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https://www.readbyqxmd.com/read/28350997/synthesis-and-biological-evaluation-of-hypoxia-activated-prodrugs-of-sn-38
#1
Chen Jin, Qiumeng Zhang, Wei Lu
We designed new hypoxia-activated prodrugs by conjugating (1-methyl-2-nitro-1H-imidazol-5-yl)methanol with 7-ethyl-10-hydroxy camptothecin (SN-38). Initially, we improved the method of multi-gram scale synthesis of (1-methyl-2-nitro-1H-imidazol-5-yl)methanol, which increased the yield to 42% compared to 8% by the original synthesis method. The improved method was used to synthesize evofosfamide (TH-302) and hypoxia-activated prodrugs of SN-38. Two different linkages between (1-methyl-2-nitro-1H-imidazol-5-yl)methanol and SN-38 were evaluated that afforded different hypoxia-selectivity and toxicity...
March 22, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28339974/redcap-ios-and-researchkit-integration-for-clinical-decision-support
#2
Christopher Metts
No abstract text is available yet for this article.
March 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28321440/neuronify-an-educational-simulator-for-neural-circuits
#3
Svenn-Arne Dragly, Milad Hobbi Mobarhan, Andreas Våvang Solbrå, Simen Tennøe, Anders Hafreager, Anders Malthe-Sørenssen, Marianne Fyhn, Torkel Hafting, Gaute T Einevoll
Educational software (apps) can improve science education by providing an interactive way of learning about complicated topics that are hard to explain with text and static illustrations. However, few educational apps are available for simulation of neural networks. Here, we describe an educational app, Neuronify, allowing the user to easily create and explore neural networks in a plug-and-play simulation environment. The user can pick network elements with adjustable parameters from a menu, i.e., synaptically connected neurons modelled as integrate-and-fire neurons and various stimulators (current sources, spike generators, visual, and touch) and recording devices (voltmeter, spike detector, and loudspeaker)...
March 2017: ENeuro
https://www.readbyqxmd.com/read/28300972/a-review-of-smartphone-apps-for-smoking-cessation-available-in-portuguese
#4
Taynara Dutra Batista Formagini, Rafaela Russi Ervilha, Nathália Munck Machado, Bárbara Any Bianchi Bottaro de Andrade, Henrique Pinto Gomide, Telmo Mota Ronzani
Smartphone apps are being developed as a complement to smoking cessation treatment. The current study aimed to analyze the content of available apps in Portuguese in two operational systems, Android and iOS. Fifty-one apps were found in iTunes and 600 in Google Play. Content evaluation included apps that focused on smoking cessation, with a total of 12 apps in iOS and 3 in Android. Each app was categorized according to its approach to smoking cessation and scored according to level of adherence to the Treating Tobacco Use and Dependence smoking cessation treatment guideline...
March 9, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/28295580/specpad-device-independent-nmr-data-visualization-and-processing-based-on-the-novel-dart-programming-language-and-html5-web-technology
#5
Bruno Guigas
SpecPad is a new device-independent software program for the visualization and processing of one- and two-dimensional NMR time domain (FID) and frequency domain (spectrum) data. It is the result of a project to investigate whether the novel programming language DART, in combination with Html5 Web technology, forms a suitable base to write an NMR data evaluation software which runs on modern computing devices such as Android, iOS, and Windows tablets as well as on Windows, Linux, and Mac OS X desktop PCs and notebooks...
March 12, 2017: Magnetic Resonance in Chemistry: MRC
https://www.readbyqxmd.com/read/28293621/development-of-the-physical-activity-and-your-nutrition-for-cancer-pync-smartphone-app-for-preventing-breast-cancer-in-women
#6
Steven S Coughlin, Gina M Besenyi, Deborah Bowen, Gianluca De Leo
BACKGROUND: In the U.S., breast cancer accounts for more cancer deaths in women than any site other than lung cancer. Based upon attributable risks, about 30-35% of breast cancers could potentially be prevented by addressing obesity, physical inactivity, increased alcohol consumption, and carcinogenic exposures such as hormone replacement therapy (HRT). We need methods of reducing women's risks of this disease that are attractive and easy to use, widely accessible to diverse women, and able to be easily amended to account for new research...
2017: MHealth
https://www.readbyqxmd.com/read/28293619/the-fitness-of-apps-a-theory-based-examination-of-mobile-fitness-app-usage-over-5-months
#7
Lynn Katherine Herrmann, Jinsook Kim
BACKGROUND: There are thousands of fitness-related smartphone applications ("apps") available for free and purchase, but there is uncertainty if these apps help individuals achieve and maintain personal fitness. Technology usage attrition is also a concern among research studies on health technologies. METHODS: Usage of three fitness apps was examined over 5 months to assess adherence and effectiveness. Initially, 64 participants downloaded three free apps available on Android and iOS and 47 remained in the study until posttest...
2017: MHealth
https://www.readbyqxmd.com/read/28286821/smartphones-and-medical-applications-in-the-emergency-department-daily-practice
#8
Amirhosein Jahanshir, Ehsan Karimialavijeh, Hojjat Sheikh, Motahar Vahedi, Mehdi Momeni
INTRODUCTION: Medical applications help physicians to make more rapid and evidence based decisions that may provide better patient care. This study aimed to determine the extent to which smart phones and medical applications are integrated in the emergency department daily practice. METHOD: In a cross sectional study, a modified standard questionnaire (Payne et al.) consisting of demographic data and information regarding quality and quantity of smartphone and medical app utilization was sent to emergency-medicine residents and interns twice (two weeks apart), in January 2015...
2017: Emergency (Tehran, Iran)
https://www.readbyqxmd.com/read/28286761/developing-an-app-by-exploiting-web-based-mobile-technology-to-inspect-controlled-substances-in-patient-care-units
#9
Ying-Hao Lu, Li-Yao Lee, Ying-Lan Chen, Hsing-I Cheng, Wen-Tsung Tsai, Chen-Chun Kuo, Chung-Yu Chen, Yaw-Bin Huang
We selected iOS in this study as the App operation system, Objective-C as the programming language, and Oracle as the database to develop an App to inspect controlled substances in patient care units. Using a web-enabled smartphone, pharmacist inspection can be performed on site and the inspection result can be directly recorded into HIS through the Internet, so human error of data translation can be minimized and the work efficiency and data processing can be improved. This system not only is fast and convenient compared to the conventional paperwork, but also provides data security and accuracy...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28286594/locking-it-down-the-privacy-and-security-of-mobile-medication-apps
#10
Kelly Grindrod, Jonathan Boersema, Khrystine Waked, Vivian Smith, Jilan Yang, Catherine Gebotys
OBJECTIVE: To explore the privacy and security of free medication applications (apps) available to Canadian consumers. METHODS: The authors searched the Canadian iTunes store for iOS apps and the Canadian Google Play store for Android apps related to medication use and management. Using an Apple iPad Air 2 and a Google Nexus 7 tablet, 2 reviewers generated a list of apps that met the following inclusion criteria: free, available in English, intended for consumer use and related to medication management...
January 2017: Canadian Pharmacists Journal: CPJ, Revue des Pharmaciens du Canada: RPC
https://www.readbyqxmd.com/read/28274467/an-iphone-application-for-upper-arm-posture-and-movement-measurements
#11
Liyun Yang, Wilhelmus J A Grooten, Mikael Forsman
There is a need for objective methods for upper arm elevation measurements for accurate and convenient risk assessments. The aims of this study were (i) to compare a newly developed iOS application (iOS) for measuring upper arm elevation and angular velocity with a reference optical tracking system (OTS), and (ii) to compare the accuracy of the iOS incorporating a gyroscope and an accelerometer with using only an accelerometer, which is standard for inclinometry. The iOS-OTS limits of agreement for static postures (9 subjects) were -4...
March 6, 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/28269256/telemedicine-with-mobile-devices-and-augmented-reality-for-early-postoperative-care
#12
Brent A Ponce, Eugene W Brabston, Shin Zu, Shawna L Watson, Dustin Baker, Dennis Winn, Barton L Guthrie, Mahesh B Shenai
Advanced features are being added to telemedicine paradigms to enhance usability and usefulness. Virtual Interactive Presence (VIP) is a technology that allows a surgeon and patient to interact in a "merged reality" space, to facilitate both verbal, visual, and manual interaction. In this clinical study, a mobile VIP iOS application was introduced into routine post-operative orthopedic and neurosurgical care. Survey responses endorse the usefulness of this tool, as it relates to The virtual interaction provides needed virtual follow-up in instances where in-person follow-up may be limited, and enhances the subjective patient experience...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268850/anticoagulation-manager-development-of-a-clinical-decision-support-mobile-application-for-management-of-anticoagulants
#13
Chih-Wen Cheng, Hang Wu, Pamela J Thompson, Julie R Taylor, Barbara A Zehnbauer, Karlyn K Wilson, May D Wang
Patients with certain clotting disorders or conditions have a greater risk of developing arterial or venous clots and downstream embolisms, strokes, and arterial insufficiency. These patients need prescription anticoagulant drugs to reduce the possibility of clot formation. However, historically, the clinical decision making workflow in determining the correct type and dosage of anticoagulant(s) is part science and part art. To address this problem, we developed Anticoagulation Manager, an intelligent clinical decision workflow management system on iOS-based mobile devices to help clinicians effectively choose the most appropriate and helpful follow-up clotting tests for patients with a common clotting profile...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28263408/cultural-competency-of-a-mobile-customized-patient-education-tool-for-improving-potential-kidney-transplant-recipients-knowledge-and-decision-making
#14
David A Axelrod, Crystal S Kynard-Amerson, David Wojciechowski, Marie Jacobs, Krista L Lentine, Mark Schnitzler, John D Peipert, Amy D Waterman
Patients considering renal transplantation face an increasingly complex array of choices as a result of the revised kidney transplant allocation system. Decision aids have been shown to improve patient decision making through the provision of detailed, relevant, individualized clinical data. A mobile iOS based application (app) including animated patient education and individualized risk adjusted outcomes following kidney transplants with varying donor characteristics and DSA waiting times was piloted in 2 large US transplant programs with a diverse group of renal transplant candidates (N=81)...
March 6, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28259974/3-hydroxyterphenyllin-a-natural-fungal-metabolite-induces-apoptosis-and-s-phase-arrest-in-human-ovarian-carcinoma-cells
#15
Yaomin Wang, Casey Compton, Gary O Rankin, Stephen J Cutler, Yon Rojanasakul, Youying Tu, Yi Charlie Chen
In the present study, we evaluated 3-Hydroxyter-phenyllin (3-HT) as a potential anticancer agent using the human ovarian cancer cells A2780/CP70 and OVCAR-3, and normal human epithelial ovarian cells IOSE-364 as an in vitro model. 3-HT suppressed proliferation and caused cytotoxicity against A2780/CP70 and OVCAR-3 cells, while it exhibited lower cytotoxicity in IOSE-364 cells. Subsequently, we found that 3-HT induced S phase arrest and apoptosis in a dose-independent manner. Further investigation revealed that S phase arrest was related with DNA damage which mediated the ATM/p53/Chk2 pathway...
March 2, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28250922/hereditary-angioedema-with-normal-c1-inhibitor-in-a-french-cohort-clinical-characteristics-and-response-to-treatment-with-icatibant
#16
Laurence Bouillet, Isabelle Boccon-Gibod, David Launay, Anne Gompel, Gisele Kanny, Vincent Fabien, Oliver Fain
INTRODUCTION: The clinical characteristics and icatibant-treatment outcomes of patients with hereditary angioedema with normal C1 inhibitor (HAE-nC1 INH) are limited. METHODS: We retrospectively analyzed data from French HAE patients enrolled in the Icatibant Outcome Survey registry (from July 2009 to September 2013) to compare disease characteristics and the effectiveness and safety of acute icatibant-treated angioedema attacks in patients with HAE-nC1 INH, HAE with C1 INH deficiency (type I), or dysfunction (type II)...
March 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/28246069/-back-on-track-a-mobile-app-observational-study-using-apple-s-researchkit-framework
#17
Martin Zens, Peter Woias, Norbert P Suedkamp, Philipp Niemeyer
BACKGROUND: In March 2015, Apple Inc announced ResearchKit, a novel open-source framework intended to help medical researchers to easily create apps for medical studies. With the announcement of this framework, Apple presented 5 apps built in a beta phase based on this framework. OBJECTIVE: The objective of this study was to better understand decision making in patients with acute anterior cruciate ligament (ACL) ruptures. Here, we describe the development of a ResearchKit app for this study...
February 28, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28243070/improving-adherence-and-outcomes-in-diabetic-patients
#18
Renu Joshi, Disha Joshi, Pramil Cheriyath
OBJECTIVE: Nonadherence in diabetes is a problem leading to wasted resources and preventable deaths each year. Remedies for diminishing nonadherence are many but marginally effective, and outcomes remain suboptimal. AIM: The aim of this study was to test a new iOS "app", PatientPartner. Derived from complexity theory, this novel technology has been extensively used in other fields; this is the first trial in a patient population. METHODS: Physicians referred patients who were "severely non-adherent" with HbA1c levels >8...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28240502/smartphone-smart-surgeon-what-about-a-smart-logbook
#19
A Adam, K Spencer, S Moon, I Jacub
BACKGROUND: Mobile phone applications (Apps) have become a vital assistant to medical personnel in today's technologically advanced era. The utility of Apps with case logbook capabilities has not yet been explored. OBJECTIVE: To assess and evaluate all currently available surgical and procedural case logbook Apps. METHOD: A comprehensive search was conducted in April 2015 on the Android Play Store, iTunes (Apple App Store, iOS), and BlackBerry World for surgical and/or procedural logbooks...
June 2016: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28231346/in-vitro-three-dimensional-accuracy-of-digital-implant-impressions-the-effect-of-implant-angulation
#20
Vanessa A Chia, Roxanna J Esguerra, Khim Hean Teoh, Juin Wei Teo, Keng Mun Wong, Keson B Tan
PURPOSE: To compare the three-dimensional (3D) accuracy of conventional impressions (CIs) with digital scans (DSs) using an intraoral scanner (IOS) with intraoral scan bodies (SBs) and varying buccolingual interimplant angulations. A secondary aim was to measure the SB machining tolerance and height with and without application of torque. MATERIALS AND METHODS: Three master models (MMs) with two implants simulating an implant-supported three-unit fixed partial denture for bone-level implants were used...
March 2017: International Journal of Oral & Maxillofacial Implants
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