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Barretts esophagus

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https://www.readbyqxmd.com/read/29458154/the-effect-of-endoscopic-surveillance-in-patients-with-barrett-s-esophagus-a-systematic-review-and-meta-analysis
#1
Don Chamil Codipilly, Apoorva Krishna Chandar, Siddharth Singh, Sachin Wani, Nicholas J Shaheen, John M Inadomi, Amitabh Chak, Prasad G Iyer
BACKGROUND & AIMS: Guidelines recommend endoscopic surveillance of patients with Barrett's esophagus (BE) to identify those with dysplasia (a precursor of carcinoma) or early-stage esophageal adenocarcinoma (EAC), who can be treated endoscopically. However, it is unclear whether surveillance increases survival times of patients with BE. We performed a systematic review and meta-analysis to qualitatively and quantitatively examine evidence for the association of endoscopic surveillance in patients with BE with survival and other outcomes...
February 16, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29458152/controversies-in-endoscopic-eradication-therapy-for-barrett-s-esophagus
#2
Srinadh Komanduri, V Raman Muthusamy, Sachin Wani
Advances in Endoscopic Eradication Therapy for Barrett's Esophagus associated neoplasia have resulted in a significant paradigm shift in diagnosis and management of this complex disease. A robust body of literature critically evaluating outcomes of resection and ablative strategies has allowed gastroenterologists to make quality, evidence based decisions for their patients. Despite this progress, there are still many unanswered questions and challenges that remain. Ultimately, identification of a cost-effective screening modality, biomarkers for risk stratification, and strides to eliminate post surveillance endoscopy after EET are essential to reach our long term goal for eradication of esophageal adenocarcinoma...
February 16, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29454095/an-esophageal-adenocarcinoma-susceptibility-locus-at-9q22-also-confers-risk-to-esophageal-squamous-cell-carcinoma-by-regulating-the-function-of-barx1
#3
Caiwang Yan, Yong Ji, Tongtong Huang, Fei Yu, Yong Gao, Yayun Gu, Qi Qi, Jiangbo Du, Juncheng Dai, Hongxia Ma, Guangfu Jin
Genome wide association studies (GWAS) have identified a series of genetic variants associated with the risk of esophageal adenocarcinoma (EAC)/Barrett's esophagus (BE), which was different from those loci for esophageal squamous cell carcinoma (ESCC). It is important to evaluate whether these susceptibility loci for EAC/BE are also implicated in ESCC development. In the current study, we analyzed genetic variants at 3p13, 9q22, 16q24 and 19p13 in a case-control study including 2139 ESCC patients and 2463 cancer-free controls in a Chinese population, and further characterized the biological relevance of genetic variants by functional assays...
February 14, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29449669/predictive-biomarkers-of-gastroesophageal-reflux-disease-and-barrett-s-esophagus-in-world-trade-center-exposed-firefighters-a-15-year-longitudinal-study
#4
Syed H Haider, Sophia Kwon, Rachel Lam, Audrey K Lee, Erin J Caraher, George Crowley, Liqun Zhang, Theresa M Schwartz, Rachel Zeig-Owens, Mengling Liu, David J Prezant, Anna Nolan
Gastroesophageal reflux disease (GERD) and Barrett's Esophagus (BE), which are prevalent in the World Trade Center (WTC) exposed and general populations, negatively impact quality of life and cost of healthcare. GERD, a risk factor of BE, is linked to obstructive airways disease (OAD). We aim to identify serum biomarkers of GERD/BE, and assess the respiratory and clinical phenotype of a longitudinal cohort of never-smoking, male, WTC-exposed rescue workers presenting with pulmonary symptoms. Biomarkers collected soon after WTC-exposure were evaluated in optimized predictive models of GERD/BE...
February 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29447244/influence-of-hiatal-hernia-and-male-sex-on-the-relationship-between-alcohol-intake-and-occurrence-of-barrett-s-esophagus
#5
Atsuhiro Masuda, Tsuyoshi Fujita, Manabu Murakami, Yukinao Yamazaki, Masao Kobayashi, Shuichi Terao, Tsuyoshi Sanuki, Akihiko Okada, Masayasu Adachi, Hideyuki Shiomi, Yoshifumi Arisaka, Hiromu Kutsumi, Eiji Umegaki, Takeshi Azuma
BACKGROUND: The association of alcohol intake with the incidence of Barrett's esophagus (BE) has been inconsistent. Although hiatal hernia and male sex are well-known risk factors of BE, its effect on the association of alcohol intake with the incidence of BE remains unknown. AIM: To investigate whether the influence of alcohol intake on the occurrence of BE might differ depending on male sex and presence of hiatal hernia. METHODS: We utilized a database of 8031 patients that underwent upper endoscopy for health screening in a prospective, multicenter, cohort study (the Upper Gastro Intestinal Disease study)...
2018: PloS One
https://www.readbyqxmd.com/read/29440928/early-diagnostic-potential-of-apc-hypermethylation-in-esophageal-cancer
#6
Bujiang Wang, Haojun Song, Haizhong Jiang, Yangbo Fu, Xiaoyun Ding, Chongchang Zhou
Background: The hypermethylation of APC gene is observed in various cancers, including esophageal cancer (EC). However, the association between APC methylation and the initiation and progression of EC is poorly understood. Purpose and methods: The current study systematically reviewed studies on abnormal methylation of APC in EC and quantitatively synthesized 18 studies by meta-analysis involving 1008 ECs, 570 Barrett's esophagus (BE), and 782 controls. Results: Our results showed higher methylation of APC in EC (OR = 23...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29435819/expanding-role-of-third-space-endoscopy-in-the-management-of-esophageal-diseases
#7
REVIEW
Dennis Yang, Peter V Draganov
OPINION STATEMENT: "Third space" endoscopy, also commonly referred as submucosal endoscopy, is founded on the principle that the deeper layers of the gastrointestinal (GI) tract can be accessed by tunneling in the submucosal space without compromising the integrity of the overlying mucosa. Peroral endoscopic myotomy (POEM), endoscopic submucosal dissection (ESD), and submucosal tunneling endoscopic resection (STER) are innovative techniques within the field of third space endoscopy in the management of esophageal disorders...
February 12, 2018: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/29435755/surgical-management-of-gastroesophageal-reflux-disease-in-patients-with-systemic-sclerosis
#8
Jingliang Yan, Andrew T Strong, Gautam Sharma, Scott Gabbard, Prashanti Thota, John Rodriguez, Matthew Kroh
BACKGROUND: Systemic sclerosis (scleroderma) is frequently associated with both gastroesophageal reflux disease (GERD) and simultaneous esophageal dysmotility. Anti-reflux procedures in this patient population must account for the existing physiology of each patient and likely disease progression. We aim to compare perioperative and intermediate outcomes of fundoplication versus gastric bypass for the treatment of GERD. METHODS: After IRB approval, patients with systemic sclerosis undergoing fundoplication or gastric bypass for the treatment of GERD from 2004 to 2016 were identified...
February 12, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29435310/risk-of-histologic-barrett-s-esophagus-between-african-americans-and-non-hispanic-whites-a-meta-analysis
#9
Ahmad Alkaddour, Carlos Palacio, Kenneth J Vega
Background: Barrett's esophagus (BE) is rare in African Americans (AA). However, the risk difference magnitude in histologic BE prevalence between AA and non-Hispanic whites (nHw) has not been quantified to date. Objective: The objective of this article is to determine the degree of histologic BE risk difference between AA and nHw. Methods: PubMed, Web of Science and EMBASE were searched for studies reporting histologic BE in AA/nHw for inclusion...
February 2018: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29432922/use-of-appropriate-surveillance-for-patients-with-non-dysplastic-barrett-s-esophagus
#10
Anna Tavakkoli, Henry D Appelman, David G Beer, Chaitra Madiyal, Maryam Khodadost, Kimberly Nofz, Val Metko, Grace Elta, Thomas Wang, Joel H Rubenstein
BACKGROUND & AIMS: Barrett's Esophagus (BE) is a precursor to esophageal adenocarcinoma (EAC). Guidelines recommend that patients with nondysplastic BE (NDBE) undergo surveillance endoscopy every 3-5 years. We aimed to identify factors associated with surveillance endoscopy of patients with NDBE and identify trends in appropriate surveillance endoscopy of NDBE at a large tertiary care center. METHODS: We performed a retrospective analysis of data from a Barrett's Esophagus Registry, identifying patients with NDBE who underwent endoscopy in 2002 or later...
February 9, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29427733/extraesophageal-symptoms-and-diseases-attributed-to-gerd-where-is-the-pendulum-swinging-now
#11
Michael F Vaezi, David Katzka, Frank Zerbib
BACKGROUND AND AIMS: The purpose of this review is to outline the recent developments in the field of extraesophageal reflux disease and provide clinically relevant recommendations. METHODS: The recommendations outlined in this review are based on expert opinion and on relevant publications from PubMed and EMbase. The Clinical Practice Updates Committee of the American Gastroenterological Association proposes the following recommendations: 1. The role of a gastroenterologist in patients referred for evaluation of suspected extra esophageal symptom is to assess for gastroesophageal etiologies that could contribute to the presenting symptoms...
February 7, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29417867/bioinformatic-analyses-of-microrna-targeted-genes-and-microarray-identified-genes-correlated-with-barrett-s-esophagus
#12
Jing Lv, Jijun Liu, Lei Guo, Jun Zhang, Yan Cheng, Chu Chen, Heping Zhao, Jihan Wang
Barrett's esophagus (BE) is defined as a metaplasia condition in the distal esophagus, in which the native squamous epithelium lining is replaced by a columnar epithelium with or without intestinal metaplasia. It is commonly accepted that BE is a precancerous lesion for esophageal adenocarcinoma. The aim of this study was to investigate the aberrant microRNAs (miRNAs) and differentially expressed genes (DEGs) associated with BE based on online microarray datasets. One miRNA and five gene expression profiling datasets were retrieved from the Gene Expression Omnibus Database...
February 8, 2018: Cell Cycle
https://www.readbyqxmd.com/read/29410080/incremental-yield-of-dysplasia-detection-in-barrett-s-esophagus-using-volumetric-laser-endomicroscopy-with-and-without-laser-marking-compared-with-a-standardized-random-biopsy-protocol
#13
Mohammad Alshelleh, Sumant Inamdar, Matthew McKinley, Molly Stewart, Jeffrey S Novak, Ronald E Greenberg, Keith Sultan, Bethany Devito, Mary Cheung, Maurice A Cerulli, Larry S Miller, Divyesh V Sejpal, Anil K Vegesna, Arvind J Trindade
BACKGROUND AND AIMS: Volumetric laser endomicroscopy (VLE) is a new wide field advanced imaging technology for Barrett's esophagus (BE). No data exist on incremental yield of dysplasia detection. Our aim is to report the incremental yield of dysplasia detection in BE using VLE. METHODS: This is a retrospective study from a prospectively maintained database from 2011-2017 comparing the dysplasia yield of 4 different surveillance strategies in an academic BE tertiary care referral center...
February 2, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29397943/endoscopic-eradication-therapy-for-patients-with-barrett-s-esophagus-associated-dysplasia-and-intramucosal-cancer
#14
Sachin Wani, Bashar Qumseya, Shahnaz Sultan, Deepak Agrawal, Vinay Chandrashekara, Ben Harnke, Shivangi Kothari, Martin McCarter, Aasma Shaukat, Amy Wang, Julie Yang, John Dewitt
No abstract text is available yet for this article.
February 1, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29384778/whole-genome-methylation-analysis-of-nondysplastic-barrett-esophagus-that-progresses-to-invasive-cancer
#15
Mark P Dilworth, Tom Nieto, Jo D Stockton, Celina M Whalley, Louise Tee, Jonathan D James, Fergus Noble, Tim J Underwood, Michael T Hallissey, Rahul Hejmadi, Nigel Trudgill, Olga Tucker, Andrew D Beggs
OBJECTIVE: To investigate differences in methylation between patients with nondysplastic Barrett esophagus who progress to invasive adenocarcinoma and those who do not. BACKGROUND: Identifying patients with nondysplastic Barrett esophagus who progress to invasive adenocarcinoma remains a challenge. Previous studies have demonstrated the potential utility of epigenetic markers for identifying this group. METHODS: A whole genome methylation interrogation using the Illumina HumanMethylation 450 array of patients with nondysplastic Barrett esophagus who either develop adenocarcinoma or remain static, with validation of findings by bisulfite pyrosequencing...
January 30, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29375745/vitamin-d-in-esophageal-cancer-is-there-a-role-for-chemoprevention
#16
REVIEW
Carol Rouphael, Afrin Kamal, Madhusudhan R Sanaka, Prashanthi N Thota
Vitamin D has emerged as a promising anti-cancer agent due to its diverse biological effects on tumor differentiation, apoptosis and suppression of cellular proliferation. Current evidence suggests a protective role of vitamin D in colon cancer. The effect of vitamin D on esophageal cancer remains controversial. Multiple studies investigated the association between vitamin D and esophageal cancer, employing different modes of assessment of vitamin D status such as serum 25-hydroxyvitamin D levels, vitamin D dietary intake or exposure to ultraviolet B (UVB) radiation...
January 15, 2018: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29370762/circular-stripes-were-more-common-in-barrett-s-esophagus-after-acetic-acid-staining
#17
Yating Sun, Shiyang Ma, Li Fang, Jinhai Wang, Lei Dong
BACKGROUND: The diagnosis of Barrett's esophagus (BE) is disturbed by numerous factors, including correct gastroesophageal junction judgment, the initial location of the Z-line and the biopsy result above it. The acetic acid (AA) could help to diagnose BE better than high resolution imaging technology or magnifying endoscopy, by providing enhanced contrast of different epithelium. We have noticed AA could produce multiple white circular lines, forming circular stripes (CS), at lower esophagus, which hasn't been reported by others...
January 25, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29369237/comparative-assessment-of-patient-preferences-and-tolerability-in-barrett-esophagus-screening-results-from-a-randomized-trial
#18
Christopher H Blevins, Jason S Egginton, Nilay D Shah, Michele L Johnson, Prasad G Iyer
GOALS: To determine patient preference for the Barrett esophagus (BE) screening techniques. BACKGROUND: Sedated esophagogastroduodenoscopy (sEGD) and unsedated transnasal endoscopy (uTNE) are both potential techniques for BE screening. However, systematic assessment of patient preference for these 2 techniques is lacking. As part of a comparative effectiveness randomized trial of BE screening modalities, we measured short-term patient preferences for the following approaches: in-clinic uTNE (huTNE), mobile-based uTNE (muTNE), and sEGD using a novel assessment instrument...
January 23, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29361878/quality-of-endoscopic-surveillance-of-barrett-s-esophagus
#19
Jes Sefland Vogt, Anders Christian Larsen, Thorbjørn Sommer, Per Ejstrud
OBJECTIVES: The aim of this study was to evaluate adherence to Barrett's esophagus (BE) surveillance guidelines in Denmark. METHODS: The Danish Pathology Registry was used to identify 3692 patients. A total of 300 patients were included by drawing a simple random sample. Description of the BE segment, biopsy protocol, communication with the pathologist and planned follow-up endoscopy, was evaluated. RESULTS: Thirty-one patients were excluded due to missing reports and 83 patients (28%) due to no endoscopic evidence of BE...
January 23, 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29356784/gastroesophageal-reflux-frequency-severity-age-of-onset-family-history-and-acid-suppressive-therapy-predict-barrett-esophagus-in-a-large-population
#20
Omar Bakr, Wei Zhao, Douglas Corley
GOALS: To identify risk factors associated with Barrett esophagus (BE) for potential improved surveillance and risk reduction. BACKGROUND: Gastroesophageal reflux disease (GERD) is a known risk factor for esophageal adenocarcinoma, but the ability of GERD symptom frequency and severity to predict presence of its putative precursor lesion, BE, is less well-defined in large, community-based populations. STUDY: We conducted a case-control study within the Kaiser Permanente Northern California population...
January 19, 2018: Journal of Clinical Gastroenterology
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