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Liver neoplasms

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https://www.readbyqxmd.com/read/29324517/long-term-care-of-transplant-recipients-de-novo-neoplasms-after-liver-transplantation
#1
Patrizia Burra, Sarah Shalaby, Alberto Zanetto
PURPOSE OF REVIEW: Since the first liver transplantation in the early 1960s, there have been significant improvements in the recipients' long-term outcome. Patients who have undergone transplantation are exposed to a high risk of developing neoplastic disease, not only because of their chronic immunosuppression, but also related to physiological aging, lifestyle, chronic viral infections, liver disease cause, and carcinogenic immunosuppressants. The present review covers the latest and most relevant data on de novo neoplasms after liver transplantation, and discusses their implications for clinical practice...
January 9, 2018: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/29309807/solitary-fibrous-tumor-with-neuroendocrine-and-squamous-dedifferentiation-a-potential-diagnostic-pitfall
#2
Chuanyong Lu, Deepu Alex, Ryma Benayed, Marc K Rosenblum, Meera R Hameed
Solitary fibrous tumor (SFT) is a ubiquitous mesenchymal neoplasm of deep soft tissue with variable and often unpredictable biological behavior. The lineage is presumed to be fibroblastic and histological features range from benign to overtly malignant with rare tumors showing "dedifferentiation" or transformation to undifferentiated pleomorphic sarcoma. Dedifferentiation in mesenchymal neoplasms is a phenomenon of histologic progression of a well-differentiated neoplasm to a high-grade sarcoma which can differentiate along divergent lines...
January 5, 2018: Human Pathology
https://www.readbyqxmd.com/read/29307997/nomogram-based-on-tumor-associated-neutrophil-to-lymphocyte-ratio-to-predict-survival-of-patients-with-gastric-neuroendocrine-neoplasms
#3
Long-Long Cao, Jun Lu, Jian-Xian Lin, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Qi-Yue Chen, Mi Lin, Ru-Hong Tu, Chang-Ming Huang
AIM: To assess the predictive value of the tumor-associated neutrophil-to-lymphocyte ratio in terms of the clinical outcomes of patients with gastric neuroendocrine neoplasms after radical surgery. METHODS: Data were retrospectively collected from 142 patients who were diagnosed with gastric neuroendocrine neoplasms and who underwent radical gastrectomy at our department from March 2006 to March 2015. These data were retrospectively analyzed, and a receiver operating characteristic curve analysis was used to identify the optimal value of the tumor-associated neutrophil-to-lymphocyte ratio...
December 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29301491/pancreatic-panniculitis-the-bright-side-of-the-moon-in-solid-cancer-patients
#4
Elena Guanziroli, Antonella Colombo, Antonella Coggi, Raffaele Gianotti, Angelo Valerio Marzano
BACKGROUND: Pancreatic panniculitis is a rare complication of pancreas disorders occurring in 0.3-3% of patients, most often accompanied by the pancreatic acinar carcinoma. It presents multiple, painful, deep, ill-defined, red-brown, migratory nodules and plaques of hard elastic consistency; often ulcerated and typically located on the lower proximal and distal extremities. The pathogenesis is not fully understood, but it is thought to result from lipolysis and fat necrosis with secondary tissue inflammation induced by pancreatic enzymes...
January 4, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29290661/are-liver-nested-stromal-epithelial-tumors-always-low-aggressive
#5
Tania Meletani, Luca Cantini, Andrea Lanese, Daniele Nicolini, Alessia Cimadamore, Andrea Agostini, Giulia Ricci, Stefania Antognoli, Alessandra Mandolesi, Maria Guido, Rita Alaggio, Gian Marco Giuseppetti, Marina Scarpelli, Marco Vivarelli, Rossana Berardi
Nested stromal-epithelial tumor (NSET) is a non-hepatocytic and non-biliary tumor of the liver consisting of nests of epithelial and spindled cells with associated myofibroblastic stroma and variable intra-lesional calcification and ossification, which represents a very rare and challenging disease. Most of the reported cases have been treated with surgery, obtaining a long survival outcome. Here, we report the case of a 31-year-old Caucasian man who underwent surgery at our institution for a large, lobulated, multinodular mass of the right hemi-liver...
December 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29290491/induction-of-apoptosis-by-pyrazolo-3-4-d-pyridazine-derivative-in-lung-cancer-cells-via-disruption-of-bcl-2-bax-expression-balance
#6
Mervat S Mohamed, Abdou O Abdelhamid, Fahad M Almutairi, Ayat G Ali, Mai K Bishr
In the rapidly expanding era of cancer target therapy, regulators of apoptosis are emerging as attractive therapeutic targets. X-linked inhibitor of apoptosis (XIAP) is of specific interest owing to its characteristic overexpression in a wide variety of neoplasms, with a resultant survival advantage for tumor cells and treatment resistance. In this study, we examined three pyrazolo [3,4-d] pyridazine derivatives (PPDs) through molecular modeling and studied their modes of interaction with XIAP-BIR3 domain. PPD-1, which possessed the highest binding affinity with XIAP, was tested on A549 (lung cancer cell line); HCT-116 (colorectal carcinoma cell line); HEPG2 (liver carcinoma cell line), HFB4 (normal human skin melanocyte cell line) and WI-38 (human embryonic lung fibroblasts)...
December 20, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29285598/diagnosis-of-budd-chiari-syndrome
#7
Morgane Van Wettere, Onorina Bruno, Pierre-Emmanuel Rautou, Valérie Vilgrain, Maxime Ronot
Budd-Chiari syndrome (BCS) is defined by clinical and laboratory signs associated with partial or complete impairment of hepatic venous drainage in the absence of right heart failure or constrictive pericarditis. Primary BCS is the most frequent type and is a complication of hypercoagulable states, in particular myeloproliferative neoplasms. Secondary BCS involves tumor invasion or extrinsic compression. Most patients present with chronic BCS including a non-cirrhotic, dysmorphic, chronic liver disease with various degrees of fibrosis deposition...
December 28, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/29279599/solid-pseudopapillary-neoplasm-of-the-pancreas-with-liver-metastasis-initially-misinterpreted-as-benign-haemorrhagic-cyst
#8
M J Jung, H K Kim, S Y Choi, S G Kim, S Y Jin
Solid pseudopapillary neoplasm (SPN) of the pancreas is considered a low-malignant neoplasm with a good prognosis. However, 5% to 15% of patients with SPNs develop metastatic disease, most commonly in the liver. Metastatic hepatic malignancies that show pseudocystic features are rare. Here we describe the case of a middle-aged female with a cystic liver metastasis from SPN. To the best of our knowledge, SPN with a single cystic liver metastasis has not been described, although these tumours frequently undergo haemorrhagic-cystic degeneration...
December 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/29250690/difficulty-in-positive-diagnosis-of-ascites-and-in-differential-diagnosis-of-a-pulmonary-tumor
#9
Mircea Cătălin ForŢofoiu, Dragoş Marian Popescu, Vlad Pădureanu, Aurelian Constantin Dobrinescu, Adrian Gabriel Dobrinescu, Adrian Mită, Maria Camelia Foarfă, Violeta Serenada Bălă, Anca Emanuela Muşetescu, Nina Ionovici, Maria ForŢofoiu
Ascites is the most frequent complication of cirrhosis and occurs only when the portal hypertension has already installed but ascites is caused by neoplasms, heart failure, tuberculosis, pancreatic illnesses, as well as other kind of affections. We describe the case of a 67-year-old patient, a retired person, without significant personal or familial history, nonsmoker, infrequent alcohol and coffee consumer with following chief complaints at onset: loss of appetite, weight loss, serious physical asthenia, delayed intestinal transit, diffuse abdominal pain and increase of abdominal circumference...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/29248834/cerebellar-metastasis-of-gastrointestinal-stromal-tumor-a-case-report-and-review-of-the-literature
#10
Mohamed Badri, Mohamed Chabaane, Ghassen Gader, Kamel Bahri, Ihsen Zammel
INTRODUCTION: Intracranial metastases of gastro intestinal tumors are very rare. To the best of our knowledge only few cases were reported on the literature. CASE DESCRIPTION: We describe the case of 66-year-old male that presented with headache and vomiting. Physical examination found a kinetic cerebellar syndrome. Brain CT scan and MRI showed a right cerebellar tumor. Sub-occipital craniotomy was performed and the tumor was completely resected. Surgical outcomes were marked by the occurrence of an abdominal pain two days after brain surgery...
December 13, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29245304/computed-tomography-imaging-features-of-hepatic-perivascular-epithelioid-cell-tumor-a-case-report-and-literature-review
#11
Xu Han, Mei-Yu Sun, Jing-Hong Liu, Xiao-Yan Zhang, Meng-Yao Wang, Rui Fan, Sahrish Qamar
RATIONALE: Perivascular epithelioid cell tumor (PEComa) is a rare tumor which is most frequently found in uterus. The tumor arising from liver is extremely uncommon. PATIENT CONCERNS: A 36-year-old female with abdominal distention, cramps, and low-grade fever for over 15 days. The patient had a history of gastric adenocarcinoma with ovarian, celiac lymph nodes, and retroperitoneal lymph nodes metastases. DIAGNOSES: Computed tomography (CT) imaging demonstrated an ill-defined heterogeneous hypo-dense mass in segment 8 (S8) of the liver...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29245287/an-inflammatory-myofibroblastic-tumor-in-the-transplanted-liver-displaying-quick-wash-in-and-wash-out-on-contrast-enhanced-ultrasound-a-case-report
#12
Jing Shang, Yun-Yue Wang, Ying Dang, Xin-Juan Zhang, Yan Song, Li-Tao Ruan
RATIONALE: Inflammatory myofibroblastic tumor (IMT) is an uncommon mesenchymal neoplasm, and its presence in a grafted liver is exceedingly rare. PATIENT CONCERNS: A 54-year-old woman was admitted to our hospital with a half-month history of intermittent melena. She had undergone deceased-donor liver transplantation (LT) for hepatitis B virus related liver cirrhosis without hepatocellular carcinoma 5 months previously. DIAGNOSIS: Laboratory examination showed impaired liver and renal functions and Epstein-Barr virus (EBV) infection, but tumor markers within normal ranges...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29245237/a-rare-case-of-angiosarcoma-with-skull-masses-and-erythropenia-and-thrombocytopenia-a-case-report-and-review-of-literature
#13
Liansheng Gao, Weilin Xu, Tao Li, Huali Luo, Shiying Gai, Ruxin Xing, Gao Chen, Yili Chen
RATIONALE: Primary splenic angiosarcoma (PSA) is a rare, fatal neoplasm originating from sinusoidal vascular endothelial cells, and usually metastasizes and almost always has a poor prognosis. Surgical excision is the main treatment of this highly malignant disease. PATIENT CONCERNS: We reported a special case of a 68-year-old female who had a 6-month history of scalp masses. DIAGNOSIS: The patient was found to have 2 skull masses on computed tomography (CT)...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29236275/multidisciplinary-management-of-a-giant-cervico-mediastinal-liposarcoma-a-case-report-and-literature-review
#14
Andrea Galli, Leone Giordano, Piergiorgio Muriana, Alessandro Bandiera, Giampiero Negri, Piero Zannini, Mario Bussi
Liposarcomas are rare mesenchymal tumors that usually develop in lower extremities or retroperitoneum; cervico-mediastinal presentation is quite uncommon. These neoplasms are commonly diagnosed at a late stage because they remain asymptomatic until nearby structures are compressed. This makes radical excision particularly challenging. To date, alternative chemoradiotherapy protocols have not yet been standardized. We report a case of a 55-year-old man with a right laterocervical mass and without substantial symptoms...
December 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/29230130/periampullary-carcinoma-unusual-sites-of-metastasis
#15
Anju Bansal, Varsha Dalal, Manveen Kaur, Fouzia Siraj
Background: Periampullary neoplasms include carcinomas of the duodenum, ampulla of Vater, distal common bile duct, and pancreas. The aggressive course of these neoplasms is attributable to the delay in diagnosis, as patients have no symptoms until advanced stages of the disease. More than half of patients have distant metastasis at the time of diagnosis. The most frequent sites of metastasis are the liver, lymph nodes, peritoneum, lung, bone, kidney, and, rarely the skin. Case Report: We report the case of a 45-year-old female patient with adenocarcinoma of the ampulla of Vater metastasizing to the right parietal skull with overlying cutaneous involvement 1 year after a Whipple procedure...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/29228674/the-regulatory-role-of-aberrant-phosphatase-and-tensin-homologue-and-liver-kinase-b1-on-akt-mtor-c-myc-axis-in-pancreatic-neuroendocrine-tumors
#16
Tsung-Ming Chang, Yan-Shen Shan, Pei-Yi Chu, Shih Sheng Jiang, Wen-Chun Hung, Yu-Lin Chen, Hsiu-Chi Tu, Hui-You Lin, Hui-Jen Tsai, Li-Tzong Chen
Pancreatic neuroendocrine tumor (pNET) is an uncommon type of pancreatic neoplasm. Low Phosphatase and Tensin Homologue (PTEN) expression and activation of the mechanistic target of rapamycin (mTOR) pathway have been noted in pNETs, and the former is associated with poor survival in pNET patients. Based on the results of the RADIANT-3 study, everolimus, an oral mTOR inhibitor, has been approved to treat advanced pNETs. However, the exact regulatory mechanism for the mTOR pathway in pNETs remains largely unknown...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228125/myeloid-neoplasms-following-solid-organ-transplantation-clinicopathologic-studies-of-23-cases
#17
Bin Wu, Kimberly Ingersoll, Rachel Jug, Lian-He Yang, Catherine Luedke, Amanda Lo, Pu Su, Xin Liu, Catherine Rehder, Jerald Gong, Chuanyi Mark Lu, Endi Wang
Objectives: Myeloid neoplasms (MNs) after solid organ transplant are rare, and their clinicopathologic features have not been well characterized. Methods: We retrospectively analyzed 23 such cases. Results: The ages ranged from 2 to 76 years, with a median of 59 years at the diagnosis. The median interval between the transplant and diagnosis was 56 months (range, 8-384 months). The transplanted organs included liver in five, kidney in six, lung in five, heart in six, and heart/lung in one case(s)...
December 7, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29225981/tricuspid-valve-endocarditis-due-to-streptococcus-bovis-in-a-patient-with-ventricular-septal-defect-a-rare-manifestation-case-report-and-review-of-the-literature
#18
J Pushpakumara, G Mudiyanse, A Jayawardana, J Siriwardana, N L A Shyamali, J Indrakumar
Streptococcus bovis endocarditis has 18%-62% association with colonic neoplasms with multivalvular involvement and affects mainly elderly males leading to severe cardiac dysfunction, septic embolization, and neurological complications. The aortic valve is the commonest valve to be affected followed by aortic and mitral valves together. However, involvement of tricuspid valve is extremely rare. There are no reported cases of Streptococcus bovis endocarditis affecting the tricuspid valve in the presence of ventricular septal defect with left to right shunt...
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/29215535/the-clinicopathological-aspects-of-primary-presacral-neuroendocrine-neoplasms-one-center-experience
#19
Guoqing Yang, Deepti Dhall, Run Yu, Richard Tuli, Farin F Amersi, Marc L Friedman, Nicholas N Nissen, Andrew E Hendifar
OBJECTIVES: Presacral neuroendocrine neoplasms (NENs) are rare entities that are found at the presacral space. We report our experience in the diagnosis, management, and outcomes of primary presacral NENs. METHODS: This was an institutional review board-approved retrospective review of medical records and surgical pathology specimens of patients with a diagnosis of NENs at Cedars-Sinai Medical Center between January 2000 and April 2016. RESULTS: Ten patients were identified...
December 5, 2017: Pancreas
https://www.readbyqxmd.com/read/29214888/minimally-invasive-surgical-approach-for-radicalization-of-incidental-post-cholecystectomy-gallbladder-carcinoma-safety-feasibility-and-outcomes
#20
Emanuele Sinagra, Stefano Garritano, Salvatore Marco Iacopinelli, Marco Messina, Dario Raimondo, Francesca Rossi, Massimiliano Spada, Guido Martorana, Marcello Giuseppe Spampinato
BACKGROUND AND AIMS: Gallbladder carcinoma is a rare but aggressive malignant neoplasm. The incidence of intra- or post-operative incidental gallbladder carcinoma diagnosis following laparoscopic cholecystectomy is estimated to be 1-2%. Aggressive re-resection is warranted as the majority of patients have residual disease either in the liver or the lymph nodes. However the use of a minimally invasive surgical approach (MISA) to perform a radicalization in these patients has not been investigated yet...
December 7, 2017: Minimally Invasive Therapy & Allied Technologies: MITAT
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