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Fucoidan

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https://www.readbyqxmd.com/read/29141543/effects-of-fucoidan-and-chemotherapeutic-agent-combinations-on-malignant-and-non-malignant-breast-cell-lines
#1
Aisha Abudabbus, Jelili A Badmus, Salem Shalaweh, Rolene Bauer, Donavon Hiss
OBJECTIVES: Breast cancer is a leading cause of death among women in both developed and Third World countries. Fucoidan is a natural plant product produced by brown seaweeds with proven anticancer potential. This study determined the cytotoxic, apoptotic and cell cycle effects of fucoidan alone and in combination with first-line anticancer drugs (cisplatin, doxorubicin and taxol) in MCF-7 breast cancer cells and non-malignant MCF-12A breast epithelial cells as control. METHODS: Cytotoxicity was evaluated using the MTT reduction assay...
November 14, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29138822/fucoidan-inhibits-ca2-responses-induced-by-a-wide-spectrum-of-agonists-for-g%C3%A2-protein%C3%A2-coupled-receptors
#2
Hong Wu, Shuibo Gao, Min Fu, Takashi Sakurai, Susumu Terakawa
Fucoidan, a sulfated polysaccharide extracted from brown seaweed, has been used in traditional Chinese herbal medicine to treat thyroid tumors for many years. Although a number of its cellular effects have been investigated, the role of fucoidan in molecular signaling, particularly in Ca2+ signaling, remains largely unknown. In the present study, the effects of fucoidan on Ca2+ responses in HeLa cells, human umbilical vein endothelial cells and astrocytes were investigated using a wide range of receptor agonists...
November 13, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29138816/protective-effects-of-fucoidan-against-hyperoxic-lung-injury-via-the-erk-signaling-pathway
#3
Minghao Nie, Yan Wang, Yanhong Lu, Ying Yuan, Yingying Liu, Xiurong Li
High oxygen mechanical ventilation is widely used to treat various lung diseases; however, it may result in hyperoxia, which induces inflammation and lung injury. Fucoidan is an extract of the seaweed Fucus vesiculosus, which has previously been reported to exert effects against diabetic nephropathy. The present study is the first, to the best of our knowledge, to investigate the protective effects of fucoidan against hyperoxic lung injury. Balb/c mice were ventilated with 100% oxygen, with or without the atomization inhalation of fucoidan, for 36 h...
November 10, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29128704/tandem-mass-spectrometry-of-fucoidan-derived-fragments-labeled-with-heavy-oxygen
#4
Stanislav D Anastyuk, Natalia M Shevchenko, Kristina V Belokozova, Pavel S Dmitrenok
A procedure for the partial depolymerization of sulfated fucans and selective labeling with (18)O was developed. A tandem electrospray ionization mass spectrometry (ESI MS/MS) was applied for the direct analysis of mixtures of structurally-different oligosaccharides, derived from the fucoidans of known structure. The presence of label allowed unambiguous distinguishing between the fragment ions of (0,2)X0-type at m/z 287 and (2,4)A-type at m/z 285, since (18)O at the reducing end gave +2 mass shifting. Thus, ESI MS/MS was able to detect (1,2)-type of linkage in disaccharides from the fucoidan of brown alga S...
November 4, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/29121706/protective-effect-of-fucoidan-extract-from-ecklonia-cava-on-hydrogen-peroxide-induced-neurotoxicity
#5
Seon Kyeong Park, Jin Yong Kang, Jong Min Kim, Sang Hyun Park, Bong Seok Kwon, Gun-Hee Kim, Ho Jin Heo
We evaluated the antioxidant activity and neuronal cell-protective effect of fucoidan extract from Ecklonia cava (FEC) on hydrogen peroxide (H2O2)-induced cytotoxicity in PC-12 and MC-IXC cells to assess its protective effect against oxidative stress. Antioxidant activities were examined using the ABTS radical scavenging activity and malondialdehyde (MDA)-inhibitory effect, and the results showed that FEC had significant antioxidant activity. Intracellular ROS content and neuronal cell viability were investigated using DCF-DA assay and MTT reduction assay...
November 9, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29104632/fucoidan-elevates-surface-organic-cation-transporter-2-expression-via-upregulation-of-protein-kinase-a-in-uric-acid-nephropathy
#6
Xinlin Wu, Miansheng Yan, Taoli Liu, Jiantang Liao, Jianqing Zhang, Shuqing Chen, Wei Deng, Shijun Zhang, Baoguo Sun, Houming Zhou, Bin Ke
Uric acid nephropathy (UAN) is caused by excessive uric acid, and is a key risk factor for uric acid nephrolithiasis, gouty arthritis, renal diseases and cardiovascular diseases. The present study aimed to evaluate the protective effect of fucoidan, a sulfated polysaccharide component of brown algae, on UAN and to elucidate the underlying molecular mechanism. A rat model of UAN was induced by adenine treatment, and rats were then randomly assigned to control, model or fucoidan treatment groups. Hematoxylin and eosin staining of the kidney tissues of rats with UAN was subjected to conventional morphological evaluation...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29103498/structure-and-anticancer-activity-of-native-and-modified-polysaccharides-from-brown-alga-dictyota-dichotoma
#7
Roza V Usoltseva, Natalia M Shevchenko, Olesya S Malyarenko, Irina A Ishina, Svetlana I Ivannikova, Svetlana P Ermakova
The laminaran DdL and fucoidan DdF were obtained from the brown alga Dictyota dichotoma. DdF was a sulfated (28.9%) and acetylated heteropolysaccharide containing fucose, galactose, mannose and glucose (57.9, 20.4, 12.4 and 9.2mol%, respectively). DdL was a 1,3;1,6-β-d-glucan with the main chain built from 1,3-linked glucose residues and single glucose residue in branches at C6 (one branch on three glucose residues of the main chain). Sulfated (43.7%) laminaran DdLs was obtained from DdL by sulfation. It was determined that sulfates occur at C2, C4 and C6 of glucose residues...
January 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29096568/preclinical-evaluation-of-safety-of-fucoidan-extracts-from-undaria-pinnatifida-and-fucus-vesiculosus-for-use-in-cancer-treatment
#8
Lata Mathew, Maryam Burney, Anjali Gaikwad, Pranavand Nyshadham, Elizabeth K Nugent, Anneliese Gonzalez, Judith A Smith
OBJECTIVES: To evaluate potential hepatic metabolism-mediated drug interactions with fucoidan from Undaria pinnatifida (UPF) or Fucus vesiculosus (FVF) and potential growth inhibition activity with either fucoidan alone or with chemotherapy. In vivo studies were done to confirm safety and investigate fucoidan-mediated immune modulation. METHODS: Cytochrome P450 (CYP450) 3A4, 2C8, 2C9, and 2D6 inhibition experiments were conducted in vitro followed by an ex vivo human hepatocytes model to evaluate the CYP450 induction potential of each fucoidan at highest theoretical concentrations...
December 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/29061783/fucoidans-stimulate-immune-reaction-and-suppress-cancer-growth
#9
Vaclav Vetvicka, Jana Vetvickova
BACKGROUND/AIM: Fucoidans are gaining popularity as natural immunomodulators. The aim of this study was to compare the immunological activities or both purified samples and commercially available mixtures containing fucoidan. MATERIALS AND METHODS: We evaluated the effects of various samples on phagocytosis, mitogenic response, natural killer (NK) activity, antibody formation and inhibition of breast cancer growth. RESULTS: We found significant immunostimulating activity, but the strength of these effects was different among individual samples...
November 2017: Anticancer Research
https://www.readbyqxmd.com/read/29056467/gold-laced-bio-macromolecules-for-theranostic-application
#10
REVIEW
Pranjali Yadav, Surya Prakash Singh, Aravind Kumar Rengan, Asifkhan Shanavas, Rohit Srivastava
Gold nanostructures are promising entities for various biomedical applications, due to their promising physical and optical properties. They can be tailored in different sizes and shapes to play vital roles for photothermal therapy, Biosensing, In vivo X-ray/CT contrast etc. Many biomacromolecules have been used for chemical reduction of ionic gold into zero-valent metallic nanoparticles of specific shape/size followed by stabilizing them for long term utilization. This review will sum up a range of biomacromolecules including Alginate, Agarose, Starch, Carragenan, Cellulose, Chitin, Chitosan, Collagen, Cyclodextrins, Chondrotin Sulfate, Dextran Sulfate, Fucoidan, Gelatin, Guar Gum and Hyaluronic Acid, whose functionalities have been explored in combination with gold nanoparticles for various biomedical applications...
October 19, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29055704/comparative-study-of-the-effect-of-different-fucoidans-from-sargassum-maclurei-and-saccharina-japonica-on-fgfs-fgfr-signaling-activation-in-baf3-cells
#11
Lihua Geng, Ningning Hou, Meng Zhang, Yingjie Xu, Qi Zhang, Jing Wang, Lijuan Zhang, Quanbin Zhang
Different sulfated polysaccharides have distinct abilities to activate specific fibroblast growth factor (FGF) signaling pathways in FGFR1c-expressing BaF3 cells. In the current study, we first isolated and characterized different fucoidan fractions from Sargassum maclurei and Saccharina japonica. All of the fucoidan fractions were incubated with BaF3 cells in the presence of FGF-1, -2, -7, -8, -9, and -10, respectively, to evaluate their FGFs/FGFR1c signal-activating ability. Our data showed that low molecular weight fucoidan fraction from S...
October 18, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29048633/in%C3%A2-vitro-and-in%C3%A2-vivo-anti-primary-effusion-lymphoma-activities-of-fucoidan-extracted-from-cladosiphon-okamuranus-tokida
#12
Chie Ishikawa, Naoki Mori
Primary effusion lymphoma (PEL) caused by Kaposi's sarcoma-associated herpesvirus (KSHV) is characterized by lymphomatous effusion in body cavities and poor prognosis. There is still no effective treatment for PEL. Fucoidan, a major sulfated polysaccharide isolated from brown seaweeds, has an attractive array of bioactivities such as cancer inhibition. However, the effects of fucoidan on PEL cells remain unclear. We investigated the anti-PEL effects of fucoidan obtained from Cladosiphon okamuranus Tokida cultivated in Okinawa...
September 20, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29043842/the-protective-and-immunomodulatory-effects-of-fucoidan-against-7-12-dimethyl-benz-a-anthracene-induced-experimental-mammary-carcinogenesis-through-the-pd1-pdl1-signaling-pathway-in-rats
#13
Meilan Xue, Hui Liang, Qingjuan Tang, Chuanxing Xue, Xinjia He, Li Zhang, Zheng Zhang, Zhengyan Liang, Kang Bian, Lichen Zhang, Zhuxin Li
Fucoidan is a sulfated polysaccharide that is extracted from brown algae seaweed. This study was designed to evaluate the protective and immunomodulatory effects of dietary fucoidan on 7,12-dimethyl benz[a]anthracene (DMBA)-induced experimental mammary carcinogenesis in rats. Sixty Sprague-Dawley rats were randomly assigned to four equal groups: the control group (control group), the cancer model group (model group), and the F1 and F2 groups, which were fed fucoidan at concentrations of 200 and 400 mg/kg·body weight, respectively...
October 18, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/29036882/biomineralization-of-fucoidan-peptide-blends-and-their-potential-applications-in-bone-tissue-regeneration
#14
Harrison T Pajovich, Ipsita A Banerjee
Fucoidan (Fuc), a natural polysaccharide derived from brown seaweed algae, and gelatin (Gel) were conjugated to form a template for preparation of biomimetic scaffolds for potential applications in bone tissue regeneration. To the Fuc-Gel we then incorporated the peptide sequence MTNYDEAAMAIASLN (MTN) derived from the E-F hand domain, known for its calcium binding properties. To mimic the components of the extracellular matrix of bone tissue, the Fuc-Gel-MTN assemblies were incubated in simulated body fluid (SBF) to induce biomineralization, resulting in the formation of β-tricalcium phosphate, and hydroxyapatite (HAp)...
September 20, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29027361/magnetic-molecularly-imprinted-polymers-for-recognition-and-enrichment-of-polysaccharides-from-seaweed
#15
Guizhen Li, Kyung Ho Row
New magnetic molecularly imprinted polymers with two templates were fabricated for recognition of polysaccharides (fucoidan and alginic acid) from seaweed by magnetic solid-phase extraction, and the materials were modified by seven types of deep eutectic solvents. It was found that the deep eutectic solvents magnetic molecularly imprinted polymers showed stronger recognition and higher recoveries for fucoidan and alginic acid than magnetic molecularly imprinted polymers, and the deep eutectic solvents-4-magnetic molecularly imprinted polymers had the best effects...
October 12, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28973980/fucoidan-and-fucosylated-chondroitin-sulfate-stimulate-hematopoiesis-in-cyclophosphamide-induced-mice
#16
Natalia Anisimova, Nadezhda Ustyuzhanina, Maria Bilan, Fedor Donenko, Anatolii Usov, Mikhail Kiselevskiy, Nikolay Nifantiev
Application of cytostatics in cancer patients' chemotherapy results in a number of side effects, including the inhibition of various parts of hematopoiesis. Two sulfated polysaccharides, fucoidan from the seaweed Chordaria flagelliformis (PS-Fuc) and fucosylated chondroitin sulfate from the sea cucumber Massinium magnum (PS-FCS), were studied as stimulators of hematopoiesis after cyclophosphamide immunosuppression in mice. Recombinant granulocyte colony-stimulating factor (r G-CSF) was applied as a reference...
September 30, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28962791/the-potential-of-brown-algae-polysaccharides-for-the-development-of-anticancer-agents-an-update-on-anticancer-effects-reported-for-fucoidan-and-laminaran
#17
REVIEW
K K Asanka Sanjeewa, Jung-Suck Lee, Won-Suck Kim, You-Jin Jeon
In recent decades, attention to cancer-preventive treatments and studies on the development of anticancer drugs have sharply increased owing to the increase in cancer-related death rates in every region of the world. However, due to the adverse effects of synthetic drugs, much attention has been given to the development of anticancer drugs from natural sources because of fewer side effects of natural compounds than those of synthetic drugs. Recent studies on compounds and crude extracts from marine algae have shown promising anticancer properties...
December 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28928376/oligo-fucoidan-prevents-il-6-and-ccl2-production-and-cooperates-with-p53-to-suppress-atm-signaling-and-tumor-progression
#18
Li-Mei Chen, Po-Yen Liu, Yen-An Chen, Hong-Yu Tseng, Pei-Chun Shen, Pai-An Hwang, Hsin-Ling Hsu
Low-molecular-weight Fucoidan (Oligo-Fucoidan) is a sulfated polysaccharide that has a variety of biological effects and has also been shown to have beneficial health effects. However, the molecular mechanisms underlying the therapeutic effects of Oligo-Fucoidan in patients with cancer remain unclear. Using human colorectal cancer HCT116 cells with (p53(+/+)) or without (p53(-/-)) normal p53 expression, we found that Oligo-Fucoidan treatment reduces the occurrence of spontaneous DNA lesions. Etoposide induces double strand DNA breaks...
September 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28922635/fucoidan-coated-ciprofloxacin-loaded-chitosan-nanoparticles-for-the-treatment-of-intracellular-and-biofilm-infections-of-salmonella
#19
Elbi S, Nimal T R, Rajan V K, Gaurav Baranwal, Raja Biswas, Jayakumar R, Sathianarayanan S
Salmonella infections and their gallstone associated biofilm infections are difficult to treat due to poor penetration of antibiotics into the intracellular compartments of macrophages and within biofilms. Here we developed ciprofloxacin loaded chitosan nanoparticles (cCNPs) and fucoidan (Fu) coated cCNPs (Fu-cCNPs). Characterizations of these nanoparticles were carried out using Dynamic Light Scattering‎, Transmission electron microscopy and Fourier transform infrared spectroscopy. The prepared cCNPs and Fu-cCNPs have the size range of 124±7nm and 320±18nm, respectively...
September 5, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28918561/marine-polysaccharides-therapeutic-efficacy-and-biomedical-applications
#20
REVIEW
Young-Eun Lee, Hyeongmin Kim, Changwon Seo, Taejun Park, Kyung Bin Lee, Seung-Yup Yoo, Seong-Chul Hong, Jeong Tae Kim, Jaehwi Lee
The ocean contains numerous marine organisms, including algae, animals, and plants, from which diverse marine polysaccharides with useful physicochemical and biological properties can be extracted. In particular, fucoidan, carrageenan, alginate, and chitosan have been extensively investigated in pharmaceutical and biomedical fields owing to their desirable characteristics, such as biocompatibility, biodegradability, and bioactivity. Various therapeutic efficacies of marine polysaccharides have been elucidated, including the inhibition of cancer, inflammation, and viral infection...
September 2017: Archives of Pharmacal Research
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