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Goblet cell carcinoid

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https://www.readbyqxmd.com/read/28808504/goblet-cell-carcinoid-of-the-appendix-and-mixed-adenoneuroendocrine-carcinoma-report-of-three-cases
#1
Hatice Karaman, Fatma Şenel, Mustafa Güreli, Turan Ekinci, Ömer Topuz
Neuroendocrine neoplasms are the most common epithelial tumors among appendix tumors. Appendix tumors that are completely or partially composed of neuroendocrine cells are divided into two categories: Classic carcinoid tumors and goblet cell carcinoid tumors (GCCT). They are known to progress more aggressively than classic (neuro) endocrine tumors. In this study, three cases with acute appendicitis symptoms are presented, including their clinical and histopathological findings. Microscopic examination detected GCCT in two cases and mixed adenoneuroendocrine carcinoma in one case, in addition to acute appendicitis...
July 15, 2017: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28761642/frequency-characteristics-and-outcomes-of-appendicular-neuroendocrine-tumors-a-cross-sectional-study-from-an-academic%C3%A2-tertiary-care-hospital
#2
Abdelrahman Abdelaal, Walid El Ansari, Issam Al-Bozom, Mahwish Khawar, Fakhar Shahid, Ammar Aleter, Mohammed Rasoul Abunuwar, Ayman El-Menyar
BACKGROUND: Appendicular neuroendocrine tumors (NET, Carcinoid tumors) of the appendix are rare and mostly diagnosed incidentally on the post-operative histopathological examination. NET are usually associated with good 5-year survival rates. We aimed to assess our experience for the diagnosis and management of NET over 11 years. METHOD: It is a retrospective chart review of all clinically suspected patients with acute appendicitis who underwent emergent appendectomy with intention to treat between January 2004-December 2014, and were clinically followed up until 2016...
September 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28659644/are-goblet-cell-carcinoids-a-group-of-heterogeneous-tumors
#3
Jirka Macak, Kristina Nemejcova, Jana Dvorackova
BACKGROUND: Goblet cell carcinoids belong to neuroendocrine tumors, according to the WHO classification. The tumors are diagnosed based on a typical histological pattern and using neuroendocrine markers. However, some tumors do not react with these markers and yet expression of proliferative markers is high. Do these tumors belong to G1 and G2 neuroendocrine tumors? METHODS: The sample comprised nine cases of tumors of the appendix identified by immunohistological methods as goblet cell carcinoids or adenocarcinoma ex goblet cell carcinoid...
June 12, 2017: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/28551326/appendiceal-goblet-cell-carcinoid-common-errors-in-staging-and-clinical-interpretation-with-a-proposal-for-an-improved-terminology
#4
Kwun Wah Wen, Gillian Hale, Nafis Shafizadeh, Mojgan Hosseini, Anne Huang, Sanjay Kakar
Goblet cell carcinoid (GCC) is staged and treated as adenocarcinoma (AC) and not as neuroendocrine tumor (NET) or neuroendocrine carcinoma. The term 'carcinoid' may lead to incorrect interpretation as NET. To explore pitfalls in staging and clinical interpretation of GCC and mixed GCC-AC, and propose strategies to avoid common errors. Diagnostic terminology, staging and clinical interpretation were evaluated in 58 cases (27 GCC, 31 mixed GCC-AC). Opinions were collected from 23 pathologists using a survey. Clinical notes were reviewed to assess the interpretation of pathology diagnoses by oncologists...
May 24, 2017: Human Pathology
https://www.readbyqxmd.com/read/28463910/diffusely-metastasized-adenocarcinoma-arising-in-a-mucinous-carcinoid-of-the-ovary-a-case-report
#5
Anne-Sophie Van Rompuy, Adriaan Vanderstichele, Ignace Vergote, Philippe Moerman
Mucinous (goblet cell) carcinoids are a rare type of ovarian carcinoid tumors. Only a limited number of primary mucinous carcinoids of the ovary have been reported in the literature. We describe the case of a 55-year-old woman with a diffusely metastasized adenocarcinoma arising in a primary ovarian mucinous carcinoid. The differential diagnosis with a metastatic goblet cell carcinoid from the appendix or elsewhere can be very challenging. In our case, especially the immunohistochemical profile of the tumor with diffuse positivity for cytokeratin 7 and PAX8, and no expression of cytokeratin 20 and CDX2, directed us toward a primary ovarian origin...
April 29, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28449607/adenocarcinoma-ex-goblet-cell-carcinoid-of-the-appendix-with-metastatic-peritoneal-spread-to-meckel-s-diverticulum-and-endometriosis
#6
Brett Matthew Lowenthal, Grace Y Lin, Ann M Ponsford Tipps, Mojgan Hosseini
Adenocarcinoma ex-goblet cell carcinoid is a very rare and histologically unique appendiceal malignancy with dual glandular and neuroendocrine differentiation. There is a high incidence of this tumor among middle-aged women with metastasis to the gynecologic tract with the mode of metastasis following peritoneal spread rather than hematogenous distribution. Adenocarcinoma ex-goblet cell carcinoid can spread to any peritoneal site including ovaries or omentum. We report a 37-year-old healthy woman who initially presented with right lower quadrant abdominal pain and pseudomyxoma peritonei...
April 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28302663/amyand-s-hernia-containing-an-appendiceal-goblet-cell-carcinoid-tumour
#7
Zarif Yahya, Chien-I Wang, Boon Hong
Amyand's hernia is a rare occurrence where the appendix is trapped within an inguinal hernia. Appendicitis within the hernia is even rarer. However, the presence of an appendiceal neoplasm in an inguinal hernia is almost unheard of with only two cases reported in the literature. We present an extremely rare case of an inflamed appendix within an Amyand's hernia, which was found to be a goblet cell type carcinoid tumour requiring further oncological resection and treatment.
March 16, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28283864/lower-gastrointestinal-neuroendocrine-neoplasms-associated-with-hereditary-cancer-syndromes-a-case-series
#8
Trilokesh D Kidambi, Christina Pedley, Amie Blanco, Emily K Bergsland, Jonathan P Terdiman
Lower gastrointestinal (GI) neuroendocrine neoplasms (NENs) of the colon and rectum are uncommon and not traditionally associated with hereditary GI cancer syndromes. However, with widespread implementation of colorectal cancer screening programs, lower GI NENs are being identified with increasing frequency. We report the first case series of six patients with lower GI NENs who were diagnosed with hereditary GI cancer syndromes by germline testing. Two patients presented with poorly differentiated rectal neuroendocrine carcinoma (NECs) with colonic polyposis and were found to have Familial Adenomatous Polyposis and MYH-Associated Polyposis, respectively...
March 10, 2017: Familial Cancer
https://www.readbyqxmd.com/read/28280620/potential-actionable-targets-in-appendiceal-cancer-detected-by-immunohistochemistry-fluorescent-in-situ-hybridization-and-mutational-analysis
#9
Erkut Borazanci, Sherri Z Millis, Jeffery Kimbrough, Nancy Doll, Daniel Von Hoff, Ramesh K Ramanathan
BACKGROUND: Appendiceal cancers are rare and consist of carcinoid, mucocele, pseudomyxoma peritonei (PMP), goblet cell carcinoma, lymphoma, and adenocarcinoma histologies. Current treatment involves surgical resection or debulking, but no standard exists for adjuvant chemotherapy or treatment for metastatic disease. METHODS: Samples were identified from approximately 60,000 global tumors analyzed at a referral molecular profiling CLIA-certified laboratory. A total of 588 samples with appendix primary tumor sites were identified (male/female ratio of 2:3; mean age =55)...
February 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28211016/adenocarcinoma-ex-goblet-cell-carcinoid-of-the-appendix-a-case-report-and-overview-of-the-disease
#10
Uroosa Ibrahim, Gautam Valecha, Gwenalyn Garcia, Amina Saqib, Monika Wrzolek, Meekoo Dhar
No abstract text is available yet for this article.
February 17, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/28193185/intestinal-goblet-cell-carcinoid-presenting-with-recurrent-sterile-peritonitis-in-a-patient-on-peritoneal-dialysis-a-case-report
#11
Chih-Wei Chen, Jan-Show Chu, Li-Chun Hsieh, Chih-Chin Kao, Yen-Chung Lin, Hsi-Hsien Chen
BACKGROUND: Goblet cell carcinoid is a rare variant of appendiceal carcinoid with mixed endocrine and exocrine features. The most common symptom and signs are abdominal pain, acute appendicitis and palpable mass. Additionally, abdominal pain is common in patient on peritoneal dialysis, which may confound the diagnosis in such patient. CASE PRESENTATION: We report a 71- years- old woman on peritoneal dialysis that experienced several episodes of abdominal cramping pain and sterile peritonitis...
February 13, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28133078/-a-case-of-curatively-resected-goblet-cell-carcinoid-of-the-appendix-diagnosed-via-intraoperative-frozen-sectional-examination
#12
Tomoya Ikeda, Junichiro Yamauchi, Kento Miyazaki, Sho Yasuta, Shota Fujita, Mamoru Satoh, Keiichi Shirasaki, Shin Kobayashi, Takashi Ajiki, Katsuo Tsuchihara, Noriko Kondo, Shuichi Ishiyama
A 52-year-old patient presented with epigastric pain.An enhanced CT scan showed a strongly enhanced appendix with abscess formation.Appendectomy was performed under the diagnosis of acute appendicitis with perityphlitic abscess.The stump of the appendix was white and hard, suggesting malignant transformation.Intraoperative frozen sectional examination indicated goblet cell carcinoid(GCC)of the appendix.Thereafter, we performed ileocecal resection with lymphadenectomy (D3).The final pathological diagnosis was GCC, pSS, pN1, Stage III a by the Japanese classification of colorectal carcinoma...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133074/-a-case-of-goblet-cell-carcinoid-of-the-appendix-invading-directly-into-the-sigmoid-colon
#13
Satoru Matsumoto, Masahiro Takahashi, Shusaku Takahashi, Hideki Yamagami, Hiroyuki Ishizu
A 73-year-old man underwent a screening colonoscopy, and a depressed lesion in the sigmoid colon was detected. Biopsy revealed a Group V lesion, and he was diagnosed with sigmoid colon cancer. During surgery, there was dense adhesion of the appendix to the sigmoid colon, and sigmoidectomy combined with appendectomy was performed. However, pathological examination revealed goblet cell carcinoid of the appendix with direct invasion into the sigmoid colon. To the best of our knowledge, no similar cases have been reported in Japan...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/27922277/goblet-cell-carcinoid-of-the-ovary-a-case-report-with-ultrastructural-analysis
#14
Maria G Fiore, Roberta Rossi, Claudia Covelli, Vera Loizzi, Domenico Piscitelli, Gennaro Cormio
No abstract text is available yet for this article.
February 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27830037/goblet-cell-carcinoids-of-the-appendix-tumor-biology-mutations-and-management-strategies
#15
REVIEW
Santosh Shenoy
Malignant neoplasms of the appendix are rare and represent less than 1% of gastrointestinal cancers. Goblet cell carcinoids (GCC) tumors are a distinctive group of heterogeneous appendiceal neoplasm that exhibit unique clinical and pathologic features. This review focuses on the current diagnostic procedures, pathogenesis, possible signaling mechanisms and treatment options for GCC. Perspectives for future research are discussed. The tumor likely arises from pluripotent intestinal epithelial crypt base stem cells...
October 27, 2016: World Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/27773125/synchronous-sessile-serrated-adenoma-and-goblet-cell-carcinoid-in-the-appendix-a-case-report-and-literature-review
#16
Zheqin R Lu, Phillip Jayasurya
No abstract text is available yet for this article.
February 2016: Pathology
https://www.readbyqxmd.com/read/27739441/non-ampullary-duodenal-carcinomas-clinicopathologic-analysis-of-47-cases-and-comparison-with-ampullary-and-pancreatic-adenocarcinomas
#17
Yue Xue, Alessandro Vanoli, Serdar Balci, Michelle M Reid, Burcu Saka, Pelin Bagci, Bahar Memis, Hyejeong Choi, Nobuyike Ohike, Takuma Tajiri, Takashi Muraki, Brian Quigley, Bassel F El-Rayes, Walid Shaib, David Kooby, Juan Sarmiento, Shishir K Maithel, Jessica H Knight, Michael Goodman, Alyssa M Krasinskas, Volkan Adsay
Literature on non-ampullary-duodenal carcinomas is limited. We analyzed 47 resected non-ampullary-duodenal carcinomas. Histologically, 78% were tubular-type adenocarcinomas mostly gastro-pancreatobiliary type and only 19% pure intestinal. Immunohistochemistry (n=38) revealed commonness of 'gastro-pancreatobiliary markers' (CK7 55, MUC1 50, MUC5AC 50, and MUC6 34%), whereas 'intestinal markers' were relatively less common (MUC2 36, CK20 42, and CDX2 44%). Squamous and mucinous differentiation were rare (in five each); previously, unrecognized adenocarcinoma patterns were noted (three microcystic/vacuolated, two cribriform, one of comedo-like, oncocytic papillary, and goblet-cell-carcinoid-like)...
February 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27595862/elevated-risk-of-subsequent-malignancies-in-patients-with-appendiceal-cancer-a-population-based-analysis
#18
Adil Ayub, Om Parkash, Norberto Santana-Rodríguez, Wissam Raad, Faiz Y Bhora
BACKGROUND: Appendiceal cancer is extremely rare with excellent survival after curative resection. There is a concern for the development of additional cancers in survivors of appendiceal cancer. However, existing data is limited to small anecdotal reports on appendiceal carcinoid only. We aim to investigate the risk of subsequent malignancies in patients with appendiceal carcinoma and correlate the risk according to patient and clinical characteristics. METHODS: We identified 3788 patients with appendiceal cancer from the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) database between 1992 and 2011...
September 2016: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/27401448/curative-surgical-resection-as-a-component-of-multimodality-therapy-for-peritoneal-metastases-from-goblet-cell-carcinoids
#19
Michal Radomski, Reetesh K Pai, Yongli Shuai, Lekshmi Ramalingam, Heather Jones, Matthew P Holtzman, Steven A Ahrendt, James F Pingpank, Herbert J Zeh, David L Bartlett, Haroon A Choudry
BACKGROUND: The impact of histopathologic features on oncologic outcomes for patients with peritoneal metastases from goblet cell carcinoid (GCC) undergoing multimodality therapy, including cytoreductive surgery with hyperthermic intraperitoneal chemoperfusion (CRS-HIPEC), is unknown. METHODS: This study prospectively analyzed 43 patients with GCC undergoing CRS-HIPEC between 2005 and 2013. Pathology slides were re-reviewed to classify GCC into histologic subtypes according to the Tang classification...
July 11, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27379210/appendiceal-mixed-adeno-neuroendocrine-carcinoma-a-population-based-study-of-the-surveillance-epidemiology-and-end-results-registry
#20
Shayna Brathwaite, Martha M Yearsley, Tanios Bekaii-Saab, Lai Wei, Carl R Schmidt, Mary E Dillhoff, Wendy L Frankel, John L Hays, Christina Wu, Sherif Abdel-Misih
INTRODUCTION: Mixed adeno-neuroendocrine carcinoma (MANEC) is a rare pathological diagnosis recently defined by the World Health Organization (WHO) in 2010. Prior to the definition by the WHO, tumors with both adenocarcinoma and neuroendocrine components were given multiple pathological designations making it difficult to characterize the disease. The aim of our study is to better characterize MANEC to better understand its natural history to influence patient care and positively impact outcomes...
2016: Frontiers in Oncology
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