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JOURNAL ARTICLE
Krishna Kiran Eachempati, Apurve Parameswaran, Vikas K Yadav, Roshna Prem Kumar, Vinay Kishore Ponnala, Sunil Apsingi
CASE: A 47-year-old orthopaedic surgeon presented with acute volar left wrist pain. He performed over 250 robot-assisted knee arthroplasties each year. Color Doppler evaluation revealed bilateral persistent median arteries and bifid median nerves, with focal occlusive thrombosis of the left median artery. He was advised rest and oral aspirin. He could return to his professional activities after 1 month. He had no recurrence of symptoms at 1 year of follow-up. CONCLUSION: Orthopaedic surgeons use vibrating hand tools on a daily basis...
April 1, 2024: JBJS Case Connector
#2
JOURNAL ARTICLE
Ai Fujita, Kazuhiro Shirozu, Midoriko Higashi, Ken Yamaura
BACKGROUND: Given the advances in medicine, women with Fontan circulation are now reaching childbearing age. However, data on the mode of delivery and anesthetic management of these patients are limited. We report the cases of five pregnant women with Fontan circulation. CASE PRESENTATION: The mean age at delivery was 28 ± 3 years, and the mean gestational period was 34 weeks and 3 days. Anticoagulation therapy was switched from warfarin and aspirin to continuous intravenous heparin...
April 18, 2024: JA Clinical Reports
#3
JOURNAL ARTICLE
Justin E Vranic, Adam A Dmytriw, Inka K Berglar, Naif M Alotaibi, Nicole M Cancelliere, Christopher J Stapleton, James D Rabinov, Pablo Harker, Rajiv Gupta, Joshua D Bernstock, Matthew J Koch, Scott B Raymond, Justin R Mascitelli, T Tyler Patterson, Joshua Seinfeld, Andrew White, David Case, Christopher Roark, Chirag D Gandhi, Fawaz Al-Mufti, Jared Cooper, Charles Matouk, Nanthiya Sujijantarat, Diego A Devia, Maria I Ocampo-Navia, Daniel E Villamizar-Torres, Juan C Puentes, Mohamed M Salem, Ammad Baig, Kareem El Namaani, Anna Luisa Kühn, Bryan Pukenas, Brian T Jankowitz, Jan Karl Burkhardt, Adnan Siddiqui, Pascal Jabbour, Jasmeet Singh, Ajit S Puri, Robert W Regenhardt, Vitor Mendes Pereira, Aman B Patel
BACKGROUND AND OBJECTIVES: Dual antiplatelet therapy (DAPT) is necessary to minimize the risk of periprocedural thromboembolic complications associated with aneurysm embolization using pipeline embolization device (PED). We aimed to assess the impact of platelet function testing (PFT) on reducing periprocedural thromboembolic complications associated with PED flow diversion in patients receiving aspirin and clopidogrel. METHODS: Patients with unruptured intracranial aneurysms requiring PED flow diversion were identified from 13 centers for retrospective evaluation...
April 18, 2024: Neurosurgery
#4
JOURNAL ARTICLE
Kyung Jin Oh, Sang-Yun Lee
PURPOSE: Analyzing Kawasaki disease epidemiology during the SARS-CoV-2 pandemic in South Korea using 2012-2020 National Health Insurance Service data. METHODS: The incidence of Kawasaki disease for 2012-2020 was investigated to identify changes in incidence after the start of the pandemic. National Health Insurance Service data from the Republic of Korea were used. Kawasaki disease was defined based on the International Statistical Classification of Diseases and Related Health Problems, the Tenth Revision diagnostic code (M30...
2024: Frontiers in Pediatrics
#5
JOURNAL ARTICLE
Helmut Mair, Stephanie Ulrich, Dow Rosenzweig, Johannes Goeppl, Christopher Jurma, Ferdinand Vogt, Benedikt Baumer, Frank Vogel, Peter Lamm
BACKGROUND: Patients requiring coronary artery bypass grafting (CABG) are often loaded with antithrombotic drugs (AT) and are at an increased risk for perioperative bleeding complications. Active AT removal by a hemoadsorption cartridge integrated in the cardiopulmonary bypass circuit is increasingly used in this setting to reduce bleeding, and herein we describe the extension of this application in patients on AT undergoing off-pump coronary artery bypass (OPCAB). METHODS: Ten patients (80% male; mean age: 67...
April 18, 2024: Journal of Cardiothoracic Surgery
#6
JOURNAL ARTICLE
Jiao Liu, Lixia Shen, Long Nguyen-Hoang, Qiongjie Zhou, Chi Chiu Wang, Xiaohong Lu, Daljit Sahota, Ka Chun Chong, Hao Ying, Weirong Gu, Rong Zhou, Huixia Yang, Yanmin Jiang, Dunjin Chen, Xiaotian Li, Liona Poon
INTRODUCTION: Pre-eclampsia (PE) affects about 5% of Chinese pregnant women and is a major cause of maternal and perinatal morbidity and mortality. The first trimester screening model developed by the Fetal Medicine Foundation, which uses the Bayes theorem to combine maternal characteristics and medical history together with measurements of biomarkers, has been proven to be effective and has superior screening performance to that of the traditional risk factor-based approach for the prediction of PE...
April 17, 2024: BMJ Open
#7
JOURNAL ARTICLE
Yi Li, Jing Li, Bin Wang, Quanmin Jing, Yujie Zeng, Aijie Hou, Zhifang Wang, Aijun Liu, Jinliang Zhang, Yaojun Zhang, Ping Zhang, Daming Jiang, Bin Liu, Jiamao Fan, Jun Zhang, Li Li, Guohai Su, Ming Yang, Weihong Jiang, Peng Qu, Hesong Zeng, Lu Li, Miaohan Qiu, Leisheng Ru, Shaoliang Chen, Yujie Zhou, Shubin Qiao, Gregg W Stone, Dominick J Angiolillo, Yaling Han
IMPORTANCE: Purinergic receptor P2Y12 (P2Y12) inhibitor monotherapy after a certain period of dual antiplatelet therapy (DAPT) may be an attractive option of maintenance antiplatelet treatment for patients undergoing percutaneous coronary intervention (PCI) who are at both high bleeding and ischemic risk (birisk). OBJECTIVE: To determine if extended P2Y12 inhibitor monotherapy with clopidogrel is superior to ongoing DAPT with aspirin and clopidogrel after 9 to 12 months of DAPT after PCI in birisk patients with acute coronary syndromes (ACS)...
April 17, 2024: JAMA Cardiology
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JOURNAL ARTICLE
Shanea M P Gibson, Tiffany A Hunter, Phillip E Charles, Melonie A C Morgan, Shari K R Griffith-Anderson, J Kennedy Cruickshank, Maxine D Gossell-Williams, Nadine A Johnson
OBJECTIVES: Sickle cell disease (SCD) occurs in 2.8 % of our Jamaican antenatal population with homozygous HbSS being most associated with adverse maternal and perinatal outcomes. METHODS: A retrospective comparative analysis of HbSS, HbSC and HbSβThal pregnancy outcomes at the University Hospital of the West Indies (UHWI) between January 2012 and December 2022 was conducted. RESULTS: Of 120 patients (138 pregnancies), obesity occurred in 36 % (20/56) of the 'non-HbSS' group, i...
April 18, 2024: Journal of Perinatal Medicine
#9
JOURNAL ARTICLE
Chloe A Mutimer, Bruce C V Campbell
No abstract text is available yet for this article.
April 17, 2024: Stroke; a Journal of Cerebral Circulation
#10
JOURNAL ARTICLE
Parvaneh Darabi, Safoora Gharibzadeh, Davood Khalili, Mehrdad Bagherpour-Kalo, Leila Janani
BACKGROUND & AIM: Cardiovascular disease (CVD) is the most important cause of death in the world and has a potential impact on health care costs, this study aimed to evaluate the performance of machine learning survival models and determine the optimum model for predicting CVD-related mortality. METHOD: In this study, the research population was all participants in Tehran Lipid and Glucose Study (TLGS) aged over 30 years. We used the Gradient Boosting model (GBM), Support Vector Machine (SVM), Super Learner (SL), and Cox proportional hazard (Cox-PH) models to predict the CVD-related mortality using 26 features...
April 16, 2024: BMC Medical Informatics and Decision Making
#11
JOURNAL ARTICLE
Rui Hua, Mingxi Li, Qingxia Lin, Mengying Dong, Xiaoxuan Gong, Zhenyu Lin, Yule Li, Chen Li, Tian Wu, Chunyue Tan, Wenhao Zhang, Qin Wang, Tianyu Wu, Xiaoyu Zhou, Fang Yang, Chunjian Li
Thrombolytic therapy is one of the most effective treatments for thrombus dissolution and recanalization of blocked vessels in thrombotic diseases. However, the application of the thrombolytic strategy has been limited due to unsatisfactory thrombolytic efficacy, relatively higher bleeding complications, and consequently restricted indications. Recombinant staphylokinase (r-SAK) is a third-generation thrombolytic agent produced by genetic engineering technology, which exhibits a better thrombolytic efficacy than urokinase and recombinant streptokinase...
April 16, 2024: ACS Applied Materials & Interfaces
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JOURNAL ARTICLE
(no author information available yet)
BACKGROUND: This study compares aspirin to enoxaparin for symptomatic VTE prophylaxis within 90 days of any type of hip or knee arthroplasty performed for any diagnosis, in patients enrolled in the CRISTAL trial. MATERIALS AND METHODS: CRISTAL was a cluster-randomised crossover, registry-nested non-inferiority trial across 31 hospitals in Australia. The primary publication was restricted to patients undergoing primary total hip or knee arthroplasty for a diagnosis of osteoarthritis...
2024: PloS One
#13
REVIEW
Alessandro Spirito, Sriya L Krishnan, Davide Capodanno, Dominick J Angiolillo, Roxana Mehran
Dual antiplatelet therapy-the combination of aspirin and a P2Y12 inhibitor-remains the standard antiplatelet regimen recommended to prevent ischemic complications immediately after percutaneous coronary intervention. Nonetheless, recent advances in stent technologies, percutaneous coronary intervention techniques, adjunctive pharmacotherapy for secondary prevention, and the rising awareness of the prognostic impact of bleeding, which are inevitably associated with dual antiplatelet therapy, led to the investigation of alternative antiplatelet regimens related to fewer bleeding and a preserved ischemic protection...
April 2024: Circulation. Cardiovascular Interventions
#14
EDITORIAL
Matthew T Brown, Nanette K Wenger
No abstract text is available yet for this article.
April 15, 2024: Current Cardiology Reviews
#15
JOURNAL ARTICLE
Bryce E Haac, Nathan N O'Hara, Elliott R Haut, Theodore T Manson, Gerard P Slobogean, Robert V O'Toole, Deborah M Stein
OBJECTIVES: To determine venous thromboembolism (VTE) testing patterns in an orthopaedic trauma population and to evaluate for differences in VTE surveillance by prophylaxis regimen through a secondary analysis of the ADAPT trial. DESIGN: Prospective randomized trial. SETTING: Level I trauma center. PATIENTS: Three hundred twenty-nine adult (18 years and older) trauma patients presenting with an operative extremity fracture proximal to the metatarsals/carpals or any pelvic or acetabular fracture requiring VTE prophylaxis...
June 2024: OTA international: the open access journal of orthopaedic trauma
#16
Kunal Bhugaonkar, Kshitij Balwaik, Neha Masne
Birth-associated structural issues with the heart are known as congenital heart disorders or defects. They might alter the heart's regular blood flow. A 10-month-old female child presented to a tertiary care hospital with symptoms of recurrent cyanotic spells with episodes of desaturation a few months after birth. ECG findings depicted a normal sinus rhythm with a right axis deviation along the right ventricular forces. Two-dimensional echocardiography showed a tetralogy of Fallot with pulmonary atresia with a patent ductus arteriosus from the undersurface of the arch with confluent small pulmonary arteries...
March 2024: Curēus
#17
JOURNAL ARTICLE
Zhi Chen, Dan-Dan DU, Ya Gao, Jun-Miao Chen, Cui-Ping Wei, Xiao-Gang Weng, Jian Sun, Xin-Yuan Wang, Zhi-Guo Wang, Mei-Yu Zhang
This study aims to explore the effects of tetramethylpyrazine(TMP) on pharmacokinetics in plasma and brain dialysate and neuropathic pain in the rat model of partial sciatic nerve injury(SNI), and to investigate the correlation between the analgesic effect of TMP and its concentrations in the plasma and brain dialysate. Male SD rats were randomized into Sham, SNI, and SNI+TMP groups. Mechanical stimulation with von frey filaments and cold spray method were employed to evaluate the mechanical sensitivity and cold sensitivity of rats...
March 2024: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
#18
JOURNAL ARTICLE
Aung Y Oo, Mahmoud Loubani, Marc W Gerdisch, Joseph Zacharias, Geoffrey M Tsang, Michael J Perchinsky, Robert Carl Hagberg, Mark Joseph, Mohanakrishnan Sathyamoorthy
OBJECTIVES: To assess if warfarin targeted to INR 1.8 (range 1.5-2.0) is safe for all patients with an On-X aortic mechanical valve. METHODS: This prospective, observational registry follows patients receiving warfarin targeted at an INR of 1.8 (range 1.5-2.0) plus daily aspirin (75-100 mg) after On-X aortic valve replacement. The primary end-point is a composite of thromboembolism, valve thrombosis, and major bleeding. Secondary end-points include the individual rates of thromboembolism, valve thrombosis, and major bleeding, as well as the composite in subgroups of home or clinic-monitored INR and risk categorization for thromboembolism...
April 15, 2024: European Journal of Cardio-thoracic Surgery
#19
JOURNAL ARTICLE
Ana Navas-Acien, Regina M Santella, Bonnie R Joubert, Zhen Huang, Yuliya Lokhnygina, Francisco Ujueta, Irina Gurvich, Nancy J LoIacono, Filippo Ravalli, Cynthia D Ward, Jeffery M Jarrett, Alfonsina De Leon Salazar, Robin Boineau, Teresa L Z Jones, Daniel B Mark, Jonathan D Newman, David M Nathan, Kevin J Anstrom, Gervasio A Lamas
BACKGROUND: The reduction in cardiovascular disease (CVD) events with edetate disodium (EDTA) in the Trial to Assess Chelation Therapy (TACT) suggested that chelation of toxic metals might provide novel opportunities to reduce CVD in patients with diabetes. Lead and cadmium are vasculotoxic metals chelated by EDTA. We present baseline characteristics for participants in TACT2, a randomized, double-masked, placebo-controlled trial designed as a replication of the TACT trial limited to patients with diabetes...
April 13, 2024: American Heart Journal
#20
JOURNAL ARTICLE
Sufeng Zhou, Tangping Zhao, Jie Wang, Luming Wang, Zimo Zhang, Jinying Zhu, Yuqing Zhao, Ying Zhu, Hao Sun, Feng Shao
Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most frequently used drugs that can cause liver toxicity. The aim of this study was to integrate bioanalytical and population pharmacokinetic (PopPK) assay to rapidly screen and quantify the concentrations of NSAIDs in plasma and monitor clinical safety. A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for the simultaneous quantification of acetaminophen (APAP), flurbiprofen (FLB), aspirin (ASP), and ibuprofen (IBP), four commonly used NSAIDs...
April 15, 2024: Biomedical Chromatography: BMC
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