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Celiac sprue

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https://www.readbyqxmd.com/read/27803820/seronegative-intestinal-villous-atrophy-a-diagnostic-challenge
#1
Cláudio Martins, Cristina Teixeira, Suzane Ribeiro, Daniel Trabulo, Cláudia Cardoso, João Mangualde, Ricardo Freire, Ana Luísa Alves, Élia Gamito, Isabelle Cremers, Ana Paula Oliveira
Celiac disease is the most important cause of intestinal villous atrophy. Seronegative intestinal villous atrophy, including those that are nonresponsive to a gluten-free diet, is a diagnostic challenge. In these cases, before establishing the diagnosis of seronegative celiac disease, alternative etiologies of atrophic enteropathy should be considered. Recently, a new clinical entity responsible for seronegative villous atrophy was described-olmesartan-induced sprue-like enteropathy. Herein, we report two uncommon cases of atrophic enteropathy in patients with arterial hypertension under olmesartan, who presented with severe chronic diarrhea and significant involuntary weight loss...
2016: Case Reports in Gastrointestinal Medicine
https://www.readbyqxmd.com/read/27784420/a-night-of-no-sleep
#2
Bhanu Prakash Kolla, Meghna P Mansukhani, Steven I Altchuler
Ms. C, a 20-year-old female was referred for a sleep evaluation for hypersomnia. She reported increasing sleepiness over a period of one year. She described a pattern of retiring to bed at 2000 hours with an initial sleep latency of 10 minutes. She would sleep uninterrupted until 0630 hours and wake to an alarm clock. She avoided napping during the day. Her history was otherwise not suggestive of narcolepsy or sleep apnea. She was not on any medications and had a medical history significant only for celiac sprue...
October 20, 2016: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/27753658/immunohistochemical-expression-of-antitissue-transglutaminase-2-in-tissue-injuries-an-interpretation-beyond-celiac-disease
#3
Prasenjit Das, Ramakant Rawat, Anil K Verma, Geetika Singh, Archana G Vallonthaiel, Rajni Yadav, Gaurav P S Gahlot, Amit K Dinda, Vineet Ahuja, Siddhartha Datta Gupta, Sanjay K Agarwal, Govind K Makharia
Tissue transglutaminase 2 enzyme plays a diverse role in intracellular and extracellular functioning. Aberrant expression of anti-TG2 antibody has recently been proposed for extraintestinal identification of celiac disease (CeD), but its utility is questionable. To examine whether anti-TG2 immunohistochemical (IHC) staining can be of diagnostic value in identifying extraintestinal involvement in CeD, tissue blocks of patients with IgA nephropathies (IgAN), minimal change disease, membranous glomerulonephritis, membrano-proliferative glomerulonephritis, normal kidney, intestinal biopsies from CeD, tropical sprue, nonspecific duodenitis, and inflammatory bowel disease; liver biopsies from patients with chronic hepatitis B and C, acute liver failure (ALF), and CeD-associated liver diseases were retrieved and subjected to IHC staining for anti-tissue transglutaminase 2 enzyme...
October 7, 2016: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/27636919/-malabsorption-is-a-leading-clinical-sign-of-small-bowel-disease
#4
A I Parfenov, L M Krums
The paper presents a variety of clinical manifestations of malabsorption syndrome (MAS) in celiac disease, collagenous sprue, Whipple's disease, Crohn's disease, intestinal lymphangiectasia, amyloidosis, common variable immune deficiency, and treatment of short bowel syndrome. It shows the specific features of the pathophysiology, diagnosis, and treatment of MAS in small bowel diseases.
2016: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/27620860/comparison-of-clinical-features-treatment-and-outcomes-of-collagenous-sprue-celiac-disease-and-collagenous-colitis
#5
Nan Lan, Bo Shen, Lisi Yuan, Xiuli Liu
BACKGROUND: Collagenous sprue (CS) is a rare form of enteropathy that had been reported to be associated with celiac disease (CD) and collagenous colitis (CC). The aim of our study was to compare the clinical features, treatments and outcomes of CS, CD, and CC. METHODS: All patients with histologic diagnosis of CS, CD or CC with complete clinical data were extracted from our pathology database between 1990 and 2015. Demographic and clinical features were recorded along with treatments and outcomes...
September 13, 2016: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27486350/elderly-onset-celiac-disease-a-narrative-review
#6
REVIEW
Maria Cappello, Gaetano C Morreale, Anna Licata
Celiac sprue is a chronic disease, which usually occurs in children and young adults. However, it can develop in any age group, and the prevalence is increasing even in the elderly population. The atypical patterns of clinical presentation in this age group sometimes can cause a delay in diagnosis. Given the lower sensitivity and specificity of serological tests in the aged population, clinical suspect often arises in the presence of complications (autoimmune disorders, fractures, and finally, malignancy) and must be supported by endoscopic and imaging tools...
2016: Clinical Medicine Insights. Gastroenterology
https://www.readbyqxmd.com/read/27446852/duodenal-villous-atrophy-in-a-ttg-negative-patient-taking-olmesartan-a-case-report-and-review-of-the-literature
#7
Tasha Kulai, Thomas Arnason, Donald MacIntosh, John Igoe
Olmesartan, an angiotensin II receptor antagonist used to treat hypertension, is associated with few adverse effects. Here, a case of severe sprue-like enteropathy and acute kidney injury is described in a 68-year-old male taking olmesartan for 3-4 years. He presented to hospital with a five-week history of diarrhea, vomiting, and a 20 lb weight loss. Anti-TTG was negative with a normal IgA. Biopsies of the distal duodenum and duodenal cap revealed marked blunting of the villi with near complete villous atrophy of the biopsies from the bulb...
2016: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27195041/the-maladies-of-malabsorption
#8
Rashmi Patnayak, Vaikkakara Suresh, Amitabh Jena, Kadiyala Madhu, Bobbit Venkatesh Phaneendra, Venkatrami Reddy
Malabsorption syndrome (MAS) is a common condition in India. In Indian adults, tropical sprue and celiac disease are leading causes of MAS. Sometimes, the diagnosis of MAS may pose a challenge due to the varied signs and symptoms. We present a case of MAS in a young female, whose presenting symptoms were mainly neurological. She was successfully treated under regular follow-up for the past 6 years without any symptoms.
January 2016: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/27109007/clinical-laboratory-serological-and-histological-profile-of-sprue-like-enteropathy-associated-with-olmesartan-use
#9
Esteban Sáez González, Francia Carolina Díaz Jaime, Adolfo Del Val Antoñana
Olmesartan is one of the various angiotensin II antagonists currently used for the management of high blood pressure. A sprue-like enteropathy was first described in 2012 in association with this antihypertensive drug. An observational, descriptive study was carried out on a series of 12 patients who met the clinical, histopathological, and outcome criteria for olmesartan-related sprue-like enteropathy from May 2013 to December 2015. All patients had watery diarrhea, weight loss, and negative celiac serology...
April 25, 2016: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/26997446/olmesartan-associated-sprue-like-enteropathy-a-systematic-review-with-emphasis-on-histopathology
#10
REVIEW
Nina Burbure, Benjamin Lebwohl, Carolina Arguelles-Grande, Peter H R Green, Govind Bhagat, Stephen Lagana
Sprue-like enteropathy associated with the angiotensin II receptor blocker (ARB) olmesartan was first described in 2012, and a number of cases have since been reported. This syndrome is characterized by severe diarrhea and sprue-like histopathologic findings in the intestine, often with increased subepithelial collagen. The incidence of this adverse drug reaction is not entirely clear, although it is thought to be rare. It is also not well established if other ARBs cause such a syndrome, although case reports suggest they can...
April 2016: Human Pathology
https://www.readbyqxmd.com/read/26925975/sprue-like-enteropathy-linked-to-olmesartan
#11
Amaia Campos Ruiz, Leire Urtasun Arlegui, Carlos Marra-López Valenciano
Olmesartan is a therapy used for the management of hypertension available since 2002. A sprue like enteropathy associated with olmesartan has been first described in 2012. Endoscopic and histopathological findings are partial or total villous atrophy, mimicking a Celiac Disease. We explain two cases diagnosed in our hospital. Both patients took more than one year of treatment with olmesartan. In both cases, the biopsy showed duodenal villous atrophy, negative serology for celiac disease and they improved after stopping treatment with olmesartan...
May 2016: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/26884738/spectrum-of-chronic-small-bowel-diarrhea-with-malabsorption-in-indian-subcontinent-is-the-trend-really-changing
#12
Nirav Pipaliya, Meghraj Ingle, Chetan Rathi, Prateik Poddar, Nilesh Pandav, Prabha Sawant
BACKGROUND/AIMS: This study aimed to document the recent etiological spectrum of chronic diarrhea with malabsorption and also to compare features that differentiate tropical sprue from parasitic infections, the two most common etiologies of malabsorption in the tropics. METHODS: We analyzed 203 consecutive patients with malabsorption. The etiological spectrum and factors that differentiated tropical sprue from parasitic infections were analyzed. RESULTS: The most common etiology was tropical sprue (n=98, 48...
January 2016: Intestinal Research
https://www.readbyqxmd.com/read/26870134/disorders-associated-with-malabsorption-of-iron-a-critical-review
#13
REVIEW
Muhammad Saboor, Amtuz Zehra, Khansa Qamar, Moinuddin
Malabsorption is a disorder of the gastrointestinal tract that leads to defective digestion, absorption and transport of important nutrients across the intestinal wall. Small intestine is the major site where most of the nutrients are absorbed. There are three main mechanisms of malabsorption; premucosal, mucosal and postmucosal. Premucosal malabsorption is the inadequate digestion due to improper mixing of gastrointestinal enzymes and bile with chyme. This could be because of surgical resection of the small intestine or a congenital deficiency of the enzymes and bile responsible for digestion e...
November 2015: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/26831462/prospects-of-developing-medicinal-therapeutic-strategies-and-pharmaceutical-design-for-effective-gluten-intolerance-treatment
#14
Lyudmila V Savvateeva, Andrey A Zamyatnin
Gluten intolerance is an umbrella term for gluten-related disorders manifested in health decline as a result of the gluten ingestion. The spectrum of gluten-related disorders includes three major groups: autoimmune (mainly, Celiac Disease, CD, also known as Celiac Sprue, dermatitis herpetiformis, or gluten-sensitive ataxia), allergic (wheat allergy, WA), and non-autoimmune non-allergic (non-celiac gluten sensitivity, NCGS, or gluten sensitivity, GS). Pathogenesis and diagnostics of CD and WA are well established in contrast to NCGS, pathogenicity of which is still poorly understood and its symptoms are frequently misdiagnosed since most of the NCGS cases are currently identified via the process of CD and WA exclusion...
2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/26688780/gastrointestinal-disease-in-sjogren-s-syndrome-related-to-food-hypersensitivities
#15
Christine Kim-Lee, Lakshmanan Suresh, Julian L Ambrus
Patients with Sjogren's syndrome (SS) frequently have irritable bowel like symptoms (IBS). Some have celiac sprue. The current studies were designed to examine the presence of food hypersensitivities in a population of patients with SS and IBS. Ten patients were selected from the autoimmune disease clinics at SUNY at Buffalo who had SS and IBS symptoms. Food hypersensitivities were determined by specific IgG ImmunoCAP(®) assays. Symptoms of abdominal pain, bloating, diarrhea and joint pain were eliminated with dietary restriction of foods to which hypersensitivity was demonstrated...
2015: SpringerPlus
https://www.readbyqxmd.com/read/26686937/celiac-sprue-presenting-as-pseudomyocardial-infarction
#16
Muhammed Keskin, Mert İlker Hayıroğlu, Ümran Keskin, Mehmet Eren
No abstract text is available yet for this article.
June 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/26496241/prevalence-and-characteristics-of-duodenal-villous-atrophy-in-renal-transplant-patients-presenting-with-persistent-diarrhea-in-a-developing-country
#17
Farina M Hanif, Nasir Hassan Luck, Zaigham Abbas, Tahir Aziz, Syed Mujahid Hassan, Muhammed Mubarak
OBJECTIVES: Persistent diarrhea is a common complication after solid-organ transplant, including kidney transplant. Data on duodenal villous atrophy as a cause of persistent diarrhea in renal transplant recipients are scarce. MATERIALS AND METHODS: We conducted a prospective analysis of 207 patients who received renal transplants from 2009 to 2012 with persistent diarrhea and who underwent upper gastrointestinal endoscopy and duodenal biopsies. Duodenal biopsies were examined for duodenal villous atrophy...
April 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/26414468/olmesartan-associated-enteropathy-a-review-of-clinical-and-histologic-findings
#18
REVIEW
Eun-Young Karen Choi, Barbara J McKenna
Olmesartan is an antihypertensive medication belonging to the angiotensin II receptor blocker class of drugs that has recently been associated with severe enteropathy. Olmesartan-associated enteropathy is uncommon and may be difficult to recognize because of its clinical and histologic similarities to other clinical entities, including celiac sprue and autoimmune enteropathy. The purpose of this article is to review the clinical and histologic findings of olmesartan-associated enteropathy that have been reported in the literature and to discuss clinical entities to consider in the differential diagnosis of olmesartan-associated enteropathy...
October 2015: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/26387172/-endocytoscopy-new-type-of-endoscopic-examination-of-lower-gastrointestinal-and-respiratory-tract
#19
REVIEW
S S Pirogov, V V Sokolov, A D Kaprin, D V Sokolov, N N Volchenko, E S Karpova, P V Pavlov, L V Telegina, D G Sukhin, N N Pogorelov, A B Ryabov, V M Khomyakov, I A Chulikov
Majority of published data describing endocytoscopic examination of upper gastrointestinal tract mucosa, but in recent publications, it is reported, that endocytoscopy is suitable for small bowel, colon, respiratory tract and even peritoneum "optical biopsy". In number of articles possibilities of celiac sprue diagnostics with endocytoscopy is discussed, but small-bowel endocytoscopy is limited, due to absence of endocytoscopes, compatible with enteroscopes. More widely endocytoscopy is used in colon, mostly in lateral-spreading adenomas diagnostics...
2015: Experimental & Clinical Gastroenterology
https://www.readbyqxmd.com/read/26298583/computational-analysis-of-the-domain-architecture-and-substrate-gating-mechanism-of-prolyl-oligopeptidases-from-shewanella-woodyi-and-identification-of-probable-lead-molecules
#20
Priya Patil, Sinosh Skariyachan, Eshita Mutt, Swati Kaushik
Prolyl oligopeptidases (POPs) are serine proteases found in prokaryotes and eukaryotes which hydrolyze the peptide bond containing proline. The current study focuses on the analysis of POP sequences, their distribution and domain architecture in Shewanella woodyi, a Gram-negative, luminous bacterium which causes celiac sprue and similar infections in marine organisms. The POP undergoes huge interdomain movement, which allows possible route for the entry of any substrate. Hence, it offers an opportunity to understand the mechanism of substrate gating by studying the domain architecture and possibility to identify a probable drug target...
September 2016: Interdisciplinary Sciences, Computational Life Sciences
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