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Atrophic gastritis

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https://www.readbyqxmd.com/read/29666399/genotype-b-of-killer-cell-immunoglobulin-like-receptor-is-related-with-gastric-cancer-lesions
#1
Eric G Hernandez, Oswaldo Partida-Rodriguez, Margarita Camorlinga-Ponce, Miriam Nieves-Ramirez, Irma Ramos-Vega, Javier Torres, Martha Perez-Rodriguez
NK cells are important in innate immunity for their capacity to kill infected or cancer cells. The killer cell immunoglobulin-like receptors (KIR) are a family of polymorphic genes with inhibitory and activating functions. The main driving force for gastric cancer (GC) development is a chronic response, which causes an increase of NK cells in the gastric mucosa. The aim of this work was to study polymorphisms in KIR genes in patients with either GC or non-atrophic gastritis (NAG). We studied 242 patients (130 with NAG and 112 with GC) and contrasted with 146 asymptomatic individuals...
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29665437/multiplex-serology-of-helicobacter-pylori-antigens-in-detection-of-current-infection-and-atrophic-gastritis-a-simple-and-cost-efficient-method
#2
Ebrahim Shafaie, Samaneh Saberi, Maryam Esmaeili, Zeynab Karimi, Saeed Najafi, Mohammad Tashakoripoor, Afshin Abdirad, Mahmoud Eshagh Hosseini, Mohammad Ali Mohagheghi, Vahid Khalaj, Marjan Mohammadi
INTRODUCTION: Helicobacter pylori express a large array of antigens, each of which is duly responsible for successful colonization and pathogenesis. Here, we have studied host serum antibody responses to four of its immunodominant antigens in association with the infection status and the resulting clinical outcomes. METHODS: For this purpose, four individual H. pylori proteins (UreB, CagA, Tip-α and HP0175) were produced in recombinant forms. Serum antibody responses of 246 (75 GC and 171 NUD) patients, against the above antigens, were evaluated by multiplex immunoblotting...
April 14, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29663251/histopathological-findings-in-morbid-obese-patients-undergoing-laparoscopic-sleeve-gastrectomy-does-h-pylori-infection-effective-on-pathological-changes
#3
Ramazan İlyas Öner, Sabri Özdaş
AıM: To determine the prevalence of histopathological findings requiring clinical follow-up in morbidly obese patients undergoing laparoscopic sleeve gastrectomy (LSG) and evaluate the relationship between these findings and Helicobacter pylori as well as to add more data to the published literature in this regard. MATERıAL AND METHODS: Overall, 161 morbidly obese patients with body mass index (BMI) > 40 kg/m2 who underwent LSG between May 1, 2014 and May 31, 2017 were retrospectively included in the study...
April 16, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29658052/reduced-%C3%AE-glcnac-glycosylation-on-gastric-gland-mucin-is-a-biomarker-of-malignant-potential-for-gastric-cancer-barrett-s-adenocarcinoma-and-pancreatic-cancer
#4
REVIEW
Kazuhiro Yamanoi, Jun Nakayama
Gastric gland mucin secreted from pyloric gland cells, mucous neck cells, and cardiac gland cells of the gastric mucosa harbors unique O-glycans carrying terminal α1,4-linked N-acetylglucosamine residues (αGlcNAc), which are primarily attached to the scaffold mucin core protein MUC6. αGlcNAc acts as an antibiotic against Helicobacter pylori (H. pylori), a microbe causing gastric cancer. In addition, mice deficient in A4gnt, which encodes the enzyme α1,4-N-acetylglucosaminyltransferase (α4GnT) that catalyzes αGlcNAc biosynthesis, spontaneously develop gastric differentiated-type adenocarcinoma, even if not infected by H...
April 16, 2018: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/29656498/helicobacter-pylori-infection-induced-h3ser10-phosphorylation-in-stepwise-gastric-carcinogenesis-and-its-clinical-implications
#5
Tao-Tao Yang, Na Cao, Hai-Hui Zhang, Jian-Bo Wei, Xiao-Xia Song, Dong-Min Yi, Shuai-Heng Chao, Li-Da Zhang, Ling-Fei Kong, Shuang-Yin Han, Yu-Xiu Yang, Song-Ze Ding
BACKGROUND: Our previous works have demonstrated that Helicobacter pylori (Hp) infection can alter histone H3 serine 10 phosphorylation status in gastric epithelial cells. However, whether Helicobacter pylori-induced histone H3 serine 10 phosphorylation participates in gastric carcinogenesis is unknown. We investigate the expression of histone H3 serine 10 phosphorylation in various stages of gastric disease and explore its clinical implication. MATERIALS AND METHODS: Stomach biopsy samples from 129 patients were collected and stained with histone H3 serine 10 phosphorylation, Ki67, and Helicobacter pylori by immunohistochemistry staining, expressed as labeling index...
April 15, 2018: Helicobacter
https://www.readbyqxmd.com/read/29629520/training-effect-on-the-inter-observer-agreement-in-endoscopic-diagnosis-and-grading-of-atrophic-gastritis-according-to-level-of-endoscopic-experience
#6
Eun Hyo Jin, Su Jin Chung, Joo Hyun Lim, Goh Eun Chung, Changhyun Lee, Jong In Yang, Joo Sung Kim
BACKGROUND: Endoscopic diagnosis of atrophic gastritis can contribute to risk stratification and thereby tailored screening for gastric cancer. We aimed to evaluate the effect of training on inter-observer agreement in diagnosis and grading of endoscopic atrophic gastritis (EAG) according to the level of endoscopists' experience. METHODS: Twelve endoscopists (six less-experienced and six experienced) participated in this prospective study. The training session consisted of 1) four interventions with two-week intervals, and 2) a follow-up period (two follow-up assessments without feedback)...
April 9, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29625086/tr1-responses-are-elevated-in-asymptomatic-h-pylori-infected-individuals-and-are-functionally-impaired-in-h-pylori-gastric-cancer-patients
#7
Zongchang Song, Tongxia Zhang, Guang Li, Ying Tang, Yan Luo, Genhua Yu
Gastric cancer is one of the most lethal malignancies worldwide. Chronic Helicobacter pylori (H. pylori) infection can induce an inflammatory response that promotes atrophic gastritis, a preceding event to cancer development. The type 1 regulatory T (Tr1) cells have recently emerged as a critical participant in maintaining self-tolerance. In this study, we examined Tr1 cells in H. pylori infection and gastric cancer development. While H. pylori-uninfected (uninfected) subjects presented low Tr1 frequency in the peripheral blood, H...
April 3, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29599609/correlation-between-serum-vitamin-b12-level-and-peripheral-neuropathy-in-atrophic-gastritis
#8
Guo-Tao Yang, Hong-Ying Zhao, Yu Kong, Ning-Ning Sun, Ai-Qin Dong
AIM: To explore the correlation between serum vitamin B12 level and peripheral neuropathy in patients with chronic atrophic gastritis (CAG). METHODS: A total of 593 patients diagnosed with chronic gastritis by gastroscopy and pathological examination from September 2013 to September 2016 were selected for this study. The age of these patients ranged within 18- to 75-years-old. Blood pressure, height and weight were measured in each patient, and the body mass index value was calculated...
March 28, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29596454/classification-of-atrophic-mucosal-patterns-on-blue-laser-imaging-for-endoscopic-diagnosis-of-helicobacter-pylori-related-gastritis-a-retrospective-observational-study
#9
Yoshiyuki Nishikawa, Yoshio Ikeda, Hidehiro Murakami, Shin-Ichiro Hori, Kaori Hino, Chise Sasaki, Megumi Nishikawa
BACKGROUND: Atrophic gastritis can be classified according to characteristic mucosal patterns observed by Blue LASER Imaging (BLI) in a medium-range to distant view. AIMS: To facilitate the endoscopic diagnosis of Helicobacter pylori (HP)-related gastritis, we investigated whether atrophic mucosal patterns correlated with HP infection based on the image interpretations of three endoscopists blinded to clinical features. METHODS: This study included 441 patients diagnosed as having atrophic gastritis by upper gastrointestinal endoscopy at Nishikawa Gastrointestinal Clinic between April 1, 2015 and March 31, 2016...
2018: PloS One
https://www.readbyqxmd.com/read/29587295/helicobacter-pylori-eradication-therapy-ameliorates-latent-digestive-symptoms-in-chronic-atrophic-gastritis
#10
Shinya Yamada, Naoya Tomatsuri, Takumi Kawakami, Yoshikazu Nakatsugawa, Takeshi Nishimura, Hideki Fujii, Hideki Sato, Yusuke Okuyama, Hiroyuki Kimura, Norimasa Yoshida
BACKGROUND/AIMS: This study investigated the effect of Helicobacter pylori eradication therapy on latent digestive symptoms in chronic atrophic gastritis. METHODS: We enrolled 650 health checkup patients who underwent eradication therapy for chronic gastritis and completed a self-report questionnaire before and after the treatment between January 2014 and December 2016 at the Japanese Red Cross Society Kyoto Daiichi Hospital. RESULTS: H. pylori eradication therapy for chronic atrophic gastritis improved latent digestive symptoms, including both the acid reflux and dyspepsia components in the frequency scale for the symptoms of gastroesophageal reflux disease (FSSG) scores...
March 27, 2018: Digestion
https://www.readbyqxmd.com/read/29587283/old-and-new-gut-hormone-gastrin-and-acid-suppressive-therapy
#11
Ken Haruma, Tomoari Kamada, Noriaki Manabe, Mitsuhiko Suehiro, Hirofumi Kawamoto, Akiko Shiotani
Gastrin acts physiologically as a gut hormone to stimulate acid secretion after meal and as a cell-growth factor of oxyntic mucosa. Increase in serum gastrin level happens under various conditions including Zollinger-Ellison syndrome, antral G cell hyperplasia, autoimmune gastritis, atrophic gastritis, renal failure, vagotomy, Helicobacter pylori infection and acid suppressive therapy. As acid suppressive therapy causes hypergastrinemia, the association between acid suppressive therapy and gastric neuroendocrine cell tumor (NET) has been discussed during the past 30 years...
March 27, 2018: Digestion
https://www.readbyqxmd.com/read/29565647/hierarchical-and-complex-system-entropy-clustering-analysis-based-validation-for-traditional-chinese-medicine-syndrome-patterns-of-chronic-atrophic-gastritis
#12
Yin Zhang, Yue Liu, Yannan Li, Xia Zhao, Lin Zhuo, Ajian Zhou, Li Zhang, Zeqi Su, Cen Chen, Shiyu Du, Daming Liu, Xia Ding
OBJECTIVES: Chronic atrophic gastritis (CAG) is the precancerous stage of gastric carcinoma. Traditional Chinese Medicine (TCM) has been widely used in treating CAG. This study aimed to reveal core pathogenesis of CAG by validating the TCM syndrome patterns and provide evidence for optimization of treatment strategies. DESIGN: This is a cross-sectional study conducted in 4 hospitals in China. Hierarchical clustering analysis (HCA) and complex system entropy clustering analysis (CSECA) were performed, respectively, to achieve syndrome pattern validation...
March 22, 2018: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/29545439/unusual-association-between-erythema-nodosum-and-autoimmune-atrophic-gastritis
#13
Gisela Eugénio, Joao Tavares, Joana Fonseca Ferreira, Armando Malcata
We report a case of a 46-year-old woman with a history of autoimmune atrophic gastritis and recurrent erythema nodosum (EN). Laboratory results showed iron-deficiency anaemia, positive antiparietal cell antibodies and marginal deficiency of vitamin B12. Although EN was refractory to general measures (rest and non-steroidal anti-inflammatory drugs) and corticosteroid therapy, it was successfully treated with vitamin B12 supplementation.
March 15, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29519989/-helicobacter-pylori-and-precancerous-lesions-of-the-stomach-in-a-nigerian-metropolis-a-cohort-study
#14
E Ray-Offor, C C Obiorah
Introduction: Helicobacter pylori (H. pylori)-related atrophic gastritis transits through a sequential pathway of intestinal metaplasia, dysplasia to gastric cancer. Gastroscopy offers early detection, treatment and surveillance of gastric cancer. Aims: This study aims to study the prevalence of H. pylori infection and evaluate precancerous lesions (PCLs) of the stomach. Patients and Methods: This is a case controlled study of patients with dyspepsia undergoing gastroscopy at a referral endoscopy facility in Port Harcourt metropolis of Nigeria...
March 2018: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29518896/use-of-metabolomics-as-a-complementary-omic-approach-to-implement-risk-criteria-for-first-degree-relatives-of-gastric-cancer-patients
#15
Giuseppe Corona, Renato Cannizzaro, Gianmaria Miolo, Laura Caggiari, Mariangela De Zorzi, Ombretta Repetto, Agostino Steffan, Valli De Re
A positive family history is a strong and consistently reported risk factor for gastric cancer (GC). So far, it has been demonstrated that serum pepsinogens (PGs), and gastrin 17 (G17) are useful for screening individuals at elevated risk to develop atrophic gastritis but they are suboptimal biomarkers to screen individuals for GC. The main purpose of this study was to investigate serum metabolomic profiles to find additional biomarkers that could be integrated with serum PGs and G17 to improve the diagnosis of GC and the selection of first-degree relatives (FDR) at higher risk of GC development...
March 7, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29493162/-clinical-therapy-of-zisheng-decoction-recipe-for-chronic-atrophic-gastritis-with-intestinal-metaplasia
#16
Xiu-Xia Wu, Xian Li, Zhong-Qin Dang, Wen-Zhao Luo, Chang-Pu Zhao, Kun Yu
To explore the therapeutic effect and security of Zisheng decoction recipein treatment of the chronic atrophic gastritis (CAG) with intestinal metaplasia(IM). A total of 147 eligible cases were randomly divided into the traditional Chinese medicine group, Western medicine group and the combined group,47 cases in each group. Zisheng decoction recipe, famotidine, as well as Zisheng decoction recipe + famotidine were respectively given in the above three groups, with a treatment course of 30 d. The symptoms of traditional Chinese medicine, pathological score of gastric mucosa and the negative rate of Helicobacter pylori before and after treatment were observed in each group...
December 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29484193/serological-biomarker-testing-helps-avoiding-unnecessary-endoscopies-in-obese-patients-before-bariatric-surgery
#17
Jaanus Suumann, Toomas Sillakivi, Živile Riispere, Kari Syrjänen, Pentti Sipponen, Ülle Kirsimägi, Ants Peetsalu
Background: To assess the value of serological biomarker testing as a substitute for esophagogastroduodenoscopy (EGDS) in pre-operative assessment of patients referred for bariatric surgery. Methods: Sixty-five obese patients with a mean age of 43 years (range: 21-65) and a mean body mass index (BMI) of 44 (range: 36-59) were studied. The patients were tested with a four-biomarker panel: pepsinogen I and II, gastrin-17 (basal and stimulated), and Helicobacter pylori (HP) antibodies (GastroPanel®, Biohit Oyj, Finland)...
2018: BMC Obesity
https://www.readbyqxmd.com/read/29483497/lectin-binding-patterns-in-normal-dysplastic-and-helicobacter-pylori-infected-gastric-mucosa
#18
S Vernygorodskyi, V Shkolnikov, D Suhan
AIM: To analyze the glycoprotein binding sites of the gastric mucosa and its secreted mucus using lectin histochemistry in patients with chronic non-atrophic gastritis (CNAG) associated or not-associated with Helicobacter pylori infection with or without dysplasia. MATERIALS AND METHODS: In order to identify the areas with glycoconjugates expression in gastric mucosa, 6 lectins (Canavalia ensiformis agglutinin - Con A, Sambucus nigra agglutinin - SNA, wheat germ agglutinin - WGA, soybean agglutinin - SBA, Helix pomatia agglutinin - HPA, peanut agglutinin - PNA) were used...
July 2017: Experimental Oncology
https://www.readbyqxmd.com/read/29477376/is-preoperative-gastroscopy-necessary-before-sleeve-gastrectomy-and-roux-en-y-gastric-bypass
#19
Tuure Saarinen, Ulla Kettunen, Kirsi H Pietiläinen, Anne Juuti
BACKGROUND: Consensus on the necessity of esophagogastroduodenoscopy (EGD) before bariatric surgery is lacking. Recommendations and practices vary by country and unit. Several reports have expressed concerns on gastroesophageal reflux disease (GERD) and its consequences after sleeve gastrectomy (SG) and the risk of leaving a premalignant lesion in the excluded stomach after Roux-en-Y gastric bypass (RYGB). OBJECTIVES: We explored the number and types of clinically significant findings in preoperative EGDs and how they associate with preexisting GERD-symptoms (SG) and premalignant lesions (RYGB)...
February 14, 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29434449/impact-of-snp-snp-interactions-of-dna-repair-gene-ercc5-and-metabolic-gene-gstp1-on-gastric-cancer-atrophic-gastritis-risk-in-a-chinese-population
#20
Liang Sang, Zhi Lv, Li-Ping Sun, Qian Xu, Yuan Yuan
AIM: To investigate the interactions of the DNA repair gene excision repair cross complementing group 5 (ERCC5) and the metabolic gene glutathione S-transferase pi 1 (GSTP1) and their effects on atrophic gastritis (AG) and gastric cancer (GC) risk. METHODS: Seven ERCC5 single nucleotide polymorphisms (SNPs) (rs1047768, rs2094258, rs2228959, rs4150291, rs4150383, rs751402, and rs873601) and GSTP1 SNP rs1695 were detected using the Sequenom MassARRAY platform in 450 GC patients, 634 AG cases, and 621 healthy control subjects in a Chinese population...
February 7, 2018: World Journal of Gastroenterology: WJG
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