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https://www.readbyqxmd.com/read/28725066/editorial-best-practices-in-surveillance-of-barrett-s-esophagus
#1
Sachin Wani, Srinivas Gaddam
Endoscopic surveillance in Barrett's esophagus (BE) has numerous limitations and thus provides several opportunities for improving the effectiveness of our current surveillance strategies. Several risk stratification and prediction tools have been investigated to identify patients at highest risk for progression to esophageal adenocarcinoma (EAC). Persistence of non-dysplastic BE (NDBE) has been proposed as an indicator of lower risk of progression to EAC. This editorial highlights the variable results and methodologies in studies evaluating persistence of NDBE as a risk stratification tool in the surveillance of BE patients and provides guidance for optimizing outcomes in BE patients enrolled in surveillance programs...
July 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28724656/dietary-flavonoid-intake-reduces-the-risk-of-head-and-neck-but-not-esophageal-or-gastric-cancer-in-us-men-and-women
#2
Lucy Sun, Amy F Subar, Claire Bosire, Sanford M Dawsey, Lisa L Kahle, Thea P Zimmerman, Christian C Abnet, Ruth Heller, Barry I Graubard, Michael B Cook, Jessica L Petrick
Background: Flavonoids are bioactive polyphenolic compounds found in fruits, vegetables, and beverages of plant origin. Previous studies have shown that flavonoid intake reduces the risk of certain cancers; however, few studies to date have examined associations of flavonoids with upper gastrointestinal cancers or used prospective cohorts.Objective: Our study examined the association between intake of flavonoids (anthocyanidins, flavan-3-ols, flavanones, flavones, flavonols, and isoflavones) and risk of head and neck, esophageal, and gastric cancers...
July 19, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28723668/a-rare-case-of-esophageal-metastasis-from-pancreatic-ductal-adenocarcinoma-a-case-report-and-literature-review
#3
Lauren M Rosati, Megan N Kummerlowe, Justin Poling, Amy Hacker-Prietz, Amol K Narang, Eun J Shin, Dung T Le, Elliot K Fishman, Ralph H Hruban, Stephen C Yang, Matthew J Weiss, Joseph M Herman
PURPOSE: We report a very unique case of an esophageal metastasis from a pancreatic ductal adenocarcinoma (PDAC) primary. METHODS: After obtaining consent from the patient, all relevant records of the case were obtained and retrospectively reviewed. RESULTS: At presentation, the patient was diagnosed with synchronous pancreatic and esophageal cancer. He received six months of neoadjuvant therapy including FOLFIRINOX (5-fluorouracil, leucovorin, irinotecan, and oxaliplatin) and stereotactic body radiation therapy (SBRT) to the pancreatic tumor followed by a combined pancreaticoduodenectomy and Ivor Lewis esophagectomy...
June 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28722096/-neoadjuvant-chemoradiotherapy-combined-with-operation-vs-operation-alone-for-resectable-esophageal-cancer-meta-analysis-on-randomized-controlled-trials
#4
Xiaofeng Duan, Zhentao Yu
OBJECTIVE: To compare the treatment outcomes of neoadjuvant chemoradiotherapy (NCRT) combined with operation and operation alone for esophageal cancer. METHODS: Randomized controlled trials(RCTs), comparing the treatment outcomes of NCRT combined with operation to operation alone for esophageal cancer, published from January 1990 to December 2015 were searched from PubMed, Web of Science, and other English-language databases. STATA 10.0 software was used to analyze short-term efficacy (R0 resection rate, positive lymph node ratio, postoperative complications and mortality) and long-term outcomes (overall survival rate and local recurrence rate)...
July 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28716721/the-evolving-genomic-landscape-of-barrett-s-esophagus-and-esophageal-adenocarcinoma
#5
REVIEW
Gianmarco Contino, Thomas L Vaughan, David Whiteman, Rebecca Fitzgerald
We have recently gained unprecedented insight into genetic factors that determine risk for Barrett's esophagus (BE) and progression to esophageal adenocarcinoma (EA). Next-generation sequencing technologies have allowed us to identify somatic mutations that initiate BE and track genetic changes during development of tumors and invasive cancer. These technologies led to identification of mechanisms of tumorigenesis that challenge the current multi-step model of progression to EA. Newer, cost-effective technologies create opportunities to rapidly translate the analysis of DNA into tools that can identify patients with BE at high risk for cancer, detect dysplastic lesions at earlier stages, and uncover mechanisms of carcinogenesis...
July 14, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28710822/prevalence-and-significance-of-hmga2-expression-in-esophageal-adenocarcinoma
#6
Jeffrey K Mito, Agoston T Agoston, Paola Dal Cin, Amitabh Srivastava
AIMS: Esophageal adenocarcinoma (EAC) tumorigenesis has been primarily linked to loss-of-function mutations in tumor suppressor genes. Knowledge of specific oncogenes that drive tumor progression, and their relationship to outcomes, is limited. High Mobility Group AT-Hook 2 (HMGA2) has been reported to be amplified in a subset of EACs, but the clinicopathologic and prognostic implications of HMGA2 expression in EAC is unknown. METHODS AND RESULTS: We performed HMGA2 immunohistochemistry and fluorescence in-situ hybridization (FISH) in EAC to determine its clinicopathologic and prognostic significance...
July 15, 2017: Histopathology
https://www.readbyqxmd.com/read/28708307/evaluation-of-short-term-effectiveness-of-eight-targeted-agents-combined-with-chemotherapy-for-treating-esophageal-gastric-junction-adenocarcinoma-a-network-meta-analysis
#7
Yong-Ming He, Chen Yu, Wei-Bing Li, Zhi-Peng Li, Nan Xu
This study aimed to evaluate the short-term effectiveness of eight targeted agents (ramucirumab, bevacizumab, rilotumumab, panitumumab, cetuximab, trebananib, trastuzumab, matuzumab) plus chemotherapy in esophageal-gastric junction adenocarcinoma (EGJA) by a network meta-analysis (NMA). PubMed, Embase, and Cochrane Library databases were systematically retrieved for randomized clinical trials (RCTs) concerning targeted agents plus chemotherapy in the treatment of EGJA. This NMA combined both direct and indirect evidence to evaluate odds ratio (OR) and to draw the surface under the cumulative ranking curve (SUCRA)...
July 14, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28702133/cytotoxic-effect-of-rosemary-extract-on-gastric-adenocarcinoma-ags-and-esophageal-squamous-cell-carcinoma-kyse30-cell-lines
#8
Neamat Karimi, Jalil Rashedi, Behroz Mahdavi Poor, Sepideh Arabi, Maryam Ghorbani, Nahideh Tahmasebpour, Mohammad Asgharzadeh
AIM: The present study was conducted to survey the potential cytotoxic influence of freeze-dried aqueous extract of its fruits on gastrointestinal cell lines, namely AGS (human gastric carcinoma) and KYSE30 (human esophageal squamous cell carcinoma. BACKGROUND: Rosemary (Rosmarinus officinalis) is a wild medicinal plant shown to have anticancer activity. Carnosic and rosmarinic acids are compounds, obtained from it through several extraction methods. METHODS: The aqueous extract of the fruits of R...
2017: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/28697153/mucin-expression-in-the-esophageal-malignant-and-premalignant-states-a-systematic-review-and-meta-analysis
#9
Yaron Niv, Samuel B Ho, Ronnie Fass, Theodore Rokkas
BACKGROUND: Mucins are heavily glycosylated glycoproteins, synthesized by mucosal surfaces and have an important role in healthy state and malignant diseases. Change in mucins synthesis or secretion may be primary event or secondary to inflammation or carcinogenesis. AIM: The aim of this study is to assess the current knowledge about mucin expression in esophageal lesions, and to establish a role for different mucin expressions as prognostic markers. METHOD: English Medical literature searches were conducted for "mucin" and "esophagus...
July 10, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28687830/effect-of-the-addition-of-cetuximab-to-paclitaxel-cisplatin-and-radiation-therapy-for-patients-with-esophageal-cancer-the-nrg-oncology-rtog-0436-phase-3-randomized-clinical-trial
#10
Mohan Suntharalingam, Kathryn Winter, David Ilson, Adam P Dicker, Lisa Kachnic, André Konski, A Bapsi Chakravarthy, Christopher J Anker, Harish Thakrar, Naomi Horiba, Ajay Dubey, Joel S Greenberger, Adam Raben, Jeffrey Giguere, Kevin Roof, Gregory Videtic, Jondavid Pollock, Howard Safran, Christopher H Crane
Importance: The role of epidermal growth factor receptor (EGFR) inhibition in chemoradation strategies in the nonoperative treatment of patients with esophageal cancer remains uncertain. Objective: To evaluate the benefit of cetuximab added to concurrent chemoradiation therapy for patients undergoing nonoperative treatment of esophageal carcinoma. Design, Setting, and Participants: A National Cancer Institute (NCI) sponsored, multicenter, phase 3, randomized clinical trial open to patients with biopsy-proven carcinoma of the esophagus...
July 6, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28687434/prevalence-of-barrett-s-esophagus-an-observational-study-from-a-gastroenterology-clinic
#11
J L Herrera Elizondo, R Monreal Robles, D García Compean, E I González Moreno, O D Borjas Almaguer, H J Maldonado Garza, J A González González
INTRODUCTION AND AIMS: Barrett's esophagus is a condition that predisposes to esophageal adenocarcinoma. Our aim was to establish the prevalence of Barrett's esophagus at our center, as well as determine its associated factors. MATERIALS AND METHODS: We retrospectively assessed the endoscopic reports of 500 outpatients seen at our Gastroenterology Service from November 2014 to April 2016. We determined the prevalence of Barrett's esophagus and analyzed the demographic, clinical, and endoscopic findings associated with that pathology...
July 4, 2017: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/28687396/the-impact-of-histology-on-recurrence-patterns-in-esophageal-cancer-treated-with-definitive-chemoradiotherapy
#12
Mian Xi, Cai Xu, Zhongxing Liao, Wayne L Hofstetter, Mariela Blum Murphy, Dipen M Maru, Manoop S Bhutani, Jeffrey H Lee, Brian Weston, Ritsuko Komaki, Steven H Lin
BACKGROUND: To assess the impact of histology on recurrence patterns and survival outcomes in patients with esophageal cancer (EC) treated with definitive chemoradiotherapy (CRT). METHODS: We analyzed 590 consecutive EC patients who received definitive CRT from 1998 to 2014, including 182 patients (30.8%) with squamous cell carcinoma (SCC) and 408 (69.2%) with adenocarcinoma. Recurrence pattern and timing, survival, and potential prognostic factors were compared...
July 4, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28685276/post-trimodality-expression-levels-of-metadherin-mtdh-as-a-prognostic-biomarker-for-esophageal-adenocarcinoma-patients
#13
Dilsa Mizrak Kaya, Xiaochuan Dong, Graciela M Nogueras-González, Yan Xu, Jeannelyn S Estrella, Kazuto Harada, Anthony Lopez, Fatemeh G Amlashi, Wayne L Hofstetter, Dipen M Maru, Quynh-Nhu Nguyen, Jeffrey H Lee, Brian Weston, Manoop S Bhutani, Jeremy J Erasmus, Irene Thomas, Jane E Rogers, Shumei Song, Jaffer A Ajani
Resectable esophageal adenocarcinoma (EAC) patients often receive chemoradiation followed by surgery. However, most patients experience recurrences. Overexpression of MTDH, an oncoprotein with multiple functions, has been found to be associated with poor prognosis in breast cancer, glioblastoma, melanoma and various gastrointestinal malignancies, but not in EAC. We sought to establish its role in resistant EAC (post-treatment residual EAC). MTDH was assessed by immunohistochemistry in resected EAC, and results were correlated with clinical outcomes...
August 2017: Medical Oncology
https://www.readbyqxmd.com/read/28685091/asbestos-related-lung-cancers-a-retrospective-clinical-and-pathological-study
#14
Marie Uguen, Jean-Dominique Dewitte, Pascale Marcorelles, Brice Loddé, Richard Pougnet, Philippe Saliou, Marc De Braekeleer, Arnaud Uguen
Exposure to asbestos results in serious risks of developing mesothelioma and lung cancer. The link between asbestos exposure and lung carcinoma is well established. Nevertheless, precise histopathological data are poorly considered when investigating the asbestos-cancer link in a compensatory approach. In the present study, we aim to describe the features of individuals with compensated lung cancer who were referred to an occupational disease center, regarding occupational exposure to asbestos, smoking history and pathological data...
July 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28683988/signet-rings-around-the-world
#15
EDITORIAL
Philip Carrott
Esophageal and gastric adenocarcinoma of signet ring subtype is aggressive and portends a poor prognosis. This subtype of an already aggressive cancer metastasizes widely and can progress quickly. Hart and colleagues outline an unusual and specific metastasis following resection of signet ring esophageal adenocarcinoma. More frequent surveillance for resected patients may help identify metastases early.
April 2017: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28683987/node-negative-esophageal-cancer-with-short-interval-isolated-metastasis-to-the-gallbladder-a-case-report
#16
Christopher M Hart, Kelly R Haisley, Christian Lanciault, James P Dolan
A 55 year old male smoker presented with clinical T3N0 esophageal adenocarcinoma of the GE junction. He completed neoadjuvant chemoradiotherapy with carboplatin/paclitaxel and 5040cGy of radiation. He had limited clinical response on restaging but no evidence of metastatic disease and completed a minimally invasive three field esophagectomy. This was complicated by a chyle leak requiring thoracic duct embolization from which he recovered well. Surgical pathology showed no apparent nodal disease or metastases but a poorly differentiated primary tumor with signet-cell features...
April 2017: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28683070/physical-activity-domains-and-risk-of-gastric-adenocarcinoma-in-the-mcc-spain-case-control-study
#17
José M Huerta, María Dolores Chirlaque, Antonio J Molina, Pilar Amiano, Vicente Martín, Tania Fernández-Villa, Beatriz Pérez-Gómez, Víctor Moreno, Rosana Burgui, Inés Gómez-Acebo, Manuel Ramos-Lora, Guillermo Fernández-Tardón, Rosana Peiró, Rocío Olmedo-Requena, Marina Pollán, Manolis Kogevinas, Gemma Castaño-Vinyals, Nuria Aragonés
BACKGROUND: Evidence for a protective role of physical activity against development of stomach cancer is yet inconclusive. We studied the association of domain-specific physical activity and the risk of gastric adenocarcinoma (GAC), by site and histology, in the MCC-Spain case-control study. METHODS: 428 histologically confirmed GAC cases (67% men) including the gastro-esophageal region and 3225 controls were included. Cases were recruited in hospitals from 10 different Spanish regions, whereas population controls were randomly selected within the respective hospitals' catchment areas...
2017: PloS One
https://www.readbyqxmd.com/read/28670387/down-regulation-of-long-non-coding-rna-afap1-as1-inhibits-tumor-cell-growth-and-invasion-in-lung-adenocarcinoma
#18
Yi Zhuang, Hanyi Jiang, Hui Li, Jinhong Dai, Yin Liu, Yan Li, Liyun Miao, Hourong Cai, Yonglong Xiao, Hongping Xia, Yongsheng Wang, Mingke Shi
An increasing number of deregulated long non-coding RNAs (lncRNA) have been implicated in cancer in humans, suggesting that lncRNAs may be involved in tumorigenesis or tumor progression. In previous investigations, lncRNA, AFAP1-AS1 has been found to be associated with several cancers, including nasopharyngeal carcinoma, lung cancer and esophageal adenocarcinoma. However, the function of AFAP1-AS1 in lung cancer has not been reported. In our present study, we found that AFAP1-AS1 was overexpressed in lung adenocarcinoma and associated with survival time...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28666927/prognostic-significance-of-igg4-plasma-cell-infiltrates-following-neoadjuvant-chemoradiation-therapy-for-esophageal-adenocarcinoma
#19
Evgeny Yakirevich, Shaolei Lu, Danisha Allen, Shamlal Mangray, Jacqueline R Fanion, Kara A Lombardo, Howard Safran, Murray B Resnick
Lymphoplasmacytic infiltrates in esophageal adenocarcinoma (EAC) tissue following chemoradiotherapy (CRT) reflect alterations in the tumor immunoenvironment. The presence and role of plasma cells in this process are poorly understood. Our aim was to characterize the IgG4+ plasma cell population in EAC following CRT. Seventy-one esophagectomy specimens post CRT were compared to a surgery only group of 31 EACs. The distribution, density, and ratio of IgG4+ and IgG+ plasma cells were evaluated by immunohistochemistry and correlated with clinicopathologic features, treatment response, and survival...
June 27, 2017: Human Pathology
https://www.readbyqxmd.com/read/28666313/an-update-of-the-wcrf-aicr-systematic-literature-review-and-meta-analysis-on-dietary-and-anthropometric-factors-and-esophageal-cancer-risk
#20
S Vingeliene, D S M Chan, A R Vieira, E Polemiti, C Stevens, L Abar, D Navarro Rosenblatt, D C Greenwood, T Norat
Background: In the 2007 World Cancer Research Fund/American Institute for Cancer Research Second Expert Report, the expert panel judged that there was strong evidence that alcoholic drinks and body fatness increased esophageal cancer risk, whereas fruits and vegetables probably decreased its risk. The judgments were mainly based on case-control studies. As part of the Continuous Update Project (CUP), we updated the scientific evidence accumulated from cohort studies in this topic. Methods: We updated the CUP database up to 10 January, 2017 by searching in PubMed and conducted dose-response meta-analyses to estimate summary relative risks (RRs) and 95% confidence intervals (CIs) using random effects model...
June 29, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
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