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https://www.readbyqxmd.com/read/29218841/improvement-of-conformal-arc-plans-by-using-deformable-margin-delineation-method-for-stereotactic-lung-radiotherapy
#1
Görkem Güngör, Melek Demir, Gökhan Aydın, Bülent Yapıcı, Banu Atalar, Enis Özyar
PURPOSE: Stereotactic body radiotherapy (SBRT) is an established treatment technique in the management of medically inoperable early stage non-small cell lung cancer (NSCLC). Different techniques such as volumetric modulated arc (VMAT) and three-dimensional conformal arc (DCA) can be used in SBRT. Previously, it has been shown that VMAT is superior to DCA technique in terms of plan evaluation parameters. However, DCA technique has several advantages such as ease of use and considerable shortening of the treatment time...
December 7, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29215765/helicobacter-pylori-induces-cdx2-and-cox2-expression-by-modulating-micrornas-in-esophageal-epithelial-cells
#2
Guigen Teng, Yun Dai, Yunxiang Chu, Jing Li, Hongchen Zhang, Ting Wu, Xiaowei Shuai, Weihong Wang
Dysregulation of microRNAs (miRNAs) has been linked to virulence factors of Helicobacter pylori (H. pylori). The role of H. pylori in esophageal disease has not been clearly defined. We previously reported that H. pylori-esophageal colonization promotes the incidence of Barrett's esophagus and esophageal adenocarcinoma in vivo. Here, we studied the direct effects of H. pylori on the transformation of esophageal epithelial cells, with particular focus on whether H. pylori exerts its effects by modulating miRNAs and their downstream target genes...
December 7, 2017: Cancer Science
https://www.readbyqxmd.com/read/29215325/dosikit-a-new-portable-immunoassay-for-fast-external-irradiation-biodosimetry
#3
Julie Bensimon Etzol, Marco Valente, Sandrine Altmeyer, Caroline Bettencourt, Samuel Bouvet, Guillaume Cosler, François Desangles, Michel Drouet, Fabrice Entine, Francis Hérodin, Flora Jourquin, Yannick Lecompte, Patrick Martigne, Xavier Michel, Jérôme Pateux, Nicolas Ugolin, Sylvie Chevillard
DosiKit is a new field-radiation biodosimetry immunoassay for rapid triage of individuals exposed to external total-body radiation. Here, we report on the validation of this immunoassay in human blood cell extracts 0.5 h after in vitro exposure to 137Cs gamma rays, using γ-H2AX analysis. First, calibration curves were established for five donors at doses ranging from 0 to 10 Gy and dose rates ranging from ∼0.8 to ∼3 Gy/min. The calibration curves, together with a γ-H2AX peptide scale, enabled the definition of inter-experimental correction factors...
December 7, 2017: Radiation Research
https://www.readbyqxmd.com/read/29196929/factors-associated-with-calcium-requirements-after-parathyroidectomy-in-chronic-kidney-disease-patients
#4
Yue Ding, Hongying Wang, Qiang Zou, Yiting Jin, Zijing Zhang, Junwen Huang
BACKGROUND: Renal hyperparathyroidism is a common complication of chronic kidney disease (CKD). Parathyroidectomy (PTX) for these patients continues to be a valuable option in the era of calcimimetics. Postoperative hypocalcemia is common after surgery. The aim of this study was to identify clinical factors to define postoperative calcium requirements. METHODS: From February 2013 to May 2017, 68 patients with chronic kidney disease 5 (CKD5) who underwent PTX were reviewed...
December 1, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/29183120/spectroscopic-investigation-of-the-primary-reaction-intermediates-in-the-oxidation-of-levitated-droplets-of-energetic-ionic-liquids
#5
Stephen James Brotton, Michael Lucas, Steven D Chambreau, Ghanshyam L Vaghjiani, Jiang Yu, Scott L Anderson, Ralf I Kaiser
The production of the next generation of hypergolic, ionic-liquid based fuels requires an understanding of the reaction mechanisms between the ionic liquid and oxidizer. We probed reactions between a levitated droplet of 1-methyl-4-amino-1,2,4-triazolium dicyanamide ([MAT][DCA]), with and without hydrogen-capped boron nanoparticles, and the nitrogen dioxide (NO2) oxidizer. The apparatus exploits an ultrasonic levitator enclosed within a pressure-compatible process chamber equipped with complimentary Raman, UV-visible, and Fourier transform infrared (FTIR) spectroscopic probes...
November 28, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29181155/comparison-of-the-effect-of-the-aerobic-glycolysis-inhibitor-dichloroacetate-and-of-the-krebs-cycle-inhibitor-lw6-on-cellular-and-humoral-alloimmunity
#6
Theodoros Eleftheriadis, Georgios Pissas, Athanasios Mavropoulos, Vassilios Liakopoulos, Ioannis Stefanidis
Cell metabolism is altered during T-cell and B-cell activation and differentiation. Clarifying the exact metabolic shifts may lead to the development of new immunosuppressive medications. In this study, the effect of the aerobic glycolysis inhibitor dichloroacetate (DCA) and of the Krebs cycle enzyme malate dehydrogenase 2 (MDH2) inhibitor LW6 on T-cell alloimmune clonal expansion and on alloantibody production, was evaluated. T-cell clonal expansion was assessed in two-way mixed lymphocyte reaction (MLR). Humoral alloimmunity was evaluated by the alloantibody production in one-way MLR...
November 2017: Biomedical Reports
https://www.readbyqxmd.com/read/29173038/state-of-the-art-of-the-environmental-behaviour-and-removal-techniques-of-the-endocrine-disruptor-3-4-dichloroaniline
#7
Andrea Luca Tasca, Ashleigh Fletcher
In recent years, the presence of Endocrine Disrupting Chemicals (EDCs) in wastewater discharges from agricultural and industrial sources, [1] fresh- and estuarine-waters, as well as soils, has been reported in the literature. [2] Studies of adverse changes in wildlife, linked to environmental exposure to these substances, and the suggestion that humans could also be at similar risk of adverse health effects, [3-5] have raised concern for urgent action to understand and reduce such risks. 3,4-Dichloroaniline (3,4-DCA) has been recognized as an EDC, with regards to endocrine disruption data for both wildlife populations and human health...
November 27, 2017: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/29169632/effects-of-annular-contraction-on-anterior-leaflet-strain-using-an-in-vitro-simulator-with-a-dynamically-contracting-mitral-annulus
#8
Thomas F Easley, Charles H Bloodworth, Vinay Bhal, Ajit P Yoganathan
Using in vitro models, the mechanics as well as surgical techniques for mitral valves (MV) and MV devices can be studied in a more controlled environment with minimal monetary investment and risk. However, these current models rely on certain simplifications, one being that the MV has a static, rigid annulus. In order to study more complex issues of imaging diagnostics and implanted device function, it would be more advantageous to verify their use for a dynamic environment in a dynamic simulator. This study provides the novel design and development of a dynamically contracting annulus (DCA) within an in vitro simulator, and its subsequent use to study MV biomechanics...
November 20, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29165812/a-novel-and-validated-prognostic-nomogram-based-on-liver-fibrosis-and-tumor-burden-for-patients-with-hepatocellular-carcinoma-after-curative-resection
#9
Jin-Long Huang, Yi-Peng Fu, Chu-Yu Jing, Yong Yi, Jian Sun, Wei Gan, Zhu-Feng Lu, Jian Zhou, Jia Fan, Shuang-Jian Qiu
BACKGROUND AND OBJECTIVES: Most conventional staging systems were formulated concerning the tumor burden rather than the severity of liver fibrosis, which plays a central role in tumor promotion. The aim of this study was to formulate a prognostic nomogram comprehensively considering these two aspects for HCC after hepatectomy. METHODS: The prognostic significances of the four indicators namely laminin, hyaluronic acid, human procollagen type-III, and collagen type-IV that reflect liver fibrosis were explored in two independent cohorts...
November 22, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29163214/predictive-value-of-dynamic-cerebral-autoregulation-assessment-in-surgical-management-of-patients-with-high-grade-carotid-artery-stenosis
#10
Vladimir B Semenyutin, Gregory A Asaturyan, Anna A Nikiforova, Vugar A Aliev, Grigory K Panuntsev, Vadim B Iblyaminov, Alexander V Savello, Andreas Patzak
Dynamic cerebral autoregulation (DCA) capacity along with the degree of internal carotid artery (ICA) stenosis and characteristics of the plaque can also play an important role in selection of appropriate treatment strategy. This study aims to classify the patients with severe ICA stenosis according to preoperative state of DCA and to assess its dynamics after surgery. Thirty-five patients with severe ICA stenosis having different clinical type of disease underwent reconstructive surgery. DCA was assessed with transfer function analysis (TFA) by calculating phase shift (PS) between Mayer waves of blood flow velocity (BFV) and blood pressure (BP) before and after operation...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29143921/dichloroacetate-induced-intracellular-acidification-in-glioblastoma-in-vivo-detection-using-aacid-cest-mri-at-9-4%C3%A2-tesla
#11
Mohammed Albatany, Alex Li, Susan Meakin, Robert Bartha
Intracellular pH (pHi) plays an important role in the maintenance of normal cell function, and is maintained within a narrow range by the activity of transporters located at the plasma membrane. Modulation of tumor pHi may influence proliferation, apoptosis, chemotherapy resistance, and thermosensitivity. Chemical exchange saturation transfer (CEST) is a novel MRI contrast mechanism that is dependent on cellular pH. Amine and amide concentration-independent detection (AACID) is a recently developed CEST contrast method that is intracellular pH (pHi) weighted...
November 16, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29134188/simulation-study-of-quantitative-precision-of-the-pet-x-dedicated-breast-pet-scanner
#12
Chengeng Zeng, Paul E Kinahan, Hua Qian, Robert L Harrison, Kyle M Champley, Lawrence R MacDonald
The goal for positron emission tomography (PET)/X is measuring changes in radiotracer uptake for early assessment of response to breast cancer therapy. Upper bounds for detecting such changes were investigated using simulation and two image reconstruction algorithms customized to the PET/X rectangular geometry. Analytical reconstruction was used to study spatial resolution, comparing results with the distance of the closest approach (DCA) resolution surrogate that is independent of the reconstruction method...
October 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/29129408/efficiency-of-decolorization-of-different-dyes-using-fungal-biomass-immobilized-on-different-solid-supports
#13
Wioletta Przyśtas, Ewa Zabłocka-Godlewska, Elżbieta Grabińska-Sota
Different technologies may be used for decolorization of wastewater containing dyes. Among them, biological processes are the most promising because they seem to be environmentally safe. The aim of this study was to determine the efficiency of decolorization of two dyes belonging to different classes (azo and triphenylmethane dyes) by immobilized biomass of strains of fungi (Pleurotus ostreatus - BWPH, Gleophyllum odoratum - DCa and Polyporus picipes - RWP17). Different solid supports were tested for biomass immobilization...
November 9, 2017: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/29124911/first-north-american-validation-and-head-to-head-comparison-of-four-preoperative-nomograms-for-prediction-of-lymph-node-invasion-before-radical-prostatectomy
#14
Marco Bandini, Michele Marchioni, Raisa S Pompe, Zhe Tian, Giorgio Gandaglia, Nicola Fossati, Firas Abdollah, Markus Graefen, Francesco Montorsi, Fred Saad, Shahrokh F Shariat, Alberto Briganti, Pierre I Karakiewicz
OBJECTIVES: To perform a head-to-head comparison of four nomograms, namely the Cagiannos, the 2012-Briganti, the Godoy and the online-Memorial Sloan Kettering Cancer Center (MSKCC), for prediction of lymph node invasion (LNI) in a North American population. MATERIALS & METHODS: 19,775 clinically localized prostate cancer (PCa) patients underwent radical prostatectomy and pelvic lymph node dissection (PLND) were identified within the Surveillance Epidemiology and End Results (SEER) database...
November 10, 2017: BJU International
https://www.readbyqxmd.com/read/29124862/catabolic-task-division-between-two-interchangeable-near-isogenic-subpopulations-co-existing-in-a-herbicide-degrading-bacterial-consortium-consequences-for-the-interspecies-consortium-metabolic-model
#15
Pieter Albers, Cédric Lood, Basak Özturk, Benjamin Horemans, Rob Lavigne, Vera van Noort, René De Mot, Kathleen Marchal, Aminael Sanchez-Rodriguez, Dirk Springael
Variovorax sp. WDL1 mediates hydrolysis of the herbicide linuron into 3,4-dichloroaniline (DCA) and N,O-dimethylhydroxylamine in a tripartite bacterial consortium with Comamonas testosteroni WDL7 and Hyphomicrobium sulfonivorans WDL6. Although strain WDL1 contains the dcaQTA1A2B operon for DCA oxidation, this conversion is mainly performed by WDL7. Phenotypic diversification observed in WDL1 cultures and scrutiny of the WDL1 genome suggest that WDL1 cultures consist of two dedicated subpopulations, i.e., a linuron-hydrolyzing subpopulation (Lin+DCA-) and a DCA-oxidizing subpopulation (Lin-DCA+)...
November 10, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/29122806/diagnostic-utility-of-appetite-loss-in-addition-to-existing-prediction-models-for-community-acquired-pneumonia-in-the-elderly-a-prospective-diagnostic-study-in-acute-care-hospitals-in-japan
#16
Toshihiko Takada, Yosuke Yamamoto, Kazuhiko Terada, Mitsuyasu Ohta, Wakako Mikami, Hajime Yokota, Michio Hayashi, Jun Miyashita, Teruhisa Azuma, Shingo Fukuma, Shunichi Fukuhara
OBJECTIVE: Diagnosis of community-acquired pneumonia (CAP) in the elderly is often delayed because of atypical presentation and non-specific symptoms, such as appetite loss, falls and disturbance in consciousness. The aim of this study was to investigate the external validity of existing prediction models and the added value of the non-specific symptoms for the diagnosis of CAP in elderly patients. DESIGN: Prospective cohort study. SETTING: General medicine departments of three teaching hospitals in Japan...
November 8, 2017: BMJ Open
https://www.readbyqxmd.com/read/29111514/a-new-two-dimensional-polymeric-cadmium-ii-complex-containing-dicyanamide-bridging-ligands
#17
Yang Lu, Wei Qiang Liao, Xiu Ni Hua
As part of an exploration of new coordination polymers, a cadmium-dicyanamide complex, namely poly[benzyltriethylammonium [tri-μ-dicyanamido-κ(6)N(1):N(5)-cadmium(II)]], {(C13H22N)[Cd(C2N3)3]}n, has been synthesized by the reaction of benzyltriethylammonium bromide, cadmium nitrate tetrahydrate and sodium dicyanamide in aqueous solution, and characterized by single-crystal X-ray diffraction at room temperature. In the crystal structure, each Cd(II) cation is coordinated by six nitrile N atoms from six anionic dicyanamide (dca) ligands to furnish a slightly distorted octahedral geometry...
November 1, 2017: Acta Crystallographica. Section C, Structural Chemistry
https://www.readbyqxmd.com/read/29111029/hematoma-volume-is-a-predictive-factor-of-disturbed-autoregulation-after-spontaneous-intracerebral-hemorrhage
#18
Hongyin Ma, Zhen-Ni Guo, Xin Sun, Jia Liu, Shan Lv, Lu Zhao, Weitong Guo, Hang Jin, Yi Yang
BACKGROUND: Dynamic cerebral autoregulation (dCA) is probably disturbed after spontaneous intracerebral hemorrhage (ICH) and could be an independent predictor of clinical outcome. Clinical determinants of dCA status after ICH need to be further elucidated. METHODS: We finally enrolled 53 patients diagnosed with supratentorial ICH within 6days from onset. DCA was assessed 4-6days after ICH onset by monitoring middle cerebral artery blood flow velocities and simultaneous arterial blood pressure continuously, utilizing transcranial Doppler combined with a servo-controlled finger plethysmograph...
November 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29094419/dynamic-collimator-trajectory-algorithm-for-multiple-metastases-dynamic-conformal-arc-treatment-planning
#19
R Lee MacDonald, Christopher G Thomas, Alasdair Syme
PURPOSE: To develop an algorithm for dynamic collimator positioning to optimize beam's-eye-view (BEV) fitting of targets in dynamic conformal arc (DCA) based radiotherapy procedures, of particular use in multiple metastases stereotactic radiosurgery procedures. METHODS: A trajectory algorithm was developed to dynamically modify the angle of the collimator as a function of arc-based control point to provide optimized collimation of target volume(s). Central to this algorithm is a concept denoted herein as "whitespace" defined as any non-target area in the BEV that is not covered by any collimation system and is open to exposure from the radiation beam...
November 1, 2017: Medical Physics
https://www.readbyqxmd.com/read/29094121/molecular-dynamics-simulations-of-pyrrolidinium-and-imidazolium-ionic-liquids-at-graphene-interfaces
#20
Srđan Begić, Erlendur Jónsson, Fangfang Chen, Maria Forsyth
Understanding the electrode-electrolyte interface is essential in the battery research as the ion transport and ion structures at the interface most likely affect the performance of a battery. Here we investigate interfacial structures of three ionic liquids: 1-ethyl-3-methylimidazolium dicyanamide ([C2mim][dca]), 1-butyl-3-methylimidazolium dicyanamide ([C4mim][dca]) and N-butyl-N-methylpyrrolidinium dicyanamide ([C4myr][dca]) at a charged and uncharged graphene interface using molecular dynamics simulations...
November 2, 2017: Physical Chemistry Chemical Physics: PCCP
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