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Gastric dysplasia

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https://www.readbyqxmd.com/read/27895502/human-papillomavirus-as-a-potential-risk-factor-for-gastric-cancer-a-meta-analysis-of-1-917-cases
#1
Zhi-Ming Zeng, Fei-Fei Luo, Lin-Xia Zou, Rong-Quan He, Deng-Hua Pan, Xin Chen, Ting-Ting Xie, Yuan-Qing Li, Zhi-Gang Peng, Gang Chen
BACKGROUND: Human papillomaviruses (HPVs) are causally associated with the tumorigenesis of several classes of cancers. However, the prevalence of HPV in gastric cancer (GC) has not yet been systematically reviewed. Hence, a meta-analysis was conducted to estimate the HPV prevalence in patients with GC, and its potential etiologic significance was assessed. METHODS: The pooled HPV prevalence and 95% confidence intervals (CIs) were estimated among all GC patients...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27886403/rapid-test-for-lung-maturity-based-on-spectroscopy-of-gastric-aspirate-predicted-respiratory-distress-syndrome-with-high-sensitivity
#2
Henrik Verder, Christian Heiring, Howard Clark, David Sweet, Torben E Jessen, Finn Ebbesen, Lars J Björklund, Bengt Andreasson, Lars Bender, Aksel Bertelsen, Marianne Dahl, Christian Eschen, Jesper Fenger-Grøn, Stine F Hoffmann, Agnar Höskuldsson, Maria Bruusgaard-Mouritsen, Fredrik Lundberg, Anthony D Postle, Peter Schousboe, Peter Schmidt, Hristo Stanchev, Lars Sørensen
AIM: Respiratory distress syndrome (RDS) is a major cause of mortality and morbidity in premature infants. By the time symptoms appear it may already be too late to prevent a severe course, with bronchopulmonary dysplasia or mortality. We aimed to develop a rapid test of lung maturity for targeting surfactant supplementation. METHODS: Concentrations of the most surface-active lung phospholipid dipalmitoylphosphatidylcholine and sphingomyelin in gastric aspirates from premature infants were measured by mass spectrometry and expressed as the lecithin/sphingomyelin ratio (L/S)...
November 25, 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27858920/clinical-risk-assessment-for-gastric-cancer-in-asymptomatic-population-after-a-health-check-up-an-individualized-consideration-of-the-risk-factors
#3
Yoo Mi Park, Jie-Hyun Kim, Su Jung Baik, Jae Jun Park, Young Hoon Youn, Hyojin Park
For the prevention of gastric cancer, the detection of risk factors associated with precancerous conditions may be more informative. The aim of this study was to identify the risk factors of gastric cancer, including precancerous conditions: atrophic gastritis (AG), intestinal metaplasia (IM), and dysplasia.The clinical and endoscopic findings of 60,261 adults who underwent gastroduodenoscopy as part of a health check-up were reviewed retrospectively. Subgroup analysis was conducted according to age, sex, cancer stage, and histology based on Lauren classification...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27833394/two-cases-of-adenocarcinoma-occurring-in-sporadic-fundic-gland-polyps-observed-by-magnifying-endoscopy-with-narrow-band-imaging
#4
Kazumi Togo, Tetsuya Ueo, Hirotoshi Yonemasu, Hideho Honda, Tetsuya Ishida, Hiroshi Tanabe, Kenshi Yao, Akinori Iwashita, Kazunari Murakami
Gastric fundic gland polyps (FGPs) are common non-adenomatous gastric polyps arising from normal fundic mucosa without Helicobacter pylori (H. pylori) infection. Although systemic FGPs associated with familial adenomatous polyposis (FAP) often have dysplasia, there are few reports of dysplasia occurring in sporadic FGPs, especially when detected by magnifying endoscopy with narrow band imaging (ME-NBI). We experienced two cases of adenocarcinoma occurring in sporadic FGPs, and their ME-NBI findings were very useful for differentiating FGP with cancer from non-dysplastic FGP...
October 28, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27832356/risk-factors-for-intestinal-metaplasia-in-a-southeastern-chinese-population-an-analysis-of-28-745-cases
#5
Jian-Xia Jiang, Qing Liu, Bing Zhao, Hai-Han Zhang, Huai-Ming Sang, Soyfoo-Muhammad Djaleel, Guo-Xin Zhang, Shun-Fu Xu
PURPOSE: To identify risk factors for intestinal metaplasia in a southeastern Chinese population. METHODS: Subjects who underwent upper GI endoscopy and endoscopic biopsy in the First Affiliated Hospital of Nanjing Medical University from 2008 to 2013 were included into this study. Various demographic, geographic, clinical and pathological data were analyzed separately to identify risk factors for intestinal metaplasia. RESULTS: The incidence of intestinal metaplasia differed significantly in 17 municipal areas ranging from 16...
November 10, 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27822683/clinical-outcomes-of-endoscopic-submucosa-dissection-for-high-grade-dysplasia-from-endoscopic-forceps-biopsy
#6
Dae Gon Ryu, Cheol Woong Choi, Dae Hwan Kang, Hyung Wook Kim, Su Bum Park, Su Jin Kim, Hyeong Seok Nam
BACKGROUND AND STUDY AIMS: Although the Vienna Classification recommends endoscopic resection for gastric high-grade dysplasia (HGD), many resected lesions are diagnosed as gastric cancer after endoscopic resection. This study aims to evaluate the clinical outcomes of gastric HGD identified by endoscopic forceps biopsy (EFB) after endoscopic submucosal dissection (ESD) and factors associated with discrepant results. PATIENTS AND METHODS: From December 2008 to July 2015, a total of 427 lesions diagnosed as initial HGD by EFB were enrolled...
November 7, 2016: Gastric Cancer
https://www.readbyqxmd.com/read/27816419/ectopic-gastric-and-intestinal-phenotypes-neuroendocrine-cell-differentiation-and-sox2-expression-correlated-with-early-tumor-progression-in-colorectal-laterally-spreading-tumors
#7
Takahito Katano, Tsutomu Mizoshita, Hironobu Tsukamoto, Hirotada Nishie, Yusuke Inagaki, Noriyuki Hayashi, Satoshi Nomura, Keiji Ozeki, Yasuyuki Okamoto, Takaya Shimura, Yoshinori Mori, Eiji Kubota, Satoshi Tanida, Hiromi Kataoka, Toshiya Kuno, Satoru Takahashi, Takashi Joh
INTRODUCTION: The significance of the ectopic gastric phenotype remains unclear in patients with colorectal laterally spreading tumors (LSTs). We investigated clinicopathologic differences among LST subtypes, aiming to identify factors indicative of malignant transformation and invasion that are linked to ectopic gastric phenotype and tumor progression. MATERIALS AND METHODS: We analyzed the morphologic characteristics of 105 colorectal LSTs resected by endoscopic submucosal dissection...
October 6, 2016: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/27812392/periesophageal-pseudoaneurysms-rare-cause-of-refractory-bleeding-treated-with-transarterial-embolization
#8
Divyanshoo R Kohli, Rachit D Shah, Daniel J Komorowski, George B Smallfield
A 43-year-old female with history of systemic lupus erythematosus, prior cytomegalovirus esophagitis treated with ganciclovir, and long segment Barrett's esophagus (Prague class C8 M9) with high grade dysplasia treated with radiofrequency ablation presented to the hospital with hematemesis. An upper gastrointestinal endoscopy showed multiple esophageal ulcers with active arterial spurting which could not be controlled with endoscopic interventions including placement of hemostatic clips. An emergent angiogram demonstrated actively bleeding saccular dilations (pseudoaneurysms) in the esophageal branches of the lower thoracic aorta as well as left gastric artery for which gelfoam and coil embolization was initially successful...
2016: Case Reports in Gastrointestinal Medicine
https://www.readbyqxmd.com/read/27795812/mucins-in-neoplasms-of-pancreas-ampulla-of-vater-and-biliary-system
#9
REVIEW
Dimitrios Moschovis, Giorgos Bamias, Ioanna Delladetsima
Tumors of the pancreas, the ampulla of Vater, and the extrahepatic and intrahepatic bile ducts have significant histological similarities due to the common embryonic origin of the pancreatobiliary system. This obviates the need for discovery of biomarkers with diagnostic and prognostic value for these tumors. Mucins, especially MUC-1, -2, -4 and -5AC, are important candidates for developing into such reliable biomarkers. Increased expression of MUC1 occurs in pancreatic ductal adenocarcinomas and is associated with increased degrees of dysplasia in pancreatic intraepithelial neoplasia (PanIN)...
October 15, 2016: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/27782889/clinical-outcomes-of-endoscopic-surveillance-for-gastric-ulcers-in-populations-with-a-high-prevalence-of-gastric-cancer
#10
Young Bae Lee, Jaeho Han, Jeong Hyeon Cho, Hong Sub Lee
BACKGROUND/AIMS: Although surveillance endoscopy is recommended after the treatment of a benign gastric ulcer in Korea, improved survival, secondary to an endoscopic follow-up strategy, is controversial. Thus, the aim of this study was to understand the results of gastric ulcer surveillance endoscopy and to individualize surveillance endoscopy by analyzing known risk factors for gastric cancer. MATERIALS AND METHODS: In total, 599 (M:F=424:175, median age=55.4 years) patients who were diagnosed with a gastric ulcer and who underwent follow-up endoscopy between January 2003 and August 2014 were retrospectively enrolled in this study...
September 2016: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/27780943/the-prevalence-of-colonic-neoplasm-in-cryptogenic-pyogenic-liver-abscess-a-prospectively-enrolled-cross-sectional-study
#11
Nae Yun Heo, Young Mi Hong, Tae Oh Kim, Young Soo Moon, Sung Yeun Yang, Seung Ha Park, Jongha Park, Joon Hyuk Choi, Sung Min Kim, Ki Tae Yoon, Mong Cho, Minkyung Oh
Background/Aims: Several studies suggest that pyogenic liver abscess (PLA) is associated with colon neoplasm. A colonoscopic exam for cryptogenic PLA might detect a hidden colon neoplasm, through which intestinal flora can be transmitted into the liver. However, there are no prospectively enrolled cross-sectional data for colonic neoplasm in cryptogenic PLA. Methods: Patients with PLA were prospectively enrolled from two university hospitals. Among them, all the patients with cryptogenic PLA were recommended for colonoscopic exam to check for colonic neoplasm...
October 25, 2016: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/27767239/morphology-and-genetics-of-pyloric-gland-adenomas-in-familial-adenomatous-polyposis
#12
Wenzel M Hackeng, Elizabeth A Montgomery, Francis M Giardiello, Aatur D Singhi, Marija Debeljak, James R Eshleman, Michael Vieth, G Johan A Offerhaus, Laura D Wood, Lodewijk A A Brosens
BACKGROUND: Gastric pyloric gland adenomas (PGAs) are rare epithelial polyps that are more commonly found in autoimmune atrophic gastritis and familial adenomatous polyposis. Little is known about the morphology and genetics of PGAs in familial adenomatous polyposis. AIMS: PGAs in familial adenomatous polyposis are studied morphologically and genetically. Findings in FAP associated PGAs are compared to sporadic PGAs and related lesions such as oxyntic gland adenoma (OGA) to increase our understanding of these rare polyps...
October 21, 2016: Histopathology
https://www.readbyqxmd.com/read/27747283/effectiveness-of-systematic-alphanumeric-coded-endoscopy-for-diagnosis-of-gastric-intraepithelial-neoplasia-in-a-low-socioeconomic-population
#13
Nancy Roxana Machaca Quea, Fabian Emura, Fernando Barreda Bolaños, Yuliana Salvador Arias, Fernando Antonio Arévalo Suárez, Alejandro Piscoya Rivera
Background and study aims: In the Western world, gastric cancer (GC) usually presents at an advanced stage, carrying a high mortality rate. Studies have reported that 14 % to 26 % of GCs are missed at endoscopy up to 3 years before diagnosis. Systematic Alphanumeric Coded Endoscopy (SACE) has been proposed to improve quality of esophagogastroduodenoscopy (EGD) by facilitating a complete examination of the upper gastrointestinal tract. This prospective cross-sectional study was designed to determine the frequency of gastric intraepithelial neoplasia (GIN) by using the SACE approach in cohort of patients from low socioeconomic level...
October 2016: Endoscopy International Open
https://www.readbyqxmd.com/read/27747281/first-reports-of-esophageal-adenocarcinoma-with-white-globe-appearance-in-japanese-and-caucasian-patients
#14
Yusuke Tonai, Ryu Ishihara, Yasushi Yamasaki, Takashi Kanesaka, Sachiko Yamamoto, Tomofumi Akasaka, Noboru Hanaoka, Yoji Takeuchi, Koji Higashino, Noriya Uedo, Yasuhiko Tomita, Hiroyasu Iishi
Background and study aims: Better endoscopic diagnosis in case of Barrett's esophagus is still needed. White globe appearance (WGA) is a novel endoscopic marker for gastric adenocarcinoma, with high sensitivity for differentiating between gastric cancer/high-grade dysplasia and other lesions. We report 2 cases of esophageal adenocarcinoma with WGA. In Case 1, esophagogastroduodenoscopy (EGD) revealed a 10-mm esophageal adenocarcinoma in a 48-year-old Japanese woman with short-segment Barrett's esophagus. A small (< 1 mm) white globular lesion, typical of WGA, was observed under the epithelium by magnifying narrow-band imaging...
October 2016: Endoscopy International Open
https://www.readbyqxmd.com/read/27743162/mir-24-3p-regulates-progression-of-gastric-mucosal-lesions-and-suppresses-proliferation-and-invasiveness-of-n87-via-peroxiredoxin-6
#15
Qian Li, Nina Wang, Hong Wei, Chao Li, Jing Wu, Guibin Yang
BACKGROUND: MicroRNAs, targeting mRNAs of cancer-associated genes, are often aberrantly expressed in human gastric cancer (GC). AIM: We have examined the possible role and mechanisms of miRNA regulation of Prdx-6 in the development and progression of H. pylori-related gastric mucosal lesions. METHODS: First, miR-24-3p was predicted to target Prdx-6, and this negative regulation was validated by luciferase reporter analyses, Western blot, and quantitative RT-PCR...
December 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/27740966/-simple-mucinous-cyst-of-the-pancreas-a-clinicopathologic-analysis-of-39-examples-of-a-diagnostically-challenging-entity-distinct-from-intraductal-papillary-mucinous-neoplasms-and-mucinous-cystic-neoplasms
#16
Alyssa M Krasinskas, Gerard J Oakley, Pelin Bagci, Kee-Taek Jang, Shih-Fan Kuan, Michelle D Reid, Ipek Erbarut, Volkan Adsay
Pancreatic cysts >1 cm lined by nonpapillary mucinous epithelium without ovarian-type stroma pose diagnostic challenges. The term "simple mucinous cyst" was recently proposed for this entity. Our goal was to determine the clinicopathologic characteristics of these cysts, as they have not been previously described. Of the 39 patients with pancreatic resections included in this study, the mean age was 65 years and the female-to-male ratio was 4:1. The characteristics of the cysts are as follows: 82% had elevated cyst fluid carcinoembryonic antigen levels, 67% were unilocular, 69% occurred in the body/tail, 92% did not communicate with pancreatic ducts, the mean size was 2...
October 12, 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27729612/deletion-of-iqgap1-promotes-helicobacter-pylori-induced-gastric-dysplasia-in-mice-and-acquisition-of-cancer-stem-cell-properties-in-vitro
#17
Emilie Bessède, Silvia Molina, Luis Acuña Amador, Pierre Dubus, Cathy Staedel, Lucie Chambonnier, Alice Buissonnière, Elodie Sifré, Alban Giese, Lucie Bénéjat, Benoît Rousseau, Pierre Costet, David B Sacks, Francis Mégraud, Christine Varon
Helicobacter pylori infection is responsible for gastric carcinogenesis but host factors are also implicated. IQGAP1, a scaffolding protein of the adherens junctions interacting with E-cadherin, regulates cellular plasticity and proliferation. In mice, IQGAP1 deficiency leads to gastric hyperplasia. The aim of this study was to elucidate the consequences of IQGAP1 deletion on H. pylori-induced gastric carcinogenesis.Transgenic mice deleted for iqgap1 and WT littermates were infected with Helicobacter sp., and histopathological analyses of the gastric mucosa were performed...
October 6, 2016: Oncotarget
https://www.readbyqxmd.com/read/27725648/clinical-outcomes-following-recurrence-of-intestinal-metaplasia-after-successful-treatment-of-barrett-s-esophagus-with-radiofrequency-ablation
#18
Athidi Guthikonda, Cary C Cotton, Ryan D Madanick, Melissa B Spacek, Susan E Moist, Kathleen Ferrell, Evan S Dellon, Nicholas J Shaheen
OBJECTIVES: Radiofrequency ablation (RFA) is an effective treatment for Barrett's esophagus (BE). However, recurrence of BE after initially successful RFA is common, and outcomes following recurrence not well described. We report the outcomes associated with recurrence following initially successful RFA. METHODS: We performed a retrospective cohort study of 306 patients treated with RFA for dysplastic BE. Complete eradication of intestinal metaplasia (CE-IM) was defined as complete histological and endoscopic remission of IM...
October 11, 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27698846/expression-of-early-growth-response-gene-1-in-precancerous-lesions-of-gastric-cancer
#19
Seon-Young Park, Ji-Young Kim, Su-Mi Lee, Jin Ook Chung, Kyung-Hwa Lee, Chung-Hwan Jun, Chang-Hwan Park, Hyun-Soo Kim, Sung-Kyu Choi, Jong-Sun Rew, Young-Do Jung, Yong Han Lee
Several studies have demonstrated a correlation between the expression of early growth response gene-1 (EGR-1) and the progression of gastric cancers at advanced stages. However, the effects of EGR-1 expression on human gastric cancer progression, particularly on precancerous lesions, have not been investigated. In this study, we evaluate EGR-1 expression levels in target mucosa from patients with early gastric cancer and precancerous lesions, and assess whether EGR-1 expression affects the oncogenic phenotypes of human gastric cancer cells...
October 2016: Oncology Letters
https://www.readbyqxmd.com/read/27686105/histomorphologic-features-of-early-gastric-carcinoma-treated-by-endoscopic-submucosal-dissection-relation-to-efficiency-of-endoscopic-resection
#20
Katarzyna Karpińska-Kaczmarczyk, Andrzej Białek, Magdalena Lewandowska, Ewa Dobak, Małgorzata Ławniczak, Elżbieta Urasińska
OBJECTIVE: Early gastric cancer (EGC) is defined as cancer invasion confined to the mucosa or submucosa, irrespective of lymph node metastasis. Recently endoscopic submucosal dissection (ESD) has been widely accepted for the treatment for dysplasia and EGC without lymph node metastases. While the method has been advanced in Far East countries, ESD is still being developed in Europe and has not gained enough popularity although it has been recommended as the treatment of choice for superficial gastric neoplastic lesions by European Society of Gastrointestinal Endoscopy (ESGE) in 2015...
December 2016: Scandinavian Journal of Gastroenterology
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