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Fucoidan

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https://www.readbyqxmd.com/read/28106881/phylogenomics-of-rhodobacteraceae-reveals-evolutionary-adaptation-to-marine-and-non-marine-habitats
#1
Meinhard Simon, Carmen Scheuner, Jan P Meier-Kolthoff, Thorsten Brinkhoff, Irene Wagner-Döbler, Marcus Ulbrich, Hans-Peter Klenk, Dietmar Schomburg, Jörn Petersen, Markus Göker
Marine Rhodobacteraceae (Alphaproteobacteria) are key players of biogeochemical cycling, comprise up to 30% of bacterial communities in pelagic environments and are often mutualists of eukaryotes. As 'Roseobacter clade', these 'roseobacters' are assumed to be monophyletic, but non-marine Rhodobacteraceae have not yet been included in phylogenomic analyses. Therefore, we analysed 106 genome sequences, particularly emphasizing gene sampling and its effect on phylogenetic stability, and investigated relationships between marine versus non-marine habitat, evolutionary origin and genomic adaptations...
January 20, 2017: ISME Journal
https://www.readbyqxmd.com/read/28104371/in-vitro-and-in-vivo-evaluation-of-anti-arthritic-antioxidant-efficacy-of-fucoidan-from-undaria-pinnatifida-harvey-suringar
#2
Abdul-Rehman Phull, Muhammad Majid, Ihsan-Ul Haq, Muhammad Rashid Khan, Song Ja Kim
Seaweed and their constituents have been traditionally employed for the management of various human pathologic conditions such as edema, urinary disorders and inflammatory anomalies. The current study was performed to investigate the antioxidant and anti-arthritic effects of fucoidan from Undaria pinnatifida. A noteworthy in vitro antioxidant potential at 500μg/ml in 2, 2-diphenyl-1-picrylhydrazyl scavenging assay (80% inhibition), nitrogen oxide inhibition assay (71.83%), hydroxyl scavenging assay (71.92%), iron chelating assay (73...
January 16, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28098144/oligo-fucoidan-prevents-renal-tubulointerstitial-fibrosis-by-inhibiting-the-cd44-signal-pathway
#3
Cheng-Hsien Chen, Yuh-Mou Sue, Chung-Yi Cheng, Yen-Cheng Chen, Chung-Te Liu, Yung-Ho Hsu, Pai-An Hwang, Nai-Jen Huang, Tso-Hsiao Chen
Tubulointerstitial fibrosis is recognized as a key determinant of progressive chronic kidney disease (CKD). Fucoidan, a sulphated polysaccharide extracted from brown seaweed, exerts beneficial effects in some nephropathy models. The present study evaluated the inhibitory effect of oligo-fucoidan (800 Da) on renal tubulointerstitial fibrosis. We established a mouse CKD model by right nephrectomy with transient ischemic injury to the left kidney. Six weeks after the surgery, we fed the CKD mice oligo-fucoidan at 10, 20, and 100 mg/kg/d for 6 weeks and found that the oligo-fucoidan doses less than 100 mg/kg/d improved renal function and reduced renal tubulointerstitial fibrosis in CKD mice...
January 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28094330/inhibition-of-influenza-a-virus-infection-by-fucoidan-targeting-viral-neuraminidase-and-cellular-egfr-pathway
#4
Wei Wang, Jiandong Wu, Xiaoshuang Zhang, Cui Hao, Xiaoliang Zhao, Guangling Jiao, Xindi Shan, Wenjing Tai, Guangli Yu
Development of novel anti-influenza A virus (IAV) drugs with high efficiency and low toxicity is critical for preparedness against influenza outbreaks. Herein, we investigated the anti-IAV activities and mechanisms of fucoidan in vitro and in vivo. The results showed that a fucoidan KW derived from brown algae Kjellmaniella crassifolia effectively blocked IAV infection in vitro with low toxicity. KW possessed broad anti-IAV spectrum and low tendency of induction of viral resistance, superior to the anti-IAV drug amantadine...
January 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28060735/the-natural-compound-fucoidan-from-new-zealand-undaria-pinnatifida-synergizes-with-the-erbb-inhibitor-lapatinib-enhancing-melanoma-growth-inhibition
#5
Varsha Thakur, Jun Lu, Giuseppe Roscilli, Luigi Aurisicchio, Manuela Cappelletti, Emiliano Pavoni, William Lindsey White, Barbara Bedogni
Melanoma remains one of the most aggressive and therapy-resistant cancers. Finding new treatments to improve patient outcomes is an ongoing effort. We previously demonstrated that melanoma relies on the activation of ERBB signaling, specifically of the ERBB3/ERBB2 cascade. Here we show that melanoma tumor growth is inhibited by 60% over controls when treated with lapatinib, a clinically approved inhibitor of ERBB2/EGFR. Importantly, tumor growth is further inhibited to 85% when the natural compound fucoidan from New Zealand U...
January 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28035379/antinociceptive-effects-of-fucoidan-in-rat-models-of-vincristine-induced-neuropathic-pain
#6
Chuanyin Hu, Yun-Tao Zhao, Guoping Zhang, Ming-Feng Xu
Chemotherapeutic drugs commonly induce peripheral neuropathic pain, which limit their clinic use. In the present study, the effect of fucoidan on the development of vincristine‑induced neuropathic pain was evaluated and the underlying mechanism was examined. A neuropathy model was established in Sprague‑Dawley rats by intraperitoneal injection of vincristine sulfate 50 µg/kg once a day for 10 consecutive days. Fucoidan (50, 100 or 200 mg/kg.) and pregabalin (10 mg/kg) were injected for 14 consecutive days...
February 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28031251/expression-and-biochemical-characterization-and-substrate-specificity-of-the-fucoidanase-from-formosa-algae
#7
Artem S Silchenko, Nadezhda E Ustyuzhanina, Mikhail I Kusaykin, Vadim B Krylov, Alexander S Shashkov, Andrey S Dmitrenok, Roza V Usoltseva, Anastasiya O Zueva, Nikolay E Nifantiev, Tatyana N Zvyagintseva
A gene that encodes fucoidanase ffa2 in the marine bacterium Formosa algae strain KMM 3553(T) was cloned, and the protein (FFA2) was produced in Escherichia coli Recombinant fucoidanase FFA2 was purified, and the biochemical properties of this enzyme were studied. The amino acid sequence of FFA2 showed 57% identity with known fucoidanase FcnA from Mariniflexile fucanivorans. The mass of the gene product FFA2 is 101.2 kDa (918 amino acid residues). Sequence analysis has revealed that fucoidanase FFA2 belongs to the GH107 (CAZy) family...
December 28, 2016: Glycobiology
https://www.readbyqxmd.com/read/28008779/the-effect-of-undaria-pinnatifida-fucoidan-on-the-pharmacokinetics-of-letrozole-and-tamoxifen-in-patients-with-breast-cancer
#8
Shreya Tocaciu, Lesley J Oliver, Ray M Lowenthal, Gregory M Peterson, Rahul Patel, Madhur Shastri, Georgia McGuinness, Inger Olesen, J Helen Fitton
BACKGROUND: Although the use of complementary and alternative medicines is widespread in cancer patients, clinical evidence of their benefits is sparse. Furthermore, while they are often assumed to be safe with regard to concurrent use of anticancer therapies, few studies have been carried out to investigate possible interactions. Fucoidans are a group of sulfated carbohydrates, derived from marine brown algae, which have long been used as dietary supplements due to their reported medicinal properties, including anticancer activity...
December 1, 2016: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/28004293/fucoidan-reduced-the-invasion-of-oral-squamous-cell-carcinoma-cells-and-modified-their-effects-to-macrophages
#9
Junda Lin, Ketao Wang, Huayang Wang, Qianqian Shao, Yijun Luan, Yan Xu, Xiaobin Song, Wanye Tan, Shaohua Liu, Fengcai Wei, Xun Qu
Fucoidan is a complex of polysaccharides showing antitumor and immunomodulation properties. Our previous studies found its regulation to myeloid immune cells, including macrophages. Aberrant infiltration and functions of macrophages are commonly found in oral squamous cell carcinoma (OSCC). In this study, we analyzed the effects of fucoidan on invasion of OSCC cells, and their regulation to macrophages, trying to evaluate its role as a potential therapy for OSCC. CAL27 and THP-1-derived macrophages were used as models for OSCC cells and tumor-infiltrated macrophages in the in vitro study, respectively...
January 2017: Medical Oncology
https://www.readbyqxmd.com/read/28000877/low%C3%A2-molecular-weight-fucoidan-inhibits-the-differentiation-of-osteoclasts-and-reduces-osteoporosis-in-ovariectomized-rats
#10
Xin Jin, Liguo Zhu, Xiulan Li, Jian Jia, Yang Zhang, Xiaolei Sun, Jianxiong Ma, Zhaojie Liu, Xinlong Ma
Fucoidan is a type of sulfated polysaccharide isolated from seaweed. The present study used ovariectomized Sprague‑Dawley rats, which were treated with fucoidan. The effects of fucoidan on bone metabolism, density and microarchitecture were assessed using micro‑computed tomography (CT), histomorphometric analysis, biochemical markers of bone metabolism (Serum procollagen type I N propeptide and C‑terminal telopeptide‑1) and tests of mechanical competence of the femur. In addition, the effects of low‑molecular weight fucoidan (LMWF) on in vitro cultured osteoclasts were examined, in order to determine the mechanisms underlying LMWF‑induced osteoclastic inhibition...
February 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27996198/the-key-role-of-sulfation-and-branching-on-fucoidan-antitumor-activity
#11
Catarina Oliveira, Andreia S Ferreira, Ramon Novoa-Carballal, Cláudia Nunes, Iva Pashkuleva, Nuno M Neves, Manuel A Coimbra, Rui L Reis, Albino Martins, Tiago H Silva
There is an urgent need for antitumor bioactive agents with minimal or no side effects over normal adjacent cells. Fucoidan is a marine-origin polymer with known antitumor activity. However, there are still some concerns about its application due to the inconsistent experimental results, specifically its toxicity over normal cells and the mechanism behind its action. Herein, three fucoidan extracts (FEs) have been tested over normal and breast cancer cell lines. From cytotoxicity results, only one of the extracts shows selective antitumor behavior (at 0...
December 20, 2016: Macromolecular Bioscience
https://www.readbyqxmd.com/read/27994679/brown-seaweed-fucoidan-inhibits-cancer-progression-by-dual-regulation-of-mir-29c-adam12-and-mir-17-5p-pten-axes-in-human-breast-cancer-cells
#12
Szu-Yuan Wu, Alexander T H Wu, Kevin Sheng-Po Yuan, Shing Hwa Liu
In this study, we observed that brown seaweed fucoidan inhibited human breast cancer progression by upregulating microRNA (miR)-29c and downregulating miR-17-5p, thereby suppressing their target genes, a disintegrin and metalloproteinase 12 (ADAM12) and phosphatase and tensin homolog (PTEN), respectively. Moreover, fucoidan reduced the luciferase activity of 3'-untranslated region reporter; treatment of cells with the miR-29c mimic or miR-17-5p inhibitor also produced similar results. These effects of fucoidan inhibited the epithelial-mesenchymal transition in breast cancer cells, as evidenced by an increase in E-cadherin and a drop in N-cadherin, and inhibited breast cancer cell survival, as evidenced by the activation of the phosphoinositide 3-kinase/Akt pathway...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27987862/structural-features-and-anticancer-activity-in-vitro-of-fucoidan-derivatives-from-brown-alga-saccharina-cichorioides
#13
Stanislav D Anastyuk, Natalia M Shevchenko, Roza V Usoltseva Menshova, Artyom S Silchenko, Pavel A Zadorozhny, Pavel S Dmitrenok, Svetlana P Ermakova
A fucoidan ScF from brown alga Saccharina cichorioides was extracted, purified and partially depolymerized by autohydrolysis at 37°C for 24, 48 and 72h. Supernatant (SN) and pellet (PL) fractions were obtained by ethanol precipitation of each sample. Unlike spectral data of ScF, NMR of PL derivatives clearly suggested the structure: 1,3-linked α-l-Fucp-4-OSO3(-) repeating unit. Molecular weights (MWs) of PL fractions were 30, 26 and 18kDa for 24, 48 and 72h of autohydrolyis, respectively. MALDI-TOFMS, size-exclusion HPLC and carbohydrate polyacrylamide-gel electrophoresis (C-PAGE) indicated a similarity of SN mixtures...
February 10, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27987467/fucoidan-inhibits-lps-induced-inflammation-in-vitro-and-during-the-acute-response-in-vivo
#14
Jisang Park, Jeong-Dan Cha, Kyung-Min Choi, Kyung-Yeol Lee, Kang Min Han, Yong-Suk Jang
Studies have been focused on natural products with antibacterial and anti-inflammatory activities, such as fucoidan. Many in vivo studies have evaluated the effect of fucoidan on tumor growth, diabetes, obesity, ischemia reperfusion, and oxidative stress. However, the effects of fucoidan on bacteria-induced gingival inflammation and periodontitis have not been reported. We previously characterized the anti-inflammatory effect of fucoidan in vitro. Here, we confirmed the anti-inflammatory activity of fucoidan in a macrophage cell line in terms of its inhibition of the expression of inflammatory mediators and pro-inflammatory cytokines...
February 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/27943662/development-of-polymer-microcapsules-functionalized-with-fucoidan-to-target-p-selectin-overexpressed-in-cardiovascular-diseases
#15
Bo Li, Maya Juenet, Rachida Aid-Launais, Murielle Maire, Véronique Ollivier, Didier Letourneur, Cédric Chauvierre
New tools for molecular imaging and targeted therapy for cardiovascular diseases are still required. Herein, biodegradable microcapsules (MCs) made of polycyanoacrylate and polysaccharide and functionalized with fucoidan (Fuco-MCs) are designed as new carriers to target arterial thrombi overexpressing P-selectin. Physicochemical characterizations demonstrated that microcapsules have a core-shell structure and that fucoidan is present onto the surface of Fuco-MCs. Furthermore, their sizes range from 2 to 6 µm and they are stable on storage over 30 d at 4 °C...
December 12, 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27941599/marine-algae-as-a-potential-source-for-anti-obesity-agents
#16
REVIEW
Chu Wan-Loy, Phang Siew-Moi
Obesity is a major epidemic that poses a worldwide threat to human health, as it is also associated with metabolic syndrome, type 2 diabetes and cardiovascular disease. Therapeutic intervention through weight loss drugs, accompanied by diet and exercise, is one of the options for the treatment and management of obesity. However, the only approved anti-obesity drug currently available in the market is orlistat, a synthetic inhibitor of pancreatic lipase. Other anti-obesity drugs are still being evaluated at different stages of clinical trials, while some have been withdrawn due to their severe adverse effects...
December 7, 2016: Marine Drugs
https://www.readbyqxmd.com/read/27918447/enhanced-antimicrobial-and-anticancer-activity-of-silver-and-gold-nanoparticles-synthesised-using-sargassum-incisifolium-aqueous-extracts
#17
Mokone Mmola, Marilize Le Roes-Hill, Kim Durrell, John J Bolton, Nicole Sibuyi, Mervin E Meyer, Denzil R Beukes, Edith Antunes
A detailed, methodical approach was used to synthesise silver and gold nanoparticles using two differently prepared aqueous extracts of the brown algae Sargassum incisifolium. The efficiency of the extracts in producing nanoparticles were compared to commercially available brown algal fucoidans, a major constituent of brown algal aqueous extracts. The nanoparticles were characterised using TEM, XRD and UV/Vis spectroscopy and zeta potential measurements. The rate of nanoparticle formation was assessed using UV/Vis spectroscopy and related to the size, shape and morphology of the nanoparticles as revealed by TEM...
December 2, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27896028/the-scavenger-receptor-repertoire-in-six-cnidarian-species-and-its-putative-role-in-cnidarian-dinoflagellate-symbiosis
#18
Emilie F Neubauer, Angela Z Poole, Virginia M Weis, Simon K Davy
Many cnidarians engage in a mutualism with endosymbiotic photosynthetic dinoflagellates that forms the basis of the coral reef ecosystem. Interpartner interaction and regulation includes involvement of the host innate immune system. Basal metazoans, including cnidarians have diverse and complex innate immune repertoires that are just beginning to be described. Scavenger receptors (SR) are a diverse superfamily of innate immunity genes that recognize a broad array of microbial ligands and participate in phagocytosis of invading microbes...
2016: PeerJ
https://www.readbyqxmd.com/read/27871155/protective-role-of-fucoidan-in-cerebral-ischemia-reperfusion-injury-through-inhibition-of-mapk-signaling-pathway
#19
Nan Che, Yijie Ma, Yinhu Xin
Fucoidan has been reported to exhibit various beneficial activities ranging from to antivirus and anticancer properties. However, little information is available about the effects of fucoidan on cerebral ischemia-reperfusion injury (IRI). Our study aimed to explore the effects of fucoidan on cerebral IRI, as well as the underlying mechanisms. Sprague-Dawley (SD) rats were randomly subjected to four groups: Sham, IRI+saline (IRI+S), IRI+80 mg/kg fucoidan (IRI+F80), and IRI+160 mg/kg fucoidan (IRI+F160). Fucoidan (80 mg/kg or 160 mg/kg) was intraperitoneally injected from 7 days before the rats were induced to cerebral IRI model with middle cerebral artery occlusion (MCAO) method...
November 25, 2016: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/27815206/white-shrimp-litopenaeus-vannamei-that-have-received-fucoidan-exhibit-a-defense-against-vibrio-alginolyticus-and-wssv-despite-their-recovery-of-immune-parameters-to-background-levels
#20
Yu-Yuan Chen, Suwaree Kitikiew, Su-Tuen Yeh, Jiann-Chu Chen
White shrimp Litopenaeus vannamei receiving fucoidan at 2, 6, and 10 μg g(-1) after 0-144 h or 0-120 h were examined for immune parameters (haemograms, phenoloxidase activity, respiratory burst, and superoxide dismutase activity), proliferation of haemocyte in the haematopoietic tissue (HPT), gene expression, and phagocytic activity and clearance efficiency to Vibrio alginolyticus. Immune parameters and mitotic index of HPT increased after 3-24 h, reached their maxima after 48-72 h, and returned to background values after 144 h...
December 2016: Fish & Shellfish Immunology
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