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https://www.readbyqxmd.com/read/29050177/-application-of-three-dimensional-visualization-in-pancreatic-tumor-a-pilot-study
#1
S Z Wang, X B Wang, M Li, R X Shen, H Rong, J S Li
Objective: To study the value of three-dimensional(3D) visualization in the diagnosis and surgical treatment for pancreatic tumor. Methods: From June to September 2016, 26 patients with pancreatic tumors in Jinling Hospital, Medical School of Nanjing University were involved. The study included 26 patients(8 females and 18 males) with mean age of (57±12)years (ranging from 23 to 77 years). And there were 20 malignant tumors and 6 benign tumors. All of them were examined with abdominal thin slice CT scanning and the CT images were imported into 3D visualization system for 3D visualization...
October 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29049909/automatic-selection-of-localized-region-based-active-contour-models-using-image-content-analysis-applied-to-brain-tumor-segmentation
#2
Elisee Ilunga-Mbuyamba, Juan Gabriel Avina-Cervantes, Jonathan Cepeda-Negrete, Mario Alberto Ibarra-Manzano, Claire Chalopin
Brain tumor segmentation is a routine process in a clinical setting and provides useful information for diagnosis and treatment planning. Manual segmentation, performed by physicians or radiologists, is a time-consuming task due to the large quantity of medical data generated presently. Hence, automatic segmentation methods are needed, and several approaches have been introduced in recent years including the Localized Region-based Active Contour Model (LRACM). There are many popular LRACM, but each of them presents strong and weak points...
October 7, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29049671/application-of-a-discrete-choice-experiment-to-assess-adherence-related-motivation-among-adolescents-and-young-adults-with-cancer
#3
Meghan E McGrady, Lisa A Prosser, Aimee N Thompson, Ahna L H Pai
To develop and pilot test a discrete choice experiment (DCE) to assess the specific factors likely to motivate a given adolescent or young adult with cancer to adhere to medications included in treatment protocols. A multimethod and iterative approach was used. Twenty adolescents and young adults with cancer participated in DCE pilot testing and refinement. Hierarchical Bayes was used to estimate attribute and attribute-level preference scores for each participant. The final DCE included nine choice sets composed of four attributes...
July 25, 2017: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/29049553/evaluating-industry-payments-among-dermatology-clinical-practice-guidelines-authors
#4
Jake X Checketts, Matthew Thomas Sims, Matt Vassar
Importance: It is well documented that financial conflicts of interest influence medical research and clinical practice. Prior to the Open Payments provisions of the Affordable Care Act, financial ties became apparent only through self-disclosure. The nature of financial interests has not been studied among physicians who develop dermatology clinical practice guidelines. Objective: To evaluate payments received by physicians who author dermatology clinical practice guidelines, compare disclosure statements for accuracy, determine whether pharmaceutical companies from which the authors received payments manufactured products related to the guidelines, and examine the extent to which the American Academy of Dermatology enforced their Administrative Regulations for guideline development...
October 18, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/29049314/evaluation-of-characteristic-of-human-turbinate-derived-mesenchymal-stem-cells-cultured-in-the-serum-free-media
#5
Se Hwan Hwang, WeonSun Lee, Sang Hi Park, Hee Jin Lee, Sun Hwa Park, Dong Chang Lee, Mi Hyun Lim, Sang A Back, Byeong Gon Yun, Jung Ho Jeun, Jung Yeon Lim, Jun Myung Kang, Sung Won Kim
We evaluated the effect of serum-free and xeno-cultivation (SFXFM) on the characterization, proliferation, and differentiation properties of human nasal stem cells (airway tissue; hTMSCs). hTMSCs were isolated from 10 patients, after which patient samples were separated into two groups, an SFXFM group and a control group. The control group was treated with bovine serum-containing medium. FACS analysis revealed that SFXFM-cultured hTMSCs maintained a characteristic mesenchymal stem cell phenotype. hTMSC proliferation was not influenced by SFXFM...
2017: PloS One
https://www.readbyqxmd.com/read/29048394/photoplethysmography-signal-analysis-for-optimal-region-of-interest-determination-in-video-imaging-on-a-built-in-smartphone-under-different-conditions
#6
Yunyoung Nam, Yun-Cheol Nam
Smartphones and tablets are widely used in medical fields, which can improve healthcare and reduce healthcare costs. Many medical applications for smartphones and tablets have already been developed and widely used by both health professionals and patients. Specifically, video recordings of fingertips made using a smartphone camera contain a pulsatile component caused by the cardiac pulse equivalent to that present in a photoplethysmographic signal. By performing peak detection on the pulsatile signal, it is possible to estimate a continuous heart rate and a respiratory rate...
October 19, 2017: Sensors
https://www.readbyqxmd.com/read/29048241/nanofibrous-electrospun-hdecm-based-hybrid-scaffold-as-wound-dressing-for-reducing-scarring
#7
Tae Hee Kim, Youngmee Jung, Soo Hyun Kim
Produced via electrospinning, poly(l-lactide-co-caprolactone) (PLCL) membranes, which have a porous structure and are biodegradable, are of interest in various medical fields. The porous-structured electrospun membrane is particularly interesting because of several favorable properties: it exudes fluid from the wound, does not build up under the wound covering, and does not cause wound desiccation. Moreover, extracellular matrix (ECM)-based structures derived by tissue decellularization have application as engineered tissue scaffolds and as supports for cellular regeneration...
October 19, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29047394/esprit-ethics-committee-proposals-for-long-term-medical-data-registries-in-rapidly-evolving-research-fields-a-future-proof-best-practice-approach
#8
S Oberbichler, W O Hackl, A Hörbst
BACKGROUND: Long-term data collection is a challenging task in the domain of medical research. Many effects in medicine require long periods of time to become traceable e.g. the development of secondary malignancies based on a given radiotherapeutic treatment of the primary disease. Nevertheless, long-term studies often suffer from an initial lack of available information, thus disallowing a standardized approach for their approval by the ethics committee. This is due to several factors, such as the lack of existing case report forms or an explorative research approach in which data elements may change over time...
October 18, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/29047381/a-critical-appraisal-of-guidelines-used-for-management-of-severe-acute-malnutrition-in-south-africa-s-referral-system
#9
Faith Nankasa Mambulu-Chikankheni, John Eyles, Ejemai Amaize Eboreime, Prudence Ditlopo
BACKGROUND: Focusing on healthcare referral processes for children with severe acute malnutrition (SAM) in South Africa, this paper discusses the comprehensiveness of documents (global and national) that guide the country's SAM healthcare. This research is relevant because South African studies on SAM mostly examine the implementation of WHO guidelines in hospitals, making their technical relevance to the country's lower level and referral healthcare system under-explored. METHODS: To add to both literature and methods for studying SAM healthcare, we critically appraised four child healthcare guidelines (global and national) and conducted complementary expert interviews (n = 5)...
October 18, 2017: Health Research Policy and Systems
https://www.readbyqxmd.com/read/29047370/the-recent-development-and-applications-of-fluidic-channels-by-3d-printing
#10
REVIEW
Yufeng Zhou
The technology of "Lab-on-a-Chip" allows the synthesis and analysis of chemicals and biological substance within a portable or handheld device. The 3D printed structures enable precise control of various geometries. The combination of these two technologies in recent years makes a significant progress. The current approaches of 3D printing, such as stereolithography, polyjet, and fused deposition modeling, are introduced. Their manufacture specifications, such as surface roughness, resolution, replication fidelity, cost, and fabrication time, are compared with each other...
October 18, 2017: Journal of Biomedical Science
https://www.readbyqxmd.com/read/29046925/-clinical-anamnestic-characteristics-in-neurological-work-related-medical-rehabilitation-necessity-for-a%C3%A2-qualitative-identification-of-severe-restrictions-of-work-ability
#11
A Heßling, I Brandes, M-L Dierks, T Leniger
BACKGROUND: Severe restrictions of work ability (SRWA) as a condition for participation in neurological work-related medical rehabilitation (WMR) have not been adequately described up to now. Similarly, the applicability of the screening instrument SIMBO-C for evaluating SRWA in neurological rehabilitation has not yet been answered conclusively. OBJECTIVE: Determination of clinical and anamnestic characteristics of neurological SRWA and assessment of the applicability of the screening instrument SIMBO-C in neurological WMR...
October 18, 2017: Der Nervenarzt
https://www.readbyqxmd.com/read/29046431/a-survey-of-perceived-effectiveness-of-part-4-maintenance-of-certification
#12
Joel S Tieder, Sean P Prall, Jimmy Beck, Erin Alberda, Debra Jensen, Deepthi Nair, Jan D Carline
OBJECTIVES: Evaluative assessment is needed to inform improvement of Part 4 Maintenance of Certification (MOC), a large-scale program that aims to improve physician knowledge, engagement, and skills in quality improvement (QI). We sought to determine if Part 4 MOC participation improves perceived educational and clinical outcomes by piloting a new physician survey. METHODS: We administered a new online survey (MOC Practice, Engagement, Attitude, and Knowledge Survey) to physicians at the beginning and end of a Part 4 MOC project sponsored by a pediatric hospital's American Board of Medical Specialties' portfolio program during 2015...
October 18, 2017: Hospital Pediatrics
https://www.readbyqxmd.com/read/29046212/-research-advances-in-hereditary-epilepsy-and-precision-drug-therapy
#13
Ge Lyu, Yun-Li Han
Epilepsy is a common nervous system disease. It has been found that the pathogenesis of epilepsy is associated mutations in various genes, including genes encoding voltage-dependent ion channel, genes encoding ligand-gated ion channel, and solute carrier family genes. Different types of epilepsy caused by different mutations have different responses to drugs, and therefore, diagnosis and medication guidance based on genes are new thoughts for developing therapies. With the application of next-generation sequencing technology, more and more genes will be determined, which helps to further study the pathogenic mechanism of mutant genes and provides a basis for precision drug therapy for epilepsy...
October 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29045667/survey-of-reproductive-experiences-and-outcomes-of-cancer-survivors-who-stored-reproductive-material-before-treatment
#14
K Hammarberg, M Kirkman, C Stern, R I McLachlan, G Clarke, F Agresta, D Gook, L Rombauts, B Vollenhoven, J R W Fishe
STUDY QUESTION: What are the reproductive experiences and outcomes of people who store reproductive material before cancer treatment? SUMMARY ANSWER: Of respondents who had tried to achieve pregnancy since completing cancer treatment almost all had succeeded, in most cases through natural conception. WHAT IS KNOWN ALREADY: People of reproductive age who are diagnosed with cancer can cryopreserve reproductive material to guard against the adverse effects on fertility of gonadotoxic treatment...
October 17, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29045609/stakeholder-perspectives-on-the-optimizing-patient-transfers-impacting-medical-quality-and-improving-symptoms-transforming-institutional-care-optimistic-project
#15
Mary Ersek, Susan E Hickman, Anne C Thomas, Brittany Bernard, Kathleen T Unroe, Suzanne Meeks
Background and Objectives: The need to reduce burdensome and costly hospitalizations of frail nursing home residents is well documented. The Optimizing Patient Transfers, Impacting Medical Quality, and Improving Symptoms: Transforming Institutional Care (OPTIMISTIC) project achieved this reduction through a multicomponent collaborative care model. We conducted an implementation-focused project evaluation to describe stakeholders' perspectives on (a) the most and least effective components of the intervention; (b) barriers to implementation; and (c) program features that promoted its adoption...
October 17, 2017: Gerontologist
https://www.readbyqxmd.com/read/29045504/molecular-tumor-boards-current-practice-and-future-needs
#16
D L van der Velden, C M L van Herpen, H W M van Laarhoven, E F Smit, H J M Groen, S M Willems, P M Nederlof, M H G Langenberg, E Cuppen, S Sleijfer, N Steeghs, E E Voest
Background: due to rapid technical advances, steeply declining sequencing costs, and the ever-increasing number of targeted therapies, it can be expected that extensive tumor sequencing such as Whole Exome- and -Genome Sequencing will soon be applied in standard care. Clinicians will thus be confronted with increasingly complex genetic information and multiple test-platforms to choose from. General medical training, meanwhile, can hardly keep up with the pace of innovation. Consequently, there is a rapidly growing gap between clinical knowledge and genetic potential in cancer care...
September 27, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29045274/recruiting-american-indian-alaska-native-students-to-medical-school-a-multi-institutional-alliance-in-the-u-s-southwest
#17
Marlene P Ballejos, Polly Olsen, Tanisha Price-Johnson, Cindy Garcia, Tassy Parker, Robert E Sapién, Valerie Romero-Leggott
PROBLEM: Despite national efforts to diversify the physician workforce, American Indian/Alaska Native (AI/AN) individuals have the least representation of all major racial and ethnic groups. Limited resources at state medical schools present institution-level recruitment challenges. Unified efforts to engage AI/AN students in premedical education activities are needed. APPROACH: The medical schools at the Universities of Arizona (Phoenix and Tucson), Colorado, New Mexico, and Utah identified a collective need to increase student diversity, particularly with regard to AI/AN students...
October 17, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29045237/monoplane-3d-2d-registration-of-cerebral-angiograms-based-on-multi-objective-stratified-optimization
#18
Timur Aksoy, Ziga Spiclin, Franjo Pernus, Gozde Unal
Registration of 3D pre-interventional to 2D intra-interventional medical images has an increasingly important role in surgical planning, navigation and treatment, because it enables the physician to co-locate depth information given by pre-interventional 3D images with the live information in intra-interventional 2D images such as X-ray. Most tasks during image-guided interventions are carried out under a monoplane X-ray, which is a highly ill-posed problem for state-of-the-art 3D to 2D registration methods...
October 18, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29045058/loop-mediated-isothermal-amplification-lamp-as-an-alternative-to-pcr-a-rapid-on-site-detection-of-gene-doping
#19
Olivier Salamin, Tiia Kuuranne, Martial Saugy, Nicolas Leuenberger
Innovation in medical research has been diverted at multiple occasions to enhance human performance. The predicted great progress in gene therapy has raised some concerns regarding its misuse in the world of sports (gene doping) for several years now. Even though there is no evidence that gene doping has ever been used in sports, the continuous improvement of gene therapy techniques increases the likelihood of abuse. Therefore, since 2004, efforts have been invested by the anti-doping community and WADA for the development of detection methods...
October 17, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29044983/horseradish-peroxidase-catalyzed-hydrogelation-for-biomedical-biopharmaceutical-and-biofabrication-applications
#20
Shinji Sakai, Masaki Nakahata
Horseradish peroxidase (HRP)-catalyzed hydrogelation has attracted much attention due to the ease of handling, high biocompatibility, and processability. This review summarizes recent developments including cutting-edge research using HRP-mediated hydrogelation toward biomedical, biopharmaceutical, and biofabrication applications. From the viewpoint of polymer chemistry, the basic chemistry behind hydrogelation, the structure-property relationship, and hybridization of multiple materials using HRP-catalyzed hydrogelation are summarized...
October 18, 2017: Chemistry, An Asian Journal
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