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Autoimmune atrophic gastritis

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https://www.readbyqxmd.com/read/27793414/antigastric-parietal-cell-and-antithyroid-autoantibodies-in-patients-with-recurrent-aphthous-stomatitis
#1
Yang-Che Wu, Yu-Hsueh Wu, Yi-Ping Wang, Julia Yu-Fong Chang, Hsin-Ming Chen, Andy Sun
BACKGROUND/PURPOSE: Anti-gastric parietal cell antibody (GPCA), anti-thyroglobulin antibody (TGA), and anti-thyroid microsomal antibody (TMA) have not yet been reported in patients with recurrent aphthous stomatitis (RAS). This study mainly assessed the frequencies of the presence of serum GPCA, TGA, and TMA in different types of RAS patients. METHODS: Serum GPCA, TGA, and TMA levels were measured in 355 RAS patients of different subtypes and in 355 age- and sex-matched healthy control individuals...
October 25, 2016: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/27767239/morphology-and-genetics-of-pyloric-gland-adenomas-in-familial-adenomatous-polyposis
#2
Wenzel M Hackeng, Elizabeth A Montgomery, Francis M Giardiello, Aatur D Singhi, Marija Debeljak, James R Eshleman, Michael Vieth, G Johan A Offerhaus, Laura D Wood, Lodewijk A A Brosens
BACKGROUND: Gastric pyloric gland adenomas (PGAs) are rare epithelial polyps that are more commonly found in autoimmune atrophic gastritis and familial adenomatous polyposis. Little is known about the morphology and genetics of PGAs in familial adenomatous polyposis. AIMS: PGAs in familial adenomatous polyposis are studied morphologically and genetically. Findings in FAP associated PGAs are compared to sporadic PGAs and related lesions such as oxyntic gland adenoma (OGA) to increase our understanding of these rare polyps...
October 21, 2016: Histopathology
https://www.readbyqxmd.com/read/27729029/malignant-transformation-of-a-gastric-hyperplastic-polyp-in-a-context-of-helicobacter-pylori-negative-autoimmune-gastritis-a-case-report
#3
Kenichi Yamanaka, Hiroyuki Miyatani, Yukio Yoshida, Takehiro Ishii, Shinichi Asabe, Osamu Takada, Mitsuhiro Nokubi, Hirosato Mashima
BACKGROUND: Gastric foveolar hyperplastic polyps (GFHPs) are common findings in clinical practice. GFHPs commonly arise in a background of chronic atrophic gastritis, including autoimmune gastritis (type A gastritis), and have a potential risk of malignant transformation. CASE PRESENTATION: In 2005, a 55-year-old Japanese woman underwent upper endoscopy at another hospital and was found to have a pedunculated polyp (10 mm in diameter) on the greater curvature of the lower gastric body...
October 12, 2016: BMC Gastroenterology
https://www.readbyqxmd.com/read/27704617/netazepide-a-gastrin-cck2-receptor-antagonist-can-eradicate-gastric-neuroendocrine-tumours-in-patients-with-autoimmune-chronic-atrophic-gastritis
#4
Malcolm Boyce, Andrew R Moore, Liv Sagatun, Bryony N Parsons, Andrea Varro, Fiona Campbell, Reidar Fossmark, Helge L Waldum, David M Pritchard
AIMS: Netazepide, a gastrin/CCK2 receptor antagonist, once daily for 12 weeks reduced the number of tumours and size of the largest one in 16 patients with autoimmune chronic atrophic gastritis (CAG), achlorhydria, hypergastrinaemia and multiple gastric neuroendocrine tumours (type 1 gastric NETs), and normalised circulating chromogranin A (CgA) produced by enterochromaffin-like cells, the source of the tumours. The aim was to assess whether longer-term netazepide treatment can eradicate type 1 gastric NETs...
October 4, 2016: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27599778/antigastric-parietal-cell-and-antithyroid-autoantibodies-in-patients-with-desquamative-gingivitis
#5
Julia Yu-Fong Chang, Chun-Pin Chiang, Yi-Ping Wang, Yang-Che Wu, Hsin-Ming Chen, Andy Sun
BACKGROUND: Desquamative gingivitis (DG) is principally associated with erosive oral lichen planus (EOLP), mucous membrane pemphigoid (MMP), and pemphigus vulgaris (PV). METHODS: Serum autoantibodies including antigastric parietal cell antibody (GPCA), antithyroglobulin antibody (TGA), and antithyroid microsomal antibody (TMA) were measured in 500 patients with DG, 287 EOLP without DG (EOLP/DG(-) ) patients, and 100 healthy control subjects. RESULTS: The 500 patients with DG were diagnosed as having EOLP in 455 (91%), PV in 40 (8%), and MMP in five (1%) patients...
September 7, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27570419/management-of-gastric-and-duodenal-neuroendocrine-tumors
#6
REVIEW
Yuichi Sato, Satoru Hashimoto, Ken-Ichi Mizuno, Manabu Takeuchi, Shuji Terai
Gastrointestinal neuroendocrine tumors (GI-NETs) are rare neoplasms, like all NETs. However, the incidence of GI-NETS has been increasing in recent years. Gastric NETs (G-NETs) and duodenal NETs (D-NETs) are the common types of upper GI-NETs based on tumor location. G-NETs are classified into three distinct subgroups: type I, II, and III. Type I G-NETs, which are the most common subtype (70%-80% of all G-NETs), are associated with chronic atrophic gastritis, including autoimmune gastritis and Helicobacter pylori associated atrophic gastritis...
August 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27538411/pathophysiology-and-laboratory-diagnosis-of-pernicious-anemia
#7
Ban-Hock Toh
Pernicious anemia is the hematologic manifestation of chronic atrophic gastritis affecting the corpus of the stomach that denudes the gastric mucosa of gastric parietal cells. Asymptomatic autoimmune gastritis, a chronic inflammatory disease of the gastric mucosa, precedes the onset of corpus atrophy by 10-20 years. The gastritis arises from activation of pathologic Th1 CD4 T cells to gastric H/K ATPase that is normally resident on gastric mucosal secretory membranes. The onset of autoimmune gastritis is marked by circulating parietal cell antibody to gastric H/K ATPase...
August 18, 2016: Immunologic Research
https://www.readbyqxmd.com/read/27441820/pepsinogens-to-distinguish-patients-with-gastric-intestinal-metaplasia-and-helicobacter-pylori-infection-among-populations-at-risk-for-gastric-cancer
#8
Valli De Re, Enrico Orzes, Vincenzo Canzonieri, Stefania Maiero, Mara Fornasarig, Lara Alessandrini, Silvia Cervo, Agostino Steffan, Giorgio Zanette, Cinzia Mazzon, Paolo De Paoli, Renato Cannizzaro
OBJECTIVES: The objectives of this study were to investigate the serum pepsinogen test for the prediction of OLGIM (Operative Link on Gastric Intestinal Metaplasia Assessment) stages in first-degree relatives (FDR-GC) of patients with gastric cancer (GC) and autoimmune chronic atrophic gastritis (ACAG). METHODS: In 67 consecutive patients with ACAG, 82 FDR-GC, and 53 controls (CTRL) without gastric disease (confirmed by biopsy), serum levels of pepsinogen 1 (PG1), pepsinogen 2 (PG2), G17, and the PG1/2 ratio were assessed by enzyme-linked immunosorbent assay kit...
July 21, 2016: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/27323780/gastrin-induced-mir-222-promotes-gastric-tumor-development-by-suppressing-p27kip1
#9
Katie A Lloyd, Andrew R Moore, Bryony N Parsons, Adrian O'Hara, Malcolm Boyce, Graham J Dockray, Andrea Varro, D Mark Pritchard
BACKGROUND AND AIMS: Elevated circulating concentrations of the hormone gastrin contribute to the development of gastric adenocarcinoma and types-1 and 2 gastric neuroendocrine tumors (NETs). MicroRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally regulate proteins which in turn influence various biological processes. We hypothesised that gastrin induces the expression of specific gastric miRNAs within CCK2 receptor (CCK2R) expressing cells and that these mediate functionally important actions of gastrin...
June 14, 2016: Oncotarget
https://www.readbyqxmd.com/read/27306997/sporadic-gastric-well-differentiated-neuroendocrine-tumors-have-a-higher-ki-67-proliferative-index
#10
Hee Eun Lee, Taofic Mounajjed, Lori A Erickson, Tsung-Teh Wu
Well-differentiated neuroendocrine tumor (WDNET) of the stomach can arise in three distinct clinical settings: (1) in association with autoimmune atrophic gastritis, (2) in association with multiple neuroendocrine neoplasia type I (MEN I) or Zollinger-Ellison syndrome (ZES), or (3) sporadic. The Ki-67 proliferative index (PI) in gastric WDNETs in these three distinct clinical settings has not been evaluated in detail. Forty-five gastric WNETs underwent polypectomy (n = 4), endoscopic mucosal resection (n = 12), and surgical resection (n = 29) between 1994 and 2015 were included...
September 2016: Endocrine Pathology
https://www.readbyqxmd.com/read/27222404/prevalence-of-vitamin-b-12-deficiency-among-patients-with-thyroid-dysfunction
#11
REVIEW
Aryn B Collins, Roman Pawlak
Due to the non-specificity of symptoms and possibly severe consequences of untreated vitamin B-12 deficiency, screening is important for at-risk patients to ensure the prompt delivery of treatment. In this review, studies assessing the prevalence of vitamin B-12 deficiency in thyroid dysfunction are evaluated to determine whether regular vitamin B-12 screening is necessary. A literature search was conducted using multiple electronic databases. Only original studies assessing the prevalence of vitamin B-12 deficiency in thyroid dysfunction that reported their findings as percentages of the sample were eligible for inclusion...
2016: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27085391/polyautoimmunity-in-autoimmune-gastritis
#12
Çağdaş Kalkan, Irfan Soykan
OBJECTIVES: Autoimmune gastritis may be associated with other organ-specific autoimmune disorders, but the prevalence of this association is not entirely quantified. The aims of this study were to investigate the prevalence of autoimmune disorders and evaluate the factors that might affect this association in patients with autoimmune gastritis. METHODS: A total of 320 patients with autoimmune gastritis were retrospectively studied and data on concomitant autoimmune diseases, serum gastrin and chromogranin A levels, anti-Hp IgG, antiparietal cell antibodies, presence of enterochromaffin-like cell hyperplasia and gastric atrophy were gathered for each patient and associations between autoimmune gastritis and studied parameters were explored through descriptive statistics and logistic regression analysis...
June 2016: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/27020497/the-pathological-findings-seen-in-laparoscopic-sleeve-gastrectomies-for-weight-loss
#13
Gregory C Miller, Andrew S Reid, Ian S Brown
Sleeve gastrectomy specimens are increasingly common surgical specimens received for examination following bariatric surgery for weight loss. The spectrum of pathological changes seen in these cases is not well documented. Retrospective examination was undertaken of 1463 consecutive sleeve gastrectomy specimens received at Envoi Specialist Pathologists. Most cases showed no pathological changes (80.2%). The most common changes seen were non-specific, non-Helicobacter associated chronic gastritis (7.2%), Helicobacter associated gastritis (6...
April 2016: Pathology
https://www.readbyqxmd.com/read/27018160/an-unusual-presentation-of-pseudothrombotic-microangiopathy-in-a-patient-with-autoimmune-atrophic-gastritis
#14
Alexandre Malek, Roy Nasnas
Introduction. We hereby describe the case of a young female patient who presented with pseudothrombotic microangiopathy, as well as pancytopenia accompanied by autoimmune atrophic gastritis. Case Presentation. A 36-year-old Caucasian woman presented to the emergency department with fatigue and dyspnea on minimal exertion. Physical examination was unremarkable except for pallor and noninjected conjunctiva. Laboratory tests revealed high LDH and low hemoglobin, white blood cells, platelets, and haptoglobin. The peripheral blood smear showed schistocytes suggestive of pseudothrombotic microangiopathy...
2016: Case Reports in Hematology
https://www.readbyqxmd.com/read/26965518/reversible-normalisation-of-serum-tsh-levels-in-patients-with-autoimmune-atrophic-gastritis-who-received-l-t4-in-tablet-form-after-switching-to-an-oral-liquid-formulation-a-case-series
#15
Poupak Fallahi, Silvia Martina Ferrari, Ilaria Ruffilli, Alessando Antonelli
BACKGROUND: L-thyroxine (L-T4) malabsorption is a potential concern in patients with autoimmune atrophic gastritis. METHODS: We evaluated five patients with autoimmune gastritis, who showed high serum thyrotropin (TSH) levels (in the hypothyroid range) while in therapy with L-T4 in tablet. All patients were switched to receive an oral L-T4 liquid formulation maintaining the same dosage. RESULTS: In all patients who received L-T4 in tablet form after switching to an oral liquid formulation with the same L-T4 dosage, TSH circulating levels were normalized...
2016: BMC Gastroenterology
https://www.readbyqxmd.com/read/26935626/-iron-refractory-iron-deficiency-anemia
#16
Hiroshi Kawabata
The major causes of iron deficiency anemia (IDA) include iron loss due to bleeding, increased iron requirements, and decreased iron absorption by the intestine. The most common cause of IDA in Japanese women is iron loss during menstruation. Autoimmune atrophic gastritis and Helicobacter pylori infection can also cause IDA by reducing intestinal iron absorption. In addition to these common etiologies, germline mutations of TMPRSS6 can cause iron-refractory IDA (IRIDA). TMPRSS6 encodes matriptase-2, a membrane-bound serine protease primarily expressed in the liver...
February 2016: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/26928404/association-of-autoimmune-thyroid-diseases-chronic-atrophic-gastritis-and-gastric-carcinoid-experience-from-a-single-institution
#17
C Castoro, R Le Moli, M L Arpi, M Tavarelli, G Sapuppo, L Frittitta, S Squatrito, G Pellegriti
PURPOSE: Autoimmune polyendocrine syndromes (APS) type III are characterized by the association of autoimmune thyroid disease (ATD) with other autoimmune diseases such as diabetes, alopecia, pernicious anemia, vitiligo and chronic atrophic gastritis. A strong association between ATD and atrophic gastritis (AG) has been demonstrated. Moreover 10 % of patients affected by AG have a predisposition to develop gastric carcinoid and adenocarcinoma as a result of chronic hypergastrinemia caused by achlorhydria and subsequent ELC cells neoplastic transformation...
July 2016: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/26918709/anti-parietal-cell-antibodies-diagnostic-significance
#18
Ewa Rusak, Agata Chobot, Agnieszka Krzywicka, Janet Wenzlau
Anti-parietal cell antibodies (APCA) are an advantageous tool for screening for autoimmune atrophic gastritis (AAG) and pernicious anemia (PA). The target for APCA is the H+/K+ ATP-ase. It has been demonstrated, that APCA target both, the alpha, and beta subunits of the proton pump, although the major antigen is the alpha subunit. Circulating serum APCA can be detected by means of immunofluorescence, enzyme-linked immunosorbent assay - currently the most commonly used method, and radioimmunoprecipitation assay (RIA) - the 4A subunit has been optimized as a molecular-specific antigen probe...
January 13, 2016: Advances in Medical Sciences
https://www.readbyqxmd.com/read/26701848/let-7c-down-regulation-in-helicobacter-pylori-related-gastric-carcinogenesis
#19
Matteo Fassan, Deborah Saraggi, Laura Balsamo, Luciano Cascione, Carlo Castoro, Irene Coati, Marina De Bernard, Fabio Farinati, Vincenza Guzzardo, Nicola Valeri, Carlo Federico Zambon, Massimo Rugge
Aberrant let-7c microRNA (miRNA) expression has been observed in Helicobacter pylori-related gastric cancer (GC) but fragmentary information is available on the let-7c dysregulation occurring with each phenotypic change involved in gastric carcinogenesis. Let-7c expression was assessed (qRT-PCR) in a series of 175 gastric biopsy samples representative of the whole spectrum of phenotypic changes involved in H. pylori-related gastric oncogenesis including: i) normal gastric mucosa, as obtained from dyspeptic controls (40 biopsy samples); ii) non-atrophic gastritis (40 samples); iii) atrophic-metaplastic gastritis (35 samples); iv) intra-epithelial neoplasia (30 samples); v) GC (30 samples)...
January 26, 2016: Oncotarget
https://www.readbyqxmd.com/read/26655140/gastric-calcifying-fibrous-tumor-a-case-of-suspected-immunoglobulin-g4-related-gastric-disease
#20
Hejun Zhang, Zhu Jin, Shigang Ding
Gastrointestinal lesions resulting from immunoglobulin G4-related disease are classified into two types: One is a gastrointestinal lesion showing marked thickening of the wall, and the other is an IgG4-related pseudotumor. We report the case of a woman with gastric calcifying fibrous tumor undergoing endoscopic resection that contained 62 IgG4+ plasma cells per high-power field and an IgG4-to-IgG ratio of 41% in lesional plasma cells, which shared clinical and histopathological features associated with gastric IgG4-related pseudotumor...
November 2015: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
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