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https://www.readbyqxmd.com/read/28241719/-clinical-application-of-three-dimensional-o-arm-navigation-system-in-treating-patients-with-dystrophic-scoliosis-secondary-to-neurofibromatosis-type-%C3%A2
#1
Z Liu, Y Qiu, Y Li, Z H Zhao, B Wang, F Zhu, Y Yu, X Sun, Z Z Zhu
Objective: To investigate the clinical outcomes and the accuracy of O-arm-navigation system assisted pedicle screw insertion in dystrophic scoliosis secondary to neurofibromatosis type Ⅰ(NF-1). Methods: A retrospective study was conducted in 41 patients with dystrophic NF-1-associated thoracic scoliosis who were surgically treated at Department of Orthopaedics, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School between June 2012 and October 2014 with more than 18 months follow-up...
March 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/28241717/-application-of-three-dimensional-printing-personalized-acetabular-wing-plate-in-treatment-of-complex-acetabular-fractures-via-lateral-rectus-approach
#2
J G Mai, C Gu, X Z Lin, T Li, W Q Huang, H Wang, X Y Tan, H Lin, Y M Wang, Y Q Yang, D D Jin, S C Fan
Objective: To investigate reduction and fixation of complex acetabular fractures using three-dimensional (3D) printing technique and personalized acetabular wing-plate via lateral-rectus approach. Methods: From March to July 2016, 8 patients with complex acetabular fractures were surgically managed through 3D printing personalized acetabular wing-plate via lateral-rectus approach at Department of Orthopedics, the Third Affiliated Hospital of Southern Medical University. There were 4 male patients and 4 female patients, with an average age of 57 years (ranging from 31 to 76 years)...
March 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/28241514/antivenom-evaluation-by-electrophysiological-analysis
#3
Rita Restano-Cassulini, Walter Garcia, Jorge F Paniagua-Solís, Lourival D Possani
Scorpion stings on humans are medically relevant because they may contain toxins that specifically target ion channels. During antivenom production, pharmaceutical companies must use a large number of experimental animals to ensure the antivenom's efficacy according to pharmacopeia methods. Here we present an electrophysiological alternative for the evaluation of horse antivenoms produced against two species of Moroccan scorpions: Buthus mardochei and Androctonus mauretanicus. Human sodium and potassium channels and acetylcholine nicotinic receptors were analyzed by standard patch-clamp techniques...
February 23, 2017: Toxins
https://www.readbyqxmd.com/read/28241330/a-qualitative-interview-based-study-of-the-health-policy-fellowship-s-osteopathic-identity
#4
Daniel Skinner, Berkeley Franz
CONTEXT: Since 1993, the Health Policy Fellowship (HPF) has trained osteopathic professionals in health policy and leadership. Although almost 250 fellows have graduated from the program, many of whom have assumed leadership roles within the osteopathic medical profession, the HPF has, to the authors' knowledge, never been subjected to scholarly analysis. OBJECTIVE: To understand the HPF's professional significance as a health policy and leadership training program that has enrolled mostly osteopathic physicians...
March 1, 2017: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/28241329/osteopathic-medical-student-practice-of-osteopathic-manipulative-treatment-during-school-break
#5
Stacey Pierce-Talsma, R Mitchell Hiserote, Gregg Lund
CONTEXT: Osteopathic manipulative treatment (OMT) is integral in osteopathic medical education. The timing of the loss of interest, leading to decreasing clinical use, is unclear. Osteopathic medical students' activities during laboratories or rotations are determined by laboratory or preceptor requirements and do not characterize students' interest in or how they value OMT. Students who practice OMT when they are not required to may demonstrate that they are interested in, perceive a positive value of, and have confidence in using OMT...
March 1, 2017: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/28241301/battle-of-the-bulge-aortic-aneurysm-management-from-early-modernity-to-the-present
#6
Justin Barr
For centuries, physicians have recognized aortic aneurysms as an acute threat to life. Therapeutic approaches to the disease began in the 18th century when leading physicians, such as René Laennec and Antonio Valsalva, applied research on circulation and blood coagulation to devise whole-body fasting and bleeding regimens to prevent rupture. After John Hunter's success in ligating arteries to treat peripheral aneurysms, surgeons attempted analogous operations on the aorta, but even the renowned Sir Astley Cooper and William Halsted met with disastrous results...
February 21, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28241174/endoscopic-management-of-subglottic-stenosis
#7
Aaron J Feinstein, Alex Goel, Govind Raghavan, Jennifer Long, Dinesh K Chhetri, Gerald S Berke, Abie H Mendelsohn
Importance: Optimal management of subglottic stenosis has not been established. Endoscopic techniques include balloon dilation, radial incisions with carbon dioxide laser or cold knife, and combinations of techniques. Adjunctive measures include mitomycin application and glucocorticoid injection. Objective: To determine whether surgical technique or adjunctive measures are associated with duration between surgical procedures. Design, Setting, and Participants: Adult patients with subglottic stenosis treated endoscopically between 1995-2015 at a quaternary academic medical center were identified...
February 23, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28240815/antimicrobial-and-immunomodulatory-surface-functionalized-electrospun-membranes-for-bone-regeneration
#8
Asha Mathew, Cedryck Vaquette, Saeed Hashimi, Irani Rathnayake, Flavia Huygens, Dietmar W Hutmacher, Saso Ivanovski
Guided bone regeneration (GBR) is a surgical procedure utilizing occlusive membranes for providing space maintenance and enabling selective repopulation of the damaged area. While this technique is effective in regenerating bone, bacterial infiltration occurs frequently and can compromise the regenerative outcome. In this study, the authors describe the development and characterization of a GBR membrane made of medical grade polycaprolactone (mPCL) electrospun fibers with antibacterial and immunomodulatory properties...
February 27, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28240813/fabrication-and-characterization-of-conductive-conjugated-polymer-coated-antheraea-mylitta-silk-fibroin-fibers-for-biomedical-applications
#9
Darshan Gh, Dexu Kong, Julien Gautrot, Shyam Kumar Vootla
Conductive polymers are interesting materials for a number of biological and medical applications requiring electrical stimulation of cells or tissues. Highly conductive polymers (polypyrrole and polyaniline)/Antheraea mylitta silk fibroin coated fibers are fabricated successfully by in situ polymerization without any modification of the native silk fibroin. Coated fibers characterized by scanning electron microscopy confirm the silk fiber surface is covered by conductive polymers. Thermogravimetric analysis reveals preserved thermal stability of silk fiber after coating process...
February 27, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28240543/an-integrated-analytical-and-statistical-two-dimensional-spectroscopy-strategy-for-metabolite-identification-application-to-dietary-biomarkers
#10
Joram M Posma, Isabel Garcia-Perez, James Christopher Heaton, Paula Burdisso, John C Mathers, John Draper, Matthew R Lewis, John C Lindon, Gary S Frost, Elaine Holmes, Jeremy Kirk Nicholson
A major purpose of exploratory metabolic profiling is for the identification of molecular species that are statistically associated with specific biological or medical outcomes; unfortunately the structure elucidation process of unknowns is often a major bottleneck in this process. We present here new holistic strategies that combine different statistical spectroscopic and analytical techniques to improve and simplify the process of metabolite identification. We exemplify these strategies using study data collected as part of a dietary intervention to improve health and which elicits a relatively subtle suite of changes from complex molecular profiles...
February 27, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28240541/viscosity-measurements-using-microfluidic-droplet-length
#11
Yunzi Li, Kevin R Ward, Mark A Burns
Viscosity measurements have a wide range of applications from industrial chemical production to medical diagnosis. In this work, we have developed a simple droplet-based, water-in-oil continuous viscometer capable of measuring viscosity changes in 10 seconds or less and consuming a total sample volume of less than 1 µl per hour. The viscometer employs a flow-focusing geometry and generates droplets under constant pressure. The length of the droplets (Ld) is highly correlated to the aqueous-phase viscosity (µaq) at high ratios of aqueous-inlet to oil-inlet pressure (AIP/OIP), yielding a linear relationship between µaq and 1/(Ld - Lc) where Lc is the minimal obtainable droplet length and approximately equals to the width of the droplet-generating channel...
February 27, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28240502/smartphone-smart-surgeon-what-about-a-smart-logbook
#12
A Adam, K Spencer, S Moon, I Jacub
BACKGROUND: Mobile phone applications (Apps) have become a vital assistant to medical personnel in today's technologically advanced era. The utility of Apps with case logbook capabilities has not yet been explored. OBJECTIVE: To assess and evaluate all currently available surgical and procedural case logbook Apps. METHOD: A comprehensive search was conducted in April 2015 on the Android Play Store, iTunes (Apple App Store, iOS), and BlackBerry World for surgical and/or procedural logbooks...
June 2016: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28240175/clinical-considerations-of-focal-drug-delivery-in-cancer-treatment
#13
Jamie Harris, Bill Chiu
According to the US Center for Disease Control, cancer deaths are the second most common cause of mortality in both adults and children. Definitive treatment of solid tumors involves surgical resection with or without systemic chemotherapy and radiation. The advent of local drug delivery presents a unique treatment modality that can offer substantial benefits in cancer management. Local drug delivery offers targeted drug delivery to cancer tissues while minimizing side effects of the medications. Three main phases in solid tumor management exist for the treating physician: initial diagnosis with tissue biopsy, surgical resection with or without chemotherapy, and management of metastatic disease...
February 24, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28240172/clinical-applications-of-personalized-medicine-a-new-paradigm-and-challenge
#14
Mariantonia Di Sanzo, Vittorio Fineschi, Marina Borro, Raffaele La Russa, Alessandro Santurro, Matteo Scopetti, Maurizio Simmaco, Paola Frati
The personalized medicine is an emergent and rapidly developing method of clinical practice that uses new technologies to provide decisions in regard to the prediction, prevention, diagnosis and treatment of disease. The continue evolution of technology and the developments in molecular diagnostics and genomic analysis increased the possibility of an even more understanding and interpretation of the human genome and exome, allowing a "personalized" approach to clinical care, so that the concepts of "Systems Medicine" and "System Biology" are increasingly actual...
February 23, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28240027/transport-limited-adsorption-of-plasma-proteins-on-bimodal-amphiphilic-polymer-co-networks-real-time-studies-by-spectroscopic-ellipsometry
#15
Gustavo Andres Guzman, Sarang M Bhaway, Turgut Nugay, Bryan D Vogt, Mukerrem Miko Cakmak
Traditional hydrogels are commonly limited by poor mechanical properties and low oxygen permeability. Bimodal amphiphilic co-networks (β-APCNs) are a new class of materials that can overcome these limitations by combining hydrophilic and hydrophobic polymer chains within a network of co-continuous morphology. Applications that can benefit from these improved properties include therapeutic contact lenses, enzymatic catalysis supports and immunoisolation membranes. The continuous hydrophobic phase could potentially increase the adsorption of plasma proteins in blood-contacting medical applications and compromise in-vivo material performance, so it is critical to understand the surface characteristics of β-APCNs and adsorption of plasma proteins on β-APCNs...
February 27, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28239262/the-well-being-valuation-model-a-method-for-monetizing-the-nonmarket-good-of-individual-well-being
#16
James A Sidney, Ashlin Jones, Carter Coberley, James E Pope, Aaron Wells
The objective of this research is to advance the evaluation and monetization of well-being improvement programs, offered by population health management companies, by presenting a novel method that robustly monetizes the entirety of well-being improvement within a population. This was achieved by utilizing two employers' well-being assessments with medical and pharmacy administrative claims (2010-2011) across a large national employer (n = 50,647) and regional employer (n = 6170) data sets. This retrospective study sought to monetize both direct and indirect value of well-being improvement across a population whose medical costs are covered by an employer, insurer, and/or government entity...
2017: Health Services & Outcomes Research Methodology
https://www.readbyqxmd.com/read/28239254/adaptive-interventions-and-smart-designs-application-to-child-behavior-research-in-a-community-setting
#17
Kelley M Kidwell, Luke W Hyde
Heterogeneity between and within people necessitates the need for sequential personalized interventions to optimize individual outcomes. Personalized or adaptive interventions (AIs) are relevant for diseases and maladaptive behavioral trajectories when one intervention is not curative and success of a subsequent intervention may depend on individual characteristics or response. AIs may be applied to medical settings and to investigate best prevention, education, and community-based practices. AIs can begin with low-cost or low-burden interventions and followed with intensified or alternative interventions for those who need it most...
September 2016: American Journal of Evaluation
https://www.readbyqxmd.com/read/28238404/knowledge-of-asthma-and-anaphylaxis-among-teachers-in-spanish-schools
#18
J C Juliá-Benito, M Escarrer-Jaume, M T Guerra-Pérez, J Contreras-Porta, E Tauler-Toro, A Madroñero-Tentor, J C Cerdá-Mir
INTRODUCTION: Allergic diseases affect 15-20% of the paediatric population in the industrialised world. Most educational centres in Spain do not have health professionals among their staff, and the teachers are in charge of child care in school. The advisability of specific training of the teaching staff should be considered, with the introduction of concrete intervention plans in the event of life-threatening emergencies in schools. MATERIAL AND METHODS: Evaluation of the training needs constitutes the first step in planning an educational project...
February 18, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/28238143/electrospun-nanofiber-scaffolds-and-their-hydrogel-composites-for-the-engineering-and-regeneration-of-soft-tissues
#19
Ohan S Manoukian, Rita Matta, Justin Letendre, Paige Collins, Augustus D Mazzocca, Sangamesh G Kumbar
Electrospinning has emerged as a simple, elegant, and scalable technique that can be used to fabricate polymeric nanofibers. Pure polymers as well as blends and composites of both natural and synthetic ones have been successfully electrospun into nanofiber matrices for many biomedical applications. Tissue-engineered medical implants, such as polymeric nanofiber scaffolds, are potential alternatives to autografts and allografts, which are short in supply and carry risks of disease transmission. These scaffolds have been used to engineer various soft tissues, including connective tissues, such as skin, ligament, and tendon, as well as nonconnective ones, such as vascular, muscle, and neural tissue...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28238134/evaluating-nanoparticle-binding-to-blood-compartment-immune-cells-in-high-throughput-with-flow-cytometry
#20
Shann S Yu
Nanoparticles are increasingly being utilized for in vivo applications, where they are implemented as carriers for drugs, contrast agents for noninvasive medical imaging, or delivery vehicles for macromolecular agents such as DNA or proteins. However, they possess many physical and chemical properties that cause them to become rapidly recognized by the immune system as a foreign body, leading to their clearance and elimination, even before they may accumulate to critical concentrations at anatomic and cellular sites of action...
2017: Methods in Molecular Biology
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