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Visceral pain

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https://www.readbyqxmd.com/read/28930716/antinociceptive-effect-of-ghrelin-in-a-rat-model-of-irritable-bowel-syndrome-involves-trpv1-opioid-systems
#1
Yuqing Mao, Zhengyang Li, Kan Chen, Huafang Yu, Shaoren Zhang, Miao Jiang, Yuanhua Ma, Chunli Liang, Hongyan Liu, Huanqing Li, Qian Hua, Hao Zhou, Yonghong Sun, Xiaoming Fan
BACKGROUND/AIMS: Irritable bowel syndrome (IBS), defined as recurrent abdominal pain and changes in bowel habits, seriously affects quality of life and ability to work. Ghrelin is a brain-gut hormone, which has been reported to show antinociceptive effects in peripheral pain. We investigated the effect of ghrelin on visceral hypersensitivity and pain in a rat model of IBS. METHODS: Maternal deprivation (MD) was used to provide a stress-induced model of IBS in Wistar rats...
September 20, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28918297/a-rare-case-of-spontaneous-rupture-of-an-aneurysm-of-the-right-gastric-artery
#2
Yu-Ki Takemoto, Nobuaki Fujikuni, Kazuaki Tanabe, Hironobu Amano, Toshio Noriyuki, Masahiro Nakahara
BACKGROUND: Visceral artery aneurysms at the origin of the gastric and gastroepiploic artery are uncommon. Raptured visceral aneurysms cause high mortality and require urgent and adequate intervention and treatment. PRESENTATION OF CASE: A 65-year-old woman was transferred to the emergency department with sudden abdominal and back pain. Radiographically, we diagnosed intra-abdominal bleeding due to a ruptured aneurysm of the right gastric artery. Although her vital signs were relatively stable, transcatheter arterial embolization (TAE) could not be performed due to thrombotic occlusion of her abdominal aorta, and bilateral axillary arteries...
September 1, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28898282/p2x3-receptor-involvement-in-endometriosis-pain-via-erk-signaling-pathway
#3
Shaojie Ding, Libo Zhu, Yonghong Tian, Tianhong Zhu, Xiufeng Huang, Xinmei Zhang
The purinergic receptor P2X ligand-gated ion channel 3 (P2X3) is crucially involved in peripheral nociceptive processes of somatic and visceral pain. Endometriosis pain is considered as a kind of inflammatory and neuropathic pain. However, whether P2X3 is involved in endometriosis pain has not been reported up to date. Here, we aimed to determine whether P2X3 expression in endometriotic lesions is involved in endometriosis pain, which is regulated by inflammatory mediators through extracellular regulated protein kinases (ERK) signalling pathway...
2017: PloS One
https://www.readbyqxmd.com/read/28893013/effects-of-intraperitoneal-local-anaesthetics-bupivacaine-and-ropivacaine-versus-placebo-on-postoperative-pain-after-laparoscopic-cholecystectomy-a-randomised-double-blind-study
#4
Neha T Das, Charulata Deshpande
INTRODUCTION: Laparoscopic Cholecystectomy (LC) is the most frequently performed elective daycare surgery and provision of postoperative pain relief is of importance. After laparoscopic cholecystectomy shoulder and abdominal pain causes considerable distress. Visceral pain during coughing, respiration and mobilization increases morbidity, hospital stay and costs. AIM: To compare the analgesic efficacy of intraperitoneally instilled equipotent concentrations of bupivacaine and ropivacaine versus placebo in relieving postoperative pain after laparoscopic cholecystectomy when used as a part of multimodal analgesia...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28891374/spontaneous-dissection-of-the-celiac-artery-in-the-young-a-case-report-and-literature-review
#5
Marco Tana, Claudio Tana, Cosima Schiavone, Valerio Verdiani, Carlo Palermo, Massimo Alessandri, Maria Adele Giamberardino, Andrea Montagnani
Introduction The spontaneous isolated celiac artery dissection (siCAD) represents a challenging cause of abdominal pain and complete information regarding incidence, etiology and risk factors in the young is still lacking. In this study, we report a case of siCAD occurred in a young woman and we systematically searched for information on siCADs in literature databases. Methods PubMed/Embase and Cochrane were searched for, using the following terms: Isolated celiac trunk dissection, isolated celiac artery dissection, celiac artery dissection, celiac trunk dissection, spontaneous isolated visceral artery dissection, spontaneous isolated dissection of visceral arteries, isolated celiac artery dissection in the young, isolated celiac trunk dissection in the young...
September 11, 2017: Hospital Practice (Minneapolis)
https://www.readbyqxmd.com/read/28886046/effects-of-water-avoidance-stress-on-peripheral-and-central-responses-during-bladder-filling-in-the-rat-a-multidisciplinary-approach-to-the-study-of-urologic-chronic-pelvic-pain-syndrome-mapp-research-network-study
#6
Zhuo Wang, Harriet H Chang, Yunliang Gao, Rong Zhang, Yumei Guo, Daniel P Holschneider, Larissa V Rodriguez
Stress plays a role in the exacerbation and possibly the development of functional lower urinary tract disorders. Chronic water avoidance stress (WAS) in rodents is a model with high construct and face validity to bladder hypersensitive syndromes, such as interstitial cystitis/bladder pain syndrome (IC/BPS), characterized by urinary frequency and bladder hyperalgesia and heightened stress responsiveness. Given the overlap of the brain circuits involved in stress, anxiety, and micturition, we evaluated the effects chronic stress has on bladder function, as well as its effects on regional brain activation during bladder filling...
2017: PloS One
https://www.readbyqxmd.com/read/28885452/mirna-mediated-downregulation-of-kcc2-and-vgat-expression-in-spinal-cord-contributes-to-neonatal-cystitis-induced-visceral-pain-in-rats
#7
Jian Zhang, James Yu, Pradeep Kannampalli, Linghui Nie, Hui Meng, Bidyut Medda, Reza Shaker, Jyoti N Sengupta, Banani Banerjee
Loss of GABAergic inhibition in pain pathways has been considered to be a key component in the development of chronic pain. In the present study, we intended to examine if miR-92b-mediated post-transcriptional dysregulation of spinal potassium chloride cotransporter (KCC2) and vesicular GABA transporter (VGAT) plays a major role in the development and maintenance of long-term visceral hyperalgesia in neonatal zymosan-treated rats. Neonatal cystitis was induced by transurethral zymosan administration from postnatal (P) days 14-16 (protocol 1)...
September 1, 2017: Pain
https://www.readbyqxmd.com/read/28884838/review-article-transient-receptor-potential-channels-as-possible-therapeutic-targets-in-irritable-bowel-syndrome
#8
REVIEW
A B Beckers, Z Z R M Weerts, Z Helyes, A A M Masclee, D Keszthelyi
BACKGROUND: Abdominal pain in irritable bowel syndrome (IBS) remains challenging to treat effectively. Researchers have attempted to elucidate visceral nociceptive processes in order to guide treatment development. Transient receptor potential (TRP) channels have been implied in the generation (TRPV1, TRPV4, TRPA1) and inhibition (TRPM8) of visceral pain signals. Pathological changes in their functioning have been demonstrated in inflammatory conditions, and appear to be present in IBS as well...
September 8, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28874926/craniosacral-therapy-and-visceral-manipulation-a-new-treatment-intervention-for-concussion-recovery
#9
Gail Wetzler, Melinda Roland, Sally Fryer-Dietz, Dee Dettmann-Ahern
Background: Military service members and veterans face health issues related to traumatic brain injury (TBI), especially during combat, use of heavy equipment, and exposures to environmental hazards and explosives. There were 400,000 TBIs reported in deployed U.S. troops in 2012. Athletes are also subject to TBI. Studies have indicated that some manual therapies could be helpful for treating patients who have post-concussive syndrome. Objective: This case series report describes the effects of CranioSacral Therapy (CST), Visceral Manipulation (VM), and Neural Manipulation (NM) modalities for treating patients who have post-concussion syndrome...
August 1, 2017: Medical Acupuncture
https://www.readbyqxmd.com/read/28867481/lesions-of-the-central-amygdala-and-ventromedial-medulla-reduce-bladder-hypersensitivity-produced-by-acute-but-not-chronic-foot-shock
#10
Alan Randich, Cary DeWitte, Jennifer J DeBerry, Meredith T Robbins, Timothy J Ness
Both acute and chronic stress has been shown to exacerbate symptoms of chronic visceral pain conditions such as interstitial cystitis. Studies using animal models support these findings in that both acute and chronic exposure to foot shock-induced stress (FS) augment nociceptive reflex responses to urinary bladder distension (UBD). Only a few studies have examined the neural substrates mediating these phenomena and it is not clear whether acute and chronic stress engage the same or different substrates to produce bladder hypersensitivity...
August 31, 2017: Brain Research
https://www.readbyqxmd.com/read/28861709/a-nociceptive-stress-model-of-adolescent-physical-abuse-induces-contextual-fear-and-cingulate-nociceptive-neuroplasticities
#11
Brent A Vogt, Leslie J Vogt, Robert W Sikes
Adolescent physical abuse impairs emotional development and evokes cingulate pathologies, but its neuronal and circuit substrates are unknown. Conditioning adolescent rabbits with noxious colorectal distension for only 2 h over 3 weeks simulated the human child abuse in amplitude, frequency, and duration. Thermal withdrawal thresholds were unchanged suggesting that sensitized spinal mechanisms may not be operable. Unchanged weight, stools, colorectal histology, and no evidence of abdominal pain argue against tissue injury or irritable bowel syndrome...
August 31, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28860846/ambroxol-for-the-treatment-of-fibromyalgia-science-or-fiction
#12
Kai-Uwe Kern, Myriam Schwickert
Fibromyalgia appears to present in subgroups with regard to biological pain induction, with primarily inflammatory, neuropathic/neurodegenerative, sympathetic, oxidative, nitrosative, or muscular factors and/or central sensitization. Recent research has also discussed glial activation or interrupted dopaminergic neurotransmission, as well as increased skin mast cells and mitochondrial dysfunction. Therapy is difficult, and the treatment options used so far mostly just have the potential to address only one of these aspects...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28852456/a-rare-diaphragmatic-hernia-with-a-delayed-presentation-of-intestinal-symptoms-following-spleno-distal-pancreatectomy-a-case-report
#13
Giancarlo Pansini, Giovanni Pascale, Ilaria Pigato, Enzo Malvicini, Dario Andreotti, Annalisa Caruso, Rocco Stano, Savino Occhionorelli
Acquired diaphragmatic hernia, non-related to trauma, is a very rare condition. It can constitute a therapeutic problem and the surgical solution is not always immediately clear. We report the case of a 73-year-old woman with a history of spleno-distal pancreatectomy for a neuroendocrine tumour performed in 2009, who came back to Emergency Room 2 years later, complaining of abdominal pain. Chest radiography and computed tomography were performed; they showed a diaphragmatic hernia with visceral migration into the thorax...
July 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28844004/altered-intrinsic-and-synaptic-properties-of-lumbosacral-dorsal-horn-neurons-in-a-mouse-model-of-colitis
#14
Kristen E Farrell, Simon Keely, Marjorie M Walker, Alan M Brichta, Brett A Graham, Robert J Callister
Visceral pain in inflammatory and functional gastrointestinal conditions is a major clinical problem. The exact mechanisms underlying the development of pain, during and after visceral inflammation are unknown. However, clinical and pre-clinical evidence suggests plasticity within the spinal cord dorsal horn is a contributing factor. Here we use an in vivo preparation and patch-clamp electrophysiology to test whether the synaptic and intrinsic properties of superficial dorsal horn (SDH) neurons are altered 5days after the induction of mild colitis in adult male mice (i...
August 23, 2017: Neuroscience
https://www.readbyqxmd.com/read/28843368/echocardiographic-epicardial-adipose-tissue-thickness-is-associated-with-symptomatic-coronary-vasospasm-during-provocative-testing
#15
Susumu Nishio, Kenya Kusunose, Hirotsugu Yamada, Yukina Hirata, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro, Masataka Sata
BACKGROUND: Epicardial adipose tissue (EAT) is the ectopic visceral fat surrounding the heart, which plays an important role in atherosclerosis of the coronary arteries via endothelial damage. Several studies have also suggested that vasospasm with angina (VSA) causes endothelial dysfunction in the coronary arteries. The aim of this study was to evaluate the thickness of EAT in the anterior interventricular groove (EAT-AIG) using echocardiography in patients who had no obstructive coronary artery disease and were suspected of having VSA...
August 23, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28841834/cutaneous-leishmaniasis-in-a-severely-immunocompromised-hiv-patient-in-kumbo-northwest-region-of-cameroon-case-report
#16
Larry N Tangie, A Desmond, Leopold N Aminde, Annabel M Ako, P M Halle
BACKGROUND: Leishmaniasis is a rising opportunistic infection in individuals with human immunodeficiency virus (HIV). Cases of leishmania and HIV co-infection have been documented in several countries in the world with most reporting on the association between visceral leishmaniasis (VL) and HIV. We herein report the case of cutaneous leishmaniasis (CL) occurring in an HIV seropositive patient. CASE PRESENTATION: A 28 year old Cameroonian female diagnosed with HIV for 6 months earlier, presented to our facility with a 3 months history of non-painful rash...
August 25, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28827631/improved-efficacy-and-in-vivo-cellular-properties-of-human-embryonic-stem-cell-derivative-in-a-preclinical-model-of-bladder-pain-syndrome
#17
Aram Kim, Hwan Yeul Yu, Jisun Lim, Chae-Min Ryu, Yong Hwan Kim, Jinbeom Heo, Ju-Young Han, Seungun Lee, Yoon Sung Bae, Jae Young Kim, Dong-Jun Bae, Sang-Yeob Kim, Byeong-Joo Noh, Ki-Sung Hong, Ji-Yeon Han, Sang Wook Lee, Miho Song, Hyung-Min Chung, Jun Ki Kim, Dong-Myung Shin, Myung-Soo Choo
Interstitial cystitis/bladder pain syndrome (IC/BPS) is an intractable disease characterized by severe pelvic pain and urinary frequency. Mesenchymal stem cell (MSC) therapy is a promising approach to treat incurable IC/BPS. Here, we show greater therapeutic efficacy of human embryonic stem cell (hESC)-derived multipotent stem cells (M-MSCs) than adult bone-marrow (BM)-derived counterparts for treating IC/BPS and also monitor long-term safety and in vivo properties of transplanted M-MSCs in living animals. Controlled hESC differentiation and isolation procedures resulted in pure M-MSCs displaying typical MSC behavior...
August 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28826626/can-we-treat-visceral-hypersensitivity-in-functional-abdominal-pain
#18
Miranda A L van Tilburg
No abstract text is available yet for this article.
October 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28820703/assessment-of-u-s-pediatrician-knowledge-of-toxocariasis
#19
Dana M Woodhall, Amanda P Garcia, Craig A Shapiro, Shequenta L Wray, Andi L Shane, Chitra S Mani, Kelly K Stimpert, LeAnne M Fox, Susan P Montgomery
Toxocariasis, one of a group of parasitic diseases known as neglected parasitic infections, is a disease caused by the larvae of two species of Toxocara roundworms, Toxocara canis, from dogs, and less commonly Toxocara cati, from cats. Although most infected individuals are asymptomatic, clinical manifestations may include fever, fatigue, coughing, wheezing, or abdominal pain (visceral toxocariasis) or vision loss, retina damage, or eye inflammation (ocular toxocariasis). To assess U.S. pediatrician knowledge of toxocariasis, we conducted an electronic survey of American Academy of Pediatrics members...
July 31, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28815097/pancreaticoduodenal-artery-aneurysm-associated-with-celiac-trunk-stenosis-case-illustration-and-literature-review
#20
Jad A Degheili, Alissar El Chediak, Mohamad Yasser R Dergham, Aghiad Al-Kutoubi, Ali H Hallal
Pancreaticoduodenal artery aneurysms (PDA) are rare visceral aneurysms. Celiac trunk stenosis represents a common attributable aetiology for those aneurysms. Therefore, an alternative treatment approach, which differs from those isolated aneurysms, is recommended. We hereby present a 77-year-old male patient who was admitted with sudden onset of severe abdominal pain and significant drop in haemoglobin, occurring within a 24-hour interval. Contrast-enhanced computed tomography revealed a ruptured visceral aneurysm arising from the anterior branch of the inferior pancreaticoduodenal artery...
2017: Case Reports in Radiology
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