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https://www.readbyqxmd.com/read/28732286/development-of-liquid-chromatographic-methods-for-enantioseparation-and-sensitive-detection-of-%C3%AE-adrenolytics-%C3%AE-2-agonists-in-human-plasma-using-a-single-enantiomer-reagent
#1
Poonam Malik, Ravi Bhushan
Enantioseparation of four commonly used β-adrenolytics (bisoprolol, salbutamol, and carvedilol, marketed as racemic mixtures) has been achieved by both TLC and RPHPLC via an indirect approach. A new chiral reagent, (S)-naproxen benzotriazole ester, was synthesized and it was characterized by UV, IR, (1)HNMR, elemental analysis and polarimetry. It was used to synthesize diastereomeric derivatives of the three β-adrenolytics under microwave irradiation. TLC separation of diastereomeric derivatives was achieved which were then isolated by preparative approach; these were characterized and were used as standard reference for determining absolute configuration of diastereomeric derivatives and for establishing validated HPLC method for enantioseparation and sensitive detection of the three β-adrenolytics in human plasma...
July 14, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28724273/effects-of-inhaled-salbutamol-on-sport-specific-fitness-of-non-asthmatic-football-players
#2
Farzin Halabchi, Mahdi Abarashi, Mohammad Ali Mansournia, Tohid Seifbarghi
In this article, we investigated the effectiveness of inhaled salbutamol withtherapeutic dose on the sport-specific performance of non-asthmatic young football players. In a double-blinded, randomised placebo controlled trial with 2-treatment, 2-period crossover design, twenty participants who were non-asthmatic junior professional football players were randomly allocated to two groups. Fifteen minutes before sport-specific fitness testing, each group randomly received 2 inhalations (200 micrograms) of salbutamol or placebo, respectively...
May 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28723410/innovative-pmdi-formulations-of-spray-dried-nanoparticles-for-efficient-pulmonary-drug-delivery
#3
Hao-Ying Li, En-Yu Xu
For drug delivery to the lungs, the aerodynamic size of drug particles plays a predominant role in determining the sites of deposition in the airway, and the particles with the size less than 2 microns are highly expected as they will be preferably delivered to the ideal site of alveolar regions. In this paper, a novel platform technology has been developed, where the water (containing pharmaceutically active agents)-in-oil (w/o) microemulsions were spray-dried to generate nanosized drug particles that were able to be homogeneously dispersed in the propellant to form an exceptionally stable suspensions with no precipitates or flocculates during a long time storage...
July 16, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28719816/sulfate-radical-induced-degradation-of-%C3%AE-2-adrenoceptor-agonists-salbutamol-and-terbutaline-phenoxyl-radical-dependent-mechanisms
#4
Lei Zhou, Mohamad Sleiman, Corinne Ferronato, Jean-Marc Chovelon, Pascal de Sainte-Claire, Claire Richard
The present study investigated the reactivity and oxidation mechanisms of salbutamol (SAL) and terbutaline (TBL), two typical β2-adrenoceptor agonists, towards sulfate radical (SO4(-)) by using photo-activated persulfate (PS). The reaction pathways and mechanisms were proposed based on products identification using high resolution HPLC-ESI-MS, laser flash photolysis (LFP) and molecular orbital calculations. The results indicated that SO4(-) was the dominant reactive species in the UV/PS process. The second-order rate constants of sulfate radical reaction with SAL and TBL were measured as (3...
July 14, 2017: Water Research
https://www.readbyqxmd.com/read/28718249/frequency-of-undiagnosed-chronic-obstructive-pulmonary-disease-in-patients-with-coronary-artery-disease
#5
Raza Ullah, Shahid Salam, Tahir Ghaffar, Rahim Muhammad, Imran Khan
BACKGROUND: Chronic obstructive airway disease (COPD) is considered as risk factor for coronary artery disease (CAD) along with other risk factors. This study was conducted to determine the frequency of undiagnosed chronic obstructive pulmonary disease in patients with coronary artery disease. METHODS: This cross-sectional study was conducted in the Pulmonology and Cardiology wards/OPD's of Khyber Teaching Hospital Peshawar. Patients more than 35 years of age, diagnosed with CAD of either gender were included...
April 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28710850/efficacy-and-safety-of-beclomethasone-dipropionate-breath-actuated-or-metered-dose-inhaler-in-pediatric-patients-with-asthma
#6
M Vandewalker, L Hickey, C J Small
BACKGROUND: Breath-actuated inhalers (BAI) eliminate the need for hand-breath coordination and, therefore, simplify thedelivery of inhaled medication. OBJECTIVE: To evaluate the efficacy and safety of beclomethasone dipropionate BAI and metered-dose inhaler (MDI) versus placebo in pediatric patients ages 4-11 years with persistent asthma. METHODS: In this double-blind, double-dummy, phase III study, 628 children with persistent asthma were randomly assigned(1:1:1:1:1) to twice-daily beclomethasone dipropionate (BAI 80 micrograms/day, BAI 160 micrograms/day, MDI 80 micrograms/day, or MDI 160 micrograms/day) or to placebo...
July 14, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28709940/investigation-of-l-leucine-in-reducing-the-moisture-induced-deterioration-of-spray-dried-salbutamol-sulfate-power-for-inhalation
#7
Liang Li, Sharon Shui Yee Leung, Thomas Gengenbach, Jiaqi Yu, Ge Fiona Gao, Patricia Tang, Qi Tony Zhou, Hak-Kim Chan
The aim of this study was to investigate the ability of L-leucine (LL) in preventing moisture-induced deterioration in the in vitro aerosolization performance of spray-dried (SD) salbutamol sulfate (SS). Increasing mass fraction of LL (5-80%) were co-spray dried with SS, and the physicochemical properties of the powders were characterized by laser diffraction, X-ray powder diffraction (XRD) and dynamic vapour sorption (DVS). Furthermore, the surface morphology and chemistry of fine particles was analyzed by scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS)...
July 11, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28709466/effects-of-inhaled-hypertonic-7-saline-on-lung-function-test-in-preschool-children-with-cystic-fibrosis-results-of-a-crossover-randomized-clinical-trial
#8
Raffaella Nenna, Fabio Midulla, Caterina Lambiase, Giovanna De Castro, Anna Maria Zicari, Luciana Indinnimeo, Giuseppe Cimino, Patrizia Troiani, Serena Quattrucci, Giancarlo Tancredi
BACKGROUND: This crossover, randomized, double-blind study (conducted over a 32-week period) was performed to determine, in clinically stable Cystic fibrosis (CF) preschool children: the effects of 7% inhaled hypertonic saline on spirometry and interrupter resistance technique (Rint), and the possible side effects. METHODS: Twelve CF children (6M, mean age ± SD: 5.7 ± 0.8 yrs) were enrolled and randomly assigned to receive hypertonic saline (HS-4 ml 7% sodium chloride), or normal saline (NS-0...
July 15, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28701647/the-case-of-a-14-year-old-boy-who-experienced-anaphylaxis-due-to-jellyfish-mastigias-papua-ingestion
#9
Shohei Kubota, Asako Nozawa, Takanori Yanai, Koji Ozasa, Satomi Mori, Kazuyuki Kurihara
We report a case of jellyfish allergy diagnosed via an oral food challenge. A 14-year-old boy had no history of jellyfish stings and had been eating commercially available jellyfish products twice yearly for the past 5-6 years. Five minutes after eating a commercially available boiled jellyfish product (100g), he experienced nausea, wheezing, and erythema and had visited our hospital. We suspected an anaphylactic reaction and treated him with intramuscular adrenaline injection, corticosteroid and antihistamine infusions, volume resuscitation, and salbutamol sulfate inhalation, which resulted in an improvement of the symptoms...
2017: Arerugī, [Allergy]
https://www.readbyqxmd.com/read/28698672/metabolic-effects-of-clenbuterol-and-salbutamol-on-pork-meat-studied-using-internal-extractive-electrospray-ionization-mass-spectrometry
#10
Haiyan Lu, Hua Zhang, Tenggao Zhu, Yipo Xiao, Shaoxian Xie, Haiwei Gu, Meng Cui, Liping Luo
Direct mass spectrometry analysis of metabolic effects of clenbuterol and salbutamol on pork quality at the molecular level is incredibly beneficial for food regulations, public health and the development of new anti-obesity drugs. With internal extractive electrospray ionization mass spectrometry (iEESI-MS), nutrients including creatine, amino acids, L-carnitine, vitamin B6, carnosine and phosphatidylcholines in pork tissue were identified, without sample pretreatment, using collision-induced dissociation (CID) experiments and by comparison with authentic compounds...
July 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28696802/correlation-of-induced-sputum-eosinophil-levels-with-clinical-parameters-in-mild-and-moderate-persistent-asthma-in-children-aged-7-18%C3%A2-years
#11
Prachi Kansal, Devki Nandan, Sheetal Agarwal, Neha Patharia, Narendra Arya
BACKGROUND: Treatment decisions in asthma are currently based on clinical assessment and spirometry. Sputum eosinophil, being a marker of airway inflammation, can serve as a tool for assessing severity and response to treatment in asthma patients. OBJECTIVES: To measure eosinophil percentage in induced sputum in children with asthma and correlate it with clinical asthma parameters. METHODS: A prospective observational study was performed at tertiary care hospital on 91 children aged 7-18 years with newly diagnosed mild or moderate persistent asthma...
July 11, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28690392/congenital-myasthenic-syndrome-phenotypic-variability-in-patients-harbouring-p-t159p-mutation-in-chrne-gene
#12
Anna Ardissone, Isabella Moroni, Pia Bernasconi, Raffaella Brugnoni
Congenital myasthenic syndromes (CMS) are rare and heterogeneous genetic diseases characterized by compromised neuromuscular transmission and clinical features of fatigable weakness; age at onset, presenting symptoms, distribution of weakness, and response to treatment differ depending on the underlying molecular defect. Mutations in one of the multiple genes, encoding proteins expressed at the neuromuscular junction, are currently known to be associated with subtypes of CMS. The most common CMS syndrome identified is associated with mutation in the CHRNE gene, causing principally muscle nicotinic acetylcholine receptor deficiency, that results in reduced receptor density on the postsynaptic membrane...
March 2017: Acta Myologica: Myopathies and Cardiomyopathies: Official Journal of the Mediterranean Society of Myology
https://www.readbyqxmd.com/read/28685175/a-hybrid-molecularly-imprinted-polymer-coated-quantum-dot-nanocomposite-optosensor-for-highly-sensitive-and-selective-determination-of-salbutamol-in-animal-feeds-and-meat-samples
#13
Phannika Raksawong, Kochaporn Chullasat, Piyaluk Nurerk, Proespichaya Kanatharana, Frank Davis, Opas Bunkoed
A hybrid molecularly imprinted polymer (MIP)-coated quantum dot (QD) nanocomposite was synthesized and applied as a fluorescence probe for the highly sensitive and selective determination of salbutamol. The hybrid MIP-coated QD nanocomposite was synthesized via a copolymerization process in the presence of thioglycolic acid capped CdTe QDs with salbutamol as a template, 3-aminopropyltriethoxysilane as the functional monomer, and tetraethyl orthosilicate as a cross-linker. The optimum molar ratio of template, monomer, and cross-linker was 1:6:20...
July 6, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28672149/enantiomeric-profiling-of-a-chemically-diverse-mixture-of-chiral-pharmaceuticals-in-urban-water
#14
S Evans, J Bagnall, B Kasprzyk-Hordern
Due to concerns regarding the release of pharmaceuticals into the environment and the understudied impact of stereochemistry of pharmaceuticals on their fate and biological potency, we focussed in this paper on stereoselective transformation pathways of selected chiral pharmaceuticals (16 pairs) at both microcosm (receiving waters and activated sludge wastewater treatment simulating microcosms) and macrocosm (wastewater treatment plant (WWTP) utilising activated sludge technology and receiving waters) scales in order to test the hypothesis that biodegradation of chiral drugs is stereoselective...
June 30, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28670327/asthma-pressurised-metered-dose-inhaler-performance-propellant-effect-studies-in-delivery-systems
#15
William F S Sellers
BACKGROUND: Current pressurised metered dose asthma inhaler (pMDI) propellants are not inert pharmacologically as were previous chlorofluorocarbons, have smooth muscle relaxant' partial pressure effects in the lungs and inhaled hydrofluoroalkane 134a (norflurane) has anaesthetic effects. Volumes of propellant gas per actuation have never been measured. METHODS: In-vitro studies measured gas volumes produced by pMDIs on air oxygen (O2) levels in valved holding chambers (VHC) and the falls in O2% following actuation into lung ventilator delivery devices...
2017: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/28668232/effect-of-salbutamol-on-respiratory-muscle-strength-in-spinal-muscular-atrophy
#16
Sonia Khirani, Ivana Dabaj, Alessandro Amaddeo, Jorge Olmo Arroyo, Jacques Ropers, Stéphane Tirolien, Véronique Coudert, Brigitte Estournet, Brigitte Fauroux, Susana Quijano-Roy
BACKGROUND: Oral salbutamol has shown clinical benefits in spinal muscular atrophy (SMA). We studied its effect on the respiratory muscle strength in children with different types of SMA. METHODS: Lung and respiratory muscle functions were assessed in children receiving daily oral salbutamol for at least one year. The respiratory data of age-matched SMA II historical control subjects were compared with data of SMA II patients receiving salbutamol. RESULTS: Seven children (6...
April 20, 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/28665534/bronchoprotective-tolerance-with-indacaterol-is-not-modified-by-concomitant-tiotropium-in-persistent-asthma
#17
Sunny Jabbal, Arvind Manoharan, Brian Lipworth
BACKGROUND: Tiotropium is a long acting antimuscarinic (LAMA), licenced as triple therapy with inhaled corticosteroid and long acting beta-agonist (ICS/LABA). There may be a synergistic benefit between LAMA and LABA as a consequence of receptor cross-talk, which in turn could modify beta-2 receptor down-regulation and associated tolerance induced by LABA. OBJECTIVE: We hypothesise this mechanism may result in a reduction of airway hyperresponsiveness (AHR) when using triple therapy...
June 30, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28652557/study-of-ph-stability-of-r-salbutamol-sulfate-aerosol-solution-and-its-antiasthmatic-effects-in-guinea-pigs
#18
Qing Liu, Qingrui Li, Ting Han, Tingting Hu, Xuemei Zhang, Junhua Hu, Hui Hu, Wen Tan
Currently, all commercial available nebulized Salbutamol in China is in its racemic form. It is known that only R-salbutamol (eutomer) has therapeutic effects, while S-salbutamol (distomer) may exacerbate asthma after chronic use. Therefore, it is an unmet clinical need to develop R-salbutamol as a nebulized product that is more convenient for young and old patients. In our study, a stable aerosol solution of R-salbutamol sulfate was established, and its antiasthmatic effects were confirmed. The decomposition rate and racemization effect of the R-salbutamol sulfate solution were evaluated over a pH range from 1 to 10 (except pH = 7, 8) at 60 ℃...
June 24, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28642308/predicting-risk-of-undiagnosed-copd-development-and-validation-of-the-targetcopd-score
#19
Shamil Haroon, Peymane Adab, Richard D Riley, David Fitzmaurice, Rachel E Jordan
Chronic obstructive pulmonary disease (COPD) is greatly underdiagnosed worldwide and more efficient methods of case-finding are required. We developed and externally validated a risk score to identify undiagnosed COPD using primary care records.We conducted a retrospective cohort analysis of a pragmatic cluster randomised controlled case-finding trial in the West Midlands, UK. Participants aged 40-79 years with no prior diagnosis of COPD received a postal or opportunistic screening questionnaire. Those reporting chronic respiratory symptoms were assessed with spirometry...
June 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28628545/salbutamol-therapy-for-food-impaction-in-eosinophilic-oesophagitis
#20
Jorge Amil Dias, Sofia Fernandes, Susana Corujeira, Eunice Trindade, Marta Tavares, Simon Murch
No abstract text is available yet for this article.
June 16, 2017: Journal of Pediatric Gastroenterology and Nutrition
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