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https://www.readbyqxmd.com/read/28102944/a-simple-and-robust-trajectory-based-stereotactic-radiosurgery-treatment
#1
Byron Wilson, Karl Otto, Ermias Gete
INTRODUCTION: We present a Trajectory-based Volumetric Modulated Arc Therapy (TVMAT) technique for Stereotactic Radiosurgery (SRS) that takes advantage of a modern linacs ability to modulate dose rate and move the couch dynamically. In addition, we investigate the quality of the developed TVMAT method and the dosimetric accuracy of the technique. METHODS: The main feature of the TVMAT technique is a standard beam trajectory formed by dynamic motion of the treatment couch and the linac gantry...
January 2017: Medical Physics
https://www.readbyqxmd.com/read/28090067/discovery-and-synthesis-of-amino-acids-modified-deoxycholic-acid-derivatives-and-in-vitro-antiproliferative-evaluation
#2
Chunhui Zhao, Peizhe Zhao, Bin Feng, Xiyan Hou, Longxuan Zhao
A series of deoxycholic acid (DCA) derivatives bearing amino acid moiety has been synthesized and investigated for their potential antiproliferative activities. DCA derivative compounds were synthesized by a two or three step synthetic approach. Their bioactivities were evaluated using MTT method and Western blotting analysis on three tumor cell lines A549, MCF-7 and HeLa. The novel derivatives DCA3d, DCA5a, DCA5b, DCA5c, and DCA5d were found to be promising antiproliferative agents. Furthermore, DCA5b showed the greatest cytotoxic activity by induction of apoptosis...
January 13, 2017: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28086795/atherosclerotic-and-thrombotic-genetic-and-environmental-determinants-in-egyptian-coronary-artery-disease-patients-a-pilot-study
#3
Manal S Fawzy, Eman A Toraih, Nagwa M Aly, Abeer Fakhr-Eldeen, Dahlia I Badran, Mohammad H Hussein
BACKGROUND: Coronary artery disease (CAD) is the leading cause of morbidity and mortality worldwide. Multiple genetic variants in combination with various environmental risk factors have been implicated. This study aimed to investigate the association of twelve thrombotic and atherosclerotic gene variants in combination with other environmental risk factors with CAD risk in a preliminary sample of Egyptian CAD patients. METHODS: Twenty three consecutive CAD patients undergoing diagnostic coronary angiography and 34 unrelated controls, have been enrolled in the study...
January 13, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28070271/heterogeneous-microcommunities-and-ecosystem-multifunctionality-in-seminatural-grasslands-under-three-management-modes
#4
Jingpeng Li, Zhirong Zheng, Hongtao Xie, Nianxi Zhao, Yubao Gao
Increasing attention has been paid to the relationship between biodiversity and ecosystem functioning (BEF) because of the rapid increase in species loss. However, over the past 20 years, most BEF studies only focused on the effect of species diversity on one or a few ecosystem functions, and only a few studies focused on ecosystem multifunctionality (i.e., the simultaneous provision of several ecosystem functions). Grassland ecosystems have important economic, environmental, and esthetic value; thus, this study focused on the heterogeneous microcommunities in grasslands under three management modes...
January 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28066138/potentiation-of-decursinol-angelate-on-pentobarbital-induced-sleeping-behaviors-via-the-activation-of-gabaa-ergic-systems-in-rodents
#5
Jae Hoon Woo, Tae-Woo Ha, Jae-Seon Kang, Jin Tae Hong, Ki-Wan Oh
Angelicae Gigantis Radix (AGR, Angelica gigas) has been used for a long time as a traditional folk medicine in Korea and oriental countries. Decursinol angelate (DCA) is structurally isomeric decursin, one of the major components of AGR. This study was performed to confirm whether DCA augments pentobarbital-induced sleeping behaviors via the activation of GABAA-ergic systems in animals. Oral administration of DCA (10, 25 and 50 mg/kg) markedly suppressed spontaneous locomotor activity. DCA also prolonged sleeping time, and decreased the sleep latency by pentobarbital (42 mg/kg), in a dose-dependent manner, similar to muscimol, both at the hypnotic (42 mg/kg) and sub-hypnotic (28 mg/kg) dosages...
January 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/28060903/a-comparison-of-a-machine-learning-model-with-euroscore-ii-in-predicting-mortality-after-elective-cardiac-surgery-a-decision-curve-analysis
#6
Jérôme Allyn, Nicolas Allou, Pascal Augustin, Ivan Philip, Olivier Martinet, Myriem Belghiti, Sophie Provenchere, Philippe Montravers, Cyril Ferdynus
BACKGROUND: The benefits of cardiac surgery are sometimes difficult to predict and the decision to operate on a given individual is complex. Machine Learning and Decision Curve Analysis (DCA) are recent methods developed to create and evaluate prediction models. METHODS AND FINDING: We conducted a retrospective cohort study using a prospective collected database from December 2005 to December 2012, from a cardiac surgical center at University Hospital. The different models of prediction of mortality in-hospital after elective cardiac surgery, including EuroSCORE II, a logistic regression model and a machine learning model, were compared by ROC and DCA...
2017: PloS One
https://www.readbyqxmd.com/read/28048536/su-f-t-510-single-isocenter-radiosurgery-for-the-simultaneous-treatment-of-multiple-brain-metastases-volumetric-modulated-arc-therapy-or-dynamic-conformal-arc
#7
J Maurer, B Sintay, M Manning, D Wiant, H Liu
PURPOSE: This study evaluates a novel algorithm that can be used with any treatment planning system for simple and rapid generation of stereotactic radiosurgery (SRS) plans for treating multiple brain metastases using a single isocenter dynamic conformal arc (DCA) approach. This technique is compared with a single isocenter volumetric modulated arc therapy (VMAT) technique in terms of delivery time, conformity, low dose spread and delivery accuracy. METHODS: Five patients, with a total of 37 (5 - 11) targets were planned using a previously published method for generating optimal VMAT plans and using the proposed DCA algorithm...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048465/su-f-t-591-sbrt-treatment-of-multiple-extracranial-oligometastases-using-a-single-isocenter-with-distinct-optimizations-sido
#8
M Trager, J Adamson, J Salama
PURPOSE: A new development in linac-based intracranial radiosurgery is treatment of multiple targets using single isocenter VMAT, which dramatically reduces treatment time while maintaining high conformality and dose gradient. Our purpose is to translate this technique to extracranial SBRT of oligometastases and address additional challenges such as interplay from motion and setup uncertainties. METHODS: We propose SIDO (Single Isocenter with Distinct Optimizations) planning in which all VMAT arcs share an isocenter but each arc treats only one target...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048385/su-g-brc-07-evaluation-of-aaa-focal-spot-size-for-srs-planning-using-end-to-end-dosimetric-data
#9
S Gardner, A Doemer, B Miller, N Wen, I Chetty
PURPOSE: To use end-to-end dosimetric measurements with Gafchromic film to evaluate the effects of focal spot size parameter for small-field dose calculations using AAA for SRS lesions. METHODS: A total of 13 plans, corresponding to 7 patients previously treated with cranial SRS, were analyzed in this study (target volume range:[0.67cc,13.9cc]). The plans included DCA delivery (4 plans total) and VMAT delivery (9 plans total). All plans were mapped to a solid water phantom (15 cm thickness; isocenter and film plane at 7...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047648/su-g-tep2-08-evaluation-of-plastic-scintillator-detector-for-small-field-stereotactic-patient-specific-quality-assurance
#10
Y Qin, S Gardner, Y Huang, J Kim, N Wen, I Chetty
PURPOSE: To evaluate the performance of a commercial plastic scintillator detector (PSD) for small-field stereotactic patient-specific quality assurance using flattening-filter-free (FFF) beams. METHODS: A total of ten spherical targets (volume range:[0.03cc-2cc]) were planned using Dynamic Conformal Arc(DCA-10 plans) and Volumetric Modulated Arc Therapy(VMAT-10 plans) techniques in Eclipse(AAA v.11, 1mm dose calculation grid size). Additionally, 15 previously-treated cranial and spine SRS plans were evaluated (6 DCA, 9 VMAT, volume range:[0...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047173/su-f-t-564-3-year-experience-of-treatment-plan-qualityassurance-for-vero-sbrt-patients
#11
Z Su, M Mamalui, Z Li
PURPOSE: To verify treatment plan monitor units from iPlan treatment planning system for Vero Stereotactic Body Radiotherapy (SBRT) treatment using both software-based and (homogeneous and heterogeneous) phantom-based approaches. METHODS: Dynamic conformal arcs (DCA) were used for SBRT treatment of oligometastasis patients using Vero linear accelerator. For each plan, Monte Carlo calculated treatment plans MU (prescribed dose to water with 1% variance) is verified first by RadCalc software with 3% difference threshold...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047051/su-f-t-589-hybridarc-planning-criteria-for-brain-srs
#12
K Jeong, A Basavatia, D Mynampati, M Garg, S Kalnicki, W Tome
PURPOSE: To compare VMAT SRS plans, dynamic conformal arc (DCA) plans, and Brainlab iPlan's capability of planning and delivering brain SRS plans by employing HybridArc. HybridArc utilizes both DCA and IMRT. Using HybridArc, the amount of DCA versus IMRT needs to be optimized. METHODS: Four SRS patients with the aim of reducing brainstem dose were selected for this study. All patients were contoured in iPlan and transferred to Eclipse for VMAT planning. In iPlan, DCA plans were created for each case...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046598/su-f-t-334-has-imrt-changed-the-impact-of-mlc-leaf-width-a-systematic-review-and-meta-analysis-of-tps-studies
#13
M Luzzara, L Santoro, K Brown
PURPOSE: We have performed a systematic review and meta-analysis in order to compare MLC leaf width used for different treatment techniques such as conformal and IMRT. METHODS: Medline and Google scholar databases have been searched using the "MLC leaf width" keywords with a cut-off date of 31st December 2015, considering only peer-reviewed papers. We have defined as intervention the MLC leaf width of 5 and 2.5 mm. We used the Conformity Index (CI) as the outcome subjected to the analysis...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046264/su-f-j-189-a-method-to-improve-the-spatial-resolution-of-prompt-gamma-based-compton-imaging-for-proton-range-verification
#14
E Draeger, D Mackin, S Peterson, H Chen, S Beddar, J Polf
PURPOSE: To test two new techniques, the distance-of-closest approach (DCA) and Compton line (CL) filters, developed as a means of improving the spatial resolution of Compton camera (CC) imaging. METHODS: Gammas emitted from (22) Na, (137) Cs, and (60) Co point sources were measured with a prototype 3-stage CC. The energy deposited and position of each interaction in each stage were recorded and used to calculate a "cone-of-origin" for each gamma that scattered twice in the CC...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28042671/monte-carlo-decision-curve-analysis-using-aggregate-data
#15
Iztok Hozo, Athanasios Tsalatsanis, Benjamin Djulbegovic
BACKGROUND: Decision curve analysis (DCA) is an increasingly used method for evaluating diagnostic tests and predictive models but its application requires individual patient data. The Monte Carlo (MC) method can be used to simulate probabilities and outcomes of individual patients and offers an attractive option for application of DCA. METHODS: We constructed a MC decision model to simulate individual probabilities of outcomes of interest. These probabilities were contrasted against the threshold probability at which a decision-maker is indifferent between key management strategies: treat all, treat none, or use predictive model to guide treatment...
January 2, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28041563/effect-of-dynamic-controlled-atmosphere-monitored-by-respiratory-quotient-and-1-methylcyclopropene-on-the-metabolism-and-quality-of-galaxy-apple-harvested-at-three-maturity-stages
#16
Fabio Rodrigo Thewes, Auri Brackmann, Rogerio de Oliveira Anese, Vagner Ludwig, Erani Eliseu Schultz, Luana Ferreira Dos Santos, Lucas Mallmann Wendt
The objective of this study was to evaluate the interaction between controlled atmosphere (CA), CA+1-methylcyclopropene (1-MCP) and dynamic controlled atmosphere monitored by respiratory quotient (DCA-RQ) with three fruit maturity stages at harvest (early harvest date, optimal harvest date and late harvest date) on 'Galaxy' apple metabolism and quality after harvest and 9months storage plus 7days of shelf life at 20°C. Fruit stored under dynamic controlled atmosphere monitored by respiratory quotient 1.3 (DCA-RQ 1...
May 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28040265/pyruvate-dehydrogenase-kinase-4-deficiency-attenuates-cisplatin-induced-acute-kidney-injury
#17
Chang Joo Oh, Chae-Myeong Ha, Young-Keun Choi, Sungmi Park, Mi Sun Choe, Nam Ho Jeoung, Yang Hoon Huh, Hyo-Jeong Kim, Hee-Seok Kweon, Ji-Min Lee, Sun Joo Lee, Jae-Han Jeon, Robert A Harris, Keun-Gyu Park, In-Kyu Lee
Clinical prescription of cisplatin, one of the most widely used chemotherapeutic agents, is limited by its side effects, particularly tubular injury-associated nephrotoxicity. Since details of the underlying mechanisms are not fully understood, we investigated the role of pyruvate dehydrogenase kinase (PDK) in cisplatin-induced acute kidney injury. Among the PDK isoforms, PDK4 mRNA and protein levels were markedly increased in the kidneys of mice treated with cisplatin, and c-Jun N-terminal kinase activation was involved in cisplatin-induced renal PDK4 expression...
December 28, 2016: Kidney International
https://www.readbyqxmd.com/read/28035595/effects-of-diet-type-developmental-stage-and-gut-compartment-in-the-gut-bacterial-communities-of-two-cerambycidae-species-coleoptera
#18
Jeong Myeong Kim, Min-Young Choi, Jae-Woo Kim, Shin Ae Lee, Jae-Hyung Ahn, Jaekyeong Song, Seong-Hyun Kim, Hang-Yeon Weon
The gut bacterial community of wood-feeding beetles has been examined for its role on plant digestion and biocontrol method development. Monochamus alternatus and Psacothea hilaris, both belonging to the subfamily Lamiinae, are woodfeeding beetles found in eastern Asia and Europe and generally considered as destructive pests for pine and mulberry trees, respectively. However, limited reports exist on the gut bacterial communities in these species. Here, we characterized gut bacterial community compositions in larva and imago of each insect species reared with host tree logs and artificial diets as food sources...
January 2017: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/28034577/10-lessons-learned-by-a-misguided-physician
#19
REVIEW
Barry E Levin
It was a great and humbling honor to receive the 2016 Distinguished Career Award from my SSIB colleagues. This paper summarizes the major points of my DCA talk at the 2016 annual meeting. It is a reflection on my 50year medical and research career and 10 lessons I have learned over those years which might be of help to young investigators near the beginning of their own research careers. These lessons include: the value of being receptive to the opportunities provided you; how clinician-scientists can serve as critical role models for young investigators like me and a history of how my career developed as a result of their influence; the importance of carefully examining your own data, particularly when it doesn't agree with your preconceived ideas; the critical role that students, postdocs and PhD (and even veterinarian) colleagues can play in developing one's career; the likelihood that your career path will have many interesting twists and turns determined by changes in your own scientific interests and how rewarding various areas of research focus are to you; the importance of building a close-knit laboratory staff family; the fact that science and romance can mix...
December 26, 2016: Physiology & Behavior
https://www.readbyqxmd.com/read/28009106/metabolic-effects-of-lactobacillus-reuteri-dsm-17938-in-patients-with-type-2-diabetes-a-randomized-controlled-trial
#20
Reza Mobini, Valentina Tremaroli, Marcus Ståhlman, Fredrik Karlsson, Max Levin, Maria Ljungberg, Maja Sohlin, Heléne Bertéus Forslund, Rosie Perkins, Fredrik Bäckhed, Per-Anders Jansson
AIMS: To investigate the metabolic effects of 12-week oral supplementation with Lactobacillus reuteri DSM 17938 in patients with type 2 diabetes on insulin therapy. MATERIALS AND METHODS: In a double-blind trial, we randomized 46 patients with type 2 diabetes to placebo or a low (10(8) CFU/day) or high dose (10(10) CFU/day) of L. reuteri DSM 17938 for 12 weeks. The primary endpoint was the effect of supplementation on glycated hemoglobin (HbA1c). Secondary endpoints were insulin sensitivity (assessed by glucose clamp), liver fat content, body composition, body fat distribution, fecal microbiota composition and serum bile acids...
December 23, 2016: Diabetes, Obesity & Metabolism
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