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Autoimmune atrophic gastritis

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https://www.readbyqxmd.com/read/29720012/extranodal-rosai-dorfman-disease-with-mucosal-involvement-of-the-stomach-in-a-background-of-autoimmune-atrophic-gastritis
#1
Amanda Meindl, M Sambasiva Rao, Guang-Yu Yang
Rosai-Dorfman disease (RDD), or sinus histiocytosis with massive lymphadenopathy, has been described involving both lymph nodes and extranodal sites, but extranodal RDD rarely involves the gastrointestinal tract. Although the etiology is unclear, several risk factors have been shown to be highly associated with this disease process, including viral infection and immune alterations. In this article, we present a case of a 79-year-old male with a history of autoimmune atrophic gastritis and multiple carcinoid tumors of the stomach presenting with a new stomach mass...
May 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29705524/factors-related-to-gastric-neuroendocrine-tumors
#2
R Soto-Solís, A F Romano-Munive, K Santana de Anda, R Barreto-Zuñiga
INTRODUCTION AND AIMS: An association between long-term use of proton pump inhibitors and the development of gastric neuroendocrine tumors has been reported, but it is still a subject of debate. The aims of the present study were to determine the presence of this association in a Mexican population and to identify the risk factors for developing gastric neuroendocrine tumors. MATERIALS AND METHODS: A case-control study was conducted, in which the cases were patients with a histopathologic diagnosis of gastric neuroendocrine tumor and the controls were patients evaluated through upper endoscopy...
April 25, 2018: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/29587283/old-and-new-gut-hormone-gastrin-and-acid-suppressive-therapy
#3
Ken Haruma, Tomoari Kamada, Noriaki Manabe, Mitsuhiko Suehiro, Hirofumi Kawamoto, Akiko Shiotani
Gastrin acts physiologically as a gut hormone to stimulate acid secretion after meal and as a cell-growth factor of oxyntic mucosa. Increase in serum gastrin level happens under various conditions including Zollinger-Ellison syndrome, antral G cell hyperplasia, autoimmune gastritis, atrophic gastritis, renal failure, vagotomy, Helicobacter pylori infection and acid suppressive therapy. As acid suppressive therapy causes hypergastrinemia, the association between acid suppressive therapy and gastric neuroendocrine cell tumor (NET) has been discussed during the past 30 years...
2018: Digestion
https://www.readbyqxmd.com/read/29545439/unusual-association-between-erythema-nodosum-and-autoimmune-atrophic-gastritis
#4
Gisela Eugénio, Joao Tavares, Joana Fonseca Ferreira, Armando Malcata
We report a case of a 46-year-old woman with a history of autoimmune atrophic gastritis and recurrent erythema nodosum (EN). Laboratory results showed iron-deficiency anaemia, positive antiparietal cell antibodies and marginal deficiency of vitamin B12. Although EN was refractory to general measures (rest and non-steroidal anti-inflammatory drugs) and corticosteroid therapy, it was successfully treated with vitamin B12 supplementation.
March 15, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29361173/the-changing-face-of-noncardia-gastric-cancer-incidence-among-us-non-hispanic-whites
#5
William F Anderson, Charles S Rabkin, Natalie Turner, Joseph F Fraumeni, Philip S Rosenberg, M Constanza Camargo
Background: The initial step for noncardia gastric carcinogenesis is atrophic gastritis, driven by either Helicobacter pylori infection or autoimmunity. In recent decades, the prevalence rates of these two major causes declined and increased, respectively, with changes in Western lifestyles. We therefore assessed gastric cancer incidence trends for US race/ethnic groups, 1995-2013. Methods: Age-standardized rates (ASRs) from 45 North American Association of Central Cancer Tumor Registries were summarized by estimated annual percentage change (EAPC) and 95% confidence intervals (CIs)...
January 19, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29300536/autoimmune-polyendocrine-syndrome-type-2-in-patient-with-severe-allergic-asthma-treated-with-omalizumab
#6
Anna Rams, Marek Żółciński, Weronika Zastrzeżyńska, Stanisław Polański, Agnieszka Serafin, Joanna Wilańska, Jacek Musiał, Stanisława Bazan-Socha
Asthma therapy with monoclonal antibodies is a promising and effective approach for those with a severe and refractory type of disease. Although such a targeted therapy is considered to be safe, unusual complications may occur. We present a case of a 45 year-old female patient with severe allergic asthma and chronic spontaneous urticaria, who developed autoimmune polyendocrine syndrome type 2 (APS-2) after 26 months of omalizumab administration. The patient was diagnosed with primary adrenal insufficiency (Addison's disease) and Hashimoto's thyroiditis accompanied by autoimmune atrophic gastritis...
January 4, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29273468/systematic-gastric-biopsy-in-iron-deficiency-anaemia
#7
Hela Elloumi, Meriam Sabbah, Achraf Debbiche, Asma Ouakaa, Norsaf Bibani, Dorra Trad, Dalila Gargouri, Jamel Kharrat
BACKGROUND AND STUDY AIMS: Gastric biopsies are recommended in patients with iron deficiency anaemia to identify atrophic gastritis. However, in practice, only duodenal biopsies are routinely performed. The aim of our study was to determine the value of gastric biopsies in iron deficiency anaemia. PATIENTS AND METHODS: A prospective study including all patients referred for gastrointestinal endoscopy for iron deficiency anaemia from May 2008 to September 2014 was performed...
December 2017: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://www.readbyqxmd.com/read/29190137/high-risk-gastric-pathology-and-prevalent-autoimmune-diseases-in-patients-with-pernicious-anemia
#8
Jing W Hughes, Brian D Muegge, Garry S Tobin, Marina Litvin, Lulu Sun, Jose B Saenz, C Prakash Gyawali, Janet B McGill
OBJECTIVE: Pernicious anemia (PA) develops from atrophic gastritis due to autoimmune destruction of parietal cells and results in achlorhydria, vitamin B12 and iron deficiencies, anemia, neurologic deficits, and premalignant and malignant stomach lesions. We report the presentation, diagnosis and gastric complications of PA in patients from an endocrinology practice. METHODS: Thirty-four patients (31 female, 3 male) with PA who underwent esophagogastroduodenoscopy (EGD) or gastrectomy were identified...
November 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29095917/comparison-of-the-human-gastric-microbiota-in-hypochlorhydric-states-arising-as-a-result-of-helicobacter-pylori-induced-atrophic-gastritis-autoimmune-atrophic-gastritis-and-proton-pump-inhibitor-use
#9
COMPARATIVE STUDY
Bryony N Parsons, Umer Z Ijaz, Rosalinda D'Amore, Michael D Burkitt, Richard Eccles, Luca Lenzi, Carrie A Duckworth, Andrew R Moore, Laszlo Tiszlavicz, Andrea Varro, Neil Hall, D Mark Pritchard
Several conditions associated with reduced gastric acid secretion confer an altered risk of developing a gastric malignancy. Helicobacter pylori-induced atrophic gastritis predisposes to gastric adenocarcinoma, autoimmune atrophic gastritis is a precursor of type I gastric neuroendocrine tumours, whereas proton pump inhibitor (PPI) use does not affect stomach cancer risk. We hypothesised that each of these conditions was associated with specific alterations in the gastric microbiota and that this influenced subsequent tumour risk...
November 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29026595/time-trend-occurrence-of-duodenal-intraepithelial-lymphocytosis-and-celiac-disease-in-an-open-access-endoscopic-population
#10
Gloria Galli, Flaminia Purchiaroni, Edith Lahner, Maria Carlotta Sacchi, Emanuela Pilozzi, Vito Domenico Corleto, Emilio Di Giulio, Bruno Annibale
BACKGROUND: Duodenal intraepithelial lymphocytosis (DIL) is a histological finding characterized by the increase of intraepithelial CD3T-lymphocytes over the normal value without villous atrophy, mostly associated to coeliac disease (CD), Helicobacter pylori (Hp) gastritis and autoimmune diseases. OBJECTIVE: To assess the occurrence of DIL, CD and Hp gastritis in an endoscopic population over a 13 year period. METHODS: From 2003 to 2015 we included adult patients who consecutively underwent oesophago-gastro-duodenoscopy (OGD) with duodenal biopsies assessing the overall and annual occurrence of DIL and CD and the prevalence of Hp gastritis...
October 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28972879/challenging-clinical-presentations-of-pernicious-anemia
#11
Thein Hlaing Oo, Cristhiam Mauricio Rojas-Hernandez
Pernicious anemia (PA) is an autoimmune disease of multifactorial etiologies characterized by autoimmune chronic atrophic gastritis, cobalamin deficiency (CD) due to defective absorption of dietary cobalamin from the terminal ileum, and by the presence of intrinsic factor and parietal cell antibodies. PA is a very common cause of CD-related anemia worldwide. Despite advances in the understanding molecular biology and pathophysiology of PA, the diagnosis of PA remains challenging in many circumstances for many clinicians because of its diverse clinical manifestations and the limitations of currently available diagnostic tools...
September 2017: Discovery Medicine
https://www.readbyqxmd.com/read/28970729/patients-with-inflammatory-bowel-disease-have-increased-risk-of-autoimmune-and-inflammatory-diseases
#12
Morten L Halling, Jens Kjeldsen, Torben Knudsen, Jan Nielsen, Lars Koch Hansen
AIM: To investigate whether immune mediated diseases (IMD) are more frequent in patients with inflammatory bowel disease (IBD). METHODS: In this population based registry study, a total of 47325 patients with IBD were alive and registered in the Danish National Patient Registry on December 16, 2013. Controls were randomly selected from the Danish Civil Registration System (CRS) and matched for sex, age, and municipality. We used ICD 10 codes to identify the diagnoses of the included patients...
September 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28948030/a-case-of-pernicious-anemia-requiring-differential-diagnosis-of-autoimmune-hemolytic-anemia-complication
#13
Saki Todo, Kohei Okamoto, Takeshi Sugimoto, Toshimasa Takahashi, Yasushi Nakagawa, Takashi Arai, Katsuhito Nishiyama, Kenta Hara, Yoshiro Yasutomo, Koichi Yokono
An 80-year-old female was admitted to our hospital due to malaise. The initial diagnosis on admission was pernicious anemia (PA), Hashimoto thyroiditis and autoimmune atrophic gastritis. Autoimmune hemolytic anemia was suspected because direct antiglobulin test (DAT) was positive. Treatment with vitamin B12 improved anemia, with the disappearance of hemolysis. In some cases, PA patients with positive DAT may have hemolysis without the involvement of the autoimmune mechanism. Therefore, it is important to carefully assess PA patients with hemolysis and positive DAT for the prevention of unnecessary administration of steroid therapy...
September 2017: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/28929353/anti-parietal-cell-antibodies-in-patients-with-autoimmune-thyroid-diseases
#14
S R R Utiyama, R S De Bem, T L Skare, G A De Carvalho, L M Teixeira, M Bertolazo, S O Ioshii, R Nisihara
BACKGROUND: Autoimmune thyroid disease (ATD) patients may have a higher prevalence of anti-parietal cell antibodies (APCA) than normal population. OBJECTIVE: To study the prevalence of APCA in a cohort of ATD patients to know its association with patient's clinical profile and gastrointestinal complaints. METHODS: APCA was sought for by indirect immunofluorescence test in 243 ATD patients: 136 (55.9%) with Graves' disease and 107 (44.0%) with Hashimoto's thyroiditis...
May 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28733178/clinical-usefulness-of-serum-antibodies-as-biomarkers-of-gastrointestinal-and-liver-diseases
#15
REVIEW
Antonio Di Sabatino, Federico Biagi, Marco Lenzi, Luca Frulloni, Marco Vincenzo Lenti, Paolo Giuffrida, Gino Roberto Corazza
The progressively growing knowledge of the pathophysiology of a number of immune-mediated gastrointestinal and liver disorders, including autoimmune atrophic gastritis, coeliac disease, autoimmune enteropathy, inflammatory bowel disease, autoimmune hepatitis, primary sclerosing cholangitis, primary biliary cholangitis and autoimmune pancreatitis, together with the improvement of their detection methods have increased the diagnostic power of serum antibodies. In some cases - coeliac disease and autoimmune atrophic gastritis - they have radically changed gastroenterologists' diagnostic ability, while in others - autoimmune hepatitis, inflammatory bowel disease and autoimmune pancreatitis - their diagnostic performance is still inadequate...
September 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28711333/b12-deficiency-leading-to-marked-poikilocytosis-versus-true-schistocytosis-a-pernicious-problem
#16
James A Hall, James Mason, Julia Choi, Mark Holguin
Severe vitamin B12 deficiency is caused most commonly by autoimmune atrophic gastritis leading to loss of intrinsic factor. Vitamin B12 deficiency leading to megaloblastic anemia and demyelinating central nervous system disease is well known; however, a rare presentation of B12 deficiency described as pseudothrombotic microangiopathy is not well known. This complication presents with signs of mechanical hemolysis, elevated lactate dehydrogenase (LDH), thrombocytopenia, and a low reticulocyte count, which can be incorrectly diagnosed as thrombotic thrombocytopenic purpura and managed incorrectly...
June 20, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28676841/an-in-vitro-model-of-gastric-inflammation-and-treatment-with-cobalamin
#17
T R Elliott, A L Guildford
Pernicious anaemia (PA) is an autoimmune condition where antibodies target intrinsic factor and parietal cells, reducing the patient's ability to absorb cobalamin promoting atrophic gastritis. Treatment guidelines are based on excretion data of hydroxocobalamin from healthy individuals obtained 50 years ago. This manuscript describes the use of phorbol 12-myristate 13-acetate (PMA) to stimulate low grade inflammation in an epithelial colorectal cell line to assess the efficacy of methylcobalamin and hydroxocobalamin...
2017: International Journal of Inflammation
https://www.readbyqxmd.com/read/28487082/esophageal-chemical-clearance-and-baseline-impedance-values-in-patients-with-chronic-autoimmune-atrophic-gastritis-and-gastro-esophageal-reflux-disease
#18
Andrea Tenca, Nicola de Bortoli, Aurelio Mauro, Marzio Frazzoni, Edoardo Savarino, Sara Massironi, Salvatore Russo, Lorenzo Bertani, Santino Marchi, Roberto Penagini
BACKGROUND: The factors influencing new markers of gastro-esophageal reflux disease detected by impedance-pH monitoring - mean nocturnal baseline impedance (MNBI) and post-reflux swallow-induced peristaltic wave (PSPW) index - need to be evaluated. AIM: To compare endoscopy-negative heartburn with chronic autoimmune atrophic gastritis (CAAG). MATERIALS AND METHODS: 24 patients with CAAG, 25 with non-erosive reflux disease (NERD) and 25 with functional heartburn (FH) were included...
April 13, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28465717/protein-signature-characterizing-helicobacter-pylori-strains-of-patients-with-autoimmune-atrophic-gastritis-duodenal-ulcer-and-gastric-cancer
#19
Valli De Re, Ombretta Repetto, Stefania Zanussi, Mariateresa Casarotto, Laura Caggiari, Vincenzo Canzonieri, Renato Cannizzaro
BACKGROUND: Helicobacter pylori (H. pylori) represents a key factor in the etiology of autoimmune atrophic gastritis (AAG), duodenal ulcer (DU) and gastric cancer (GC). The aim of this study was to characterize the differential protein expression of H. pylori isolated from gastric biopsies of patients affected by either AAG, DU or GC. METHODS: The H. pylori strains were isolated from endoscopic biopsies from the stomach of patients with gastric disease. Protein profiles of H...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28405320/distinct-metaplastic-and-inflammatory-phenotypes-in-autoimmune-and-adenocarcinoma-associated-chronic-atrophic-gastritis
#20
Sangho Jeong, Eunyoung Choi, Christine P Petersen, Joseph T Roland, Alessandro Federico, Rossana Ippolito, Francesco P D'Armiento, Gerardo Nardone, Osamu Nagano, Hideyuki Saya, Marco Romano, James R Goldenring
BACKGROUND: Autoimmune gastritis (AIG) and adenocarcinoma-associated chronic atrophic gastritis (CAG) are both associated with oxyntic atrophy, but AIG patients demonstrate an increased risk of carcinoid tumors rather than the elevated risk of adenocarcinoma observed with CAG. We therefore sought to compare the characteristics of the metaplastic mucosa in AIG and CAG patients. METHODS: We examined markers for metaplasia (spasmolytic polypeptide expressing metaplasia (SPEM) and intestinal metaplasia) as well as proliferation (Ki67) and immune cell populations (neutrophils, macrophages, and eosinophils) in gastric sections from 16 female patients with autoimmune thyroiditis and AIG and 17 patients with CAG associated with gastric adenocarcinoma...
February 2017: United European Gastroenterology Journal
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