keyword
MENU ▼
Read by QxMD icon Read
search

Gastrointestinal stromal tumor

keyword
https://www.readbyqxmd.com/read/29777611/extragastrointestinal-stromal-tumor-egist-a-16-year-experience-of-13-cases-diagnosed-at-a-single-center
#1
Engin Hatipoğlu
BACKGROUND Gastrointestinal stromal tumor (GISTs) rarely occurs outside the GI tract as extragastrointestinal stromal tumor (EGIST). The aim of this study was to review the clinical presentation, diagnosis, and outcome of EGIST at a single center. MATERIAL AND METHODS The study was a retrospective study performed at Istanbul University Hospital in a 16-year period and included patients with a histopathological diagnosis of EGIST confirmed to arise outside the GI tract. The patients' available medical records included patient demographics, imaging and surgical data, and diagnostic histopathology reports...
May 19, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29776634/molecular-diagnostics-in-the-neoplasms-of-small-intestine-and-appendix-2018-update
#2
REVIEW
Yingtao Zhang, Muhammad Zulfiqar, Martin H Bluth, Amarpreet Bhalla, Rafic Beydoun
Neoplasms of the small intestine are rare in comparison with colorectal tumors. The most common tumor types arising in the small intestine are adenocarcinomas, well-differentiated neuroendocrine tumors, gastrointestinal stromal tumors, and lymphoma. Primary appendiceal neoplasms are rare and found in less than 2% of appendectomy specimens with an incidence of approximately 1.2 cases per 100,000 people per year in the United States. This article explores molecular diagnostics in the neoplasms of small intestine and appendix...
June 2018: Clinics in Laboratory Medicine
https://www.readbyqxmd.com/read/29766411/gastrointestinal-stromal-tumors-risk-of-recurrence-stratification-by-tumor-volume-is-a-best-predictor-compared-with-risk-based-on-mitosis-and-tumor-size
#3
Leonardo S Lino-Silva, Patricia Segales-Rojas, Eduardo Aguilar-Cruz, Rosa A Salcedo-Hernández, César Zepeda-Najar
PURPOSE: Gastrointestinal stromal tumors (GIST) have the potential to recur and metastasize. Several prognostic schemes have been developed, mostly based on the mitotic count, diameter, and tumor site. However, these systems are not precise enough. The research question was whether the tumor size determined by volumetry allows a better risk stratification than the traditional system, and our aim was to determine the value of tumor volumetry, a feasible and simple parameter, in the recurrence of GIST...
May 16, 2018: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29764388/clinicopathological-features-surgical-strategy-and-prognosis-of-duodenal-gastrointestinal-stromal-tumors-a-series-of-300-patients
#4
Zhen Liu, Gaozan Zheng, Jinqiang Liu, Shushang Liu, Guanghui Xu, Qiao Wang, Man Guo, Xiao Lian, Hongwei Zhang, Fan Feng
BACKGROUND: The relatively low incidence of duodenal gastrointestinal stromal tumors (GISTs) and the unique anatomy make the surgical management and outcomes of this kind of tumor still under debate. Thus, this study aimed to explore the optimal surgical strategy and prognosis of duodenal GISTs. METHODS: A total of 300 cases of duodenal GISTs were obtained from our center (37 cases) and from case reports or series (263 cases) extracted from MEDLINE. Clinicopathological features, type of resections and survivals of duodenal GISTs were analyzed...
May 15, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29764009/a-rare-duodenal-subepithelial-tumor-duodenal-schwannoma
#5
Dong Hwahn Kahng, Gwang Ha Kim, Sang Gyu Park, So Jeong Lee, Do Youn Park
Schwannomas are uncommon neoplasms that arise from Schwann cells of the neural sheath. Gastrointestinal schwannomas are rare among mesenchymal tumors of the gastrointestinal tract, and only a few cases have been reported to date. Duodenal schwannomas are usually discovered incidentally and achieving a preoperative diagnosis is difficult. Schwannomas can be distinguished from other subepithelial tumors on endoscopic ultrasonography; however, any typical endosonographic features of duodenal schwannomas have not been reported due to the rarity of these tumors...
May 15, 2018: Clinical Endoscopy
https://www.readbyqxmd.com/read/29760538/gastrointestinal-stromal-tumors-a-multidisciplinary-challenge
#6
REVIEW
Juan Manuel Sanchez-Hidalgo, Manuel Duran-Martinez, Rafael Molero-Payan, Sebastian Rufian-Peña, Alvaro Arjona-Sanchez, Angela Casado-Adam, Antonio Cosano-Alvarez, Javier Briceño-Delgado
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors located in the alimentary tract. Its usual manifestation is gastrointestinal bleeding. However, small asymptomatic lesions are frequently detected as incidental finding. Characteristically, most GISTs (> 95%) are positive for the KIT protein (CD117) by IHC staining and approximately 80%-90% of GISTs carry a mutation in the c-KIT or PDGFRA genes. Mutational analysis should be performed when planning adjuvant and neoadjuvant therapy, due to its possible resistance to conventional treatment...
May 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29759015/morphologic-and-immunohistochemical-characteristics-of-anorectal-melanoma
#7
Ahmad Charifa, Xuchen Zhang
Anorectal melanoma is a rare aggressive disease. Due to its rarity and considerable histologic and immunohistochemical variabilities, misdiagnosis as lymphoma, carcinoma, sarcoma, and/or gastrointestinal stromal tumor is not uncommon, particularly in amelanotic cases. We reviewed histologic features and immunohistochemical stains of 19 anorectal melanoma cases. Histopathologic features were evaluated including junctional activity, melanin pigment, and morphologic features. Immunohistochemical stains were performed using Sox10, S100 protein, HMB-45, melan-A, CD56, and cytokeratins...
May 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29755907/the-100-most-influential-papers-and-recent-trends-in-the-field-of-gastrointestinal-stromal-tumours-a-bibliometric-analysis
#8
Khadijah Siddiq, Hira F Akbar, Meeshal Khan, Amna A Siddiqui, Salman Nusrat, Jean Y Blay
Background Bibliometric analysis is a statistical tool used to examine the exponential growth in medical research. Many analogous analyses have been conducted, but none existed for gastrointestinal stromal tumors (GISTs). Hence, we conducted a citation analysis of the hundred most cited and recently published articles on this topic. Methods Scopus was chosen as the primary database, through which the top 100 and recent publications were ranked according to the citation count and were then analysed. Results The 100 most cited articles were published between 1992 and 2013, among which the greatest number of articles were published in the years 2002 (n = 15) and 2006 (n = 11)...
March 12, 2018: Curēus
https://www.readbyqxmd.com/read/29755776/gastrointestinal-stromal-tumors-in-the-imatinib-era-15-years-experience-of-a-tertiary-center
#9
Armando Peixoto, Pedro Costa-Moreira, Marco Silva, Ana Luísa Santos, Susana Lopes, Filipe Vilas-Boas, Pedro Moutinho-Ribeiro, Guilherme Macedo
Gastrointestinal stromal tumors (GISTs) were associated with a disease free survival rate of disease of 50% at 5 years, but the actual natural history since the advent of imatinib is poorly described. Our objective was to evaluate the evolution in the treatment and prognosis of patients with GISTs since the start of imatinib. Retrospective analysis of GISTs diagnosed between January 2000 and June 2015 in a Portuguese large volume center. We included 131 patients, 55% female, with a mean age of 64±14 years, followed for a median of 30 months; 64% of cases had gastric involvement; 92% of the tumors were c-Kit positive; 95% of patients were operated...
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29755761/distinctive-features-of-gastrointestinal-stromal-tumors-arising-from-the-colon-and-rectum
#10
Rebecca Zhu, Fangfang Liu, Gabriella Grisotti, Javier Pérez-Irizarry, Charles H Cha, Caroline H Johnson, Daniel J Boffa, Dale Han, Kimberly L Johung, Yawei Zhang, Sajid A Khan
Background: Colon and rectal gastrointestinal stromal tumors (GISTs) are rare and poorly characterized. Because the majority of treatment guidelines for GISTs are extrapolated from tumors of gastric and small bowel origin, our aim was to better characterize the unique clinicopathologic features and prognostic factors of colon and rectal GISTs to guide clinical care. Methods: The National Cancer Data Base (NCDB) was queried from 2006 to 2013 for cases of GISTs in the stomach, colon, and rectum...
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29752602/clinicopathological-features-and-prognosis-of-primary-gists-with-tumor-rupture-in-the-real-world
#11
Toshirou Nishida, Haruhiko Cho, Seiichi Hirota, Toru Masuzawa, Gaku Chiguchi, Toshimasa Tsujinaka
BACKGROUND: Patients with ruptured gastrointestinal stromal tumor (GIST) are recommended for imatinib adjuvant therapy; however, their clinicopathological features and prognosis in the era of imatinib are unknown. PATIENTS AND METHODS: The study cohort included 665 patients with histologically proven primary GISTs who underwent R0 or R1 surgery between 2003 and 2007; the validation cohort included 182 patients between 2000 and 2014. The definitions of tumor rupture in the study included perforation at tumor site, tumor fracture, piecemeal resection including open biopsy, and macroscopic injuries to the pseudocapsule...
May 11, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29752328/soft-tissue-sarcoma-version-2-2018-nccn-clinical-practice-guidelines-in-oncology
#12
Margaret von Mehren, R Lor Randall, Robert S Benjamin, Sarah Boles, Marilyn M Bui, Kristen N Ganjoo, Suzanne George, Ricardo J Gonzalez, Martin J Heslin, John M Kane, Vicki Keedy, Edward Kim, Henry Koon, Joel Mayerson, Martin McCarter, Sean V McGarry, Christian Meyer, Zachary S Morris, Richard J O'Donnell, Alberto S Pappo, I Benjamin Paz, Ivy A Petersen, John D Pfeifer, Richard F Riedel, Bernice Ruo, Scott Schuetze, William D Tap, Jeffrey D Wayne, Mary Anne Bergman, Jillian L Scavone
Soft tissue sarcomas (STS) are rare solid tumors of mesenchymal cell origin that display a heterogenous mix of clinical and pathologic characteristics. STS can develop from fat, muscle, nerves, blood vessels, and other connective tissues. The evaluation and treatment of patients with STS requires a multidisciplinary team with demonstrated expertise in the management of these tumors. The complete NCCN Guidelines for STS provide recommendations for the diagnosis, evaluation, and treatment of extremity/superficial trunk/head and neck STS, as well as intra-abdominal/retroperitoneal STS, gastrointestinal stromal tumors, desmoid tumors, and rhabdomyosarcoma...
May 2018: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29745093/imatinib-therapy-after-resection-of-high-risk-gastrointestinal-stromal-tumors-in-chinese-patients-a-median-follow-up-of-48-months
#13
Cheng Lei, Bing Zhao, Qisan Wang, Lei Ge, Haijiang Wang
PURPOSE: Adjuvant imatinib can be given for gastrointestinal stromal tumors (GISTs), but adequate risk stratification is necessary to select patients who will benefit from this therapy. We aimed to investigate the treatment methods and prognostic factors of high risk GISTs. METHODS: This retrospective study included 108 patients who underwent tumor resection for high-risk GISTs between January 2003 and February 2017. The patients were divided into two groups: a group of patients received postoperative imatinib adjuvant therapy (Adjuvant therapy group), and the other group was not treated with imatinib until they were found to have disease progression (Followup observation group)...
March 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29744029/treatment-patterns-and-survival-among-older-adults-in-the-united-states-with-advanced-soft-tissue-sarcomas
#14
Rohan C Parikh, Maria Lorenzo, Lisa M Hess, Sean D Candrilli, Steven Nicol, James A Kaye
Background: To describe patient and tumor characteristics, treatments, and survival among older adults in the United States with advanced soft-tissue sarcoma (STS), across and by categories of specifically defined histologic subtypes. Methods: We conducted a retrospective cohort analysis using the SEER. The study population comprised patients ≥ 65 years old with advanced STS (excluding osteosarcoma, Kaposi sarcoma, and gastrointestinal stromal tumors) diagnosed from January 1, 2001 to December 31, 2011...
2018: Clinical Sarcoma Research
https://www.readbyqxmd.com/read/29742764/ectopic-pancreas-mimicking-gastrointestinal-stromal-tumor-in-the-stomach-fundus
#15
Cătălina Diaconu, Mihai Ciocîrlan, Mariana Jinga, Raluca Simona Costache, Gabriel Constantinescu, Mădălina Ilie, Mircea Diculescu
No abstract text is available yet for this article.
May 9, 2018: Endoscopy
https://www.readbyqxmd.com/read/29734250/gastrointestinal-stromal-tumor-with-multiple-primary-tyrosine-kinase-mutations-clinicopathologic-and-molecular-characterization
#16
Newton A C S Wong, Philippe Taniere, Shaun Walsh, Andrew Wallace, Daisuke Nonaka, Thomas Jones, David Gonzalez
A unique cohort of chemo-naive gastrointestinal stromal tumors (GISTs) with double-primary tyrosine kinase mutations was characterized particularly to determine whether coexistent mutations represent a single mutational event. Up to 2013, 4 UK centers reported 9 GISTs with 2 primary tyrosine kinase mutations. In each of 8 cases validated by next generation sequencing, both mutations were present in the same allele of the same exon (KIT exon 11 or 17, or PDGFRA exon 18). One case showed the second mutation only on some of the mutant alleles...
May 4, 2018: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/29732727/cytomorphology-of-epithelioid-gastrointestinal-stromal-tumor
#17
Miguel Dario Cantu, Abha Goyal
No abstract text is available yet for this article.
May 6, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29724628/the-rare-coexistence-of-high-titer-inhibitor-development-and-gastrointestinal-stromal-tumor-in-a-patient-with-severe-hemophilia-a-case-report
#18
Abdulkerim Yıldız, Osman Şahin, Okan Yayar, Çiğdem Pala Öztürk, Hacer Berna Afacan Öztürk, Senem Maral, Harika Okutan, Murat Albayrak
Hemophilia is a hereditary disease with impaired blood coagulation due to a genetic deficiency of blood coagulation factors. The development of inhibitors further complicates the course of the disease and management. The case is here reported of a haemophilia patient who presented with coexisting development of high titer inhibitor with Gastrointestinal Stromal Tumor (GIST) diagnosis and was admitted with upper gastrointestinal system bleeding. The patient had no prior history of inhibitor presence. During all procedures including surgery, excellent hemostasis was achieved with rFVIIa treatment and no hemorrhagic complication was observed...
April 26, 2018: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29724301/-clinical-value-of-multi-slice-spiral-enhanced-ct-in-diagnosing-mild-digestive-tract-hemorrhage
#19
Xiao Ling Wen, Li Wang, Xiao Qin Song, Zhi Zhang, Xiao Fang Zhu, Shao Ping Wu
Objective To investigate the clinical value of multi-slice spiral CT(MSCT) in the diagnosis of mild digestive tract hemorrhage. Methods Thirty-five patients with mild gastrointestinal hemorrhage were examined by enhanced MSCT.CT signs were observed and compared with pathologic examination findings.Results Diseases in these 35 patients included gastric and duodenal ulcer and inflammation(n=4,11.4%),esophagogastric variceal rupture(n=7,20.0%),gastric carcinoma(n=3,8.6%),gastric stromal tumor(n=3,8.6%),gastric polyp(n=1,2...
April 28, 2018: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/29721368/cell-surface-vimentin-positive-macrophage-like-circulating-tumor-cells-as-a-novel-biomarker-of-metastatic-gastrointestinal-stromal-tumors
#20
Heming Li, Qing H Meng, Hyangsoon Noh, Neeta Somaiah, Keila E Torres, Xueqing Xia, Izhar S Batth, Cissimol P Joseph, Mengyuan Liu, Ruoyu Wang, Shulin Li
The clinical utility of circulating tumor cells (CTCs) has been investigated in numerous publications, but CTCs that express very typical immune cell markers have not been reported. Here we report a novel class of CTCs-CSV-positive macrophage-like CTCs (ML-CTCs). This nomenclature was based on the fact that this class of CTCs can be captured from blood samples of gastrointestinal stromal tumors (GISTs) patients using either the macrophage marker CD68 or our proprietary tumor-specific cell-surface vimentin (CSV) antibody 84-1; likewise, the captured ML-CTCs can be co-stained with both typical macrophage markers (CD14, CD68) and tumor cell markers (DOG-1, C-kit) but not CD45...
2018: Oncoimmunology
keyword
keyword
17582
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"