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https://www.readbyqxmd.com/read/29913375/versatile-graphene-biosensors-for-enhancing-human-cell-therapy
#1
REVIEW
George M Vlăsceanu, Roxana-Maria Amărandi, Mariana Ioniță, Teddy Tite, Horia Iovu, Luisa Pilan, Jorge S Burns
Technological advances in engineering and cell biology stimulate novel approaches for medical treatment, in particular cell-based therapy. The first cell-based gene therapy against cancer was recently approved by the US Food and Drug Administration. Progress in cancer diagnosis includes a blood test detecting five cancer types. Numerous stem cell phase I/II clinical trials showing safety and efficacy will soon pursue qualifying criteria for advanced therapy medicinal products (ATMP), aspiring to join the first stem-cell therapy approved by the European Medicines Agency...
May 1, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29913324/substance-use-recovery-and-linguistics-the-impact-of-word-choice-on-explicit-and-implicit-bias
#2
Robert D Ashford, Austin M Brown, Brenda Curtis
BACKGROUND: The general public, treatment professionals, and healthcare professionals have been found to exhibit an explicit negative bias towards substance use and individuals with a substance use disorder (SUD). Terms such as "substance abuser" and "opioid addict" have shown to elicit greater negative explicit bias. However, other common terms have yet to be empirically studied. METHODS: 1,288 participants were recruited from ResearchMatch...
June 13, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29913255/chemoprevention-of-leishmaniasis-in-vitro-antiparasitic-activity-of-dibenzalacetone-a-synthetic-curcumin-analog-leads-to-apoptotic-cell-death-in-leishmania-donovani
#3
Indira Singh Chauhan, G SubbaRao, Jai Shankar, Lalit Kumar Singh Chauhan, Govind J Kapadia, Neeloo Singh
Curcumin is the major phenolic compound found in turmeric, a dry powder of rhizomes and roots of the plant, Curcuma longa L., which is widely used as spice and food colorant around the world, and in herbal medicinal practice in Asian countries. The present study reports the leishmanicidal activity of trans-dibenzalacetone (DBA), a synthetic monoketone analog of curcumin, against Leishmania donovani parasites. We for the first time report the antiproliferative effect of a curcumin analog (DBA) on the intracellular amastigotes of L...
June 15, 2018: Parasitology International
https://www.readbyqxmd.com/read/29912920/sensitive-operation-of-enzyme-based-biodevices-by-advanced-signal-processing
#4
Stanislav Mazurenko, Sarka Bidmanova, Marketa Kotlanova, Jiri Damborsky, Zbynek Prokop
Analytical devices that combine sensitive biological component with a physicochemical detector hold a great potential for various applications, e.g., environmental monitoring, food analysis or medical diagnostics. Continuous efforts to develop inexpensive sensitive biodevices for detecting target substances typically focus on the design of biorecognition elements and their physical implementation, while the methods for processing signals generated by such devices have received far less attention. Here, we present fundamental considerations related to signal processing in biosensor design and investigate how undemanding signal treatment facilitates calibration and operation of enzyme-based biodevices...
2018: PloS One
https://www.readbyqxmd.com/read/29912642/investigation-of-the-potential-for-a-simplified-exposure-tool-in-medical-nutrition-setim-to-minimise-exposures-to-sweeteners-in-young-patients-aged-1-3-years-with-pku-and-cmpa
#5
Aaron J O'Sullivan, Cian O'Mahony, Leo Meunier, Nik Loveridge, Aideen I McKevitt
Children with Phenylketonuria (PKU) and severe cow's milk protein allergy (CMPA) consume prescribed, specially formulated, foods for special medical purposes (FSMPs) in addition to having restricted intake of normal foods. These vulnerable patients are exposed to artificial sweeteners from the consumption of a combination of both free and prescribed foods. Young patients with PKU and CMPA aged from 1-3 years have a higher risk of exceeding the acceptable daily intake (ADI) for sweeteners than age-matched healthy children...
June 18, 2018: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/29912258/-the-way-of-the-rubber
#6
Walter Ledermann
Investigations first by Markham, and then by Spruce, performed in the middle of multiple risks, in the deep of dense jungle, through the wild rivers and facing up natives many times hostile, brought the knowledge of the life cycle of Hevea brasiliensis, the rubber's tree, necessary for take its seeds to Asia, its adaptation to this continent and its culture at industrial level. Undoubtedly these men were the heroes of this history, but they were wise, modest and quite people, so the glory was for an entrepreneur decided and of scare scruples, like Wickham...
April 2018: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/29912175/design-and-parameter-study-of-integrated-microfluidic-platform-for-ctc-isolation-and-enquiry-a-numerical-approach
#7
Amir Shamloo, Saba Ahmad, Maede Momeni
Being the second cause of mortality across the globe, there is now a persistent effort to establish new cancer medication and therapies. Any accomplishment in treating cancers entails the existence of accurate identification systems empowering the early diagnosis. Recent studies indicate CTCs’ potential in cancer prognosis as well as therapy monitoring. The chief shortcoming with CTCs is that they are exceedingly rare cells in their clinically relevant concentration. Here, we simulated a microfluidic construct devised for immunomagnetic separation of the particles of interest from the background cells...
June 18, 2018: Biosensors
https://www.readbyqxmd.com/read/29911965/exploring-empathy-in-the-face-of-patient-anonymity-and-professional-challenges-and-barriers
#8
Carina Mendoza
This article defines empathy as the conveyed expression of awareness, understanding, and sensitivity to the experiences, feelings, and emotions of a patient with a medical condition. This article is a reflective short story addressing empathy through the eyes of Maria (a fictitious patient), who is confronted with the challenges of negotiating her first encounter at a medical facility, and through the actions of Dr Jones (a fictitious physician) who, at a critical juncture, fails to engage empathically with her patient donning the ubiquitous hospital gown...
May 30, 2018: Permanente Journal
https://www.readbyqxmd.com/read/29911293/improved-and-adopted-murine-models-to-combat-pulmonary-aspergillosis
#9
REVIEW
Gaspar Banfalvi
The insufficient basic and clinical knowledge about invasive mold infections necessitated to review aspergillosis rodent models. The scope of this review has two major aspects. (1) It briefly summarizes Aspergillus toxicoses, the adverse effects of Aspergillus mycotoxins, the virulence factors of Aspergillus fumigatus, and how mild Aspergillus infections can turn to immunosuppressive diseases, ultimately to lethal invasive pulmonary aspergillosis. (2) The second major aspect of the review deals with earlier and recent murine models of pulmonary aspergillosis...
June 17, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29910769/assessment-of-perceived-attractiveness-usability-and-societal-impact-of-a-multimodal-robotic-assistant-for-aging-patients-with-memory-impairments
#10
Justyna Gerłowska, Urszula Skrobas, Katarzyna Grabowska-Aleksandrowicz, Agnieszka Korchut, Sebastian Szklener, Dorota Szczęśniak-Stańczyk, Dimitrios Tzovaras, Konrad Rejdak
The aim of the present study is to present the results of the assessment of clinical application of the robotic assistant for patients suffering from mild cognitive impairments (MCI) and Alzheimer Disease (AD). The human-robot interaction (HRI) evaluation approach taken within the study is a novelty in the field of social robotics. The proposed assessment of the robotic functionalities are based on end-user perception of attractiveness, usability and potential societal impact of the device. The methods of evaluation applied consist of User Experience Questionnaire (UEQ), AttrakDiff and the societal impact inventory tailored for the project purposes...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29910621/a-new-apatinib-microcrystal-formulation-enhances-the-effect-of-radiofrequency-ablation-treatment-on-hepatocellular-carcinoma
#11
Hui Xie, Shengtao Tian, Haipeng Yu, Xueling Yang, Jia Liu, Huaming Wang, Fan Feng, Zhi Guo
Introduction: Radiofrequency ablation (RFA) is the foremost treatment option for advanced hepatocellular carcinoma (HCC), however, rapid and aggressive recurrence of HCC often occurs after RFA due to epithelial-mesenchymal transition process. Although combination of RFA with sorafenib, a molecular targeted agent, could attenuate the recurrence of HCC, application of this molecular targeted agent poses a heavy medical burden and oral administration of sorafenib also brings severe side effects...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29910602/2-amino-1-3-4-thiadiazole-as-a-potential-scaffold-for-promising-antimicrobial-agents
#12
REVIEW
Georgeta Serban, Oana Stanasel, Eugenia Serban, Sanda Bota
Pathogenic microorganisms are causative agents for different types of serious and even lethal infectious diseases. Despite advancements in medication, bacterial and fungal infections continue to be a growing problem in health care. As more and more bacteria become resistant to antibiotics used in therapy and an increasing number of invasive fungal species become resistant to current antifungal medications, there is considerable interest in the development of new compounds with antimicrobial activity. The compounds containing a heterocyclic ring play an important role among organic compounds with biological activity used as drugs in human and veterinary medicine or as insecticides and pesticides in agriculture...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29910062/mass-spectrometry-in-pathology-vision-for-a-future-workflow
#13
REVIEW
Jörg Kriegsmann, Rita Casadonte, Katharina Kriegsmann, Rémi Longuespée, Mark Kriegsmann
Mass spectrometric (MS) techniques are applied in various areas of medical diagnostics. For the detection of microbiological germs and genetic mutations, MS is a method used in routine. Since MS also allows the analysis of proteins and peptides, it seems an ideal candidate to supplement histopatholological diagnostics. Matrix-assisted laser desorption/ionization time-of-flight Imaging MS links molecular analysis of numerous analytes with morphological information about their spatial distribution in cells or tissues...
May 17, 2018: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29910015/developing-an-opioid-use-disorder-treatment-cascade-a-review-of-quality-measures
#14
Arthur Robin Williams, Edward V Nunes, Adam Bisaga, Harold A Pincus, Kimberly A Johnson, Aimee N Campbell, Remien H Remien, Stephen Crystal, Peter D Friedmann, Frances R Levin, Mark Olfson
BACKGROUND: Despite increasing opioid overdose mortality, problems persist in the availability and quality of treatment for opioid use disorder (OUD). Three FDA-approved medications (methadone, buprenorphine, and naltrexone) have high quality evidence supporting their use, but most individuals with OUD do not receive them and many experience relapse following care episodes. Developing and organizing quality measures under a unified framework such as a Cascade of Care could improve system level practice and treatment outcomes...
August 2018: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/29909969/short-term-fasting-reveals-amino-acid-metabolism-as-a-major-sex-discriminating-factor-in-the-liver
#15
Sara Della Torre, Nico Mitro, Clara Meda, Federica Lolli, Silvia Pedretti, Matteo Barcella, Luisa Ottobrini, Daniel Metzger, Donatella Caruso, Adriana Maggi
Sex impacts on liver physiology with severe consequences for energy metabolism and response to xenobiotic, hepatic, and extra-hepatic diseases. The comprehension of the biology subtending sex-related hepatic differences is therefore very relevant in the medical, pharmacological, and dietary perspective. The extensive application of metabolomics paired to transcriptomics here shows that, in the case of short-term fasting, the decision to maintain lipid synthesis using amino acids (aa) as a source of fuel is the key discriminant for the hepatic metabolism of male and female mice...
June 6, 2018: Cell Metabolism
https://www.readbyqxmd.com/read/29909867/selection-of-and-evidentiary-considerations-for-wearable-devices-and-their-measurements-for-use-in-regulatory-decision-making-recommendations-from-the-epro-consortium
#16
Bill Byrom, Chris Watson, Helen Doll, Stephen Joel Coons, Sonya Eremenco, Rachel Ballinger, Marie Mc Carthy, Mabel Crescioni, Paul O'Donohoe, Cindy Howry
BACKGROUND: Wearable devices offer huge potential to collect rich sources of data to provide insights into the effects of treatment interventions. Despite this, at the time of writing this report, limited regulatory guidance on the use of wearables in clinical trial programs has been published. OBJECTIVES: To present recommendations from the Critical Path Institute's Electronic Patient-Reported Outcome Consortium regarding the selection and evaluation of wearable devices and their measurements for use in regulatory trials and to support labeling claims...
June 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29909860/outcomes-and-associated-factors-in-malpractice-litigation-involving-inferior-vena-cava-filters
#17
REVIEW
Kenny Oh, Anil Hingorani
OBJECTIVE: Placement of inferior vena cava (IVC) filters is a controversial focus of medical malpractice. Clinicians currently have little information to guide them regarding key issues and outcomes in litigation. In this retrospective legal case review, we analyzed the factors associated with malpractice actions involving IVC filters. METHODS: The legal databases LexisNexis and Westlaw were searched from 1967 to 2016 for all published legal cases in the United States involving placement of IVC filters...
July 2018: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/29909836/characterization-of-pl-7-family-alginate-lyases-from-marine-organisms-and-their-applications
#18
Akira Inoue
Alginate, an anionic heteropolysaccharide extracted from natural brown algae, has useful properties for the food, chemical, medical, and agricultural industries. Degradation of alginate by alginate lyase is a key process to produce unsaturated oligoalginate and unsaturated monosaccharide 4-deoxy-l-erythro-5-hexoseulose uronic acid. Alginate lyases belonging to the polysaccharide lyase family 7 have been found in, and isolated from, organisms thriving in various environments. Furthermore, research on their function and structure has also progressed well...
2018: Methods in Enzymology
https://www.readbyqxmd.com/read/29909835/polysaccharide-degrading-enzymes-from-marine-gastropods
#19
Takao Ojima, Mohammad M Rahman, Yuya Kumagai, Ryuji Nishiyama, Joemark Narsico, Akira Inoue
Seaweed polysaccharides have been widely used as viscosifier, gelling agents, and stabilizer in the various application fields, e.g., food, pharmaceutical, nutraceutical, and chemical industries. Applications of seaweed polysaccharides are further expanding to versatile directions, e.g., biofuels, bioactive compounds, and functional materials for medical and basic researches. Production of functional oligo- and monosaccharides by the use of specific enzymes is also expected to improve the value of seaweed polysaccharides...
2018: Methods in Enzymology
https://www.readbyqxmd.com/read/29909524/suitability-and-setup-of-next-generation-sequencing-based-method-for-taxonomic-characterization-of-aquatic-microbial-biofilm
#20
Tomas Bakal, Jiri Janata, Lenka Sabova, Roman Grabic, Vladimir Zlabek, Lucie Najmanova
A robust and widely applicable method for sampling of aquatic microbial biofilm and further sample processing is presented. The method is based on next-generation sequencing of V4-V5 variable regions of 16S rRNA gene and further statistical analysis of sequencing data, which could be useful not only to investigate taxonomic composition of biofilm bacterial consortia but also to assess aquatic ecosystem health. Five artificial materials commonly used for biofilm growth (glass, stainless steel, aluminum, polypropylene, polyethylene) were tested to determine the one giving most robust and reproducible results...
June 16, 2018: Folia Microbiologica
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