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https://www.readbyqxmd.com/read/27926561/percutaneous-posterior-tibial-nerve-stimulation-vs-perianal-application-of-glyceryl-trinitrate-ointment-in-the-treatment-of-chronic-anal-fissure-a-randomized-clinical-trial
#1
Jaime Ruiz-Tovar, Carolina Llavero
BACKGROUND: Current therapeutic guidelines for the treatment of chronic anal fissure establish a medical approach as the first step. Glyceryl trinitrate ointment is the most popular of the available topical treatments in Spain but it is associated with the appearance of headache. OBJECTIVE: The purpose of this study was to compare the compliance rate among patients receiving glyceryl trinitrate treatment for chronic anal fissure with that among patients receiving percutaneous posterior tibial nerve stimulation...
January 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/27926378/automated-segmentation-of-white-matter-fiber-bundles-using-diffusion-tensor-imaging-data-and-a-new-density-based-clustering-algorithm
#2
Tahereh Kamali, Daniel Stashuk
OBJECTIVE: Robust and accurate segmentation of brain white matter (WM) fiber bundles assists in diagnosing and assessing progression or remission of neuropsychiatric diseases such as schizophrenia, autism and depression. Supervised segmentation methods are infeasible in most applications since generating gold standards is too costly. Hence, there is a growing interest in designing unsupervised methods. However, most conventional unsupervised methods require the number of clusters be known in advance which is not possible in most applications...
October 2016: Artificial Intelligence in Medicine
https://www.readbyqxmd.com/read/27925241/vertebral-subluxation-repair-in-a-pet-goat
#3
Sara Nannarone, Enrico Bellezza, Yves P Moens, Paula Larenza Menzies
OBJECTIVES: To describe the perioperative management, including surgery, anesthesia, metabolic derangements, and physiotherapy, in a goat referred for paraparesis secondary to a road traffic accident. STUDY DESIGN: Case report. ANIMALS: 2-year-old mixed breed dwarf 44 kg female pet goat. METHODS: Clinical examination showed symptoms of early compensatory stages of shock, paraparesis with hyperextension of the thoracic limbs, pain on palpation of the thoracolumbar spine, increased patellar reflexes of both pelvic limbs without superficial sensitivity, but preserved deep pain sensation...
December 7, 2016: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/27925048/resting-energy-expenditure-in-critically-ill-patients-evaluation-methods-and-clinical-applications
#4
Ana Cláudia Soncini Sanches, Cassiana Regina de Góes, Marina Nogueira Berbel Bufarah, André Luiz Balbi, Daniela Ponce
Patients on intensive care present systemic, metabolic, and hormonal alterations that may adversely affect their nutritional condition and lead to fast and important depletion of lean mass and malnutrition. Several factors and medical conditions can influence the energy expenditure (EE) of critically ill patients, such as age, gender, surgery, serious infections, medications, ventilation modality, and organ dysfunction. Clinical conditions that can present with EE change include acute kidney injury, a complex disorder commonly seen in critically ill patients with manifestations that can range from minimum elevations in serum creatinine to renal failure requiring dialysis...
October 2016: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/27924943/gsy-a-novel-glucansucrase-from-leuconostoc-mesenteroides-mediates-the-formation-of-cell-aggregates-in-response-to-oxidative-stress
#5
Minghui Yan, Jin Han, Xiaofen Xu, Lianliang Liu, Caixia Gao, Huajun Zheng, Yunxia Chen, Yimin Tao, Hu Zhou, Yunfei Li, Zhengjun Wu
Leuconostoc mesenteroides is a member of lactic acid bacteria (LAB) with wide applications in the food and medical industries. Species in the genus Leuconostoc are catalase-negative and generally regarded as facultative anaerobic or aerotolerant organisms. Despite their extensive use in industry, certain issues concerning the aerobic life of L. mesenteroides, e.g., the mechanism involved in the tolerance to oxygen, remain to be addressed. In this manuscript, a survival strategy employed by L. mesenteroides BD3749 in response to oxidative stress was elucidated...
December 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27924518/application-of-paclitaxel-as-adjuvant-treatment-for-benign-cicatricial-airway-stenosis
#6
Xiao-Jian Qiu, Jie Zhang, Juan Wang, Yu-Ling Wang, Min Xu
Benign cicatricial airway stenosis (BCAS) is a potentially life-threatening disease. Recurrence occurs frequently after endoscopic treatment. Paclitaxel is known to prevent restenosis, but its clinical efficacy and safety is undetermined. Therefore, in this study, we investigated the efficacy and associated complications of paclitaxel as adjuvant treatment for BCAS of different etiologies. The study cohort included 28 patients with BCAS resulting from tuberculosis, intubation, tracheotomy, and other etiologies...
December 2016: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/27924427/treatment-of-medication-related-osteonecrosis-of-the-jaws-mronj-with-ultrasonic-piezoelectric-bone-surgery-a-case-series-of-20-treated-sites
#7
Cornelio Blus, Giulio Giannelli, Serge Szmukler-Moncler, Germano Orru
PURPOSE: There is no consensus on how to successfully treat medication-related osteonecrosis of the jaws (MRONJ). We report here on the application of piezoelectric bone surgery to treat MRONJ in combination with antibiotherapy and on its possible benefit. MATERIEL AND METHODS: A cohort of 18 consecutive patients has been treated for MRONJ; they involved 20 sites, 15 in the mandible, and five in the maxilla. Surgical removal of the necrotic areas and debridement was performed with a powerful piezoelectric surgery device (max 90 W) in combination with antibiotherapy...
December 6, 2016: Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27924350/-use-of-intracutaneous-or-subcutaneous-botulinum-toxin-for-postherpetic-neuralgia
#8
L Halb, B J Amann, H Bornemann-Cimenti
BACKGROUND: Botulinum neurotoxin (BoNT), a toxin of the anaerobic spore-forming bacterium Clostridium botulinum is used as a drug for alleviating muscle spasticity. Other indications include the cosmetic application in facial muscles, hyperhidrosis and neurogenic bladder disorders. It has been approved since 2010 as the first prophylactic treatment for chronic migraine. The analgesic effect of BoNT was observed early on and is currently the subject of intensive research. Painful postherpetic neuralgia is a common complication of an infection with herpes zoster virus...
December 6, 2016: Der Nervenarzt
https://www.readbyqxmd.com/read/27924337/allosteric-effects-of-gold-nanoparticles-on-human-serum-albumin
#9
Qing Shao, Carol K Hall
The ability of nanoparticles to alter protein structure and dynamics plays an important role in their medical and biological applications. We investigate allosteric effects of gold nanoparticles on human serum albumin protein using molecular simulations. The extent to which bound nanoparticles influence the structure and dynamics of residues distant from the binding site is analyzed. The root mean square deviation, root mean square fluctuation and variation in the secondary structure of individual residues on a human serum albumin protein are calculated for four protein-gold nanoparticle binding complexes...
December 7, 2016: Nanoscale
https://www.readbyqxmd.com/read/27924039/flyrnai-org-the-database-of-the-drosophila-rnai-screening-center-and-transgenic-rnai-project-2017-update
#10
Yanhui Hu, Aram Comjean, Charles Roesel, Arunachalam Vinayagam, Ian Flockhart, Jonathan Zirin, Lizabeth Perkins, Norbert Perrimon, Stephanie E Mohr
The FlyRNAi database of the Drosophila RNAi Screening Center (DRSC) and Transgenic RNAi Project (TRiP) at Harvard Medical School and associated DRSC/TRiP Functional Genomics Resources website (http://fgr.hms.harvard.edu) serve as a reagent production tracking system, screen data repository, and portal to the community. Through this portal, we make available protocols, online tools, and other resources useful to researchers at all stages of high-throughput functional genomics screening, from assay design and reagent identification to data analysis and interpretation...
October 23, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27923764/applications-of-deep-eutectic-solvents-in-biotechnology-and-bioengineering-promises-and-challenges
#11
REVIEW
Yves Paul Mbous, Maan Hayyan, Adeeb Hayyan, Won Fen Wong, Mohd Ali Hashim, Chung Yeng Looi
Deep eutectic solvents (DESs) have been touted recently as potential alternatives to ionic liquids (ILs). Although they possess core characteristics that are similar to those of ILs (e.g., low volatility, non-flammability, low melting points, low vapor pressure, dipolar nature, chemical and thermal stability, high solubility, and tuneability), DESs are superior in terms of the availability of raw materials, the ease of storage and synthesis, and the low cost of their starting materials. As such, they have become the subject of intensive research in various sectors, notably the chemical, electrochemical, and biological sectors...
December 3, 2016: Biotechnology Advances
https://www.readbyqxmd.com/read/27923165/outpatient-versus-inpatient-cervix-priming-with-foley-catheter-a-randomized-trial
#12
Catarina Policiano, Mariana Pimenta, Diana Martins, Nuno Clode
OBJECTIVE: To compare clinical efficacy between outpatient and inpatient cervix priming with Foley catheter. STUDY DESIGN: We conducted a randomized trial including term pregnancies with a single fetus in cephalic presentation, Bishop score<6, gestational age>41 weeks or medical indication for induction of labor. Patients were randomized to outpatient (n=65) or inpatient (n=65) priming with Foley catheter. Primary outcome was Bishop score change between outpatient and inpatient groups...
November 27, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27923012/using-mhealth-for-hiv-tb-treatment-support-in-lesotho-enhancing-patient-provider-communication-in-the-start-study
#13
Yael Hirsch-Moverman, Amrita Daftary, Katharine A Yuengling, Suzue Saito, Moeketsi Ntoane, Koen Frederix, Llang B Maama, Andrea A Howard
BACKGROUND: mHealth is a promising means of supporting adherence to treatment. The Start TB patients on ART and Retain on Treatment (START) study included real-time adherence support using short-text messaging service (SMS) text messaging and trained village health workers (VHWs). We describe the use and acceptability of mHealth by patients with HIV/tuberculosis and health care providers. METHODS: Patients and treatment supporters received automated, coded medication and appointment reminders at their preferred time and frequency, using their own phones, and $3...
January 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27922974/training-and-validating-a-deep-convolutional-neural-network-for-computer-aided-detection-and-classification-of-abnormalities-on-frontal-chest-radiographs
#14
Mark Cicero, Alexander Bilbily, Errol Colak, Tim Dowdell, Bruce Gray, Kuhan Perampaladas, Joseph Barfett
OBJECTIVES: Convolutional neural networks (CNNs) are a subtype of artificial neural network that have shown strong performance in computer vision tasks including image classification. To date, there has been limited application of CNNs to chest radiographs, the most frequently performed medical imaging study. We hypothesize CNNs can learn to classify frontal chest radiographs according to common findings from a sufficiently large data set. MATERIALS AND METHODS: Our institution's research ethics board approved a single-center retrospective review of 35,038 adult posterior-anterior chest radiographs and final reports performed between 2005 and 2015 (56% men, average age of 56, patient type: 24% inpatient, 39% outpatient, 37% emergency department) with a waiver for informed consent...
December 5, 2016: Investigative Radiology
https://www.readbyqxmd.com/read/27922580/comparative-analysis-of-peri-operative-outcomes-using-nationally-derived-hospital-discharge-data-relative-to-a-prospective-multi-center-surgical-database-of-adult-spinal-deformity-surgery
#15
Gregory W Poorman, Peter G Passias, Aaron J Buckland, Cyrus M Jalai, Michael Kelly, Daniel M Sciubba, Brian J Neuman, D Kojo Hamilton, Amit Jain, Bassel Diebo, Virginie Lafage, Shay Bess, Eric O Klineberg
STUDY DESIGN: Retrospective analysis of three prospectively collected databases. OBJECTIVE: compare peri-operative outcomes in Adult Spinal Deformity (ASD) surgeries in a surgeon-run (SR-ASD) and two national databases: the Nationwide Inpatient Sample (NIS) and the National Surgical Quality Improvement Program (NSQIP). SUMMARY OF BACKGROUND DATA: has been learned on the treatment of ASD in the last decade with prospective multicenter collaborative research focusing on this specific condition...
December 2, 2016: Spine
https://www.readbyqxmd.com/read/27922454/a-clinician-s-guide-to-privacy-and-communication-in-the-icu
#16
Leslie Francis, Micah A Vorwaller, Hanan Aboumatar, Dominick L Frosch, John Halamka, Ronen Rozenblum, Eileen Rubin, Barbara Sarnoff Lee, Jeremy Sugarman, Kathleen Turner, Samuel M Brown
OBJECTIVE: To review the legal issues concerning family members' access to information when patients are in the ICU. DATA SOURCES: U.S. Code, U.S. Code of Federal Regulations, and state legislative codes. DATA EXTRACTION: Relevant legal statutes and regulations were identified and reviewed by the two attorney authors (L. F., M. A. V.). STUDY SELECTION: Not applicable. DATA SYNTHESIS: Review by all coauthors...
December 2, 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27921323/the-application-of-strand-invasion-phenomenon-directed-by-peptide-nucleic-acid-pna-and-single-stranded-dna-binding-protein-ssb-for-the-recognition-of-specific-sequences-of-human-endogenous-retroviral-herv-w-family
#17
Grzegorz Machnik, Łukasz Bułdak, Jarosław Ruczyński, Tomasz Gąsior, Małgorzata Huzarska, Dariusz Belowski, Magdalena Alenowicz, Piotr Mucha, Piotr Rekowski, Bogusław Okopień
The HERV-W family of human endogenous retroviruses represents a group of numerous sequences that show close similarity in genetic composition. It has been documented that some members of HERV-W-derived expression products are supposed to play significant role in humans' pathology, such as multiple sclerosis or schizophrenia. Other members of the family are necessary to orchestrate physiological processes (eg, ERVWE1 coding syncytin-1 that is engaged in syncytiotrophoblast formation). Therefore, an assay that would allow the recognition of particular form of HERV-W members is highly desirable...
December 6, 2016: Journal of Molecular Recognition: JMR
https://www.readbyqxmd.com/read/27921072/anatomy-based-algorithm-for-automatic-segmentation-of-human-diaphragm-in-noncontrast-computed-tomography-images
#18
Elham Karami, Yong Wang, Stewart Gaede, Ting-Yim Lee, Abbas Samani
In-depth understanding of the diaphragm's anatomy and physiology has been of great interest to the medical community, as it is the most important muscle of the respiratory system. While noncontrast four-dimensional (4-D) computed tomography (CT) imaging provides an interesting opportunity for effective acquisition of anatomical and/or functional information from a single modality, segmenting the diaphragm in such images is very challenging not only because of the diaphragm's lack of image contrast with its surrounding organs but also because of respiration-induced motion artifacts in 4-D CT images...
October 2016: Journal of Medical Imaging
https://www.readbyqxmd.com/read/27920940/3d-printing-in-neurosurgery-a-systematic-review
#19
REVIEW
Michael Randazzo, Jared M Pisapia, Nickpreet Singh, Jayesh P Thawani
BACKGROUND: The recent expansion of three-dimensional (3D) printing technology into the field of neurosurgery has prompted a widespread investigation of its utility. In this article, we review the current body of literature describing rapid prototyping techniques with applications to the practice of neurosurgery. METHODS: An extensive and systematic search of the Compendex, Scopus, and PubMed medical databases was conducted using keywords relating to 3D printing and neurosurgery...
2016: Surgical Neurology International
https://www.readbyqxmd.com/read/27920899/diagnosing-clean-margins-through-raman-spectroscopy-in-human-and-animal-mammary-tumour-surgery-a-short-review
#20
REVIEW
I A Birtoiu, C Rizea, D Togoe, R M Munteanu, C Micsa, M I Rusu, M Tautan, L Braic, L O Scoicaru, A Parau, N D Becherescu-Barbu, M V Udrea, A Tonetto, R Notonier, C E A Grigorescu
Breast cancer frequency in human and other mammal female populations has worryingly increased lately. The acute necessity for taxonomy of the aetiological factors along with seeking for new diagnostic tools and therapy procedures aimed at reducing mortality have yielded in an intense research effort worldwide. Surgery is a regular method to counteract extensive development of breast cancer and prevent metastases provided that negative surgical margins are achieved. This highly technical challenge requires fast, extremely sensitive and selective discrimination between malignant and benign tissues even down to molecular level...
December 6, 2016: Interface Focus
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