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https://www.readbyqxmd.com/read/29678783/safety-and-efficacy-of-stereotactic-radioablation-targeting-pulmonary-vein-tissues-in-an-experimental-model
#1
Paul C Zei, Doug Wong, Edward Gardner, Thomas Fogarty, Patrick Maguire
BACKGROUND: Stereotactic radioablation (SR), a commonly used therapy to treat malignancies, has been utilized to treat refractory ventricular tachycardia, but the feasibility of treating atrial fibrillation (AF) with SR is unknown. OBJECTIVE: We evaluated the safety and efficacy of SR targeting pulmonary vein (PV) antral tissues as potential therapy for AF. METHODS: Seventeen adult canines and two adult swine underwent surgical fiducial marker placement, 3D anatomic rendering CT angiogram of the left atrium (LA), and creation of a treatment plan targeting the right superior pulmonary veins (RSPVs)...
April 17, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29678334/evaluation-of-canine-sperm-and-management-of-semen-disorders
#2
REVIEW
Kara A Kolster
Semen evaluation of the male dog is a critical step in any canine infertility work-up. Assessment of total sperm count, sperm viability, and sperm morphology are the mainstay of breeding soundness evaluation. Adjunct tests, such as ultrasonography and serum hormone levels, can aid in diagnosis. Pharmacologic treatments, dietary supplements, and management practices may help improve breeding success in subfertile dogs. This article discusses a clinically practical approach to assessing sperm abnormalities and fertility in male dogs...
April 17, 2018: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/29677186/morphophysiological-changes-in-the-splenic-extracellular-matrix-of-leishmania-infantum-naturally-infected-dogs-is-associated-with-alterations-in-lymphoid-niches-and-the-cd4-t-cell-frequency-in-spleens
#3
Aurea Virginia Andrade da Silva, Fabiano Borges Figueiredo, Rodrigo Caldas Menezes, Arthur Augusto Mendes-Junior, Luisa Helena Monteiro de Miranda, Elisa Cupolillo, Renato Porrozzi, Fernanda Nazaré Morgado
The spleen is one of the main affected organs in canine visceral leishmaniasis (CVL). Disorganization of the splenic white pulp (SWP) has been associated with immunosuppression and disease progression. This study aims to assess structural and cellular changes in the splenic extracellular matrix of dogs with CVL, correlating these changes with the parasite load and clinical signs. Splenic fragments were collected from 41 naturally infected animals for parasite load quantification by quantitative PCR, histopathological analysis and immunohistochemistry for CD3+, CD4+, and CD8+ T cells; CD21+ B cells; Ki-67+, IFN-γ+, and IL-10+ cells; and the MMP-9 and ADAM-10 enzymes...
April 20, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29676258/-multiple-uses-of-skeletal-anchorages-taking-advantage-of-mini-screws-to-improve-aesthetics-with-active-and-passive-appliances
#4
Stéphane Renger, Mélanie Gremeret, Sarah Gebeile-Chauty
INTRODUCTION: The main causes of failures in canine traction are anchorage defects, incorrect direction of force, uncontrolled forces. An adolescent female (10 years, 9 months) presents with two included canines on the maxillary arch, in a palatal position and her lateral incisors (12 and 22) are microdontic. Two mini-screws are inserted on the palate, in a mesial position to 16 and 26 to secure the traction of 13 and 23; in general, braces are bonded after this first step. After debonding, mini-screws remain to help stabilize the palatal plate during the retention period and to avoid unaesthetic metallic wires and hooks which sometimes cause occlusal interferences...
March 2018: L' Orthodontie Française
https://www.readbyqxmd.com/read/29675651/a-multiplex-pcr-method-for-the-simultaneous-detection-of-three-viruses-associated-with-canine-viral-enteric-infections
#5
Xiaoyu Deng, Jiali Zhang, Jiazi Su, Hao Liu, Yanlong Cong, Lei Zhang, Kemeng Zhang, Ning Shi, Rongguang Lu, Xijun Yan
The aim of this study was to establish a multiplex PCR (mPCR) method that can simultaneously detect canine parvovirus (CPV-2), canine coronavirus (CCoV) and canine adenovirus (CAV), thereby eliminating the need to detect these pathogens individually. Based on conserved regions in the genomes of these three viruses, the VP2 gene of CPV-2, the endoribonuclease nsp15 gene of CCoV, and the 52K gene of CAV were selected for primer design. The specificity of the mPCR results showed no amplification of canine distemper virus (CDV), canine parainfluenza virus (CPIV), or pseudorabies virus (PRV), indicating that the method had good specificity...
April 19, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29675448/intestinal-farnesoid-x-receptor-activation-by-pharmacologic-inhibition-of-the-organic-solute-transporter-%C3%AE-%C3%AE
#6
Sandra M W van de Wiel, D Rudi de Waart, Ronald P J Oude Elferink, Stan F J van de Graaf
Background & Aims: The organic solute transporter α-β (OSTα-OSTβ) mainly facilitates transport of bile acids across the basolateral membrane of ileal enterocytes. Therefore, inhibition of OSTα-OSTβ might have similar beneficial metabolic effects as intestine-specific agonists of the major nuclear receptor for bile acids, the farnesoid X receptor (FXR). However, no OSTα-OSTβ inhibitors have yet been identified. Methods: Here, we developed a screen to identify specific inhibitors of OSTα-OSTβ using a genetically encoded Förster Resonance Energy Transfer (FRET)-bile acid sensor that enables rapid visualization of bile acid efflux in living cells...
March 2018: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29675401/analysis-of-the-antigenic-and-prophylactic-properties-of-the-leishmania-translation-initiation-factors-eif2-and-eif2b-in-natural-and-experimental-leishmaniasis
#7
Esther Garde, Laura Ramírez, Laura Corvo, José C Solana, M Elena Martín, Víctor M González, Carlos Gómez-Nieto, Aldina Barral, Manoel Barral-Netto, José M Requena, Salvador Iborra, Manuel Soto
Different members of intracellular protein families are recognized by the immune system of the vertebrate host infected by parasites of the genus Leishmania . Here, we have analyzed the antigenic and immunogenic properties of the Leishmania eIF2 and eIF2B translation initiation factors. An in silico search in Leishmania infantum sequence databases allowed the identification of the genes encoding the α, β, and γ subunits and the α, β, and δ subunits of the putative Leishmania orthologs of the eukaryotic initiation factors F2 (LieIF2) or F2B (LieIF2B), respectively...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29674831/using-a-syringe-needle-to-cut-dentin-and-dislodge-and-remove-a-metallic-obstruction-from-the-root-canal
#8
A R Vivekananda Pai, Varun Arora
A metallic obstruction in the canal orifice of a maxillary right canine could not be bypassed during endodontic treatment. Aids such as ultrasonics and retrieval kits were not available for the removal of the obstruction. Therefore, a novel approach using a disposable syringe needle was employed. A 22-gauge needle was inserted into the orifice and turned in an arc with a gentle apical pressure and alternate rocking motion around the obstruction. This procedure was repeated few times to cut dentin and successfully dislodge and remove the obstruction using the sharp beveled tip of the needle...
March 2018: Journal of Conservative Dentistry: JCD
https://www.readbyqxmd.com/read/29674815/apical-dye-leakage-of-two-single-cone-root-canal-core-materials-hydrophilic-core-material-and-gutta-percha-sealed-by-different-types-of-endodontic-sealers-an-in-vitro-study
#9
Mohamed Abdel Aziz Mohamed El Sayed, Hussam Al Husseini
Aim of the Study: The aim of this study was to compare the apical sealing ability of two single-cone filling materials when sealed with different types of root canal sealers. Materials and Methods: Eighty extracted maxillary and mandibular canines were selected and their crowns were cut. The root canals were prepared using ProTaper Universal rotary system until size F4 and then divided into seven experimental groups ( n = 10 each) and two control groups ( n = 5 each)...
March 2018: Journal of Conservative Dentistry: JCD
https://www.readbyqxmd.com/read/29674676/comparative-high-resolution-transcriptome-sequencing-of-lymphoma-cell-lines-and-de-novo-lymphomas-reveals-cell-line-specific-pathway-dysregulation
#10
Leila Taher, Julia Beck, Wen Liu, Catrin Roolf, Jan T Soller, Barbara C Rütgen, Sabine E Hammer, Murali Chodisetti, Sina Sender, Katharina A Sterenczak, Georg Fuellen, Christian Junghanss, Bertram Brenig, Ingo Nolte, Ekkehard Schütz, Hugo Murua Escobar
In dogs as well as humans, lymphoma is one of the most common hematopoietic malignancies. Furthermore, due to its characteristics, canine lymphoma is recognized as a clinically relevant in vivo model to study the corresponding human disease. Immortalized cell lines are widely used as in vitro models to evaluate novel therapeutic agents and characterize their molecular mechanisms. However, it is known that long-term cultivation leads to clonal selection, genetic instability, and loss of the initial heterogenic character, limiting the usefulness of cell lines as preclinical models...
April 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29673177/the-hippo-yap-pathway-regulates-3d-organ-formation-and-homeostasis
#11
Erika Ishihara, Hiroshi Nishina
The vertebrate body shape is formed by the specific sizes and shapes of its resident tissues and organs, whose alignments are essential for proper functioning. To maintain tissue and organ shape, and thereby function, it is necessary to remove senescent, transformed, and/or damaged cells, which impair function and can lead to tumorigenesis. However, the molecular mechanisms underlying three-dimensional (3D) organ formation and homeostasis are not fully clear. Yes-associated protein (YAP) is a transcriptional co-activator that is involved in organ size control and tumorigenesis...
April 17, 2018: Cancers
https://www.readbyqxmd.com/read/29671048/expression-of-matrix-metalloproteinase-2-and-metalloproteinase-9-in-the-skin-of-dogs-with-visceral-leishmaniasis
#12
Ana Paula Prudente Jacintho, Guilherme D Melo, Gisele F Machado, Paulo Henrique Leal Bertolo, Pamela Rodrigues Reina Moreira, Claudia Momo, Thiago A Souza, Rosemeri de Oliveira Vasconcelos
The skin is the first organ to be infected by the parasite in canine visceral leishmaniasis. The enzyme matrix metalloproteinase (MMP) acts towards degradation of the extracellular matrix (ECM) and modulation of the inflammatory response against many kinds of injuries. The aims of this study were to evaluate the expression of MMP-2 and MMP-9 through immunohistochemistry and zymography on the skin (muzzle, ears, and abdomen) of dogs that were naturally infected by Leishmania spp. and to compare these results with immunodetection of the parasite and with alterations to the dermal ECM...
April 18, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29669547/cutaneous-lupus-erythematosus-in-dogs-a-comprehensive-review
#13
REVIEW
Thierry Olivry, Keith E Linder, Frane Banovic
Since the first description of discoid lupus erythematosus (LE) in two dogs in 1979, the spectrum of canine cutaneous lupus erythematosus (CLE) variants has expanded markedly.In this review, we first propose an adaptation of the Gilliam-Sontheimer classification of CLE for dogs. We then review the signalment, clinical signs, laboratory and histopathology and treatment outcome of the currently recognized variants of canine CLE, which are vesicular CLE, exfoliative CLE, mucocutaneous LE and facial or generalized discoid LE...
April 18, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29668949/molecular-evidence-for-a-novel-species-of-babesia-in-unfed-rhipicephalus-sanguineus-sensu-lato-acari-ixodidae
#14
Sezayi Ozubek, Munir Aktas
This study reports a novel species of Babesia in unfed Rhipicephalus sanguineus sensu lato and its phylogenetic relationship to other species. One-hundred and forty DNA samples extracted from tick pools comprising 5,403 unfed R. sanguineus s.l. ticks were screened for Babesia. Overall Babesia infection was detected in female, male, and nymph pools with an infection rate maximum likelihood estimate (MLE) of 1.98 (CI 0.65-4.74), 0.50 (CI 0.03-2.40), and 0.07 (CI 0.01-0.21), respectively. Three adult female tick pools (MLE 1...
April 16, 2018: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29667481/effects-of-ionising-radiation-on-telomere-length-and-telomerase-activity-in-cultured-human-lens-epithelium-cells
#15
Savneet Kaur Bains, Kim Chapman, Scott Bright, Anish Senan, Munira Kadhim, Predrag Slijepcevic
PURPOSE: To investigate the effects of ionising radiation on telomere length and telomerase activity in Human Lens Epithelial cells. There are studies suggesting evidence of telomere length in association with opacity of the lens, however, these studies have been conducted on Canine Lens cells. Our study was designed to understand further the effects of different doses of ionising radiation on telomere length and telomerase activity in cultured Human Lens Epithelium cells from three Donors...
April 18, 2018: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/29667468/growth-hormone-receptor-gene-is-related-to-root-length-and-tooth-length-in-human-teeth
#16
Yu Hikita, Tetsutaro Yamaguchi, Daisuke Tomita, Mohamed Adel, Takatoshi Nakawaki, Koshu Katayama, Koutaro Maki, Ryosuke Kimura
OBJECTIVES: To examine the relationship between tooth length and growth hormone receptor (GHR) gene variants in a healthy Japanese population. MATERIALS AND METHODS: The subjects consisted of 193 Japanese adults (69 men, 124 women), aged 13 to 56 years. Genomic DNA was extracted from saliva and genotyped GHR rs6184 and rs6180 variants using the Taqman genotyping. Computed tomography (CT) images were acquired using a dental cone-beam CT scanner and reconstructed using open-source OsiriX medical image processing software...
April 18, 2018: Angle Orthodontist
https://www.readbyqxmd.com/read/29667282/cardiac-gated-phase-contrast-magnetic-resonance-angiography-is-a-reliable-and-reproducible-technique-for-quantifying-blood-flow-in-canine-major-cranial-abdominal-vessels
#17
Francesca Del Chicca, Andrea Schwarz, Paula Grest, Florian Willmitzer, Matthias Dennler, Patrick R Kircher
Blood flow changes in cranial abdominal vessels are important contributing factors for canine hepatic disease. This prospective, experimental, pilot study aimed to evaluate cardiac-gated, phase contrast magnetic resonance angiography (PCMRA) as a method for characterizing blood flow in canine major cranial abdominal vessels. Eleven, healthy, adult beagle dogs were sampled. Cardiac-gated, phase contrast magnetic resonance angiography of the cranial abdomen was performed in each dog and blood flow was independently measured in each of the major cranial abdominal vessels by three observers, with two observers recording blood flow values once and one observer recording blood flow values three times...
April 17, 2018: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/29667183/effect-of-enterococcus-faecium-sf68-on-serum-cobalamin-and-folate-concentrations-in-healthy-dogs
#18
R Lucena, A B Olmedilla, B Blanco, M Novales, P J Ginel
OBJECTIVE: To study the effect of a 14-day administration of the probiotic Enterococcus faecium SF68 on serum concentrations of cobalamin and folate in healthy dogs. MATERIALS AND METHODS: Thirty-six healthy dogs were randomly allocated between probiotic and control groups. Enterococcus faecium SF68 was administered to the probiotic group for 14 days whereas the control group did not receive any product. A blood sample was taken from all dogs when starting the administration (day 1), when the administration ended (day 14) and 14 days later (day 28)...
April 17, 2018: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/29666221/details-of-canine-hydrotherapy-pools-and-treadmills-in-22-hydrotherapy-centres-in-the-united-kingdom
#19
Wanda McCormick, James Andrew Oxley, Naomi Spencer
No abstract text is available yet for this article.
April 17, 2018: Veterinary Record
https://www.readbyqxmd.com/read/29665827/effect-of-selected-gastrointestinal-parasites-and-viral-agents-on-fecal-s100a12-concentrations-in-puppies-as-a-potential-comparative-model
#20
Romy M Heilmann, Aurélien Grellet, Niels Grützner, Shannon M Cranford, Jan S Suchodolski, Sylvie Chastant-Maillard, Jörg M Steiner
BACKGROUND: Previous data suggest that fecal S100A12 has clinical utility as a biomarker of chronic gastrointestinal inflammation (idiopathic inflammatory bowel disease) in both people and dogs, but the effect of gastrointestinal pathogens on fecal S100A12 concentrations is largely unknown. The role of S100A12 in parasite and viral infections is also difficult to study in traditional animal models due to the lack of S100A12 expression in rodents. Thus, the aim of this study was to evaluate fecal S100A12 concentrations in a cohort of puppies with intestinal parasites (Cystoisospora spp...
April 17, 2018: Parasites & Vectors
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