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Appendiceal adenocarcinoma

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https://www.readbyqxmd.com/read/29776634/molecular-diagnostics-in-the-neoplasms-of-small-intestine-and-appendix-2018-update
#1
REVIEW
Yingtao Zhang, Muhammad Zulfiqar, Martin H Bluth, Amarpreet Bhalla, Rafic Beydoun
Neoplasms of the small intestine are rare in comparison with colorectal tumors. The most common tumor types arising in the small intestine are adenocarcinomas, well-differentiated neuroendocrine tumors, gastrointestinal stromal tumors, and lymphoma. Primary appendiceal neoplasms are rare and found in less than 2% of appendectomy specimens with an incidence of approximately 1.2 cases per 100,000 people per year in the United States. This article explores molecular diagnostics in the neoplasms of small intestine and appendix...
June 2018: Clinics in Laboratory Medicine
https://www.readbyqxmd.com/read/29764845/endoscopic-diagnosis-of-a-goblet-cell-carcinoid-tumour-of-the-appendix
#2
Vanessa Falk, Marcia Ballantyne, Sergio Zepeda-Gómez, Ali Kohansal-Vajargah
Primary malignancies of the appendix are rare. Of these, less than 5% are goblet cell carcinoid (GCC) tumours. The majority of GCC present with findings of acute appendicitis or advanced peritoneal spread. We describe a rare presentation of GCC as subtle mucosal abnormality of the appendiceal orifice seen on colonoscopy performed for iron-deficiency anaemia. Biopsies were interpreted as adenocarcinoma; however, final surgical pathology confirmed GCC of the appendix with caecal involvement. The patient recovered well from surgery, anaemia resolved and follow-up did not show metastatic disease...
May 15, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29755780/appendiceal-diverticulosis-a-harbinger-of-underlying-primary-appendiceal-adenocarcinoma
#3
Jia Lin Ng, Shing Lih Wong, Ronnie Mathew
Diagnosis of primary appendiceal adenocarcinoma (PAA) is hindered by its rarity and largely asymptomatic nature. Appendiceal diverticulosis (AD) is equally rare. We report an unusual case of PAA presenting with perforated appendiceal diverticulitis, and discuss a review of the literature about its association, and its surgical and pathological implications. A middle-aged man was admitted with right iliac fossa (RIF) pain and a corresponding tender abdominal mass for 5 days. Computerised tomography (CT) scan demonstrated a thickened appendix with 3 cm abscess at its base...
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29750708/endometrioid-adenocarcinoma-with-solitary-metastasis-to-the-appendix-mimicking-primary-appendiceal-adenocarcinoma-a-case-report-and-literature-review
#4
Qiujie Ma, Jianshe Wu
Metastatic tumors of the appendix are rare. Endometrial cancer tends to metastasize by directly invading neighboring structures; the lung, liver, bones, and brain are common sites of distant metastasis. Herein, we present a case of a solitary endometrial metastatic tumor in the appendiceal mucosa without serosal involvement that mimicked a primary adenocarcinoma of the appendix. The patient who had undergone a radical hysterectomy for an endometrioid adenocarcinoma 3 years earlier presented to the hospital with a history of persistent right-lower abdominal pain...
May 10, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29725538/appendiceal-carcinoma-associated-with-microsatellite-instability
#5
Angélica Morales-Miranda, Ismael Domínguez Rosado, Carlos Chan Núñez, Fredy Chable Montero
Approximately 15% of colorectal cancer (CRC) cases exhibit microsatellite instability (MSI), which appears to be associated with unique biological behavior. The present study presents a case of appendiceal carcinoma associated with MSI that responded well to adjuvant chemotherapy. Clinical, pathological and immunohistochemical (IHC) characteristics have been described. The 60-year-old male patient had suffered from recurrent lower abdominal pain associated with abdominal distention for 6 months; then, following an acute attack, he was subjected to laparoscopic appendectomy...
May 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29719746/sister-mary-joseph-nodule-as-a-cutaneous-manifestation-of-metastatic-appendiceal-adenocarcinoma-case-report-and-literature-review
#6
Raghavendra L Girijala, Ryan R Riahi, Philip R Cohen
Sister Mary Joseph nodule (SMJN) is an uncommon pattern of superficial periumbilical tumor metastasis, with the primary tumor most commonly associated with gynecological or gastrointestinal origins. This manifestation can represent extensive tumor development from any of the intra-abdominal or pelvic structures. Therefore, SMJN carries a poor prognosis, with a two-year survival rate of only 13.5 percent regardless of the etiology of primary cancer. In this case, a 67-year-old man with metastatic mucinous adenocarcinoma of the appendix involving the umbilicus presenting more than five years after the initial cancer diagnosis is reported...
February 28, 2018: Curēus
https://www.readbyqxmd.com/read/29705882/severe-peritoneal-sclerosis-after-repeated-pressurized-intraperitoneal-aerosol-chemotherapy-with-oxaliplatin-pipac-ox-report-of-two-cases-and-literature-survey
#7
M Graversen, S Detlefsen, P Pfeiffer, L Lundell, M B Mortensen
Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a new laparoscopic administration of chemotherapy for peritoneal metastasis (PM). PIPAC is repeated every 5th week, and seems to stabilize or improve quality of life, and might improve survival. So far, PIPAC has been well tolerated. With this paper, we aim to highlight a potential severe adverse reaction, as we describe the first cases of severe peritoneal sclerosis (SPS) caused by PIPAC. Patients with isolated PM were included in a prospective PIPAC protocol...
April 28, 2018: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/29698881/goblet-cell-carcinoid-of-the-appendix-case-report-of-a-high-grade-tumor-in-a-20-year-old
#8
Ameen Barghi, John Grabbe, Arundhati Ghosh
INTRODUCTION: Goblet cell carcinoid (GCC) is an extraordinarily rare appendiceal tumor that is usually an incidental diagnosis on post-operative histology. It typically presents in the fifth or sixth decade of life. Our patient is the only reported case study of GCC in a pediatric-young adult. Due to its potentially poor prognosis, GCC is surgically treated as an adenocarcinoma, with right hemicolectomy as the mainstay of treatment. PRESENTATION OF CASE: The patient was a 20-year-old male who presented with a history, physical exam, and work up consistent with acute appendicitis...
April 16, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29656783/nationwide-overview-of-survival-and-management-of-appendiceal-tumors-in-children
#9
Punam P Parikh, Eduardo A Perez, Holly L Neville, Anthony R Hogan, Juan E Sola
INTRODUCTION: There remains a paucity of literature on survival related to pediatric appendiceal tumors. The purpose of this study was to determine the incidence, surgical management, and survival outcomes of appendiceal tumors in pediatric patients. METHODS: The Surveillance, Epidemiology, and End Results (SEER) Registry was analyzed for pediatric appendiceal tumors from 1973 to 2011. Parameters analyzed were: tumor type, surgical management (appendectomy vs. extensive resection), tumor size, and lymph node sampling...
March 6, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29650824/-a-case-report-of-appendiceal-cancer-complicated-appendicitis-treated-with-single-incision-laparoscopic-ileocecal-resection
#10
Taiki Kijima, Hideto Hayashi, Hikari Chijimatsu, Yasunori Yoshimoto, Katsuhiko Morita, Kouichiro Sakata, Mihoko Setoguchi
We report a case of appendicitis with an abscess that was treated with single-incision laparoscopic ileocecal resection with D2 lymphadenectomy because of intraoperative suspicion of appendiceal cancer. A 73-year-old woman was admitted to the hospital because of right lower abdominal pain. She was diagnosed with appendicitis with an abscess. Although single-incision laparoscopic appendectomy was planned, appendiceal cancer was suspected from intraoperative findings. Therefore, we performed single-incision laparoscopic ileocecal resection with D2 lymphadenectomy...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29579011/histologic-and-outcome-study-supports-reclassifying-appendiceal-goblet-cell-carcinoids-as-goblet-cell-adenocarcinomas-and-grading-and-staging-similarly-to-colonic-adenocarcinomas
#11
Masato Yozu, Melanie E Johncilla, Amitabh Srivastava, David P Ryan, James C Cusack, Leona Doyle, Namrata Setia, Michelle Yang, Gregory Y Lauwers, Robert D Odze, Joseph Misdraji
Goblet cell carcinoid tumors are amphicrine tumors whose biological behavior ranges from indolent to highly aggressive, depending on tumor grade. Current grading systems for these tumors are based on identifying an adenocarcinoma arising in the setting of a goblet cell carcinoid tumor, which distinguishes this tumor from other gastrointestinal tract adenocarcinomas. Because goblet cell tumors are predominantly tumors of mucin secreting cells, we propose that they be classified as goblet cell adenocarcinomas, and graded using a methodology that has parallels in colorectal adenocarcinoma grading...
March 23, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29559034/development-of-bone-metastasis-secondary-to-appendiceal-adenocarcinoma-with-signet-ring-cells
#12
Amanda N Goldin, Ashish Mittal, Anna A Kulidjian
No abstract text is available yet for this article.
March 1, 2018: American Surgeon
https://www.readbyqxmd.com/read/29515086/mr-imaging-of-secondary-massive-ovarian-edema-caused-by-ovarian-metastasis-from-appendiceal-adenocarcinoma
#13
Yumiko Oishi Tanaka, Yutaka Takazawa, Motoki Matsuura, Kohei Omatsu, Nobuhiro Takeshima, Kiyoshi Matsueda
No abstract text is available yet for this article.
March 7, 2018: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/29483455/-a-case-of-laparoscopy-assisted-ileocecal-resection-for-large-appendiceal-mucinous-adenocarcinoma
#14
Masahiro Hashimoto, Kohei Murata, Yoshinori Kagawa, Atsushi Naito, Kenji Kawai, Takuya Sakamoto, Kohei Murakami, Yoshiteru Katsura, Akihisa Omura, Toru Masuzawa, Atsushi Takeno, Michiko Yoshimura, Yutaka Takeda, Takeshi Kato, Shigeyuki Tamura
Appendiceal mucinous adenocarcinoma accompanied by cysts ruptures by surgical operation and leakage of mucus into the peritoneal cavity results in deterioration of prognosis.We report a case where the appendix mucinous adenocarcinoma was safely excised by laparoscopically preceding vascular treatment, lymph node dissection and intestinal dissection.The case was a woman in her forty-age suffering from the right lower quadrant and fever; no improvement was observed even when antibiotics were administered.A cystic lesion with a maximum diameter of 75mm was found on the right side of the pelvis with CT, and numerous lymph adenopathy was observed along the iliac artery...
February 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394656/-a-case-of-appendiceal-mucinous-adenocarcinoma-detected-with-a-bladder-tumor
#15
Shinji Tsutsumi, Akihiko Murata, Yoichi Yamauchi, Kensuke Okano, Hiroshi Yokoyama, Akitoshi Kimura, Yoshiya Ishizawa, Minoru Umehara, Masashi Kato, Naoki Hashimoto, Yutaka Umehara, Shinsuke Nishikawa, Kenichi Takahashi, Takayuki Morita
A 74-year-oldwoman hadconsultedthe department of urology in our hospital because of microscopic hematuria. Cystoscopy revealeda urinary bladder tumor, suspectedas an adenocarcinoma basedon biopsy. MRI showeda cystic tumor of the appendix with vesical fistula; therefore, she underwent an operation with a diagnosis of appendiceal cancer invading the urinary bladder. During the operation, we found that the appendix sunk into the urinary bladder with right adnexa. Therefore, we performed ileocecal resection, partial resection of the urinary bladder, and right adnexectomy...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394640/-a-two-stage-right-hemicolectomy-case-in-which-the-first-surgery-was-laparoscopic-ileocecal-resection-based-on-preoperative-diagnosis-of-acute-appendicitis
#16
Satoshi Kataoka, Kei Naito, Koji Miyagawa, Yosuke Ishihara, Nobuaki Fuji
We report a case oftwo -stage right hemicolectomy in which the first surgery performed was laparoscopic ileocecal resection based on the preoperative diagnosis ofacute appendicitis. The second surgery was performed based on pathological diagnosis ofadvanced cecal cancer accompanied by appendicitis. A 49-year-old woman came to our hospital with a chief complaint of abdominal pain in the lower quadrant for 1 week. Blood test results indicated an inflammatory response, with white blood cells at 10,000/mL and C-reactive protein of1 7...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29327707/appendiceal-goblet-cell-carcinoids-and-adenocarcinomas-ex-goblet-cell-carcinoid-are-genetically-distinct-from-primary-colorectal-type-adenocarcinoma-of-the-appendix
#17
Moritz Jesinghaus, Björn Konukiewitz, Sebastian Foersch, Albrecht Stenzinger, Katja Steiger, Alexander Muckenhuber, Claudia Groß, Martin Mollenhauer, Wilfried Roth, Sönke Detlefsen, Wilko Weichert, Günter Klöppel, Nicole Pfarr, Anna Melissa Schlitter
The appendix gives rise to goblet cell carcinoids, which represent special carcinomas with distinct biological and histological features. Their genetic background and molecular relationship to colorectal adenocarcinoma is largely unknown. We therefore performed a next-generation sequencing analysis of 25 appendiceal carcinomas including 11 goblet cell carcinoids, 7 adenocarcinomas ex-goblet cell carcinoid, and 7 primary colorectal-type adenocarcinomas, using a modified Colorectal Cancer specific Panel comprising 32 genes linked to colorectal and neuroendocrine tumorigenesis...
January 12, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29282599/histologic-predictors-of-recurrence-in-mucinous-appendiceal-tumors-with-peritoneal-dissemination-after-hipec
#18
Meera Reghunathan, Kaitlyn J Kelly, Mark A Valasek, Andrew M Lowy, Joel M Baumgartner
BACKGROUND: Mucinous appendiceal tumors (MAT) are rare neoplasms that can metastasize to the peritoneum and often are treated with cytoreductive surgery (CRS) and HIPEC. Pathologic classification and outcomes vary, but standardized histologic definitions are emerging. We sought to evaluate outcomes in this disease after CRS/HIPEC using standardized pathologic criteria. METHOD: Outcomes of MAT with peritoneal metastases (PM) after CRS/HIPEC from 2007 to 2015 were reviewed at our institution...
March 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29193085/elevated-brain-natriuretic-peptide-bnp-is-an-early-marker-for-patients-at-risk-for-complications-after-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-crs-hipec
#19
Sarah B Fisher, Safia Rafeeq, Ken Hess, Travis E Grotz, Paul Mansfield, Richard Royal, Brian Badgwell, Jason Fleming, Keith Fournier, Gary N Mann
BACKGROUND: Elevated BNP is associated with adverse cardiac outcomes after noncardiac surgery. We assessed BNP values as markers of perioperative fluid status and their correlation with major/cardiopulmonary (CP) complications following CRS + HIPEC. METHODS: Fluid balance, BNP levels, and morbidity data were collected for all patients undergoing CRS + HIPEC between 6/2014 and 2/2016. RESULTS: One hundred and twenty-nine patients underwent CRS + HIPEC for appendiceal adenocarcinoma (n = 99), mesothelioma (n = 16), and colon cancer (n = 14)...
November 28, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29133621/the-mutational-landscape-of-gastrointestinal-malignancies-as-reflected-by-circulating-tumor-dna
#20
Paul Riviere, Paul T Fanta, Sadakatsu Ikeda, Joel Baumgartner, Gregory M Heestand, Razelle Kurzrock
We aimed to assess the utility of a novel, noninvasive method of detecting genomic alterations in patients with gastrointestinal malignancies, i.e., the use of liquid biopsies to obtain blood-derived circulating tumor DNA (ctDNA) through an analysis of the genomic landscape of ctDNA (68 genes) from 213 patients with advanced gastrointestinal cancers. The most common cancer types were colorectal adenocarcinoma ( N = 55; 26%), appendiceal adenocarcinoma ( N = 46; 22%), hepatocellular carcinoma ( N = 31; 15%), and pancreatic ductal adenocarcinoma ( N = 25; 12%)...
January 2018: Molecular Cancer Therapeutics
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