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Fucoidan

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https://www.readbyqxmd.com/read/28733632/3d-anatomical-and-perfusion-mri-for-longitudinal-evaluation-of-biomaterials-for-bone-regeneration-of-femoral-bone-defect-in-rats
#1
Emeline J Ribot, Clement Tournier, Rachida Aid-Launais, Neha Koonjoo, Hugo Oliveira, Aurelien J Trotier, Sylvie Rey, Didier Wecker, Didier Letourneur, Joelle Amedee Vilamitjana, Sylvain Miraux
Magnetic Resonance Imaging (MRI) appears as a good surrogate to Computed Tomography (CT) scan as it does not involve radiation. In this context, a 3D anatomical and perfusion MR imaging protocol was developed to follow the evolution of bone regeneration and the neo-vascularization in femoral bone defects in rats. For this, three different biomaterials based on Pullulan-Dextran and containing either Fucoidan or HydroxyApatite or both were implanted. In vivo MRI, ex vivo micro-CT and histology were performed 1, 3 and 5 weeks after implantation...
July 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28732873/macromolecular-properties-and-hypolipidemic-effects-of-four-sulfated-polysaccharides-from-sea-cucumbers
#2
Shan Li, Junhui Li, Zijian Zhi, Chaoyang Wei, Wenjun Wang, Tian Ding, Xingqian Ye, Yaqin Hu, Robert J Linhardt, Shiguo Chen
The present study investigates the relationship between the high-order structure and hypolipidemic activity of four well-defined sulfated fucans from sea cucumber. The chain conformation, determined by a combination of AFM and SEC-MALLS-RI, indicate that fucosylated chondroitin sulfate (fCS) from Pearsonothuria graeffei (fCS-Pg) and Isostichopus badionotus (fCS-Ib), and fucoidan from P.graeffei (fuc-Pg) were assigned as a random coil conformation with polysaccharide chain outstretched, while I. badionotus (fuc-Ib) was assigned as a spherical conformation and exhibited high viscosity...
October 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28714275/fucoidan-induced-osteogenic-differentiation-promotes-angiogenesis-by-inducing-vascular-endothelial-growth-factor-secretion-and-accelerates-bone-repair
#3
Beom-Su Kim, Sun-Sik Yang, Hyung-Keun You, Hong-In Shin, Jun Lee
Osteogenesis and angiogenesis, including cell-cell communication between blood vessel cells and bone cells, are essential for bone repair. Fucoidan is a chemical compound that has a variety of biological activities. It stimulates osteoblast differentiation in human mesenchymal stem cells (MSCs), which in turn induces angiogenesis. However, the mechanism by which this communication between osteoblasts and endothelial cells is mediated remains unclear. Thus, the aim of this study was to clarify the relationship between fucoidan-induced osteoblastic differentiation in MSCs and angiogenesis in endothelial cells...
July 16, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28690171/a-fucoidan-fraction-purified-from-chnoospora-minima-a-potential-inhibitor-of-lps-induced-inflammatory-responses
#4
I P Shanura Fernando, K K Asanka Sanjeewa, Kalpa W Samarakoon, Won Woo Lee, Hyun-Soo Kim, Nalae Kang, P Ranasinghe, Hyi-Seung Lee, You-Jin Jeon
Fucoidans are an interesting group of bioactive sulfated polysaccharides abundant in brown seaweeds. The current study highlights the enrichment and extraction of fucoidan from Chnoospora minima by means of enzyme-assistant extraction using Celluclast and evaluation of its anti-inflammatory potential through in vitro and in vivo studies. The purified C. minima fucoidan (F2,4) inhibited the nitrous oxide (NO) production (IC50=27.82±0.88μg/ml) and expression of PGE2 through the subsequent downregulation of iNOS and COX-2 expression in lipopolysaccharide (LPS) stimulated RAW 264...
July 6, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28684767/facile-control-over-the-supramolecular-ordering-of-self-assembled-peptide-scaffolds-by-simultaneous-assembly-with-a-polysacharride
#5
Rui Li, Mitchell Boyd-Moss, Benjamin Long, Anne Martel, Andrew Parnell, Andrew J C Dennison, Colin J Barrow, David R Nisbet, Richard J Williams
Enabling control over macromolecular ordering and the spatial distribution of structures formed via the mechanisms of molecular self-assembly is a challenge that could yield a range of new functional materials. In particular, using the self-assembly of minimalist peptides, to drive the incorporation of large complex molecules will allow a functionalization strategy for the next generation of biomaterial engineering. Here, for the first time, we show that co-assembly with increasing concentrations of a highly charged polysaccharide, fucoidan, the microscale ordering of Fmoc-FRGDF peptide fibrils and subsequent mechanical properties of the resultant hydrogel can be easily and effectively manipulated without disruption to the nanofibrillar structure of the assembly...
July 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28683274/sulfated-polysaccharides-of-the-vietnamese-brown-alga-sargassum-aquifolium-fucales-sargassaceae
#6
Maria I Bilan, Nadezhda E Ustyuzhanina, Alexander S Shashkov, Thi Thu Thuy Thanh, Minh Ly Bui, Thi Thanh Van Tran, Van Nguyen Bui, Anatolii I Usov
A fucoidan preparation named FSA was isolated from the brown alga Sargassum aquifolium collected from the coastal waters of Vietnam. l-Fucose, d-galactose, d-mannose, d-glucuronic acid, d-xylose, and sulfate were found to be the main constituents of FSA. The preparation was fractionated by anion-exchange chromatography on DEAE-Sephacel eluted stepwise with 0.5, 1.0, 1.5, and 2.0 M NaCl to give four fractions differing in monosaccharide composition and degree of sulfation. Their NMR spectra were too complex to be completely interpreted...
June 27, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/28673715/muscle-pain-induced-by-static-contraction-in-rats-is-modulated-by-peripheral-inflammatory-mechanisms
#7
Diogo Francisco da Silva Dos Santos, Bruna de Melo Aquino, Carolina Ocanha Jorge, Graciana de Azambuja, Jalile Garcia Schiavuzzo, Suzy Krimon, Juliana Dos Santos Neves, Carlos Amilcar Parada, Maria Claudia Gonçalves Oliveira-Fusaro
Muscle pain is an important health issue and frequently related to static force exertion. The aim of this study is to evaluate whether peripheral inflammatory mechanisms are involved with static contraction-induced muscle pain in rats. To this end, we developed a model of muscle pain induced by static contraction performed by applying electrical pulses through electrodes inserted into muscle. We also evaluated the involvement of neutrophil migration, bradykinin, sympathetic amines and prostanoids. A single session of sustained static contraction of gastrocnemius muscle induced acute mechanical muscle hyperalgesia without affecting locomotor activity and with no evidence of structural damage in muscle tissue...
June 30, 2017: Neuroscience
https://www.readbyqxmd.com/read/28664960/the-influence-of-polyanion-molecular-weight-on-polyelectrolyte-multilayers-at-surfaces-protein-adsorption-and-protein-polysaccharide-complexation-stripping-on-natural-polysaccharide-films-on-solid-supports
#8
Natalie L Benbow, Jessie L Webber, Sam Karpiniec, Marta Krasowska, James K Ferri, David A Beattie
Two different fucoidan polymers (unfractionated Fucus vesiculosus fucoidan, and fractionated low molecular weight Fucus vesiculosus fucoidan) have been used to create substrates for protein adsorption studies. Polyelectrolyte multilayers were formed using the fucoidans (polyanions) with chitosan as the corresponding polycation. Multilayer formation was studied using zeta potential measurements, quartz crystal microbalance with dissipation monitoring (QCM-D) and attenuated total reflectance (ATR) FTIR spectroscopy...
June 30, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28648622/a-novel-antimicrobial-therapy-for-the-control-of-aeromonas-hydrophila-infection-in-aquaculture-using-marine-polysaccharide-coated-gold-nanoparticle
#9
Sekar Vijayakumar, Baskaralingam Vaseeharan, Balasubramanian Malaikozhundan, Narayanan Gobi, Samuthirapandian Ravichandran, Sellamuthu Karthi, Balasubramaniem Ashokkumar, Natesan Sivakumar
In the present study, we prepared fucoidan coated Au-NPs (Fu-AuNPs), and examined its antimicrobial activity against Aeromonas hydrophila. The green synthesized Fu-AuNPs were bio-physically characterized by Ultraviolet-visible (UV-Vis) spectroscopy, X-ray Diffraction (XRD), Fourier Transform Infrared spectroscopy (FTIR), Higher Transmission Electron Microscopy (HR-TEM), Zeta potential analysis and Energy Dispersive X-ray spectroscopy (EDX). Fu-AuNPs were crystalline in nature, spherical to triangular in shape, with particle size ranging within 10-100 nm...
June 23, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28643951/magnetic-graphene-oxide-modified-by-imidazole-based-ionic-liquids-for-the-magnetic-based-solid-phase-extraction-of-polysaccharides-from-brown-alga
#10
Xiaoqin Wang, Guizhen Li, Kyung Ho Row
Magnetic graphene oxide was modified by four imidazole-based ionic liquids to synthesize materials for the extraction of polysaccharides by magnetic solid-phase extraction. Fucoidan and laminarin were chosen as the representative polysaccharides owing to their excellent pharmaceutical value and availability. FTIR spectroscopy, field-emission scanning electron microscopy and thermogravimetric analysis were applied to characterize the synthesized materials. Single-factor experiments showed that the extraction efficiency of polysaccharides was affected by the amount of ionic liquids for modification, solid-liquid ratio of brown alga and ethanol, the stirring time of brown alga and ionic liquid modified magnetic graphene oxide materials, and amount of 1-(3-aminopropyl)imidazole chloride modified magnetic graphene oxide materials added to the brown alga sample solution...
June 23, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28640204/fucoidan-does-not-exert-anti-tumorigenic-effects-on-uveal-melanoma-cell-lines
#11
Michaela Dithmer, Anna-Maria Kirsch, Elisabeth Richert, Sabine Fuchs, Fanlu Wang, Harald Schmidt, Sarah E Coupland, Johann Roider, Alexa Klettner
BACKGROUND: The polysaccharide fucoidan is widely investigated as an anti-cancer agent. Here, we tested the effect of fucoidan on uveal melanoma cell lines. METHODS: The effect of 100 µM fucoidan was investigated on five cell lines (92.1, Mel270 OMM1, OMM2.3, OMM2.5) and of 1 µg/mL-1 mg/mL fucoidan in two cell lines (OMM1, OMM2.3). Cell proliferation and viability were investigated with a WST-1 assay, migration in a wound healing (scratch) assay. Vascular Endothelial Growth Factor (VEGF) was measured in ELISA...
June 22, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28638878/effect-of-fucoidan-on-b16-murine-melanoma-cell-melanin-formation-and-apoptosis
#12
Zhi-Jiang Wang, Wei Xu, Jian-Wen Liang, Cai-Sheng Wang, Yani Kang
BACKGROUND: Fucoidan is a complex sulfated polysaccharide extracted from brown seaweed and has a wide variety of biological activities. It not only inhibits cancer cell growth but also inhibits tyrosinase in vitro. Therefore, it is of interest to investigate the effect of fucoidan on B16 murine melanoma cells as the findings may provide new insights into the underlying mechanism regarding the inhibition of melanin formation by fucoidan. In the present study, we aimed to investigate the anti-melanogenic effect of fucoidan and its inhibitory effect on B16 cells...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28635654/the-identification-of-a-sirt6-activator-from-brown-algae-fucus-distichus
#13
Minna K Rahnasto-Rilla, Padraig McLoughlin, Tomasz Kulikowicz, Maire Doyle, Vilhelm A Bohr, Maija Lahtela-Kakkonen, Luigi Ferrucci, Maria Hayes, Ruin Moaddel
Brown seaweeds contain many bioactive compounds, including polyphenols, polysaccharides, fucosterol, and fucoxantin. These compounds have several biological activities, including anti-inflammatory, hepatoprotective, anti-tumor, anti-hypertensive, and anti-diabetic activity, although in most cases their mechanisms of action are not understood. In this study, extracts generated from five brown algae (Fucus dichitus, Fucus vesiculosus (Linnaeus), Cytoseira tamariscofolia, Cytoseira nodacaulis, Alaria esculenta) were tested for their ability to activate SIRT6 resulting in H3K9 deacetylation...
June 21, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28632184/crude-fucoidan-extracts-impair-angiogenesis-in-models-relevant-for-bone-regeneration-and-osteosarcoma-via-reduction-of-vegf-and-sdf-1
#14
Fanlu Wang, Harald Schmidt, Dijana Pavleska, Thees Wermann, Andreas Seekamp, Sabine Fuchs
The marine origin polysaccharide fucoidan combines multiple biological activities. As demonstrated by various studies in vitro and in vivo, fucoidans show anti-viral, anti-tumor, anti-oxidant, anti-inflammatory and anti-coagulant properties, although the detailed molecular action remains to be elucidated. The aim of the present study is to assess the impact of crude fucoidan extracts, on the formation of vascular structures in co-culture models relevant for bone vascularization during bone repair and for vascularization processes in osteosarcoma...
June 20, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28629153/compositional-characteristics-and-in-vitro-evaluations-of-antioxidant-and-neuroprotective-properties-of-crude-extracts-of-fucoidan-prepared-from-compressional-puffing-pretreated-sargassum-crassifolium
#15
Wen-Ning Yang, Po-Wei Chen, Chun-Yung Huang
Fucoidan, a fucose-containing sulfated polysaccharide with diverse biological functions, is mainly recovered from brown algae. In this study, we utilized a compressional-puffing process (CPP) to pretreat Sargassum crassifolium (SC) and extracted fucoidans from SC by warm water. Three fucoidan extracts (SC1: puffing at 0 kg/cm²; SC2: puffing at 1.7 kg/cm²; and SC3: puffing at 6.3 kg/cm²) were obtained, and their composition, and antioxidant and neuroprotective activities were examined. The results suggest that CPP decreased the bulk density of algal samples, expanded the algal cellular structures, and eliminated the unpleasant algal odor...
June 18, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28627391/low-molecular-weight-fucoidan-and-its-fractions-inhibit-renal-epithelial-mesenchymal-transition-induced-by-tgf-%C3%AE-1-or-fgf-2
#16
Xinpeng Li, Xiaohong Li, Quanbin Zhang, Tingting Zhao
We investigated the renal protective effects of low molecular weight fucoidan (LMWF) and its two fractions (F0.5 and F1.0), which were extracted from Laminaria japonica, on the epithelial-mesenchymal transition (EMT) induced by transforming growth factor beta 1 (TGF-β1) and fibroblast growth factor 2 (FGF-2) in HK-2 human renal proximal tubular cells. Cell morphology and EMT markers (fibronectin and alpha-smooth muscle actin) demonstrated that cells treated with TGF-β1 or FGF-2 developed EMT to a significant extent...
June 13, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28627320/an-exploratory-study-on-the-anti-inflammatory-effects-of-fucoidan-in-relation-to-quality-of-life-in-advanced-cancer-patients
#17
Hidenori Takahashi, Mitsuhiko Kawaguchi, Kunihiro Kitamura, Seiji Narumiya, Munenori Kawamura, Isamu Tengan, Shinji Nishimoto, Yasuo Hanamure, Yasuo Majima, Shuichi Tsubura, Kiichiro Teruya, Sanetaka Shirahata
BACKGROUND: Conventional anticancer therapies still cause difficulties with selective eradication and accompanying side effects that reduce patients' quality of life (QOL). Fucoidan is extracted from seaweeds and has already exhibited broad bioactivities, including anticancer and anti-inflammatory properties, in basic studies. It is expected to enhance therapeutic efficacy and minimize side effects in cancer patients; however, despite its potential benefits, there are very few clinical trials using fucoidans...
February 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/28606538/antibacterial-activity-and-mechanisms-of-depolymerized-fucoidans-isolated-from-laminaria-japonica
#18
Ming Liu, Yixiang Liu, Min-Jie Cao, Guang-Ming Liu, Qingchou Chen, Lechang Sun, Haixiu Chen
Fucoidans, sulfated polysaccharides in brown algae, were depolymerized though high-pressure hydrolysis, and their antibacterial activity, structural properties, and antibacterial mechanisms were investigated in this work. The fucoidans from Laminaria japonica show no antibacterial activity before depolymerization; however, their depolymerized products can effectively (p<0.05) inhibit the proliferation of Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). The structure-activity study demonstrated that lower molecular weight and stronger polyanionic property can promote the antibacterial activity...
September 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28586308/an-extract-from-the-atlantic-brown-algae-sacchorhiza-polyschides-counteracts-diet-induced-obesity-in-mice-via-a-gut-related-multi-factorial-mechanisms
#19
Patricia Huebbe, Sibylle Nikolai, Anke Schloesser, Diran Herebian, Graeme Campbell, Claus-Christian Glüer, Annette Zeyner, Tobias Demetrowitsch, Karin Schwarz, Cornelia C Metges, Thomas Roeder, Gerhard Schultheiss, Ignacio R Ipharraguerre, Gerald Rimbach
In this study we addressed the questions whether an Atlantic brown algae extract (BAE) affects diet induced obesity in mice and which would be the primary targets and underlying key mechanisms.Male C57 BL/6 mice were fed a hypercaloric diet, referred to as high fat diet (HFD), supplemented with a freeze-dried aqueous BAE from Sacchorizia polyschides (5 %) for 8 months. Compared to the control group, dietary BAE supplementation significantly attenuated increase in body weight and fat mass. We observed apparent metabolic improvement including normalization of blood glucose, reduced plasma leptin, reduced fecal bile salt hydrolase activity with lower microbial production of toxic bile acid metabolites in the gut and increased systemic bile acid circulation in BAE-fed mice counteracting adverse effects of long term HFD feeding...
May 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28555064/induction-of-p53-independent-apoptosis-and-g1-cell-cycle-arrest-by-fucoidan-in-hct116-human-colorectal-carcinoma-cells
#20
Hye Young Park, Shin-Hyung Park, Jin-Woo Jeong, Dahye Yoon, Min Ho Han, Dae-Sung Lee, Grace Choi, Mi-Jin Yim, Jeong Min Lee, Do-Hyung Kim, Gi-Young Kim, Il-Whan Choi, Suhkmann Kim, Heui-Soo Kim, Hee-Jae Cha, Yung Hyun Choi
It is well known that fucoidan, a natural sulfated polysaccharide present in various brown algae, mediates anticancer effects through the induction of cell cycle arrest and apoptosis. Nevertheless, the role of tumor suppressor p53 in the mechanism action of fucoidan remains unclear. Here, we investigated the anticancer effect of fucoidan on two p53 isogenic HCT116 (p53+/+ and p53-/-) cell lines. Our results showed that inhibition of cell viability, induction of apoptosis and DNA damage by treatment with fucoidan were similar in two cell lines...
May 30, 2017: Marine Drugs
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