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https://www.readbyqxmd.com/read/28522645/real-life-gh-dosing-patterns-in-children-with-ghd-ts-or-born-sga-a-report-from-the-nordinet%C3%A2-international-outcome-study
#1
Oliver Blankenstein, Marta Snajderova, Joanne C Blair, Effie Pournara, Birgitte Tønnes Pedersen, Isabelle Oliver Petit
OBJECTIVE: To describe real-life dosing patterns in children with growth hormone deficiency (GHD), born small for gestational age (SGA) or with Turner syndrome (TS) receiving growth hormone (GH) and enrolled in the NordiNet® International Outcome Study (IOS; NCT00960128) between 2006 and 2016. DESIGN: This non-interventional, multicentre study included paediatric patients diagnosed with GHD (isolated [IGHD] or multiple pituitary hormone deficiency [MPHD]), born SGA or with TS and treated according to everyday clinical practice from the Czech Republic (IGHD/MPHD/SGA/TS: n=425/61/316/119), France (n=1404/188/970/206), Germany (n=2603/351/1387/411) and the UK (n=259/60/87/35)...
May 18, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28510555/the-ios-11-to-do-list
#2
David Pogue
No abstract text is available yet for this article.
May 16, 2017: Scientific American
https://www.readbyqxmd.com/read/28503199/the-aachen-fall-prevention-app-a-smartphone-application-app-for-the-self-assessment-of-elderly-patients-at-risk-for-ground-level-falls
#3
Peter Rasche, Alexander Mertens, Christina Bröhl, Sabine Theis, Tobias Seinsch, Matthias Wille, Hans-Christoph Pape, Matthias Knobe
BACKGROUND: Fall incidents are a major problem for patients and healthcare. The "Aachen Fall Prevention App" (AFPA) represents the first mobile Health (mHealth) application (app) empowering older patients (persons 50+ years) to self-assess and monitor their individual fall risk. Self-assessment is based on the "Aachen Fall Prevention Scale," which consists of three steps. First, patients answer ten standardized yes-no questions (positive criterion ≥ 5 "Yes" responses). Second, a ten-second test of free standing without compensatory movement is performed (positive criterion: compensatory movement)...
2017: Patient Safety in Surgery
https://www.readbyqxmd.com/read/28497467/photoexam-adoption-of-an-ios-based-clinical-image-capture-application-at-mayo-clinic
#4
Kirk D Wyatt, Brian N Willaert, Peter J Pallagi, Richard A Uribe, James A Yiannias, Thomas R Hellmich
BACKGROUND: Mayo Clinic developed an internal iOS-based, point-of-care clinical image capture application for clinicians. We aimed to assess the adoption and utilization of the application at Mayo Clinic. METHODS: Metadata of 22,784 photos of 6417 patients taken by 606 users over 8040 clinical encounters between 3/1/2015 and 10/31/2015 were analyzed. A random sample of photos from 100 clinical encounters was assessed for quality using a five-item rubric. Use of traditional medical photography services before and after application launch were compared...
May 11, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28483744/etest-developing-a-smart-home-hiv-testing-kit-that-enables-active-real-time-follow-up-and-referral-after-testing
#5
Tyler Wray, Philip A Chan, Erik Simpanen, Don Operario
BACKGROUND: Men who have sex with men (MSM) are the group at highest risk for contracting human immunodeficiency virus (HIV) in the United States, but many do not test as frequently as recommended. Home-based self-testing (HBST) for HIV holds promise for promoting regular testing among these individuals, but currently available HBSTs have limited follow-up options, providing only a 1-800 number that participants can call. Failure to actively conduct follow-up counseling and referrals after HBST use could result in delays in seeking confirmatory testing and care among users receiving reactive (preliminary positive) test results...
May 8, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28480473/the-imia-history-working-group-inception-through-the-imia-history-taskforce-and-major-events-leading-up-to-the-50th-anniversary-of-imia
#6
C A Kulikowski, G Mihalas, R A Greenes, V Yacubsohn, H-A Park
BACKGROUND: The 50th Anniversary of IMIA will be celebrated in 2017 at the World Congress of Medical Informatics in China. This takes place 50 years after the International Federation of Information Processing (IFIP) Societies approved the formation of a new Technical Committee (TC) 4 on Medical Information Processing, which was the predecessor of IMIA, under the leadership of Dr. Francois Grémy. The IMIA History Working Group (WG) was approved in 2014 to document and write about the history of the field and its organizations...
May 8, 2017: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/28467473/users-of-the-main-smartphone-operating-systems-ios-android-differ-only-little-in-personality
#7
Friedrich M Götz, Stefan Stieger, Ulf-Dietrich Reips
The increasingly widespread use of mobile phone applications (apps) as research tools and cost-effective means of vast data collection raises new methodological challenges. In recent years, it has become a common practice for scientists to design apps that run only on a single operating system, thereby excluding large numbers of users who use a different operating system. However, empirical evidence investigating any selection biases that might result thereof is scarce. Henceforth, we conducted two studies drawing from a large multi-national (Study 1; N = 1,081) and a German-speaking sample (Study 2; N = 2,438)...
2017: PloS One
https://www.readbyqxmd.com/read/28459556/pred-skin-a-fast-and-reliable-web-application-to-assess-skin-sensitization-effect-of-chemicals
#8
Rodolpho C Braga, Vinicius M Alves, Eugene N Muratov, Judy Strickland, Nicole Kleinstreuer, Alexander Trospsha, Carolina Horta Andrade
Chemically induced skin sensitization is a complex immunological disease with a profound impact on quality of life and working ability. Despite some progress in developing alternative methods for assessing the skin sensitization potential of chemical substances, there is no in vitro test that correlates well with human data. Computational QSAR models provide a rapid screening approach and contribute valuable information for the assessment of chemical toxicity. We describe the development of a freely accessible web-based and mobile application for the identification of potential skin sensitizers...
May 10, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28453578/effects-of-a-mixture-of-chloromethylisothiazolinone-and-methylisothiazolinone-on-peripheral-airway-dysfunction-in-children
#9
Hyun-Ju Cho, Dong-Uk Park, Jisun Yoon, Eun Lee, Song-I Yang, Young-Ho Kim, So-Yeon Lee, Soo-Jong Hong
BACKGROUND: Children who were only exposed to a mixture of chloromethylisothiazolinone (CMIT) and methylisothiazolinone (MIT) as humidifier disinfectant (HD) components were evaluated for humidifier disinfectant-associated lung injury (HDLI) from 2012. This study was to evaluate the pulmonary function using, impulse oscillometry (IOS) for children exposed to a mixture of CMIT/MIT from HD. METHODS: Twenty-four children who were only exposed to a mixture of CMIT/MIT, with no previous underlying disease, were assessed by IOS...
2017: PloS One
https://www.readbyqxmd.com/read/28452236/mobile-access-to-virtual-randomization-for-investigator-initiated-trials
#10
Thomas M Deserno, András P Keszei
Background/aims Randomization is indispensable in clinical trials in order to provide unbiased treatment allocation and a valid statistical inference. Improper handling of allocation lists can be avoided using central systems, for example, human-based services. However, central systems are unaffordable for investigator-initiated trials and might be inaccessible from some places, where study subjects need allocations. We propose mobile access to virtual randomization, where the randomization lists are non-existent and the appropriate allocation is computed on demand...
April 1, 2017: Clinical Trials: Journal of the Society for Clinical Trials
https://www.readbyqxmd.com/read/28439206/is-operavox-a-clinically-useful-tool-for-the-assessment-of-voice-in-a-general-ent-clinic
#11
Richard Teck Kee Siau, Jay Goswamy, Sue Jones, Sadie Khwaja
BACKGROUND: Objective acoustic analysis is a key component of multidimensional voice assessment. OperaVOX is an iOS app which has been shown to be comparable to Multi Dimensional Voice Program for most principal measures of vocal function. As a relatively cheap, portable and easily accessible form of acoustic analysis, OperaVOX may be more clinically useful than laboratory-based software in many situations. This study aims to determine whether correlation exists between acoustic measurements obtained using OperaVOX, and perceptual evaluation of voice...
2017: BMC Ear, Nose, and Throat Disorders
https://www.readbyqxmd.com/read/28418753/intraosseous-pressure-monitoring-in-healthy-volunteers
#12
Joshua G Salzman, Nicholas M Loken, Sandi S Wewerka, Aaron M Burnett, Abigail E Zagar, Kent R Griffith, Peter L Bliss, Bjorn K Peterson, Christopher J Ward, Ralph J Frascone
STUDY OBJECTIVE: Invasively monitoring blood pressure through the IO device has not been thoroughly demonstrated. This study attempted to establish baseline values of IO pressure in a healthy human population. METHODS: This was a prospective, healthy volunteer, observational study. Participants had two IO devices placed (humerus and tibia), and participant IO pressures, vital signs, and pain scores were monitored for up to 60 minutes. Participants were contacted at 24-hours and 7 days post-testing to assess for adverse events...
April 18, 2017: Prehospital Emergency Care
https://www.readbyqxmd.com/read/28410180/rotterdam-prostate-cancer-risk-calculator-development-and-usability-testing-of-the-mobile-phone-app
#13
Nuno Pereira-Azevedo, Luís Osório, Avelino Fraga, Monique J Roobol
BACKGROUND: The use of prostate cancer screening tools that take into account relevant prebiopsy information (ie, risk calculators) is recommended as a way of determining the risk of cancer and the subsequent need for a prostate biopsy. This has the potential to limit prostate cancer overdiagnosis and subsequent overtreatment. mHealth apps are gaining traction in urological practice and are used by both practitioners and patients for a variety of purposes. OBJECTIVE: The impetus of the study was to design, develop, and assess a smartphone app for prostate cancer screening, based on the Rotterdam Prostate Cancer Risk Calculator (RPCRC)...
January 6, 2017: JMIR Cancer
https://www.readbyqxmd.com/read/28397998/determinants-of-peripheral-airway-function-in-adults-with-and-without-asthma
#14
Paul D Robinson, Gregory G King, Malcolm R Sears, Chuen Y Hong, Robert J Hancox
BACKGROUND AND OBJECTIVE: Peripheral airway involvement in asthma remains poorly understood. We investigated impulse oscillometry (IOS) measures of peripheral airway function in a population-based birth cohort. METHODS: Pre- and post-bronchodilator spirometry and IOS measures of respiratory resistance and reactance were measured in 915 participants at age 38 years. RESULTS: Current asthma was associated with impairments in both spirometry and IOS parameters...
April 11, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28370697/-selecting-appraising-recommending-and-using-mobile-applications-apps-in-nursing
#15
EDITORIAL
Caleb Ferguson, Debra Jackson
It's more than likely that a patient, their family member or a colleague may have recently asked you "Is there an app for that?" Mobile technology is inescapable. It is pervasive in almost every aspect of daily life. Wherever we look, people are often hunched over and fully immersed by a small 6 x 3 inch screen, whether it be walking on the street, travelling on the bus, at the coffee shop or in the clinic waiting room. Mobile devices have infiltrated most aspects of our lives and offer quick, adaptive tech-based solutions to many previously administrative, repetitive or otherwise time-consuming tasks...
March 31, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28370444/the-icatibant-outcome-survey-experience-of-hereditary-angioedema-management-from-six-european-countries
#16
T Caballero, W Aberer, H J Longhurst, M Maurer, A Zanichelli, A Perrin, L Bouillet, I Andresen
BACKGROUND: Hereditary angioedema (HAE) due to C1 INH deficiency (C1-INH-HAE) is a rare, potentially fatal, bradykinin-mediated disease. Icatibant is a bradykinin B2 receptor antagonist originally approved in 2008 in the European Union and 2011 in the United States, as an acute therapy option for HAE attacks in adults. OBJECTIVE: To compare demographics, disease characteristics and treatment outcomes of icatibant-treated HAE attacks in patients with C1-INH-HAE enrolled in the Icatibant Outcome Survey across six European countries: Austria, France, Germany, Italy, Spain and the United Kingdom...
April 1, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28364359/mhealth-app-for-ios-to-help-in-diagnostic-decision-in-ophthalmology-to-primary-care-physicians
#17
Marta Manovel López, Miguel Maldonado López, Isabel de la Torre Díez, José Carlos Pastor Jimeno, Miguel López-Coronado
Decision support systems (DSS) are increasingly demanded due that diagnosis is one of the main activities that physicians accomplish every day. This fact seems critical when primary care physicians deal with uncommon problems belonging to specialized areas. The main objective of this paper is the development and user evaluation of a mobile DSS for iOS named OphthalDSS. This app has as purpose helping in anterior segment ocular diseases' diagnosis, besides offering educative content about ophthalmic diseases to users...
May 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28364283/lisbon-emoji-and-emoticon-database-leed-norms-for-emoji-and-emoticons-in-seven-evaluative-dimensions
#18
David Rodrigues, Marília Prada, Rui Gaspar, Margarida V Garrido, Diniz Lopes
The use of emoticons and emoji is increasingly popular across a variety of new platforms of online communication. They have also become popular as stimulus materials in scientific research. However, the assumption that emoji/emoticon users' interpretations always correspond to the developers'/researchers' intended meanings might be misleading. This article presents subjective norms of emoji and emoticons provided by everyday users. The Lisbon Emoji and Emoticon Database (LEED) comprises 238 stimuli: 85 emoticons and 153 emoji (collected from iOS, Android, Facebook, and Emojipedia)...
March 31, 2017: Behavior Research Methods
https://www.readbyqxmd.com/read/28352170/clinical-application-value-of-impulse-oscillometry-in-geriatric-patients-with-copd
#19
Zhonghui Liu, Lianjun Lin, Xinmin Liu
BACKGROUND: The diagnosis and assessment of COPD rely mainly on the use of spirometry, which is an effort-dependent test and requires good patient cooperation. Impulse oscillometry (IOS) is a non-volitional method that requires less effort and cooperation and presents advantages for geriatric patients. However, the clinical application value of IOS in geriatric patients with COPD remains unclear. AIM: The aim of this study was to investigate the clinical application value of IOS in geriatric patients with COPD...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28350997/synthesis-and-biological-evaluation-of-hypoxia-activated-prodrugs-of-sn-38
#20
Chen Jin, Qiumeng Zhang, Wei Lu
We designed new hypoxia-activated prodrugs by conjugating (1-methyl-2-nitro-1H-imidazol-5-yl)methanol with 7-ethyl-10-hydroxy camptothecin (SN-38). Initially, we improved the method of multi-gram scale synthesis of (1-methyl-2-nitro-1H-imidazol-5-yl)methanol, which increased the yield to 42% compared to 8% by the original synthesis method. The improved method was used to synthesize evofosfamide (TH-302) and hypoxia-activated prodrugs of SN-38. Two different linkages between (1-methyl-2-nitro-1H-imidazol-5-yl)methanol and SN-38 were evaluated that afforded different hypoxia-selectivity and toxicity...
March 22, 2017: European Journal of Medicinal Chemistry
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