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https://www.readbyqxmd.com/read/28090813/effects-of-fostriecin-on-%C3%AE-2-adrenoceptor-driven-responses-in-human-mast-cells
#1
Reza Bastan, Nahid Eskandari, Hamidrez J Ardakani, Peter T Peachell
As part of the intracellular processes leading to mast cell and basophil activation, phosphorylation of key substrates is likely to be important. These processes, mediated by phosphatases, are responsible for regulating phosphorylation. The aim of the present study was to determine effects fostriecin - a selective inhibitor of PP2A (protein phosphatase-2) - on β2-adrenoceptor-driven responses in human mast cells. Here, the effects of fostriecin (PP inhibitors) on the inhibition of histamine release from HLMC, on β-adrenoceptor-driven responses in mast cells and on desensitization were investigated...
January 16, 2017: Journal of Immunotoxicology
https://www.readbyqxmd.com/read/28064316/-changes-in-the-receptor-activity-of-%C3%AE-2-adrenoreceptors-of-human-t-lymphocytes-under-the-effect-of-%C3%AE-2-agonists
#2
O Y Agapova, Y S Skoblov, G A Tkachev, N A Mironova, S P Golitsyn, V P Masenko, I E Chazova, K A Zykov
Changes in the activity of β2-adrenergic receptors of human T-lymphocytes under the effect of salbutamol (a short-acting β2-agonist) have been evaluated with a new modified radioligand method utilizing [^(125)I]cyanopindolol and a specific ligand ICI 118551. In healthy volunteers, the receptor activity decreased after 30 min upon the inhalation of salbutamol and restored to the initial level after 2 h. At the same time, there were changes in the transcription level of the ADRB2 gene, which encodes the protein component of the β2-adrenoreceptor...
November 2016: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/28061018/bronchopulmonary-pharmacokinetics-of-r-salbutamol-and-s-salbutamol-enantiomers-in-pulmonary-epithelial-lining-fluid-and-lung-tissue-of-horses
#3
Glenn A Jacobson, Sharanne Raidal, Kate Robson, Christian K Narkowicz, David S Nichols, E Haydn Walters
AIMS: Salbutamol is usually administered as a racemic mixture but little is known about the enantioselectivity of salbutamol pharmacokinetics in the lung. This study was designed to investigate enantiomer concentrations in lung tissue after inhaled dosing. METHODS: Horses (n = 12) received racemic (rac-) salbutamol 1000 microgram via inhalation. Enantioselective UPLC-MS/MS was used to determine salbutamol concentrations in pulmonary epithelial lining fluid (PELF) sampled 2, 5, 10 and 15 min after administration, in central lung (endoscopic bronchial biopsy) and peripheral lung (percutaneous pulmonary biopsy) tissues (at 20 and 25 minutes respectively), and in plasma samples...
January 6, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28028708/aquatic-photolysis-of-%C3%AE-2-agonist-salbutamol-kinetics-and-mechanism-studies
#4
Lei Zhou, Qi Wang, Ya Zhang, Yuefei Ji, Xi Yang
Salbutamol (SAL) has been widely used as medicine both in treating asthma and in animal primary production; an increasing number of reports have detected SAL in natural waters. The photolysis kinetic and pathway of SAL in aquatic system were studied, as well as the effect of several natural water constituents, such as nitrate, dissolved oxygen (DO) and ferric ions. According to our research, the direct photolysis of SAL followed pseudo-first-order reaction kinetics. Alkaline condition could promote the degradation of SAL; the increase of solution pH would simultaneously increase the fraction of the deprotonated forms of SAL (including the deprotonated and zwitterionic species), which were easier to be excited, and result in the bathochromic shift of the UV-Vis spectrum and, finally, accelerate the degradation rate of SAL...
December 27, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28027938/superimposed-pressure-oscillations-an-alternative-to-treat-airway-hyperresponsiveness-in-an-acute-sensitized-airways-mouse-model
#5
M J Jo-Avila, A M Al-Jumaily
The main driving mechanism during an asthma attack is the hyper-constrictions of airway smooth muscle (ASM), which reduces the airway lumen and makes normal breathing difficult. In spite of some noticeable side effects, bronchodilator drugs such as salbutamol are used to alleviate these symptoms by inducing temporary relaxation of the contracted ASM. In vitro studies have shown that mechanical oscillation can induce relaxation in isolated contracted ASM obtained from healthy subjects but not from asthmatics...
December 24, 2016: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/27999602/anaphylaxis-to-supplemental-oral-lactase-enzyme
#6
M R Voisin, R Borici-Mazi
BACKGROUND: Anaphylactic reactions involving IgE mediated hypersensitivity have been frequently reported for a number of uncommon foods. However, cases of anaphylaxis to over the counter vitamins and oral supplements have been rarely published. Lactose intolerance affects approximately 20% of Canadians and roughly 70% of the world's population of any age. Lactose intolerance develops primarily due to the absence of the enzyme lactase and treatment involves avoidance of lactose-containing foods or ingestion of commercially available lactase enzyme preparations prior to their consumption...
2016: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/27960245/bronchodilators-for-the-prevention-and-treatment-of-chronic-lung-disease-in-preterm-infants
#7
REVIEW
Geraldine Ng, Orlando da Silva, Arne Ohlsson
BACKGROUND: Chronic lung disease (CLD) occurs frequently in preterm infants. Bronchodilators have the potential effect of dilating small airways with muscle hypertrophy. Increased compliance and tidal volume and decreased pulmonary resistance have been documented with the use of bronchodilators in infants with CLD. Therefore, bronchodilators might have a role in the prevention and treatment of CLD. OBJECTIVES: To determine the effect of bronchodilators given as prophylaxis or as treatment for CLD on mortality and other complications of preterm birth in infants at risk for or identified as having CLD...
14, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27942208/three-minute-constant-rate-step-test-for-detecting-exertional-dyspnea-relief-after-bronchodilation-in-copd
#8
Benoit Borel, Courtney A Wilkinson-Maitland, Alan Hamilton, Jean Bourbeau, Hélène Perrault, Dennis Jensen, François Maltais
BACKGROUND: The aim of this study was to evaluate the responsiveness of the 3-minute constant rate step test (3-MST) to detect the relief of exertional dyspnea (respiratory discomfort) after acute bronchodilation in COPD patients. PATIENTS AND METHODS: A total of 40 patients with moderate-to-severe COPD (mean forced expiratory volume in 1 second: 45.7 (±14.7), % predicted) performed four 3-MSTs at randomly assigned stepping rates of 14, 16, 20 and 24 steps/min after inhalation of nebulized ipratropium bromide (500 µg)/salbutamol (2...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27942102/quality-of-acute-asthma-care-in-two-tertiary-hospitals-in-a-state-in-south-western-nigeria-a-report-of-clinical-audit
#9
Olufemi Olumuyiwa Desalu, Adekunle Olatayo Adeoti, Olarinde Jeffrey Ogunmola, Joseph Olusesan Fadare, Tolutope Fasanmi Kolawole
BACKGROUND: To audit the quality of acute asthma care in two tertiary hospitals in a state in the southwestern region of Nigeria and to compare the clinical practice against the recommendations of the Global Initiative for Asthma (GINA) guideline. PATIENTS AND METHODS: We carried out a retrospective analysis of 101 patients who presented with acute exacerbation of asthma to the hospital between November 2010 and October 2015. RESULTS: Majority of the cases were females (66...
November 2016: Nigerian Medical Journal: Journal of the Nigeria Medical Association
https://www.readbyqxmd.com/read/27939234/evaluation-of-granulated-lactose-as-a-carrier-for-dry-powder-inhaler-formulations-2-effect-of-drugs-and-drug-loading
#10
Ping Du, Ju Du, Hugh D C Smyth
Previously, granulated lactose carriers were shown to improve uniformity and aerosolization of a low-dose model drug. In the present study, the blending uniformity and aerosol dispersion performance were assessed for 2 model drugs salbutamol sulfate (SS) and rifampicin (RIF), blended at high loadings (10% or 30% drug) with granulated lactose carriers. The model drug powders differed in particle size distribution, morphology, density, and surface energies. Content uniformity of RIF blends was better than that of SS...
January 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27932874/bronchodilator-response-of-advanced-lung-function-parameters-depending-on-copd-severity
#11
Linnea Jarenbäck, Göran Eriksson, Stefan Peterson, Jaro Ankerst, Leif Bjermer, Ellen Tufvesson
BACKGROUND: COPD is defined as partly irreversible airflow obstruction. The response pattern of bronchodilators has not been followed in advanced lung function parameters. PURPOSE: The aim of this study was to investigate bronchodilator response pattern in advanced lung function parameters in a continuous fashion along forced expiratory volume in 1 second (FEV1) percent predicted (%p) in COPD patients and controls. PATIENTS AND METHODS: Eighty-one smokers/ex-smokers (41 controls and 40 COPD) performed spirometry, body plethysmography, impulse oscillometry and single-breath helium dilution carbon monoxide diffusion at baseline, after salbutamol inhalation and then after an additional inhalation of ipratropium...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27915194/quantitative-determination-of-salbutamol-sulfate-impurities-using-achiral-supercritical-fluid-chromatography
#12
Amandine Dispas, Vincent Desfontaine, Bertyl Andri, Pierre Lebrun, Dorina Kotoni, Adrian Clarke, Davy Guillarme, Philippe Hubert
In the last years, supercritical fluid chromatography has largely been acknowledged as a singular and performing technique in the field of separation sciences. Recent studies highlighted the interest of SFC for the quality control of pharmaceuticals, especially in the case of the determination of the active pharmaceutical ingredient (API). Nevertheless, quality control requires also the determination of impurities. The objectives of the present work were to (i) demonstrate the interest of SFC as a reference technique for the determination of impurities in salbutamol sulfate API and (ii) to propose an alternative to a reference HPLC method from the European Pharmacopeia (EP) involving ion-pairing reagent...
February 5, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27898948/%C3%AE-and-%C3%AE-adrenergic-receptors-stimulation-relaxes-porcine-myometrium-in-the-peri-implantation-period
#13
W Markiewicz, J J Jaroszewski
These studies were to demonstrate whether the β-receptor is involved in regulating the contractility of the swine myometrium in the peri-implantation period and to compare a relaxing activity of selective β- and β-adrenergic agonists (salbutamol and BRL 37344, respectively). Myometrial strips were collected form the gilts ( = 8) on d 12 to 14 of pregnancy. Changes in the contractility of myometrial strips were assessed further to the administration of increasing concentrations of the agonists (10 to 10 ) with and without β-adrenergic receptor antagonists: butoxamine, propranolol, and bupranolol at 10 ...
November 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27898378/ag-n-doped-reduced-graphene-oxide-incorporated-with-molecularly-imprinted-polymer-an-advanced-electrochemical-sensing-platform-for-salbutamol-determination
#14
Junhua Li, Zhifeng Xu, Mengqin Liu, Peihong Deng, Siping Tang, Jianbo Jiang, Haibo Feng, Dong Qian, Lingzhi He
In this work, the metallic silver and non-metallic nitrogen co-doped reduced graphene oxide (Ag-N-RGO) was first synthesized by a simple and cost-effective strategy, and then a molecularly imprinted polymer (MIP) was formed in situ at the surface of the prepared composite via electropolymerization of o-phenylenediamine in the presence of salbutamol as the template molecule. The electrochemical characterizations demonstrate that the bifunctional graphene-based composite shows improved catalytic performance than that of pristine graphene doped with one-component or none...
April 15, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27892438/comparison-of-initial-response-of-nebulized-salbutamol-and-adrenaline-in-infants-and-young-children-admitted-with-acute-bronchiolitis
#15
S Adhikari, P Thapa, K S Rao, G Bk
Background Acute bronchiolitis is common cause of hospitalization in infants and young children. There are widespread variations in the diagnosis and management. Despite the use of bronchodilators for decades, there is lack of consensus for the benefit of one above another. Objective To compare initial response of nebulized adrenaline and salbutamol. Method Children aged two months to two years admitted with acute bronchiolitis in the department of Paediatrics of Manipal teaching hospital, Pokhara, Nepal, from 1st March 2014 to 28th February 2015 were enrolled...
January 2016: Kathmandu University Medical Journal (KUMJ)
https://www.readbyqxmd.com/read/27888987/free-asthma-medications-reduces-hospital-admissions-in-brazil-free%C3%A2-asthma-drugs-reduces-hospitalizations-in-brazil
#16
Talitha Comaru, Paulo Márcio Pitrez, Frederico Orlando Friedrich, Victória D Silveira, Leonardo A Pinto
BACKGROUND: Since June 2011, the Brazilian health system started providing asthma medications (beclomethasone and salbutamol), totally free of charge to patients with asthma. The aim of this study was to evaluate the impact of the provision of free asthma medications on hospital admissions for asthma in Brazil, using a national hospitalization database (DATASUS), comparing the incidence of hospital admissions before and after the free supply of these drugs. METHODS: Admissions of patients with 1-49 years of age by the Brazilian public health system with the diagnosis of asthma were compared pre (2008-2010) and post (2012-2014) provision of free medicines (beclomethasone and salbutamol)...
December 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27888478/examining-the-quality-of-medicines-at-kenyan-healthcare-facilities-a-validation-of-an-alternative-post-market-surveillance-model-that-uses-standardized-patients
#17
Francis Wafula, Amy Dolinger, Benjamin Daniels, Njeri Mwaura, Guadalupe Bedoya, Khama Rogo, Ana Goicoechea, Jishnu Das, Bernard Olayo
BACKGROUND: Promoting access to medicines requires concurrent efforts to strengthen quality assurance for sustained impact. Although problems of substandard and falsified medicines have been documented in low- and middle-income countries, reliable information on quality is rarely available. OBJECTIVE: The aim of this study was to validate an alternative post-market surveillance model to complement existing models. METHODS: The study used standardized patients or mystery clients (people recruited from the local community and trained to pose as real patients) to collect medicine samples after presenting a pre-specified condition...
November 25, 2016: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/27866986/modelling-of-in-vitro-and-in-vivo-performance-of-aerosol-emitted-from-different-vibrating-mesh-nebulisers-in-non-invasive-ventilation-circuit
#18
Hoda Rabea, Ahmed M A Ali, Randa Salah Eldin, Maha M Abdelrahman, Amira S A Said, Mohamed E Abdelrahim
Substituting nebulisers by another in non-invasive ventilation circuit (NIV) involves many process variables which must be adjusted to ensure patient optimum therapy. However, there is a doubt when nebulisers use the same technology. Data mining technology based on artificial neural networks and genetic algorithms were used here to model in-vitro inhalation process and predict bioavailability from inhaled doses delivered by three different vibrating mesh nebulisers (VMNs) in NIV. Modelling of data indicated that in-vitro performance of VMNs was dependent mainly on fine particle fraction, mass median aerodynamic diameter (MMAD), total emitted dose (TED) and to lesser extent on nebuliser type...
January 15, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27859454/rapid-analysis-of-interaction-between-six-drugs-and-%C3%AE-2-adrenergic-receptor-by-injection-amount-dependent-method
#19
Kaizhu Zeng, Jing Wang, Zhenyu Sun, Qian Li, Sha Liao, Xinfeng Zhao, Xiaohui Zheng
Drug-protein interaction analysis has become a considerable topic in life science which includes clarifying protein functions, explaining drug action mechanisms and uncovering novel drug candidates. This work was to determine the association constants (KA ) of six drugs to β2 -adrenergic receptor by injection amount dependent method using stationary phase containing the immobilized receptor. The association constants (KA ) were calculated to be (25.85 ± 0.035) × 10(4)  M(-1) for clorprenaline, (42...
November 15, 2016: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/27836009/how-can-we-optimise-inhaled-beta2-agonist-dose-as-reliever-medicine-for-wheezy-pre-school-children-study-protocol-for-a-randomised-controlled-trial
#20
Somnath Mukhopadhyay, Paul Seddon, Gemma Earl, Emma Wileman, Liz Symes, Cathy Olden, Corinne Alberti, Stephen Bremner, Alison Lansley, Colin N A Palmer, Nicole Beydon
BACKGROUND: Asthma is a common problem in children and, if inadequately controlled, may seriously diminish their quality of life. Inhaled short-acting beta2 agonists such as salbutamol are usually prescribed as 'reliever' medication to help control day-to-day symptoms such as wheeze. As with many medications currently prescribed for younger children (defined as those aged 2 years 6 months to 6 years 11 months), there has been no pre-licensing age-specific pharmacological testing; consequently, the doses currently prescribed (200-1000 μg) may be ineffective or likely to induce unnecessary side effects...
November 11, 2016: Trials
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