keyword
MENU ▼
Read by QxMD icon Read
search

Fucoidan

keyword
https://www.readbyqxmd.com/read/28528951/polysaccharides-from-sargassum-thunbergii-monthly-variations-and-anti-complement-and-anti-tumour-activities
#1
Weihua Jin, Ge Liu, Weihong Zhong, Chaomin Sun, Quanbin Zhang
Monthly variations of polysaccharides from Sargassum thunbergii and their anti-complement and anti-tumour activities were investigated. It was observed that an increase in fucose and total sugar contents occurred during the growth period (from early April to mid-June), accompanied by a decrease in molar ratios of other monosaccharides to fucose. The highest yields were obtained from early July to early September, which was in accordance with the significant increase in molar ratio of glucose to fucose and decrease in molar ratio of other monosaccharides to fucose...
May 18, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28524785/development-of-genipin-crosslinked-fucoidan-chitosan-n-arginine-nanogels-for-preventing-helicobacter-infection
#2
Yu-Hsin Lin, Kun-Ying Lu, Ching-Li Tseng, Jui-Yu Wu, Chien-Ho Chen, Fwu-Long Mi
AIM: This study aims to validate the anti-Helicobacter pylori efficacy of amoxicillin-loaded nanoparticles and nanogels with pH-responsive and site-specific drug release properties against H. pylori infection. MATERIALS & METHODS: Genipin-crosslinked low molecular weight fucoidan/chitosan-N-arginine nanogels (FCSA) were prepared for targeted delivery of amoxicillin to the site of H. pylori infected AGS gastric epithelial cells. RESULTS: The negatively charged nanogels (n-FCSA) adhered to H...
May 19, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28522000/in-vitro-antioxidant-and-antibacterial-activity-of-sulfated-polysaccharides-isolated-from-spatoglossum-asperum
#3
Subramanian Palanisamy, Manoharan Vinosha, Thangapandi Marudhupandi, Periyannan Rajasekar, Narayanan Marimuthu Prabhu
Fucoidan was extracted productively from Spatoglossum asperum and its antioxidant and antibacterial potential against Aeromonos hydrophila was investigated. The isolated fucoidan was characterized by HPLC, FTIR, (1)H and (13)C NMR spectrum. The isolated fucoidan contained 60.9% fucose, 21.35±0.81% sulfate and 4.2±0.56% protein, respectively. The in vitro antioxidant activity was evaluated by DPPH radical scavenging, reducing power and total antioxidant activities. The extracted fucoidan showed antioxidant properties in a dose-dependent manner...
August 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28493611/fucoidan-ameliorates-pancreatic-%C3%AE-cell-death-and-impaired-insulin-synthesis-in-streptozotocin-treated-%C3%AE-cells-and-mice-via-a-sirt-1-dependent-manner
#4
Wen-Chun Yu, Yen-Lin Chen, Pai-An Hwang, Tso-Hsiao Chen, Tz-Chong Chou
SCOPE: Several beneficial biological functions of fucoidan (FO) isolated from brown algae have been demonstrated. The purpose of this study was to investigate whether FO derived from Sargassum hemiphyllum ameliorates pancreatic β-cell damage and impaired insulin synthesis under diabetic condition. METHODS AND RESULTS: The effects of FO were studied in streptozotocin (STZ)-treated pancreatic β-cell line, NIT-1cells, and mice. The cell apoptosis, protein analyses, histological examination, and pancreatic function assays were performed...
May 11, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28487956/differences-in-cell-death-and-cell-cycle-following-fucoidan-treatment-in-high-density-ht-29-colon-cancer-cells
#5
In-Hye Kim, Mi-Jin Kwon, Taek-Jeong Nam
Fucoidan, a sulfated polysaccharide present in marine brown seaweed, has been demonstrated to inhibit in vivo and in vitro growth of cells. The present study was conducted in HT‑29 human colon cancer cells cultured at a high density, and examined the potential underlying mechanisms by which fucoidan exerts its anti‑proliferative effects, which remain poorly understood. Fucoidan treatment of high‑density HT‑29 cells resulted in the inhibition of cell growth and increased apoptotic cell death. Flow cytometric analysis revealed that fucoidan treatment led to sub‑G1 phase cell cycle arrest...
June 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28482497/biomineralization-potential-and-cellular-response-of-phb-and-phbv-blends-with-natural-anionic-polysaccharides
#6
Nowsheen Goonoo, Archana Bhaw-Luximon, Pearl Passanha, Sandra Esteves, Holger Schönherr, Dhanjay Jhurry
In this paper, the biomineralization potential and cellular response of novel blend films of the anionic sulfated polysaccharides kappa-carrageenan (KCG) and fucoidan (FUC) derived from seaweeds with semi-crystalline polyhydroxybutyrate (PHB) and polyhydroxybutyrate-co-valerate (PHBV), respectively, were analyzed. The incorporation of KCG and FUC into PHB and PHBV, which has been studied here for the first time, led to an overall decrease in crystallinity, enhanced surface hydrophilicity, reduced brittleness and faster degradation of the polymer blend films...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28476987/phytochemical-constituents-of-fucoidan-padina-tetrastromatica-and-its-assisted-agnps-for-enhanced-antibacterial-activity
#7
S Rajeshkumar
Biological synthesis of nanomaterials is a growing innovative approach and it was broadly utilised in the field of nanotechnology and nanomedicine. This study illustrates that biosynthesis of silver nanoparticles (AgNPs) using fucoidan extracted from seaweed Padina tetrastromatica. The functional groups of extracted fucoidan were characterised by Fourier transform infrared spectroscopy (FTIR) and used to NPs synthesis. Synthesised AgNPs were characterised by ultraviolet-visible spectra, scanning electron microscope, energy dispersive X-ray, transmission electron microscope, selected area electron diffraction and FTIR...
April 2017: IET Nanobiotechnology
https://www.readbyqxmd.com/read/28447753/antitumor-activity-of-fucoidan-in-anaplastic-thyroid-cancer-via-apoptosis-and-anti-angiogenesis
#8
Hong-Yan Shen, Lan-Zhen Li, Ke-Cheng Xue, Dan-Dan Hu, Yu-Jun Gao
The present study demonstrated the effect of fucoidan, isolated from Fucus vesiculosus, on cell growth and apoptosis in anaplastic thyroid cancer cells. The cell viability was analyzed using a Cell Counting Kit‑8 cell proliferation kit. Diamidino-2-phenylindole and terminal deoxynucleotidyl transferase-mediated dUTP nick‑end labeling assays were used to examine the apoptotic effect of fucoidan, which revealed the presence of apoptotic bodies and DNA fragmentation. Fucoidan inhibited the growth of FTC133 and TPC1 ATC cells in a dose‑dependent manner...
May 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28442389/gene-identification-and-characterization-of-fucoidan-deacetylase-for-potential-application-to-fucoidan-degradation-and-diversification
#9
Tatsuhiko Nagao, Ayako Kumabe, Fumika Komatsu, Hisashi Yagi, Hirokazu Suzuki, Takashi Ohshiro
Fucoidan is an α-l-fucopyranosyl polymer found in seaweeds with forms that have acetyl and sulfuric modifications and derivatives that are lower and/or diversified, with modifications that have attracted interest as potential bioactive substances. We identified the gene for a fucoidan deacetylase that cleaves acetyl moieties from fucoidan and thereby contributes to fucoidan utilization in the marine bacterium Luteolibacter algae H18. Fucoidan deacetylase was purified to homogeneity from a cell-free extract of L...
April 22, 2017: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/28430159/efficacy-of-low-molecular-weight-fucoidan-as-a-supplemental-therapy-in-metastatic-colorectal-cancer-patients-a-double-blind-randomized-controlled-trial
#10
Hsiang-Lin Tsai, Chi-Jung Tai, Ching-Wen Huang, Fang-Rong Chang, Jaw-Yuan Wang
BACKGROUND: Low-molecular-weight fucoidan (LMF) is widely used as a food supplement for cancer patients. However, all of the studies are in vitro or were conducted using mice. Therefore, powerful clinical evidence for LMF use is relatively weak. This study aimed to evaluate the efficacy of LMF as a supplemental therapy to chemo-target agents in metastatic colorectal cancer (mCRC) patients. METHODS: We conducted a prospective, randomized, double-blind, controlled trial to evaluate the efficacy of LMF as a supplemental therapy to chemotarget agents in patients with metastatic colorectal cancer (mCRC)...
April 21, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28400184/isolation-of-fucoidan-from-sargassum-polycystum-brown-algae-structural-characterization-in-vitro-antioxidant-and-anticancer-activity
#11
Subramanian Palanisamy, Manoharan Vinosha, Thangapandi Marudhupandi, Periyannan Rajasekar, Narayanan Marimuthu Prabhu
In this study antioxidant and anticancer effect of fucoidan isolated from brown seaweed Sargassum polycystum was investigated. The total yield of fucoidan was 4.51±0.24%, of these, 46.8% of fucose and 22.35±0.23% of sulphate respectively. The structural characteristic of fucoidan was analyzed by Fourier transform infrared spectroscopy and nuclear magnetic resonance. The antioxidant properties were determined by DPPH scavenging, reducing power and total antioxidant assays. The maximum DPPH scavenging activity (61...
April 9, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28398713/anti-egfr-antibody-conjugation-of-fucoidan-coated-gold-nanorods-as-novel-photothermal-ablation-agents-for-cancer-therapy
#12
Panchanathan Manivasagan, Subramaniyan Bharathiraja, Madhappan Santha Moorthy, Yun-Ok Oh, Kyeongeun Song, Hansu Seo, Junghwan Oh
The development of novel photothermal ablation agents as cancer nanotheranostics has received a great deal of attention in recent decades. Biocompatible fucoidan (Fu) is used as the coating material for gold nanorods (AuNRs) and subsequently conjugated with monoclonal antibodies against epidermal growth factor receptor (anti-EGFR) as novel photothermal ablation agents for cancer nanotheranostics because of their excellent biocompatibility, biodegradability, nontoxicity, water solubility, photostability, ease of surface modification, strongly enhanced absorption in near-infrared (NIR) regions, target specificity, minimal invasiveness, fast recovery, and prevention of damage to normal tissues...
April 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28387741/effects-of-low-molecular-weight-fucoidan-and-high-stability-fucoxanthin-on-glucose-homeostasis-lipid-metabolism-and-liver-function-in-a-mouse-model-of-type-ii-diabetes
#13
Hong-Ting Victor Lin, Yu-Chi Tsou, Yu-Ting Chen, Wen-Jung Lu, Pai-An Hwang
The combined effects of low-molecular-weight fucoidan (LMF) and fucoxanthin (Fx) in terms of antihyperglycemic, antihyperlipidemic, and hepatoprotective activities were investigated in a mouse model of type II diabetes. The intake of LMF, Fx, and LMF + Fx lowered the blood sugar and fasting blood sugar levels, and increased serum adiponectin levels. The significant decrease in urinary sugar was only observed in LMF + Fx supplementation. LMF and Fx had ameliorating effects on the hepatic tissue of db/db mice by increasing hepatic glycogen and antioxidative enzymes, and LMF was more effective than Fx at improving hepatic glucose metabolism...
April 7, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28387729/promoting-wound-healing-using-low-molecular-weight-fucoidan-in-a-full-thickness-dermal-excision-rat-model
#14
Jun-Hyeong Park, Seong-Hun Choi, Soo-Jin Park, Young Joon Lee, Jong Hyun Park, Phil Hyun Song, Chang-Mo Cho, Sae-Kwang Ku, Chang-Hyun Song
Low molecular weight fucoidan (LMF) has been reported to possess anti-inflammatory and antioxidant activities. Thus, we examined the effects of LMF extracted from Undaria pinnatifida on dermal wounds. Five round dermal wounds were created on the dorsal back of rats, and they were then treated topically with distilled water (DW), Madecasol Care™ (MC) or LMF at 200, 100 and 50 mg/mL, twice a day for a week. There were dose-dependent increases in wound contraction in the groups receiving LMF but not in the MC group, compared with the DW...
April 7, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28363573/effects-of-fucoidans-and-heparin-on-reactions-of-neutrophils-induced-by-il-8-and-c5a
#15
Inga Liewert, Karina Ehrig, Susanne Alban
Fucose-containing sulfated polysaccharides (fucoidans) from brown algae exhibit anti-inflammatory activity in vivo, however, there is only limited knowledge about their mode of action. Potential targets may be the chemokine interleukin 8 (IL-8) and the anaphylatoxin C5a, as they are closely linked to inflammatory processes. In this study, two fucoidans from Saccharina latissima and Fucus vesiculosus, and unfractionated heparin (UFH) were examined for their binding properties to IL-8 and C5a and their effects on IL-8- and C5a-induced reactions of polymorphonuclear neutrophils (PMN)...
June 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28363567/development-of-a-new-type-of-multifunctional-fucoidan-based-nanoparticles-for-anticancer-drug-delivery
#16
Kun-Ying Lu, Rou Li, Chun-Hua Hsu, Cheng-Wei Lin, Shen-Chieh Chou, Min-Lang Tsai, Fwu-Long Mi
Fucoidan, a sulfated marine polysaccharide, has many potential biological functions, including anticancer activity. Recently, fucoidan has been reported to target P-selectin expressed on metastatic cancer cells. Increasing research attention has been devoted to the developments of fucoidan-based nanomedicine. However, the application of traditional chitosan/fucoidan nanoparticles in anticancer drug delivery may be limited due to the deprotonation of chitosan at a pH greater than 6.5. In this study, a mutli-stimuli-responsive nanoparticle self-assembled by fucoidan and a cationic polypeptide (protamine) was developed, and their pH-/enzyme-responsive properties were characterized by circular dichroism (CD) spectroscopy, dynamic light scattering (DLS), and zeta potential analysis...
June 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28332554/fucoidan-induces-toll-like-receptor-4-regulated-reactive-oxygen-species-and-promotes-endoplasmic-reticulum-stress-mediated-apoptosis-in-lung-cancer
#17
Hsien-Yeh Hsu, Tung-Yi Lin, Mei-Kuang Lu, Pei-Ju Leng, Shu-Ming Tsao, Yu-Chung Wu
Fucoidan, a sulfated polysaccharide extracted from brown algae, exhibits anti-cancer activity. However, the effects and mechanism of fucoidan-induced apoptosis via endoplasmic reticulum (ER) stress is unclear. In this study, we demonstrated that fucoidan prevents tumorigenesis and reduces tumor size in LLC1-xenograft male C57BL/6 mice. Fucoidan induces an ER stress response by activating the PERK-ATF4-CHOP pathway, resulting in apoptotic cell death in vitro and in vivo. Furthermore, ATF4 knockdown abolishes fucoidan-induced CHOP expression and rescues cell viability...
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28300775/protective-effects-of-fucoidan-on-a%C3%AE-25-35-and-d-gal-induced-neurotoxicity-in-pc12-cells-and-d-gal-induced-cognitive-dysfunction-in-mice
#18
Hengyun Wei, Zixiang Gao, Luping Zheng, Cuili Zhang, Zundong Liu, Yazong Yang, Hongming Teng, Lin Hou, Yuling Yin, Xiangyang Zou
Alzheimer's disease (AD) is a chronic neurodegenerative disease which contributes to memory loss and cognitive decline in the elderly. Fucoidan, extracted from brown algae, is a complex sulfated polysaccharide and potential bioactive compound. In this study, we investigated whether fucoidan protects PC12 cells from apoptosis induced by a combination of beta-amyloid 25-35 (Aβ25-35) and d-galactose (d-Gal), and improves learning and memory impairment in AD model mice. The results indicated that fucoidan could inhibit the release of cytochrome c from the mitochondria to cytosol and activation of caspases, and increase the expression of apoptosis inhibitor proteins (IAPs), including livin and X-linked IAP (XIAP) in PC12 cells damaged by Aβ25-35 and d-Gal-induction...
March 16, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28295751/the-role-of-plant-derived-products-in-pancreatitis-experimental-and-clinical-evidence
#19
REVIEW
Pratibha Anchi, Amit Khurana, Swarna Bale, Chandraiah Godugu
Pancreatitis is a gastrointestinal disease with a worldwide sharp surge during the past decade. Pancreatitis includes acute and chronic subtypes, which are graded based on the amount of pancreatic inflammation. Phytoconstituents represent a promising class of therapeutic agents with wide acceptability not only based on folk practices but sound presence of pharmacological and molecular evidences. Growing research evidence indicates that different molecular mechanisms are involved in their protective effect. Many phytoremedies have been tried for the treatment of pancreatic injuries and have shown success in preclinical animal models of pancreatitis...
April 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28287033/marine-macromolecules-cross-linked-hydrogel-scaffolds-as-physiochemically-and-biologically-favorable-entities-for-tissue-engineering-applications
#20
A S Sumayya, G Muraleedhara Kurup
Marine biopolymer composite materials provide a technological platform for launching biomedical applications. Biomaterials demand good biocompatibility without the possibility of inflammation or foreign body reactions. In this study, we prepared two biocomposite hydrogels namely; HAC (hydroxyapatite, alginate & chitosan) and HACF (hydroxyapatite, alginate, chitosan & fucoidan) followed by calcium chloride cross linking. The prepared scaffolds were characterized by Fourier transform infrared spectroscopy and scanning electron microscopy...
June 2017: Journal of Biomaterials Science. Polymer Edition
keyword
keyword
17536
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"