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Esophageal adenocarcinoma

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https://www.readbyqxmd.com/read/29680981/future-of-diagnosing-neoplasia-in-barrett-s-esophagus-volumetric-laser-endomicroscopy
#1
REVIEW
Muhammad Aziz, Rawish Fatima
Esophageal adenocarcinoma (EAC) is one of the deadliest carcinoma faced by gastroenterologists. Any insult to esophagus that causes replacement of normal squamous epithelium with columnar intestinal epithelium is labelled as the initiating event of the metaplasia-neoplasia sequence. Barrett's esophagus is the precursor to EAC. Currently, endoscopically obtained biopsies are used to detect neoplastic changes in patients with Barrett's esophagus (BE); however, it is not cost effective and hence a better screening modality is needed...
April 21, 2018: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/29676351/evaluation-of-p53-protein-expression-in-barrett-esophagus
#2
Mahathi Krothapalli, Jyoti Ramnath Kini, Hema Kini, Kausalya Kumari Sahu, Suresh Shenoy, Sandeep Gopal Krishna, B V Tantry
Background: Loss of heterozygosity of p53 along with aneuploidy is deemed to be the early molecular steps in Barrett metaplasia-dysplasia-adenocarcinoma sequence. Objective biomarkers need to be used along with microscopy for risk stratification to predict the progression of Barrett esophagus (BE) to carcinoma. Aim: This study aims to study p53 protein expression in dysplasia and correlate the same with morphology in BE. Materials and Methods: A time-bound study was conducted from January 2011 to June 2015...
April 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29675664/how-should-we-report-endoscopic-results-in-patient-s-with-barrett-s-esophagus
#3
REVIEW
Venkata Subhash Gorrepati, Prateek Sharma
Barrett's esophagus is the only known pre-cancerous lesion for esophageal adenocarcinoma and is diagnosed by high-definition white light endoscopy demonstrating a columnar-lined esophagus along with biopsy evidence of intestinal metaplasia. With accurate performance and reporting of the endoscopic procedure, an evidence-based management strategy can be developed for treatment of Barrett's dysplasia. However, cross-sectional data demonstrate that there is still inconsistency among gastroenterologists in performance and reporting of endoscopic findings in patients with Barrett's esophagus...
April 19, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29675663/origins-of-metaplasia-in-barrett-s-esophagus-is-this-an-esophageal-stem-or-progenitor-cell-disease
#4
REVIEW
Wei Zhang, David H Wang
The incidence of esophageal adenocarcinoma has been increasing in Western countries over the past several decades. Though Barrett's esophagus, in which the normal esophageal squamous epithelium is replaced with metaplastic intestinalized columnar cells due to chronic damage from gastroesophageal reflux, is accepted as the requisite precursor lesion for esophageal adenocarcinoma, the Barrett's esophagus cell of origin and the molecular mechanism underlying esophageal epithelial metaplasia remain controversial...
April 19, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29672407/survival-implications-of-increased-utilization-of-local-excision-for-ct1n0-esophageal-cancer
#5
Emily C Sturm, Whitney E Zahnd, John D Mellinger, Sabha Ganai
OBJECTIVE: We hypothesized that patients with cT1N0 esophageal cancer undergoing local excision would have lower survival compared with esophagectomy due to potential discordant staging. BACKGROUND: Local excision has become an attractive alternative for management of early esophageal cancer, avoiding the morbidity of esophagectomy. It is uncertain if occult nodal metastasis impacts survival. METHODS: An observational study was conducted using the National Cancer Database (1998-2012) for patients with clinical T1N0 esophageal cancer who underwent local excision (n = 1625) or esophagectomy (n = 3255)...
April 18, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29671160/cardiac-metaplasia-follow-treat-or-ignore
#6
REVIEW
Stuart J Spechler
Over the past two decades, evidence has accumulated to challenge the traditional view that cardiac mucosa, which is comprised exclusively of mucus glands, is the normal lining of the most proximal portion of the stomach (the gastric cardia). There is now considerable evidence to suggest that cardiac mucosa develops as a GERD-induced, squamous-to-columnar esophageal metaplasia in some, if not all, cases. Although cardiac mucosa lacks the goblet cells commonly required for a histologic diagnosis of intestinal metaplasia, cardiac mucosa has many molecular features of an intestinal-type mucosa, and appears to be the precursor of intestinal metaplasia with goblet cells...
April 18, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29671159/clinical-guidelines-update-on-the-diagnosis-and-management-of-barrett-s-esophagus
#7
REVIEW
Michelle Clermont, Gary W Falk
Barrett's esophagus is a condition in which metaplastic columnar epithelium replaces stratified squamous epithelium in the distal esophagus. This condition occurs due to chronic gastroesophageal reflux disease and is a risk factor for the development of esophageal adenocarcinoma. Multiple clinical guidelines have been published around the world in recent years to assist gastroenterologists in the management of these patients and have evolved as new data have become available. While some information such as surveillance technique has not drastically changed, there has been an evolution over the years in diagnostic criteria, screening and endoscopic therapy with a variety of subtle differences among the different guidelines...
April 18, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29671158/barrett-s-esophagus-and-esophageal-adenocarcinoma-how-common-are-they-really
#8
REVIEW
Aaron P Thrift
Since the early 1970s, the incidence of esophageal adenocarcinoma (EA) has increased dramatically in most Western populations while the incidence of esophageal squamous cell carcinoma has decreased. As a result, EA has become the predominant subtype of esophageal cancer in North America and Europe and is an important contributor to overall cancer mortality. Barrett's esophagus (BE), a metaplastic columnar epithelium of the distal esophagus, is the known precursor lesion for EA. EA and BE occur more frequently in white men over 50 years old, as well as in people with frequent symptoms of gastroesophageal reflux, in smokers, and in people who are obese...
April 18, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29671157/natural-history-of-the-post-ablation-esophagus
#9
REVIEW
Craig C Reed, Nicholas J Shaheen
Endoscopic ablative therapy including radiofrequency ablation (RFA) represents the preferred management strategy for dysplastic Barrett's esophagus (BE) and appears to diminish the risk of developing esophageal adenocarcinoma (EAC). Limited data describe the natural history of the post-ablation esophagus. Recent findings demonstrate that recurrent intestinal metaplasia (IM) following RFA is relatively frequent. However, dysplastic BE and EAC subsequent to the complete eradication of intestinal metaplasia (CEIM) are uncommon...
April 18, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29666803/personalized-therapy-based-on-image-for-esophageal-or-gastroesophageal-junction-adenocarcinoma
#10
REVIEW
Kazuto Harada, Dilsa Mizrak Kaya, Anthony Lopez, Hideo Baba, Jaffer A Ajani
Preoperative therapy is the gold standard for esophageal or gastroesophageal junction adenocarcinoma. Positron emission tomography (PET) is not only essential for tumor staging, but changes in glucose consumption correspond with response to therapy and correlated with prognosis. Therefore, with further refinement, PET parameter can serve as a tool for personalized therapy. For instance, the Municon trials suggested the possibility of PET-response guided therapy for esophageal adenocarcinoma (EAC) patients, however there are limitations...
February 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29666799/comparison-of-two-major-staging-systems-of-esophageal-cancer-toward-more-practical-common-scale-for-tumor-staging
#11
REVIEW
Harushi Udagawa, Masaki Ueno
The latest 8th edition of TNM Classification of Malignant Tumours by Union for International Cancer Control (UICC) and 11th edition of Japanese Classification of Esophageal Cancer by Japan Esophageal Society (JES) are the two major classifications widely accepted as tools for clinical staging of esophageal cancer. Both systems consist of three main categories, i.e., T, N, and M, but large difference exists between the two. JES system has more detailed sub-classification of T1 tumors reflecting meticulous work by Japanese investigators on superficial esophageal cancer...
February 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29662932/combined-extensive-esophageal-squamous-papillomas-and-florid-cardiac-gland-hyperplasia-in-a-patient-with-adenocarcinoma
#12
Takanori Suganuma, Han-Seung Yoon
We report a rare case of extensive esophageal squamous papillomas (ESPs) involving the entire esophagus and florid cardiac gland hyperplasia involving only the lower esophagus in a 39-year-old woman with heartburn and epigastric distress for the past 2 years. Previous esophagogastroduodenoscopy showed multiple ESPs involving the entire esophagus extending 38 cm from the esophageal orifice to the esophagogastric junction (EGJ). Additionally, prominent cardiac gland hyperplasia over the esophageal posterior wall was exhibited extending 12 cm from the mid-esophagus to the EGJ...
March 2018: GE Portuguese Journal of Gastroenterology
https://www.readbyqxmd.com/read/29662006/hyperinsulinemia-promotes-esophageal-cancer-development-in-a-surgically-induced-duodeno-esophageal-reflux-murine-model
#13
Diletta Arcidiacono, Arben Dedja, Cinzia Giacometti, Matteo Fassan, Daniele Nucci, Simona Francia, Federico Fabris, Alice Zaramella, Emily J Gallagher, Mauro Cassaro, Massimo Rugge, Derek LeRoith, Alfredo Alberti, Stefano Realdon
Hyperinsulinemia could have a role in the growing incidence of esophageal adenocarcinoma (EAC) and its pre-cancerous lesion, Barrett's Esophagus, a possible consequence of Gastro-Esophageal Reflux Disease. Obesity is known to mediate esophageal carcinogenesis through different mechanisms including insulin-resistance leading to hyperinsulinemia, which may mediate cancer progression via the insulin/insulin-like growth factor axis. We used the hyperinsulinemic non-obese FVB/N (Friend leukemia virus B strain) MKR (muscle (M)-IGF1R-lysine (K)-arginine (R) mouse model to evaluate the exclusive role of hyperinsulinemia in the pathogenesis of EAC related to duodeno-esophageal reflux...
April 14, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29656821/is-less-really-more-endoscopic-mucosal-resection-versus-esophagectomy-for-submucosal-esophageal-adenocarcinoma
#14
EDITORIAL
Siva Raja, Alejandro C Bribriesco, Madhu R Sanaka
No abstract text is available yet for this article.
March 16, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29628770/validation-of-a-risk-prediction-model-for-barrett-s-esophagus-in-an-australian-population
#15
Colin J Ireland, Andrea L Gordon, Sarah K Thompson, David I Watson, David C Whiteman, Richard L Reed, Adrian Esterman
Background: Esophageal adenocarcinoma is a disease that has a high mortality rate, the only known precursor being Barrett's esophagus (BE). While screening for BE is not cost-effective at the population level, targeted screening might be beneficial. We have developed a risk prediction model to identify people with BE, and here we present the external validation of this model. Materials and methods: A cohort study was undertaken to validate a risk prediction model for BE...
2018: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/29627387/predictors-of-nodal-metastases-for-clinical-t2n0-esophageal-adenocarcinoma
#16
Arianna Barbetta, Francisco Schlottmann, Tamar Nobel, David B Sewell, Meier Hsu, Kay See Tan, Hans Gerdes, Pari Shah, Manjit S Bains, Matthew Bott, James M Isbell, David R Jones, Daniela Molena
BACKGROUND: Induction therapy has not been proven to be beneficial for patients with clinical T2N0 esophageal adenocarcinoma. Surgery alone is associated with disappointing survival for patients found to have nodal disease on final pathologic examination. The aim of this study was to identify factors that predict pathologic nodal involvement in patients with endoscopic ultrasound (EUS)-proven T2N0 esophageal adenocarcinoma. METHODS: We retrospectively reviewed patients with EUS-staged T2N0 (uT2N0) esophageal adenocarcinoma treated with surgery alone...
April 5, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29626424/multifocal-nitrous-oxide-cryoballoon-ablation-with-or-without-emr-for-treatment-of-neoplastic-barrett-s-esophagus
#17
Marcia Irene Canto, Nicholas J Shaheen, Jose Alejandro Almario, Lysandra Voltaggio, Elizabeth Montgomery, Charles J Lightdale
BACKGROUND AND AIMS: Endoscopic cryotherapy can eradicate neoplastic Barrett's esophagus (BE). A new contact cryoballoon focal ablation system (CbFAS)) freezes esophageal mucosa with nitrous oxide. We studied the safety and efficacy of CbFAS for complete eradication of neoplastic Barrett's esophagus. METHODS: In a prospective clinical trial, consecutive BE patients with confirmed neoplasia (low-grade dysplasia LGD, high-grade dysplasia HGD, and/or intramucosal adenocarcinoma ImCA), at least 1 cm of BE, with or without prior ablation, were treated with a dose 10 seconds of spray per site...
April 4, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29616242/dietary-impact-on-esophageal-cancer-in-humans-a-review
#18
REVIEW
Rachna Khosla Sardana, Navnidhi Chhikara, Beenu Tanwar, Anil Panghal
Cancer is the abnormal growth of cells that tend to proliferate in an uncontrolled way. About 32.6 million people in the world are affected by different types of cancer; 456 000 have esophageal cancer, which is the eighth most common cancer and the sixth most common cause of cancer-related deaths with a toll of 400 000 in 2012. About 80% of cases were reported from the less developed regions of the world. An incidence ratio of 2.4 : 1 for men and women reveals the gender disparity. Esophageal cancer is mainly of two types, namely, squamous cell carcinoma and adenocarcinoma...
April 4, 2018: Food & Function
https://www.readbyqxmd.com/read/29609065/low-incidence-of-esophageal-adenocarcinoma-after-eradication-of-helicobacter-pylori-in-japan
#19
Susumu Take, Motowo Mizuno, Kuniharu Ishiki, Fumihiro Hamada, Tomowo Yoshida, Kenji Yokota, Hiroyuki Okada
No abstract text is available yet for this article.
March 30, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29609018/curative-resection-of-advanced-esophageal-cancer-with-metachronous-stage-iv-breast-cancer-a-case-report
#20
Yusuke Gokon, Tadashi Sakurai, Fumiyoshi Fujishima, Yusuke Taniyama, Takahiro Heishi, Hiroshi Okamoto, Shota Maruyama, Hirotaka Ishida, Yu Onodera, Hironobu Sasano, Takashi Kamei
INTRODUCTION: Recent studies have shown the safety and efficacy of curative resection of esophageal cancer with multiple primary cancers. However, our literature search revealed no curative surgery cases for esophageal cancer in patients with multiple primary cancers with distant metastasis. CASE PRESENTATION: A 75-year-old woman visited our hospital with dysphagia. She had a history of breast cancer with multiple bone metastasis. Esophagogastroduodenoscopy revealed a circumferential mass in the upper intrathoracic esophagus...
March 19, 2018: International Journal of Surgery Case Reports
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