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https://www.readbyqxmd.com/read/28830033/quartz-crystal-microbalance-sensing-cell-substrate-adhesion-and-beyond
#1
REVIEW
Jennifer Y Chen, Lynn S Penn, Jun Xi
Cell adhesion is an essential aspect of cellular behavior. Finding innovative methods to probe the adhesion of cells in their native state can greatly advance the understanding of control and regulation of cellular behavior and their impact on human health. The quartz crystal microbalance (QCM) is a label-free, biosensing system that has, in the past fifty years, evolved from a simple acoustic based mass sensor to a powerful bioanalytical tool. Its unique capability of monitoring the cell-substrate interaction non-invasively in real time has led to the emergence of its applications in areas that are relevant to fundamental cell biology and medical research...
August 15, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28830022/measurement-of-43-sc-and-44-sc-production-cross-section-with-an-18mev-medical-pet-cyclotron
#2
Tommaso Stefano Carzaniga, Martin Auger, Saverio Braccini, Maruta Bunka, Antonio Ereditato, Konrad Pawel Nesteruk, Paola Scampoli, Andreas Türler, Nicholas van der Meulen
(43)Sc and (44)Sc are positron emitter radionuclides that, in conjunction with the β(-) emitter (47)Sc, represent one of the most promising possibilities for theranostics in nuclear medicine. Their availability in suitable quantity and quality for medical applications is an open issue and their production with medical cyclotrons represents a scientific and technological challenge. For this purpose, an accurate knowledge of the production cross sections is mandatory. In this paper, we report on the cross section measurement of the reactions (43)Ca(p,n)(43)Sc, (44)Ca(p,2n) (43)Sc, (46)Ti(p,α)(43)Sc, and (44)Ca(p,n)(44)Sc at the Bern University Hospital cyclotron...
August 10, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28829995/factors-affecting-nursing-students-intention-to-report-medication-errors-an-application-of-the-theory-of-planned-behavior
#3
Merav Ben Natan, Ira Sharon, Marlen Mahajna, Sara Mahajna
BACKGROUND: Medication errors are common among nursing students. Nonetheless, these errors are often underreported. OBJECTIVES: To examine factors related to nursing students' intention to report medication errors, using the Theory of Planned Behavior, and to examine whether the theory is useful in predicting students' intention to report errors. DESIGN: This study has a descriptive cross-sectional design. SETTINGS: Study population was recruited in a university and a large nursing school in central and northern Israel...
August 15, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/28829650/user-acceptance-factors-of-hospital-information-systems-and-related-technologies-systematic-review
#4
Putu Wuri Handayani, Achmad Nizar Hidayanto, Indra Budi
This study reviews the literature on the most important acceptance factors associated with Hospital Information Systems (HIS) and related technologies based on user groups' perspectives (medical staff, hospital management, administrative personnel, patient, medical student, and IT staff), which can assist researchers and hospital management to develop suitable acceptance models to improve the quality of HIS. We conducted searches in online databases with large repositories of academic studies, written in English and fully accessible by the authors...
August 22, 2017: Informatics for Health & Social Care
https://www.readbyqxmd.com/read/28829524/a-comprehensive-clinical-review-of-opioid-induced-allodynia-discussion-of-the-current-evidence-and-clinical-implications
#5
Corey J Hayes, Jacob T Painter
Opioid analgesics are one of the most often prescribed medication classes, and their use has increased dramatically, with the number of prescriptions doubling between 1998 and 2010. Moreover, long-term use of opioids is becoming more prevalent. The complications arising from opioid use have been clearly documented; however, a relatively unknown complication potentially linked to opioid use is allodynia. This article outlines how research on opioid-induced hyperalgesia has led to the discovery of allodynia. Next, this article provides a detailed review of the current literature on allodynia, which includes animal studies, case reports, case series, and randomized controlled trials...
March 2017: Journal of Opioid Management
https://www.readbyqxmd.com/read/28829170/advanced-mri-techniques-of-the-shoulder-joint-current-applications-in-clinical-practice
#6
Christopher J Gottsegen, Alexander N Merkle, Jenny T Bencardino, Soterios Gyftopoulos
OBJECTIVE: We are fortunate to live in a time when real advances in medicine are happening at an increasingly rapid pace. This is especially true in the field of radiology, and keeping abreast of these advances is one of the main challenges of clinical practice. Traditionally, cutting edge techniques in our field have been researched and validated at major academic medical centers before slowly making their way into the armamentarium of routine clinical practice. However, the improved ability to communicate and disseminate information in our modern age has facilitated more rapid implementation of new techniques to allow us to better serve our patients...
September 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28828856/a-smart-self-assembled-organic-nanoprobe-for-protein-specific-detection-design-synthesis-application-and-mechanism-studies
#7
Tang Gao, Shuqi Yang, Xiaozheng Cao, Jie Dong, Ning Zhao, Peng Ge, Wenbin Zeng, Zhen Cheng
Specific detection or imaging protein has high potential to contribute greatly to medical diagnosis, biological research and therapeutic applications. The level of Human Serum Albumin (HSA) in blood is related to a variety of diseases and thus serves as an important biomarker for fast clinical diagnosis. Here we report the use of aggregation-induced emission (AIE) based supramolecular assembly to design biomolecular responsive smart organic nanomaterials for detection protein HSA. The designed nanoprobes were aggregates of small molecules and silent in fluorescence, but in the presence of HSA they disassembled and produced a clear turn-on fluorescent signal...
August 22, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28828667/an-adaptable-polyethylene-glycol-based-workflow-for-proteomic-analysis-of-extracellar-vesicles
#8
Stephanie N Hurwitz, David G Meckes
Extracellular vesicles (EVs), including exosomes are endocytically derived nanovesicles expelled from cells that contain molecular information in the form of lipids, proteins, and nucleic acids. Transfer of this information to other cells in local or distant microenvironments facilitates cell-to-cell communication. Importantly, diseased cells release exosomes containing specific cargo that may contribute to pathology and can be harnessed for diagnostic or prognostic use. The broad potential medical utility of exosomes has fueled rapidly expanding research on understanding the composition and functions of exosomes in normal and pathological conditions...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28828479/development-and-validation-of-a-tool-to-identify-patients-with-type-2-diabetes-at-high-risk-of-hypoglycemia-related-emergency-department-or-hospital-use
#9
Andrew J Karter, E Margaret Warton, Kasia J Lipska, James D Ralston, Howard H Moffet, Geoffrey G Jackson, Elbert S Huang, Donald R Miller
Importance: Hypoglycemia-related emergency department (ED) or hospital use among patients with type 2 diabetes (T2D) is clinically significant and possibly preventable. Objective: To develop and validate a tool to categorize risk of hypoglycemic-related utilization in patients with T2D. Design, Setting, and Participants: Using recursive partitioning with a split-sample design, we created a classification tree based on potential predictors of hypoglycemia-related ED or hospital use...
August 21, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28828316/the-application-of-collaborative-business-intelligence-technology-in-the-hospital-spd-logistics-management-model
#10
Tongzhu Liu, Aizong Shen, Xiaojian Hu, Guixian Tong, Wei Gu
BACKGROUND: We aimed to apply collaborative business intelligence (BI) system to hospital supply, processing and distribution (SPD) logistics management model. METHODS: We searched Engineering Village database, China National Knowledge Infrastructure (CNKI) and Google for articles (Published from 2011 to 2016), books, Web pages, etc., to understand SPD and BI related theories and recent research status. For the application of collaborative BI technology in the hospital SPD logistics management model, we realized this by leveraging data mining techniques to discover knowledge from complex data and collaborative techniques to improve the theories of business process...
June 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28828302/algorithm-based-arterial-blood-sampling-recognition-increasing-safety-in-point-of-care-diagnostics
#11
Jörg Peter, Wilfried Klingert, Kathrin Klingert, Karolin Thiel, Daniel Wulff, Alfred Königsrainer, Wolfgang Rosenstiel, Martin Schenk
AIM: To detect blood withdrawal for patients with arterial blood pressure monitoring to increase patient safety and provide better sample dating. METHODS: Blood pressure information obtained from a patient monitor was fed as a real-time data stream to an experimental medical framework. This framework was connected to an analytical application which observes changes in systolic, diastolic and mean pressure to determine anomalies in the continuous data stream. Detection was based on an increased mean blood pressure caused by the closing of the withdrawal three-way tap and an absence of systolic and diastolic measurements during this manipulation...
August 4, 2017: World Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28827239/validation-of-newly-developed-and-redesigned-key-indicator-methods-for-assessment-of-different-working-conditions-with-physical-workloads-based-on-mixed-methods-design-a-study-protocol
#12
Andre Klussmann, Falk Liebers, Felix Brandstädt, Marianne Schust, Patrick Serafin, Andreas Schäfer, Hansjürgen Gebhardt, Bernd Hartmann, Ulf Steinberg
INTRODUCTION: The impact of work-related musculoskeletal disorders is considerable. The assessment of work tasks with physical workloads is crucial to estimate the work-related health risks of exposed employees. Three key indicator methods are available for risk assessment regarding manual lifting, holding and carrying of loads; manual pulling and pushing of loads; and manual handling operations. Three further KIMs for risk assessment regarding whole-body forces, awkward body postures and body movement have been developed de novo...
August 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/28827221/leveraging-behavioral-economics-to-improve-heart-failure-care-and-outcomes
#13
REVIEW
Leslie L Chang, Adam D DeVore, Bradi B Granger, Zubin J Eapen, Dan Ariely, Adrian F Hernandez
Behavioral challenges are often present in human illness, so behavioral economics is increasingly being applied in healthcare settings to better understand why patients choose healthy or unhealthy behaviors. The application of behavioral economics to healthcare settings parallels recent shifts in policy and reimbursement structures that hold providers accountable for outcomes that are dependent on patient behaviors. Numerous studies have examined the application of behavioral economics principles to policy making and health behaviors, but there are limited data on applying these concepts to the management of chronic conditions, such as heart failure (HF)...
August 22, 2017: Circulation
https://www.readbyqxmd.com/read/28827211/development-and-deployment-of-the-openmrs-ebola-electronic-health-record-system-for-an-ebola-treatment-center-in-sierra-leone
#14
Shefali Oza, Darius Jazayeri, Jonathan M Teich, Ellen Ball, Patricia Alexandra Nankubuge, Job Rwebembera, Kevin Wing, Alieu Amara Sesay, Andrew S Kanter, Glauber D Ramos, David Walton, Rachael Cummings, Francesco Checchi, Hamish S Fraser
BACKGROUND: Stringent infection control requirements at Ebola treatment centers (ETCs), which are specialized facilities for isolating and treating Ebola patients, create substantial challenges for recording and reviewing patient information. During the 2014-2016 West African Ebola epidemic, paper-based data collection systems at ETCs compromised the quality, quantity, and confidentiality of patient data. Electronic health record (EHR) systems have the potential to address such problems, with benefits for patient care, surveillance, and research...
August 21, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28827079/application-of-genomics-for-transfusion-therapy-in-sickle-cell-anemia
#15
Stella T Chou, Connie M Westhoff
The application of genomic approaches is impacting all areas of laboratory testing including transfusion medicine. Use of DNA-based test methods is particularly applicable for red cell and platelet antigen typing as the majority of genes encoding the carrier proteins and carbohydrates are now known and were cloned in the 1990's. Many of the antigenic polymorphisms are due to single nucleotide changes (SNP's) in the respective genes and DNA-arrays that target these changes have been validated by comparison with conventional serologic typing...
August 8, 2017: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/28826886/risk-factors-for-fractures-identified-in-the-algorithm-developed-in-5-year-follow-up-of-postmenopausal-women-from-rac-ost-pol-study
#16
P Adamczyk, A Werner, M Bach, J Żywiec, A Czekajło, W Grzeszczak, B Drozdzowska, W Pluskiewicz
The aim of the study was to establish factors with an impact on fracture risk and to develop an algorithm to predict osteoporotic fracture. A total of 978 postmenopausal women from the epidemiological, population-based RAC-OST-POL study with a mean age of 65.7 ± 7.3 years were enrolled. At baseline, bone mineral density at hip and clinical risk factors for fracture were collected. Afterward, each person was asked annually on fracture incidence in the 5-year follow-up. Finally, data for complete 5-year observation were gathered for the group of 802 patients...
August 17, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28823022/long-term-bisphosphonate-therapy-in-osteogenesis-imperfecta
#17
REVIEW
A Biggin, C F Munns
PURPOSE OF REVIEW: Osteogenesis imperfecta (OI) is a genetic bone disorder resulting in bone fragility. It has a heterogeneous phenotype which typically includes reduced bone mass, multiple fractures, deformity, and chronic disability. Bisphosphonate treatment remains the first-line medical management, but there is still debate on aspects of its effectiveness. This review summarizes current knowledge about long-term bisphosphonate use in OI with recommendations on clinical application...
August 19, 2017: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/28822878/in-vitro-method-to-evaluate-the-barrier-properties-of-medical-devices-for-cutaneous-use
#18
Antonella Casiraghi, Francesco Ranzini, Umberto M Musazzi, Silvia Franzè, Marisa Meloni, Paola Minghetti
Barrier creams (BC) are marketed as cosmetic products or locally-applied medical devices to protect skin against damages induced by chemical agents or physical insults. However, the determination of the BC effectiveness is still a matter of discussion at both the clinical and the regulatory level. In this context, this work aimed at the development of a reliable, reproducible and easy-to-perform experimental protocol for the evaluation of BC performances. Preliminarily, an in vivo method based on the measurement of trans-epidermal water loss had been matter of investigation and was discarded: it required too much time and was not robust and sensitive enough...
August 16, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28822435/-characteristics-of-the-chinese-human-milk-banks-operation
#19
(no author information available yet)
Objective: To assess the operation status of human milk banks in the mainland of China. Method: This retrospective study included a consecutive series of 14 human milk banks in the mainland of China from March 2013 to December 2016. The opened date, condition of donated breast milk, characteristics of donors and clinical application of donated breast milk were analyzed. Result: There were 14 human milk banks successively founded in mainland China from March 2013 to December 2016. The number of human milk banks, the amount of donated breast milk, the number of eligible donors and the times of donation had increased each year...
August 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28822401/esophageal-perforation-a-common-clinical-problem-with-many-different-management-options
#20
Lloyd M Felmly, Hyejin Kwon, Chadrick E Denlinger, Jacob A Klapper
Esophageal perforation is a complex clinical entity that has multiple etiologies and variability in presentation, making it challenging to diagnose and treat. The mortality of esophageal perforation has improved because therapies have evolved. Whereas primary repair is the standard of care, multiple treatments may be employed successfully. We retrospectively reviewed all cases of suspected or confirmed esophageal perforation that were admitted to the thoracic surgery service at our institution between January 2011 and June 2016...
August 1, 2017: American Surgeon
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