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Atrophic gastritis

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https://www.readbyqxmd.com/read/29434449/impact-of-snp-snp-interactions-of-dna-repair-gene-ercc5-and-metabolic-gene-gstp1-on-gastric-cancer-atrophic-gastritis-risk-in-a-chinese-population
#1
Liang Sang, Zhi Lv, Li-Ping Sun, Qian Xu, Yuan Yuan
AIM: To investigate the interactions of the DNA repair gene excision repair cross complementing group 5 (ERCC5) and the metabolic gene glutathione S-transferase pi 1 (GSTP1) and their effects on atrophic gastritis (AG) and gastric cancer (GC) risk. METHODS: Seven ERCC5 single nucleotide polymorphisms (SNPs) (rs1047768, rs2094258, rs2228959, rs4150291, rs4150383, rs751402, and rs873601) and GSTP1 SNP rs1695 were detected using the Sequenom MassARRAY platform in 450 GC patients, 634 AG cases, and 621 healthy control subjects in a Chinese population...
February 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29415337/host-response-genes-associated-with-nodular-gastritis-in-h-pylori-infection
#2
Tamaki Ikuse, Yoshikazu Ohtsuka, Naho Obayashi, Keisuke Jimbo, Yo Aoyagi, Takahiro Kudo, Daisuke Asaoka, Mariko Hojo, Akihito Nagahara, Sumio Watanabe, Thomas G Blanchard, Steven J Czinn, Toshiaki Shimizu
BACKGROUND: Chronic Helicobacter pylori (H. pylori) infection in children induces lymphoid hyperplasia called nodular gastritis (NG) at the antral gastric mucosa. The aim of this study was to evaluate genes in gastric biopsies by microarray analysis to identify molecules associated with NG when compared to NG-negative pediatric corpus tissue and H. pylori-infected adult tissue with atrophic gastritis (AG). METHODS: Eight pediatric and six adult H. pylori-infected patients, as well as six pediatric and six adult uninfected patients were evaluated...
February 7, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29403459/-helicobacter-pylori-and-gastric-cancer-adaptive-cellular-mechanisms-involved-in-disease-progression
#3
REVIEW
Paula Díaz, Manuel Valenzuela Valderrama, Jimena Bravo, Andrew F G Quest
Helicobacter pylori ( H. pylori ) infection is the major risk factor associated with the development of gastric cancer. The transition from normal mucosa to non-atrophic gastritis, triggered primarily by H. pylori infection, initiates precancerous lesions which may then progress to atrophic gastritis and intestinal metaplasia. Further progression to dysplasia and gastric cancer is generally believed to be attributable to processes that no longer require the presence of H. pylori . The responses that develop upon H...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29403299/ethnic-racial-differences-in-gastrointestinal-symptoms-and-diagnosis-associated-with-the-risk-of-helicobacter-pylori-infection-in-the-us
#4
Maria-Raquel Huerta-Franco, Julie W Banderas, Jenifer E Allsworth
Background: In the US, neither the prevalence nor the gastrointestinal (GI) diagnosis/symptoms associated with Helicobacter pylori (HP) have been examined in different racial/ethnic groups. Aim: To determine the racial/ethnic differences in HP infection associated with GI diagnoses/symptoms using the Cerner Health Facts® database. Methods: This cross-sectional study collected data during the period of 2000-2015 from the following ethnic/racial groups: 8,236,317 white, 2,085,389 black, 426,622 Hispanic, 293,156 Asian Pacific/Islander (APIs), and 89,179 Native American/Alaskan Native (NA/AN) patients aged 21-65 years old; the data were then analyzed...
2018: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/29393198/does-the-novel-potassium-competitive-acid-blocker-vonoprazan-cause-more-hypergastrinemia-than-conventional-proton-pump-inhibitors-a-multicenter-prospective-cross-sectional-study
#5
Yuichi Kojima, Toshihisa Takeuchi, Makoto Sanomura, Ken Higashino, Keishi Kojima, Kenji Fukumoto, Kou Takata, Hiroki Sakamoto, Masahiro Sakaguchi, Kazunari Tominaga, Kazuhide Higuchi
BACKGROUND/AIM: The long-term administration of proton pump inhibitors (PPIs) is useful for preventing recurrent reflux esophagitis. On the other hand, several adverse reactions, such as an increase in the blood gastrin level, have been reported. The aim of the present study was to examine the increase in the blood gastrin level due to the long-term administration of conventional PPIs compared with vonoprazan. METHODS: A prospective cross-sectional study was conducted...
February 1, 2018: Digestion
https://www.readbyqxmd.com/read/29371789/case-report-of-a-small-gastric-neuroendocrine-tumor-in-a-deep-layer-of-submucosa-with-diagnosis-by-endoscopic-ultrasound-guided-fine-needle-aspiration-and-treatment-with-laparoscopic-and-endoscopic-cooperative-surgery
#6
Ryo Igarashi, Atsushi Irisawa, Goro Shibukawa, Nobutoshi Soeta, Ai Sato, Akane Yamabe, Mariko Fujisawa, Noriyuki Arakawa, Yoshitsugu Yoshida, Tsunehiko Ikeda, Yoko Abe, Takumi Maki, Shogo Yamamoto, Ikuro Oshibe, Takuro Saito, Hiroshi Hojo
Gastric neuroendocrine tumors (GNETs) are rare lesions characterized by enterochromaffin-like cells of the stomach. Optimal management of GNETs has not yet been definitively determined. Endoscopic resection is approximately recommended for small GNETs associated with hypergastrinemia. However, endoscopic resection might present risk of perforation or positive vertical margin because neuroendocrine tumors occur in the deep mucosa, with some invading the submucosa. In this case, a patient with type A chronic atrophic gastritis had a small subepithelial lesion in a deep submucosal layer, and we diagnosed it as GNET using endoscopic ultrasound-guided fine-needle aspiration biopsy using a forward-viewing and curved linear-array echoendoscope...
2018: Clinical Medicine Insights. Case Reports
https://www.readbyqxmd.com/read/29369216/helicobacter-pylori-eradication-may-influence-timing-of-endoscopic-surveillance-for-gastric-cancer-in-patients-with-gastric-precancerous-lesions-a-retrospective-study
#7
Maria Pina Dore, Alice Cipolli, Matteo Walter Ruggiu, Alessandra Manca, Gabrio Bassotti, Giovanni Mario Pes
Chronic atrophic gastritis and intestinal metaplasia related to Helicobacter pylori infection, are major risk factors for gastric adenocarcinoma. Eradication of H pylori and endoscopy surveillance of precancerous lesions may reduce the risk and/or lead to early detection of gastric cancer improving survival. In this study, the progression of precancerous lesions after H pylori treatment was evaluated.Patients with incomplete or complete intestinal metaplasia and/or gastric atrophy at the index endoscopy, were examined for the extension/histological worsening of precancerous lesions at the endoscopy surveillance for gastric cancer...
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29364158/the-prevalence-of-helicobacter-pylori-in-estonian-bariatric-surgery-patients
#8
Natalja Šebunova, Jelena Štšepetova, Toomas Sillakivi, Reet Mändar
Helicobacter pylori (Hp) is one of the most important human pathogens that can cause duodenal and gastric ulcers, gastritis and stomach cancer. Hp infection is considered to be a cause of limiting access to bariatric surgery. The aim of this study was to determine the prevalence of Hp in patients with obesity going into bariatric surgery and to reveal the relationship between Hp and clinical data. The study group was formed of 68 preoperative bariatric surgery patients (body mass index (BMI) 44.7 ± 4.8). Gastric biopsies (antrum and corpus) were used for histological and molecular (caqA and glmM genes) examinations...
January 24, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29361173/the-changing-face-of-noncardia-gastric-cancer-incidence-among-us-non-hispanic-whites
#9
William F Anderson, Charles S Rabkin, Natalie Turner, Joseph F Fraumeni, Philip S Rosenberg, M Constanza Camargo
Background: The initial step for noncardia gastric carcinogenesis is atrophic gastritis, driven by either Helicobacter pylori infection or autoimmunity. In recent decades, the prevalence rates of these two major causes declined and increased, respectively, with changes in Western lifestyles. We therefore assessed gastric cancer incidence trends for US race/ethnic groups, 1995-2013. Methods: Age-standardized rates (ASRs) from 45 North American Association of Central Cancer Tumor Registries were summarized by estimated annual percentage change (EAPC) and 95% confidence intervals (CIs)...
January 19, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29353492/psychological-distress-in-patients-with-chronic-atrophic-gastritis-the-risk-factors-protection-factors-and-cumulative-effect
#10
Yaoyao Sun, Shumei Wang, Ming Qi, Menglian Wu, Dan Zhang, Yang Yang, Xia Zhao, Jihui Jia, Fenglin Cao, Yonggang Su, Shuhong Zhang
This study aimed to examine the psychological status among Chronic Atrophic Gastritis (CAG) patients and to find the cumulative effects of risk and protective factors. A sample of 101 CAG patients completed the investigation. Hierarchical linear regression was used to find risk and protective factors, and examine the cumulative effects in risk factor index (RFI) and protective factor index (PFI). Results showed that nine symptoms from SCL-90-R were severer among CAG patients than those in adult norm. Risk factors including positive family history of cancer and higher negative life events could predict higher GSI (β = 0...
January 20, 2018: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/29319200/the-rise-and-fall-of-peptic-ulceration-a-disease-of-civilization
#11
REVIEW
Ian C Roberts-Thomson
Humans and Helicobacter pylori have evolved and adapted over tens of thousands of years. Yet peptic ulcer disease appeared to be rare prior to the 19th century. The prevalence of peptic ulcer disease increased between 1850 and 1900 and culminated in a cohort at high risk that was born at the end of the 19th century. This coincided with the provision of safe water and improvements in sanitation and personal hygiene. One hypothesis for the emergence of peptic ulcer disease focuses on the rate of development of atrophic gastritis induced by Helicobacter pylori...
January 10, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29310112/hypergastrinemia-in-long-term-use-of-proton-pump-inhibitors
#12
Akiko Shiotani, Ryo Katsumata, Kyousuke Gouda, Shinya Fukushima, Rui Nakato, Takahisa Murao, Manabu Ishii, Minoru Fujita, Hiroshi Matsumoto, Takashi Sakakibara
BACKGROUND/AIM: The use of proton pump inhibitors (PPIs) is known to lead to hypergastrinemia; however, the data in patients with atrophic gastritis is still lacking. The aim of this study was to investigate the effects of long-term PPIs use on the gastrin levels in patients with atrophic gastritis and to determine factors affecting hypergastrinemia in long-term users of PPIs. METHODS: Serum Helicobacter pylori IgG, gastrin and pepsinogen levels were measured. Atrophic gastritis was assessed by upper gastrointestinal endoscopies based on the Kimura-Takemoto classification and pepsinogen levels...
January 8, 2018: Digestion
https://www.readbyqxmd.com/read/29300536/autoimmune-polyendocrine-syndrome-type-2-in-patient-with-severe-allergic-asthma-treated-with-omalizumab
#13
Anna Rams, Marek Żółciński, Weronika Zastrzeżyńska, Stanisław Polański, Agnieszka Serafin, Joanna Wilańska, Jacek Musiał, Stanisława Bazan-Socha
Asthma therapy with monoclonal antibodies is a promising and effective approach for those with a severe and refractory type of disease. Although such a targeted therapy is considered to be safe, unusual complications may occur. We present a case of a 45 year-old female patient with severe allergic asthma and chronic spontaneous urticaria, who developed autoimmune polyendocrine syndrome type 2 (APS-2) after 26 months of omalizumab administration. The patient was diagnosed with primary adrenal insufficiency (Addison's disease) and Hashimoto's thyroiditis accompanied by autoimmune atrophic gastritis...
January 4, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29273468/systematic-gastric-biopsy-in-iron-deficiency-anaemia
#14
Hela Elloumi, Meriam Sabbah, Achraf Debbiche, Asma Ouakaa, Norsaf Bibani, Dorra Trad, Dalila Gargouri, Jamel Kharrat
BACKGROUND AND STUDY AIMS: Gastric biopsies are recommended in patients with iron deficiency anaemia to identify atrophic gastritis. However, in practice, only duodenal biopsies are routinely performed. The aim of our study was to determine the value of gastric biopsies in iron deficiency anaemia. PATIENTS AND METHODS: A prospective study including all patients referred for gastrointestinal endoscopy for iron deficiency anaemia from May 2008 to September 2014 was performed...
December 19, 2017: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://www.readbyqxmd.com/read/29248442/metaplastic-cells-in-the-stomach-arise-independently-of-stem-cells-via-dedifferentiation-or-transdifferentiation-of-chief-cells
#15
Megan D Radyk, Joseph Burclaff, Spencer G Willet, Jason C Mills
Spasmolytic polypeptide-expressing metaplasia (SPEM) develops in patients with chronic atrophic gastritis due to infection with Helicobacter pylori; it might be a precursor to intestinal metaplasia and gastric adenocarcinoma. Lineage tracing experiments of the gastric corpus in mice have not established whether SPEM derives from proliferating stem cells or differentiated, post-mitotic zymogenic chief cells in the gland base. We investigated whether differentiated cells can give rise to SPEM using a non-genetic approach in mice...
December 14, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29231474/-warm-acupuncture-for-chronic-atrophic-gastritis-with-spleen-stomach-deficiency-cold
#16
Lijun Wang, Guangqi Li
OBJECTIVE: To observe the clinical effect of warm acupuncture at Zhongwan(CV 12) for chronic atrophic gastritis(CAG) with spleen-stomach deficiency cold by the comparison with conventional acupuncture. METHODS: Sixty-two patients were randomly assigned into a warm acupuncture group and a conventional acupuncture group,31 cases in each one. The acupoints in the two groups were Zhongwan(CV 12),Zusanli(ST 36),Neiguan(PC 6),Gongsun(SP 4),Qihai(CV 6),Pishu(BL 20) and Weishu(BL 21)...
February 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29221129/long-non-coding-rna-polymorphisms-in-6p21-1-are-associated-with-atrophic-gastritis-risk-and-gastric-cancer-prognosis
#17
Zhi Lv, Liping Sun, Qian Xu, Yuehua Gong, Jingjing Jing, Chengzhong Xing, Yuan Yuan
It has been suggested that the genetic variation in human chromosome 6p21.1 has potential importance for the susceptibility to gastric cancer (GC). The study aims to explore the relationship between the long non-coding RNA (lncRNA) polymorphisms in 6p21.1 and the risk of GC as well as atrophic gastritis (AG). Genotyping for eight single nucleotide polymorphisms (SNPs) was conducted using Sequenom MassARRAY platform in a total of 2507 northern Chinese subjects, including 749 GC cases, 878 AG cases and 880 controls...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29215433/gastritis-staging-as-a-clinical-priority
#18
Claudia Mescoli, Aly Gallo Lopez, Luis Taxa Rojas, Walker Jove Oblitas, Matteo Fassan, Massimo Rugge
The elective background for gastric adenocarcinoma is the atrophic transformation of the gastric mucosa. The extent of mucosal atrophy basically parallels the risk of developing gastric cancer. This means that either noninvasive (serology) or invasive (endoscopy/histology) methods enabling the atrophic transformation to be quantified can be used theoretically to assess a given patient's gastric cancer risk. This review aims to focus on the reliability of histology gastritis Operative Link for Gastritis Assessment -staging system for assessing the 'personalized' cancer risk in individuals with (atrophic) gastritis...
February 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29200968/volatile-organic-metabolites-identify-patients-with-gastric-carcinoma-gastric-ulcer-or-gastritis-and-control-patients
#19
Hongshuang Tong, Yue Wang, Yue Li, Shujuan Liu, Chunjie Chi, Desheng Liu, Lei Guo, Enyou Li, Changsong Wang
Background: Gastric cancer ranks 4th among the most common cancers worldwide, and the mortality caused by gastric cancer is 2nd only to lung cancer. Gastric cancer shows a lack of specific symptoms in its early stages. In addition, its clinical symptoms often do not match the corresponding stage. Upper gastrointestinal endoscopy with biopsy is the gold standard for the diagnosis of gastric cancer because of its high accuracy. However, this operation is invasive, patient compliance is poor, and high demands for medical staff and equipment are typical of this procedure...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/29193217/reversibility-of-atrophic-gastritis-and-intestinal-metaplasia-after-helicobacter-pylori-eradication-a-prospective-study-for-up-to-10-years
#20
Y-J Hwang, N Kim, H S Lee, J B Lee, Y J Choi, H Yoon, C M Shin, Y S Park, D H Lee
BACKGROUND: Atrophic gastritis and intestinal metaplasia are premalignant conditions for gastric cancer. Their reversibility by Helicobacter pylori eradication remains controversial. AIM: To evaluate the reversibility of atrophic gastritis and intestinal metaplasia by H. pylori eradication with long-term follow-up. METHODS: 598 subjects were prospectively enrolled and followed for up to 10 years. They were categorised as H. pylori-negative (n = 65), H...
February 2018: Alimentary Pharmacology & Therapeutics
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