keyword
https://read.qxmd.com/read/38511527/objective-evidence-that-nerve-decompression-surgery-reduces-neuropathic-dfu-recurrence-risk-to-less-than-5
#21
JOURNAL ARTICLE
Scott Nickerson, Dwayne S Yamasaki
SCOPE AND SIGNIFICANCE Care for the diabetic foot ulcer (DFU) continues to be a frustrating challenge. Standard of care (SOC) methods are plagued by regrettable levels of delayed healing, failures to heal, recurrence risk, and association with amputations and early mortality.1 We hope to bring attention to the clinical reports observing that diabetes is frequently accompanied by nerve trunk enlargement. Local sites of compression can then occur that cause neural dysfunction and pain, but respond to surgical nerve decompression (ND) and recover a degree of normal function...
March 21, 2024: Advances in Wound Care
https://read.qxmd.com/read/38510515/plantar-kinetics-during-wheeled-knee-walker-use-compared-to-different-assistive-walking-devices-in-persons-with-type-2-diabetes-mellitus
#22
JOURNAL ARTICLE
Holton C Gwaltney, Joseph W Harrington, Jose G Anguiano-Hernandez, David C Kingston
BACKGROUND: Diabetic patients with foot ulcers are commonly prescribed assistive walking devices to unload the affected foot and promote tissue healing. However, the effect on shear loads to the contralateral foot is unknown. This study investigated the effect of a wheeled knee walker (WKW), compared to common devices, on compressive and shear plantar forces carried by the propulsive foot during walking in patients with type 2 diabetes mellitus. A secondary objective investigated plantar forces' correlations with body weight unloaded (BWU)...
January 2024: Foot & ankle orthopaedics
https://read.qxmd.com/read/38510374/lactobacillus-plantarum-promotes-wound-healing-by-inhibiting-the-nlrp3-inflammasome-and-pyroptosis-activation-in-diabetic-foot-wounds
#23
JOURNAL ARTICLE
Xiaojun Wang, Xu Li, Jianjun Liu, Yue Tao, Tao Wang, Limeng Li
OBJECTIVE: Diabetic foot ulcer (DFU) impairs the quality of life of diabetic patients and overburdens healthcare systems and society. It is crucial to comprehend the pathophysiology of DFU and develop effective treatment strategies. The aim of this study was to to evaluate the therapeutic potential of Lactobacillus Plantarum (LP) on wound healing in DFU and to explore the underlying mechanisms. METHODS: To investigate the effects of LP on wound healing, human umbilical vein endothelial cells (HUVECs) were treated with advanced glycation end products (AGEs) and used to assess cell viability, migration, and pyroptosis using CCK-8, cell scratch, and flow cytometry...
2024: Journal of Inflammation Research
https://read.qxmd.com/read/38510326/dermal-regeneration-template-in-the-management-and-reconstruction-of-burn-injuries-and-complex-wounds-a-review
#24
JOURNAL ARTICLE
Subhas Gupta, Naiem Moiemen, John P Fischer, Christopher Attinger, Marc G Jeschke, Philippe Taupin, Dennis P Orgill
BACKGROUND: Dermal scaffolds have created a paradigm shift for burn and wound management by providing improved healing and less scarring, while improving cosmesis and functionality. Dermal regeneration template (DRT) is a bilayer membrane for dermal regeneration developed by Yannas and Burke in the 1980s. The aim of this review is to summarize clinical evidence for dermal scaffolds focusing on DRT for the management and reconstruction of burn injuries and complex wounds. METHODS: A comprehensive search of PubMed was performed from the start of indexing through November 2022...
March 2024: Plastic and Reconstructive Surgery. Global Open
https://read.qxmd.com/read/38509442/podcast-on-how-to-classify-foot-ulcers-in-people-with-diabetes-2023-update-of-the-iwgdf-guidelines-on-classification
#25
JOURNAL ARTICLE
Matilde Monteiro-Soares, Fran Game
INTRODUCTION: In this podcast, we present the result of the 2023 scheduled update of the 2019 guidelines of the International Working Group of the Diabetic Foot (IWGDF) addressing the use of systems to classify foot ulcers in people with diabetes in routine clinical practice. METHODS: These guidelines were based on a systematic review of the available literature that identified 28 classifications addressed in 149 articles and, subsequently, expert opinion using the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) methodology...
March 21, 2024: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://read.qxmd.com/read/38508732/-hereditary-sensory-and-autonomic-neuropathy-1e-showing-hyperreflexia-a-case-report
#26
JOURNAL ARTICLE
Hitoshi Hayashida, Yukimasa Arita, Kishin Koh, Yoshihisa Takiyama, Koji Ikezoe
A 52-year-old man had developed hearing loss since childhood, as well as recurrent foot ulcers and osteomyelitis since his forties. He presented with gait disturbance and dysarthria that had worsened over four years and a month, respectively. Neurological exams revealed cognitive impairment, proximal weakness of the lower extremities, generalized hyperrflexia, ataxia, sensory disturbances predominant in deep sensation, urinary retention, and gait instability. On nerve conduction study, no sensory nerve action potentials were evoked in the upper and lower limbs...
March 20, 2024: Rinshō Shinkeigaku, Clinical Neurology
https://read.qxmd.com/read/38508037/short-term-glucose-variability-as-a-determinant-of-the-healing-rate-of-diabetic-foot-ulcer-a-retrospective-study
#27
JOURNAL ARTICLE
Paola Caruso, Lorenzo Scappaticcio, Maurizio Gicchino, Filomena Castaldo, Mariluce Barrasso, Carla Carbone, Mariangela Caputo, Maria Tomasuolo, Vanda Amoresano Paglionico, Giuseppe Bellastella, Maria Ida Maiorino, Katherine Esposito
BACKGROUND: The aim of this study was to describe the clinical characteristics of people with diabetic foot ulcer (DFU) according to glucose variability (GV) and to investigate the relationship between GV and DFU outcome in a population with type 2 diabetes (T2D) and DFU. METHODS: This is a retrospective study of 300 individuals aged 64.3 years (181 males) treated for DFU in a tertiary-care center with a regular follow-up for 6 months. Laboratory measurements and clinical assessments were collected at baseline...
March 16, 2024: Diabetes & Metabolic Syndrome
https://read.qxmd.com/read/38507616/effectiveness-of-interventions-to-enhance-healing-of-chronic-foot-ulcers-in-diabetes-a-systematic-review
#28
JOURNAL ARTICLE
Pam Chen, Nalini Campillo Vilorio, Ketan Dhatariya, William Jeffcoate, Ralf Lobmann, Caroline McIntosh, Alberto Piaggesi, John Steinberg, Prash Vas, Vijay Viswanathan, Stephanie Wu, Fran Game
BACKGROUND: It is critical that interventions used to enhance the healing of chronic foot ulcers in diabetes are backed by high-quality evidence and cost-effectiveness. In previous years, the systematic review accompanying guidelines published by the International Working Group of the Diabetic Foot performed 4-yearly updates of previous searches, including trials of prospective, cross-sectional and case-control design. AIMS: Due to a need to re-evaluate older studies against newer standards of reporting and assessment of risk of bias, we performed a whole new search from conception, but limiting studies to randomised control trials only...
March 2024: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/38506582/wound-bed-preparation-2024-delphi-consensus-on-foot-ulcer-management-in-resource-limited-settings
#29
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
April 1, 2024: Advances in Skin & Wound Care
https://read.qxmd.com/read/38506581/risk-factors-and-frequency-of-foot-ulceration-in-patients-receiving-chronic-hemodialysis-treatment
#30
JOURNAL ARTICLE
Vacide Aşik Özdemir, Nesrin Nural
OBJECTIVE: To determine the prevalence and risk factors of foot ulceration in patients receiving hemodialysis treatment. METHODS: A total of 180 patients who received hemodialysis treatment in two state hospitals and a private health center between April 2017 and September 2017 were included in the study. The researchers collected data using a patient information form and by conducting physical evaluation of the lower extremities. They used the diabetic foot risk assessment algorithm to classify risk according to the data obtained...
April 1, 2024: Advances in Skin & Wound Care
https://read.qxmd.com/read/38504640/diabetic-foot-and-work-outcomes-a-review
#31
REVIEW
Theodoros Panou, Nikolaos Papanas, Evanthia Gouveri, Georgia Skoufi, Theodoros C Constantinidis, Evangelia Nena
The aim of this review article was to discuss impact of diabetic foot ulcers (DFUs) on employment status and work productivity. We performed a literature search from 2000 to 2023 in PubMed, Scopus, Google Scholar and in national repositories. The major work outcomes studied were presenteeism and absenteeism. Many DFUs patients had a poor social and educational background. Overall, DFUs patients experienced increased loss of productivity in their workplaces: either they had to be absent more working hours than average or they faced increased difficulty in meeting their daily requirements...
March 20, 2024: International Journal of Lower Extremity Wounds
https://read.qxmd.com/read/38504634/effectiveness-of-a-multidisciplinary-limb-preservation-program-in-reducing-regional-hospitalization-rates-for-patients-with-diabetes-related-foot-complications
#32
JOURNAL ARTICLE
Ali Manji, Reza Basiri, Francois Harton, Kenton Rommens, Karim Manji
OBJECTIVE: This study evaluated the toe and flow model (TFM), a limb preservation program led by podiatric surgeons in Alberta, Canada, for its impact on hospitalization rates and length of stay (LOS) in patients with diabetic foot complication (DFC). Diabetes, a leading cause of non-traumatic lower extremity amputations (LEAs) in Canada, often results in diabetic foot ulcers (DFUs), a major cause of infection, amputation, and hospitalization. TFM has reportedly reduced amputation rates by 39% to 56%...
March 20, 2024: International Journal of Lower Extremity Wounds
https://read.qxmd.com/read/38503690/extended-spectrum-beta-lactamase-escherichia-coli-diabetic-foot-osteomyelitis-causing-sausage-toe-deformity-successful-therapy-with-ertapenem-in-the-outpatient-setting
#33
JOURNAL ARTICLE
Georgios S Papaetis, Elena A Dionysiou, Ifigenia S Charalambous, Panagiotis T Doukanaris
BACKGROUND Diabetic foot osteomyelitis is a high-morbidity and debilitating complication of diabetic foot ulcers that contributes to significantly worse quality of life in the affected population and higher cost of healthcare services. One of the clinical presentations of diabetic foot osteomyelitis is the 'sausage' toe deformity, which affects the phalanges (local soft tissue infection and underlying bony changes). This deformity is highly suggestive of the presence of osteomyelitis. Unfortunately, during recent years, the emergence of antibiotic-resistant bacteria have created great difficulties in choosing appropriate empirical antibiotics for the treatment of diabetic foot infections...
March 8, 2024: American Journal of Case Reports
https://read.qxmd.com/read/38503249/the-effect-of-seven-step-educational-strategy-on-knowledge-of-diabetic-foot-ulcer-prevention-critical-thinking-and-self-efficacy-of-nursing-students-a-randomized-controlled-trial
#34
JOURNAL ARTICLE
Mehrad Nekouei, Fereshteh Javaheri Tehrani, Parvaneh Vasli, Malihe Nasiri
BACKGROUND: Diabetic foot ulcer is a significant complication of diabetes that carries a high mortality risk and is associated with substantial financial costs. Choosing a suitable educational model for nursing students as future nurses is necessary to improve knowledge and manage issues related to caring for diabetic patients. OBJECTIVES: To determine the effect of education based on the 7E learning cycle model on the knowledge of diabetic foot ulcer prevention, critical thinking, and self-efficacy in nursing students...
March 13, 2024: Nurse Education Today
https://read.qxmd.com/read/38502310/single-cell-analysis-of-age-related-changes-in-leukocytes-of-diabetic-mouse-hindpaws
#35
JOURNAL ARTICLE
James M Nichols, Hoang Vu Pham, Eric F Lee, Rajasekaran Mahalingam, Andrew J Shepherd
Complications associated with Type 1 and Type 2 diabetes, such as diabetic peripheral neuropathy and diabetic foot ulcers, are a growing health-care concern. In addition, this concern increases as diabetic patients age due to their increased susceptibility to complications. To address this growing problem, it is important to understand fluctuations in physiology which lead to pathological changes associated with the metabolic disturbances of diabetes. Our study explores dysregulation of immune cell populations in the hindpaws of healthy and diabetic mice at 12 and 21 weeks of age using single-cell RNA sequencing to provide insight into immune disruptions occurring in the distal limb during chronic diabetes...
March 19, 2024: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/38501724/polymethylmethacrylate-pmma-augmentation-enhances-the-mechanical-characteristics-of-midfoot-beam-constructs-in-charcot-neuroarthropathy-cadaver-model
#36
JOURNAL ARTICLE
Naveen Pattisapu, Dave T Huang, Giselle Porter, Rebisi Owhonda, Timothy Charlton, Christopher Gross, David Thordarson, Melodie F Metzger
BACKGROUND: Even with the best conservative care, patients with Charcot neuroarthropathy (CN) of the foot and ankle often ulcerate, increasing their risk of infection, amputation, and death. Surgical fixation has been associated with risk of recurrent ulceration, potentially due to poor bone quality prone to recurrent deformity and ulceration. We propose midfoot beam reconstruction with PMMA augmentation as a novel means of improving fixation. METHODS: A protocol was developed to create characteristic CN midfoot fragmentation both visually and fluoroscopically in each of 12 matched-pair cadaveric feet...
March 19, 2024: Foot & Ankle International
https://read.qxmd.com/read/38497521/second-metatarsal-length-and-transfer-ulcers-after-first-metatarsal-amputation-in-diabetic-foot-infections
#37
JOURNAL ARTICLE
Nicola A Cavalcanti, Katharina Martini, Tobias Götschi, Nicola Krähenbühl, Madlaina Schöni, Felix W A Waibel
BACKGROUND: Plantar transfer ulcers (TUs) underneath the second metatarsal head are frequent after first metatarsal ray amputations due to diabetic foot infections. Whether the second metatarsal length (2ML) is associated with TU occurrence in these patients is unclear. This study evaluated whether 2ML is associated with TU occurrence after first-ray amputations and whether ulcer-free survival is shorter in patients with "excess" 2ML. METHODS: Forty-two patients with a mean age of 67 (range 33-93) years, diabetes, and first metatarsal ray amputation (first amputation at the affected foot) were included...
March 18, 2024: Foot & Ankle International
https://read.qxmd.com/read/38496839/bibliometric-analysis-of-systematic-review-and-meta-analysis-on-diabetic-foot-ulcer
#38
JOURNAL ARTICLE
Yanyan Wang, Cong Wang, Lei Zheng
Many clinical management strategies have been proposed to deal with diabetic foot ulcers. However, the occurrence and recurrence of foot ulcers remain the major problems for diabetics. This study aims to identify, visualize, and characterize the meta-analyses on diabetic foot ulcer research. Articles published online were retrieved from the Web of Science core collection database using a search query incorporating MeSH terms and topics related to diabetic foot ulcers and meta-analysis. The publications were then analyzed for basic characteristics, including publication year, countries, topics covered, references, and keywords discussed in the articles...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38494793/the-effect-of-vegf-stimulation-in-diabetic-foot-ulcers-a-systematic-review
#39
REVIEW
Frederik S Bang, Veronica Leeberg, Ming Ding, Chris H Dreyer
Diabetic foot ulcers are a common and severe complication of diabetes mellitus, and a risk factor for amputation. Because of the vessel insufficiency in diabetic foot ulcers (DFU), vascular endothelial growth factor (VEGF) that simulates angiogenesis is of interest to promote wound healing. This systematic review evaluates the last 16 years of in-vivo studies with VEGF stimulation as a treatment for DFU, developed based on the last published systematic article. A total of 961 articles were identified through databases in two phases...
March 17, 2024: Wound Repair and Regeneration
https://read.qxmd.com/read/38489054/offloading-systems-for-the-treatment-of-neuropathic-foot-ulcers-in-patients-with-diabetes-mellitus-a-meta-analysis-of-randomized-controlled-trials-for-the-development-of-the-italian-guidelines-for-the-treatment-of-diabetic-foot-syndrome
#40
REVIEW
Carlotta Gauna, Francesco Romeo, Alessia Scatena, Cesare Miranda, Luigi Uccioli, Cristiana Vermigli, Antonio Volpe, Corrado Bordieri, Rodolfo Tramonta, Benedetta Ragghianti, Giulia Bandini, Matteo Monami, Luca Monge
AIM: To compare the effectiveness of commonly used offloading devices for the treatment of neuropathic foot ulcers in patients with diabetes mellitus. This meta-analysis (MA) has been performed for giving an answer to clinical questions on this topic of the Italian guideline on diabetic foot syndrome. METHODS: The present MA includes randomized controlled studies (duration > 12 weeks) comparing, in patients with diabetes mellitus and non-infected neuropathic foot ulcer: any offloading device vs either no offloading device or conventional footwear; removable versus non-removable offloading devices; surgical procedure vs other offloading approaches...
March 15, 2024: Acta Diabetologica
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