keyword
MENU ▼
Read by QxMD icon Read
search

Propranolol

keyword
https://www.readbyqxmd.com/read/29679943/photocatalytic-decomposition-of-selected-biologically-active-compounds-in-environmental-waters-using-tio-2-polyaniline-nanocomposites-kinetics-toxicity-and-intermediates-assessment
#1
Daniela V Šojić Merkulov, Vesna N Despotović, Nemanja D Banić, Sanja J Armaković, Nina L Finčur, Marina J Lazarević, Dragana D Četojević-Simin, Dejan Z Orčić, Marija B Radoičić, Zoran V Šaponjić, Mirjana I Čomor, Biljana F Abramović
A comprehensive study of the removal of selected biologically active compounds (pharmaceuticals and pesticides) from different water types was conducted using bare TiO2 nanoparticles and TiO2 /polyaniline (TP-50, TP-100, and TP-150) nanocomposite powders. In order to investigate how molecular structure of the substrate influences the rate of its removal, we compared degradation efficiency of the initial substrates and degree of mineralization for the active components of pharmaceuticals (propranolol, and amitriptyline) and pesticides (sulcotrione, and clomazone) in double distilled (DDW) and environmental waters...
April 18, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29677103/ocular-delivery-system-for-propranolol-hydrochloride-based-on-nanostructured-lipid-carrier
#2
Behzad Sharif Makhmal Zadeh, Hassan Niro, Fakher Rahim, Golbarg Esfahani
One drawback of traditional forms of medical ocular dosage is drug dilution by tear; moreover, drugs are rapidly drained away from pre-corneal cavity by tear flow and lacrimo-nasal drainage. Prolonging contact time with different strategies and mucoadhesive vehicles will help to continuously deliver drugs to the eyes. For this study, we prepared and evaluated the effects of a nanostructure lipid carrier (NLC) on propranolol hydrochloride as a hydrophilic drug model for rabbit corneal permeation. Propranolol hydrochloride NLC was prepared using cold homogenization...
April 20, 2018: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/29676236/monoamine-involvement-in-the-antidepressant-like-effect-of-%C3%AE-caryophyllene
#3
Danillo Ramos Oliveira, Dayane Moreira Silva, Iziara Ferreira Florentino, Adriane de Brito, James Oluwagbamigbe Fajemiroye, Daiany Priscilla Bueno Silva, Fabio da Rocha, Elson Alves Costa, Pablinny Galdino De Carvalho
This study was conducted to evaluate the antidepressant-like activity of sesquiterpene compound β-caryophyllene (BCP) for the possible contribution of the monoamine and hippocampal levels of brain-derived neurotrophic factor (BDNF). Male albino Swiss mice were subjected to the forced swimming test after acute treatment and to the tail suspension test after repeated treatment. Hippocampal levels of BDNF were assayed by enzyme-linked immunosorbent assay. The anti-immobility effect of BCP was reverted by pretreatment with inhibitor of catecholamines α-methyl-p-tyrosine (100 mg/kg, i...
April 20, 2018: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/29675365/mesenteric-infantile-hemangioma-diagnostic-work-up
#4
Francesco Esposito, Marco Di Serafino, Rosa Severino, Zukhra Vafina, Dolores Ferrara, Massimo Zeccolini
A very rare localization of infantile hemangioma (IH) is mesentery. It may manifest with intra-luminal or intra-peritoneal bleeding. Here there is the case of a 45-day-old infant, presenting with anemia and poor growth, subsequently referred to an uncommon hemangioma of the mesentery. As well as for most of IH, conservative treatment with only propranolol resulted in the disappearance of the lesion. Here we analyze ultrasound and magnetic resonance (MR) features of this uncommon lesion, trying to underline main characteristics at imaging in order to monitor the response to therapy...
March 2018: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29673261/medical-surgical-and-wound-care-management-of-ulcerated-infantile-hemangiomas-a-systematic-review
#5
Jane Y Wang, Arvin Ighani, Ana P Ayala, Sadanori Akita, Irene Lara-Corrales, Afsaneh Alavi
Ulcerated infantile hemangiomas may present a therapeutic challenge, especially if there is concurrent hemorrhage or infection. The aim of this study was to systematically review the published evidence on the treatment of ulcerated hemangiomas, focusing on wound healing as the outcome of interest. We searched MEDLINE, Embase, SCOPUS, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and Web of Science from inception to July 2016. Seventy-seven studies met our inclusion criteria. One study was a randomized controlled trial, 30 were observational studies, and 46 were case reports or case series...
April 1, 2018: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29670504/clozapine-induced-cardiovascular-side-effects-and-autonomic-dysfunction-a-systematic-review
#6
Jessica W Y Yuen, David D Kim, Ric M Procyshyn, Randall F White, William G Honer, Alasdair M Barr
Background: Clozapine is the antipsychotic of choice for treatment-resistant schizophrenia and has minimal risk for extrapyramidal symptoms. Therapeutic benefits, however, are accompanied by a myriad of cardiometabolic side-effects. The specific reasons for clozapine's high propensity to cause adverse cardiometabolic events remain unknown, but it is believed that autonomic dysfunction may play a role in many of these. Objective: This systematic review summarizes the literature on autonomic dysfunction and related cardiovascular side effects associated with clozapine treatment...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29667726/interventions-for-infantile-haemangiomas-of-the-skin
#7
REVIEW
Monica Novoa, Eulalia Baselga, Sandra Beltran, Lucia Giraldo, Ali Shahbaz, Hector Pardo-Hernandez, Ingrid Arevalo-Rodriguez
BACKGROUND: Infantile haemangiomas (previously known as strawberry birthmarks) are soft, raised swellings of the skin that occur in 3% to 10% of infants. These benign vascular tumours are usually uncomplicated and tend to regress spontaneously. However, when haemangiomas occur in high-risk areas, such as near the eyes, throat, or nose, impairing their function, or when complications develop, intervention may be necessary. This is an update of a Cochrane Review first published in 2011...
April 18, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29667422/intestinal-permeability-of-mitragynine-in-rats-using-in-situ-absorption-model
#8
J D Yuvenesan Jagabalan, Vikneswaran Murugaiyah, Hadzliana Zainal, Sharif Mahsufi Mansor, Surash Ramanathan
The intestinal permeability of mitragynine was investigated in situ using a single pass intestinal perfusion (SPIP) absorption model, in small intestine of rat using mitragynine in the absence/presence of the permeability markers, P-gp and/or CYP3A4 inhibitors. Mitragynine demonstrated high intestinal permeability (Peff of 1.11 × 10-4  cm/s) that is in the range of highly permeable drugs such as propranolol (Peff of 1.27 × 10-4  cm/s) indicating that it readily crosses the intestine. The addition of azithromycin (P-glycoprotein inhibitor) and ciprofloxacin (CYP3A4 inhibitor) or combination of both has no effect on intestinal permeability of mitragynine across the rat small intestine...
April 18, 2018: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/29666796/plc%C3%AE-induced-ca-2-oscillations-in-mouse-eggs-involve-a-positive-feedback-cycle-of-ca-2-induced-insp-3-formation-from-cytoplasmic-pip-2
#9
Jessica R Sanders, Bethany Ashley, Anna Moon, Thomas E Woolley, Karl Swann
Egg activation at fertilization in mammalian eggs is caused by a series of transient increases in the cytosolic free Ca2+ concentration, referred to as Ca2+ oscillations. It is widely accepted that these Ca2+ oscillations are initiated by a sperm derived phospholipase C isoform, PLCζ that hydrolyses its substrate PIP2 to produce the Ca2+ releasing messenger InsP3 . However, it is not clear whether PLCζ induced InsP3 formation is periodic or monotonic, and whether the PIP2 source for generating InsP3 from PLCζ is in the plasma membrane or the cytoplasm...
2018: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/29665992/role-of-intralesional-bleomycin-and-intralesional-triamcinolone-therapy-in-residual-haemangioma-following-propranolol
#10
V Pandey, P Tiwari, S P Sharma, R Kumar, O P Singh
With the emergence of propranolol as the first choice of treatment for problematic infantile haemangioma at many centres, the number of patients with a partial or non-response to propranolol has also been growing. This study investigated the role of intralesional bleomycin and triamcinolone in patients with residual disease following propranolol therapy for infantile haemangioma. Sixty-seven patients with residual haemangioma were assigned randomly to receive either intralesional bleomycin (group A, n=36) or intralesional triamcinolone (group B, n=31)...
April 14, 2018: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29664206/pedf-vegf-ratio-plays-a-crucial-role-in-the-spontaneous-regression-of-infant-hemangioma-and-the-therapeutic-effect-of-propranolol
#11
Liuqing Zhu, Jinye Xie, Zhenyin Liu, Zhijian Huang, Mao Huang, Haofan Yin, Weiwei Qi, Zhonghan Yang, Ti Zhou, Guoquan Gao, Jing Zhang, Xia Yang
Infantile hemangioma (IH) is a benign tumor that is formed by aberrant angiogenesis and that undergoes spontaneous regression over time. Propranolol, the first-line therapy for IH, inhibits angiogenesis by downregulating the activation of the VEGF pathway, which is hyperactivated in IH. However, this treatment is reportedly ineffective for 10% of tumors, and 19% of patients relapse after propranolol treatment. Both pro-angiogenic and anti-angiogenic factors regulate angiogenesis, and PEDF is the most effective endogenous anti-angiogenic factor...
April 17, 2018: Cancer Science
https://www.readbyqxmd.com/read/29653257/%C3%AE-adrenergic-receptors-reduce-the-threshold-for-induction-and-stabilization-of-ltp-and-enhance-its-magnitude-via-multiple-mechanisms-in-the-ventral-but-not-the-dorsal-hippocampus
#12
Vassilios Papaleonidopoulos, Costas Papatheodoropoulos
The hippocampus is a functionally heterogeneous structure with the cognitive and emotional signal processing ascribed to the dorsal (DH) and the ventral hippocampus (VH) respectively. However, the underlying mechanisms are poorly understood. Noradrenaline is released in hippocampus during emotional arousal modulating synaptic plasticity and memory consolidation through activation of β adrenergic receptors (β-ARs). Using recordings of field excitatory postsynaptic potentials from the CA1 field of adult rat hippocampal slices we demonstrate that long-term potentiation (LTP) induced either by theta-burst stimulation (TBS) that mimics a physiological firing pattern of hippocampal neurons or by high-frequency stimulation is remarkably more sensitive to β-AR activation in VH than in DH...
April 10, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29651388/the-effect-of-oral-propranolol-versus-oral-corticosteroids-in-management-of-pediatric-hemangiomas
#13
Adil Ali, Umme Aiman, Mohd Azam Haseen, Mohd Altaf Mir, Imran Ghani, Ragya Bharadwaj, Mohd Yaseen
BACKGROUND: Hemangiomas are the most common benign tumors of infancy. This study evaluated the efficacy of oral propranolol comparing to oral steroids in management of pediatric hemangiomas. METHODS: In North India from January 2012 to January 2015, sixty children <6 years old with superficial hemangiomas were divided into 2 groups; oral propranolol vs. oral prednisolone. All participants were assessed for electrocardiogram, heart rate, blood pressure and sugar and initial therapy was started using 1 mg/kg and in absence of adverse effects, 2 mg/kg was administered after 2 weeks...
January 2018: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29649583/noradrenergic-%C3%AE-receptor-antagonism-in-the-basolateral-amygdala-impairs-reconsolidation-but-not-extinction-of-alcohol-self-administration-intra-bla-propranolol-impairs-reconsolidation-of-alcohol-self-administration
#14
Rose Chesworth, Laura H Corbit
A critical barrier to recovery from alcohol addiction is relapse propensity. Alcohol cues can trigger relapse, and pharmacologically facilitating processes such as extinction, which decreases cue associations, may help prevent relapse. The noradrenergic system mediates extinction learning for alcohol; however, the neural locus of this effect is unknown. This study sought to determine whether the basolateral amygdala (BLA), a region critical for fear extinction, also mediates extinction of alcohol seeking. Hooded Wistar rats (N = 12-15 per experiment) were implanted with bilateral cannula targeting the BLA and trained to lever press for 10% ethanol during auditory or visual cues...
April 9, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29621088/treatment-of-facial-infantile-hemangioma-comparative-study-between-propranolol-and-ethanolamine-oleate
#15
Thais Miguel do Monte Lameiro, Rafael Denadai, João Carlos Pereira-Filho, Cesar Augusto Raposo-Amaral, Cassio Eduardo Raposo-Amaral
BACKGROUND: Infantile hemangiomas (IH) are the most common benign vascular tumors in childhood. Approximately 10% to 15% of these tumors require drug or surgical intervention. There are many options for IH treatment, of which propranolol is currently considered the gold standard. This study aims to compare the therapeutic results of 2 distinct drugs (ethanolamine oleate and propranolol), in order to increase the available therapeutic arsenal for the treatment of IH, thereby benefiting a larger group of patients...
April 4, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29611347/activation-of-the-sympathetic-nervous-system-suppresses-mouse-white-adipose-tissue-hyperplasia-through-the-%C3%AE-1-adrenergic-receptor
#16
Mary K Schneider, Bingzhong Xue, Hang Shi
Adipose tissue (AT) expands via both hypertrophy and hyperplasia during the development of obesity. While AT hypertrophy involves the increase in size of existing adipocytes, hyperplasia is the process of creating new adipocytes from the pool of adipocyte precursor cells (APCs), which includes adipocyte progenitor cells and preadipocytes. Prior studies have implicated a role of the sympathetic nervous system (SNS) in regulation of hyperplasia in white adipose tissue (WAT). Here, we aimed to determine the mechanisms underlying SNS regulation of APC proliferation in mouse WAT...
April 2018: Physiological Reports
https://www.readbyqxmd.com/read/29610165/a-case-report-of-2-sirolimus-related-deaths-among-infants-with-kaposiform-hemangioendotheliomas
#17
Hanru Ying, Congzhen Qiao, Xi Yang, Xiaoxi Lin
Kaposiform hemangioendothelioma (KHE) is a rare infiltrative vascular tumor that is potentially life-threatening when presenting with Kasabach-Merritt phenomenon (KMP). KMP is clinically characterized as severe thrombocytopenia and hypofibrinogenemia and therefore is associated with a high mortality rate. There is no standard of cure for KHE currently. Potential medications, including corticosteroids, propranolol, and chemotherapy drugs such as sirolimus, are often used for alleviating KHE symptoms. Although some case reports of sirolimus treatment have shown promising results with recovered coagulant parameters, the off-target effects may cause severe problems...
April 2018: Pediatrics
https://www.readbyqxmd.com/read/29610164/-pneumocystis-jirovecii-pneumonia-during-sirolimus-therapy-for-kaposiform-hemangioendothelioma
#18
Thomas B Russell, Emily K Rinker, Claire S Dillingham, Laurence B Givner, Thomas W McLean
Sirolimus is an effective therapy for children with kaposiform hemangioendothelioma with or without the Kasabach-Merritt phenomenon. We report the case of a child with kaposiform hemangioendothelioma and the Kasabach-Merritt phenomenon who developed Pneumocystis carinii pneumonia (PCP) while on sirolimus and a prednisolone taper, after lack of adequate response to prednisolone, propranolol, and vincristine. He had a prompt positive clinical and laboratory response to sirolimus, but 4 weeks after starting it, at the age of 4 months, he developed PCP...
April 2018: Pediatrics
https://www.readbyqxmd.com/read/29609011/relaxant-effect-of-lippia-origanoides-essential-oil-in-guinea-pig-trachea-smooth-muscle-involves-potassium-channels-and-soluble-guanylyl-cyclase
#19
Pedro Modesto Nascimento Menezes, Mariana Coelho Brito, Gabriela Olinda de Paiva, Carine Oliveira Dos Santos, Lenaldo Muniz de Oliveira, Luciano Augusto de Araújo Ribeiro, Julianeli Tolentino de Lima, Angélica Maria Lucchese, Fabrício Souza Silva
ETHNOPHARMACOLOGICAL RELEVANCE: Lippia origanoides H.B.K. is an aromatic species used in folk medicine to treat respiratory diseases, including asthma. AIM OF THE STUDY: The aim of this work was to evaluate the relaxing potential and mechanism of action of the L. origanoides (LOO) essential oil in isolated guinea-pig trachea MATERIALS AND METHODS: Leaves from L. origanoides were collected at experimental fields under organic cultivation, at the Forest Garden of Universidade Estadual de Feira de Santana...
March 30, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29608474/cleft-palate-repair-using-single-flap-palatoplasty-in-patient-with-associated-palatal-hemangioma
#20
Murat Kara, Mert Calis, Canan Akyuz, Figen Ozgur
Hemangiomas are the most common tumors of childhood with an average incidence of 10%. It is unusual for hemangiomas, which are already rarely seen isolated on the palate, to coexist with cleft palate as in the authors' patient. Four months old baby was admitted with isolated Veau 2 cleft palate and a red-purple colored raised lesion involving almost the whole right side of the hard palate. Magnetic resonance imaging revealed intensive contrasting solid nodule with a lobulated contour that was covering the right half of the hard palate, measuring 2...
March 30, 2018: Journal of Craniofacial Surgery
keyword
keyword
1759
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"