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Stefan lang

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https://www.readbyqxmd.com/read/29780173/land-use-in-mountain-grasslands-alters-drought-response-and-recovery-of-carbon-allocation-and-plant-microbial-interactions
#1
Stefan Karlowsky, Angela Augusti, Johannes Ingrisch, Roland Hasibeder, Markus Lange, Sandra Lavorel, Michael Bahn, Gerd Gleixner
Mountain grasslands have recently been exposed to substantial changes in land use and climate and in the near future will likely face an increased frequency of extreme droughts. To date, how the drought responses of carbon (C) allocation, a key process in the C cycle, are affected by land-use changes in mountain grassland is not known.We performed an experimental summer drought on an abandoned grassland and a traditionally managed hay meadow and traced the fate of recent assimilates through the plant-soil continuum...
May 2018: Journal of Ecology
https://www.readbyqxmd.com/read/29769055/one-visceral-artery-may-be-enough-successful-pancreatectomy-in-a-patient-with-total-occlusion-of-the-celiac-and-superior-mesenteric-arteries
#2
Evangelos Tagkalos, Florian Jungmann, Hauke Lang, Stefan Heinrich
BACKGROUND: The anatomic variations of the visceral arteries are not uncommon. The liver arterial blood supply shows 50% variability between humans, with the most common anatomy being one hepatic artery arising from the celiac trunk and one pancreatico-duodenal arcade between the celiac trunk and the superior mesenteric artery. Occlusion of one artery are mostly asymptomatic but may become clinically relevant when surgery of the liver, bile duct or the pancreas is required. If these pathologies are not reversible, an oncologic pancreatic head resection cannot be performed...
May 16, 2018: BMC Surgery
https://www.readbyqxmd.com/read/29768641/-the-role-of-elective-neck-dissection-during-salvage-laryngectomy-a-retrospective-analysis
#3
Timon Hussain, Oliver Kanaan, Benedikt Höing, Nina Dominas, Stephan Lang, Stefan Mattheis
Elective neck dissection of the N0-neck is routinely performed during salvage laryngectomy (SLE) for recurrent cancer of the larynx or hypopharynx. The therapeutic benefit of additional neck dissection must be weighed against the risk of increased morbidity. In this retrospective analysis, we assessed oncologic parameters of patients who underwent SLE with concurrent bilateral neck dissection for recurrent laryngeal or hypopharyngeal cancer. We compared these data with patients who underwent primary laryngectomy (LE) with bilateral neck dissection for laryngeal and hypopharyngeal cancer...
May 16, 2018: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/29750473/dermatologische-rezepturen-in-deutschland-relevanz-f%C3%A3-r-die-versorgung
#4
Petra Staubach, Stefan Salzmann, Adriane Peveling-Oberhag, Veronika Weyer, Sebastian Zimmer, Gabriele Gradl, Berenice M Lang
No abstract text is available yet for this article.
May 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29750454/extemporaneous-formulations-in-germany-relevance-for-everyday-clinical-practice
#5
Petra Staubach, Stefan Salzmann, Adriane Peveling-Oberhag, Veronika Weyer, Sebastian Zimmer, Gabriele Gradl, Berenice M Lang
BACKGROUND: Extemporaneous formulations broaden the spectrum of therapeutic options for topical treatment in particular and thus improve patient care. The latest amendment to the Regulation on the Operation of Pharmacies issued in 2012 brought about changes in prescribing and manufacturing practices. The aim of the present study was to assess the relevance of extemporaneous formulations in everyday clinical practice. METHODS: We used data from the German Institute for Drug Use Evaluation (DAPI) to analyze the prescribing practice for compounded preparations in Germany between the fourth quarter of 2011 and the third quarter of 2014...
May 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29733990/flat-panel-detector-computed-tomography-fdct-guided-placement-of-external-ventricular-drains-using-the-brainlab-%C3%A2-headband-and-the-precalibrated-disposable-stylet-instrument-a-cadaveric-feasibility-study
#6
Julian Feulner, Stefan Lang, Thomas Buder, Tobias Struffert, Michael Buchfelder, Sebastian Brandner
BACKGROUND: The standard freehand method for the insertion of external ventricular drains (EVD) is associated with high rates of incorrect placement. The use of neuronavigation has been shown to reduce the rates of inaccurately positioned EVDs. We present a novel neuronavigation-based approach for EVD placement using flat panel detector computed tomography (FDCT) imaging. METHODS: Four cadaveric heads were used for neuronavigated placement of EVDs using the BrainLAB® reference Headband in combination with laser surface registration and the precalibrated disposable Stylet...
May 4, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29727331/10th-anniversary-of-alpps-lessons-learned-and-quo-vadis
#7
Hauke Lang, Eduardo de Santibañes, Hans J Schlitt, Massimo Malagó, Thomas van Gulik, Marcel A Machado, Elio Jovine, Stefan Heinrich, Giuseppe Maria Ettorre, Albert Chan, Roberto Hernandez-Alejandro, Ricardo Robles Campos, Per Sandström, Michael Linecker, Pierre-Alain Clavien
OBJECTIVE: Associating Liver Partition and Portal vein ligation for Staged hepatectomy (ALPPS) has been tested in various indications and clinical scenarios, leading to steady improvements in safety. This report presents the current status of ALPPS. SUMMARY BACKGROUND DATA: ALPPS offers improved resectability, but drawbacks are regularly pointed out regarding safety and oncologic benefits. METHODS: During the 12th biennial congress of the European African-Hepato-Pancreato-Biliary Association (Mainz, Germany, May 23-26, 2017) an expert meeting "10th anniversary of ALPP" was held to discuss indications, management, mechanisms of regeneration, as well as pitfalls of this novel technique...
May 1, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29724897/targeting-hsp90-dimerization-via-the-c-terminus-is-effective-in-imatinib-resistant-cml-and-lacks-heat-shock-response
#8
Sanil Bhatia, Daniela Diedrich, Benedikt Frieg, Heinz Ahlert, Stefan Stein, Bertan Bopp, Franziska Lang, Tao Zang, Tobias Kröger, Thomas Ernst, Gesine Kögler, Andreas Krieg, Steffen Lüdeke, Hana Kunkel, Ana J Rodrigues Moita, Matthias U Kassack, Viktoria Marquardt, Friederike V Opitz, Marina Oldenburg, Marc Remke, Florian Babor, Manuel Grez, Andreas Hochhaus, Arndt Borkhardt, Georg Groth, Luitgard Nagel-Steger, Joachim Jose, Thomas Kurz, Holger Gohlke, Finn K Hansen, Julia Hauer
Heat shock protein 90 (HSP90) stabilizes many client proteins including BCR-ABL1 oncoprotein. BCR-ABL1 is the hallmark of CML in which treatment-free remission (TFR) is limited with clinical and economic consequences. Thus, there is an urgent need for novel therapeutics, which synergize with current treatment approaches. Several inhibitors targeting the N-terminal domain (NTD) of HSP90 are under investigation; however, side effects such as induction of heat shock response (HSR) and toxicity have so far precluded their FDA approval...
May 3, 2018: Blood
https://www.readbyqxmd.com/read/29723064/cell-free-hemoglobin-in-the-fetoplacental-circulation-a-novel-cause-of-fetal-growth-restriction
#9
Adam Brook, Annie Hoaksey, Rekha Gurung, Edward E C Yoong, Rosanna Sneyd, Georgia C Baynes, Helen Bischof, Sarah Jones, Lucy E Higgins, Carolyn Jones, Susan L Greenwood, Rebecca L Jones, Magnus Gram, Ingrid Lang, Gernot Desoye, Jenny Myers, Henning Schneider, Stefan R Hansson, Ian P Crocker, Paul Brownbill
Cell free hemoglobin impairs vascular function and blood flow in adult cardiovascular disease. In this study, we investigated the hypothesis that free fetal hemoglobin (fHbF) compromises vascular integrity and function in the fetoplacental circulation, contributing to the increased vascular resistance associated with fetal growth restriction (FGR). Women with normal and FGR pregnancies were recruited and their placentas collected freshly postpartum. FGR fetal capillaries showed evidence of erythrocyte vascular packing and extravasation...
May 3, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29722290/feasibility-of-polymer-gel-based-measurements-of-radiation-isocenter-accuracy-in-magnetic-fields
#10
Stefan Dorsch, Philipp Mann, Clemens Lang, Peter Häring, Armin Runz, Christian P Karger
For conventional irradiation devices, the radiation isocenter accuracy is determined by star shot measurements on films. In magnetic resonance (MR)-guided radiotherapy devices, the results of this test may be altered by the magnetic field and the need to align radiation and imaging isocenter may require a modification of measurement procedures. Polymer dosimetry gels (PG) may offer a way to perform both, radiation and imaging isocenter test, however, it has to be shown first that PG reveals comparable results as the conventionally applied films...
May 3, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29720453/playing-hide-and-seek-with-factor-h-game-theoretical-analysis-of-a-single-nucleotide-polymorphism
#11
Sabine Hummert, Christina Glock, Stefan N Lang, Christian Hummert, Christine Skerka, Peter F Zipfel, Sebastian Germerodt, Stefan Schuster
As a part of the complement system, factor H regulates phagocytosis and helps differentiate between a body's own and foreign cells. Owing to mimicry efforts, some pathogenic microorganisms such as Candida albicans are able to bind factor H on their cell surfaces and, thus, become similar to host cells. This implies that the decision between self and foreign is not clear-cut, which leads to a classification problem for the immune system. Here, two different alleles determining the binding affinity of factor H are relevant...
May 2018: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/29710118/disorganized-gyrification-network-properties-during-the-transition-to-psychosis
#12
Tushar Das, Stefan Borgwardt, Daniel J Hauke, Fabienne Harrisberger, Undine E Lang, Anita Riecher-Rössler, Lena Palaniyappan, André Schmidt
Importance: There is urgent need to improve the limited prognostic accuracy of clinical instruments to predict psychosis onset in individuals at clinical high risk (CHR) for psychosis. As yet, no reliable biological marker has been established to delineate CHR individuals who will develop psychosis from those who will not. Objectives: To investigate abnormalities in a graph-based gyrification connectome in the early stages of psychosis and to test the accuracy of this systems-based approach to predict a transition to psychosis among CHR individuals...
April 25, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29706960/macrophage-derived-extracellular-vesicles-induce-long-lasting-immunity-against-hepatitis-c-virus-which-is-blunted-by-polyunsaturated-fatty-acids
#13
Chengcong Cai, Benjamin Koch, Kenichi Morikawa, Goki Suda, Naoya Sakamoto, Sabrina Rueschenbaum, Sami Akhras, Julia Dietz, Eberhard Hildt, Stefan Zeuzem, Christoph Welsch, Christian M Lange
Extracellular vesicles (EVs) are increasingly recognized as important mediators of intercellular communication. In this study, we aimed to further characterize the role of macrophage-derived EVs in immune responses against hepatitis C virus (HCV) and the potential of polyunsaturated fatty acids (PUFAs) to modulate this modality of innate immunity. To this end, EVs were isolated from interferon-stimulated macrophage cultures or from serum of patients with acute or chronic hepatitis C. EVs were characterized by electron microscopy, flow cytometry, RNA-sequencing, and Western blot analysis...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29706905/positive-effects-of-an-anti-aggression-and-de-escalation-training-on-ward-atmosphere-and-subjective-safety-may-depend-on-previous-training-experience
#14
Daniela Fröhlich, Franziska Rabenschlag, Susanne Schoppmann, Stefan Borgwardt, Undine E Lang, Christian G Huber
Anti-aggression and de-escalation (ADE) trainings of health-care professionals working on psychiatric inpatient wards have been shown to increase staff knowledge and confidence, which could be connected with higher subjective safety. Additionally, a potential reduction of aggressive incidents could improve ward atmosphere. Thus, the current study aimed to investigate the effects of ADE training on ward atmosphere and subjective safety. In 2015, an ADE training was established at the Psychiatric University Clinics (UPK), University of Basel...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29696364/differential-somatostatin-cxcr4-chemokine-and-endothelin-a-receptor-expression-in-who-grade-i-iv-astrocytic-brain-tumors
#15
Franziska Lange, Daniel Kaemmerer, Julianne Behnke-Mursch, Wolfgang Brück, Stefan Schulz, Amelie Lupp
PURPOSE: Glioblastomas represent the most common primary malignant tumor of the nervous system and the most frequent type of astrocytic tumors. Despite improved therapeutic options, prognosis has remained exceptionally poor over the last two decades. Therefore, new treatment approaches are urgently needed. An overexpression of somatostatin (SST) as well as chemokine CXCR4 and endothelin A (ETA) receptors has been shown for many types of cancer. Respective expression data for astrocytic brain tumors, however, are scarce and contradictory...
April 25, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29681058/the-physcomitrella-patens-gene-atlas-project-large-scale-rna-seq-based-expression-data
#16
Pierre-François Perroud, Fabian B Haas, Manuel Hiss, Kristian K Ullrich, Alessandro Alboresi, Mojgan Amirebrahimi, Kerrie Barry, Roberto Bassi, Sandrine Bonhomme, Haodong Chen, Juliet Coates, Tomomichi Fujita, Anouchka Guyon-Debast, Daniel Lang, Junyan Lin, Anna Lipzen, Fabien Nogué, Melvin J Oliver, Inés Ponce de León, Ralph S Quatrano, Catherine Rameau, Bernd Reiss, Ralf Reski, Mariana Ricca, Younousse Saidi, Ning Sun, Peter Szövényi, Avinash Sreedasyam, Jane Grimwood, Gary Stacey, Jeremy Schmutz, Stefan A Rensing
High throughput RNA sequencing (RNA-seq) has recently become the method of choice to define and analyse transcriptomes. For the model moss Physcomitrella patens, although this method has been used to help the analysis of specific perturbations, no overall reference dataset has been established yet. In the framework of its Gene Atlas project, the Joint Genome Institute selected P. patens as a flagship genome, opening the way to generate the first comprehensive transcriptome dataset for this moss. The first round of sequencing described here is composed of 99 independent libraries spanning 34 different developmental stages and conditions...
April 22, 2018: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29678776/comparison-of-the-3d-structures-of-mouse-and-human-%C3%AE-synuclein-fibrils-by-solid-state-nmr-and-stem
#17
Songhwan Hwang, Pascal Fricke, Maximilian Zinke, Karin Giller, Joseph S Wall, Dietmar Riedel, Stefan Becker, Adam Lange
Intra-neuronal aggregation of α-synuclein into fibrils is the molecular basis for α -synucleinopathies, such as Parkinson's disease. The atomic structure of human α -synuclein (hAS) fibrils was recently determined by Tuttle et al. using solid-state NMR (ssNMR). The previous study found that hAS fibrils are composed of a single protofilament. Here, we have investigated the structure of mouse α -synuclein (mAS) fibrils by STEM and isotope-dilution ssNMR experiments. We found that in contrast to hAS, mAS fibrils consist of two or even three protofilaments which are connected by rather weak interactions in between them...
April 17, 2018: Journal of Structural Biology
https://www.readbyqxmd.com/read/29628141/pseudouridylation-of-trna-derived-fragments-steers-translational-control-in-stem-cells
#18
Nicola Guzzi, Maciej Cieśla, Phuong Cao Thi Ngoc, Stefan Lang, Sonali Arora, Marios Dimitriou, Kristyna Pimková, Mikael N E Sommarin, Roberto Munita, Michal Lubas, Yiting Lim, Kazuki Okuyama, Shamit Soneji, Göran Karlsson, Jenny Hansson, Göran Jönsson, Anders H Lund, Mikael Sigvardsson, Eva Hellström-Lindberg, Andrew C Hsieh, Cristian Bellodi
Pseudouridylation (Ψ) is the most abundant and widespread type of RNA epigenetic modification in living organisms; however, the biological role of Ψ remains poorly understood. Here, we show that a Ψ-driven posttranscriptional program steers translation control to impact stem cell commitment during early embryogenesis. Mechanistically, the Ψ "writer" PUS7 modifies and activates a novel network of tRNA-derived small fragments (tRFs) targeting the translation initiation complex. PUS7 inactivation in embryonic stem cells impairs tRF-mediated translation regulation, leading to increased protein biosynthesis and defective germ layer specification...
April 4, 2018: Cell
https://www.readbyqxmd.com/read/29625176/high-doses-of-antisecretory-factor-stop-diarrhea-fast-without-recurrence-for-six-weeks-post-treatment
#19
Shakila Zaman, Khalida Aamir, Lars Å Hanson, Stefan Lange
BACKGROUND: Diarrheal illnesses in young children cause morbidity and preventable deaths in developing countries. We evaluated two high doses of Salovum® [Antisecretory Factor] to treat diarrhea in young children and followed for recurrence 6 weeks post treatment. METHODS: Forty children, 6-24 months old, admitted with acute diarrhea, to the Outpatient Department of Children's Hospital in Lahore, Pakistan were selected. The patients were randomly allocated to either Group A given 2 sachets, or to Group B, given 4 sachets...
April 3, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29605160/sexually-dimorphic-subcortical-brain-volumes-in-emerging-psychosis
#20
Laura Egloff, Claudia Lenz, Erich Studerus, Fabienne Harrisberger, Renata Smieskova, André Schmidt, Christian Huber, Andor Simon, Undine E Lang, Anita Riecher-Rössler, Stefan Borgwardt
BACKGROUND: In schizophrenic psychoses, the normal sexual dimorphism of the brain has been shown to be disrupted or even reversed. Little is known, however, at what time point in emerging psychosis this occurs. We have therefore examined, if these alterations are already present in the at-risk mental state (ARMS) for psychosis and in first episode psychosis (FEP) patients. METHODS: Data from 65 ARMS (48 (73.8%) male; age=25.1±6.32) and 50 FEP (37 (74%) male; age=27±6...
March 28, 2018: Schizophrenia Research
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