Jia-Yue Duan, Rui-Xuan You, Yong Zhou, Feng Xu, Xiao Lin, Su-Kang Shan, Ming-Hui Zheng, Li-Min Lei, Fu-Xing-Zi Li, Bei Guo, Yun-Yun Wu, Xi Chen, Ke-Xin Tang, Ye-Chi Cao, Yan-Lin Wu, Si-Yang He, Rong Xiao, Ling-Qing Yuan
BACKGROUND: The relationship between socio-economic status and bone-related diseases is attracting increasing attention. Therefore, a bidirectional Mendelian randomization (MR) analysis was performed in this study. METHODS: Genetic data on factors associated with socio-economic status (average total household income before tax, years of schooling completed and Townsend Deprivation Index at recruitment), femoral neck bone mineral density (FN-BMD), heel bone mineral density (eBMD), osteoporosis, and five different sites of fracture (spine, femur, lower leg-ankle, foot, and wrist-hand fractures) were derived from genome-wide association summary statistics of European ancestry...
April 16, 2024: Journal of Bone and Mineral Research