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Ipratropium bromide

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https://www.readbyqxmd.com/read/27873181/inhalable-ipratropium-bromide-particle-engineering-with-multicriteria-optimization
#1
Bhavani Prasad Vinjamuri, Rahul V Haware, William C Stagner
Spray-dried ipratropium bromide (IPB) microspheres for oral inhalation were engineered using Quality by Design. The interrogation of material properties, process parameters, and critical product quality attributes interplay enabled rational product design. A 2(7-3) screening design exhibited the Maillard reaction between L-leucine (LL) and lactose at studied outlet temperatures (OT) >130°C. A response surface custom design was used in conjunction with multicriteria optimization to determine the operating design space to achieve inhalable microparticles...
November 21, 2016: AAPS PharmSciTech
https://www.readbyqxmd.com/read/27851485/1850-unilateral-pupillary-mydriasis-from-ipratropium-bromide-a-false-sign-of-stroke
#2
Anas Riehani, Rajit Pahwa
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27808011/bronchodilator-effects-of-ipratropium-bromide-and-albuterol-sulfate-among-subjects-with-tetraplegia
#3
Gregory J Schilero, Joshua C Hobson, Kamaldeep Singh, Ann M Spungen, William A Bauman, Miroslav Radulovic
OBJECTIVE: In addition to lung volume restriction, persons with chronic tetraplegia demonstrate obstructive airway physiology evinced by pharmacologically-induced bronchodilation. We previously found independent evidence that anticholinergic agents (ipratropium bromide; IB) and beta-2 adrenergic agonists (albuterol sulfate; AS) were associated with significant bronchodilation in subjects with tetraplegia as determined via spirometry or body plethysmography. Direct comparison of these two classes of agents has received little attention...
November 3, 2016: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/27787709/muscarinic-receptor-antagonists
#4
Maria Gabriella Matera, Mario Cazzola
Parasympathetic activity is increased in patients with chronic obstructive pulmonary disease (COPD) and asthma and appears to be the major reversible component of airway obstruction. Therefore, treatment with muscarinic receptor antagonists is an effective bronchodilator therapy in COPD and also in asthmatic patients. In recent years, the accumulating evidence that the cholinergic system controls not only contraction by airway smooth muscle but also the functions of inflammatory cells and airway epithelial cells has suggested that muscarinic receptor antagonists could exert other effects that may be of clinical relevance when we must treat a patient suffering from COPD or asthma...
October 28, 2016: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/27683661/-don-t-believe-your-eyes-ipratropium-induced-mydriasis-a-case-report-and-review-of-the-literature
#5
Kelly M Pennington, Erik K St Louis
Unilateral fixed mydriasis can be an ominous sign; however in many cases, it is benign and represents pharmacologic mediated action on the iris dilator or sphincter. Differentiation between pharmacologic mediated anisocoria and physiologic anisocoria can be challenging but may save on costly imaging. An 83 year-old woman was admitted with critical limb ischemia and subsequently developed respiratory failure treated with positive pressure ventilation and ipratropium nebulizers. She was noted to have left unilateral mydriasis without other neurologic deficits...
June 2016: General Medicine: Open Access
https://www.readbyqxmd.com/read/27525852/expression-of-m3-acetylcholine-receptor-in-asthmatic-mice-and-bronchial-airway-remodeling-prediction
#6
F Zhao, J Yang, P Chen, Y Wang, H Zhang, Q Zhang
This study aimed to investigate the role of M3 acetylcholine receptor (M3-AChR) expression in airway remodeling. Additionally, we aimed to evaluate the effects of ipratropium bromide solution inhaled in an early phase of asthma on airway remodeling in ovalbumin (OVA)-sensitized and challenged mice. Thirty BALB/c mice were divided into three groups, namely, control group (saline sensitized/challenged mice), asthma group (OVA sensitized/challenged mice), and treatment group (OVA sensitized/challenged mice treated by ipratropium bromide)...
2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27418820/efficacy-and-safety-of-ipratropium-bromide-salbutamol-sulphate-administered-in-a-hydrofluoroalkane-metered-dose-inhaler-for-the-treatment-of-copd
#7
Amal Bhattacharya, Salil Bhargava, Virendra Singh, Deepak Talwar, Jagdeep Whig, Juliet Rebello, Shrinivas Purandare, Jaideep Gogtay
BACKGROUND: The use of chlorofluorocarbons (CFCs) has contributed to the depletion of the stratospheric ozone layer resulting in serious health concerns. Ipratropium bromide/salbutamol sulphate CFC-pressurized metered-dose inhalers (IB/SAL-CFC pMDI) have been in widespread use for many years without any apparent ill consequences. This combination has now been reformulated using the hydrofluoroalkane (HFA) propellant. This study sought to establish the clinical noninferiority of a new HFA-containing IB/SAL pMDI to the conventional IB/SAL-CFC pMDI in subjects with mild/moderate COPD...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27359240/-asthma-bronchiale-emergency-medical-treatment
#8
Michael Hansen, Thomas Hachenberg
Treatment of patients with acute severe or life-threatening asthma in the emergency department or in rescue services is a challenge for the physician. The decision on which therapy is needed depends on the clinical assessment of severity. Early administration of bronchodilators, ipratropium bromide and oral or intravenous corticosteroids is the cornerstone of treatment. If these treatments fail, systemic administration of bronchodilators, MgSO4 and theophylline should be carried in order to avoid intubation...
June 2016: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/27303780/acute-viral-bronchiolitis-in-south-africa-strategies-for-management-and-prevention
#9
H J Zar, S A Madhi, D A White, R Masekela, S Risenga, H Lewis, C Feldman, B Morrow, P Jeena
Management of acute viral bronchiolitis is largely supportive. There is currently no proven effective therapy other than oxygen for hypoxic children. The evidence indicates that there is no routine benefit from inhaled, rapid short-acting bronchodilators, adrenaline or ipratropium bromide for children with acute viral bronchiolitis. Likewise, there is no demonstrated benefit from routine use of inhaled or oral corticosteroids, inhaled hypertonic saline nebulisation, montelukast or antibiotics. The last should be reserved for children with severe disease, when bacterial co-infection is suspected...
April 2016: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/27266281/-efficiency-of-nebulised-magnesium-sulphate-in-infective-exacerbations-of-chronic-obstructive-pulmonary-disease
#10
Şule Cömert, Esen Kıyan, Gülfer Okumuş, Orhan Arseven, Turhan Ece, Halim İşsever
INTRODUCTION: Conflicting results has been achieved in a small number of clinical studies evaluating the efficiency of magnesium sulphate (MS) in COPD exacerbations. We aimed to investigate the efficiency of nebulised MS in COPD exacerbations. PATIENTS AND METHODS: Twenty patients who met the study criteria were randomized into two groups. All patients were treated with O2, antibiotics and oral corticosteroids. Additionally one group received ipratropium bromide (IB) 500 µg together with MS 151 mg/dose, while the other group received IB together with placebo...
December 0: Tüberküloz Ve Toraks
https://www.readbyqxmd.com/read/27174172/novel-relaxant-effects-of-rpl554-on-guinea-pig-tracheal-smooth-muscle-contractility
#11
R Venkatasamy, D Spina
BACKGROUND AND PURPOSE: We investigated the effectiveness of RPL554, a dual PDE3 and 4 enzyme inhibitor, on airway smooth muscle relaxation and compared it with that induced by salbutamol, ipratropium bromide, glycopyrrolate or their combination on bronchomotor tone induced by different spasmogenic agents. EXPERIMENTAL APPROACH: Guinea pig tracheal preparations were suspended under 1 g tension in Krebs-Henseleit solution maintained at 37°C and aerated with 95% O2 /5% CO2 and incubated in the presence of indomethacin (5 μM)...
August 2016: British Journal of Pharmacology
https://www.readbyqxmd.com/read/27140677/bronchodilator-responsiveness-of-peripheral-airways-in-smokers-with-normal-spirometry
#12
Kanika Jetmalani, David G Chapman, Cindy Thamrin, Claude S Farah, Norbert Berend, Cheryl M Salome, Gregory G King
BACKGROUND AND OBJECTIVE: Cigarette smoke exposure increases airway smooth muscle (ASM) contractility. Abnormalities in peripheral airway function in smokers with normal spirometry could be due to the effects of ASM tone. We aimed to determine the contribution of ASM tone to peripheral airway function in smokers with normal spirometry from the response to bronchodilator (BD). METHODS: Ventilation heterogeneity in peripheral conductive (Scond) and acinar (Sacin) airways were measured in 50 asymptomatic smokers and 20 never-smokers using multiple breath nitrogen washout, before and 20 min after inhalation of 200 µg salbutamol and 80 µg ipratropium bromide...
October 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/27130202/efficacy-and-safety-of-ipratropium-bromide-albuterol-compared-with-albuterol-in-patients-with-moderate-to-severe-asthma-a-randomized-controlled-trial
#13
James F Donohue, Robert Wise, William W Busse, Sandra Garfinkel, Valentina B Zubek, Mo Ghafouri, Raymond C Manuel, Rozsa Schlenker-Herceg, Eugene R Bleecker
BACKGROUND: Many patients with asthma require frequent rescue medication for acute symptoms despite appropriate controller therapies. Thus, determining the most effective relief regimen is important in the management of more severe asthma. This study's objective was to evaluate whether ipratropium bromide/albuterol metered-dose inhaler (CVT-MDI) provides more effective acute relief of bronchospasm in moderate-to-severe asthma than albuterol hydrofluoroalkaline (ALB-HFA) alone after 4 weeks...
2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27061296/gnaphaliin-a-and-gnaphaliin-b-synergize-the-relaxant-effect-of-salbutamol-but-not-of-ipratropium-in-guinea-pig-trachea
#14
Fernando Rodríguez-Ramos, Miguel Ángel Andrade-Moreno, Alejandro Alfaro-Romero, José Luis Balderas-López, Andrés Navarrete
OBJECTIVE: This work was aimed to investigate the pharmacodynamic interactions between gnaphaliins A and B with ipratropium bromide (IBR) and salbutamol (SAL) using the guinea pig trachea model through application of the combination index (CI)-isobologram equation. METHODS: The guinea pig trachea rings in isolated chamber with Krebs-Henseleit solution (37°C) were contracted with carbachol (3 μm), and then, concentration-relaxant effect curves were constructed for individual drugs and in combination at fixed constant ratios (1 : 1, 3 : 1 and 1 : 3)...
April 2016: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/27006348/oronasal-and-tracheostomy-delivery-of-soft-mist-and-pressurized-metered-dose-inhalers-with-valved-holding-chamber
#15
Ariel Berlinski, Brandy Cooper
BACKGROUND: Some pediatric tracheostomized patients who receive inhaled drugs undergo decannulation, and it is unknown whether the dose has to be adjusted. Pressurized metered-dose inhalers (pMDIs) and soft mist inhalers (SMIs) used with valved holding chambers (VHCs) made of non-electrostatic material are available. We hypothesized that using an SMI and changing the delivery route from tracheostomy to oronasal would increase lung dose. METHODS: Four units of a metallic VHC were studied with albuterol hydrofluoroalkane (pMDI) and albuterol/ipratropium bromide with an SMI using an anatomically correct in vitro model of a 5-y-old spontaneously breathing tracheostomized child...
July 2016: Respiratory Care
https://www.readbyqxmd.com/read/26968269/response-to-nebulized-salbutamol-versus-combination-with-ipratropium-bromide-in-children-with-acute-severe-asthma
#16
Bilquis Naeem Memon, Arit Parkash, Khalid Mahmood Ahmed Khan, Murtaza Ali Gowa, Chandra Bai
OBJECTIVE: To compare the efficacy of nebulised salbutamol alone and in combination with ipratropium bromide in acute severe asthma in children. METHODS: The randomised controlled trial was conducted at the National Institute of Child Health, Karachi, from October 2012 to March 2013, and comprised patients with acute severe asthma who were randomised into two equal groups. Group A patients received 3 doses of nebulised salbutamol alone (0.03 ml/kg/dose) at 15-minute intervals and Group B received 3 similar doses of salbutamol along with ipratropium (250 ug/dose)...
March 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/26945929/efficiency-of-ipratropium-bromide-and-albuterol-deposition-in-the-lung-delivered-via-a-soft-mist-inhaler-or-chlorofluorocarbon-metered-dose-inhaler
#17
T R MacGregor, R ZuWallack, V Rubano, M A Castles, H Dewberry, M Ghafouri, C C Wood
The propellant-free Combivent Respimat Soft Mist Inhaler (CVT-R) was developed to replace the chlorofluorocarbon-propelled Combivent metered-dose inhaler (CVT-MDI). This steady-state pharmacokinetic (PK) substudy evaluated drug lung-delivery efficiency, using data from two phase III safety and efficacy trials. PK parameters were obtained from well-controlled population PK analyses. Area under the plasma concentration-time curve (AUC), maximum observed plasma concentration (C(max)), and minimum observed plasma concentration (C(min)) showed systemic exposure to ipratropium bromide and albuterol delivered via the CVT-R was proportional to ex-mouthpiece delivered dose...
April 2016: Clinical and Translational Science
https://www.readbyqxmd.com/read/26784496/acp-journal-club-review-in-copd-tiotropium-improves-lung-function-and-reduces-adverse-events-compared-with-ipratropium-bromide
#18
COMMENT
Diego J Maselli, Jay I Peters
No abstract text is available yet for this article.
January 19, 2016: Annals of Internal Medicine
https://www.readbyqxmd.com/read/26664561/asthma-changes-at-a-pediatric-intensive-care-unit-after-10-years-observational-study
#19
Ayman A Al-Eyadhy, Mohamad-Hani Temsah, Ali A N Alhaboob, Abdulmalik K Aldubayan, Nasser A Almousa, Abdulrahman M Alsharidah, Mohammed I Alangari, Abdulrahman M Alshaya
OBJECTIVES: To describe the change in the management, and outcome of children with acute severe asthma (ASA) admitted to Pediatric Intensive Care Unit (PICU) at tertiary institute, as compared to previously published report in 2003. METHODS: This is a retrospective observational study. All consecutive pediatric ASA patients who were admitted to PICU during the study period were included. The data were extracted from PICU database and medical records. The Cohort in this study (2013 Cohort) was compared with the Cohort of ASA, which was published in 2003 from the same institution (2003 Cohort)...
October 2015: Annals of Thoracic Medicine
https://www.readbyqxmd.com/read/26440415/efficiency-of-a-new-mesh-type-nebulizer-ne-sm1-neplus-for-intrapulmonary-delivery-of-ipratropium-bromide-in-surgical-patients
#20
Yong-Hun Lee, Gu-Youn Kwon, Do-Yang Park, Ji-Yeon Bang, Dong-Min Jang, Soo-Han Lee, Eun-Kyung Lee, Byung-Moon Choi, Gyu-Jeong Noh
This study was aimed to evaluate the efficiency of a new mesh-type nebulizer for the intrapulmonary delivery of ipratropium bromide in surgical patients under mechanical ventilation. A total of 20 patients were randomly allocated to receive 0.5 mg ipratropium bromide using either a control (Pariboy SX, Pari, Co., Starnberg, Germany, n = 10) or test (NE-SM1 NEPLUS, KTMED INC., Seoul, Korea, n = 10) nebulizer during general anaesthesia. Ipratropium bromide was nebulized continuously for 20 min. in each group...
April 2016: Basic & Clinical Pharmacology & Toxicology
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