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https://www.readbyqxmd.com/read/27898948/%C3%AE-and-%C3%AE-adrenergic-receptors-stimulation-relaxes-porcine-myometrium-in-the-peri-implantation-period
#1
W Markiewicz, J J Jaroszewski
These studies were to demonstrate whether the β-receptor is involved in regulating the contractility of the swine myometrium in the peri-implantation period and to compare a relaxing activity of selective β- and β-adrenergic agonists (salbutamol and BRL 37344, respectively). Myometrial strips were collected form the gilts ( = 8) on d 12 to 14 of pregnancy. Changes in the contractility of myometrial strips were assessed further to the administration of increasing concentrations of the agonists (10 to 10 ) with and without β-adrenergic receptor antagonists: butoxamine, propranolol, and bupranolol at 10 ...
November 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27898378/ag-n-doped-reduced-graphene-oxide-incorporated-with-molecularly-imprinted-polymer-an-advanced-electrochemical-sensing-platform-for-salbutamol-determination
#2
Junhua Li, Zhifeng Xu, Mengqin Liu, Peihong Deng, Siping Tang, Jianbo Jiang, Haibo Feng, Dong Qian, Lingzhi He
In this work, the metallic silver and non-metallic nitrogen co-doped reduced graphene oxide (Ag-N-RGO) was first synthesized by a simple and cost-effective strategy, and then a molecularly imprinted polymer (MIP) was formed in situ at the surface of the prepared composite via electropolymerization of o-phenylenediamine in the presence of salbutamol as the template molecule. The electrochemical characterizations demonstrate that the bifunctional graphene-based composite shows improved catalytic performance than that of pristine graphene doped with one-component or none...
November 10, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27892438/comparison-of-initial-response-of-nebulized-salbutamol-and-adrenaline-in-infants-and-young-children-admitted-with-acute-bronchiolitis
#3
S Adhikari, P Thapa, K S Rao, G Bk
Background Acute bronchiolitis is common cause of hospitalization in infants and young children. There are widespread variations in the diagnosis and management. Despite the use of bronchodilators for decades, there is lack of consensus for the benefit of one above another. Objective To compare initial response of nebulized adrenaline and salbutamol. Method Children aged two months to two years admitted with acute bronchiolitis in the department of Paediatrics of Manipal teaching hospital, Pokhara, Nepal, from 1st March 2014 to 28th February 2015 were enrolled...
January 2016: Kathmandu University Medical Journal (KUMJ)
https://www.readbyqxmd.com/read/27888987/free-asthma-medications-reduces-hospital-admissions-in-brazil-free%C3%A2-asthma-drugs-reduces-hospitalizations-in-brazil
#4
Talitha Comaru, Paulo Márcio Pitrez, Frederico Orlando Friedrich, Victória D Silveira, Leonardo A Pinto
BACKGROUND: Since June 2011, the Brazilian health system started providing asthma medications (beclomethasone and salbutamol), totally free of charge to patients with asthma. The aim of this study was to evaluate the impact of the provision of free asthma medications on hospital admissions for asthma in Brazil, using a national hospitalization database (DATASUS), comparing the incidence of hospital admissions before and after the free supply of these drugs. METHODS: Admissions of patients with 1-49 years of age by the Brazilian public health system with the diagnosis of asthma were compared pre (2008-2010) and post (2012-2014) provision of free medicines (beclomethasone and salbutamol)...
December 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27888478/examining-the-quality-of-medicines-at-kenyan-healthcare-facilities-a-validation-of-an-alternative-post-market-surveillance-model-that-uses-standardized-patients
#5
Francis Wafula, Amy Dolinger, Benjamin Daniels, Njeri Mwaura, Guadalupe Bedoya, Khama Rogo, Ana Goicoechea, Jishnu Das, Bernard Olayo
BACKGROUND: Promoting access to medicines requires concurrent efforts to strengthen quality assurance for sustained impact. Although problems of substandard and falsified medicines have been documented in low- and middle-income countries, reliable information on quality is rarely available. OBJECTIVE: The aim of this study was to validate an alternative post-market surveillance model to complement existing models. METHODS: The study used standardized patients or mystery clients (people recruited from the local community and trained to pose as real patients) to collect medicine samples after presenting a pre-specified condition...
November 25, 2016: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/27866986/modelling-of-in-vitro-and-in-vivo-performance-of-aerosol-emitted-from-different-vibrating-mesh-nebulisers-in-non-invasive-ventilation-circuit
#6
Hoda Rabea, Ahmed M A Ali, Randa Salah Eldin, Maha M Abdelrahman, Amira S A Said, Mohamed E Abdelrahim
Substituting nebulisers by another in non-invasive ventilation circuit (NIV) involves many process variables which must be adjusted to ensure patient optimum therapy. However, there is a doubt when nebulisers use the same technology. Data mining technology based on artificial neural networks and genetic algorithms were used here to model in-vitro inhalation process and predict bioavailability from inhaled doses delivered by three different vibrating mesh nebulisers (VMNs) in NIV. Modelling of data indicated that in-vitro performance of VMNs was dependent mainly on fine particle fraction, mass median aerodynamic diameter (MMAD), total emitted dose (TED) and to lesser extent on nebuliser type...
November 17, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27859454/rapid-analysis-of-interaction-between-six-drugs-and-%C3%AE-2-adrenergic-receptor-by-injection-amount-dependent-method
#7
Kaizhu Zeng, Jing Wang, Zhenyu Sun, Qian Li, Sha Liao, Xinfeng Zhao, Xiaohui Zheng
Drug-protein interaction analysis has become a considerable topic in life science which includes clarifying protein functions, explaining drug action mechanisms and uncovering novel drug candidates. This work was to determine the association constants (KA ) of six drugs to β2 -adrenergic receptor by injection amount dependent method using stationary phase containing the immobilized receptor. The association constants (KA ) were calculated to be (25.85 ± 0.035) × 10(4)  M(-1) for clorprenaline, (42...
November 15, 2016: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/27836009/how-can-we-optimise-inhaled-beta2-agonist-dose-as-reliever-medicine-for-wheezy-pre-school-children-study-protocol-for-a-randomised-controlled-trial
#8
Somnath Mukhopadhyay, Paul Seddon, Gemma Earl, Emma Wileman, Liz Symes, Cathy Olden, Corinne Alberti, Stephen Bremner, Alison Lansley, Colin N A Palmer, Nicole Beydon
BACKGROUND: Asthma is a common problem in children and, if inadequately controlled, may seriously diminish their quality of life. Inhaled short-acting beta2 agonists such as salbutamol are usually prescribed as 'reliever' medication to help control day-to-day symptoms such as wheeze. As with many medications currently prescribed for younger children (defined as those aged 2 years 6 months to 6 years 11 months), there has been no pre-licensing age-specific pharmacological testing; consequently, the doses currently prescribed (200-1000 μg) may be ineffective or likely to induce unnecessary side effects...
November 11, 2016: Trials
https://www.readbyqxmd.com/read/27833558/serelaxin-elicits-bronchodilation-and-enhances-%C3%AE-adrenoceptor-mediated-airway-relaxation
#9
Maggie Lam, Simon G Royce, Chantal Donovan, Maria Jelinic, Laura J Parry, Chrishan S Samuel, Jane E Bourke
Treatment with β-adrenoceptor agonists does not fully overcome the symptoms associated with severe asthma. Serelaxin elicits potent uterine and vascular relaxation via its cognate receptor, RXFP1, and nitric oxide (NO) signaling, and is being clinically evaluated for the treatment of acute heart failure. However, its direct bronchodilator efficacy has yet to be explored. Tracheal rings were prepared from male Sprague-Dawley rats (250-350 g) and tricolor guinea pigs, and precision cut lung slices (PCLSs) containing intrapulmonary airways were prepared from rats only...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27832943/evaluation-of-the-anti-inflammatory-effects-of-%C3%AE-adrenoceptor-agonists-on-human-lung-macrophages
#10
Sharonjit K Gill, Helen M Marriott, S Kim Suvarna, Peter T Peachell
The principal mechanism by which bronchodilator β-adrenoceptor agonists act is to relax airways smooth muscle although they may also be anti-inflammatory. However, the extent of anti-inflammatory activity and the cell types affected by these agonists are uncertain. The purpose of this study was to evaluate whether β-adrenoceptor agonists prevent pro-inflammatory cytokine generation from activated human lung macrophages. Macrophages were isolated and purified from human lung. The cells were pre-treated with both short-acting (isoprenaline, salbutamol, terbutaline) and long-acting (formoterol, salmeterol, indacaterol) β-agonists before activation with lipopolysaccharide (LPS) to induce cytokine (TNFα, IL-6, IL-8 and IL-10) generation...
November 7, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27825644/-variability-and-suitability-of-anti-asmathic-treatment-in-pediatric-primary-health-care
#11
Cristina Suárez-Castañón, Gracia Modroño-Riaño, Gonzalo Solís-Sánchez
OBJECTIVE: To analyse the use patterns and the characteristics of anti-asmathic prescriptions in pediatric primary health care. DESIGN: Observational and retrospective study. LOCATION: Pediatric primary health care, Asturias, Spain. PARTICIPANTS: Drug prescriptions in respiratory diseases in children (<14years old) during 2011. PRINCIPAL MEASUREMENTS: Data obtained from the billing database of the Regional Health Service of Asturias and analysed by sanitary district and primary health centres, calculating the number of DDD/1...
November 5, 2016: Atencion Primaria
https://www.readbyqxmd.com/read/27820869/spontaneous-breathing-pattern-as-respiratory-functional-outcome-in-children-with-spinal-muscular-atrophy-sma
#12
A LoMauro, A Aliverti, C Mastella, M T Arnoldi, P Banfi, G Baranello
INTRODUCTION: SMA is characterised by progressive motor and respiratory muscle weakness. We aimed to verify if in SMA children 1)each form is characterized by specific ventilatory and thoraco-abdominal pattern(VTAp) during quiet breathing(QB); 2)VTAp is affected by salbutamol therapy, currently suggested as standard treatment, or by the natural history(NH) of SMA; 3)the severity of global motor impairment linearly correlates with VTAp. MATERIALS AND METHODS: VTAp was analysed on 32 SMA type I (SMA1,the most severe form), 51 type II (SMA2,the moderate), 8 type III (SMA3,the mildest) and 20 healthy (HC) using opto-electronic plethysmography...
2016: PloS One
https://www.readbyqxmd.com/read/27811394/sympathetic-neurotransmitters-promote-the-process-of-recellularization-in-decellularized-liver-matrix-via-activating-the-il-6-stat3-pathway
#13
Xudong Wen, Hongbo Huan, Xiaojun Wang, Xuejiao Chen, Lili Wu, Yujun Zhang, Weihui Liu, Ping Bie, Feng Xia
Recellularized liver, as an approach for hepatic tissue engineering, is an effective alternative to orthotopic liver transplantation for end-stage hepatic failure. When compared with normal liver, recellularized liver has a disparity in hepatocyte viability and function, owing to the difficulty of fully simulating the microenvironment of liver. Although the sympathetic nervous system (SNS) is considered an important constituent of liver function, few studies have examined the effect of the SNS on hepatic tissue engineering...
November 4, 2016: Biomedical Materials
https://www.readbyqxmd.com/read/27793870/takotsubo-cardiomyopathy-with-use-of-salbutamol-nebulisation-and-aminophylline-infusion-in-a-patient-with-acute-asthma-exacerbation
#14
Yousuf Hasan Khwaja, Javed Majid Tai
Takotsubo cardiomyopathy, apical ballooning syndrome or stress-induced cardiomyopathy is characterised by transient left ventricular dysfunction, mimicking myocardial infarction in the absence of obstructive coronary artery disease or acute plaque rupture on coronary angiography. The exact mechanism of myocardial dysfunction in Takotsubo cardiomyopathy is unknown; however, due to its association with physical and emotional stress, it is postulated that catecholamines play a central role in its pathogenesis...
October 28, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27790333/a-multi-strain-synbiotic-may-reduce-viral-respiratory-infections-in-asthmatic-children-a-randomized-controlled-trial
#15
Hamid Ahanchian, Seyed Ali Jafari, Elham Ansari, Toktam Ganji, Mohammad Ali Kiani, Maryam Khalesi, Tooba Momen, Hamidreza Kianifar
BACKGROUND AND OBJECTIVE: Asthma is a growing problem worldwide. Acute exacerbations impose considerable morbidity, mortality, and increased cost. Viral respiratory infections are the most common cause (80-85%) of pediatric asthma exacerbations and admissions to the hospital. The aim of this study was to determine the effect of a new synbiotic Lactocare® on viral respiratory infections and asthma exacerbations in asthmatic children. METHODS: In this double blind, placebo-controlled, randomized clinical trial, 72 children with mild persistent asthma, aged between 6 and 12 years, were randomized to receive either Lactocare®, a Synbiotic containing 1 billion CFU/Capsule of Lactobacillus casei, Lactobacillus rhamnosus, Streptococcus thermophilus, Bifidobacterium breve, Lactobacillus acidophilus, Bifidobacterium infantis, Lactobacillus bulgaricus, and Fructooligosacharide (Zist Takhmir, Tehran, Iran) or placebo daily for 60 days...
September 2016: Electronic Physician
https://www.readbyqxmd.com/read/27784211/development-of-salbutamol-sulphate-sublingual-films-in-pullulan-matrix-for-enhanced-bioavailability-clinical-efficacy
#16
Nahed Sallam, Rania Sanad, Rasha Kharshoom, Mokhles Zeneldin
BACKGROUND: Salbutamol sulphate (SS) is a model short-acting β2-adrenergic receptor agonist used for the relief of bronchospasm having poor bioavailability (50%) due to its extensive first-pass effect. OBJECTIVE: Formulation of SS as fast dissolving sublingual films (FDSFs) using a biocompatible and biodegradable Pullulan polymer to bypass its metabolism in liver and offers a fast relieve of asthma. METHOD: Films were prepared by solvent casting technique adopting 32 factorial design to study the effect of two independent variables namely; polymer type (HPMC E5, Pullulan, and L-HPC) and polymer to Maltodextrin ratio (3:0, 3:1 or 5:1)...
October 24, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/27771799/salbutamol-effects-on-systemic-potassium-dynamics-during-and-following-intense-continuous-and-intermittent-exercise
#17
Muath M Altarawneh, Aaron Petersen, Robert Smith, David M Rouffet, Francois Billaut, Ben D Perry, Victoria L Wyckelsma, Antony Tobin, Michael J McKenna
PURPOSE: Salbutamol inhalation is permissible by WADA in athletic competition for asthma management and affects potassium regulation, which is vital for muscle function. Salbutamol effects on arterial potassium concentration ([K(+)]a) during and after high-intensity continuous exercise (HIcont) and intermittent exercise comprising repeated, brief sprints (HIint), and on performance during HIint are unknown and were investigated. METHODS: Seven recreationally active men participated in a double-blind, randomised, cross-over design, inhaling 1000 µg salbutamol or placebo...
October 22, 2016: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/27762156/strategies-for-managing-transient-tachypnoea-of-the-newborn-a-systematic-review
#18
Ashok Buchiboyina, Bonny Jasani, Mangesh Deshmukh, Sanjay Patole
OBJECTIVE: To conduct a systematic review of strategies for the management of transient tachypnoea of the newborn (TTN). METHODS: The Cochrane Collaboration and PRISMA guidelines were used for conducting and reporting this systematic review, respectively. The Cochrane Central Register of Controlled Trials, PubMed, CINAHL and EMBASE databases were searched in February 2016. Only randomised and quasi-randomised controlled trials (RCTs) assessing any intervention for the management of TTN in infants <7 days of age, born at 35 or more weeks with a clinical diagnosis of TTN were eligible for inclusion...
October 20, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27742871/assessing-bronchodilator-response-in-preschool-children-using-spirometry
#19
Luciano E Busi, Sebastián Restuccia, Ricardo Tourres, Peter D Sly
BACKGROUND: Measuring lung function, including bronchodilator response (BDR), is an integral part of asthma management in older children. While spirometry is possible in preschool-aged children, the question remains whether measuring BDR aids in asthma diagnosis in this age group. METHODS: 431 healthy children and 289 children with asthma, aged 3-5 years, were recruited from kindergartens and the pulmonology clinic in Trelew, Argentina. Spirometry was performed at visit 1 and repeated after 15 min, with children randomised to placebo or salbutamol (400 µg)...
October 14, 2016: Thorax
https://www.readbyqxmd.com/read/27730746/distinct-metabolic-profile-of-inhaled-budesonide-and-salbutamol-in-asthmatic-children-during-acute-exacerbation
#20
Yang Quan-Jun, Zhang Jian-Ping, Zhang Jian-Hua, Han Yong-Long, Xin Bo, Zhang Jing-Xian, Dai Bona, Zhang Yuan, Guo Cheng
Inhaled budesonide and salbutamol represent the most important and frequently used drugs in asthmatic children during acute exacerbation. However, there is still no consensus about their resulting metabolic derangements; thus, the present study was conducted to determine the distinct metabolic profiles of these two drugs. A total of 69 children with asthma during acute exacerbation were included, and their serum and urine were investigated using high-resolution nuclear magnetic resonance (NMR). A metabolomics analysis was performed using a principal component analysis and orthogonal signal correction-partial least squares using SIMCA-P...
October 12, 2016: Basic & Clinical Pharmacology & Toxicology
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