keyword
MENU ▼
Read by QxMD icon Read
search

Esophageal adenocarcinoma

keyword
https://www.readbyqxmd.com/read/29454095/an-esophageal-adenocarcinoma-susceptibility-locus-at-9q22-also-confers-risk-to-esophageal-squamous-cell-carcinoma-by-regulating-the-function-of-barx1
#1
Caiwang Yan, Yong Ji, Tongtong Huang, Fei Yu, Yong Gao, Yayun Gu, Qi Qi, Jiangbo Du, Juncheng Dai, Hongxia Ma, Guangfu Jin
Genome wide association studies (GWAS) have identified a series of genetic variants associated with the risk of esophageal adenocarcinoma (EAC)/Barrett's esophagus (BE), which was different from those loci for esophageal squamous cell carcinoma (ESCC). It is important to evaluate whether these susceptibility loci for EAC/BE are also implicated in ESCC development. In the current study, we analyzed genetic variants at 3p13, 9q22, 16q24 and 19p13 in a case-control study including 2139 ESCC patients and 2463 cancer-free controls in a Chinese population, and further characterized the biological relevance of genetic variants by functional assays...
February 14, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29437006/enteral-administration-of-tkis-report-of-a-response-to-ceritinib-in-an-alk-positive-nsclc-patient-and-literature-review
#2
Francesco Facchinetti, Paola Bordi, Paola Bini, Livia Bidin, Roberta Camisa, Marcello Tiseo
INTRODUCTION: Several reports attest the feasibility and the favorable outcomes of kinase inhibitors administration through feeding tubes or percutaneous endoscopic gastrostomies (PEG), mainly in non-small cell lung cancer (NSCLC) patients exposed to first-generation compounds. Here we present the case of an ALK-positive NSCLC patient who achieved cerebral and extra-cranial disease response with ceritinib (a novel ALK inhibitor) administered through a nasogastric tube (NGT). We moreover provide a review gathering clinical successes obtained with targeted agents intake through NGT or PEG...
February 12, 2018: Current Drug Targets
https://www.readbyqxmd.com/read/29436979/thoracoscopic-total-esophagogastrectomy-with-supercharged-colon-interposition-for-the-treatment-of-esophageal-adenocarcinoma-in-situs-inversus
#3
Alexandros Charalabopoulos, Ali Kordzadeh, Elias Sdralis, Bruno Lorenzi, Fateh Ahmad
BACKGROUND: Esophagectomy in situs inversus is challenging. With long-segment supercharged reconstruction, it becomes more perplexing and multidisciplinary surgical skills are needed. Challenges met and the surgical technique used is presented in this case report. METHODS: The case of a 49-year old patient with situs inversus abdominus and a locally advanced distal esophageal adenocarcinoma extending to the stomach is presented. RESULTS: Following neoadjuvant chemotherapy and due to inability to use the stomach as a conduit, a thoracoscopic total esophagogastrectomy with long-segment reconstruction was performed...
February 13, 2018: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/29435301/traditional-and-cumulative-meta-analysis-chemoradiotherapy-followed-by-surgery-versus-surgery-alone-for-resectable-esophageal-carcinoma
#4
Haiming Feng, Ye Zhao, Tao Jing, Jianxing Ma, Yinglu Zhao, Jianhua Zhang, Cheng Wang, Bin Li
The role of neoadjuvant chemoradiotherapy followed by surgery (CRTS) compared with surgery alone (SA) for resectable esophageal carcinoma has been established by several randomized controlled trials (RCTs). The present study aimed to investigate the difference in survival between the two treatments by a review of meta-analyses. Related research indicators were extracted from RCTs investigating CRTS or SA for resectable esophageal carcinoma by searching electronic databases for eligible articles. Outcomes were synthesized by adopting a fixed- or random-effects model with 95% confidence interval (CI)...
February 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29435289/outcomes-of-abdominal-esophageal-cancer-patients-who-were-treated-with-esophagectomy
#5
Hiroyuki Kitagawa, Tsutomu Namikawa, Jun Iwabu, Kazune Fujisawa, Michiya Kobayashi, Kazuhiro Hanazaki
The aim of the present study was to elucidate the characteristics and outcomes of abdominal esophageal cancer patients who were treated with esophagectomy. The records of 210 esophagectomy patients were retrospectively reviewed and the differences in postoperative outcomes and disease-specific survival between squamous cell carcinoma and adenocarcinoma were evaluated. Of the 20 abdominal esophageal cancer patients, 11 had squamous cell carcinoma, 8 had adenocarcinoma and 1 had adenosquamous cell carcinoma. The body mass index and serum albumin levels were significantly lower in the squamous cell carcinoma patients compared with those in the adenocarcinoma patients, and abdominal lymph node metastasis was significantly more frequent in the adenocarcinoma patients...
February 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29432922/use-of-appropriate-surveillance-for-patients-with-non-dysplastic-barrett-s-esophagus
#6
Anna Tavakkoli, Henry D Appelman, David G Beer, Chaitra Madiyal, Maryam Khodadost, Kimberly Nofz, Val Metko, Grace Elta, Thomas Wang, Joel H Rubenstein
BACKGROUND & AIMS: Barrett's Esophagus (BE) is a precursor to esophageal adenocarcinoma (EAC). Guidelines recommend that patients with nondysplastic BE (NDBE) undergo surveillance endoscopy every 3-5 years. We aimed to identify factors associated with surveillance endoscopy of patients with NDBE and identify trends in appropriate surveillance endoscopy of NDBE at a large tertiary care center. METHODS: We performed a retrospective analysis of data from a Barrett's Esophagus Registry, identifying patients with NDBE who underwent endoscopy in 2002 or later...
February 9, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29430220/esophageal-metastatic-adenocarcinoma-diagnosed-with-endoscopic-ultrasound
#7
Guo Xiang Jonathan Teh, Damien Tan, Jen Lock Khor, Wei Keat Wan, Yu Tien Wang
Metastasis to the esophagus from a distant primary cancer is a rare manifestation in a patient with a history of oncological disease presenting with obstructive upper gastrointestinal symptoms. Computed tomography of the thorax or esophagogastroduodenoscopy can be non-diagnostic as the disease tends to be submucosal. In such a situation, endoscopic ultrasound (EUS) with fine needle aspiration (FNA) can be directed to characterize and sample the submucosal esophageal lesion. We present a case series of metastatic esophageal strictures diagnosed with EUS and FNA...
September 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/29429625/continuing-the-search-for-mutational-drivers-in-esophageal-adenocarcinoma
#8
EDITORIAL
Pamela Samson
No abstract text is available yet for this article.
December 26, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29426452/choroidal-metastasis-arising-from-esophageal-adenocarcinoma
#9
Maxwell G Su, Brian P Schallenberg, Michael A Magee
No abstract text is available yet for this article.
February 2018: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/29423892/total-vs-proximal-gastrectomy-for-adenocarcinoma-of-the-upper-third-of-the-stomach-a-propensity-score-matched-analysis-of-a-multicenter-western-experience-on-behalf-of-the-italian-research-group-for-gastric-cancer-gircg
#10
Fausto Rosa, Giuseppe Quero, Claudio Fiorillo, Massimiliano Bissolati, Chiara Cipollari, Stefano Rausei, Damiano Chiari, Laura Ruspi, Giovanni de Manzoni, Guido Costamagna, Giovanni Battista Doglietto, Sergio Alfieri
BACKGROUND: The aim of this study is to compare surgical outcomes including postoperative complications and prognosis between total gastrectomy (TG) and proximal gastrectomy (PG) for proximal gastric cancer (GC). Propensity-score-matching analysis was performed to overcome patient selection bias between the two surgical techniques. METHODS: Among 457 patients who were diagnosed with GC between January 1990 and December 2010 from four Italian institutions, 91 underwent PG and 366 underwent TG...
February 8, 2018: Gastric Cancer
https://www.readbyqxmd.com/read/29421911/intrathoracic-leak-after-an-ivor-lewis-procedure-for-an-esophageal-neoplasm-treated-with-a-stent
#11
Natalia Afonso Luis, Maria Asunsión Acosta Mérida, Joaquín Marchena Gómez
A 75-year-old male who underwent an Ivor Lewis esophagectomy due to a distal adenocarcinoma had a leak at the gastroplasty on the 5th day after surgery, which required two surgeries and a primary suture. He was transferred to our hospital due to a poor outcome and endoscopy revealed a 2.5cm gap perianastomotically on the gastroplasty wall, for which a stent was placed. Due to hemodynamic impairment, a thoracotomy procedure was performed, which revealed stent protrusion into the cavity. The patient underwent an esophagogastric anastomosis resection, cervical esophagostomy and gastrostomy...
February 9, 2018: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29417867/bioinformatic-analyses-of-microrna-targeted-genes-and-microarray-identified-genes-correlated-with-barrett-s-esophagus
#12
Jing Lv, Jijun Liu, Lei Guo, Jun Zhang, Yan Cheng, Chu Chen, Heping Zhao, Jihan Wang
Barrett's esophagus (BE) is defined as a metaplasia condition in the distal esophagus, in which the native squamous epithelium lining is replaced by a columnar epithelium with or without intestinal metaplasia. It is commonly accepted that BE is a precancerous lesion for esophageal adenocarcinoma. The aim of this study was to investigate the aberrant microRNAs (miRNAs) and differentially expressed genes (DEGs) associated with BE based on online microarray datasets. One miRNA and five gene expression profiling datasets were retrieved from the Gene Expression Omnibus Database...
February 8, 2018: Cell Cycle
https://www.readbyqxmd.com/read/29416661/gli-is-activated-and-promotes-epithelial-mesenchymal-transition-in-human-esophageal-adenocarcinoma
#13
Lei Wang, Joy Q Jin, Yong Zhou, Ziqiang Tian, David M Jablons, Biao He
Esophageal adenocarcinoma (EAC) accounts for the most esophageal cancer cases in the US, and is notoriously aggressive. This study examines the role of Sonic Hedgehog (SHh)/Gli signaling in the regulation of epithelial-mesenchymal transition (EMT), a process tied to invasion and metastasis, in EAC. Gli/EMT protein expression levels were examined by western blot in paired EAC patient tissues (n = 24) and cell lines (OE19, OE33). Functional analyses were performed (siRNA, treatment with Gli-inhibitor, AKT-inhibitor, and N-Shh recombinant proteins) to investigate SHh/Gli signaling and EMT, cell cycle, and prognostic markers in EAC cell lines...
January 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29403085/tumor-budding-as-a-standardized-parameter-in-gastrointestinal-carcinomas-more-than-just-the-colon
#14
REVIEW
Kyra B Berg, David F Schaeffer
Tumor budding, defined as single cells or clusters of less than five cells, is thought to be a histomorphologic marker of an aggressive tumor behavior mimicking the embryologic epithelial-mesenchymal transition, and has been well established in the past two decades as a poor prognostic factor in colorectal carcinoma. Slow uptake in routine reporting of this important pathologic prognostic feature was in part due to differing methods of assessment of budding reported in the literature, but has recently been clarified at a consensus conference on tumor budding in colorectal carcinoma...
February 6, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29394740/-a-case-of-esophago-gastric-junctional-carcinoma-with-intramural-invasion-and-cervical-lymph-node-metastasis
#15
Hidekazu Hiramoto, Hirotaka Konishi, Atsushi Shiozaki, Hitoshi Fujiwara, Tomohiro Arita, Toshiyuki Kosuga, Ryo Morimura, Yasutoshi Murayama, Yoshiaki Kuriu, Hisashi Ikoma, Masayoshi Nakanishi, Kazuma Okamoto, Eigo Otsuji
The patient was a 66-year-old man who was diagnosed with a type 3 lesion in the esophago-gastric junction and a type 1 lesion in the upper esophagus. Both the lesions were diagnosed as adenocarcinoma. Chest and abdominal computed tomography examinations pointed out No. 106recL lymph node metastasis. He was diagnosed with Stage III esophago-gastric cancer( T2N3M0)and treated by a laparoscopic subtotal esophagectomy with 2-field lymph node dissection. The histological diagnosis was type 3 adenocarcinoma in the esophago-gastric junction with intramural metastasis and massive lymph node metastasis(No...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394728/-long-term-survivor-of-a-barrett-s-esophageal-adenocarcinoma-who-underwent-three-times-surgical-resection-and-multidisciplinarytherapyfor-lymph-node-recurrences-report-of-a-case
#16
Ayumi Takaoka, Shigeo Haruki, Hiroko Matsunaga, Masaki Tashiro, Kaida Arita, Shinsuke Usui, Koji Ito, Akiyo Matsumoto, Noriaki Takiguchi
We report a case of a 42-year-old man who underwent 3 times surgical resection for lymph nodes recurrence and multidisciplinary therapy for Stage IV b Barrett's esophageal adenocarcinoma, and was well 6 years and 3 months after the first resection. The prognosis of the recurrence cases after radical recection of the esophageal cancer is extremely poor. Long-term prognosis may be obtained in few patients, but the cases are squamous cell carcinoma in most of the reported cases. The number of Barrett's esophageal adenocarcinoma patients is increasing, but it is not many...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394665/-subtotal-esophagectomy-for-mediastinal-lymph-node-oligo-recurrence-of-alk-positive-lung-adenocarcinoma-a-case-report
#17
Satoshi Tetsumoto, Kaoru Okada, Hideki Nagata, Shigenori Toyota, Satoshi Tanaka, Toshie Niki, Naotoshi Tsuruta, Naozumi Higaki, Takashi Niju, Yoshio Oka, Riichiro Nezu, Toshiyuki Ikeda
The patient was a 54-year-old woman with anaplastic lymphoma kinase-positive stage III B lung cancer. She received 4 courses of carboplatin(CBDCA)plus paclitaxel(PTX)plus bevacizumab(Bev)chemotherapy and crizotinib. Chemotherapy reduced the size of the primary site and mediastinal lymphadenopathy; however, the right supraclavicular and subcarinal lymph nodes were enlarged again during crizotinib treatment. Because it was an oligo-recurrence, we performed radiotherapy for these lymph nodes and changed systemic chemotherapy to alectinib...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29393168/endoscopic-submucosal-dissection-for-adenocarcinomas-of-the-esophagogastric-junction
#18
Yasuaki Nagami, Masaki Ominami, Koji Otani, Shuhei Hosomi, Fumio Tanaka, Koichi Taira, Noriko Kamata, Hirokazu Yamagami, Tetsuya Tanigawa, Masatsugu Shiba, Toshio Watanabe, Yasuhiro Fujiwara
BACKGROUND: Adenocarcinoma of the esophagogastric junction (EGJ) is uncommon in Eastern countries, including Japan, but it is believed that the incidence of EGJ adenocarcinoma will increase in Asia in the future due to the decreasing incidence of Helicobacter pylori infection. Endoscopic submucosal dissection (ESD) is a minimally invasive and curative treatment that allows precise pathological assessment. SUMMARY: Magnifying endoscopy with narrow-band imaging may be useful for differential diagnoses and for delineating the cancer margin of EGJ adenocarcinoma, but subsquamous carcinoma extension, which is the invasion of EGJ adenocarcinoma beneath the normal esophageal squamous epithelium, makes it difficult to detect cancer margins of the oral side in ESD for EGJ adenocarcinoma...
February 1, 2018: Digestion
https://www.readbyqxmd.com/read/29392342/-surgical-strategy-for-early-stage-carcinoma-of-the-esophagus
#19
REVIEW
N Niclauss, M Chevallay, J L Frossard, S P Mönig
Early stage carcinomas of the esophagus are histologically differentiated into adenocarcinomas and squamous cell carcinomas and subdivided into mucosal (m1-3) and submucosal (sm1-3) carcinomas depending on the infiltration depth. While the prevalence of lymph node metastases in mucosal carcinomas is very low, the probability of lymph node metastases increases from submucosal infiltration with increasing depth. According to the current German S3 guidelines endoscopic resection is the recommended treatment strategy for mucosal adenocarcinoma without histological risk factors (lymphatic invasion [L1], venous invasion [V1], poorly differentiated [>G2], microscopic residual disease [R1] at the deep resection margin)...
February 1, 2018: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/29383151/high-protein-and-mrna-expression-levels-of-tubb3-class-iii-%C3%A3-tubulin-are-associated-with-aggressive-tumor-features-in-esophageal-adenocarcinomas
#20
Heike Loeser, Simon Schallenberg, Moritz von Winterfeld, Lars Tharun, Hakan Alakus, Arnulf Hölscher, Elfriede Bollschweiler, Reinhard Buettner, Thomas Zander, Alexander Quaas
Background: Esophageal adenocarcinomas show an increasing incidence in the Western world and their overall survival remains low. Microtubules are multifunctional cytoskeletal proteins involved in crucial cellular roles, including maintenance of cell shape, intracellular transport, meiosis, and mitosis. Microtubulus-TUBB3 was found overexpressed in several carcinomas suggesting a significant role in cancer development. High levels of TUBB3 expression were also described to be associated with poor clinical outcome in various cancers...
December 29, 2017: Oncotarget
keyword
keyword
17576
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"