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https://www.readbyqxmd.com/read/28822004/in-vitro-validation-of-the-hippo-pathway-as-a-pharmacological-target-for-canine-mammary-gland-tumors
#1
Samantha Guillemette, Charlène Rico, Philippe Godin, Derek Boerboom, Marilène Paquet
Canine mammary tumors (CMTs) are the most common neoplasms in intact female dogs. Some clinical and molecular similarities between certain CMT subtypes and breast cancer make them a potential model for the study of the human disease. As misregulated Hippo signaling is thought to play an important role in breast cancer development and also occurs in CMTs, we sought to determine if Hippo represents a valid pharmacological target for the treatment of CMTs. Six CMT cell lines were assessed for their expression of the Hippo pathway effectors YAP and TAZ and for their sensitivity to verteporfin, an inhibitor of YAP-mediated transcriptional coactivation...
August 18, 2017: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/28813665/lineage-restricted-mammary-stem-cells-sustain-the-development-homeostasis-and-regeneration-of-the-estrogen-receptor-positive-lineage
#2
Alexandra Van Keymeulen, Marco Fioramonti, Alessia Centonze, Gaëlle Bouvencourt, Younes Achouri, Cédric Blanpain
The mammary gland (MG) is composed of different cell lineages, including the basal and the luminal cells (LCs) that are maintained by distinct stem cell (SC) populations. LCs can be subdivided into estrogen receptor (ER)(+) and ER(-) cells. LCs act as the cancer cell of origin in different types of mammary tumors. It remains unclear whether the heterogeneity found in luminal-derived mammary tumors arises from a pre-existing heterogeneity within LCs. To investigate LC heterogeneity, we used lineage tracing to assess whether the ER(+) lineage is maintained by multipotent SCs or by lineage-restricted SCs...
August 15, 2017: Cell Reports
https://www.readbyqxmd.com/read/28812531/prolactinoma-in-a-dog
#3
Cristina Cosio, Elena Sartori, Marcello Garatti, Lorenzo Luccardini, G C M Grinwis, Hans S Kooistra, Federico Fracassi
A 12-year-old male Yorkshire Terrier was presented because of decreased appetite. Physical examination revealed mammary gland swelling and galactorrhea. Contrast-enhanced computed tomographic scanning of the skull indicated an enlarged pituitary gland, compatible with a pituitary tumor. The serum prolactin concentration was markedly elevated. One week after the start of treatment with the dopamine agonist cabergoline, the serum prolactin concentration normalized and the galactorrhea resolved. Cabergoline was administered for approximately 4 months and then discontinued...
January 1, 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/28801701/the-overexpression-of-hsp90b1-is-associated-with-tumorigenesis-of-canine-mammary-glands
#4
B V Sunil Kumar, Rabia Bhardwaj, Kanika Mahajan, Neeraj Kashyap, Ashwani Kumar, Ramneek Verma
Heat shock proteins (Hsp) are molecular chaperones that are responsible for protein folding and maintenance of cellular homeostasis. Hsp90, an important member of HSP family, has an important role in breast cancer. Glucose-regulated protein 94 (Grp94) is the endoplasmic reticulum paralog of Hsp90 encoded by Hsp90B1 gene. To test if this protein is overexpressed in dogs with mammary tumor, we estimated and compared its serum levels in healthy dogs and that of dogs with mammary tumors. Hsp90B1 mRNA expression was measured in tumorous and healthy mammary tissues (from age- and breed-matched dogs) by real-time PCR...
August 12, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28799678/processing-and-characterization-of-canine-mixed-mammary-tumor-using-transmission-electron-microscopy
#5
Beltrán Audrey, Debut Alexis, Vaca Andrea, Ortiz Julio, Proaño-Pérez Freddy
Canine mammary gland tumors represent the second most frequent type of neoplasm in dogs, being an important problem within veterinary medical field. Canine mixed mammary tumors are the most common; the use of a transmission electron microscope (TEM) can contribute as a tool in its diagnosis by determining the characteristics of cellular components from numerous neoplasms. The aim of this study was to characterize cytologically canine mammary mixed tumor by the use of the TEM. A biopsy collected from an 11 years old bitch Shih-Tzu and analyzed by histopathology was used for ultrastructural analysis...
August 11, 2017: Microscopy Research and Technique
https://www.readbyqxmd.com/read/28798533/a-spontaneous-myoepithelial-carcinoma-in-the-mammary-gland-of-an-aged-female-icr-cd-1-mouse
#6
Tsuyoshi Ito, Toshinori Yoshida, Katsumi Soma, Yoshitaka Katoh, Yuko Shimada, Aya Ohnuma-Koyama, Naofumi Takahashi, Yoshimasa Okazaki, Atsushi Shiga, Maki Kuwahara, Takanori Harada
We report a female Crlj:CD1(ICR) mouse with a spontaneous mammary gland tumor composed of biphasic tumor cells, i.e., epithelioid and spindle-shaped myoepithelial cells. Macroscopically, a subcutaneous mass, approximately 3 cm in diameter was found in the lumbodorsal region. Histopathologically, the epithelioid cells proliferated in an alveolar or nest-like growth pattern, occasionally forming glandular-like structures. On the other hand, the spindle-shaped cells proliferated in a sarcomatous pattern. Normal mammary gland was observed in the vicinity of the tumor...
July 2017: Journal of Toxicologic Pathology
https://www.readbyqxmd.com/read/28798322/luciferase-expression-allows-bioluminescence-imaging-but-imposes-limitations-on-the-orthotopic-mouse-4t1-model-of-breast-cancer
#7
V P Baklaushev, A Kilpeläinen, S Petkov, M A Abakumov, N F Grinenko, G M Yusubalieva, A A Latanova, I L Gubskiy, F G Zabozlaev, E S Starodubova, T O Abakumova, M G Isaguliants, V P Chekhonin
Implantation of reporter-labeled tumor cells in an immunocompetent host involves a risk of their immune elimination. We have studied this effect in a mouse model of breast cancer after the orthotopic implantation of mammary gland adenocarcinoma 4T1 cells genetically labelled with luciferase (Luc). Mice were implanted with 4T1 cells and two derivative Luc-expressing clones 4T1luc2 and 4T1luc2D6 exhibiting equal in vitro growth rates. In vivo, the daughter 4T1luc2 clone exhibited nearly the same, and 4T1luc2D6, a lower growth rate than the parental cells...
August 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28794644/the-rank-rankl-opg-system-in-tumorigenesis-and-metastasis-of-cancer-stem-cell-potential-targets-for-anticancer-therapy
#8
REVIEW
Mekonnen Sisay, Getnet Mengistu, Dumessa Edessa
The molecular triad involving receptor activator of nuclear factor kβ (RANK)/RANK ligand (RANKL)/osteoprotegerin cytokine system has been well implicated in several physiological and pathological processes including bone metabolism, mammary gland development, regulation of the immune function, tumorigenesis and metastasis of cancer stem cell, thermoregulation, and vascular calcification. However, this review aimed to summarize several original and up-to-date articles focusing on the role of this signaling system in cancer cell development and metastasis as well as potential therapeutic agents targeting any of the three tumor necrotic factor super family proteins and/or their downstream signaling pathways...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28791998/-fibroepithelial-tumors-of-the-anogenital-mammary-like-glands
#9
A M Konstantinova, K V Shelekhova
Mammary-like glands are a normal anatomical component of the anogenital region. The tumors occurring in them morphologically mimic the similar diseases of the breast. The paper presents a case of vulvar fibroadenoma with leaf-like outgrowths and apocrine metaplasia in a 38-year-old female patient. It describes the clinical and morphological characteristics of fibroadenomas and benign phyllodes tumors in the anogenital region.
2017: Arkhiv Patologii
https://www.readbyqxmd.com/read/28791287/bidirectional-mast-cell-eosinophil-interactions-in-inflammatory-disorders-and-cancer
#10
REVIEW
Maria Rosaria Galdiero, Gilda Varricchi, Mansour Seaf, Giancarlo Marone, Francesca Levi-Schaffer, Gianni Marone
Human mast cells (MCs) and eosinophils were first described and named by Paul Ehrlich. These cells have distinct myeloid progenitors and differ morphologically, ultrastructurally, immunologically, biochemically, and pharmacologically. However, MCs and eosinophils play a pivotal role in several allergic disorders. In addition, these cells are involved in autoimmune disorders, cardiovascular diseases, and cancer. MCs are distributed throughout all normal human tissues, whereas eosinophils are present only in gastrointestinal tract, secondary lymphoid tissues, and adipose tissue, thymus, mammary gland, and uterus...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28781197/clinicopathologic-and-molecular-characterization-of-mammary-analogue-secretory-carcinoma-of-salivary-gland-origin
#11
F Baghai, F Yazdani, A Etebarian, A Garajei, A Skalova
BACKGROUND: Mammary analogue secretory carcinoma (MASC) is a newly recognized salivary gland tumor that harbors a characteristic balanced chromosomal translocation t (12; 15) (p13; q25) resulting in an ETV6-NTRK3 fusion gene. METHODS: Retrospective study of 111 salivary gland carcinomas revealed 37 cases with secretory features and growth patterns resembling secretory carcinoma of breast. These 37 cases were originally diagnosed as acinic cell carcinoma, adenocarcinoma not otherwise specified and cystadenocarcinoma...
July 23, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28781034/evidence-based-advances-in-rodent-medicine
#12
REVIEW
Vladimir Jekl, Karel Hauptman, Zdenek Knotek
The number of exotic companion pet rodents seen in veterinary practices is growing very rapidly. According to the American Veterinary Medical Association's surveys, more than 2,093,000 pet rodents were kept in US households in 2007 and in 2012 it was more than 2,349,000 animals. This article summarizes the most important evidence-based knowledge in exotic pet rodents (diagnostics of the hyperadrenocorticism in guinea pigs, pituitary tumors in rats, urolithiasis in guinea pigs, use of itopride as prokinetics, use of deslorelin acetate in rodents, cause of dental disease, and prevention of mammary gland tumors in rats)...
September 2017: Veterinary Clinics of North America. Exotic Animal Practice
https://www.readbyqxmd.com/read/28759043/genome-wide-screen-for-differentially-methylated-long-noncoding-rnas-identifies-esrp2-and-lncrna-esrp2-as-regulated-by-enhancer-dna-methylation-with-prognostic-relevance-for-human-breast-cancer
#13
K Heilmann, R Toth, C Bossmann, K Klimo, C Plass, C Gerhauser
The majority of long noncoding RNAs (lncRNAs) is still poorly characterized with respect to function, interactions with protein-coding genes, and mechanisms that regulate their expression. As for protein-coding RNAs, epigenetic deregulation of lncRNA expression by alterations in DNA methylation might contribute to carcinogenesis. To provide genome-wide information on lncRNAs aberrantly methylated in breast cancer we profiled tumors of the C3(1) SV40TAg mouse model by MCIp-seq (Methylated CpG Immunoprecipitation followed by sequencing)...
July 31, 2017: Oncogene
https://www.readbyqxmd.com/read/28754862/human-her2-overexpressing-mouse-breast-cancer-cell-lines-derived-from-mmtv-f-huher2-mice-characterization-and-use-in-a-model-of-metastatic-breast-cancer
#14
Sunju Park, Jessie R Nedrow, Anders Josefsson, George Sgouros
Preclinical evaluation of therapeutic agents against metastatic breast cancer require cell lines and animal models that recapitulate clinical metastatic breast cancer as much as possible. We have previously used cell lines derived from the neu-N transgenic model to investigate anti-neu targeting of metastatic breast cancer using an alpha-emitter labeled antibody reactive with the rat variant of HER2/neu expressed by the neu-N model. To investigate alpha-particle emitter targeting of metastatic breast cancer using clinically relevant, commercially available anti-HER2/neu antibodies, we have developed cell lines derived from primary tumors and lung metastases from HuHER2 transgenic mice...
July 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28754015/human-chorionic-gonadotropin-and-breast-cancer
#15
REVIEW
Susanne Schüler-Toprak, Oliver Treeck, Olaf Ortmann
Breast cancer is well known as a malignancy being strongly influenced by female steroids. Pregnancy is a protective factor against breast cancer. Human chorionic gonadotropin (HCG) is a candidate hormone which could mediate this antitumoral effect of pregnancy. For this review article, all original research articles on the role of HCG in breast cancer were considered, which are listed in PubMed database and were written in English. The role of HCG in breast cancer seems to be a paradox. Placental heterodimeric HCG acts as a protective agent by imprinting a permanent genomic signature of the mammary gland determining a refractory condition to malignant transformation which is characterized by cellular differentiation, apoptosis and growth inhibition...
July 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28753556/inflammation-and-stem-markers-association-to-pim1-pim2-kinase-induced-tumors-in-breast-and-uterus
#16
Manuel-Pedro Jiménez-García, Antonio Lucena-Cacace, María-José Robles-Frías, Irene Ferrer, Maja Narlik-Grassow, Carmen Blanco-Aparicio, Amancio Carnero
The PIM family of Ser/Thr kinase proteins has been implicated in tumorigenesis at different levels. PIM proteins are overexpressed in several tumor types and have been associated with chemoresistance. However, their role in hormone-dependent female tissues has not been explored, especially in the uterus, breast and ovary. We generated conditional transgenic mice with confined expression of human PIM1 or PIM2 genes in these tissues. We characterized the tumoral response to these genetic alterations corroborating their role as oncogenes since they induce hyperproliferation in all tissues and tumors in mammary gland and uterus...
July 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28746837/vitamin-d-and-breast-cancer-past-and-present
#17
JoEllen Welsh
The presence of the vitamin D receptor in mammary gland and breast cancer has been recognized since the early 1980s, and multiple pre-clinical studies have demonstrated that its ligand 1,25D modulates normal mammary gland development and sensitivity to carcinogenesis. Although studies have characterized many 1,25D responsive targets in normal mammary cells and in breast cancers, validation of relevant targets that regulate cell cycle, apoptosis, autophagy and differentiation, particularly in vivo, has been challenging...
July 23, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28739497/salivary-gland-epithelial-neoplasms-in-pediatric-population-a-single-institute-experience-with-a-focus-on-the-histologic-spectrum-and-clinical-outcome
#18
Bin Xu, Amandeep Aneja, Ronald Ghossein, Nora Katabi
Salivary gland epithelial neoplasms are rare in children and adolescents with only a handful of large series have been published. A retrospective study was conducted for 57 cases in patients 20years or younger. The tumors were located in the parotid (n=36), submandibular gland (n=7), and minor salivary glands (n=14). 19 (33%) tumors were pleomorphic adenoma, while the remaining (67%) were malignant. The histologic types of carcinomas were mucoepidermoid carcinoma (MEC, n=19, 33%), acinic cell carcinoma (n=7, 12%), adenoid cystic carcinoma (n=6, 11%), secretory carcinoma (mammary analogue) (SC, n=4, 7%), and myoepithelial carcinoma (n=2, 4%)...
July 21, 2017: Human Pathology
https://www.readbyqxmd.com/read/28739144/contrast-enhancement-in-breast-cancer-and-background-mammary-gland-tissue-during-the-super-early-phase-of-dynamic-breast-magnetic-resonance-imaging
#19
Tetsuya Tomida, Atsushi Urikura, Takayoshi Uematsu, Kensei Shirata, Yoshihiro Nakaya
RATIONALE AND OBJECTIVES: We aimed to compare the contrast enhancement between tumor and mammary-gland tissue to distinguish lesions in the super-early phase, during which minimal contrast media uptake is observed in mammary-gland tissue. MATERIALS AND METHODS: Dynamic magnetic resonance imaging, including the super-early phase with bolus tracking (BT) method (to determine the optimal imaging start time), was performed by using identical parameters to obtain transverse fat-suppressed T1-weighted images of both breasts...
July 21, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28738326/difficulty-in-the-cytodiagnosis-of-mammary-analogue-secretory-carcinoma-survey-of-109-cytologists-with-a-case-originating-from-a-minor-salivary-gland
#20
Keita Kai, Akimichi Minesaki, Kumiko Suzuki, Mikio Monji, Mitsuo Nakamura, Hisayuki Tsugitomi, Yuichiro Kuratomi, Shinichi Aishima
BACKGROUND: Mammary analogue secretory carcinoma (MASC) of the salivary gland shows morphologic similarities and shares an immunophenotype and characteristic ETV6-NTRK3 translocation with secretory carcinoma of the breast. We present a buccal case of MASC along with a survey-based debate about its cytologic diagnosis by fine-needle aspiration (FNA). CASE: FNA of the buccal nodule of a 58-year-old Japanese man was initially performed by 3 cytologists who gave different assessments of the Papanicolaou classification (i...
July 25, 2017: Acta Cytologica
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