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Low grade appendiceal mucinous neoplasm

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https://www.readbyqxmd.com/read/29159742/validation-of-the-recent-psogi-pathological-classification-of-pseudomyxoma-peritonei-in-a-single-center-series-of-265-patients-treated-by-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy
#1
Dario Baratti, Shigeki Kusamura, Massimo Milione, Federica Bruno, Marcello Guaglio, Marcello Deraco
BACKGROUND: Controversies still persist regarding the terminology and pathologic classification of appendiceal mucinous neoplasms and associated pseudomyxoma peritonei (PMP). We assessed reproducibility and prognostic significance of the classification recently proposed by the Peritoneal Surface Oncology Group International (PSOGI). METHODS: A prospective database of 265 PMP patients uniformly treated by cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) from 1995 to 2017 was reviewed...
November 20, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29098385/incidental-appendectomy-during-robotic-laparoscopic-prostatectomy-safe-and-worth-to-perform
#2
C Hüttenbrink, G Hatiboglu, T Simpfendörfer, J P Radtke, R Becker, D Teber, B Hadaschik, S Pahernik, M Hohenfellner
PURPOSE: The purpose of this study is to investigate the safety and patients' benefit of incidental appendectomy during robot-assisted laparoscopic radical prostatectomy (RALRP). METHODS: Fifty-three patients, who had incidental appendectomy during RALRP between January 2012 and March 2014, were enrolled to this study. To evaluate the safety of the procedure, following parameters were evaluated: patient age, duration of surgery, perioperative complications (classified by Clavien-Dindo), time to bowel movement, and length of hospital stay...
November 2, 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/28993033/ca-19-9-to-peritoneal-carcinomatosis-index-pci-ratio-is-prognostic-in-patients-with-epithelial-appendiceal-mucinous-neoplasms-and-peritoneal-dissemination-undergoing-cytoreduction-surgery-and-intraperitoneal-chemotherapy-a-retrospective-cohort-study
#3
Mathew A Kozman, Oliver M Fisher, Bree-Anne J Rebolledo, Sarah J Valle, Nayef Alzahrani, Winston Liauw, David L Morris
BACKGROUND: Serum tumour levels have been shown to be prognostic in patients with epithelial appendiceal mucinous neoplasms with peritoneal dissemination (pseudomyxoma peritonei (PMP)). A singular index which incorporates both tumour activity (as depicted by serum tumour marker levels) and tumour volume (as depicted by peritoneal carcinomatosis index (PCI)), may give a more precise surrogate of tumour biological behaviour. The prognostic implication of this index has not yet been reported...
September 19, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28988021/two-concurrent-appendiceal-neoplasms-in-an-elderly-patient-a-case-report
#4
Riva Das, Joshua P Cantor, Thai Q Vu
INTRODUCTION: Acute appendicitis, one of the commonest surgical diagnoses, is rare and more complex presentation in the elderly. Physicians must consider atypical causes appendicitis in this population, which could affect the management of the patient. PRESENTATION OF CASE: An elderly female presented with a two-day history of lower abdominal pain, associated with low-grade fevers and chills. Studies showed leukocytosis and computed tomography (CT) findings consistent with appendicitis...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28975983/hiv-patient-with-pseudomyxoma-peritonei-of-extra-appendiceal-origin-is-disease-free-and-alive-9-years-after-complete-cytoreductive-surgery
#5
A Tampakis, E C Tampaki, P Alexandrou, K Kontzoglou, G Kouraklis
OBJECTIVE: Pseudomyxoma peritonei (PMP) is a clinical syndrome that is mainly characterized by the presence of mucinous ascites that results from the rupture of a mucin-producing neoplasm. No reports exist so far regarding the management of this syndrome in HIV patients. CASE REPORT: A 54-year old male patient with a diagnosed atypical colitis developed additionally over time a complicated diverticulitis which was initially treated conservatively with antibiotics...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28970138/grading-and-staging-mucinous-neoplasms-of-the-appendix-a-case-series-and-review-of-the-literature
#6
Sarah E Umetsu, Nafis Shafizadeh, Sanjay Kakar
The grading and staging of appendiceal mucinous neoplasms is challenging and fraught with terminology problems, but has critical prognostic and therapeutic implications. We utilized a small case series to examine the grading and staging systems of appendiceal mucinous neoplasms and outline the evidence for the new systems proposed in the upcoming 8th edition of the American Joint Committee on Cancer (AJCC) Staging Manual. We reviewed 33 cases of appendiceal mucinous neoplasms with available clinical follow-up data, 6 of which were widely disseminated in the peritoneum...
September 29, 2017: Human Pathology
https://www.readbyqxmd.com/read/28746986/the-histopathological-classification-diagnosis-and-differential-diagnosis-of-mucinous-appendiceal-neoplasms-appendiceal-adenocarcinomas-and-pseudomyxoma-peritonei
#7
REVIEW
Norman J Carr, Frederic Bibeau, Robert F Bradley, Peggy Dartigues, Roger M Feakins, Kim R Geisinger, Xianyong Gui, Sylvie Isaac, Massimo Milione, Joseph Misdraji, Reetesh K Pai, Manuel Rodriguez-Justo, Leslie H Sobin, Marie-Louise F van Velthuysen, Rhonda K Yantiss
The vermiform appendix is the primary site of several distinctive benign and malignant neoplasms. Some can produce the clinical syndrome of pseudomyxoma peritonei (PMP). A consensus on their terminology was reached by an international panel of pathologists and clinicians working under the auspices of the Peritoneal Surface Oncology Group International (PSOGI), and this review discusses the application of the PSOGI classification to routine reporting. We discuss diagnosis and differential diagnosis together with implications for patient management, covering low-grade appendiceal mucinous neoplasms, high-grade appendiceal mucinous neoplasms, serrated polyps, adenomas and adenocarcinomas...
December 2017: Histopathology
https://www.readbyqxmd.com/read/28730790/perioperative-systemic-chemotherapy-for-peritoneal-mucinous-appendiceal-carcinomas-treated-with-cytoreductive-surgery-hipec
#8
John Spiliotis, Nikolaos Kopanakis, Elias Efstathiou, Dimitra Vassiliadou, Orestis Argiriou, Athanassios Rogdakis, Christos Valavanis
PURPOSE: To identify the role of systemic chemotherapy in the management of appendiceal malignancies. METHODS: Over a 10-year period (2005 -2014), 52 patients with appendiceal neoplasms were treated at our Peritoneal Surface Malignancy Unit [14 (26.9%) disseminated peritoneal adenomucinosis (DPAM), 30 (57.7%) peritoneal mucinous carcinomatosis of appendiceal origin (PMCA) and 8 (15.4%) PMCA-I]. All patients (100%) underwent cytoreductive surgery (CRS) & hyperthermic intraperitoneal chemotherapy (HIPEC), while 20 (38...
May 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28679331/predictive-value-of-peritoneal-cancer-index-for-survival-in-patients-with-mucinous-peritoneal-malignancies-treated-with-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-a-single-centre-experience
#9
Andreas Brandl, Sascha Weiss, Moritz von Winterfeld, Alexander Krannich, Mathilde Feist, Johann Pratschke, Wieland Raue, Beate Rau
OBJECTIVES: This study investigated the correlation between the peritoneal carcinomatosis index (PCI) and patient outcome depending on the tumour type. BACKGROUND: Peritoneal surface malignancy (PSM) treatment depends on tumour type. Mucinous PSM (m-PSM) is associated with a better prognosis than non-mucinous PSM (nm-PSM). The PCI's predictive ability has not yet been evaluated. METHODS: We analysed 123 patients with PSM treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) between 2008 and 2015...
July 26, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28663356/appendiceal-mucinous-neoplasms-diagnosis-and-management
#10
REVIEW
Walid L Shaib, Rita Assi, Ali Shamseddine, Olatunji B Alese, Charles Staley, Bahar Memis, Volkan Adsay, Tonios Bekaii-Saab, Bassel F El-Rayes
OBJECTIVE: Appendiceal mucinous neoplasms (AMNs) are a rare and heterogeneous disease for which clinical management is challenging. We aim to review the literature regarding modalities of treatment to guide the management of AMNs. METHODS AND REVIEW CRITERIA: We conducted a PubMed search in February 2016 for English-language publications, using the terms "appendiceal," "appendix," "carcinoma," "cancer," "mucinous," "treatment," "genes," "target," "genomic," and terms listed in the articles' subheadings...
September 2017: Oncologist
https://www.readbyqxmd.com/read/28655402/mucinous-appendiceal-neoplasms-incidence-diagnosis-and-surgical-treatment
#11
Oana Anisa Nutu, Alberto A Marcacuzco Quinto, Alejandro Manrique Municio, Iago Justo Alonso, Jorge Calvo Pulido, María García-Conde, Félix Cambra Molero, Luis Carlos Jiménez Romero
INTRODUCTION: Mucinous tumors of the appendix are a rare pathology, with a prevalence below 0.5%. Clinical presentation usually occurs during the sixth decade of life, and mucinous tumors can clinically mimic acute appendicitis. The aim of this study is to describe the clinical and demographic variables, therapeutic procedure and diagnosis of these tumors. We analyze the association between mucinous tumors and pseudomyxoma peritonei (PP), as well as the association with colorectal and ovarian tumors...
June 2017: Cirugía Española
https://www.readbyqxmd.com/read/28599482/an-unusual-case-of-pseudomyxoma-peritonei-associated-with-synchronous-primary-mucinous-tumors-of-the-ovary-and-appendix-a-case-report
#12
Dong Soo Suh, Yong Jung Song, Byung Su Kwon, Sul Lee, Nam Kyung Lee, Kyung Un Choi, Ki Hyung Kim
Pseudomyxoma peritonei (PMP) is a rare disease that usually originates from mucinous neoplasms of the appendix and, less commonly, from extra-appendiceal tumors, but it may also be caused by synchronous primary mucinous tumors of the ovary and appendix. The current study discusses the case of a 73-year-old female who presented with progressively worsening indigestion and abdominal distension. Magnetic resonance imaging of the pelvis revealed a large cystic mass with a thin enhancing septa arising from the right ovary and ascites with scalloping of the liver surface...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28591173/overinterpretation-is-common-in-pathological-diagnosis-of-appendix-cancer-during-patient-referral-for-oncologic-care
#13
Mark A Valasek, Irene Thung, Esha Gollapalle, Alexey A Hodkoff, Kaitlyn J Kelly, Joel M Baumgartner, Vera Vavinskaya, Grace Y Lin, Ann P Tipps, Mojgan V Hosseini, Andrew M Lowy
CONTEXT: Low-grade appendiceal mucinous neoplasm (LAMN) and appendiceal adenocarcinoma are known to cause the majority of pseudomyxoma peritonei (PMP, i.e. mucinous ascites); however, recognition and proper classification of these neoplasms can be difficult despite established diagnostic criteria. OBJECTIVE: To determine the pathological diagnostic concordance for appendix neoplasia and related lesions during patient referral to an academic medical center specialized in treating patients with PMP...
2017: PloS One
https://www.readbyqxmd.com/read/28526814/kras-and-gnas-co-mutation-in-metastatic-low-grade-appendiceal-mucinous-neoplasm-lamn-to-the-ovaries-a-practical-role-for-next-generation-sequencing
#14
Daniel R Matson, Jin Xu, Laura Huffman, Lisa Barroilhet, Molly Accola, William M Rehrauer, Paul Weisman
BACKGROUND Low-grade appendiceal mucinous neoplasms (LAMNs) are cytologically low-grade tumors of the appendix and are a frequent cause of pseudomyxoma peritonei. They can become a diagnostic challenge when they metastasize to the ovaries, where they may mimic primary ovarian mucinous tumors. CASE REPORT We report the case of a patient with very large bilateral ovarian mucinous tumors and a concurrent minute LAMN incidentally discovered in a grossly normal appendix. A primary ovarian tumor was suspected, but histological analysis of the ovaries suggested an appendiceal origin...
May 20, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28474197/computed-tomography-follow-up-assessment-of-patients-with-low-grade-appendiceal-mucinous-neoplasms-evaluation-of-risk-for-pseudomyxoma-peritonei
#15
Catarina Tiselius, Csaba Kindler, Jayant Shetye, Henry Letocha, Kenneth Smedh
BACKGROUND: Low-grade appendiceal mucinous neoplasms are rare. Both classification and management vary. This study aimed to follow up on patients with a diagnosis of LAMN after primary surgery with computer tomography (CT) scans to examine the risk for the development of pseudomyxoma peritonei (PMP). METHODS: This population-based prospective study investigated patients who underwent appendectomy between 2007 and 2013 and had histology results demonstrating the presence of LAMN...
July 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28286683/low-grade-appendiceal-mucinous-neoplasm-presenting-as-an-adnexal-mass
#16
P Panagopoulos, T Tsokaki, E Misiakos, V Domi, C Christodoulaki, D Sioutis, N Papantoniou
Appendiceal tumors are rare, late diagnosed neoplasms that may not be differentiated from adnexal masses even by advanced imaging methods and other diagnostic procedures. They may be asymptomatic and remain undiagnosed until surgery. We report a case of an 80-year-old postmenopausal woman presenting with a pelvic mass and a history of weight loss. The patient underwent laparotomy which revealed an appendiceal mucocele, for which she received a full oncological procedure. The histology report showed a low-grade appendiceal mucinous neoplasm, and the patient underwent six cycles of chemotherapy...
2017: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28267002/histological-subtype-remains-a-significant-prognostic-factor-for-survival-outcomes-in-patients-with-appendiceal-mucinous-neoplasm-with-peritoneal-dissemination
#17
Yeqian Huang, Nayef A Alzahrani, Terence C Chua, David L Morris
BACKGROUND: It has been increasingly recognized that appendiceal mucinous neoplasm with peritoneal dissemination is not a homogenous disease. OBJECTIVE: This study aimed to examine the impact of different histological subtypes on survival of a large cohort of patients with appendiceal mucinous neoplasms uniformly treated by cytoreductive surgery and intraperitoneal chemotherapy. DESIGN: This was a retrospective study of prospectively collected data of patients with peritoneal dissemination of appendiceal neoplasm who underwent cytoreductive surgery and intraperitoneal chemotherapy...
April 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28192848/low-grade-appendiceal-mucinous-neoplasm-lamn-3-year-endoscopic-follow-up-underlines-benign-course-of%C3%A2-lamn-type-1
#18
Thomas Klag, Jan Wehkamp, Hans Bösmüller, Claudius Falch, Jonas Johannink, Nisar P Malek, Andreas Kirschniak, Martin Goetz
Low-grade appendiceal mucinous neoplasms (LAMNs) are neoplastic lesions with potential progression to pseudomyxoma peritonei (PMP). In most cases, diagnosis is made because of suspected acute appendicitis or incidentally by computed tomography (CT). However, incidental diagnosis during colonoscopy is rare. We present the case of a 63-year-old man with a LAMN type 1 lesion, diagnosed at routine colonoscopy for surveillance of ulcerative colitis. Because in earlier surveillance colonoscopies, this lesion was misinterpreted as fecal polution, for the first time, this case describes retrospectively a 3-year endoscopic follow-up of LAMN type 1, underlining the benign course of these kind of lesions compared to type 2 lesions with submucosal infiltration...
February 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/28133311/-a-case-of-appendiceal-mucinous-cystadenoma-treated-using-laparoscopic-appendectomy
#19
Daiki Marukawa, Shingo Noura, Harunobu Yasuyama, Tae Matsumura, Chikato Koga, Akihiro Takata, Chizu Kameda, Masahiro Murakami, Ryohei Kawabata, Masaki Hirota, Junzo Shimizu, Hideaki Miwa, Junichi Hasegawa
A 73 year-old woman who was treated for breast cancer and visited our hospital regularly was suspected of having a mucinous cystadenoma of the appendix. Malignancy could not be determined using abdominal computed tomography, magnetic resonance imaging, or colonoscopy. Even if mucinous cystadenoma is benign, there is the possibility that the tumor will rupture, discharge its contents, and cause pseudomyxoma peritonei. We performed laparoscopic appendectomy. According to the histopathological results, the tumor was diagnosed as a low grade appendiceal mucinous neoplasm...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133251/-a-giant-appendiceal-mucinous-neoplasm-treated-with-laparoscopic-surgery
#20
Yoshito Nako, Shigeki Yamazaki, Takashi Kitade, Tomoki Hariu, Motomi Wakasa, Masayoshi Nakanishi, Teruhisa Sonoyama
We encountered a case of giant appendiceal mucinous neoplasm that was treated with laparoscopic surgery. The patient was a 77-year-old man with constipation. Lower endoscopy demonstrated a giant SMT-like tumor in the cecum, and abdominal computed tomography revealed a giant appendiceal mucinous neoplasm and nearby lymph nodes swelling. Hematological examination showed an elevated serum CEA level. We performed laparoscopic ileocecal resection for a definite diagnosis and treatment. The postoperative course was uneventful...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
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