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Gastric dysplasia

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https://www.readbyqxmd.com/read/28728313/the-effect-of-helicobacter-pylori-eradication-on-the-metachronous-neoplasm-after-endoscopic-resection-for-gastric-dysplasia
#1
Ji Hyun Song, Sun Young Yang, Joo Hyun Lim, Ji Min Choi, Sang Gyun Kim
Background/Aims: Helicobacter pylori (Hp) infection is an important risk factor for gastric carcinogenesis. Although several studies have investigated the effect of Hp eradication on the development of metachronous neoplasm after endoscopic resection of the gastric dysplasia, the evidence is still insufficient to make a clear conclusion. The aims of this study was to evaluate the risk factors for the development of metachronous neoplasm after endoscopic resection of gastric dysplasia and to investigate the effect of Hp eradication...
July 25, 2017: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/28725964/toward-early-detection-of-helicobacter-pylori-associated-gastric-cancer
#2
Rachel Walker, Jan Poleszczuk, Jaime Mejia, Jae K Lee, Jose M Pimiento, Mokenge Malafa, Anna R Giuliano, Heiko Enderling, Domenico Coppola
BACKGROUND: Gastric cancer is typically diagnosed at a late stage, leading to poor prognoses. Helicobacter pylori is responsible for 70% of gastric cancers globally, and patients with this bacterial infection often present with early stages of the carcinogenic pathway such as inflammation or gastritis. Although many patients continue to progress to advanced-stage disease after antibacterial treatment, there are no follow-up screening protocols for patients with a history of H. pylori...
July 19, 2017: Gastric Cancer
https://www.readbyqxmd.com/read/28725300/epstein-barr-virus-ebv-associated-epithelial-and-non-epithelial-lesions-of-the-oral-cavity
#3
REVIEW
Kentaro Kikuchi, Harumi Inoue, Yuji Miyazaki, Fumio Ide, Masaru Kojima, Kaoru Kusama
Epstein-Barr virus (EBV) is known to be associated with the development of malignant lymphoma and lymphoproliferative disorders (LPDs) in immunocompromised patients. EBV, a B-lymphotropic gamma-herpesvirus, causes infectious mononucleosis and oral hairy leukoplakia, as well as various pathological types of lymphoid malignancy. Furthermore, EBV is associated with epithelial malignancies such as nasopharyngeal carcinoma (NPC), salivary gland tumor, gastric carcinoma and breast carcinoma. In terms of oral disease, there have been several reports of EBV-related oral squamous cell carcinoma (OSCC) worldwide...
August 2017: Japanese Dental Science Review
https://www.readbyqxmd.com/read/28723278/a-case-of-cannabinoid-hyperemesis-syndrome-with-heliobacter-pylori-and-pre-eclampsia-during-pregnancy
#4
Madeline Manning Meurer, Kalyan Chakrala, Dinesh Gowda, Charles Burns, Randall Kelly, Natalia Schlabritz-Loutsevitch
The condition termed cannabinoid hyperemesis syndrome (CHS) was characterized a decade ago by Allen et al. and includes cyclic episodes of nausea and vomiting and the learned behavior of hot bathing in individuals with chronic cannabis abuse. During pregnancy, the differential diagnosis of this syndrome is challenging since it can be masked by typical symptoms of early pregnancy or by hyperemesis gravidarum, a complication of early pregnancy associated with excessive nausea and vomiting. We herein describe the case of a 21-year-old primigravida patient diagnosed with hyperemesis gravidarum at 6 weeks of gestation and with pre-eclampsia at 35 weeks...
July 19, 2017: Substance Abuse
https://www.readbyqxmd.com/read/28706423/risk-factors-for-metachronous-gastric-carcinoma-development-after-endoscopic-resection-of-gastric-dysplasia-retrospective-single-center-study
#5
Hee Seok Moon, Gee Young Yun, Ju Seok Kim, Hyuk Soo Eun, Sun Hyung Kang, Jae Kyu Sung, Hyun Yong Jeong, Kyu-Sang Song
AIM: To determine the gastric adenocarcinoma (GAC) occurrence rate and related factors, we evaluated the follow-up results of patients confirmed to have gastric dysplasia after endoscopic resection (ER). METHODS: We retrospectively analyzed the medical records, endoscopic examination records, endoscopic procedure records, and histological records of 667 cases from 641 patients who were followed-up for at least 12 mo, from among 1273 patients who were conformed to have gastric dysplasia after Endoscopic mucosal resection (EMR) or endoscopic submucosal dissection (ESD) of gastric mucosal lesions between January 2007 and August 2013 at the Chungnam National University Hospital...
June 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28705771/different-frequencies-of-porphyromonas-gingivalis-infection-in-cancers-of-the-upper-digestive-tract
#6
Xiang Yuan, Yiwen Liu, Jinyu Kong, Bianli Gu, Yijun Qi, Xinshuai Wang, Man Sun, Pan Chen, Wei Sun, Huizhi Wang, Fuyou Zhou, Shegan Gao
The high incidence rate of multiple carcinomas in the upper digestive tract is often explained in terms of involvement of the same underlying risk factors. It has been reported that the oral bacterium Streptococcus anginosus is associated with esophageal, gastric, and pharyngeal cancers. We previously reported occurrence of Porphyromonas gingivalis (P. gingivalis) DNA in esophagus cancer. In this study, the presence of P. gingivalis in specimens of various types of cancer from the upper digestive tract was investigated...
July 11, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28705420/is-it-necessary-to-perform-full-pathologic-review-of-all-gastric-remnants-following-sleeve-gastrectomy
#7
S K Hansen, B J Pottorf, H W Hollis, J L Rogers, F A Husain
BACKGROUND: This study attempts to determine if enough pathological abnormalities in gastric remnants from sleeve gastrectomy exist to warrant full pathologic evaluation in all remnants. METHODS: Data was collected on patients undergoing sleeve gastrectomy between 08/01/2011 and 06/30/2014. Significant abnormalities were classified as any pathology that might require follow-up or treatment beyond standard follow-up. Age, comorbidities, gender, and Helicobacter pylori titers were analyzed and compared with pathology specimens using 95% confidence intervals and Phi contingency coefficients...
July 1, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28700998/a-decrease-of-histone-deacetylase-6-expression-caused-by-helicobacter-pylori-infection-is-associated-with-oncogenic-transformation-in-gastric-cancer
#8
Qing He, Guoqiang Li, Xin Wang, Shubin Wang, Jiang Hu, Lang Yang, Yuqi He, Yuanming Pan, Dedong Yu, Yun Wu
BACKGROUND: Histone deacetylase 6 (HDAC6) plays a role in the progression of many tumors. However, the relationship between the level of HDAC6 expression and gastric tumorigenesis is still unclear. Here, we illustrate the potential correlation between Helicobacter pylori (HP) infection and the variation of HDAC6 expression in different gastric lesions, as well as the clinical significance of HDAC6 expression in gastric cancer (GC) patients. MATERIALS AND METHODS: Between 2011 and 2016, 364 patients with different types of gastric lesions were enrolled in Baotou City Central Hospital...
July 13, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28694663/inhibition-of-n-methyl-n-nitrosourea-induced-gastric-tumorigenesis-by-liuwei-dihuang-pill-in-db-db-mice
#9
Shan Zhuang, Yong-Mei Jian, Yong-Ning Sun
AIM: To investigate the inhibitory effect of Liuwei Dihuang Pill (LDP) on gastric tumorigenesis induced by N-methyl-N-nitrosourea (MNU) in diabetic mice. METHODS: Four-week-old mice were divided into four groups: A, 12 db/m mice treated with MNU and saline, as the non-diabetic control; B, 12 db/db mice treated with MNU and saline, as the diabetic control; C, 12 db/db mice treated with MNU and metformin, as the positive control; and D, 12 db/db mice treated with MNU and LDP...
June 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28668512/h-pylori-infection-increases-gastric-mucosal-cox2-and-mtor-expression-in-chronic-gastritis-implications-for-cancer-progression
#10
Dalia M Badary, Mohammed Zakaria Ali Abu Rahma, Ahmed M Ashmawy, Mohamed Z Hafez
BACKGROUND: Helicobacter Pylori is a Gram-negative bacterium that infects the human stomach and plays an important role in the pathogenesis of chronic gastritis. H. pylori associated chronic gastritis affects various molecular markers related to gastric cancer development. The aim of this study to assess the effect of H. pylori infection on gastric mucosa and to explore its role in gastric carcinogenesis via COX2 and mTOR mucosal expression. MATERIALS AND METHODS: This study comprised archival blocks from 60 dyspeptic patients who underwent gastric endoscopic biopsies for histopathological examination...
June 17, 2017: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/28664941/small-bowel-carcinomas-in-celiac-or-crohn-s-disease-distinctive-histophenotypic-molecular-and-histogenetic-patterns
#11
Alessandro Vanoli, Antonio Di Sabatino, Michele Martino, Catherine Klersy, Federica Grillo, Claudia Mescoli, Gabriella Nesi, Umberto Volta, Daniele Fornino, Ombretta Luinetti, Paolo Fociani, Vincenzo Villanacci, Francesco P D'Armiento, Renato Cannizzaro, Giovanni Latella, Carolina Ciacci, Livia Biancone, Marco Paulli, Fausto Sessa, Massimo Rugge, Roberto Fiocca, Gino R Corazza, Enrico Solcia
Non-familial small bowel carcinomas are relatively rare and have a poor prognosis. Two small bowel carcinoma subsets may arise in distinct immune-inflammatory diseases (celiac disease and Crohn's disease) and have been recently suggested to differ in prognosis, celiac disease-associated carcinoma cases showing a better outcome, possibly due to their higher DNA microsatellite instability and tumor-infiltrating T lymphocytes. In this study, we investigated the histological structure (glandular vs diffuse/poorly cohesive, mixed or solid), cell phenotype (intestinal vs gastric/pancreatobiliary duct type) and Wnt signaling activation (β-catenin and/or SOX-9 nuclear expression) in a series of 26 celiac disease-associated small bowel carcinoma, 25 Crohn's disease-associated small bowel carcinoma and 25 sporadic small bowel carcinoma cases, searching for new prognostic parameters...
June 30, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28656881/low-expression-of-hsa_circ_0006633-in-human-gastric-cancer-and-its-clinical-significances
#12
Rongdan Lu, Yongfu Shao, Guoliang Ye, Bingxiu Xiao, Junming Guo
Circular RNAs are new type of endogenous RNAs, which play an important role in the regulation of gene expression and indicate a great capacity in clinical diagnosis and treatments of diseases. However, the role of circular RNAs in gastric cancer remains unknown. In this study, we chose hsa_circ_0006633 as the target circular RNA and measured its levels in human gastric cancer tissues, plasma, and gastric cell lines by real-time quantitative reverse transcription polymerase chain reaction. Hsa_circ_0006633 levels at multiple stages of gastric tumorigenesis were then explored, and its relationships with clinicopathological features were analyzed as well...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28655977/a-systematic-review-and-meta-analysis-of-the-role-of-helicobacter-pylori-eradication-in-preventing-gastric-cancer
#13
Theodore Rokkas, Androniki Rokka, Piero Portincasa
BACKGROUND: Increasing evidence has suggested that Helicobacter pylori (H. pylori) eradication might prevent the development of gastric cancer (GC). This systematic review and meta-analysis aimed to better explore the role of H. pylori eradication in preventing GC, with particular reference to patients with precancerous lesions at baseline histology. METHODS: Searches for human studies were performed through October 2016 and risk ratios (RRs), were obtained. Heterogeneity between studies was estimated using the Cochran Q test and I(2) values, whereas the possibility of publication bias was estimated with funnel plots...
2017: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/28616732/erratum-to-early-gastric-adenocarcinoma-arising-within-foveolar-type-dysplasia-in-a-patient-with-muir-torre-variant-lynch-syndrome
#14
Tristan F P McKnight, Amy E Noffsinger, Kara K Landry, Ovais Ahmed, Rebecca Wilcox
No abstract text is available yet for this article.
June 15, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28611525/clinical-significance-of-expression-of-proliferating-cell-nuclear-antigen-and-e-cadherin-in-gastric-carcinoma
#15
Lin Hu, Hong-Lang Li, Wei-Feng Li, Jun-Min Chen, Jian-Tao Yang, Jun-Jing Gu, Lin Xin
AIM: to investigate the expression of proliferating cell nuclear antigen (PCNA) and E-cadherin in gastric carcinoma and to analyze their clinical significance. METHODS: A total of 146 patients were selected for this study, including 38 patients with intestinal metaplasia, 42 with dysplasia, and 66 with primary gastric cancer. In addition, 40 patients with normal gastric tissues were selected as controls. The expression of PCNA and E-cadherin was detected by immunohistochemistry...
May 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28600361/coding-of-barrett-s-oesophagus-with-high-grade-dysplasia-in-national-administrative-databases-a-population-based-cohort-study
#16
Georgina Chadwick, Mira Varagunam, Christian Brand, Stuart A Riley, Nick Maynard, Tom Crosby, Julie Michalowski, David A Cromwell
OBJECTIVES: The International Classification of Diseases 10th Revision (ICD-10) system used in the English hospital administrative database (Hospital Episode Statistics (HES)) does not contain a specific code for oesophageal high-grade dysplasia (HGD). The aim of this paper was to examine how patients with HGD were coded in HES and whether it was done consistently. SETTING: National population-based cohort study of patients with newly diagnosed with HGD in England...
June 9, 2017: BMJ Open
https://www.readbyqxmd.com/read/28593183/columnar-metaplasia-in-three-types-of-surgical-mouse-models-of-esophageal-reflux
#17
Fabio Terabe, Susumu Aikou, Junko Aida, Nobutake Yamamichi, Michio Kaminishi, Kaiyo Takubo, Yasuyuki Seto, Sachiyo Nomura
BACKGROUND AND AIMS: Esophageal adenocarcinoma develops in the setting of gastroesophageal reflux and columnar metaplasia in distal esophagus. Columnar metaplasia arising in gastroesophageal reflux models has developed in rat; however, gastroesophageal reflux models in mice have not been well-characterized. METHODS: One hundred thirty-five C57Bl/6J mice aged 8 weeks old were divided into the following operations: esophagogastrojejunostomy (side-to-side) (EGJ), esophageal separation and esophagojejunostomy (end-to-side) (EJ), and EJ and gastrectomy (end-to-side) (EJ/TG)...
July 2017: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28584893/development-of-novel-monoclonal-antibodies-for-evaluation-of-transmembrane-prostate-androgen-induced-protein-1-tmepai-expression-patterns-in-gastric-cancer
#18
Mikhail S Karbyshev, Evgeniya S Grigoryeva, Viktor V Volkomorov, Elisabeth Kremmer, Alexander Huber, Irina V Mitrofanova, Evgeniya V Kaigorodova, Marina V Zavyalova, Julia G Kzhyshkowska, Nadezda V Cherdyntseva, Evgeny L Choynzonov
Transmembrane prostate androgen-induced protein 1 (TMEPAI) is a single-span membrane protein, functionally involved in transforming growth factor beta signaling pathway. The particular protein presented in cells in three isoforms, which differs in the length of the soluble N-terminal extracellular domain, making it challenging for the immunochemical recognition. By using quantitative real-time polymerase chain reaction, we identified significant upregulation of PMEPA1 gene expression in malignant tissues of patients with gastric adenocarcinoma...
June 5, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28573231/moxibustion-alleviates-gastric-precancerous-lesions-in-rats-by-promoting-cell-apoptosis-and-inhibiting-proliferation-related-oncogenes
#19
Li Peng, Yu-Feng Xie, Chen-Guang Wang, Huan-Gan Wu, Mi Liu, Ya-Dong Wang, Fu-Qiang Ma, Xiao-Rong Chang, Zong-Bao Yang
BACKGROUND: It is well known that gastric mucosa dysplasia and intestinal metaplasia are gastric precancerous lesions (GPL). Moxibustion treatment of Liangmen (ST21) and Zusanli (ST36) alleviated the inflammatory response and dysplasia of gastric mucosa in our previous study. The purpose of this study was to further examine the underlying mechanism of moxibustion treatment of ST21 and ST36 on GPL. MATERIALS AND METHODS: Sixty SD rats were divided into five groups and rats with GPL were treated with either moxibustion (ST), moxibustion (Sham), or vitacoenzyme...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28560293/isthmus-stem-cells-are-the-origins-of-metaplasia-in-the-gastric-corpus
#20
Yoku Hayakawa, James G Fox, Timothy C Wang
The acquisition of genetic/epigenetic mutations in long-lived gastrointestinal stem cells leads to the development of cancer, as well as precancerous lesions such as metaplasia and dysplasia. In the proximal stomach corpus, this model of progression from stem cells has been supported by studies in mice and human beings, showing abundant proliferation in the isthmus and clonal expansion of mutated cells from the stem cell region. An alternative theory proposes that gastric metaplasia arises from mature differentiated chief cells...
July 2017: Cellular and Molecular Gastroenterology and Hepatology
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