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https://www.readbyqxmd.com/read/28431577/dichloroacetic-acid-induced-testicular-toxicity-in-male-rats-and-the-protective-effect-of-date-fruit-extract
#1
Amira El Arem, Lamia Lahouar, Emna Behija Saafi, Amira Thouri, Fatma Ghrairi, Zohra Houas, Fadoua Neffati, Lotfi Achour
BACKGROUND: The present study was designed to investigate the protective effect of aqueous date extract (ADE) against the dichloroacetic acid (DCA)-induced testicular injury in rats. METHODS: Forty-eight male Wistar rats were randomly divided into six groups of eight: group I served as the control; group II was given ADE (4 ml/kg) by gavage; groups III and IV received DCA at 0.5 and 2 g/L drinking water, respectively; and groups V and VI received DCA at 0.5 and 2 g/L drinking water, respectively, before ADE administration...
April 22, 2017: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28428715/impact-of-interferon-free-antivirus-therapy-on-lipid-profiles-in-patients-with-chronic-hepatitis-c-genotype-1b
#2
Daisuke Endo, Kenichi Satoh, Noritomo Shimada, Atsushi Hokari, Yoshio Aizawa
AIM: To investigate the influence of interferon-free antivirus therapy on lipid profiles in chronic hepatitis C virus genotype 1b (HCV1b) infection. METHODS: Interferon-free antiviral agents were used to treat 276 patients with chronic HCV1b infection, and changes in serum lipids of those who achieved sustained virologic response (SVR) were examined. The treatment regimen included 24 wk of daclatasvir plus asunaprevir (DCV + ASV) or 12 wk of sofosbuvir plus ledipasvir (SOF + LDV)...
April 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28426747/metabolic-analysis-of-radioresistant-medulloblastoma-stem-like-clones-and-potential-therapeutic-targets
#3
Lue Sun, Takashi Moritake, Kazuya Ito, Yoshitaka Matsumoto, Hironobu Yasui, Hidehiko Nakagawa, Aki Hirayama, Osamu Inanami, Koji Tsuboi
Medulloblastoma is a fatal brain tumor in children, primarily due to the presence of treatment-resistant medulloblastoma stem cells. The energy metabolic pathway is a potential target of cancer therapy because it is often different between cancer cells and normal cells. However, the metabolic properties of medulloblastoma stem cells, and whether specific metabolic pathways are essential for sustaining their stem cell-like phenotype and radioresistance, remain unclear. We have established radioresistant medulloblastoma stem-like clones (rMSLCs) by irradiation of the human medulloblastoma cell line ONS-76...
2017: PloS One
https://www.readbyqxmd.com/read/28426722/interactions-between-mitoneet-and-naf-1-in-cells
#4
Ola Karmi, Sarah H Holt, Luhua Song, Sagi Tamir, Yuting Luo, Fang Bai, Ammar Adenwalla, Merav Darash-Yahana, Yang-Sung Sohn, Patricia A Jennings, Rajeev K Azad, Jose' N Onuchic, Faruck Morcos, Rachel Nechushtai, Ron Mittler
The NEET proteins mitoNEET (mNT) and nutrient-deprivation autophagy factor-1 (NAF-1) are required for cancer cell proliferation and resistance to oxidative stress. NAF-1 and mNT are also implicated in a number of other human pathologies including diabetes, neurodegeneration and cardiovascular disease, as well as in development, differentiation and aging. Previous studies suggested that mNT and NAF-1 could function in the same pathway in mammalian cells, preventing the over-accumulation of iron and reactive oxygen species (ROS) in mitochondria...
2017: PloS One
https://www.readbyqxmd.com/read/28422755/%C3%AE-klotho-deficiency-protects-against-obesity-through-a-crosstalk-between-liver-microbiota-and-brown-adipose-tissue
#5
Emmanuel Somm, Hugues Henry, Stephen J Bruce, Sébastien Aeby, Marta Rosikiewicz, Gerasimos P Sykiotis, Mohammed Asrih, François R Jornayvaz, Pierre Damien Denechaud, Urs Albrecht, Moosa Mohammadi, Andrew Dwyer, James S Acierno, Kristina Schoonjans, Lluis Fajas, Gilbert Greub, Nelly Pitteloud
β-Klotho (encoded by Klb) is the obligate coreceptor mediating FGF21 and FGF15/19 signaling. Klb-/- mice are refractory to beneficial action of pharmacological FGF21 treatment including stimulation of glucose utilization and thermogenesis. Here, we investigated the energy homeostasis in Klb-/- mice on high-fat diet in order to better understand the consequences of abrogating both endogenous FGF15/19 and FGF21 signaling during caloric overload. Surprisingly, Klb-/- mice are resistant to diet-induced obesity (DIO) owing to enhanced energy expenditure and BAT activity...
April 20, 2017: JCI Insight
https://www.readbyqxmd.com/read/28422200/enhancing-mri-of-liver-metastases-with-a-zwitterionized-biodegradable-dendritic-contrast-agent
#6
Xiaoxuan Zhou, Mingzhou Ye, Yuxin Han, Jianbin Tang, Yue Qian, Hongjie Hu, Youqing Shen
Metastasis is the main reason for cancer-associated mortality, and accurate diagnostic imaging of metastases is critical for the clinical administration and tailoring personalized treatments for metastatic tumors. However, magnetic resonance imaging of metastases in the liver is impeded by its low sensitivity because the currently used contrast agents accumulate in hepatocytes and Kupffer cells instead of cancer cells. Herein, a 4(th) generation zwitterionized biodegradable dendritic contrast agent (DCA) with a size of ca...
April 19, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28417341/external-validation-of-a-nomogram-including-the-computed-tomography-imaging-score-to-predict-indolent-renal-masses
#7
X Chen, B Wan, D Yang, H Zhao, W Tan
PURPOSE: To assess a nomogram including the computed tomography (CT) score and body mass index (BMI) that was constructed to predict indolent diseases in a cohort of patients with renal masses. MATERIALS AND METHODS: The data collected from patients undergoing partial nephrectomy (PN) or radical nephrectomy (RN) between January 2012 and September 2016 were analyzed. Two urologic surgeons and a radiologist reviewed the images to determine the CT score. Postoperative pathological assessment was performed to categorize renal masses as either indolent or aggressive...
April 17, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28412062/development-and-internal-validation-of-a-novel-model-to-identify-the-candidates-for-extended-pelvic-lymph-node-dissection-in-prostate-cancer
#8
Giorgio Gandaglia, Nicola Fossati, Emanuele Zaffuto, Marco Bandini, Paolo Dell'Oglio, Carlo Andrea Bravi, Giuseppe Fallara, Francesco Pellegrino, Luigi Nocera, Pierre I Karakiewicz, Zhe Tian, Massimo Freschi, Rodolfo Montironi, Francesco Montorsi, Alberto Briganti
BACKGROUND: Preoperative assessment of the risk of lymph node invasion (LNI) is mandatory to identify prostate cancer (PCa) patients who should receive an extended pelvic lymph node dissection (ePLND). OBJECTIVE: To update a nomogram predicting LNI in contemporary PCa patients with detailed biopsy reports. DESIGN, SETTING, AND PARTICIPANTS: Overall, 681 patients with detailed biopsy information, evaluated by a high-volume uropathologist, treated with radical prostatectomy and ePLND between 2011 and 2016 were identified...
April 12, 2017: European Urology
https://www.readbyqxmd.com/read/28411965/dynamic-cerebral-autoregulation-assessment-using-extracranial-internal-carotid-artery-doppler-ultrasonography
#9
Nai-Fang Chi, Hsiao-Lun Ku, Chen-Yen Wang, Yanhui Liu, Lung Chan, Ying-Chin Lin, Chung-Kang Peng, Vera Novak, Han-Hwa Hu, Chaur-Jong Hu
Transcranial Doppler ultrasonography of the middle cerebral artery (MCA) is frequently used to assess dynamic cerebral autoregulation (dCA); however, this is difficult in patients with poor temporal bone windows. In the study described here, we investigated the agreement and sensitivity of dCA indices determined from the extracranial internal carotid artery (ICA) and those determined from the MCA. Measurements for 32 stroke patients and 59 controls were analyzed. Measurement of the mean flow correlation index (Mx) and transfer function analysis based on spontaneous blood pressure fluctuation were simultaneously performed for the extracranial ICA and MCA...
April 12, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28410193/metabolic-targeting-of-egfrviii-pdk1-axis-in-temozolomide-resistant-glioblastoma
#10
Kiran K Velpula, Maheedhara R Guda, Kamlesh Sahu, Jack Tuszynski, Swapna Asuthkar, Sarah E Bach, Justin D Lathia, Andrew J Tsung
Glioblastomas are characterized by amplification of EGFR. Approximately half of tumors with EGFR over-expression also express a constitutively active ligand independent EGFR variant III (EGFRvIII). While current treatments emphasize surgery followed by radiation and chemotherapy with Temozolomide (TMZ), acquired chemoresistance is a universal feature of recurrent GBMs. To mimic the GBM resistant state, we generated an in vitro TMZ resistant model and demonstrated that dichloroacetate (DCA), a metabolic inhibitor of pyruvate dehydrogenase kinase 1 (PDK1), reverses the Warburg effect...
March 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/28404640/comprehensive-evaluation-of-the-bactericidal-activities-of-free-bile-acids-in-the-large-intestine-of-humans-and-rodents
#11
Masamichi Watanabe, Satoru Fukiya, Atsushi Yokota
In addition to functioning as detergents that aid digestion of dietary lipids in the intestine, some bile acids have been shown to exhibit antimicrobial activity. However, detailed information on the bactericidal activities of the diverse molecular species of bile acid in humans and rodents is largely unknown. Here, we investigated the toxicity of 14 typical human and rodent free bile acids (FBAs) by monitoring intracellular pH, membrane integrity, and viability of a human intestinal bacterium, Bifidobacterium breve JCM 1192(T), upon exposure to these FBAs...
April 12, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28398754/reversing-the-cytotoxicity-of-bile-acids-by-supramolecular-encapsulation
#12
Ying-Ming Zhang, Xun Xu, Qilin Yu, Yao-Hua Liu, Yu-Hui Zhang, Li-Xia Chen, Yu Liu
Supramolecular encapsulation has been developed into a powerful tool in clearance of toxic substances and hazardous waste from living body and external environments. Herein we tested the special efficacy of tyramine-modified β-cyclodextrin (1) in inhibiting and reversing of the inherent cytotoxicity of deoxycholic acid (DCA). The decarboxylation from tyrosine to tyramine in 1 is crucial to the mutual electrostatic communication, ultimately leading to great enhancement in binding affinity and molecular selectivity toward bile acids...
April 18, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28396527/leveraging-of-rifampicin-dosed-cynomolgus-monkeys-to-identify-bile-acid-3-o-sulfate-conjugates-as-potential-novel-biomarkers-for-organic-anion-transporting-polypeptides
#13
Rhishikesh Thakare, Hongying Gao, Rachel E Kosa, Yi-An Bi, Manthena V S Varma, Matthew Cerny, Raman Sharma, Max Kuhn, Bingshou Huang, Yiping Liu, Aijia Yu, Gregory S Walker, Mark Niosi, Larry M Tremaine, Yazen Alnouti, A David Rodrigues
In the search for novel bile acid (BA) biomarkers of liver organic anion-transporting polypeptides (OATPs), cynomolgus monkeys received oral rifampicin (RIF) at four dose levels (1, 3, 10 and 30 mg/kg) that generated plasma free Cmax values (0.06, 0.66, 2.57 and 7.79 μM, respectively) that covered the reported in vitro IC50s for OATP1B1 and OATP1B3 (≤ 1.7 μM). As expected, the area under the plasma concentration-time curve (AUC) of an OATP probe drug (intravenous (2)H4-pitavastatin, 0.2 mg/kg) was increased 1...
April 10, 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/28396176/the-single-parameter-structure-based-isopsa-assay-demonstrates-improved-diagnostic-accuracy-for-detection-of-any-prostate-cancer-and-high-grade-prostate-cancer-compared-to-a-concentration-based-assay-of-total-prostate-specific-antigen-a-preliminary-report
#14
Eric A Klein, Arnon Chait, Jason M Hafron, Kenneth M Kernen, Kannan Manickam, Andrew J Stephenson, Mathew Wagner, Hui Zhu, Aimee Kestranek, Boris Zaslavsky, Mark Stovsky
BACKGROUND: IsoPSA is a serum-based assay that predicts prostate cancer (PCa) risk by partitioning isoforms of prostate-specific antigen (PSA) with an aqueous two-phase reagent. OBJECTIVES: To determine the diagnostic accuracy of IsoPSA in identifying the presence or absence of PCa and the presence of high-grade disease in a contemporary biopsy cohort. DESIGN, SETTING, AND PARTICIPANTS: Multicenter prospective study of 261 men scheduled for prostate biopsy at five academic and community centers in the USA enrolled between August 2015 and December 2016...
April 7, 2017: European Urology
https://www.readbyqxmd.com/read/28391356/rat-precision-cut-liver-slices-predict-drug-induced-cholestatic-injury
#15
Viktoriia Starokozhko, Rick Greupink, Petra van de Broek, Nashwa Soliman, Samiksha Ghimire, Inge A M de Graaf, Geny M M Groothuis
Drug-induced cholestasis (DIC) is one of the leading manifestations of drug-induced liver injury (DILI). As the underlying mechanisms for DIC are not fully known and specific and predictive biomarkers and pre-clinical models are lacking, the occurrence of DIC is often only reported when the drug has been approved for registration. Therefore, appropriate models that predict the cholestatic potential of drug candidates and/or provide insight into the mechanism of DIC are highly needed. We investigated the application of rat precision-cut liver slices (PCLS) to predict DIC, using several biomarkers of cholestasis: hepatocyte viability, intracellular accumulation of total as well as individual bile acids and changes in the expression of genes known to play a role in cholestasis...
April 8, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28385437/effect-of-prior-silane-application-on-the-bond-strength-of-a-universal-adhesive-to-a-lithium-disilicate-ceramic
#16
André Fábio Vasconcelos Moro, Amanda Barreto Ramos, Gustavo Miranda Rocha, Cesar Dos Reis Perez
STATEMENT OF PROBLEM: Universal adhesives combine silane and various monomers in a single bottle to make them more versatile. Their adhesive performance is unclear. PURPOSE: The purpose of this in vitro study was to assess the effects of an additional silane application before using a universal adhesive on the adhesion between a disilicate glass ceramic and a composite resin by using a microshear bond strength test (μSBS) and fracture analysis immediately and after thermocycling...
April 3, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28381740/the-associations-between-circulating-bile-acids-and-the-muscle-volume-in-patients-with-non-alcoholic-fatty-liver-disease-nafld
#17
Yoshinao Kobayashi, Nagisa Hara, Ryosuke Sugimoto, Rumi Mifuji-Moroka, Hideaki Tanaka, Akiko Eguchi, Motoh Iwasa, Hiroshi Hasegawa, Kazuko Iwata, Yoshiyuki Takei, Osamu Taguchi
Objective Non-alcoholic fatty liver disease (NAFLD) is frequently associated with obesity, dyslipidemia and type-2 diabetes mellitus. Bile acids (BAs) bind to the farnesoid X receptor (FXR) and G protein-coupled receptor 5 (TGR5), which are involved in lipid and glucose metabolism and energy expenditure. The present study aimed to determine associations between the circulating BAs and the skeletal muscle volume (SMV), and lipid and glucose metabolism in patients with NAFLD. Methods Serum BAs and metabolic parameters were measured in 55 patients with NAFLD (median age, 55 years)...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28373645/surface-pollen-distribution-from-alpine-vegetation-in-eastern-tibet-china
#18
Yun Zhang, Zhaochen Kong, Zhenjing Yang, Li Wang, Xiaohong Duan
We explore the relationship between modern pollen spectra and vegetation patterns in the Eastern Tibet, China in order to provide information on the representation of pollen taxa and improve the general knowledge of vertical pollen transport. Forty-two modern pollen samples collected in surface soil along two altitudinal transects allowed conclusions on vertical pollen dispersal from the alpine region of Dingqing County, Changdu district in Tibet. Discriminant analyses and detrended correspondence analysis (DCA) of 24 pollen taxa were used to further discuss the difference of modern pollen spectra in these alpine vegetation zones...
April 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28371852/improvement-in-the-quality-of-hba1c-determination-by-using-commutable-specimens-with-ifcc-assigned-values
#19
Rui Zhou, Zhi-Qi Gao, Qing Tong, Chang Zuo, Zhi-Xin Song, Wei Wang, Qing-Tao Wang
Background: To assess the usefulness of commutable secondary reference materials with International Federation of Clinical Chemistry (IFCC)-assigned values, for improving the quality of hemoglobin A1c (HbA 1c ) determination. Methods: We recalibrated and evaluated 3 point-of-care-test (POCT) devices via 3 different method-specific central laboratory analyzers that were calibrated using commutable specimens with IFCC-assigned values. The staff members who performed POCT were also evaluated before and after training...
March 21, 2017: Laboratory Medicine
https://www.readbyqxmd.com/read/28347634/ten-year-outcomes-of-monomorphic-ventricular-tachycardia-catheter-ablation-in-repaired-tetralogy-of-fallot
#20
Mikaël Laredo, Robert Frank, Xavier Waintraub, Estelle Gandjbakhch, Laurence Iserin, Sebastien Hascoët, Caroline Himbert, Yves Gallais, Françoise Hidden-Lucet, Guillaume Duthoit
BACKGROUND: Monomorphic ventricular tachycardia (MVT) is common in adults with repaired tetralogy of Fallot (TOF), and is associated with sudden cardiac death. Management of MVT is not defined, and results of catheter ablation (CA) are limited. AIMS: To evaluate long-term outcomes of MVT CA in repaired TOF. METHODS: Thirty-four patients (mean age 32±10.3 years; 59% male) with repaired TOF underwent CA for symptomatic MVT between 1990 and 2012 in our centre; direct-current ablation (DCA) was used in 6%, radiofrequency followed by DCA in 29% and radiofrequency alone in 65%...
March 24, 2017: Archives of Cardiovascular Diseases
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