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Fucoidan

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https://www.readbyqxmd.com/read/28300775/protective-effects-of-fucoidan-on-a%C3%AE-25-35-and-d-gal-induced-neurotoxicity-in-pc12-cells-and-d-gal-induced-cognitive-dysfunction-in-mice
#1
Hengyun Wei, Zixiang Gao, Luping Zheng, Cuili Zhang, Zundong Liu, Yazong Yang, Hongming Teng, Lin Hou, Yuling Yin, Xiangyang Zou
Alzheimer's disease (AD) is a chronic neurodegenerative disease which contributes to memory loss and cognitive decline in the elderly. Fucoidan, extracted from brown algae, is a complex sulfated polysaccharide and potential bioactive compound. In this study, we investigated whether fucoidan protects PC12 cells from apoptosis induced by a combination of beta-amyloid 25-35 (Aβ25-35) and d-galactose (d-Gal), and improves learning and memory impairment in AD model mice. The results indicated that fucoidan could inhibit the release of cytochrome c from the mitochondria to cytosol and activation of caspases, and increase the expression of apoptosis inhibitor proteins (IAPs), including livin and X-linked IAP (XIAP) in PC12 cells damaged by Aβ25-35 and d-Gal-induction...
March 16, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28295751/the-role-of-plant-derived-products-in-pancreatitis-experimental-and-clinical-evidence
#2
REVIEW
Pratibha Anchi, Amit Khurana, Swarna Bale, Chandraiah Godugu
Pancreatitis is a gastrointestinal disease with a worldwide sharp surge during the past decade. Pancreatitis includes acute and chronic subtypes, which are graded based on the amount of pancreatic inflammation. Phytoconstituents represent a promising class of therapeutic agents with wide acceptability not only based on folk practices but sound presence of pharmacological and molecular evidences. Growing research evidence indicates that different molecular mechanisms are involved in their protective effect. Many phytoremedies have been tried for the treatment of pancreatic injuries and have shown success in preclinical animal models of pancreatitis...
March 15, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28287033/marine-macromolecules-cross-linked-hydrogel-scaffolds-as-physiochemically-and-biologically-favorable-entities-for-tissue-engineering-applications
#3
Muraleedhara Kurup G, Sumayya A S
Marine biopolymer composite materials provide a technological platform for launching biomedical applications. Biomaterials demand good biocompatibility without the possibility of inflammation or foreign body reactions. In this study, we prepared two biocomposite hydrogels namely; HAC (hydroxyapatite, alginate & chitosan) and HACF (hydroxyapatite, alginate, chitosan & fucoidan) followed by calcium chloride cross linking. The prepared scaffolds were characterized by Fourier Transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM)...
March 11, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28276640/prospective-review-of-mesenchymal-stem-cells-differentiation-into-osteoblasts
#4
REVIEW
Priyanka Garg, Matthew M Mazur, Amy C Buck, Meghan E Wandtke, Jiayong Liu, Nabil A Ebraheim
Stem cell research has been a popular topic in the past few decades. This review aims to discuss factors that help regulate, induce, and enhance mesenchymal stem cell (MSC) differentiation into osteoblasts for bone regeneration. The factors analyzed include bone morphogenic protein (BMP), transforming growth factor β (TGF-β), stromal cell-derived factor 1 (SDF-1), insulin-like growth factor type 1 (IGF-1), histone demethylase JMJD3, cyclin dependent kinase 1 (CDK1), fucoidan, Runx2 transcription factor, and TAZ transcriptional coactivator...
March 9, 2017: Orthopaedic Surgery
https://www.readbyqxmd.com/read/28259971/fucoidan-modulates-cytokine-production-and-migration-of-thp%C3%A2-1%C3%A2-derived-macrophages-via-colony%C3%A2-stimulating-factor%C3%A2-1
#5
Peng Li, Huayang Wang, Qianqian Shao, Beihua Kong, Xun Qu
Fucoidan is known for its various biological activities, including immunomodulatory effects on immune cells. However, the effect of fucoidan on the functions of macrophages remains to be elucidated. The present study examined the effects of fucoidan on cytokine production and migration of THP‑1‑derived macrophages and its potential mechanisms. Fucoidan was added during the differentiation process of THP‑1‑derived macrophages along with lipopolysaccharide and interferon‑γ for 42 h, and then macrophages were harvested for functional assays...
February 22, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28230794/structural-determinant-and-its-underlying-molecular-mechanism-of-stpc2-related-to-anti-angiogenic-activity
#6
Min Hu, Ning Cui, Zhixiang Bo, Feixiang Xiang
In this study, we aimed to use different strategies to further uncover the anti-angiogenic molecular mechanism of a fucoidan-like polysaccharide STPC2, isolated from brown alga Sargassum thunbergii. A desulfated derivative, STPC2-DeS, was successfully prepared and identified. The native polysaccharide and desulfated product were subjected to evaluate their anti-angiogenic effects. In the tube formation assay, STPC2 showed dose-dependent inhibition. In addition, STPC2 could distinctly inhibit the permeation of HUVEC cells into the lower chamber...
February 21, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28194259/anti-inflammatory-activity-of-a-sulfated-polysaccharide-isolated-from-an-enzymatic-digest-of-brown-seaweed-sargassum-horneri-in-raw-264-7-cells
#7
Kalu Kapuge Asanka Sanjeewa, Ilekkuttige Priyan Shanura Fernando, Eun-A Kim, Ginnae Ahn, Youngheun Jee, You-Jin Jeon
BACKGROUND/OBJECTIVES: Sargassum horneri is an edible brown alga that grows in the subtidal zone as an annual species along the coasts of South Korea, China, and Japan. Recently, an extreme amount of S. horneri moved into the coasts of Jeju Island from the east coast of China, which made huge economic and environmental loss to the Jeju Island. Thus, utilization of this biomass becomes a big issue with the local authorities. Therefore, the present study was performed to evaluate the anti-inflammatory potential of crude polysaccharides (CPs) extracted from S...
February 2017: Nutrition Research and Practice
https://www.readbyqxmd.com/read/28190419/seaweed-extracts-and-galacto-oligosaccharides-improve-intestinal-health-in-pigs-following-salmonella-typhimurium-challenge
#8
M A Bouwhuis, M J McDonnell, T Sweeney, A Mukhopadhya, C J O'Shea, J V O'Doherty
Pork and pork products are recognised as vehicles of Salmonella Typhimurium infection in humans. Seaweed-derived polysaccharides (SWE) and galacto-oligosaccharides (GOS) have shown to exhibit antimicrobial, prebiotic and immunomodulatory activity. The objective of this study was to assess the effects of dietary GOS and SWE supplementation on reducing S. Typhimurium numbers and intestinal inflammation in vivo. In total, 30 pigs (n=10/treatment, BW 30.9 kg) were randomly assigned to three dietary treatments: (1) basal diet; (2) basal diet+2...
February 13, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28106881/phylogenomics-of-rhodobacteraceae-reveals-evolutionary-adaptation-to-marine-and-non-marine-habitats
#9
Meinhard Simon, Carmen Scheuner, Jan P Meier-Kolthoff, Thorsten Brinkhoff, Irene Wagner-Döbler, Marcus Ulbrich, Hans-Peter Klenk, Dietmar Schomburg, Jörn Petersen, Markus Göker
Marine Rhodobacteraceae (Alphaproteobacteria) are key players of biogeochemical cycling, comprise up to 30% of bacterial communities in pelagic environments and are often mutualists of eukaryotes. As 'Roseobacter clade', these 'roseobacters' are assumed to be monophyletic, but non-marine Rhodobacteraceae have not yet been included in phylogenomic analyses. Therefore, we analysed 106 genome sequences, particularly emphasizing gene sampling and its effect on phylogenetic stability, and investigated relationships between marine versus non-marine habitat, evolutionary origin and genomic adaptations...
January 20, 2017: ISME Journal
https://www.readbyqxmd.com/read/28104371/in-vitro-and-in-vivo-evaluation-of-anti-arthritic-antioxidant-efficacy-of-fucoidan-from-undaria-pinnatifida-harvey-suringar
#10
Abdul-Rehman Phull, Muhammad Majid, Ihsan-Ul Haq, Muhammad Rashid Khan, Song Ja Kim
Seaweed and their constituents have been traditionally employed for the management of various human pathologic conditions such as edema, urinary disorders and inflammatory anomalies. The current study was performed to investigate the antioxidant and anti-arthritic effects of fucoidan from Undaria pinnatifida. A noteworthy in vitro antioxidant potential at 500μg/ml in 2, 2-diphenyl-1-picrylhydrazyl scavenging assay (80% inhibition), nitrogen oxide inhibition assay (71.83%), hydroxyl scavenging assay (71.92%), iron chelating assay (73...
April 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28098144/oligo-fucoidan-prevents-renal-tubulointerstitial-fibrosis-by-inhibiting-the-cd44-signal-pathway
#11
Cheng-Hsien Chen, Yuh-Mou Sue, Chung-Yi Cheng, Yen-Cheng Chen, Chung-Te Liu, Yung-Ho Hsu, Pai-An Hwang, Nai-Jen Huang, Tso-Hsiao Chen
Tubulointerstitial fibrosis is recognized as a key determinant of progressive chronic kidney disease (CKD). Fucoidan, a sulphated polysaccharide extracted from brown seaweed, exerts beneficial effects in some nephropathy models. The present study evaluated the inhibitory effect of oligo-fucoidan (800 Da) on renal tubulointerstitial fibrosis. We established a mouse CKD model by right nephrectomy with transient ischemic injury to the left kidney. Six weeks after the surgery, we fed the CKD mice oligo-fucoidan at 10, 20, and 100 mg/kg/d for 6 weeks and found that the oligo-fucoidan doses less than 100 mg/kg/d improved renal function and reduced renal tubulointerstitial fibrosis in CKD mice...
January 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28094330/inhibition-of-influenza-a-virus-infection-by-fucoidan-targeting-viral-neuraminidase-and-cellular-egfr-pathway
#12
Wei Wang, Jiandong Wu, Xiaoshuang Zhang, Cui Hao, Xiaoliang Zhao, Guangling Jiao, Xindi Shan, Wenjing Tai, Guangli Yu
Development of novel anti-influenza A virus (IAV) drugs with high efficiency and low toxicity is critical for preparedness against influenza outbreaks. Herein, we investigated the anti-IAV activities and mechanisms of fucoidan in vitro and in vivo. The results showed that a fucoidan KW derived from brown algae Kjellmaniella crassifolia effectively blocked IAV infection in vitro with low toxicity. KW possessed broad anti-IAV spectrum and low tendency of induction of viral resistance, superior to the anti-IAV drug amantadine...
January 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28060735/the-natural-compound-fucoidan-from-new-zealand-undaria-pinnatifida-synergizes-with-the-erbb-inhibitor-lapatinib-enhancing-melanoma-growth-inhibition
#13
Varsha Thakur, Jun Lu, Giuseppe Roscilli, Luigi Aurisicchio, Manuela Cappelletti, Emiliano Pavoni, William Lindsey White, Barbara Bedogni
Melanoma remains one of the most aggressive and therapy-resistant cancers. Finding new treatments to improve patient outcomes is an ongoing effort. We previously demonstrated that melanoma relies on the activation of ERBB signaling, specifically of the ERBB3/ERBB2 cascade. Here we show that melanoma tumor growth is inhibited by 60% over controls when treated with lapatinib, a clinically approved inhibitor of ERBB2/EGFR. Importantly, tumor growth is further inhibited to 85% when the natural compound fucoidan from New Zealand U...
January 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28035379/antinociceptive-effects-of-fucoidan-in-rat-models-of-vincristine-induced-neuropathic-pain
#14
Chuanyin Hu, Yun-Tao Zhao, Guoping Zhang, Ming-Feng Xu
Chemotherapeutic drugs commonly induce peripheral neuropathic pain, which limit their clinic use. In the present study, the effect of fucoidan on the development of vincristine‑induced neuropathic pain was evaluated and the underlying mechanism was examined. A neuropathy model was established in Sprague‑Dawley rats by intraperitoneal injection of vincristine sulfate 50 µg/kg once a day for 10 consecutive days. Fucoidan (50, 100 or 200 mg/kg.) and pregabalin (10 mg/kg) were injected for 14 consecutive days...
February 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28031251/expression-and-biochemical-characterization-and-substrate-specificity-of-the-fucoidanase-from-formosa-algae
#15
Artem S Silchenko, Nadezhda E Ustyuzhanina, Mikhail I Kusaykin, Vadim B Krylov, Alexander S Shashkov, Andrey S Dmitrenok, Roza V Usoltseva, Anastasiya O Zueva, Nikolay E Nifantiev, Tatyana N Zvyagintseva
A gene that encodes fucoidanase ffa2 in the marine bacterium Formosa algae strain KMM 3553(T) was cloned, and the protein (FFA2) was produced in Escherichia coli Recombinant fucoidanase FFA2 was purified, and the biochemical properties of this enzyme were studied. The amino acid sequence of FFA2 showed 57% identity with known fucoidanase FcnA from Mariniflexile fucanivorans. The mass of the gene product FFA2 is 101.2 kDa (918 amino acid residues). Sequence analysis has revealed that fucoidanase FFA2 belongs to the GH107 (CAZy) family...
December 28, 2016: Glycobiology
https://www.readbyqxmd.com/read/28008779/the-effect-of-undaria-pinnatifida-fucoidan-on-the-pharmacokinetics-of-letrozole-and-tamoxifen-in-patients-with-breast-cancer
#16
Shreya Tocaciu, Lesley J Oliver, Ray M Lowenthal, Gregory M Peterson, Rahul Patel, Madhur Shastri, Georgia McGuinness, Inger Olesen, J Helen Fitton
BACKGROUND: Although the use of complementary and alternative medicines is widespread in cancer patients, clinical evidence of their benefits is sparse. Furthermore, while they are often assumed to be safe with regard to concurrent use of anticancer therapies, few studies have been carried out to investigate possible interactions. Fucoidans are a group of sulfated carbohydrates, derived from marine brown algae, which have long been used as dietary supplements due to their reported medicinal properties, including anticancer activity...
December 1, 2016: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/28004293/fucoidan-reduced-the-invasion-of-oral-squamous-cell-carcinoma-cells-and-modified-their-effects-to-macrophages
#17
Junda Lin, Ketao Wang, Huayang Wang, Qianqian Shao, Yijun Luan, Yan Xu, Xiaobin Song, Wanye Tan, Shaohua Liu, Fengcai Wei, Xun Qu
Fucoidan is a complex of polysaccharides showing antitumor and immunomodulation properties. Our previous studies found its regulation to myeloid immune cells, including macrophages. Aberrant infiltration and functions of macrophages are commonly found in oral squamous cell carcinoma (OSCC). In this study, we analyzed the effects of fucoidan on invasion of OSCC cells, and their regulation to macrophages, trying to evaluate its role as a potential therapy for OSCC. CAL27 and THP-1-derived macrophages were used as models for OSCC cells and tumor-infiltrated macrophages in the in vitro study, respectively...
January 2017: Medical Oncology
https://www.readbyqxmd.com/read/28000877/low%C3%A2-molecular-weight-fucoidan-inhibits-the-differentiation-of-osteoclasts-and-reduces-osteoporosis-in-ovariectomized-rats
#18
Xin Jin, Liguo Zhu, Xiulan Li, Jian Jia, Yang Zhang, Xiaolei Sun, Jianxiong Ma, Zhaojie Liu, Xinlong Ma
Fucoidan is a type of sulfated polysaccharide isolated from seaweed. The present study used ovariectomized Sprague‑Dawley rats, which were treated with fucoidan. The effects of fucoidan on bone metabolism, density and microarchitecture were assessed using micro‑computed tomography (CT), histomorphometric analysis, biochemical markers of bone metabolism (Serum procollagen type I N propeptide and C‑terminal telopeptide‑1) and tests of mechanical competence of the femur. In addition, the effects of low‑molecular weight fucoidan (LMWF) on in vitro cultured osteoclasts were examined, in order to determine the mechanisms underlying LMWF‑induced osteoclastic inhibition...
February 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27996198/the-key-role-of-sulfation-and-branching-on-fucoidan-antitumor-activity
#19
Catarina Oliveira, Andreia S Ferreira, Ramon Novoa-Carballal, Cláudia Nunes, Iva Pashkuleva, Nuno M Neves, Manuel A Coimbra, Rui L Reis, Albino Martins, Tiago H Silva
There is an urgent need for antitumor bioactive agents with minimal or no side effects over normal adjacent cells. Fucoidan is a marine-origin polymer with known antitumor activity. However, there are still some concerns about its application due to the inconsistent experimental results, specifically its toxicity over normal cells and the mechanism behind its action. Herein, three fucoidan extracts (FEs) have been tested over normal and breast cancer cell lines. From cytotoxicity results, only one of the extracts shows selective antitumor behavior (at 0...
December 20, 2016: Macromolecular Bioscience
https://www.readbyqxmd.com/read/27994679/brown-seaweed-fucoidan-inhibits-cancer-progression-by-dual-regulation-of-mir-29c-adam12-and-mir-17-5p-pten-axes-in-human-breast-cancer-cells
#20
Szu-Yuan Wu, Alexander T H Wu, Kevin Sheng-Po Yuan, Shing Hwa Liu
In this study, we observed that brown seaweed fucoidan inhibited human breast cancer progression by upregulating microRNA (miR)-29c and downregulating miR-17-5p, thereby suppressing their target genes, a disintegrin and metalloproteinase 12 (ADAM12) and phosphatase and tensin homolog (PTEN), respectively. Moreover, fucoidan reduced the luciferase activity of 3'-untranslated region reporter; treatment of cells with the miR-29c mimic or miR-17-5p inhibitor also produced similar results. These effects of fucoidan inhibited the epithelial-mesenchymal transition in breast cancer cells, as evidenced by an increase in E-cadherin and a drop in N-cadherin, and inhibited breast cancer cell survival, as evidenced by the activation of the phosphoinositide 3-kinase/Akt pathway...
2016: Journal of Cancer
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