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Pancreatic mucinous cystic neoplasm

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https://www.readbyqxmd.com/read/28936758/mucinous-cystic-neoplasms-of-the-pancreas-high-resolution-cross-sectional-imaging-features-with-clinico-pathologic-correlation
#1
Alejandro Garces-Descovich, Kevin Beker, Manuel Castillo-Angeles, Alexander Brook, Elena Resnick, Shweta Shinagare, Robert M Najarian, Koenraad J Mortele
PURPOSE: To describe the high-resolution cross-sectional (MDCT/MRI) features of mucinous cystic neoplasms (MCN) of the pancreas with clinico-pathologic correlation; to identify imaging predictors of high-grade dysplasia/carcinoma; and to estimate MCN growth rate. MATERIALS AND METHODS: Thirty-two women (mean age: 46; range, 25-79 years) with resected MCN who underwent preoperative MDCT (n = 20) or MRI (n = 12) examinations over a 14-year period were included...
September 21, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28890216/my-treatment-approach-pancreatic-cysts
#2
Omer Basar, William R Brugge
Our treatment approach for either symptomatic or incidentally found pancreatic cysts continues to improve. The true incidence of pancreatic cysts is not known, and pancreatic cystic neoplasms, especially intraductal papillary mucinous neoplasms, are currently most commonly diagnosed and resected. This is a result of increasing awareness, widespread availability of imaging, and better understanding of the nature of pancreatic cysts as well. Recent studies on molecular analysis and devices such as microbiopsy forceps help us better define and select the treatment approach to alleviate symptoms and to prevent malignant tumors while avoiding unnecessary surgery...
September 7, 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/28879469/pancreatic-cancer-screening
#3
REVIEW
Koushik K Das, Dayna Early
PURPOSE OF REVIEW: This review describes the rationale for pancreatic cancer screening, outlines groups that are at elevated risk for pancreatic cancer, and summarizes the relative risk in each setting. We also review the methods available for performing pancreatic cancer screening and the recommended screening intervals. RECENT FINDINGS: Several genetic mutations have been identified that increase the risk for pancreatic cancer. Most are rare, however, and at-risk individuals are most often those with a strong family history of pancreatic cancer (with multiple family members affected) but no identifiable genetic mutation...
September 6, 2017: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/28875275/decision-making-for-the-management-of-cystic-lesions-of-the-pancreas-how-satisfied-are-patients-with-surgery
#4
Priya M Puri, Ammara A Watkins, Tara S Kent, Laura Maggino, Jenna Gates Jeganathan, Mark P Callery, Jeffrey A Drebin, Charles M Vollmer
INTRODUCTION: This study aims to understand patients' perspectives and satisfaction with choosing surgery for the treatment of pancreatic cystic lesions (PCLs). METHODS: A 62-question survey was administered to 113 patients who had a resection for a PCL by 12 surgeons at two pancreatic specialty centers (2004-2016). Patients' final diagnoses and perioperative outcomes were correlated to the survey's results using univariate analysis. RESULTS: Fear of cancer was quite or extremely important in most respondents' decision to have surgery (95...
September 5, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28874676/linc-ing-circulating-long-non-coding-rnas-to-the-diagnosis-and-malignant-prediction-of-intraductal-papillary-mucinous-neoplasms-of-the-pancreas
#5
Jennifer B Permuth, Dung-Tsa Chen, Sean J Yoder, Jiannong Li, Andrew T Smith, Jung W Choi, Jongphil Kim, Yoganand Balagurunathan, Kun Jiang, Domenico Coppola, Barbara A Centeno, Jason Klapman, Pam Hodul, Florian A Karreth, Jose G Trevino, Nipun Merchant, Anthony Magliocco, Mokenge P Malafa, Robert Gillies
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease that lacks effective biomarkers for early detection. We hypothesized that circulating long non-coding RNAs (lncRNAs) may act as diagnostic markers of incidentally-detected cystic PDAC precursors known as intraductal papillary mucinous neoplasms (IPMNs) and predictors of their pathology/histological classification. Using NanoString nCounter® technology, we measured the abundance of 28 candidate lncRNAs in pre-operative plasma from a cohort of pathologically-confirmed IPMN cases of various grades of severity and non-diseased controls...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28872701/natural-history-of-pancreatic-cystic-lesions-a-multicenter-prospective-observational-study-for-evaluating-the-risk-of-pancreatic-cancer
#6
Eizaburo Ohno, Yoshiki Hirooka, Hiroki Kawashima, Takuya Ishikawa, Akira Kanamori, Hideki Ishikawa, Yoji Sasaki, Koji Nonogaki, Kazuo Hara, Senju Hashimoto, Hiroshi Matsubara, Takanori Hirai, Hajime Sumi, Hiroyuki Sugimoto, Hidemi Goto
BACKGROUD AND AIM: To elucidate the natural history of pancreatic cystic lesions (PCLs), including branch-duct intraductal papillary mucinous neoplasm (BD-IPMN), via mid-term follow-up analysis of a multicenter prospective observational study (NSPINAL study). METHODS: From July 2011 to October 2016, 881 patients with PCLs were enrolled in NSPINAL study, and 664 patients with >12 months of follow-up were analysed. Every patient was asymptomatic, and endoscopic ultrasound (EUS) was performed at the initial diagnosis to exclude high-risk individuals...
September 5, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28858107/comparison-of-the-diagnostic-accuracy-of-three-current-guidelines-for-the-evaluation-of-asymptomatic-pancreatic-cystic-neoplasms
#7
Ming-Ming Xu, Shi Yin, Ali A Siddiqui, Ronald R Salem, Beth Schrope, Amrita Sethi, John M Poneros, Frank G Gress, Jeanine M Genkinger, Catherine Do, Christian A Brooks, John A Chabot, Michael D Kluger, Thomas Kowalski, David E Loren, Harry Aslanian, James J Farrell, Tamas A Gonda
Asymptomatic pancreatic cysts are a common clinical problem but only a minority of these cases progress to cancer. Our aim was to compare the accuracy to detect malignancy of the 2015 American Gastroenterological Association (AGA), the 2012 International Consensus/Fukuoka (Fukuoka guidelines [FG]), and the 2010 American College of Radiology (ACR) guidelines.We conducted a retrospective study at 3 referral centers for all patients who underwent resection for an asymptomatic pancreatic cyst between January 2008 and December 2013...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28842734/-resection-of-main-duct-and-mixed-type-ipmn-%C3%A2-5%C3%A2-mm
#8
REVIEW
G O Ceyhan, F Scheufele, H Friess
The incidence of cystic pancreatic lesions is steadily increasing due to the technical advances in imaging. Within the group of cystic pancreatic lesions intraductal papillary mucinous neoplasms (IPMNs) depict an important entity. Due to a possible progression to malignancy the clinical strategy has to be well chosen. For primary diagnostic work-up imaging by magnetic resonance imaging (MRI) with MR cholangiopancreatography (MRCP) and computed tomography (CT) scanning is recommended. Additional information can be gained by endosonography and a biopsy of the cystic lesion, allowing analysis of biomarkers, such as GNAS and KRAS mutation as wells as NLR...
August 25, 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/28836521/a-prospective-study-of-endoscopic-ultrasonography-features-cyst-fluid-carcinoembryonic-antigen-and-fluid-cytology-for-the-differentiation-of-small-pancreatic-cystic-neoplasms
#9
Ying Wang, Ningli Chai, Jia Feng, Enqiang Linghu
BACKGROUND AND OBJECTIVES: With improvements in imaging technologies, pancreatic cystic lesions (PCLs) have been increasingly identified in recent years. However, the imaging modalities used to differentiate the categories of pancreatic cysts remain limited, which may cause confusion when planning treatment. Due to progress in endoscopic ultrasonography-guided fine-needle aspiration (EUS-FNA) technology, auxiliary diagnosis by the detection of cystic fluid has become a recent trend. METHODS: From March 2015 to April 2016, 120 patients with PCLs were enrolled in this study...
August 24, 2017: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/28831506/-cystic-pancreatic-tumors-diagnostics-and-new-biomarkers
#10
REVIEW
A W Berger, T Seufferlein, A Kleger
Mortality due to pancreatic ductal adenocarcinoma (PDAC) will increase in the near future. The only curative treatment for PDAC is radical resection; however, even small carcinomas exhibit micrometastases leading to early relapse. Accordingly, detection of premalignant precursor lesions is important. In essence, PDAC develops from three precursor lesions: pancreatic intraepithelial lesions (PanIN), intraductal papillary-mucinous neoplasia (IPMN) and mucinous-cystic neoplasia (MCN). Together with serous cystic neoplasia (SCN) and solid pseudopapillary neoplasia (SPN), these cystic lesions constitute the most common cystic neoplasms in the pancreas...
August 22, 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/28815810/proteome-characterization-of-human-pancreatic-cyst-fluid-from-intraductal-papillary-mucinous-neoplasm-by-lc-ms-ms
#11
Joonho Park, Dohyun Han, Misol Do, Jongmin Woo, Joseph I Wang, Youngmin Han, Wooil Kwon, Sun-Whe Kim, Jin-Young Jang, Youngsoo Kim
RATIONALE: In recent years, the molecular components of pancreatic cyst fluid has been used for diagnosis and prognosis. Because the protein markers that are currently used in clinical tests are unreliable, proteomic studies to find new protein markers are being conducted. However, such researches have been limited due to the complexity of pancreatic cyst fluid and the immaturity of proteomic techniques. METHODS: To overcome these limitations and provide a pancreatic cyst proteome dataset, we examined cyst fluid proteome with tandem mass spectrometry...
August 15, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28697137/clinical-profile-of-pancreatic-cystic-lesions-in-von-hippel-lindau-disease-a-series-of-48-patients-seen-at-a-tertiary-institution
#12
Ayush Sharma, Saurabh Mukewar, Santhi Swaroop Vege
OBJECTIVES: Little is known about the association between pancreatic cystic lesions (PCLs) with von Hippel-Lindau disease (VHLD). In this study, we describe the clinical presentation, type of PCLs, and risk for malignancy in PCLs in VHLD. METHODS: Patients given a diagnosis of both VHLD and PCLs were identified from electronic medical records at Mayo Clinic, Rochester, MN, from January 1, 2000, to January 1, 2016. Various demographic, clinical, and radiologic variables were recorded...
August 2017: Pancreas
https://www.readbyqxmd.com/read/28697136/circulating-epithelial-cells-in-intraductal-papillary-mucinous-neoplasms-and-cystic-pancreatic-lesions
#13
Katherine E Poruk, Vicente Valero, Jin He, Nita Ahuja, John L Cameron, Matthew J Weiss, Anne Marie Lennon, Michael Goggins, Laura D Wood, Christopher L Wolfgang
OBJECTIVES: Circulating epithelial cells (CECs) are identified in the blood of patients with intraductal papillary mucinous neoplasms (IPMNs) despite the absence of malignancy. We assessed the blood of patients undergoing resection for IPMN or other benign pancreatic lesions for CECs. METHODS: Peripheral blood was collected from 26 patients prior to pancreatic resection and filtered by the ISET (Isolation by Size of Epithelial Tumor Cells) method. Circulating epithelial cells were identified with antibodies to cytokeratin and Pdx1 (pancreas and duodenal homeobox protein 1), a pancreas marker...
August 2017: Pancreas
https://www.readbyqxmd.com/read/28693619/successful-pregnancy-after-mucinous-cystic-neoplasm-with-invasive-carcinoma-of-the-pancreas-in-a-patient-with-polycystic-ovarian-syndrome-a-case-report
#14
Conisha Holloman, S J Carlan, Lohini Sundharkrishnan, Angela Guzman, Mario Madruga
BACKGROUND: The incidence of invasive cancer within a mucinous cystic neoplasm of the pancreas varies between 6 and 36%. Polycystic ovarian syndrome is a disorder characterized by hyperandrogenism and anovulatory infertility. One surgical treatment that can restore endocrine balance and ovulation in polycystic ovarian syndrome is partial ovarian destruction. Successful pregnancies following preconception pancreaticoduodenectomies (Whipple procedures) and chemoradiation to treat pancreatic neoplasms have been reported rarely but none were diagnosed with pre-cancer polycystic ovarian syndrome-associated infertility...
July 11, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28693147/pancreatic-intraductal-tubulopapillary-neoplasm-with-associated-invasive-cancer-successfully-treated-by-total-pancreatectomy-a-case-report
#15
Yuji Fujimoto, Yoshito Tomimaru, Hiromi Tamura, Kozo Noguchi, Hirotsugu Nagase, Atsushi Hamabe, Masashi Hirota, Kazuteru Oshima, Tsukasa Tanida, Tomono Kawase, Shunji Morita, Hiroshi Imamura, Takashi Iwazawa, Kenzo Akagi, Masashi Yamamoto, Tsutomu Nishida, Shiro Adachi, Keizo Dono
A 74-year-old male was admitted to Departments of Surgery, Toyonaka Municipal Hospital (Osaka, Japan) for treatment of a pancreatic tumor. Contrast enhanced computed tomography (CT) revealed a mass with small cystic lesions in the pancreatic head and body. Fluorodeoxyglucose-positron emission tomography/CT revealed an abnormal uptake of fluorodeoxyglucose, corresponding to the mass lesions. Upper gastrointestinal endoscopy revealed rough mucosa near the opening of the accessory pancreatic duct, and the mucosa biopsy exhibited adenocarcinoma with no mucin observed...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28682431/uptodate-in-the-assessment-and-management-of-intraductal-papillary-mucinous-neoplasms-of-the-pancreas
#16
D Pagliari, A Saviano, M L Serricchio, A A Dal Lago, M G Brizi, F Lanza, R Manfredi, A Gasbarrini, F Attili
Intraductal Papillary Mucinous Neoplasms (IPMNs) are the most common cystic tumors of the pancreas and are considered premalignant lesions. IPMNs are characterized by the papillary growth of the ductal epithelium with rich mucin production, which is responsible for cystic segmental or diffuse dilatation of the main pancreatic duct (MPD) and/or its branches. According to the different involvement of pancreatic duct system, IPMNs are divided into main duct type (MD-IPMN), branch duct type (BD-IPMN), and mixed type (MT-IPMN)...
June 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28633941/pancreatic-cyst-fluid-vascular-endothelial-growth-factor-a-and-carcinoembryonic-antigen-a-highly-accurate-test-for-the-diagnosis-of-serous-cystic-neoplasm
#17
Rosalie A Carr, Michele T Yip-Schneider, Scott Dolejs, Bradley A Hancock, Huangbing Wu, Milan Radovich, C Max Schmidt
BACKGROUND: Accurate differentiation of pancreatic cystic lesions is important for pancreatic cancer early detection and prevention as well as avoidance of unnecessary surgical intervention. Serous cystic neoplasms (SCN) have no malignant potential, but may mimic premalignant mucinous cystic lesions: mucinous cystic neoplasm (MCN) and intraductal papillary mucinous neoplasm (IPMN). We recently identified vascular endothelial growth factor (VEGF)-A as a novel pancreatic fluid biomarker for SCN...
May 18, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28590817/long-term-surveillance-and-timeline-of-progression-of-presumed-low-risk-intraductal-papillary-mucinous-neoplasms
#18
Maia Kayal, Lyndon Luk, Elizabeth M Hecht, Catherine Do, Beth A Schrope, John A Chabot, Tamas A Gonda
OBJECTIVE: The purpose of this study was to assess risk of progression and rate of growth of presumed low-risk branch duct intraductal papillary mucinous neoplasms surveyed for more than 4 years. MATERIALS AND METHODS: A keyword search of electronic medical charts was performed for the years 2001-2013. Cystic lesions that met the criteria for clinical branch duct intraductal papillary mucinous neoplasm, lacked baseline high-risk or worrisome features, and had more than 4 years of surveillance were included in this study...
August 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28588880/estimation-of-the-prevalence-of-intraductal-papillary-mucinous-neoplasm-of-the-pancreas-in-the-french-population-through-patients-waiting-for-liver-transplantation
#19
Lucie Laurent, Marie-Pierre Vullierme, Vinciane Rebours, Frédérique Maire, Olivia Hentic, Claire Francoz, François Durand, Philippe Ruszniewski, Philippe Lévy
BACKGROUND AND AIMS: Some studies have explored the prevalence of pancreatic cystic lesions (PCLs). Only one study based on magnetic resonance imaging (MRI) report examination focused specifically on intraductal papillary mucinous neoplasm (IPMN) in a European general population. The aim of this study was to evaluate the prevalence of IPMN in a population of patients who had MRI for a non-pancreatic disease. METHODS: We conducted a retrospective, single-center study...
June 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28573215/molecular-histologic-and-radiologic-findings-of-high-grade-invasive-adenocarcinoma-arising-in-oncocytic-subtype-of-intraductal-papillary-mucinous-neoplasm-a-case-report-and-review-of-literature
#20
Jared Shows, Christan Bartsch, Heather Carmichael, Irfan Qureshi, Barish Edil, Hubert Fenton
Background: We present a case of adenocarcinoma arising in the oncocytic subtype of intraductal papillary mucinous neoplasm (O-IPMN), with emphasis on the molecular findings in the adenocarcinoma component. Tissue microdissection and next-generation sequencing were performed using a 26 gene panel (AKT1, ALK, APC, BRAF, CDH1, CTNNB1, EGFR, ERBB2, FBXW7, FGFR2, FOXL2, GNAQ, GNAS, KIT, KRAS, MAP2K1, MET, MSH6, NRAS, PDGFRA, PIK3CA, PTEN, SMAD4, SRC, STK11, TP53) of cancer-related genes. Case Presentation: A 69-year-old Caucasian female presented with chest pain and was found to have findings consistent with acute pancreatitis...
2017: J Pancreat Cancer
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