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Signet ring cell adenocarcinoma

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https://www.readbyqxmd.com/read/29774226/metastatic-gastric-signet-ring-cell-carcinoma-mimicking-crohn-s-disease
#1
Michael W Winter, Amr Dokmak, Zachary Marnoy, Shweta Sinagare, Alexander N Levy
Signet-ring cell carcinoma (SRCC) is an adenocarcinoma characterized by mucin-producing cells and most commonly arises in the stomach. Colonic SRCC can share features of colitis, including long segments of concentric bowel wall thickening and ulcerated mucosa with regions of sparing. We describe a rare case of metastatic gastric SRCC mimicking Crohn's disease. Our patient underwent 2 colonoscopies, and biopsies revealed chronic active inflammation with no evidence of malignancy. The diagnosis of SRCC was only made after colectomy was performed for recurrent bowel obstruction...
2018: ACG Case Reports Journal
https://www.readbyqxmd.com/read/29747153/molecular-characterization-of-colorectal-signet-ring-cell-carcinoma-using-whole-exome-and-rna-sequencing
#2
Jae-Yong Nam, Bo Young Oh, Hye Kyung Hong, Joon Seol Bae, Tae Won Kim, Sang Yun Ha, Donghyun Park, Woo Yong Lee, Hee Cheol Kim, Seong Hyeon Yun, Yoon Ah Park, Je-Gun Joung, Woong-Yang Park, Yong Beom Cho
BACKGROUND: Signet-ring cell carcinoma (SRCC) is a very rare subtype of colorectal adenocarcinoma (COAD) with a poor clinical prognosis. Although understanding key mechanisms of tumor progression in SRCCs is critical for precise treatment, a comprehensive view of genomic alterations is lacking. MATERIALS AND METHODS: We performed whole-exome sequencing of tumors and matched normal blood as well as RNA sequencing of tumors and matched normal colonic tissues from five patients with SRCC...
May 7, 2018: Translational Oncology
https://www.readbyqxmd.com/read/29744885/morphologic-mimicry-acantholytic-squamous-cell-carcinoma-in-nondermal-locations-a-literature-review
#3
REVIEW
Mustafa Mohammad, Rebecca Wilcox
Acantholytic squamous cell carcinoma (acantholytic SCC) is a variant of SCC in which acantholysis develops owing to the loss of desmosomal adhesion proteins. This loss of cell-cell adhesion leads to morphologic changes that have the potential to mimic other tumor types, such as angiosarcoma or signet ring cell adenocarcinoma. Acantholytic SCC characteristically occurs in sun-exposed skin of elderly patients; however, it can occur in nondermal locations. We present a review of the literature describing cases of nondermal acantholytic SCC...
May 9, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29729716/diffuse-type-gastric-mucinous-and-signet-ring-cell-adenocarcinoma-in-a-captive-california-king-snake-lampropeltis-getula-californiae
#4
C-S Hsueh, W-T Li, C-R Jeng, V F Pang, H-W Chang
An adult female California king snake (Lampropeltis getula californiae) housed in Taipei Zoo was presented with a 2-week history of anorexia, fatigue and abdominal swelling. Exploratory laparotomy revealed a gastric mass with two circular perforations and multiple mottled white to beige protuberances along the mucosal surface. Histologically, the gastric mass showed an invasive, transmural growth of epithelial cells arranged in nests, lobules, acini and sheets in the mucosa and submucosa that progressively transformed into signet ring cells in the muscularis externa and subserosa...
April 2018: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/29719284/characterization-of-helicobacter-pylori-na%C3%A3-ve-early-gastric-cancers
#5
Akihiro Yamada, Mitsuru Kaise, Naoko Inoshita, Takahito Toba, Kosuke Nomura, Yasutaka Kuribayashi, Satoshi Yamashita, Tsukasa Furuhata, Daisuke Kikuchi, Akira Matsui, Toshifumi Mitani, Osamu Ogawa, Toshiro Iizuka, Shu Hoteya
AIM: Helicobacter pylori-naïve gastric cancers(GCs) have not been well documented. We aimed to characterize early H. pylori-naïve GCs. SUBJECTS AND METHODS: Of 666 patients with GC resected by endoscopic submucosal dissection, H. pylori-naïve patients were extracted according to the definition: no H. pylori eradication history, negative for serum H. pylori-antibody and current H. pylori-infection tests, and no gastric atrophy by pepsinogen (PG) test, endoscopy, and histology...
May 2, 2018: Digestion
https://www.readbyqxmd.com/read/29694966/gastric-adenocarcinomas-in-central-tunisia-evolution-specificities-through-two-decades-and-relation-with-helicobacter-pylori
#6
Mohamed Amine Elghali, Amine Gouader, Rym Bouriga, Mohamed Mahjoub, Mohamed Salah Jarrar, Sonia Ziadi, Moncef Mokni, Fahmi Hamila, Rached Ltaeif
INTRODUCTION: In developed countries, authors have reported variations over time in the seat and histological type of gastric adenocarcinomas, which were explained by Helicobacter pylori infection (HPI) incidence changes. In North-African countries and the Arabic world, epidemiological changes in gastric adenocarcinomas are still unknown. Our study aims to explore and to describe those changes in central Tunisia. MATERIALS AND METHODS: This is a retrospective observational and descriptive study including 876 cases based on the National Central Tunisian Register of Cancers over a period of 21 years...
April 25, 2018: Oncology
https://www.readbyqxmd.com/read/29683821/urothelial-carcinoma-in-situ-of-the-bladder-with-glandular-differentiation-report-of-92-cases
#7
Zhiming Yang, Jonathan I Epstein
Urothelial carcinoma in situ (CIS) of the bladder with glandular differentiation (CIS-GL) is rare with some showing an association with small cell carcinoma. There is a paucity of data on whether CIS-GL diagnosed in the absence of invasive carcinoma is associated with an increased risk of developing small cell carcinoma of the bladder. Twenty-seven cases of CIS-GL were identified from the consult files of one of the authors from 2008 to 2015 without prior or coexisting invasive carcinoma at the time of diagnosis...
April 20, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29658333/mucinous-breast-carcinoma-with-tall-columnar-cells
#8
N Tsoukalas, M Kiakou, M Tolia, I D Kostakis, M Galanopoulos, G Nakos, D Tryfonopoulos, G Kyrgias, G Koumakis
Mucinous carcinoma of the breast represents 1%-4% of all breast cancers. The World Health Organization classification divides this type of tumour into three different subtypes: mucinous carcinoma, mucinous carcinoma with tall columnar cells (mucinous cystadenocarcinoma and columnar cell mucinous carcinoma) and signet ring cell carcinoma. A 74-year-old woman presented a tumour with inflammatory features in the upper outer quadrant of her left breast, 7 cm in diameter. The core biopsy showed infiltrating ductal carcinoma of no specific type...
April 16, 2018: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/29572575/metastatic-colonic-and-gastric-polyps-from-breast-cancer-resembling-hyperplastic-polyps
#9
Yoshiya Horimoto, Tetsuro Hirashima, Atsushi Arakawa, Hiroyoshi Miura, Mitsue Saito
Breast cancer metastasis to the gastrointestinal tract is relatively rare and is generally found when patients complain of symptoms such as gastrointestinal obstruction. Herein, we report a case with metastatic colonic and gastric lesions from breast cancer, with the formation of mucosal polyps which resembled typical hyperplastic polyps.A 47-year-old woman underwent curable surgery for breast cancer and received standard systemic treatments. Her primary tumor was composed of a mix of invasive lobular and ductal carcinomas...
March 23, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29569125/preoperative-nomogram-to-risk-stratify-patients-for-the-benefit-of-trimodality-therapy-in-esophageal-adenocarcinoma
#10
Lucas Goense, Peter S N van Rossum, Mian Xi, Dipen M Maru, Brett W Carter, Gert J Meijer, Linus Ho, Richard van Hillegersberg, Wayne L Hofstetter, Steven H Lin
PURPOSE: To develop a nomogram that estimates 1-year recurrence-free survival (RFS) after trimodality therapy for esophageal adenocarcinoma and to assess the overall survival (OS) benefit of esophagectomy after chemoradiotherapy (CRT) on the basis of 1-year recurrence risk. METHODS: In total, 568 consecutive patients with potentially resectable esophageal adenocarcinoma who underwent CRT were included for analysis, including 373 patients who underwent esophagectomy after CRT (trimodality therapy), and 195 who did not undergo surgery (bimodality therapy)...
March 22, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29559034/development-of-bone-metastasis-secondary-to-appendiceal-adenocarcinoma-with-signet-ring-cells
#11
Amanda N Goldin, Ashish Mittal, Anna A Kulidjian
No abstract text is available yet for this article.
March 1, 2018: American Surgeon
https://www.readbyqxmd.com/read/29533002/differences-in-clinicopathological-characteristics-and-computed-tomography-findings-between-signet-ring-cell-carcinoma-and-nonsignet-ring-cell-carcinoma-in-early-and-advanced-gastric-cancer
#12
Jian Chen, Rong Cai, Gang Ren, Jianxi Zhao, Huali Li, Chen Guo, Wenguang He, Xiangru Wu, Wenjie Zhang
Signet ring cell carcinoma (SRC) of the stomach is a histological type based on microscopic characteristics. SRC's clinicopathological characteristics and prognosis are still controversial. Our study is to describe the clinicopathological features and multidetector computed tomography (MDCT) findings of patients with SRC of the stomach in comparison with nonsignet ring cell adenocarcinoma (NSRC). We retrospectively analyzed data from 241 patients who had undergone curative gastrectomy, including 62 SRC and 179 NSRC...
April 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29533001/comparison-of-survival-between-right-sided-and-left-sided-colon-cancer-in-different-situations
#13
Miao-Zhen Qiu, Wen-Tao Pan, Jun-Zhong Lin, Zi-Xian Wang, Zhi-Zhong Pan, Feng-Hua Wang, Da-Jun Yang, Rui-Hua Xu
Mountain of studies has showed that right-sided colon cancer (RSCC) and left-sided colon cancer (LSCC) have different clinical presentation and biologic features and should be considered as two distinct disease entities. The survival difference between RSCC and LSCC remains controversial. Using Surveillance, Epidemiology, and End Results (SEER) database, we identified colon adenocarcinoma patients from 2004 to 2013. The 5-year cause-specific survival (CSS) was our primary endpoint. All statistical analyses were performed using the Intercooled Stata 13...
April 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29524972/sociodemographic-and-survival-disparities-for-histologic-variants-of-bladder-cancer
#14
Joshua S Jue, Tulay Koru-Sengul, Kevin J Moore, Feng Miao, Mahmoud Alameddine, Bruno Nahar, Sanoj Punnen, Dipen J Parekh, Chad R Ritch, Mark L Gonzalgo
INTRODUCTION: To investigate the impact of perioperative factors on overall survival among patients with histologic variants of bladder cancer treated with radical cystectomy. MATERIALS AND METHODS: The National Cancer Data Base was utilized to identify patients diagnosed with muscle-invasive bladder cancer (cT2-4, N0, M0) from 2004-2013. Variant histology bladder cancers (non-mucinous adenocarcinoma, mucinous/signet ring adenocarcinoma, micropapillary urothelial carcinoma, small cell carcinoma, and squamous cell carcinoma) were compared to urothelial carcinoma with respect to overall survival...
February 2018: Canadian Journal of Urology
https://www.readbyqxmd.com/read/29511550/endoscopic-submucosal-dissection-of-gastric-superficial-neoplastic-lesions-a-single-western-center-experience
#15
Lucio Petruzziello, Mariachiara Campanale, Cristiano Spada, Riccardo Ricci, Cesare Hassan, Gaia Gullo, Guido Costamagna
Background: Endoscopic submucosal dissection (ESD) allows "en bloc" resection of superficial gastric lesions. Objective: The aim of this study is to report "en bloc" resection rate, procedure results, post resection features, analysis of complications, and relapses at mid-long term follow-up on an Italian center case series of patients with superficial gastric neoplastic lesions treated with ESD. Methods: This is a retrospective evaluation of a prospectively collected series of patients diagnosed with gastric superficial lesions who underwent ESD between November 2007 and May 2015...
March 2018: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29492918/-surgical-treatment-and-prognosis-of-borrmann-type-iiii-gastric-cancer-involving-the-whole-stomach
#16
Ruizeng Dong, Zewei Zhang, Yiming Zhou, Yonghong Hua, Jianmin Guo
OBJECTIVE: To explore the surgical treatment and prognosis of Borrmann type IIII( gastric cancer involving the whole stomach. METHODS: Clinicopathological characteristics and survival data of 223 patients with Borrmann type IIII( gastric cancer involving the whole stomach (defined as the tumor infiltrating 3 regions of the stomach) receiving surgical treatment at the Department of Abdominal Surgery of Zhejiang Cancer Hospital between January 2002 and December 2015 were analyzed retrospectively...
February 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29484053/mucinous-carcinoma-of-the-gallbladder-with-signet-ring-cells
#17
Takeshi Fukuda, Yoshihiro Sakimoto, Kenichi Narita, Mitsuko Ariizumi, Yoshio Aizawa, Kunihiko Fukuda
Most gallbladder carcinomas are adenocarcinomas, of which mucinous carcinoma (MC) is a rare pathologic subtype. Signet ring cells are seldom found in MCs. We report an extremely rare case of gallbladder MC with signet ring cells. This is the first radiological case report about this rare type of histologic entity with detailed discussion of imaging findings in the English literature. In addition to the features of MC, linitis plastica-like invasion, which is the key feature of signet ring cells, was confirmed by both imaging and histopathologic analysis...
December 2017: Radiology Case Reports
https://www.readbyqxmd.com/read/29457051/signet-ring-cell-carcinoma-ileal-crohn-disease-or-both-a-case-of-diagnostic-challenge
#18
Joana R Carvalho, Joana Tavares, Inês Goulart, Paula Moura Dos Santos, Emília Vitorino, Cristina Ferreira, Fátima Serejo, José Velosa
Signet ring cell carcinoma is a rare form of adenocarcinoma that predominantly affects the stomach. Signet ring cell carcinoma originated from the ileum is extremely rare and the prognosis is poor. We present a case of small bowel obstruction with features suggesting Crohn disease of the ileum. The symptoms were chronic diarrhea and abdominal pain with a family history of inflammatory bowel disease. The patient underwent surgery and histopathology revealed both aspects of signet ring cell carcinoma and Crohn disease of the ileum...
January 2018: GE Portuguese Journal of Gastroenterology
https://www.readbyqxmd.com/read/29434119/a-case-of-helicobacter-pylori-negative-advanced-gastric-cancer-with-massive-eosinophilia
#19
Atsushi Takagi, Hideki Ozawa, Masayuki Oki, Hidetaka Yanagi, Kazuhito Nabeshima, Naoto Nakamura
The incidence of Helicobacter pylori-negative gastric cancer is very low. A 60-year-old man was referred to Tokai University Hospital from a local clinic because of eosinophilia. The laboratory data revealed prominent eosinophilia, with a white blood cell count of 7,900/μl and increased eosinophil granulocyte level of 1,659/μl. After an examination for secondary eosinophilia, esophagogastroduodenoscopy showed an enlarged gastric fold in the corpus, suggesting type 4 gastric cancer. Repeated EGD and a re-biopsy demonstrated poorly differentiated adenocarcinoma and signet ring cell carcinoma...
February 9, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29425880/protoporphyrinogen-oxidase-is-involved-in-the-fluorescence-intensity-of-5-aminolevulinic-acid-mediated-laser-based-photodynamic-endoscopic-diagnosis-for-early-gastric-cancer
#20
Hiroki Kurumi, Tsutomu Kanda, Koichiro Kawaguchi, Kazuo Yashima, Hiroki Koda, Kumi Ogihara, Kayoko Matsushima, Kazuhiko Nakao, Hiroaki Saito, Yoshiyuki Fujiwara, Mitsuhiko Osaki, Futoshi Okada, Hajime Isomoto
BACKGROUND/AIM: Laser-based photodynamic endoscopic diagnosis (LPDED) is a type of endoscopic diagnosis that uses the fluorescence caused by the photochemical reaction that occurs when a fluorescent substance is irradiated by a light of a specific wavelength. Although 5-aminolevulinic acid (5-ALA) can detect early gastric cancer (EGC) during LPDED, there is an unresolved issue of the differences in fluorescence intensity among histopathological types of gastric cancer. Thus, the aim of the present study was to assess whether protoporphyrinogen oxidase (PPOX), involved in the activation of protoporphyrin IX, can affect the fluorescence intensity in EGC...
February 6, 2018: Photodiagnosis and Photodynamic Therapy
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