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Appendiceal adenocarcinoma

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https://www.readbyqxmd.com/read/28188838/lymph-node-positivity-in-appendiceal-adenocarcinoma-should-size-matter
#1
John V Gahagan, Matthew D Whealon, Michael J Phelan, Steven Mills, Alessio Pigazzi, Michael J Stamos, Ninh T Nguyen, Joseph C Carmichael
BACKGROUND: The management algorithm for appendiceal adenocarcinoma is not well defined. This study sought to determine whether tumor size or depth of invasion better correlates with the presence of lymph node metastases in appendiceal adenocarcinoma, and to compare these rates to colon adenocarcinoma. STUDY DESIGN: A retrospective review of the National Cancer Database was performed to identify patients with appendiceal or colonic adenocarcinoma from 2004 to 2013 who underwent surgical resection...
February 7, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28138447/diarrhea-concealing-a-duodenal-cecal-fistula-secondary-to-appendiceal-mucinous-neoplasm
#2
Su Aung, Amanda Cheung, Charlene Prather, Jinping Lai
Primary mucinous adenocarcinoma of the appendix is a rare gastrointestinal malignancy. Fistulous tract formation is a complication that is cited in literature. An 85-year-old man with multiple comorbidities presented with several weeks of persistent non-bloody diarrhea. Laboratory work-up was non-diagnostic. Abdominal imaging with barium contrast showed an enterocolonic fistulous tract extending from the duodenum to the cecum involving an enlarged appendiceal mass. Subsequent biopsy confirmed mucinous appendiceal neoplasm with peritoneal spread to the liver and mesentery...
2017: ACG Case Reports Journal
https://www.readbyqxmd.com/read/28112040/intralymphatic-histiocytosis-of-the-appendix-and-fallopian-tube-associated-with-primary-peritoneal-high-grade-poorly-differentiated-adenocarcinoma-of-m%C3%A3-llerian-origin
#3
Tien Anh N Tran, Quang Tran, J Andrew Carlson
Intralymphatic histiocytosis (ILH) is a peculiar pathological process characterized by the collections of benign histiocytes in dilated lymph vessels. Although the majority of ILH patients present clinically with various forms of cutaneous manifestation, rare extracutaneous incidences have been reported in the literature. To date, ILH has not been described in an internal visceral organ. We report the case of a 68-year-old woman who underwent an appendectomy during a surgical procedure for a primary peritoneal high-grade, poorly differentiated adenocarcinoma of Müllerian origin...
January 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28060142/the-importance-of-appendectomy-in-surgery-for-mucinous-adenocarcinoma-of-the-ovary
#4
Mikkel Rosendahl, Laura Amalie Haueberg Oester, Claus Kim Høgdall
OBJECTIVE: The aim of this study was to assess the importance of appendectomy during surgery for mucinous ovarian cancer. It can be difficult to distinguish between primary ovarian and primary appendiceal cancers clinically, histologically, and immunohistochemically. Removal of the appendix may facilitate differential diagnosis, improve staging, and possibly increase 5-year survival but may also be associated with increased postsurgical morbidity. In the largest population published to date, we analyze and discuss these matters...
March 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28050146/personalized-oncogenomics-in-the-management-of-gastrointestinal-carcinomas-early-experiences-from-a-pilot-study
#5
B S Sheffield, B Tessier-Cloutier, H Li-Chang, Y Shen, E Pleasance, K Kasaian, Y Li, S J M Jones, H J Lim, D J Renouf, D G Huntsman, S Yip, J Laskin, M Marra, D F Schaeffer
BACKGROUND: Gastrointestinal carcinomas are genomically complex cancers that are lethal in the metastatic setting. Whole-genome and transcriptome sequencing allow for the simultaneous characterization of multiple oncogenic pathways. METHODS: We report 3 cases of metastatic gastrointestinal carcinoma in patients enrolled in the Personalized Onco-Genomics program at the BC Cancer Agency. Real-time genomic profiling was combined with clinical expertise to diagnose a carcinoma of unknown primary, to explore treatment response to bevacizumab in a colorectal cancer, and to characterize an appendiceal adenocarcinoma...
December 2016: Current Oncology
https://www.readbyqxmd.com/read/27990774/appendiceal-adenocarcinoma-masquerading-as-a-primary-rectal-tumour
#6
Tamara M Vu, Jonathan A Simpson, A Craig Lynch, Satish Warrier, Alexander Heriot
No abstract text is available yet for this article.
December 18, 2016: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/27982068/the-management-and-prognostic-prediction-of-adenocarcinoma-of-appendix
#7
Xin Xie, Zhangjian Zhou, Yongchun Song, Wenhan Li, Dongmei Diao, Chengxue Dang, Hao Zhang
Malignant tumours of the appendix are quite rare, especially appendiceal adenocarcinomas, which may be difficult to detect preoperatively or intraoperatively. We collected data for 1404 patients with adenocarcinoma of the appendix from the Surveillance, Epidemiology, and End Results Program (SEER) database to explore the potential associations between clinicopathological factors and overall survival. Furthermore, a novel nomogram for predicting prognosis was developed based on our analysis of the SEER data...
December 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27913947/preclinical-evaluation-of-cathepsin-based-fluorescent-imaging-system-for-cytoreductive-surgery
#8
Carlos H F Chan, Lukas F Liesenfeld, Isabel Ferreiro-Neira, James C Cusack
BACKGROUND: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) is a treatment option for peritoneal surface malignancies. The ability to detect microscopic foci of peritoneal metastasis intraoperatively may ensure the completeness of cytoreduction. In this study, we evaluated the suitability of a hand-held cathepsin-based fluorescent imaging system for intraoperative detection of appendiceal and colorectal peritoneal metastasis. METHODS: Peritoneal tumors and normal peritoneal tissues were collected from patients with appendiceal and colorectal peritoneal metastasis...
December 2, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27889016/is-it-necessary-to-perform-routine-appendectomy-for-mucinous-ovarian-neoplasms-a-retrospective-study-and-meta-analysis
#9
REVIEW
Aoshuang Cheng, Minghao Li, Margaux J Kanis, Ying Xu, Qing Zhang, Baoxia Cui, Jie Jiang, YouZhong Zhang, Xingsheng Yang, Beihua Kong
OBJECTIVES: To evaluate whether routine appendectomy is necessary in all patients with mucinous borderline ovarian tumor (mBOT) or mucinous ovarian cancer (MOC) who undergo gynecologic surgery. METHODS: The database of Qilu Hospital was searched for women who underwent appendectomy in a primary surgery for an ovarian tumor between June 2005 and June 2015 and whose final diagnosis was mBOT, MOC or primary appendiceal tumor. A retrospective review was performed, as well as a meta-analysis of the literature to further validate the findings...
January 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/27858376/a-case-of-adenocarcinoma-arising-in-an-ileal-diverticulum-resected-by-laparoscopic-surgery
#10
Ryo Ikeshima, Junichi Nishimura, Hidekazu Takahashi, Naotsugu Haraguchi, Taishi Hata, Tsunekazu Mizushima, Yuichiro Doki, Masaki Mori
Adenocarcinoma arising in an ileal diverticulum are very rare. A 66-year-old man was recognized to have high serum CEA level and periappendiceal polycystic tumor in CT findings. Colonoscopy showed no abnormality in the ileocecal mucosa. However, the patient was suspected of appendiceal adenocarcinoma by PET/CT, which revealed FDG uptake with SUVmax of 3.9 in the tumor, and underwent radial surgery by single-incision laparoscopic surgery. Intraoperative findings showed the mass in the mesenterium of the terminal ileum but not the abnormality of the appendix...
December 2016: Surgical Case Reports
https://www.readbyqxmd.com/read/27843660/low-grade-appendiceal-mucinous-neoplasm-involving-the-endometrium-and-presenting-with-mucinous-vaginal-discharge
#11
Vera Vavinskaya, Joel M Baumgartner, Albert Ko, Cheryl C Saenz, Mark A Valasek
Primary appendiceal mucinous lesions are uncommon and represent a spectrum from nonneoplastic mucous retention cysts to invasive adenocarcinoma. Low-grade appendiceal mucinous neoplasms (LAMNs) represent an intermediate category on this spectrum and can be classified according to whether or not they are confined to the appendix. Although LAMNs are frequently confined to the appendix, they can also spread to the peritoneum and clinically progress as pseudomyxoma peritonei (i.e., mucinous ascites). Thus, the appropriate classification of appendiceal primary neoplasia is essential for prognosis and influences clinical management...
2016: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27835997/adenocarcinoma-mimicking-appendicular-lump-a-diagnostic-dilemma-a-case-report
#12
Sanket Kalpande, Jayashri Pandya, Tushar Sharma
BACKGROUND: Primary appendiceal adenocarcinoma is a rare tumor, mucinous variety being common. This case is reported to highlight the unusual presentation and diagnostic difficulty of appendiceal adenocarcinoma. CASE PRESENTATION: Patient presented with acute appendicitis with ill-defined tender lump which responded to conservative management. CONCLUSIONS: High index of suspicion should be kept in mind for elderly patients presenting with appendicular lump...
November 11, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27830037/goblet-cell-carcinoids-of-the-appendix-tumor-biology-mutations-and-management-strategies
#13
REVIEW
Santosh Shenoy
Malignant neoplasms of the appendix are rare and represent less than 1% of gastrointestinal cancers. Goblet cell carcinoids (GCC) tumors are a distinctive group of heterogeneous appendiceal neoplasm that exhibit unique clinical and pathologic features. This review focuses on the current diagnostic procedures, pathogenesis, possible signaling mechanisms and treatment options for GCC. Perspectives for future research are discussed. The tumor likely arises from pluripotent intestinal epithelial crypt base stem cells...
October 27, 2016: World Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/27822629/ultimate-clinical-outcomes-of-appendiceal-mucinous-neoplasm-of-uncertain-malignant-potential
#14
Rumi Shin, Young Jun Chai, Ji Won Park, Mee Soo Chang, Jeong Mo Bae, Min Jung Kim, Byung Kwan Park, Kyu Joo Park, Seung-Yong Jeong
BACKGROUND: The clinical outcome of appendiceal mucinous neoplasm (AMN) is not well understood. This study aimed to compare the long-term outcome for the uncertain malignant potential (UMP) subtype of AMNs with those of the mucinous adenoma (MA) and mucinous adenocarcinoma (MAC) subtypes. METHODS: In this study, AMNs were classified into three groups (MA, UMP, and MAC), and clinical characteristics, overall survival (OS), and progression-free survival (PFS) were compared among the three groups...
November 7, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27811127/collet-sicard-syndrome-a-rare-but-important-presentation-of-internal-jugular-vein-thrombosis
#15
Shermyn Neo, Kim En Lee
We describe a rare neurological presentation of internal jugular vein thrombosis induced by central venous catheter placement in a patient with cancer. A 71-year-old man gave a 3-week history of dysphagia and dysarthria with left-sided neck pain and headache. He was receiving chemotherapy for appendiceal adenocarcinoma. On examination, he had left 9th-12th cranial neuropathies, manifesting as voice hoarseness, decreased palatal movement, absent gag reflex, weakness of scapular elevation and left-sided tongue wasting...
January 2017: Practical Neurology
https://www.readbyqxmd.com/read/27802196/prognostic-factors-for-survival-in-advanced-appendiceal-cancers
#16
Fatima Khan, Rachel I Vogel, Gustave K Diep, Todd M Tuttle, Emil Lou
BACKGROUND: Appendiceal cancer is a rare malignancy. The optimal pathologic classification and prognostic factors for survival and treatment strategies remain poorly understood. OBJECTIVE: The aim of this retrospective cohort study was to determine prognostic factors, including markers of systemic inflammation, for survival in a cohort of patients with advanced appendiceal adenocarcinomas. METHODS: The study included patients with advanced appendiceal carcinoma that were treated between January 2006 and June 2012...
September 30, 2016: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/27784975/limited-local-extracolonic-spread-of-mucinous-appendiceal-adenocarcinoma-after-perforation-with-formation-of-a-malignant-appendix-to-sigmoid-fistula-case-report-and-literature-review
#17
Seifeldin Hakim, Mitual Amin, Mitchell S Cappell
A 68-year-old man presented with progressive right lower quadrant abdominal pain and tenderness without rebound tenderness, and with constipation during the prior 9 mo. Abdomino-pelvic computed tomography and magnetic resonance imaging demonstrated a dilated appendix forming a fistula to the sigmoid colon. Open laparotomy revealed a bulky abdominal tumor involving appendix, cecum, and sigmoid, and extending up to adjacent viscera, without ascites or peritoneal implants. The abdominal mass was removed en bloc, including resection of sigmoid colon, cecum (with preservation of ileocecal valve), appendix, right vas deferens, testicular vessels, and minimal amounts of anterior abdominal wall; and shaving off of small parts of the walls of the urinary bladder and small bowel...
October 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27770344/when-and-when-not-to-perform-a-right-colon-resection-with-mucinous-appendiceal-neoplasms
#18
Paul H Sugarbaker
BACKGROUND: Mucinous appendiceal neoplasms (MAN) with peritoneal dissemination is treated as a standard of care using cytoreductive surgery and hyperthermic perioperative chemotherapy. The extent of the resection of peritoneal surfaces and visceral structures is generally well defined. Exception to this consensus regarding structures to be removed are the right colon and adjacent ileocolic lymph nodes. METHODS: From a prospectively maintained database, all patients with a histologic diagnosis of peritoneal mucinous carcinoma (PMCA) who underwent complete cytoreductive surgery were assessed for the presence versus absence of adenocarcinoma in lymph nodes within the appendiceal mesentery and/or in the lymph nodes of the ileocolic group...
March 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27595862/elevated-risk-of-subsequent-malignancies-in-patients-with-appendiceal-cancer-a-population-based-analysis
#19
Adil Ayub, Om Parkash, Norberto Santana-Rodríguez, Wissam Raad, Faiz Y Bhora
BACKGROUND: Appendiceal cancer is extremely rare with excellent survival after curative resection. There is a concern for the development of additional cancers in survivors of appendiceal cancer. However, existing data is limited to small anecdotal reports on appendiceal carcinoid only. We aim to investigate the risk of subsequent malignancies in patients with appendiceal carcinoma and correlate the risk according to patient and clinical characteristics. METHODS: We identified 3788 patients with appendiceal cancer from the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) database between 1992 and 2011...
September 2016: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/27583883/contrast-enhanced-ultrasound-improves-accurate-identification-of-appendiceal-mucinous-adenocarcinoma-in-an-old-patient-a-case-report
#20
Jing Shang, Li-Tao Ruan, Ying Dang, Yun-Yue Wang, Yan Song, Jie Lian
BACKGROUND: Adenocarcinoma of appendiceal origin is far rarer than other colorectal carcinomas and its preoperative diagnosis is challenging. To our knowledge, utility of contrast-enhanced ultrasound (CEUS) to diagnose it is much less. METHOD: A 61-year-old man presented with abdominal pain in the right lower quadrant for 20 days. In order to fulfill an accurately preoperative diagnosis, he received laboratory and imaging tests such as carcinoembryonic antigen (CEA), computer tomography (CT), CEUS and endoscope...
August 2016: Medicine (Baltimore)
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