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Catherine A Marco, William Trautman, Alexander Cook, Dennis Mann, Jordan Rasp, Oswald Perkins, Michael Ballester
BACKGROUND: Emergency department (ED) visits for unintentional opioid overdoses have increased dramatically. Naloxone hydrochloride (Narcan®) is an opioid antagonist commonly used to treat these overdoses. OBJECTIVE: This study was undertaken to identify experiences regarding naloxone use among ED patients with opioid overdose. METHODS: This prospective survey study was conducted at an urban level I trauma center. A survey was administered to eligible ED patients after unintentional opioid overdose...
May 16, 2018: Journal of Emergency Medicine
Kelly E Dunn, Frederick S Barrett, George E Bigelow
BACKGROUND: Opioid-related overdose has increased 137% in the past decade. Training nonmedical bystanders to administer naloxone (Narcan™) is a widely-researched intervention that has been associated with decreases in overdose rates in the communities in which it has been implemented. A recent review advocated for noninjectable formulations of naloxone, however patient preference for naloxone formulations has not yet been examined (Strang et al., 2016). METHODS: Two cohorts of respondents (N1  = 501, N2  = 172) who reported currently being prescribed an opioid for pain management were recruited through the crowd-sourcing program Amazon Mechanical Turk (MTurk) to assess their preference for naloxone formulations...
March 28, 2018: Addictive Behaviors
Susan A Salladay
No abstract text is available yet for this article.
April 2018: Journal of Christian Nursing: a Quarterly Publication of Nurses Christian Fellowship
Dorothy James Moore
No abstract text is available yet for this article.
October 2017: Journal of Addictions Nursing
Rebecca McDonald, Nancy D Campbell, John Strang
BACKGROUND: Opioid overdose is a major cause of mortality, but injury and fatal outcomes can be prevented by timely administration of the opioid antagonist naloxone. Pre-provision of naloxone to opioid users and family members (take-home naloxone, THN) was first proposed in 1996, and WHO Guidelines were issued in 2014. While widespread in some countries, THN is minimally available or absent elsewhere. This review traces the development of THN over twenty years, from speculative harm reduction proposal to public health strategy...
September 1, 2017: Drug and Alcohol Dependence
George K Avetian, Phillip Fiuty, Silvana Mazzella, Dave Koppa, Vivian Heye, Pratibha Hebbar
OBJECTIVE: Naloxone hydrochloride, an opioid antagonist, has been approved as a concentrated 4 mg dose intranasal formulation for the emergency treatment of known or suspected opioid overdose. This new formulation is easier to use and contains a higher dose of naloxone compared with earlier, unapproved kits. A survey of first responders and community-based organizations was conducted to understand initial real-world experiences with this new formulation for opioid overdose reversal...
April 2018: Current Medical Research and Opinion
John F Kelly, Nilo Fallah-Sohy, Julie Cristello, Brandon Bergman
BACKGROUND: Opioid overdose deaths have become a major public health crisis. While efforts have focused mostly on helping opioid-addicted individuals directly, family members suffer also from the grave and enduring unpredictability associated with opioid addiction and often play a vital role in helping addicted loved ones access care. Little is known, however, about resources to help affected family members. Here we describe results from the first quantitative and qualitative investigation of a free and growing support organization for family members of addicted individuals ("Learn to Cope" [LTC]; www...
June 2017: Journal of Substance Abuse Treatment
Gyanendra Acharya, Sunil Mehra, Ronakkumar Patel, Simona Frunza-Stefan, Harmanjot Kaur
Bariatric surgery is well established in reducing weight and improving the obesity-associated morbidity and mortality. Hyperammonemic encephalopathy following bariatric surgery is rare but highly fatal if not diagnosed in time and managed aggressively. Both macro- and micronutrients deficiencies play a role. A 42-year-old Hispanic female with a history of Roux-en-Y Gastric Bypass Procedure was brought to ED for progressive altered mental status. Physical exam was remarkable for drowsiness with Glasgow Coma Scale 11, ascites, and bilateral pedal edema...
2016: Case Reports in Critical Care
(no author information available yet)
No abstract text is available yet for this article.
January 4, 2016: Medical Letter on Drugs and Therapeutics
Katherine Harmon, Amy Ising, Scott Proescholdbell, Clifton Barnett, Steve Marshall, Anna Waller
STATEMENT OF PURPOSE: The NC Division of Public Health, in collaboration with UNC Chapel Hill, is improving injury surveillance data as part of the NC Surveillance Quality Improvement (SQI) Project. The project has focused on improving emergency department (ED) data in the statewide public health surveillance system NC DETECT. Unlike statewide mortality and hospital discharge data, NC DETECT ED data are available in near real time with over 75% of ED visits assigned at least one billing code within two weeks of the visit...
April 2015: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
Mark Faul, Michael W Dailey, David E Sugerman, Scott M Sasser, Benjamin Levy, Len J Paulozzi
OBJECTIVES: We determined the factors that affect naloxone (Narcan) administration in drug overdoses, including the certification level of emergency medical technicians (EMTs). METHODS: In 2012, 42 states contributed all or a portion of their ambulatory data to the National Emergency Medical Services Information System. We used a logistic regression model to measure the association between naloxone administration and emergency medical services certification level, age, gender, geographic location, and patient primary symptom...
July 2015: American Journal of Public Health
(no author information available yet)
No abstract text is available yet for this article.
September 2014: Rhode Island Medical Journal
Matthew Zuckerman, Stacy N Weisberg, Edward W Boyer
No abstract text is available yet for this article.
January 2015: Prehospital Emergency Care
(no author information available yet)
No abstract text is available yet for this article.
April 2014: Rhode Island Medical Journal
Shiayin Yang, Youngsook Yoon
SESSION TYPE: Critical Care Student/Resident Case Report Posters IIPRESENTED ON: Tuesday, October 23, 2012 at 01:30 PM - 02:30 PMINTRODUCTION: Intensive care patients often have multiple comorbidities and very complex treatment plans. Pinpointing an exact precipitating factor responsible for a patient's rapid health decline is difficult. Late or inappropriate identification can further complicate the picture. Swift action and maintaining a broad differential is paramount in order to correctly identify the cause and treat appropriately...
October 1, 2012: Chest
Peter C Britton, Amy S B Bohnert, James D Wines, Kenneth R Conner
OBJECTIVE: The purpose of this study is to develop a procedure for assessing unintentional overdose (OD) in opiate abusers that differentiates it from intentional OD, and provides reliable information about the incident. METHODS: A sample of 121 patients in a methadone maintenance program at an urban university hospital completed a baseline assessment. A total of 70 participants completed an identical assessment at least 14 days later. The ability of an OD item to differentiate unintentional OD from intentional OD was tested, as was the test-retest reliability of questions assessing symptoms and treatment of OD...
January 2012: Addictive Behaviors
Robert H Howland
Blocking dopamine (DA) receptors in the basal ganglia can cause parkinsonian symptoms, acute dystonia, akathisia, tardive dyskinesia (TD), and neuroleptic malignant syndrome. TD is characterized by abnormal, involuntary, irregular motor movements involving muscles of the head, limbs, or trunk. Many drug therapies have been tried for TD, but none are approved by the U.S. Food and Drug Administration. The second-generation antipsychotic drugs should be considered as a treatment of first choice for clinically significant TD, because they will also be potentially effective as a primary treatment for the underlying disorder...
June 2011: Journal of Psychosocial Nursing and Mental Health Services
Robert H Howland
Opioid receptors are widely distributed throughout the nervous system. In addition to their central role in brain pathways mediating pain, endogenous opioid peptides function as neuromodulators and opioid systems are involved in many physiological functions. Opioid receptor drugs, including methadone (Dolophine), buprenorphine (Buprenex, Subutex), naltrexone (Revia), naloxone (Narcan), and buprenorphine/naloxone (Suboxone), are the focus of this article. This class of drugs is likely to be further developed for the treatment of addictions and mood disorders...
May 2010: Journal of Psychosocial Nursing and Mental Health Services
Karen Barker, Don Hunjadi
They wake the unconscious, cure the very ill and even rescue patients from death's door. They're miracle drugs, and thousands of ambulance services across the country carry them. For those onlookers and new EMS providers who see a patient wake up from a deep, unconscious state, it's a captivating experience. The most common of these drugs is dextrose. But there's another--meet Narcan.
August 2008: JEMS: a Journal of Emergency Medical Services
Debra Kerr, Paul Dietze, Anne-Maree Kelly
AIMS: This paper reviews available literature regarding the effectiveness, safety and utility of intranasal (i.n.) naloxone for the treatment of heroin overdose. METHODS: Scientific literature in the form of published articles during the period January 1984 to August 2007 were identified by searching several databases including Medline, Cinahl and Embase for the following terms: naloxone, narcan, intranasal, nose. The data extracted included study design, patient selection, numbers, outcomes and adverse events...
March 2008: Addiction
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