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Stefan lang

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https://www.readbyqxmd.com/read/27889318/neurogenic-radial-glia-like-cells-in-meninges-migrate-and-differentiate-into-functionally-integrated-neurons-in-the-neonatal-cortex
#1
Francesco Bifari, Ilaria Decimo, Annachiara Pino, Enric Llorens-Bobadilla, Sheng Zhao, Christian Lange, Gabriella Panuccio, Bram Boeckx, Bernard Thienpont, Stefan Vinckier, Sabine Wyns, Ann Bouché, Diether Lambrechts, Michele Giugliano, Mieke Dewerchin, Ana Martin-Villalba, Peter Carmeliet
Whether new neurons are added in the postnatal cerebral cortex is still debated. Here, we report that the meninges of perinatal mice contain a population of neurogenic progenitors formed during embryonic development that migrate to the caudal cortex and differentiate into Satb2(+) neurons in cortical layers II-IV. The resulting neurons are electrically functional and integrated into local microcircuits. Single-cell RNA sequencing identified meningeal cells with distinct transcriptome signatures characteristic of (1) neurogenic radial glia-like cells (resembling neural stem cells in the SVZ), (2) neuronal cells, and (3) a cell type with an intermediate phenotype, possibly representing radial glia-like meningeal cells differentiating to neuronal cells...
November 17, 2016: Cell Stem Cell
https://www.readbyqxmd.com/read/27853298/structured-plant-metabolomics-for-the-simultaneous-exploration-of-multiple-factors
#2
Nikolay Vasilev, Julien Boccard, Gerhard Lang, Ulrike Grömping, Rainer Fischer, Simon Goepfert, Serge Rudaz, Stefan Schillberg
Multiple factors act simultaneously on plants to establish complex interaction networks involving nutrients, elicitors and metabolites. Metabolomics offers a better understanding of complex biological systems, but evaluating the simultaneous impact of different parameters on metabolic pathways that have many components is a challenging task. We therefore developed a novel approach that combines experimental design, untargeted metabolic profiling based on multiple chromatography systems and ionization modes, and multiblock data analysis, facilitating the systematic analysis of metabolic changes in plants caused by different factors acting at the same time...
November 17, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27822599/prehospital-and-intra-hospital-time-delays-in-posterior-circulation-stroke-results-from-the-austrian-stroke-unit-registry
#3
Peter Sommer, Leonhard Seyfang, Alexandra Posekany, Julia Ferrari, Wilfried Lang, Elisabeth Fertl, Wolfgang Serles, Thomas Töll, Stefan Kiechl, Stefan Greisenegger
Therapeutic effect of recombinant tissue-plasminogen activator (rt-PA) is time dependent. There is limited evidence whether localization of stroke within the posterior circulation (PCS) is associated with a treatment delay. We aimed to analyze within a nationwide multicenter cohort whether duration of pre- and intra-hospital patient management differs between patients with PCS and anterior circulation strokes (ACS). We studied onset-to-door-times (ODT) and door-to-needle-times (DNT) of all patients with acute ischemic stroke (IS) enrolled in the Austrian Stroke Unit Registry according to infarct localization...
November 7, 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27822028/effect-of-endurance-versus-resistance-training-on-quadriceps-muscle-dysfunction-in-copd-a-pilot-study
#4
Ulrik Winning Iepsen, Gregers Druedal Wibe Munch, Mette Rugbjerg, Anders Rasmussen Rinnov, Morten Zacho, Stefan Peter Mortensen, Niels H Secher, Thomas Ringbaek, Bente Klarlund Pedersen, Ylva Hellsten, Peter Lange, Pia Thaning
INTRODUCTION: Exercise is an important countermeasure to limb muscle dysfunction in COPD. The two major training modalities in COPD rehabilitation, endurance training (ET) and resistance training (RT), may both be efficient in improving muscle strength, exercise capacity, and health-related quality of life, but the effects on quadriceps muscle characteristics have not been thoroughly described. METHODS: Thirty COPD patients (forced expiratory volume in 1 second: 56% of predicted, standard deviation [SD] 14) were randomized to 8 weeks of ET or RT...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27814907/heterogeneity-of-therapeutic-effects
#5
EDITORIAL
Hans J Trampisch, Henrik Rudolf, Stefan Lange
No abstract text is available yet for this article.
October 27, 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27798774/detection-of-transrenal-dna-for-the-diagnosis-of-pulmonary-tuberculosis-and-treatment-monitoring
#6
Ines Labugger, Jan Heyckendorf, Stefan Dees, Emilia Häussinger, Christian Herzmann, Thomas A Kohl, Elvira Richter, Eric Rivera-Milla, Christoph Lange
PURPOSE: Molecular diagnostics of patients with MTB tuberculosis from urine samples. METHODS: We developed a new molecular assay based on the detection of M. tuberculosis-specific transrenal DNA (trDNA) and tested it for the diagnosis of active tuberculosis at the initiation of anti-tuberculosis therapy and during treatment follow-up. RESULTS: The overall sensitivity of trDNA was 96 and 100% when smear-microscopy and trDNA was combined. In a subset of TB treatment naïve patients (n = 11) sensitivity and specificity of trDNA was 64 and 100%, respectively...
October 31, 2016: Infection
https://www.readbyqxmd.com/read/27792258/flex-robotic-system-in-transoral-robotic-surgery-the-first-40-patients
#7
Stefan Mattheis, Pia Hasskamp, Laura Holtmann, Christina Schäfer, Urban Geisthoff, Nina Dominas, Stephan Lang
BACKGROUND: The Flex Robotic System is a new robotic device specifically developed for transoral robotic surgery (TORS). METHODS: We performed a prospective clinical study, assessing the safety and efficacy of the Medrobotics Flex Robotic System. A total of 40 patients required a surgical procedure for benign lesions (n = 30) or T1 and T2 carcinomas (n = 10). Access and visualization of different anatomic subsites were individually graded by the surgeon. Setup times, access and visualization times, surgical results, as well as adverse events were documented intraoperatively...
October 28, 2016: Head & Neck
https://www.readbyqxmd.com/read/27783427/a-european-multicenter-study-evaluating-the-flex-robotic-system-in-transoral-robotic-surgery
#8
Stephan Lang, Stefan Mattheis, Pia Hasskamp, Georges Lawson, Christian Güldner, Magis Mandapathil, Patrick Schuler, Thomas Hoffmann, Marc Scheithauer, Marc Remacle
OBJECTIVES/HYPOTHESIS: To evaluate the application of the Flex Robotic System in transoral robotic surgery (TORS). STUDY DESIGN: Multicenter, prospective, open-label, single-armed clinical study. METHODS: A prospective clinical follow-up multicenter study was performed from July 2014 to October 2015 assessing the safety and efficacy of the Medrobotics Flex Robotic System for access and visualization of the oropharynx, hypopharynx, and larynx as well as for resection of benign and malignant lesions...
October 26, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27761652/stigmatization-of-psychiatric-symptoms-and-psychiatric-service-use-a-vignette-based-representative-population-survey
#9
Julia F Sowislo, Claudia Lange, Sebastian Euler, Henning Hachtel, Marc Walter, Stefan Borgwardt, Undine E Lang, Christian G Huber
Background There is evidence for two different types and/or sources of mental illness stigma, namely the display of psychiatric symptoms and the use of psychiatric service institutions. However, no current study has compared the two. Furthermore, gaps exist in our knowledge of both types of stigma. Little is known about the perceived stigma of specific psychiatric service treatment environments, for instance forensic settings. In addition, systematic research on stigma attached to symptoms of personality disorders in the general population is scarce, and for borderline personality disorder, nonexistent...
October 19, 2016: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/27759860/value-of-optical-coherence-tomography-angiography-imaging-in-diagnosis-and-treatment-of-hemangioblastomas-in-von-hippel-lindau-disease
#10
Stefan J Lang, Bertan Cakir, Charlotte Evers, Franziska Ludwig, Clemens A K Lange, Hansjürgen T Agostini
BACKGROUND AND OBJECTIVE: The introduction of optical coherence tomography angiography (OCTA) provides new insights into the retinal vasculature. The aim of this study was to explore the value of OCTA in imaging retinal hemangioblastomas and monitoring laser treatment in patients with von Hippel-Lindau (VHL) disease. PATIENTS AND METHODS: Ten eyes of 10 patients with VHL disease were included in this retrospective case series. All patients underwent complete ophthalmological work-up including OCTA for retinal and optic nerve head hemangioblastoma...
October 1, 2016: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/27738647/alterations-in-the-hippocampus-and-thalamus-in-individuals-at-high-risk-for-psychosis
#11
Fabienne Harrisberger, Roman Buechler, Renata Smieskova, Claudia Lenz, Anna Walter, Laura Egloff, Kerstin Bendfeldt, Andor E Simon, Diana Wotruba, Anastasia Theodoridou, Wulf Rössler, Anita Riecher-Rössler, Undine E Lang, Karsten Heekeren, Stefan Borgwardt
Reduction in hippocampal volume is a hallmark of schizophrenia and already present in the clinical high-risk state. Nevertheless, other subcortical structures, such as the thalamus, amygdala and pallidum can differentiate schizophrenia patients from controls. We studied the role of hippocampal and subcortical structures in clinical high-risk individuals from two cohorts. High-resolution T1-weighted structural MRI brain scans of a total of 91 clinical high-risk individuals and 64 healthy controls were collected in two centers...
2016: NPJ Schizophrenia
https://www.readbyqxmd.com/read/27733301/experimentally-induced-psychosocial-stress-in-schizophrenia-spectrum-disorders-a-systematic-review
#12
Claudia Lange, Lorenz Deutschenbaur, Stefan Borgwardt, Undine E Lang, Marc Walter, Christian G Huber
BACKGROUND: There is evidence that exposure to social stress plays a crucial role in the onset and relapse of schizophrenia; however, the reaction of patients with schizophrenia spectrum disorder (SSD) to experimentally induced social stress is not yet fully understood. METHOD: Original research published between January 1993 and August 2015 was included in this systematic literature research. Social stress paradigms, reporting subjective responses to stress measures, plasma or saliva cortisol, or heart rate (HR) in patients with SSD were included...
October 9, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27732920/neurologist-adherence-to-clinical-practice-guidelines-and-costs-in-patients-with-newly-diagnosed-and-chronic-epilepsy-in-germany
#13
Adam Strzelczyk, Arnfin Bergmann, Valeria Biermann, Stefan Braune, Lienhard Dieterle, Bernhard Forth, Lena-Marie Kortland, Michael Lang, Thomas Peckmann, Oliver Schöffski, Karl-Otto Sigel, Felix Rosenow
PURPOSE: The aim of this study was to evaluate physician adherence to the German Neurological Society guidelines of 2008 regarding initial monotherapy and to determine the cost-of-illness in epilepsy. METHODS: This was an observational cohort study using health data routinely collected at 55 outpatient neurology practices throughout Germany (NeuroTransData network). Data on socioeconomic status, course of epilepsy, anticonvulsive treatment, and direct and indirect costs were recorded using practice software-based questionnaires...
October 9, 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/27663567/poor-prognosis-after-second-locoregional-recurrences-in-the-calor-trial
#14
Irene L Wapnir, Shari Gelber, Stewart J Anderson, Eleftherios P Mamounas, André Robidoux, Miguel Martín, Johan W R Nortier, Charles E Geyer, Alexander H G Paterson, István Láng, Karen N Price, Alan S Coates, Richard D Gelber, Priya Rastogi, Meredith M Regan, Norman Wolmark, Stefan Aebi
BACKGROUND: Isolated locoregional recurrences (ILRRs) of breast cancer confer a significant risk for the development of distant metastasis. Management practices and second ILRR events in the Chemotherapy as Adjuvant for LOcally Recurrent breast cancer (CALOR) trial were investigated. METHODS: In this study, 162 patients with ILRR were randomly assigned to receive postoperative chemotherapy or no chemotherapy. Descriptive statistics characterize outcomes according to local therapy and the influence of hormone receptor status on subsequent recurrences...
September 23, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27662018/autotransplant-with-and-without-induction-chemotherapy-in-older-multiple-myeloma-patients-long-term-outcome-of-a-randomized-trial
#15
Christian Straka, Peter Liebisch, Hans Salwender, Burkhard Hennemann, Bernd Metzner, Stefan Knop, Sigrid Adler-Reichel, Christian Gerecke, Hannes Wandt, Martin Bentz, Tim Hendrik Bruemmendorf, Marcus Hentrich, Michael Pfreundschuh, Hans-Heinrich Wolf, Orhan Sezer, Ralf Bargou, Wolfram Jung, Lorenz Trümper, Bernd Hertenstein, Else Heidemann, Helga Bernhard, Nicola Lang, Norbert Frickhofen, Holger Hebart, Ralf Schmidmaier, Andreas Sandermann, Tobias Dechow, Albrecht Reichle, Brigitte Schnabel, Kerstin Schäfer-Eckart, Christian Langer, Martin Gramatzki, Axel Hinke, Bertold Emmerich, Hermann Einsele
Autologous transplantation is controversial for older patients with multiple myeloma. The role of age-adjusted high-dose melphalan and the impact of induction chemotherapy cycles is still unclear. A total of 434 patients aged 60-70 years were randomly assigned to 4 cycles of standard anthracycline-based induction chemotherapy or no induction. For all patients, double autologous transplantation after melphalan 140 mg/m(2) (MEL140) was planned. The primary end point was progression-free survival. Of 420 eligible patients, 85% received a first transplant and 69% completed double transplantation...
November 2016: Haematologica
https://www.readbyqxmd.com/read/27639627/comparison-of-coronary-computed-tomography-angiography-derived-vs-invasive-fractional-flow-reserve-assessment-meta-analysis-with-subgroup-evaluation-of-intermediate-stenosis
#16
Stefan Baumann, Matthias Renker, Svetlana Hetjens, Stephen R Fuller, Tobias Becher, Dirk Loßnitzer, Ralf Lehmann, Ibrahim Akin, Martin Borggrefe, Siegfried Lang, Julian L Wichmann, U Joseph Schoepf
RATIONALE AND OBJECTIVES: Invasive coronary angiography (ICA) with fractional flow reserve (FFR) assessment is the reference standard for the detection of hemodynamically relevant coronary lesions. We have investigated whether coronary computed tomography angiography (cCTA)-derived FFR (fractional flow reserve from coronary computed tomographic angiography [CT-FFR]) measurement improves diagnostic accuracy over cCTA. METHODS AND RESULTS: A literature search was performed for studies comparing invasive FFR, cCTA, and CT-FFR...
September 14, 2016: Academic Radiology
https://www.readbyqxmd.com/read/27634543/synthesis-of-ceramides-ns-and-np-with-perdeuterated-and-specifically-%C3%AF-deuterated-n-acyl-residues
#17
Stefan Sonnenberger, Stefan Lange, Andreas Langner, Reinhard H H Neubert, Bodo Dobner
The synthesis of 12 deuterated ceramides with either a deuteration at the last carbon atom of the amide bound fatty acid or a perdeuterated fatty acid chain is described. The ceramides were prepared starting from sphingosine or phytosphingosine and ω deuterated or perdeuterated fatty acids with PyBOP® as activating agent in high yields. For the synthesis of the specifically deuterated fatty acids, dicarboxylic acids were transformed into ω deuterated alkyl bromide, which was chain elongated with blocked ω bromo alcohols by copper catalyzed Grignard coupling...
October 2016: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/27608630/erratum-to-an-ancient-genome-duplication-contributed-to-the-abundance-of-metabolic-genes-in-the-moss-physcomitrella-patens
#18
Stefan A Rensing, Julia Ick, Jeffrey A Fawcett, Daniel Lang, Andreas Zimmer, Yves Van de Peer, Ralf Reski
No abstract text is available yet for this article.
2016: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/27607432/-about-the-reduction-of-compulsory-measures-by-an-open-door-policy
#19
Undine E Lang, Marc Walter, Stefan Borgwardt, Andreas Heinz
No abstract text is available yet for this article.
September 2016: Psychiatrische Praxis
https://www.readbyqxmd.com/read/27596988/food-induced-changes-of-lipids-in-rat-neuronal-tissue-visualized-by-tof-sims-imaging
#20
Masoumeh Dowlatshahi Pour, Eva Jennische, Stefan Lange, Andrew G Ewing, Per Malmberg
Time of flight secondary ion mass spectrometry (ToF-SIMS) was used to image the lipid localization in brain tissue sections from rats fed specially processed cereals (SPC). An IonTof 5 instrument equipped with a Bi cluster ion gun was used to analyze the tissue sections. Data from 15 brain samples from control and cereal-fed rats were recorded and exported to principal components analysis (PCA). The data clearly show changes of certain lipids in the brain following cereal feeding. PCA score plots show a good separation in lipid distribution between the control and the SPC-fed group...
2016: Scientific Reports
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