous lake...
2017: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/28119270/distribution-of-gastric-carcinoma-in-an-area-with-a-high-prevalence-of-helicobacter-pylori
#7
Javed Yakoob, Syeda Sadia Fatima, Zaigham Abbas, Syed Farrukh Mustafa, Hamza Abdur Rahim Khan, Muhammad Faraz Raghib, Safia Awan, Zubair Ahmad
BACKGROUND/AIMS: South Asia is an enigma for gastric cancer (GC) because it is a low risk region with a high prevalence of Helicobacter pylori (H. pylori) infections. We evaluated the trend of GC clinical presentation and risk factors in patients with dyspeptic symptoms. MATERIALS AND METHODS: The medical records of patients, coded by the international classification of diseases (ICD-10-CM, 2015, Diagnosis Code C16.9) for malignancies of stomach diagnosed by esophagogastroduodenoscopy (EGD) and histopathology, were studied...
January 25, 2017: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/28116561/prognostic-impact-of-different-histological-types-on-gastric-adenocarcinoma-a-surveillance-epidemiology-and-end-results-database-analysis
#8
Kaitai Liu, Juefeng Wan, Yanping Bei, Xue Chen, Miaozhen Lu
The clinicopathological characteristics and prognosis of gastric mucinous adenocarcinoma (MAC) and signet ring cell carcinoma (SRC) are still controversial. We designed our study to evaluate the clinicopathologic features and prognosis of MAC, SRC and ordinary gastric adenocarcinoma (OGAC) by analyzing the Surveillance, Epidemiology, and End Results (SEER)-registered database. The 5-year overall survival (OS) of patients with SRC was significantly lower than that of patients with MAC (P = 0.001) and OGAC (P < 0...
January 23, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28097624/poorly-differentiated-adenocarcinoma-with-signet-ring-cells-in-duodenal-papilla-a-case-report
#9
Yuta Ushida, Kiyoshi Hiramatsu, Satomi Saeki, Takeshi Amemiya, Hidenari Goto, Toshiyuki Arai
An 82-year-old woman with common bile duct (CBD) dilatation observed during routine ultrasonography was referred to our hospital. Preliminary blood tests revealed elevated levels of hepatobiliary enzymes. Computed tomography (CT) scan showed lower bile duct wall thickening and enhancement. Esophagogastroduodenoscopy revealed mildly swollen papilla of Vater, without ulceration. Endoscopic retrograde cholangiography demonstrated that the CBD was grossly dilated with a constriction in the lower part. The final diagnosis indicated poorly differentiated adenocarcinoma of duodenal papilla with signet-ring cells; pT3N0M0, stage IIA (Unio Internationalis Contra Cancrum, 7th edition), for which subtotal stomach-preserving pancreaticoduodenectomy (SSPPD) was performed...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28078130/radiographic-and-endoscopic-regression-of-metastatic-gastric-cancer-to-the-colon-in-the-setting-of-5-aminosalicylic-acid-use
#10
Yuval A Patel, Shannon J McCall, Xuefeng Zhang, Tracy Jaffe, Rahul A Shimpi
Colonic metastases from gastric cancer are a rare phenomenon and sparsely reported in the literature. We report a case of a 59-year-old woman who presented with vague abdominal symptoms and initial computer tomography (CT) imaging suggestive of a colonic apple-core lesion with serial colonoscopic biopsies diagnostic of metastatic signet ring cell gastric adenocarcinoma. This case is unique given the evolving CT and endoscopic findings that suggested a regression in colonic wall thickening in the setting of 5-aminosalicylic acid (5-ASA) use prior to histologic diagnosis...
December 2016: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28050437/a-rare-case-of-an-adult-with-untreated-bladder-exstrophy-presenting-with-signet-ring-cell-adenocarcinoma-of-urinary-bladder
#11
Abhishek J Savalia, Vikash Kumar, Gaurav Kasat, Ajit Sawant
Untreated bladder exstrophy in an adult is rare, as the defect is obvious and primary reconstruction is usually done in infancy. There are less than 90 reported cases of primary adenocarcinoma in an untreated bladder exstrophy in literature and only two such case reports from India. Of these, only one case was of signet-ring cell type of mucinous adenocarcinoma. Here we report the second case of signet-ring cell adenocarcinoma in a 63 year old male with untreated bladder exstrophy (oldest patient in literature), to highlight the extreme rarity, yet distinct possibility and challenges faced in surgical management of such cases...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28025627/patients-with-acromegaly-presenting-with-colon-cancer-a-case-series
#12
Murray B Gordon, Samer Nakhle, William H Ludlam
Introduction. Frequent colonoscopy screenings are critical for early diagnosis of colon cancer in patients with acromegaly. Case Presentations. We performed a retrospective analysis of the incidental diagnoses of colon cancer from the ACCESS trial (ClinicalTrials.gov identifier: NCT01995734). Colon cancer was identified in 2 patients (4.5%). Case  1 patient was a 36-year-old male with acromegaly who underwent transsphenoidal surgery to remove the pituitary adenoma. After surgery, the patient underwent routine colonoscopy screening, which revealed a 40 mm tubular adenoma in the descending colon...
2016: Case Reports in Endocrinology
https://www.readbyqxmd.com/read/27898475/pulmonary-signet-ring-cell-adenocarcinoma-metastatic-to-the-skin
#13
Alan S Boyd
Internal malignancies occasionally metastasize to the skin, usually imparting a poor prognosis. In men, pulmonary malignancies are the second most common offending tumor. Roughly, half such lesions are adenocarcinomas. A small subset of pulmonary adenocarcinomas exhibits signet-ring morphology. To date, a cutaneous metastasis arising from a pulmonary signet-ring cell adenocarcinoma has not been reported.
November 23, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27891398/an-unusual-evolution-of-krukenberg-tumour-a-case-report
#14
Claudio Spinelli, Concetta Liloia, Jessica Piscioneri, Clara Ugolini, Silvia Strambi
Krukenberg tumours are rare metastatic tumours of the ovaries characterized by the presence of mucin-producing neoplastic Signet Ring Cell Carcinoma (SRCC). At first glance, this tumour may be confused with a primary ovarian tumour. Surgery and chemotherapy combination have led to improvement in prognosis, but it still remains severe. We report the case of a 60-year-old woman with a Krukenberg tumour rising from a low differentiated gastric adenocarcinoma. The patient was clinically stable for 26 months after surgery until she experienced a prompt decline and died of cerebral haemorrhage within two weeks...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27875858/contemporary-rates-of-pathological-features-and-mortality-for-adenocarcinoma-of-the-urinary-bladder-in-the-usa
#15
Emanuele Zaffuto, Stéphanie Gazdovich, Sami-Ramzi Leyh-Bannurah, Hartwig Huland, Firas Abdollah, Shahrokh F Shariat, Mani Menon, Alberto Briganti, Francesco Montorsi, Pierre I Karakiewicz
OBJECTIVES: To examine contemporary rates of pathological features and mortality for adenocarcinoma of the urinary bladder in the USA using population-based data analysis. METHODS: We relied on 10 024 patients with non-metastatic bladder cancer diagnosed between 2004 and 2013 within the Surveillance, Epidemiology and End Results registries. Logistic regression analyses focused on grade and stage. Kaplan-Meier analyses assessed cancer-specific mortality rates in adenocarcinoma and urothelial carcinoma of the bladder...
November 22, 2016: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/27859268/heterogeneity-of-colorectal-cancer-risk-by-tumour-characteristics-large-prospective-study-of-uk-women
#16
Andrea Burón Pust, Rupert Alison, Roger Blanks, Kirstin Pirie, Kezia Gaitskell, Isobel Barnes, Toral Gathani, Gillian Reeves, Valerie Beral, Jane Green
Associations between behavioural and other personal factors and colorectal cancer risk have been reported to vary by tumour characteristics, but evidence is inconsistent. In a large UK-based prospective study we examined associations of 14 postulated risk factors with colorectal cancer risk overall, and across three anatomical sites and four morphological subtypes. Among 1.3 million women, 18,518 incident colorectal cancers were identified during 13.8 (SD 3.4) years follow-up via record linkage to national cancer registry data...
March 1, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27849427/generalized-high-bone-mineral-density-on-bone-density-scanning-a-case-of-gastric-carcinoma-with-bone-metastasis
#17
Pianpian Fan, Qin Wang, Chunyan Lu, Deicai Chen
Generalized high bone mineral density (BMD) on Dual-energy X-ray absorptiometry (DXA) scanning most commonly reflects metabolic bone disease. However, some malignancies could also stimulate the underlying processes. We reported that a 41-year-old female was referred for lumbago. She did not complain of any symptoms in the digestive system. DXA revealed high BMD in the lumbar vertebras. Marked increase in bone mass was observed in an X-ray of chest compared with one conducted 6 months previously. Additionally, an X-ray of the axial skeleton showed diffuse sclerotic change...
November 16, 2016: Postgraduate Medicine
https://www.readbyqxmd.com/read/27843583/nanostring-expression-profiling-identifies-candidate-biomarkers-of-rad001-response-in-metastatic-gastric-cancer
#18
Kakoli Das, Xiu Bin Chan, David Epstein, Bin Tean Teh, Kyoung-Mee Kim, Seung Tae Kim, Se Hoon Park, Won Ki Kang, Steve Rozen, Jeeyun Lee, Patrick Tan
BACKGROUND: Gene expression profiling has contributed greatly to cancer research. However, expression-driven biomarker discovery in metastatic gastric cancer (mGC) remains unclear. A gene expression profile predicting RAD001 response in refractory GC was explored in this study. METHODS: Total RNA isolated from 54 tumour specimens from patients with mGC, prior to RAD001 treatment, was analysed via the NanoString nCounter gene expression assay. This assay targeted 477 genes representing 10 different GC-related oncogenic signalling and molecular subtype-specific expression signatures...
2016: ESMO Open
https://www.readbyqxmd.com/read/27824770/microangiopathic-hemolytic-anemia-due-to-malignancy-in-pregnancy
#19
Sarah K Happe, Amanda C Zofkie, David B Nelson
BACKGROUND: Microangiopathic disorders during pregnancy remain a diagnostic challenge because these conditions often imitate more common obstetric diseases. CASE: A 31-year-old multigravid woman delivered at term with a postpartum course complicated by laboratory indices consistent with hemolysis, elevated liver enzymes, and low platelet count syndrome. After clinical recovery, she was readmitted 2 weeks after delivery with presumptive pyelonephritis. Persistent hemolysis and worsening thrombocytopenia suggested a diagnosis of thrombotic microangiopathy, which did not respond to plasma exchange...
December 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27798928/signet-ring-cells-and-efficacy-of-first-line-chemotherapy-in-advanced-gastric-or-oesogastric-junction-adenocarcinoma
#20
Nathalie Lemoine, Antoine Adenis, Olivier Bouche, Alain Duhamel, Alexandra Heurgue, Emmanuelle Leteurtre, Eric Amela, Julia Salleron, Mohamed Hebbar
AIM: To evaluate the efficacy of first-line palliative chemotherapy, regarding the presence of signet ring cells (SRC). PATIENTS AND METHODS: Retrospective analysis of consecutive patients with locally advanced or metastatic gastric or oesogastric junction adenocarcinoma who received first-line chemotherapy. Response to chemotherapy, progression-free survival (PFS) and overall survival (OS) were compared between SRC and non-SRC (NSRC) groups. RESULTS: Two hundred and three patients were treated, with 57 (28%) having SRC adenocarcinoma...
2016: Anticancer Research
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