keyword
MENU ▼
Read by QxMD icon Read
search

Medical applications

keyword
https://www.readbyqxmd.com/read/29691829/in-situ-cross-linkable-polymer-systems-and-composites-for-osteochondral-regeneration
#1
María Puertas-Bartolomé, Lorena Benito-Garzón, Marta Olmeda-Lozano
Injectable hydrogels have demonstrated being a promising strategy for cartilage and bone tissue engineering applications, owing to their minimal invasive injection procedure, easy incorporation of cells and bioactive molecules, improved contact with the surrounding tissues and ability to match defects with complex irregular shapes, characteristics of osteoarthritic pathology. These unique properties make them highly suitable bioscaffolds for treating defects which are otherwise not easily accessible without and invasive surgical procedure...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29691418/immunosilencing-peptides-by-stereochemical-inversion-and-sequence-reversal-retro-d-peptides
#2
Pol Arranz-Gibert, Sonia Ciudad, Jesús Seco, Jesús García, Ernest Giralt, Meritxell Teixidó
Peptides are experiencing a new era in medical research, finding applications ranging from therapeutics to vaccines. In spite of the promising properties of peptide pharmaceuticals, their development continues to be hindered by three weaknesses intrinsic to their structure, namely protease sensitivity, clearance through the kidneys, and immune system activation. Here we report on two retro-D-peptides (H2 N-hrpyiah-CONH2 and H2 N-pwvpswmpprht-CONH2 ), which are protease-resistant and retain the original BBB shuttle activity of the parent peptide but are much less immunogenic than the parent peptide...
April 24, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29691297/validation-of-a-plasma-based-comprehensive-cancer-genotyping-assay-utilizing-orthogonal-tissue-and-plasma-based-methodologies
#3
Justin I Odegaard, John J Vincent, Stefanie Mortimer, James V Vowles, Bryan C Ulrich, Kimberly C Banks, Stephen R Fairclough, Oliver A Zill, Marcin Sikora, Reza Mokhtari, Diana Abdueva, Rebecca J Nagy, Christine E Lee, Lesli A Kiedrowski, Cloud P Paweletz, Helmy Eltoukhy, Richard B Lanman, Darya I Chudova, AmirAli Talasaz
PURPOSE: Liquid biopsies are powerful tools that enable non-invasive genotyping of advanced solid tumors; however, comprehensive, structured validation studies employing validated orthogonal comparator methods are lacking. EXPERIMENTAL DESIGN: Analytical validation was conducted according to established principles and guidelines. Blood-to-blood clinical validation comprised blinded external comparison to clinical digital droplet PCR across 222 consecutive biomarker-positive clinical samples...
April 24, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29691201/identifying-unmet-treatment-needs-for-patients-with-osteoporotic-fracture-feasibility-study-for-an-electronic-clinical-surveillance-system
#4
Fong-Ci Lin, Chen-Yu Wang, Rung Ji Shang, Fei-Yuan Hsiao, Mei-Shu Lin, Kuan-Yu Hung, Jui Wang, Zhen-Fang Lin, Feipei Lai, Li-Jiuan Shen, Chih-Fen Huang
BACKGROUND: Traditional clinical surveillance relied on the results from clinical trials and observational studies of administrative databases. However, these studies not only required many valuable resources but also faced a very long time lag. OBJECTIVE: This study aimed to illustrate a practical application of the National Taiwan University Hospital Clinical Surveillance System (NCSS) in the identification of patients with an osteoporotic fracture and to provide a high reusability infrastructure for longitudinal clinical data...
April 24, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29691098/improved-patency-after-axillofemoral-bypass-for-aortoiliac-occlusive-disease
#5
Russell H Samson, David P Showalter, Michael R Lepore, Deepak G Nair, Douglas A Dorsay, Ricardo E Morales
OBJECTIVE: Axillofemoral bypasses (AxFBs) have been used since 1962 to treat aortoiliac disease. In the past, reported patency rates (37%-76%) for these extra-anatomic grafts have been inferior to those for anatomic aortic grafting. Reported low survival rates after AxFB (40%-50%) have confirmed that these procedures have been used primarily in patients at high risk for complications from aortofemoral bypass. However, modern medical and anesthesia management, preoperative scanning, donor artery preparation, postoperative graft surveillance, and graft technology may improve outcomes after AxFB, possibly supporting expansion of its use...
April 21, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29691015/gradual-degradation-of-fucoidan-from-fucus-vesiculosus-and-its-effect-on-structure-antioxidant-and-antiproliferative-activities
#6
Eric Lahrsen, Inga Liewert, Susanne Alban
The fucose-containing sulfated polysaccharides (syn. fucoidans) from brown algae exhibit a wide range of bioactivities and are therefore considered promising candidates for health-supporting and medical applications. During the past three decades, research on isolation, molecular characterization, and screening of in vitro and in vivo pharmacological activities has significantly increased. Until now, however, fucoidans are only used as ingredients in cosmetics and food supplements, especially due to the proclaimed antioxidant activities of fucoidan...
July 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29690964/ultrasound-predictability-of-lower-uterine-segment-cesarean-section-scar-thickness
#7
Shazia Tazion, Maimoona Hafeez, Rukhsana Manzoor, Tashhir Rana
OBJECTIVE: The objective of this study is to find out association between scar thickness, assessed sonographically, and intraoperative findings (IOF). STUDY DESIGN: Descriptive study. PLACE AND DURATION OF STUDY: Department of Gynecology and Obstetrics, Sharif Medical and Dental College, Lahore, from June 2016 to April 2017. METHODOLOGY: A total of 70 pregnant patients were included in this study. Transabdominal ultrasound was done for scarred uteri...
May 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29690513/research-progress-on-rolling-circle-amplification-rca-based-biomedical-sensing
#8
REVIEW
Lide Gu, Wanli Yan, Le Liu, Shujun Wang, Xu Zhang, Mingsheng Lyu
Enhancing the limit of detection (LOD) is significant for crucial diseases. Cancer development could take more than 10 years, from one mutant cell to a visible tumor. Early diagnosis facilitates more effective treatment and leads to higher survival rate for cancer patients. Rolling circle amplification (RCA) is a simple and efficient isothermal enzymatic process that utilizes nuclease to generate long single stranded DNA (ssDNA) or RNA. The functional nucleic acid unit (aptamer, DNAzyme) could be replicated hundreds of times in a short period, and a lower LOD could be achieved if those units are combined with an enzymatic reaction, Surface Plasmon Resonance, electrochemical, or fluorescence detection, and other different kinds of biosensor...
April 21, 2018: Pharmaceuticals
https://www.readbyqxmd.com/read/29690495/self-assembly-behavior-of-amphiphilic-janus-dendrimers-in-water-a-combined-experimental-and-coarse-grained-molecular-dynamics-simulation-approach
#9
Mariana E Elizondo-García, Valeria Márquez-Miranda, Ingrid Araya-Durán, Jesús A Valencia-Gallegos, Fernando D González-Nilo
Amphiphilic Janus dendrimers (JDs) are repetitively branched molecules with hydrophilic and hydrophobic components that self-assemble in water to form a variety of morphologies, including vesicles analogous to liposomes with potential pharmaceutical and medical application. To date, the self-assembly of JDs has not been fully investigated thus it is important to gain insight into its mechanism and dependence on JDs’ molecular structure. In this study, the aggregation behavior in water of a second-generation bis-MPA JD was evaluated using experimental and computational methods...
April 21, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29689752/location-verification-algorithm-of-wearable-sensors-for-wireless-body-area-networks
#10
Hua Wang, Yingyou Wen, Dazhe Zhao
BACKGROUND: Knowledge of the location of sensor devices is crucial for many medical applications of wireless body area networks, as wearable sensors are designed to monitor vital signs of a patient while the wearer still has the freedom of movement. However, clinicians or patients can misplace the wearable sensors, thereby causing a mismatch between their physical locations and their correct target positions. An error of more than a few centimeters raises the risk of mistreating patients...
April 8, 2018: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/29689590/endometrial-ablation-past-present-and-future-part-i
#11
Morris Wortman
Endometrial ablation (EA) is a commonly performed minimally invasive technique to manage intractable uterine bleeding that is unresponsive to medical therapy. It originated in ancient times when chemical astringents were used to control uterine hemorrhage associated with childbirth and a variety of other gynecologic conditions. In the late 19th century, the use of astringents and chemical cauterants gave way to the application of a variety of thermal energy technologies to cause selective destruction of the endometrium...
April 23, 2018: Surgical Technology International
https://www.readbyqxmd.com/read/29689239/unmatched-integrated-cardiothoracic-surgery-program-applicants-where-do-they-end-up
#12
Trevor A Davis, Stephen C Yang
BACKGROUND: With the recent introduction of Integrated Cardiothoracic Surgery Residency Programs (IPs), limited data exists on unmatched applicants. We aimed to determine the dropout rate in individuals who applied IP but did not match. METHODS: An online IRB-approved survey was sent to current residents (n=409), provided by the Thoracic Surgery Directors Association, to evaluate preferences and pathway to Cardiothoracic Surgery (CTS). Descriptive analysis was performed on quantitative data...
April 21, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29688641/-concise-nanomedicine-review
#13
REVIEW
Menashe Haddad, Rachela Popovtzer, Inbar Yariv, Menachem Motiei, Dror Fixler
Nanomedicine is a rapidly evolving medical domain utilizing 1-100nm nanoscale particles to achieve medical goals in either one or more medical aspects - diagnosis, imaging and therapy. Nanomedicine employs a combination of methods stemming from life and exact sciences. This review deals briefly with the principles behind the scenes guiding the design, manufacture and employment of these nanoparticles. Some representative examples of the various applications are provided from the abundance of existing nanoparticles...
April 2018: Harefuah
https://www.readbyqxmd.com/read/29688494/discordance-between-serum-anti-m%C3%A3-llerian-hormone-concentrations-and-antral-follicle-counts-not-only-technical-issues
#14
M Š Alebic, N Stojanovic, D Dewailly
STUDY QUESTION: Do patient-specific features contribute to the differences between measured serum anti-Müllerian hormone (AMH) concentrations and AMH values expected from the corresponding antral follicle count (AFC)? SUMMARY ANSWER: Patient-specific features contribute to the differences between measured AMH values and AMH values expected from the corresponding AFC (AMHp), potentially through their effect on follicular AMH production. WHAT IS KNOWN ALREADY: Both patient counselling and patient management could be hampered by finding of disagreement between AFC and AMH if both are used for the prediction of ovarian response...
April 24, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29687922/analysis-of-carbohydrates-and-glycoconjugates-by-matrix-assisted-laser-desorption-ionization-mass-spectrometry-an-update-for-2013-2014
#15
REVIEW
David J Harvey
This review is the eighth update of the original article published in 1999 on the application of Matrix-assisted laser desorption/ionization mass spectrometry (MALDI) mass spectrometry to the analysis of carbohydrates and glycoconjugates and brings coverage of the literature to the end of 2014. Topics covered in the first part of the review include general aspects such as theory of the MALDI process, matrices, derivatization, MALDI imaging, fragmentation, and arrays. The second part of the review is devoted to applications to various structural types such as oligo- and poly- saccharides, glycoproteins, glycolipids, glycosides, and biopharmaceuticals...
April 17, 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/29687760/assessing-primary-care-data-quality
#16
Yvonne Mei Fong Lim, Maryati Yusof, Sheamini Sivasampu
Purpose The purpose of this paper is to assess National Medical Care Survey data quality. Design/methodology/approach Data completeness and representativeness were computed for all observations while other data quality measures were assessed using a 10 per cent sample from the National Medical Care Survey database; i.e., 12,569 primary care records from 189 public and private practices were included in the analysis. Findings Data field completion ranged from 69 to 100 per cent. Error rates for data transfer from paper to web-based application varied between 0...
April 16, 2018: International Journal of Health Care Quality Assurance
https://www.readbyqxmd.com/read/29687388/isolation-of-human-adipose-derived-stem-cells-from-lipoaspirates
#17
Jie Li, J Lowry Curley, Z Elizabeth Floyd, Xiying Wu, Yuan Di C Halvorsen, Jeffrey M Gimble
Adipose tissue is as an abundant and accessible source of stem cells with multipotent properties suitable for tissue engineering and regenerative medical applications. Here, we describe methods from our own laboratory and the literature for the isolation and expansion of adipose-derived stem cells (ASCs). We present a large scale procedure suitable for processing >100 mL volumes of lipoaspirate tissue specimens by collagenase digestion and a related procedure suitable for processing adipose tissue aspirates without digestion...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29687280/synthesis-characterization-antibacterial-activity-in-dark-and-in-vitro-cytocompatibility-of-ag-incorporated-tio-2-microspheres-with-high-specific-surface-area
#18
Shengxin Weng, Xu Zhao, Guomin Liu, Yuefeng Guan, Fanglong Wu, Yungang Luo
Postoperative infection associated with medical implants is a devastating complication of orthopedic surgery. Considering the difficulties for the diagnosis and treatment of infection, coating the implant material with antibacterial substances is a promising protocol by which to avoid such an adverse reaction. Nanoparticles (NPs) constructed of anatase microspheres, one form of titanium dioxide (TiO2 ), with a high specific surface area are fabricated in this study in a facile one-step process using homogeneous precipitation at 90 °C under atmospheric pressure using titanium sulfate (Ti[SO4 ]2 ) and urea as the titanium source and precipitant, respectively...
April 23, 2018: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/29686977/a-prototype-exercise-empowerment-mobile-video-game-for-children-with-cancer-and-its-usability-assessment-developing-digital-empowerment-interventions-for-pediatric-diseases
#19
Carol S Bruggers, Sabrina Baranowski, Mathew Beseris, Rachel Leonard, Derek Long, Elizabeth Schulte, Ashton Shorter, Rowan Stigner, Clinton C Mason, Alisa Bedrov, Ian Pascual, Grzegorz Bulaj
Background: Medical advances continue to improve morbidity and mortality of serious pediatric diseases, including cancer, driving research addressing diminished physical and psychological quality of life in children with these chronic conditions. Empowerment enhances resilience and positively influences health, disease, and therapy understanding. We describe the development and usability assessment of a prototype Empower Stars! mobile video game grounded in behavioral and exercise theories with the purpose of coupling physical exercise with empowerment over disease in children with cancer...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29686821/acute-effect-of-different-concentrations-of-cayenne-pepper-cataplasm-on-sensory-motor-functions-and-serum-levels-of-inflammation-related-biomarkers-in-healthy-subjects
#20
Nejc Sarabon, Stefan Löfler, Jan Cvecka, Wolfgang Hübl, Sandra Zampieri
Physical medicine therapies are often used in treating widespread musculoskeletal disorders, such as neck and low back pain. Herbal cataplasms containing rubefacient substances, such as Cayenne pepper, or galenic preparations like Munari cataplasm are commonly used as natural medications to treat painful areas. In this paper we show the effects of a 20-min application of Cayenne pepper and kaolin powder cataplasm (CPC) on healthy subjects. Treatment effects were evaluated by cold/hot feeling on visual analogue scale, blood pressure, body temperature, skin light touch sensations, two-point discrimination, and pain threshold to a mechanical stimulus, before and immediately after, 15 min after and 30 min after different concentration of Cayenne pepper in CPC preparation on healthy subjects...
January 12, 2018: European Journal of Translational Myology
keyword
keyword
17558
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"