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Esophageal adenocarcinoma

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https://www.readbyqxmd.com/read/29025018/the-association-between-waterpipe-smoking-and-gastroesophageal-reflux-disease
#1
Arash Etemadi, Abdullah Gandomkar, Neal D Freedman, Mohsen Moghadami, Mohammad Reza Fattahi, Hossein Poustchi, Farhad Islami, Paolo Boffetta, Sanford M Dawsey, Christian C Abnet, Reza Malekzadeh
Background: Unlike cigarettes, there is little information about the association between other tobacco products and the risk of gastroesophageal reflux disease (GERD) and esophageal adenocarcinoma. Methods: We used the baseline data from the Pars Cohort Study conducted in southern Iran. In 2012, 9264 local residents between 40 and 75 years old were enrolled, with detailed information about lifestyle, including duration and frequency of tobacco use. GERD was defined based on questions assessing heartburn and regurgitation in the past 12 months, frequency and severity...
August 19, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29022493/immunonutrition-before-esophagectomy-impact-on-immune-surveillance-mechanisms
#2
Marco Scarpa, Andromachi Kotsafti, Matteo Fassan, Melania Scarpa, Francesco Cavallin, Teresa Nardi, Eleonora Pinto, Rita Alfieri, Matteo Cagol, Marco Agostini, Massimo Rugge, Ignazio Castagliuolo, Carlo Castoro
Preoperative oral immunonutrition was demonstrated to improve immune response and to decrease the infection rate in patients with cancer. This study aimed to assess how immunonutrition could influence the immune cell response in the mucosal microenvironment of esophageal adenocarcinoma. Therefore, A prospective cohort of consecutive patients undergoing esophagectomy for esophageal adenocarcinoma was enrolled. A subgroup of them was given preoperative oral immunonutrition with Oral Impact® and was compared to those who received no preoperative supplementation...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29022485/prevalence-of-%C3%AE-iii-tubulin-tubb3-expression-in-human-normal-tissues-and-cancers
#3
Fermín Person, Waldemar Wilczak, Claudia Hube-Magg, Christoph Burdelski, Christina Möller-Koop, Ronald Simon, Mercedes Noriega, Guido Sauter, Stefan Steurer, Susanne Burdak-Rothkamm, Frank Jacobsen
Microtubules are multifunctional cytoskeletal proteins that are involved in crucial cellular roles including maintenance of cell shape, intracellular transport, meiosis, and mitosis. Class III beta-tubulin (βIII-tubulin, also known as TUBB3) is a microtubule protein, normally expressed in cells of neuronal origin. Its expression was also reported in various other tumor types, such as several types of lung cancer, ovarian cancer, and esophageal cancer. TUBB3 is of clinical relevance as overexpression has been linked to poor response to microtubule-targeting anti-cancer drugs such as taxanes...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29020052/effects-of-socioeconomic-status-on-esophageal-adenocarcinoma-stage-at-diagnosis-receipt-of-treatment-and-survival-a-population-based-cohort-study
#4
Hla-Hla Thein, Kika Anyiwe, Nathaniel Jembere, Brian Yu, Prithwish De, Craig C Earle
The incidence of esophageal adenocarcinoma (EAC) is increasing worldwide and has overtaken squamous histology in occurrence. We studied the impact of socioeconomic status (SES) on EAC stage at diagnosis, receipt of treatment, and survival. A population-based retrospective cohort study was conducted using Ontario Cancer Registry-linked administrative health data. Multinomial logistic regression was used to examine the association between SES (income quintile) and stage at EAC diagnosis and EAC treatment. Survival times following EAC diagnosis were estimated using Kaplan-Meier method...
2017: PloS One
https://www.readbyqxmd.com/read/29019570/thoraco-laparoscopic-esophagectomy-thoracic-stage-in-prone-position
#5
Carlos Bernardo Cola, Flávio Duarte Sabino, Carlos Eduardo Pinto, Maria Ribeiro Morard, Pedro Portari, Tereza Guedes
OBJECTIVE: to analyze the National Cancer Institute Abdominopelvic Division (INCA / MS/HC I) initial experience with thoraco-laparoscopic esophagectomy with thoracic stage in prone position. METHODS: we studied 19 consecutive thoraco-laparoscopic esophagectomies from may 2012 to august 2014, including ten patients with squamous cells carcinoma (five of the middle third and five of the lower third) and nine cases of gastroesophageal junction adenocarcinoma (six Siewert I and three Siewert II)...
September 2017: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/29016405/definition-of-barrett-esophagus-in-the-united-states-support-for-retention-of-a-requirement-for-goblet-cells
#6
Kevan J Salimian, Kevin M Waters, Ogechukwu Eze, Maryam K Pezhouh, Yaman Tarabishy, Eun-Ji Shin, Marcia I Canto, Lysandra Voltaggio, Elizabeth A Montgomery
Barrett esophagus (BE) predisposes patients to the development of esophageal adenocarcinoma (EAC). However, the global definition of BE is controversial. Pathologists in Europe and the United States require intestinal metaplasia (IM) within columnar-lined mucosa (CLM) in the tubular esophagus to diagnose BE, whereas in the UK and Japan only the presence of CLM is required. To aid in establishing an appropriate definition for BE, we evaluated whether IM accompanies EAC in a US patient cohort. We examined a series of 139 consecutive patients who underwent endoscopic mucosal resections or esophagectomies for EAC performed at a US tertiary care center...
October 9, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28985034/esophageal-adenocarcinoma-microenvironment-peritumoral-adipose-tissue-effects-associated-with-chemoresistance
#7
Amedeo Carraro, Elisabetta Trevellin, Matteo Fassan, Andromachi Kotsafti, Francesca Lunardi, Andrea Porzionato, Luigi Dall'Olmo, Matteo Cagol, Rita Alfieri, Veronica Macchi, Umberto Tedeschi, Fiorella Calabrese, Massimo Rugge, Carlo Castoro, Roberto Vettor, Marco Scarpa
Peritumoral microenvironment affects cancer development and chemoresistance, and visceral adipose tissue may play a critical role. We aimed to identify depot-specific adipose characteristics associated with carcinogenesis and resistance to neoadjuvant therapy, in esophageal adenocarcinoma (EAC). We analysed: 1) the peritumoral adipose tissue of rats, following the induction of esophageal carcinogenesis; 2) the peritumoral and distal (omental) adipose tissue of patients affected by EAC; 3) adipose-derived stem cells (ADSCs) isolated from healthy patients and treated with conditioned medium (CM), collected from tumoral and adipose tissue of patients with EAC...
October 6, 2017: Cancer Science
https://www.readbyqxmd.com/read/28980899/oesophageal-disease-in-systemic-sclerosis-does-heritability-play-a-role
#8
Tracy Frech, Latifa Fakoya, Andrew J Gawron, Jathine Wong, Mary Beth Scholand, Allen Sawitzke, Kathryn Peterson
OBJECTIVES: In systemic sclerosis (SSc) the most common gastrointestinal tract (GIT) complaint is gastroesophageal reflux disease (GERD), which may contribute to oesophagitis, stricture, Barrett's oesophagus, and oesophageal adenocarcinoma. We used a genealogical resource the Utah Population Database (UPDB) to analyse SSc pedigrees for hereditability of oesophageal disease. METHODS: SSc, GERD, oesophagitis, stricture, Barrett's, and oesophageal adenocarcinoma were defined by ICD Ninth and Tenth Revision codes...
October 2, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28980268/processing-and-analyzing-human-microbiome-data
#9
Xuan Zhu, Jian Wang, Cielito Reyes-Gibby, Sanjay Shete
The human microbiome is associated with complex disorders such as diabetes, cancer, obesity and cardiovascular disorders. Recent technological developments have allowed researchers to fully quantify the composition of the microbiome using culture-independent approaches, resulting in a large amount of microbiome data, which provide invaluable opportunities to assess the important contributions of the microbiome to human health and disease. In this chapter, we discuss and evaluate multiple statistical approaches for processing, summarizing, and analyzing microbiome data...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28978001/tenascin-c-and-fibronectin-in-normal-esophageal-mucosa-barrett-s-esophagus-dysplasia-and-adenocarcinoma
#10
Joni Leppänen, Sara Bogdanoff, Petri P Lehenkari, Juha Saarnio, Joonas H Kauppila, Tuomo J Karttunen, Heikki Huhta, Olli Helminen
BACKGROUND: Tenascin-C and fibronectin are adhesive glycoproteins modulating the structure of the extracellular matrix and cellular functions. Their expression and function in esophageal adenocarcinoma is poorly known. The aim of this study was to evaluate the expression of tenascin-C and fibronectin in esophageal adenocarcinoma and its precursor stages. RESULTS: Stromal tenascin-C and fibronectin expression were found in all evaluated lesion types. Expression of both molecules increased from gastric metaplasia towards adenocarcinoma (p<0...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28975518/outcome-with-primary-en-bloc-esophagectomy-for-submucosal-esophageal-adenocarcinoma
#11
Katrin Schwameis, Kyle M Green, Stephanie G Worrell, Jamil Samaan, Shannon Cooper, Sergei Tatishchev, Daniel S Oh, Jeffrey A Hagen, Steven R DeMeester
BACKGROUND: Intramucosal esophageal adenocarcinoma can be reliably treated endoscopically. Controversy exists about the use of endotherapy versus esophagectomy for submucosal tumors. Increasingly endotherapy is considered for submucosal tumors in part because of the presumed high mortality with esophagectomy and the perceived poor prognosis in patients with nodal disease. This study was designed to assess survival following primary en bloc esophagectomy (EBE) in patients with submucosal esophageal adenocarcinoma (EAC)...
October 3, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28974564/corrigendum-a-comparative-analysis-of-whole-genome-sequencing-of-esophageal-adenocarcinoma-pre-and-post-chemotherapy
#12
Ayesha Noorani, Jan Bornschein, Andy G Lynch, Maria Secrier, Achilleas Achilleos, Matthew Eldridge, Lawrence Bower, Jamie M J Weaver, Jason Crawte, Chin-Ann Ong, Nicholas Shannon, Shona MacRae, Nicola Grehan, Barbara Nutzinger, Maria O'Donovan, Richard Hardwick, Simon Tavaré, Rebecca C Fitzgerald
No abstract text is available yet for this article.
October 2017: Genome Research
https://www.readbyqxmd.com/read/28970723/high-yield-reproducible-rat-model-recapitulating-human-barrett-s-carcinogenesis
#13
Daisuke Matsui, Ashten N Omstead, Juliann E Kosovec, Yoshihiro Komatsu, Emily J Lloyd, Hailey Raphael, Ronan J Kelly, Ali H Zaidi, Blair A Jobe
AIM: To efficiently replicate the biology and pathogenesis of human esophageal adenocarcinoma (EAC) using the modified Levrat model of end-to-side esophagojejunostomy. METHODS: End-to-side esophagojejunostomy was performed on rats to induce gastroduodenoesophageal reflux to develop EAC. Animals were randomly selected and serially euthanized at 10 (n = 6), 17 (n = 8), 24 (n = 9), 31 (n = 6), 38 (n = 6), and 40 (n = 6) wk postoperatively. The esophagi were harvested for downstream histopathology and gene expression...
September 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28969923/diagnosis-and-endoscopic-management-of-barrett-s-esophagus-an-italian-experts-opinion-based-document
#14
Guido Costamagna, Giorgio Battaglia, Alessandro Repici, Roberto Fiocca, Massimo Rugge, Cristiano Spada, Vincenzo Villanacci
BACKGROUND: Barrett's esophagus (BE) is recognized as a risk factor for esophageal adenocarcinoma. An expert panel was organized in Italy with the aim of drafting a series of statements on BE to guide diagnosis and management of patients with BE. METHODS: The working Group Coordinators worked on a literature search to identify key topics regarding critical steps of the endoscopic approach to BE. Based on the search and their expert opinion, a list of most meaningful questions was prepared and emailed to all members who were asked to vote the questions...
September 1, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28968550/esophageal-adenocarcinoma-derived-extracellular-vesicle-micrornas-induce-a-neoplastic-phenotype-in-gastric-organoids
#15
Xiquan Ke, Rong Yan, Zhenguo Sun, Yulan Cheng, Amy Meltzer, Nonghua Lu, Xu Shu, Zhe Wang, Binbin Huang, Xi Liu, Zhixiong Wang, Jee Hoon Song, Christopher K Ng, Sariat Ibrahim, John M Abraham, Eun Ji Shin, Shuixiang He, Stephen J Meltzer
There have been no reports describing the effects of cancer cell-derived extracellular vesicles (EVs) on three-dimensional organoids. In this study, we delineated the proneoplastic effects of esophageal adenocarcinoma (EAC)-derived EVs on gastric organoids (gastroids) and elucidated molecular mechanisms underlying these effects. EVs were identified using PKH-67 staining. Morphologic changes, Ki-67 immunochemistry, cell viability, growth rates, and expression levels of miR-25 and miR-210, as well as of their target mRNAs, were determined in gastroids co-cultured with EAC-derived extracellular vesicles (c-EVs)...
September 29, 2017: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/28957898/recurrent-esophageal-adenocarcinoma-with-circumferential-involvement-of-the-trachea
#16
Pichapong Tunsupon, Kassem Harris, Jessie Bower, Abdul Hamid Alraiyes
No abstract text is available yet for this article.
October 2017: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/28954322/-french-comment-on-article-exploring-diagnostic-and-therapeutic-implications-of-endoscopic-mucosal-resection-in-endoscopic-ultrasound-staged-t2-esophageal-adenocarcinoma
#17
https://www.readbyqxmd.com/read/28954313/endoscopic-resection-in-esophageal-adenocarcinoma-a-basic-requirement-for-future-management-algorithms
#18
Neil Gupta, Prateek Sharma
No abstract text is available yet for this article.
October 2017: Endoscopy
https://www.readbyqxmd.com/read/28954045/low-prevalence-of-barrett-s-esophagus-in-a-risk-area-for-esophageal-cancer-in-south-of-brazil
#19
Diego Michelon DE Carli, Amanda Faria de Araujo, Renato Borges Fagundes
BACKGROUND: Barrett's esophagus a complication of gastroesophageal reflux disease (GERD) is a precursor of esophageal adenocarcinoma. The incidence of esophageal adenocarcinoma has been increasing in most Western countries. Rio Grande do Sul (RS), the Southernmost state of Brazil has the highest rates of esophageal cancer with low prevalence of esophageal adenocarcinoma. OBJECTIVE: To investigate the prevalence of Barrett's esophagus among patients underwent to upper gastrointestinal endoscopy in the last 5 years...
September 21, 2017: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/28948524/discrepancy-between-clinical-and-pathologic-nodal-status-of-esophageal-cancer-and-impact-on-prognosis-and-therapeutic-strategy
#20
Sheraz R Markar, Caroline Gronnier, Arnaud Pasquer, Alain Duhamel, Hélène Behal, Jérémie Théreaux, Johan Gagnière, Gil Lebreton, Cécile Brigand, Florence Renaud, Guillaume Piessen, Bernard Meunier, Denis Collet, Christophe Mariette
BACKGROUND: The impact of discrepancies between clinical (c) and pathologic (p) stages of esophageal cancer remains a poorly understood issue. This study aimed to compare the prognosis of patient groups treated by primary surgery including clinical N0/pathologic N0 (cN0pN0), clinical N0/pathologic N+ (cN0pN+), clinical N+/pathologic N0 (cN+pN0), and clinical N+/pathologic N+ (cN+pN+). METHODS: Data were collected from 30 European centers during the years 2000 to 2010...
September 25, 2017: Annals of Surgical Oncology
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