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Fucoidan

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https://www.readbyqxmd.com/read/29341587/fucoidan-prolongs-the-circulation-time-of-dextran-coated-iron-oxide-nanoparticles
#1
Maha R A Abdollah, Thomas J Carter, Clare Jones, Tammy L Kalber, Vineeth Rajkumar, Berend Tolner, Cordula Gruettner, May Zaw-Thin, Julia Baguña Torres, Matthew Ellis, Mathew Robson, R Barbara Pedley, Paul Mulholland, Rafael T M de Rosales, Kerry Ann Chester
The magnetic properties and safety of dextran-coated superparamagnetic iron oxide nanoparticles (SPIONs) have facilitated their clinical use as MRI contrast agents and stimulated research on applications for SPIONs in particle imaging and magnetic hyperthermia. The wider clinical potential of SPIONs, however, has been limited by their rapid removal from circulation via the reticuloendothelial system (RES). We explored the possibility of extending SPION circulatory time using fucoidan, a seaweed-derived food supplement, to inhibit RES uptake...
January 17, 2018: ACS Nano
https://www.readbyqxmd.com/read/29328495/fucoidan-downregulates-insulin-like-growth-factor-i-receptor-levels-in-ht-29-human-colon-cancer-cells
#2
In-Hye Kim, Taek-Jeong Nam
Fucoidan, a sulfated polysaccharide present in brown seaweed, has demonstrated anticancer activity in lung, breast, liver and colon cells. The insulin-like growth factor (IGF) signaling pathway regulates growth in HT-29 cells through the insulin receptor substrate-1 (IRS-1)/phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) and Ras/Raf/extracellular signal-regulated kinase (ERK) pathways. The aim of the present study was to investigate whether fucoidan downregulates the IGF-IR signaling pathway in HT-29 human colon cancer cells...
January 4, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29324642/antibacterial-and-antioxidant-capacities-and-attenuation-of-lipid-accumulation-in-3t3-l1-adipocytes-by-low-molecular-weight-fucoidans-prepared-from-compressional-puffing-pretreated-sargassum-crassifolium
#3
Chun-Yung Huang, Chia-Hung Kuo, Chia-Hsin Lee
In this study, we extracted fucoidan from compressional-puffing-pretreated Sargassum crassifolium by hot water. The crude extract of fucoidan (SC) was degraded by various degradation reagents and four low-molecular-weight (LMW) fucoidans, namely SCO (degradation by hydrogen peroxide), SCA (degradation by ascorbic acid), SCOA (degradation by hydrogen peroxide + ascorbic acid), and SCH (degradation by hydrogen chloride) were obtained. The degradation reagents studied could effectively degrade fucoidan into LMW fucoidans, as revealed by intrinsic viscosity, agarose gel electrophoresis, and molecular weight analyses...
January 11, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29304524/amino-fucoidan-as-a-vector-for-rtpa-induced-fibrinolysis-in-experimental-thrombotic-events
#4
Radouane Ghebouli, Stephane Loyau, Murielle Maire, Pierre Saboural, Jean-Philippe Collet, Martine Jandrot-Perrus, Didier Letourneur, Frédéric Chaubet, Jean-Baptiste Michel
Acute ischaemic stroke, myocardial infarction and pulmonary embolism are the main causes of mortality and morbidity worldwide. Thrombolysis by intravenous injection of recombinant tissue plasminogen activator (rtPA) remains the most common non-interventional treatment to recanalize occluded vessels. However, this procedure is limited by significant drawbacks, including high doses and bleeding complications. Recent studies showed that fucoidan targets the intraluminal thrombus in vivo. We have developed a chimaera covalently linking fucoidan, able to target platelets within the thrombus, to dilysine, able to non-covalently bind rtPA...
January 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29290496/fucoidan-attenuates-angiotensin-ii-induced-abdominal-aortic-aneurysms-through-the-inhibition-of-c-jun-n-terminal-kinase-and-nuclear-factor-%C3%AE%C2%BAb-activation
#5
Shih-Hung Tsai, Jen-Chun Wang, Wen-I Liao, Yu-Juei Hsu, Chih-Yuan Lin, Min-Tser Liao, Po-Hsun Huang, Shing-Jong Lin
BACKGROUND: Rupture of abdominal aortic aneurysm (AAA) is one of the leading causes of sudden death among the elderly. Most incidental AAAs are below the threshold for intervention at the time of detection; however, there is no evidence that commonly used cardiovascular drugs have clinical beneficial effects on AAA progression. Therefore, in addition to current cardiovascular risk-reducing treatments, an adjunctive medical therapy targeting the regulation of extracellular matrix metabolism is still required in the clinical setting...
December 28, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29287459/bioactivity-of-fucoidan-extracted-from-laminaria-japonica-using-a-novel-procedure-with-high-yield
#6
Dong Zhao, Jian Xu, Xia Xu
Due to antitumor and antioxidant activities, there has been increasing interest in fucoidans, sulfated polysaccharides, from brown algae. Currently, the classic hot water extraction and acid extraction are time-consuming, and can cause the partial cleavage of sulfate esters, leading to bioactivity loss. The present study developed a novel process for extracting fucoidans from Laminaria japonica with 0.5% ethylenediaminetetraacetic acid at 70 °C. Crude fucoidans (CFs) obtained with a yield (∼16%) was purified to different fractions of F1, F2 and F3...
April 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29286349/compressional-puffing-pretreatment-enhances-neuroprotective-effects-of-fucoidans-from-the-brown-seaweed-sargassum-hemiphyllum-on-6-hydroxydopamine-induced-apoptosis-in-sh-sy5y-cells
#7
Chun-Yung Huang, Chia-Hung Kuo, Po-Wei Chen
In this study, a compressional-puffing process (CPP) was used to pretreat Sargassum hemiphyllum (SH) and then fucoidan was extracted from SH by hot water. Three fucoidan extracts, namely SH1 (puffing at 0 kg/cm²); SH2 (puffing at 1.7 kg/cm²); and SH3 (puffing at 10.0 kg/cm²) were obtained, and their compositions and biological activities were evaluated. The results indicate that CPP increased the extraction yield, total sugar content, and molar ratios of sulfate/fucose of fucoidan and decreased molecular weight and impurities of fucoidan...
December 29, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29285521/enhanced-differentiation-of-human-preosteoblasts-on-electrospun-blend-fiber-mats-of-polydioxanone-and-anionic-sulfated-polysaccharides
#8
Nowsheen Goonoo, Archana Bhaw-Luximon, Ulrich Jonas, Dhanjay Jhurry, Holger Schönherr
The viability and differentiation of SaOS-2 preosteoblasts on fiber mats of blends comprising of the biodegradable poly(ester-ether) polydioxanone (PDX) and the sulfate-containing anionic polysaccharides kappa-carrageenan (KCG) and fucoidan (FUC) were investigated for a range of different blend compositions. The detailed analysis of the blend nanofiber properties revealed a different degree of miscibility of PDX and the polysaccharide leading to a different enrichment at the surface of the blend nanofibers, which were observed to be stable in phosphate buffer solution (PBS) for up to 5 weeks...
December 11, 2017: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/29274428/structural-characterization-of-a-polysaccharide-from-sargassum-henslowianum-and-its-immunomodulatory-effect-on-gastric-cancer-rat
#9
Mingyang Han, Peichun Sun, Yuanyuan Li, Gang Wu, Jiewei Nie
A complicated sulfated fucoidan, SHPPB2, was purified from Sargassum henslowianum by DEAE-cellulose 52 and Sephacryl S-300 column chromatography. Via chemical and spectral method, SHPPB2 was found to contain mannose, glucuronic acid, galactose, xylose, and fucose, in a ratio of 17.4: 13.5: 10.5: 16.8: 41.8, as well as 21.4% of sulfate. The methylation analysis demonstrated terminal, 3-, 4-, 2, 3-, and 3, 4- linked fucose, 2-, 2, 3-, 2, 4-, and 2, 4, 6- linked mannose, terminal, 4-, 6-, 2, 4-, 3, 4-, and 3, 6- linked galactose, terminal and 4- linked xylose, and 4- linked glucuronic acid...
December 20, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29260173/fucoidan-inhibits-amyloid-%C3%AE-induced-toxicity-in-transgenic-caenorhabditis-elegans-by-reducing-the-accumulation-of-amyloid-%C3%AE-and-decreasing-the-production-of-reactive-oxygen-species
#10
Xuelian Wang, Kaixuan Yi, Yan Zhao
Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder. As the aging population is increasing, AD is becoming one of the leading causes of disability and death among the elderly. However, currently there is no cure for this disease. Fucoidan is a complex sulfated polysaccharide mainly found in brown seaweed. Recent studies have shown that fucoidan is neuroprotective and may have potential to be used for treating and/or preventing neurodegenerative diseases such as AD. In this study, we investigated the effects and possible mechanisms of fucoidan on Abeta induced toxicity in a transgenic Caenorhabditis elegans (C...
December 20, 2017: Food & Function
https://www.readbyqxmd.com/read/29251618/-evaluation-of-adjuvant-effects-of-fucoidane-from-brown-seaweed-fucus-evanescens-and-its-structural-analogues-for-the-strengthening-vaccines-effectiveness
#11
T A Kuznetsova, L A Ivanushko, E V Persiyanova, A L Shutikova, S P Ermakova, M Yu Khotimchenko, N N Besednova
The use of sulfated polysaccharides from brown seaweed Fucus evanescens as adjuvants (native fucoidan in combination with polyphenols, fucoidan without polyphenols, a product of enzymatic hydrolysis of fucoidan) stimulated the formation of specific antibodies to the surface antigen of the hepatitis B virus (HBs-AG). Immunization of mice with vaccine compositions containing HBs-AG and fucoidan samples resulted in increasing the serum level of the pro-inflammatory (TNF-a, IFN-g, IL-2) cytokines. Increased production of these cytokines was detected in the culture of splenocytes additionally stimulated in vitro by fucoidans or phytohemagglutinin...
November 2017: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
https://www.readbyqxmd.com/read/29242876/correction-dietary-fucoidan-modulates-the-gut-microbiota-in-mice-by-increasing-the-abundance-of-lactobacillus-and-ruminococcaceae
#12
Qingsen Shang, Xindi Shan, Chao Cai, Jiejie Hao, Guoyun Li, Guangli Yu
Correction for 'Dietary fucoidan modulates the gut microbiota in mice by increasing the abundance of Lactobacillus and Ruminococcaceae' by Qingsen Shang et al., Food Funct., 2016, 7, 3224-3232.
December 15, 2017: Food & Function
https://www.readbyqxmd.com/read/29226500/anti-inflammatory-effects-of-propranolol-in-the-temporomandibular-joint-of-female-rats-and-its-contribution-to-antinociceptive-action
#13
F B Zanelatto, E V Dias, J M Teixeira, C R Sartori, C A Parada, C H Tambeli
BACKGROUND: β-Blockers reduce temporomandibular joint (TMJ) pain. We asked whether they also reduce TMJ inflammation and, if so, whether this anti-inflammatory effect contributes to its analgesic action. METHODS: We measured many parameters of the inflammatory response after co-administration of the β-blocker propranolol with the inflammatory agent carrageenan in the TMJ of female rats. We also hypothesized that the activation of β-adrenoceptors in the TMJ induces nociception mediated, at least in part, by the inflammatory response...
December 11, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29216534/thrombolytic-therapy-based-on-fucoidan-functionalized-polymer-nanoparticles-targeting-p-selectin
#14
Maya Juenet, Rachida Aid-Launais, Bo Li, Alice Berger, Joël Aerts, Véronique Ollivier, Antonino Nicoletti, Didier Letourneur, Cédric Chauvierre
Injection of recombinant tissue plasminogen activator (rt-PA) is the standard drug treatment for thrombolysis. However, rt-PA shows risk of hemorrhages and limited efficiency even at high doses. Polysaccharide-poly(isobutylcyanoacrylate) nanoparticles functionalized with fucoidan and loaded with rt-PA were designed to accumulate on the thrombus. Fucoidan has a nanomolar affinity for the P-selectin expressed by activated platelets in the thrombus. Solid spherical fluorescent nanoparticles with a hydrodynamic diameter of 136 ± 4 nm were synthesized by redox radical emulsion polymerization...
November 29, 2017: Biomaterials
https://www.readbyqxmd.com/read/29213185/crude-fucoidan-content-in-two-north-atlantic-kelp-species-saccharina-latissima-and-laminaria-digitata-seasonal-variation-and-impact-of-environmental-factors
#15
Annette Bruhn, Tina Janicek, Dirk Manns, Mette Møller Nielsen, Thorsten Johannes Skovbjerg Balsby, Anne S Meyer, Michael Bo Rasmussen, Xiaoru Hou, Bodo Saake, Cordula Göke, Anne Belinda Bjerre
Fucoidans are sulphated fucose-rich polysaccharides predominantly found in the cell walls of brown algae. The bioactive properties of fucoidans attract increasing interest from the medico-pharmaceutical industries and may drive an increase in demand of brown algae biomass. In nature, the biochemical composition of brown algae displays a seasonal fluctuation driven by environmental factors and endogenous rhythms. To cultivate and harvest kelps with high yields of fucoidans, knowledge is needed on seasonal variation and impact of environmental conditions on the fucoidan content of brown algae...
2017: Journal of Applied Phycology
https://www.readbyqxmd.com/read/29205092/biocompatibility-of-subcutaneously-implanted-marine-macromolecules-cross-linked-bio-composite-scaffold-for-cartilage-tissue-engineering-applications
#16
A S Sumayya, G Muraleedhara Kurup
There is an intense interest in developing innovative biomaterials which support the invasion and proliferation of living cells for potential applications in tissue engineering and regenerative medicine. Present study demonstrated the in vivo biocompatibility and toxicity of a macromolecules cross-linked biocomposite scaffold composed of hydroxyapatite, alginate, chitosan and fucoidan abbreviated as HACF. The in vivo biocompatibility and toxicity of HACF scaffold were tested by comparing them with those of a biocompatible surgical metal implant (SMI) in a subcutaneous rat model...
December 5, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/29173183/a-comparison-of-fucoidan-conjugated-to-paclitaxel-and-curcumin-for-the-dual-delivery-of-cancer-therapeutic-agents
#17
Nam Hoang Phan, Thao Thanh Ly, Minh Nguyet Pham, Thinh Duc Luu, Toi Van Vo, Phuong Ha-Lien Tran, Thao Truong-Dinh Tran
The aim of this study was to develop and compare polymeric micelles of fucoidan, a sulfated polysaccharide, and hydrophobic drugs such as paclitaxel and curcumin. Paclitaxel and curcumin are both known for their medicinal properties, including anticancer efficacy. However, their very low water solubility, absorption and rapid metabolism leads to reduced bioavailability. To redress these problems and enhance anti-cancer therapeutics using fucoidan, polymeric micelles were synthesized from conjugates of fucoidan and hydrophobic drugs...
November 21, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29156992/evaluation-fucoidan-extracts-from-undaria-pinnatifida-and-fucus-vesiculosus-in-combination-with-anticancer-drugs-in-human-cancer-orthotopic-mouse-models
#18
Maryam Burney, Lata Mathew, Anjali Gaikwad, Elizabeth K Nugent, Anneliese O Gonzalez, Judith A Smith
OBJECTIVE: To determine the activity of fucoidan from Undaria pinnatifida (UPF) and Fucus vesiculosus (FVF) when given in combination of chemotherapy drugs using selected human breast or ovarian cancer orthotopic mouse models. METHODS: Mice were inoculated with 1 × 10(6) cells of TOV-112d, MCF-7, or ZR-75 subcutaneously or SKOV3-GFP-Luc intraperitoneally on day 0. MCF-7 and ZR-75 mice were administered with estradiol valerate 2 mg/kg in 0.2 mL castor oil subcutaneously two days prior to cell inoculation...
November 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/29154963/macrophage-scavenger-receptor-1-contributes-to-pathogenesis-of-fulminant-hepatitis-via-neutrophil-mediated-complement-activation
#19
Yuan Tang, Huifang Li, Junru Li, Yunzhi Liu, Yanli Li, Jing Zhou, Jia Zhou, Xiao Lu, Wei Zhao, Jinlin Hou, Xiang-Yang Wang, Zhengliang Chen, Daming Zuo
BACKGROUND & AIMS: The macrophage scavenger receptor 1 (Msr1, also called SRA) is a pattern recognition receptor primarily expressed on myeloid cells, which plays an important role in the maintenance of immune homeostasis. Since MSR1 expression was upregulated in the livers of patients with fulminant hepatitis (FH), we investigated the functional mechanism of Msr1 in FH pathogenesis. METHODS: Msr1-deficient (Msr1-/-) mice and their wild-type (WT) littermates were infected with mouse hepatitis virus strain-A59 (MHV-A59) to induce FH, and the levels of tissue damage, serum alanine aminotransferase, inflammatory cytokines and complement component 5a (C5a) were measured and compared...
November 14, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/29141543/effects-of-fucoidan-and-chemotherapeutic-agent-combinations-on-malignant-and-non-malignant-breast-cell-lines
#20
Aisha Abudabbus, Jelili A Badmus, Salem Shalaweh, Rolene Bauer, Donavon Hiss
OBJECTIVES: Breast cancer is a leading cause of death among women in both developed and Third World countries. Fucoidan is a natural plant product produced by brown seaweeds with proven anticancer potential. This study determined the cytotoxic, apoptotic and cell cycle effects of fucoidan alone and in combination with first-line anticancer drugs (cisplatin, doxorubicin and taxol) in MCF-7 breast cancer cells and non-malignant MCF-12A breast epithelial cells as control. METHODS: Cytotoxicity was evaluated using the MTT reduction assay...
November 14, 2017: Current Pharmaceutical Biotechnology
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