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Hamed Fathi, Mohammad Alli Ebrahimzadeh, Ali Ziar, Hamidreza Mohammadi
Nausea and vomiting are the most common symptoms in different diseases. Medicinal plants are considered as a reliable source of new drugs to control these symptoms. In this study, we evaluated the antiemetic and neuroprotective effects of the methanolic extract of Sambucus ebulus L. fruit and relationship between emesis (retching) and oxidative stress biomarkers in the mitochondria brain of young chickens. Emesis was induced by ipecac and copper sulphate (60 and 600 mg/kg, orally), respectively, and the methanolic extracts (50, 100, 200 mg/kg) were injected intraperitoneally (i...
October 2015: Cell Biology and Toxicology
Ayhan Yaman, Tanıl Kendirli, Çağlar Ödek, Caner Yıldız, Fırat Beğde, Hatice Erkol, Erdal İnce
Neuroleptic malignant syndrome (NMS) is a rare but potentially fatal complication of treatment with antipsychotic medication. NMS has also been associated with non-neuroleptic agents that block central dopamine pathways, such as metoclopramide, amoxapine and lithium. Metoclopromide has antidopaminergic properties and is a rare but well-recognized perpetrator in the development of NMS. NMS has a constellation of signs and symptoms, including hyperthermia, muscle rigidity, autonomic instability, tachycardia, tachypnea, diaphoresis, hypertension and altered mental status...
September 2014: Turkish Journal of Pediatrics
Mohammadreza Safavi, Azim Honarmand, Alireza Yazdanpanah
BACKGROUND: Metoclopromide have local anesthetic properties. The main object of performing the present study was to evaluate the analgesic effect of metoclopromide 10 mg when added to lidocaine for intravenous regional anesthesia (IVRA) of upper extremities in trauma patients. MATERIALS AND METHODS: Ninety patients undergoing upper limb producer were randomly allocated to the three groups to receive 3 mg/kg 2% lidocaine diluted with saline to a total dose of 40 ml (Group L, n = 30) or 10 mg metoclopromide plus 3 mg/kg 2% lidocaine diluted with saline to a total dose of 40 ml (group LM, n = 30) or 3 mg/kg 2% lidocaine diluted with saline to a total dose of 40 ml plus 10 mg metoclopromide intravenously (Group IM, n = 30)...
2014: Advanced Biomedical Research
Weiwu Pang, Yu-Cheng Liu, Edgard Maboudou, Tom Xianxiu Chen, John M Chois, Cheng-Chun Liao, Rick Sai-Chuen Wu
OBJECTIVE: Multimodal analgesia has been effectively used in postoperative pain control. Tramadol can be considered "multimodal" because it has two main mechanisms of action, an opioid agonist and a reuptake inhibitor of norepinephrine and serotonin. Tramadol is not as commonly used as morphine due to the increased incidence of postoperative nausea and vomiting (PONV). As metoclopramide is an antiemetic and an analgesic, it was hypothesized that when added to reduce PONV, metoclopromide may enhance the multimodal feature of tramadol by the analgesic property of metoclopramide...
September 2013: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
Mehrdad Kashifard, Zahra Basirat, Maede Kashifard, Masoumeh Golsorkhtabar-Amiri, Aliakbar Moghaddamnia
BACKGROUND: Nausea and vomiting of pregnancy (NVP) are seen in 50-80% of pregnancies. However, in severe NVP, called hypermesis gravidarum (HG), medical therapy to reduce nausea and vomiting is inevitable and ondansetron (OND) as an effective drug has recently been proposed. This study evaluated the effectiveness of OND versus metoclopramide (MET) in the treatment of HG. METHODS: In this clinical trial study, 83 pregnant women with HG were enrolled in 2011-2012 and randomly divided in two groups...
2013: Clinical and Experimental Obstetrics & Gynecology
J E Finch, M J Kendall, M Mitchard
1 A breathalyser has been used to measure blood alcohol levels at short intervals to produce an absorption curve which we have shown is reproducible. 2 Changes in the rate of absorption which reflect changes in gastric emptying times produced by metoclopromide and propantheline have been demonstrated. 3 The breathalyser technique described appears to offer a simple method of studying the effects of drugs on the rate of gastric emptying.
June 1974: British Journal of Clinical Pharmacology
Darshit A Thaker, Bruce C Stafford, Luke S Gaffney
Mr. P was a 57-year-old man who presented with symptoms of bowel obstruction in the setting of a known metastatic pancreatic cancer. Diagnosis of malignant bowel obstruction was made clinically and radiologically and he was treated conservatively (non-operatively)with octreotide, metoclopromide and dexamethasone, which provided good control over symptoms and allowed him to have quality time with family until he died few weeks later with liver failure. Bowel obstruction in patients with abdominal malignancy requires careful assessment...
May 2010: Indian Journal of Palliative Care
Shipra Sonkusare
Hyperemesis gravidarum is a severe and disabling condition with potentially life-threatening complications. It is likely to have a multifactorial etiology which contributes to the difficulty in treatment. Treatment is supportive with correction of dehydration and electrolyte disturbance, antiemetic therapy, prevention and treatment of complications like Wernicke's encephalopathy, osmotic demyelination syndrome, thromboembolism, and good psychological support. There are abundant data on the safety of antihistamines, phenothiazines, and metoclopromide in early pregnancy and treatment should therefore not be withheld on the basis of teratogenicity concerns...
June 2011: Archives of Gynecology and Obstetrics
Young Seok Jee, Hea-Jo Yoon, Chang-Ha Jang
BACKGROUND: This study was conducted to compare the efficacy of a combination of ondansetron and dexamethasone with that of metoclopramide and dexamethasone for prevention of postoperative nausea and vomiting (PONV) in gynecologic patients receiving fentanyl IV-patient controlled analgesia. METHODS: One hundred patients were divided into two groups at random. In Group O, 5 mg of dexamethsone was administered after tracheal intubation, while 4 mg of ondansetron was administered at the end of surgery...
November 2010: Korean Journal of Anesthesiology
Hitendra Shaligram Mahajan, Surendra Ganeshlal Gattani
The purpose of this study was to develop nasal microparticles of metoclopromide employing gellan gum as a polymer by spray drying method. This method of microencapsulation is particularly less dependent on the solubility characteristics of the drug and polymer and is simple, reproducible, and easy to scale up. The microparticles were evaluated for characteristics like particle size, incorporation efficiency, swelling ability, zeta potential, mucoadhesion, thermal analysis, X-ray diffraction (XRD) study and in vitro drug release...
April 2009: Chemical & Pharmaceutical Bulletin
Alexandre Guilherme Zabeu Rossi, Regina Célia Teixeira Gomes, Manuel de Jesus Simões, Ricardo Dos Santos Simões, Patrícia B Oliveira, José Maria Soares, Edmund C Baracat
OBJECTIVE: To evaluate the effects of metoclopramide-induced hyperprolactinemia on the prolactin receptor of murine endometrium. DESIGN: Experimental study using the RNA extraction to detect tissue prolactin receptor isoforms by reverse-transcriptase polymerase chain reaction (RT-PCR). SETTING: University-based laboratory. ANIMAL(S): Seventy-two female swiss albino mice (Mus musculus), approximately 100 days old, were divided into six 12-animal groups: (GI) nonoophorectomized mice given vehicle; (GII) nonoophorectomized mice treated with metoclopramide; (GIII) oophorectomized mice treated with metoclopramide; (GIV) oophorectomized mice treated with metoclopramide and 17beta-estradiol; (GV) oophorectomized mice treated with metoclopramide and micronized progesterone; (GVI) oophorectomized mice treated with metoclopramide and a solution of 17beta-estradiol and micronized progesterone...
March 15, 2010: Fertility and Sterility
Cecilia Bottomley, Tom Bourne
Nausea and vomiting occur in up to 80% of normal pregnancies. Hyperemesis gravidarum, resulting in dehydration and ketonuria, is a more severe, disabling and potentially life threatening condition affecting up to 1.5% of pregnancies. Treatment is supportive with intravenous rehydration, antiemetics and correction of vitamin deficiency to minimize complications. There are good safety data to support the use of antihistamines, phenothiazines and metoclopromide in hyperemesis gravidarum, though trials of efficacy are lacking and there is little evidence on which to chose the optimum therapy...
August 2009: Best Practice & Research. Clinical Obstetrics & Gynaecology
Fauzia Bano, Safia Zafar, Sadqa Aftab, Saeeda Haider
OBJECTIVE: To compare the efficacy of combination of dexamethasone plus ondansetron with dexamethasone alone for postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy. STUDY DESIGN: Double blinded randomized controlled clinical trial. PLACE AND DURATION OF STUDY: Department of Anaesthesiology, Surgical Intensive Care Unit and Pain Management, Dow University of Health Sciences and Civil Hospital, Karachi, from March 2007 to September 2007...
May 2008: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Vivek K Moitra, Steffen E Meiler
PURPOSE OF REVIEW: This review summarizes the current progress in disease classification, pathophysiology and management of diabetes mellitus with a special focus on treatment modalities and recommendations for the practicing anesthesiologist. RECENT FINDINGS: The revised classification of diabetes mellitus emphasizes disease cause and eliminates any reference to age-of-onset and insulin therapy. Hyperglycemia has emerged as an important marker of outcome in the operating room...
June 2006: Current Opinion in Anaesthesiology
Dipankar Mukherjee
The "open" repair of abdominal aortic aneurysm (AAA) continues to evolve with incorporation of less invasive methods for surgical exposure and the use of patient care pathways for shorter hospital stays. In a consecutive series of 30 patients with infrarenal AAA, a "fast-track" hospital care pathway was implemented that included the following: AAA exposure via a limited (10-15 cm) retroperitoneal incision, use of self-retaining retractor and special vascular clamps/instruments, and prosthetic graft endoaneurysmorrhaphy...
September 2003: Vascular and Endovascular Surgery
No abstract text is available yet for this article.
March 20, 1965: La Presse Médicale
Kalyani Maganti, Kingsley Onyemere, Michael P Jones
OBJECTIVE: Erythromycin is a motilin agonist that greatly increases the fractional rate of gastric emptying. Although a number of studies document the efficacy of erythromycin in improving gastric emptying, little information exists concerning symptom improvement in patients with gastroparesis. The aim of this study was to review clinical trials of erythromycin to determine the efficacy of this agent in producing symptom relief in patients with gastroparesis. METHODS: A MEDLINE search from 1966 to 2001 was performed to identify all clinical trials using erythromycin in patients with gastroparesis...
February 2003: American Journal of Gastroenterology
J Hardy, S Daly, B McQuade, M Albertsson, V Chimontsi-Kypriou, P Stathopoulos, P Curtis
Nausea and emesis are common side effects of opioid drugs administered for pain relief in cancer patients. The aim of this study was to compare the anti-emetic efficacy and safety of ondansetron, placebo and metoclopramide in the treatment of opioid-induced nausea and emesis (OIE) in cancer patients. This was a multinational, multicentre, double-blind, parallel group study in which cancer patients who were receiving a full opioid agonist for cancer pain were randomised to receive one of oral ondansetron 24 mg once daily, metoclopramide 10 mg three times daily, or placebo...
April 2002: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
E Y Eaker
Acute colonic pseudo-obstruction is characterized by distention of the colon in the absence of mechanical obstruction. This presentation is typically related to recent surgery, severe illness, or medication. Nasogastric and rectal tube decompression and correction of electrolyte abnormalities are the standard of care. Colonoscopic decompression, performed in a number of these cases, was felt to be unwarranted in many situations and is associated with a high recurrence rate. Medical management beyond conservative measures has been limited...
October 2001: Current Gastroenterology Reports
B A Moussa
Simple, sensitive and accurate spectrophotometric methods for the determination of glafenine and metoclopramide hydrochloride are described. The first method is based on the oxidation of glafenine with iodic acid in strong acid medium to give a coloured diphenylbenzidine derivative and subsequent measurement of the coloured product at 509 nm. Beer's law is obeyed over the concentration range 2.5-20 microg ml(-1). The second method depends on the interaction of metoclopramide hydrochloride with p-dimethylaminocinnamaldehyde, to give a red coloured schiffs base with an absorbance maximum at 548 nm...
November 2000: Journal of Pharmaceutical and Biomedical Analysis
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