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Appendiceal mucinous neoplasm

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https://www.readbyqxmd.com/read/28192848/low-grade-appendiceal-mucinous-neoplasm-lamn-3-year-endoscopic-follow-up-underlines-benign-course-of%C3%A2-lamn-type-1
#1
Thomas Klag, Jan Wehkamp, Hans Bösmüller, Claudius Falch, Jonas Johannink, Nisar P Malek, Andreas Kirschniak, Martin Goetz
Low-grade appendiceal mucinous neoplasms (LAMNs) are neoplastic lesions with potential progression to pseudomyxoma peritonei (PMP). In most cases, diagnosis is made because of suspected acute appendicitis or incidentally by computed tomography (CT). However, incidental diagnosis during colonoscopy is rare. We present the case of a 63-year-old man with a LAMN type 1 lesion, diagnosed at routine colonoscopy for surveillance of ulcerative colitis. Because in earlier surveillance colonoscopies, this lesion was misinterpreted as fecal polution, for the first time, this case describes retrospectively a 3-year endoscopic follow-up of LAMN type 1, underlining the benign course of these kind of lesions compared to type 2 lesions with submucosal infiltration...
February 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/28138447/diarrhea-concealing-a-duodenal-cecal-fistula-secondary-to-appendiceal-mucinous-neoplasm
#2
Su Aung, Amanda Cheung, Charlene Prather, Jinping Lai
Primary mucinous adenocarcinoma of the appendix is a rare gastrointestinal malignancy. Fistulous tract formation is a complication that is cited in literature. An 85-year-old man with multiple comorbidities presented with several weeks of persistent non-bloody diarrhea. Laboratory work-up was non-diagnostic. Abdominal imaging with barium contrast showed an enterocolonic fistulous tract extending from the duodenum to the cecum involving an enlarged appendiceal mass. Subsequent biopsy confirmed mucinous appendiceal neoplasm with peritoneal spread to the liver and mesentery...
2017: ACG Case Reports Journal
https://www.readbyqxmd.com/read/28133311/-a-case-of-appendiceal-mucinous-cystadenoma-treated-using-laparoscopic-appendectomy
#3
Daiki Marukawa, Shingo Noura, Harunobu Yasuyama, Tae Matsumura, Chikato Koga, Akihiro Takata, Chizu Kameda, Masahiro Murakami, Ryohei Kawabata, Masaki Hirota, Junzo Shimizu, Hideaki Miwa, Junichi Hasegawa
A 73 year-old woman who was treated for breast cancer and visited our hospital regularly was suspected of having a mucinous cystadenoma of the appendix. Malignancy could not be determined using abdominal computed tomography, magnetic resonance imaging, or colonoscopy. Even if mucinous cystadenoma is benign, there is the possibility that the tumor will rupture, discharge its contents, and cause pseudomyxoma peritonei. We performed laparoscopic appendectomy. According to the histopathological results, the tumor was diagnosed as a low grade appendiceal mucinous neoplasm...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133251/-a-giant-appendiceal-mucinous-neoplasm-treated-with-laparoscopic-surgery
#4
Yoshito Nako, Shigeki Yamazaki, Takashi Kitade, Tomoki Hariu, Motomi Wakasa, Masayoshi Nakanishi, Teruhisa Sonoyama
We encountered a case of giant appendiceal mucinous neoplasm that was treated with laparoscopic surgery. The patient was a 77-year-old man with constipation. Lower endoscopy demonstrated a giant SMT-like tumor in the cecum, and abdominal computed tomography revealed a giant appendiceal mucinous neoplasm and nearby lymph nodes swelling. Hematological examination showed an elevated serum CEA level. We performed laparoscopic ileocecal resection for a definite diagnosis and treatment. The postoperative course was uneventful...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133104/-fourteen-cases-of-low-grade-appendiceal-mucinous-neoplasm
#5
Takuro Yoshikawa, Hiroki Sakamoto, Takahisa Akashi, Yu Asakura, Tetsuya Ienaga
Low-grade appendiceal mucinous neoplasm(LAMN)is a rare disease. In consideration of consistency with the 2010WHO Classification, LAMNwas classified in the Japanese Classification of Colorectal Carcinoma 8th edition. The present study involved 14 patients with LAMNover a 5-year period. The preoperative diagnosis was made as mucocele of the appendix in 9 cases. Operative interventions included ileocecal resection in 6 cases(laparoscopic; 3 cases)and appendectomy in 8 cases (laparoscopic; 6 cases). Histopathologically, there was no LNpositive case...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/27994008/mesothelial-inclusion-cyst-a-rare-occurrence
#6
David Sc Soon, Hamish Shilton, Ali Andrabi
Mesothelial inclusion cyst is a rare benign tumour that has only 130 cases reported in the literature. Accurate diagnosis and optimal management of this condition remains uncertain. We report a 51-year-old African gentleman, whom presents with abdominal pain and constipation. A computed tomography scan was performed and revealed a large cystic lesion in the right paracolic gutter. The differential diagnosis included appendiceal mucinous neoplasm, cystic tuberculosis and duplication cyst. A laparotomy was performed due to his symptoms and size of the cyst...
December 18, 2016: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/27980743/incidentally-discovered-low-grade-appendiceal-mucinous-neoplasm-a-precursor-to-pseudomyxoma-peritonei
#7
Vennila Padmanaban, William F Morano, Elizabeth Gleeson, Anshu Aggarwal, Beth L Mapow, David E Stein, Wilbur B Bowne
Appendiceal mucoceles (AMs) infrequently arise from an underlying malignancy. Treatment has progressed toward a less aggressive approach over time; they can be managed by appendectomy-only unless pathology reveals malignancy. The ultimate goal of management is to prevent AM rupture, avoiding the syndrome of pseudomyxoma peritonei.
December 2016: Clinical Case Reports
https://www.readbyqxmd.com/read/27957365/corrigendum-to-diagnosis-and-treatment-of-mucinous-appendiceal-neoplasm-presented-as-acute-appendicitis
#8
Ioannis Kehagias, Apollon Zygomalas, Georgios Markopoulos, Thanasis Papandreou, Pantelis Kraniotis
[This corrects the article DOI: 10.1155/2016/2161952.].
2016: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/27938333/pseudomyxoma-peritonei-of-a-mature-ovarian-teratoma-caused-by-mismatch-repair-deficiency-in-a-patient-with-lynch-syndrome-a-case-report
#9
Yoshimasa Gohda, Rei Noguchi, Tomoko Horie, Toru Igari, Harumi Nakamura, Yasunori Ohta, Kiyoshi Yamaguchi, Tsuneo Ikenoue, Seira Hatakeyama, Nozomi Yusa, Yoichi Furukawa, Hideaki Yano
BACKGROUND: Pseudomyxoma peritonei (PMP) is a rare disease with an estimated incidence of 1-2 cases per million individuals per year. PMP is characterized by the accumulation of abundant mucinous or gelatinous fluid derived from disseminated tumorous cells. Most of the tumorous cells are originated from rupture of appendiceal neoplasms, but some are from the metastasis of cancer of the colon, ovary, fallopian tube, urachus, colorectum, gallbladder, stomach, pancreas, lung and breast. Although frequent mutations in KRAS and/or GNAS genes have been reported, precise molecular mechanism underlying PMP remains to be elucidated...
December 9, 2016: BMC Medical Genetics
https://www.readbyqxmd.com/read/27913947/preclinical-evaluation-of-cathepsin-based-fluorescent-imaging-system-for-cytoreductive-surgery
#10
Carlos H F Chan, Lukas F Liesenfeld, Isabel Ferreiro-Neira, James C Cusack
BACKGROUND: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) is a treatment option for peritoneal surface malignancies. The ability to detect microscopic foci of peritoneal metastasis intraoperatively may ensure the completeness of cytoreduction. In this study, we evaluated the suitability of a hand-held cathepsin-based fluorescent imaging system for intraoperative detection of appendiceal and colorectal peritoneal metastasis. METHODS: Peritoneal tumors and normal peritoneal tissues were collected from patients with appendiceal and colorectal peritoneal metastasis...
December 2, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27913053/intestinal-metaplasia-of-appendiceal-endometriosis-is-not-uncommon-and-may-mimic-appendiceal-mucinous-neoplasm
#11
Monika Vyas, Serena Wong, Xuchen Zhang
Endometriosis of the appendix can be an incidental finding or a cause of appendicitis, intussusception, perforation or retention mucocele. Intestinal metaplasia of appendiceal endometriosis may occur, which can lead to a misdiagnosis of low-grade appendiceal mucinous neoplasm. On a retrospective search of the pathology database from 2001 to 2015, we identified 78 appendiceal endometriosis cases and intestinal metaplasia was present in 10/78 (13%) cases. In most of the cases (90%), the foci of intestinal metaplasia were mainly localized close to the mucosa...
January 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/27889016/is-it-necessary-to-perform-routine-appendectomy-for-mucinous-ovarian-neoplasms-a-retrospective-study-and-meta-analysis
#12
REVIEW
Aoshuang Cheng, Minghao Li, Margaux J Kanis, Ying Xu, Qing Zhang, Baoxia Cui, Jie Jiang, YouZhong Zhang, Xingsheng Yang, Beihua Kong
OBJECTIVES: To evaluate whether routine appendectomy is necessary in all patients with mucinous borderline ovarian tumor (mBOT) or mucinous ovarian cancer (MOC) who undergo gynecologic surgery. METHODS: The database of Qilu Hospital was searched for women who underwent appendectomy in a primary surgery for an ovarian tumor between June 2005 and June 2015 and whose final diagnosis was mBOT, MOC or primary appendiceal tumor. A retrospective review was performed, as well as a meta-analysis of the literature to further validate the findings...
January 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/27870702/synchronous-ovarian-and-appendiceal-mucinous-neoplasms-in-the-absence-of-pseudomyxoma-peritonei
#13
Xianyong Gui, Jorge Escobar, Cheng-Han Lee, Máire A Duggan, Martin Köbel
BACKGROUND: Synchronous ovarian/appendiceal mucinous neoplasms sometimes occur in the absence of clinical pseudomyxoma peritonei (PMP), which raises a question about whether the 2 tumors could be independent. METHODS: We identified 11 cases of synchronous ovarian/appendiceal mucinous neoplasms without PMP and subclassified them into groups 1 and 2 based on the presence or absence of microscopic peritoneal/ovarian surface mucin deposits. A 7-marker panel (CK7, CK20, CDX2, PAX8, MUC1, MUC2, and MUC5AC) immunohistochemistry was performed on both tumors...
February 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27843660/low-grade-appendiceal-mucinous-neoplasm-involving-the-endometrium-and-presenting-with-mucinous-vaginal-discharge
#14
Vera Vavinskaya, Joel M Baumgartner, Albert Ko, Cheryl C Saenz, Mark A Valasek
Primary appendiceal mucinous lesions are uncommon and represent a spectrum from nonneoplastic mucous retention cysts to invasive adenocarcinoma. Low-grade appendiceal mucinous neoplasms (LAMNs) represent an intermediate category on this spectrum and can be classified according to whether or not they are confined to the appendix. Although LAMNs are frequently confined to the appendix, they can also spread to the peritoneum and clinically progress as pseudomyxoma peritonei (i.e., mucinous ascites). Thus, the appropriate classification of appendiceal primary neoplasia is essential for prognosis and influences clinical management...
2016: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27822629/ultimate-clinical-outcomes-of-appendiceal-mucinous-neoplasm-of-uncertain-malignant-potential
#15
Rumi Shin, Young Jun Chai, Ji Won Park, Mee Soo Chang, Jeong Mo Bae, Min Jung Kim, Byung Kwan Park, Kyu Joo Park, Seung-Yong Jeong
BACKGROUND: The clinical outcome of appendiceal mucinous neoplasm (AMN) is not well understood. This study aimed to compare the long-term outcome for the uncertain malignant potential (UMP) subtype of AMNs with those of the mucinous adenoma (MA) and mucinous adenocarcinoma (MAC) subtypes. METHODS: In this study, AMNs were classified into three groups (MA, UMP, and MAC), and clinical characteristics, overall survival (OS), and progression-free survival (PFS) were compared among the three groups...
November 7, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27770344/when-and-when-not-to-perform-a-right-colon-resection-with-mucinous-appendiceal-neoplasms
#16
Paul H Sugarbaker
BACKGROUND: Mucinous appendiceal neoplasms (MAN) with peritoneal dissemination is treated as a standard of care using cytoreductive surgery and hyperthermic perioperative chemotherapy. The extent of the resection of peritoneal surfaces and visceral structures is generally well defined. Exception to this consensus regarding structures to be removed are the right colon and adjacent ileocolic lymph nodes. METHODS: From a prospectively maintained database, all patients with a histologic diagnosis of peritoneal mucinous carcinoma (PMCA) who underwent complete cytoreductive surgery were assessed for the presence versus absence of adenocarcinoma in lymph nodes within the appendiceal mesentery and/or in the lymph nodes of the ileocolic group...
March 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27718032/early-postoperative-intraperitoneal-chemotherapy-for-low-grade-appendiceal-mucinous-neoplasms-with-pseudomyxoma-peritonei-is-it-beneficial
#17
Yeqian Huang, Nayef A Alzahrani, Winston Liauw, Thamer B Traiki, David L Morris
BACKGROUND: There is little evidence for the use of early postoperative intraperitoneal chemotherapy (EPIC) in patients with low-grade appendiceal mucinous neoplasms (LAMNs) with pseudomyxoma peritonei (PMP). This study aims to assess the outcomes regarding the use of EPIC in a large cohort of patients with LAMNs with PMP uniformly treated by cytoreductive surgery (CRS) and perioperative intraperitoneal chemotherapy (PIC), all of whom received hyperthermic intraperitoneal chemotherapy (HIPEC), and most of whom also received EPIC...
January 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27712976/a-rare-low-grade-appendiceal-mucinous-neoplasm-pseudomyxoma-peritonei-with-ossification-a-case-report-with-morphoproteomic-analysis-of-bone-formation
#18
Byeong-Joo Noh, Youn Wha Kim, Yong-Koo Park
Heterotopic ossification occurring to low-grade appendiceal mucinous neoplasm (LAMN) (pseudomyxoma peritonei) is extremely rare. The pathogenetic mechanism of the tumor-related heterotopic bone formation remains as yet unconfirmed. Here, we describe a rare case of LAMN with ossification in a 72-year-old woman, and concentrate on the etiology of heterotopic ossification by the immunohistochemical evaluation of the novel markers such as BMP9, osteocalcin, and osteopontin. BMP9 is one of the most effective osteogenetic proteins...
November 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/27684884/synchronous-low-grade-appendiceal-mucinous-neoplasm-and-primary-peritoneal-low-grade-serous-carcinoma-a-first-description-of-these-2-neoplasms-presenting-together-as-suspected-peritoneal-carcinomatosis
#19
Miroslav Sekulic, Simona Pichler Sekulic, Saeid Movahedi-Lankarani
Low-grade appendiceal mucinous neoplasm is a neoplasm typically of appendiceal origin, which is characterized by diffuse peritoneal involvement by pools of mucin with mucinous epithelium lacking high-grade cytologic atypia, and clinically presents as suspected peritoneal carcinomatosis. A similar clinical presentation can sometimes be seen with disseminated low-grade serous carcinomas of the peritoneum, fallopian tubes, or ovaries; however, this neoplasm is histologically characterized by tubal-type epithelium and invasive or confluent growth...
September 28, 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/27660258/low-grade-appendiceal-mucinous-neoplasm-of-uncertain-malignant-potential-lamn-ump-prognostic-factors-and-implications-for-treatment-and-follow-up
#20
Keith Fournier, Safia Rafeeq, Melissa Taggart, Paul Kanaby, Jing Ning, Hsiang-Chun Chen, Michael Overman, Kanwal Raghav, Cathy Eng, Paul Mansfield, Richard Royal
BACKGROUND: Low-grade appendiceal mucinous neoplasm of uncertain malignant potential are poorly understood lesions characterized by extraluminal mucin or fibrosis with neoplastic cells confined to the appendiceal lumen. The purpose of this study is to investigate the clinical and pathologic parameters of these lesions to optimize our understanding and management of these tumors. METHODS: Subjects with these tumors were identified from the appendiceal tumor databases at the University of Texas MD Anderson Cancer Center...
January 2017: Annals of Surgical Oncology
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