keyword
MENU ▼
Read by QxMD icon Read
search

DCA

keyword
https://www.readbyqxmd.com/read/28819708/in-situ-remediation-of-chlorinated-solvent-contaminated-groundwater-using-zvi-organic-carbon-amendment-in-china-field-pilot-test-and-full-scale-application
#1
Jie Yang, Liang Meng, Lin Guo
Chlorinated solvents in groundwater pose threats to human health and the environment due to their carcinogenesis and bioaccumulation. These problems are often more severe in developing countries such as China. Thus, methods for chlorinated solvent-contaminated groundwater remediation are urgently needed. This study presents a technique of in situ remediation via the direct-push amendment injection that enhances the reductive dechlorination of chlorinated solvents in groundwater in the low-permeability aquifer...
August 18, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28810730/hydrogen-isotope-fractionation-during-biodegradation-of-1-2-dichloroethane-potential-for-pathway-identification-using-a-multi-element-c-cl-and-h-isotope-approach
#2
Jordi Palau, Orfan Shouakar-Stash, Siti Hatijah Mortan, Rong Yu, Monica Rosell, Ernest Marco-Urrea, David L Freedman, Ramon Aravena, Albert Soler, Daniel Hunkeler
Even though multi-element isotope fractionation patterns provide crucial information to identify contaminant degradation pathways in the field, those involving hydrogen are still lacking for many halogenated groundwater contaminants and degradation pathways. This study investigates for the first time hydrogen isotope fractionation during both aerobic and anaerobic biodegradation of 1,2-dichloroethane (1,2-DCA) using five microbial cultures. Transformation-associated isotope fractionation values (ε_bulk^H) were: -115 ± 18‰ (aerobic C-H bond oxidation), -34 ± 4‰ and -38 ± 4‰ (aerobic C-Cl bond cleavage via hydrolytic dehalogenation), -57 ± 3‰ and -77 ± 9‰ (anaerobic C-Cl bond cleavage via reductive dihaloelimination)...
August 16, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28806923/historical-biogeography-and-ecological-niche-modelling-of-the-asimina-disepalum-clade-annonaceae-role-of-ecological-differentiation-in-neotropical-asian-disjunctions-and-diversification-in-asia
#3
Pui-Sze Li, Daniel C Thomas, Richard M K Saunders
BACKGROUND: The Asimina-Disepalum clade (Annonaceae subfam. Annonoideae tribe Annoneae) includes a major Neotropical-Asian biogeographical disjunction. We evaluate whether this disjunction can be explained by the Eocene boreotropics hypothesis, which relies on the existence of extensive boreotropical forests during the Late Palaeocene-Early Eocene thermal maximum (52-50 Ma), followed by disruption of boreotropical vegetation during post-Eocene cooling. Molecular dating using an uncorrelated relaxed molecular clock (UCLD) model with two fossil calibrations, ancestral range estimation, and ecological niche modelling across evolutionary time were performed...
August 14, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/28799620/long-term-bleeding-risk-prediction-in-real-world-patients-with-atrial-fibrillation-comparison-of-the-has-bled-and-abc-bleeding-risk-scores-the-murcia-atrial-fibrillation-project
#4
María Asunción Esteve-Pastor, José Miguel Rivera-Caravaca, Vanessa Roldan, Vicente Vicente, Mariano Valdés, Francisco Marín, Gregory Y H Lip
Risk scores in patients with atrial fibrillation (AF) based on clinical factors alone generally have only modest predictive value for predicting high risk patients that sustain events. Biomarkers might be an attractive prognostic tool to improve bleeding risk prediction. The new ABC-Bleeding score performed better than HAS-BLED score in a clinical trial cohort but has not been externally validated. It was the aim of this study to compare the predictive performance of the ABC-Bleeding score compared to HAS-BLED score in an independent "real-world" anticoagulated AF patients with long-term follow-up...
August 11, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28774887/suppressed-hepatic-bile-acid-signalling-despite-elevated-production-of-primary-and-secondary-bile-acids-in-nafld
#5
Na Jiao, Susan S Baker, Adrian Chapa-Rodriguez, Wensheng Liu, Colleen A Nugent, Maria Tsompana, Lucy Mastrandrea, Michael J Buck, Robert D Baker, Robert J Genco, Ruixin Zhu, Lixin Zhu
OBJECTIVE: Bile acids are regulators of lipid and glucose metabolism, and modulate inflammation in the liver and other tissues. Primary bile acids such as cholic acid and chenodeoxycholic acid (CDCA) are produced in the liver, and converted into secondary bile acids such as deoxycholic acid (DCA) and lithocholic acid by gut microbiota. Here we investigated the possible roles of bile acids in non-alcoholic fatty liver disease (NAFLD) pathogenesis and the impact of the gut microbiome on bile acid signalling in NAFLD...
August 3, 2017: Gut
https://www.readbyqxmd.com/read/28753781/prediction-of-prostate-cancer-external-validation-of-the-erspc-risk-calculator-in-a-contemporary-dutch-clinical-cohort
#6
Maudy Gayet, Christophe K Mannaerts, Daan Nieboer, Harrie P Beerlage, Hessel Wijkstra, Peter F A Mulders, Monique J Roobol
BACKGROUND: The validity of prediction models needs external validation to assess their value beyond the original development setting. OBJECTIVE: To report the diagnostic accuracy of the European Randomized Study of Screening for Prostate Cancer (ERSPC) risk calculator (RC)3 and RC4 in a contemporary Dutch clinical cohort. DESIGN, SETTING, AND PARTICIPANTS: We retrospectively identified all men who underwent prostate biopsy (PBx) in the Jeroen Bosch Hospital, The Netherlands, between 2007 and 2016...
August 4, 2016: European Urology Focus
https://www.readbyqxmd.com/read/28753736/can-quantity-of-amniotic-fluid-reliably-predict-postnatal-renal-function-in-boys-with-posterior-urethral-valves-a-decision-curve-analysis
#7
Luke Harper, Alice Waubant, Julien Vignes, Sara Amat, Eric Dobremez, Yan Lefevre, Cyril Ferdynus
OBJECTIVE: Prenatal management of male fetuses with suspected posterior urethral valves depends on reliable markers for postnatal long-term renal function. Whether ultrasound parameters, including the presence or absence of oligohydramnios, are reliable remains the subject of debate. We decided to evaluate the reliability of quantity of amniotic fluid to predict postnatal renal function using decision curve analysis (DCA), a method for evaluating the clinical utility of a diagnostic test...
July 28, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/28743073/in-situ-biodegradation-potential-of-1-2-dca-and-vc-at-sites-with-different-hydrogeological-settings
#8
R C M Nobre, M M M Nobre, T M P Campos, D Ogles
This paper investigates the feasibility of applying in-situ Bioremediation (ISB) to three sites contaminated with vinyl chloride and/or chlorinated alkanes such as 1,2-DCA and 1,1,2-TCA, presenting distinct hydrogeological settings and history of contaminant loading. Biotransformation of these compounds is well established in laboratory studies and pure cultures. Due to confidential aspects, however, few field data are available to support real case studies to the predictability of their fate and lifetime in soil and groundwater...
July 15, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28734906/results-from-15years-of-quality-surveillance-for-a-national-indigenous-point-of-care-testing-program-for-diabetes
#9
Mark Shephard, Anne Shephard, Bridgit McAteer, Tamika Regnier, Kristina Barancek
INTRODUCTION: Diabetes is a major health problem for Australia's Aboriginal and Torres Strait Islander peoples. Point-of-care testing for haemoglobin A1c (HbA1c) has been the cornerstone of a long-standing program (QAAMS) to manage glycaemic control in Indigenous people with diabetes and recently, to diagnose diabetes. METHODS: The QAAMS quality management framework includes monthly testing of quality control (QC) and external quality assurance (EQA) samples. Key performance indicators of quality include imprecision (coefficient of variation [CV%]) and percentage acceptable results...
July 19, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28731120/na3v2-po4-3-coated-by-n-doped-carbon-from-ionic-liquid-as-cathode-materials-for-high-rate-and-long-life-na-ion-batteries
#10
Yu Yao, Yu Jiang, Hai Yang, Xizhen Sun, Yan Yu
A facile and simple hydrothermal assisted sol-gel route was developed to prepare nitrogen doped carbon coated Na3V2(PO4)3 nanocomposites (denoted as NVP@C-N) as cathodes for sodium ion batteries (NIBs). An ionic liquid (EMIm-dca) was used as the nitrogen doped carbon source. The optimized N-doped carbon coated Na3V2(PO4)3 (denoted as NVP@C-N150) displays a very thin and uniform N-doped carbon coating layer (thickness: ∼2 nm), showing an excellent sodium storage performance (85 mA h g(-1) at 20 C after 5000 cycles) and high rate capability (71 mA h g(-1) at 80 C)...
August 3, 2017: Nanoscale
https://www.readbyqxmd.com/read/28714513/in-vivo-evaluation-of-tumour-acidosis-for-assessing-the-early-metabolic-response-and-onset-of-resistance-to-dichloroacetate-by-using-magnetic-resonance-ph-imaging
#11
Annasofia Anemone, Lorena Consolino, Laura Conti, Francesca Reineri, Federica Cavallo, Silvio Aime, Dario Livio Longo
Dichloroacetate (DCA) can reverse the glycolytic phenotype that is responsible of increased lactate production and extracellular pH acidification in cancer cells. Magnetic resonance imaging-chemical exchange saturation transfer (MRI-CEST) pH mapping is a novel non-invasive imaging approach that can measure in vivo extracellular tumour pH. We examined whether MRI-CEST pH mapping can monitor in vivo changes in tumour acidosis for assessing treatment response to DCA. Cell viability and extracellular pH were assessed in TS/A breast cancer cells treated with 1-10 mM DCA for 24 h in normoxia or hypoxia (1% O2) conditions...
August 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28714067/evaluation-of-plastic-scintillator-detector-for-small-field-stereotactic-patient-specific-quality-assurance
#12
Yujiao Qin, Stephen J Gardner, Joshua Kim, Yimei Huang, Ning Wen, Anthony Doemer, Indrin J Chetty
PURPOSE: To evaluate the performance of a commercial plastic scintillator detector (PSD) for small-field stereotactic patient-specific quality assurance (QA) measurements using flattening-filter-free beam. METHODS: A total of ten spherical targets (volume range: [0.03cc-2cc]) were planned with two techniques: (1) Dynamic Conformal Arc (DCA-10 plans), and (2) Volumetric Modulated Arc Therapy (VMAT-10 plans). All plans were generated using Varian Eclipse treatment planning system, and AcurosXB v...
July 17, 2017: Medical Physics
https://www.readbyqxmd.com/read/28711706/haemolytic-activity-of-formyl-and-acetyl-derivatives-of-bile-acids-and-their-gramine-salts
#13
Weronika Kozanecka-Okupnik, Beata Jasiewicz, Tomasz Pospieszny, Monika Matuszak, Lucyna Mrówczyńska
Bile acids (lithocholic: LCA, deoxycholic: DCA and cholic: CA) and their formyl- and acetyl- derivatives can be used as starting material in chemical synthesis of compounds with different biological activity strongly depended on their chemical structures. Our previous studies showed that biological activity of bile acids salts with gramine toward human erythrocytes was significantly different from the activity of bile acids alone. Moreover, gramine effectively modified the membrane perturbing activity of other steroids...
July 12, 2017: Steroids
https://www.readbyqxmd.com/read/28704214/bile-acids-upregulate-brca1-and-downregulate-estrogen-receptor-1-gene-expression-in-ovarian-cancer-cells
#14
Qunyan Jin, Olivier Noel, Mai Nguyen, Lionel Sam, Glenn S Gerhard
Two major risk factors for ovarian cancer include loss-of-function mutations in the BRCA1 (breast cancer 1, early onset) gene and aspects of estrogen metabolism. Modulation of the levels of the normal BRCA1 allele and estrogen receptor expression may therefore be a preventive strategy. Consensus binding motifs for the bile acid-responsive transcription factor farnesoid X receptor were identified in the BRCA1 and estrogen receptor 1 (ESR1) and estrogen receptor 2 (ESR2) genes, supported by chromatin immunoprecipitation sequencing data...
July 12, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28698546/obesity-induces-organ-and-tissue-specific-tight-junction-restructuring-and-barrier-deregulation-by-claudin-switching
#15
Rizwan Ahmad, Bilal Rah, Dhundy Bastola, Punita Dhawan, Amar B Singh
Obesity increases susceptibility to multiple organ disorders, however, underlying mechanisms remain unclear. The subclinical inflammation assisted by obesity-induced gut permeability may underlie obesity-associated co-morbidities. Despite eminent clinical significance of the obesity led gut barrier abnormalities, its precise molecular regulation remains unclear. It is also unknown whether barrier deregulations, similar to the gut, characterize other vital organs in obese individuals. The claudin family of proteins is integral to the tight junction (TJ), the apical cell-cell adhesion and a key regulator of the epithelial barrier...
July 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28689738/unconjugated-bile-acids-in-rat-brain-analytical-method-based-on-lc-esi-ms-ms-with-chemical-derivatization-and-estimation-of-their-origin-by-comparison-to-serum-levels
#16
Tatsuya Higashi, Shui Watanabe, Koki Tomaru, Wataru Yamazaki, Kazumi Yoshizawa, Shoujiro Ogawa, Hidenori Nagao, Kouichi Minato, Masamitsu Maekawa, Nariyasu Mano
Although some studies have revealed the implication of bile acids (BAs) and neurological diseases, the levels and origin of the BAs in the brain are not fully understood. In this study, we first developed and validated a sensitive and specific method for the determination of three unconjugated BAs [cholic acid (CA), chenodeoxycholic acid (CDCA) and deoxycholic acid (DCA)] in the rat brain by liquid chromatography/electrospray ionization-tandem mass spectrometry combined with chemical derivatization. The measured brain concentrations (mean±standard deviation, n=10) of normal rats were 58...
July 8, 2017: Steroids
https://www.readbyqxmd.com/read/28688958/novel-derivatives-of-deoxycholic-acid-bearing-aliphatic-or-cyclic-diamine-moieties-at-the-c-3-position-synthesis-and-evaluation-of-anti-proliferative-activity
#17
Irina I Popadyuk, Andrey V Markov, Valeriya O Babich, Oksana V Salomatina, Evgeniya B Logashenko, Marina A Zenkova, Nariman F Salakhutdinov
A new library of deoxycholic acid derivatives bearing nitrogen-containing moieties at the C-3 position was synthesised from epoxy derivative 1 via an epoxide ring-opening reaction promoted by aliphatic or cyclic diamines and fully characterised by NMR and mass-spectroscopy. The synthesised compounds were screened for cytotoxicity against four human tumour cell lines. The results showed that some of the novel diamine-bearing derivatives displayed improved anti-proliferative activities over the parent compound DCA...
June 27, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28679557/identification-and-characterization-of-daurichromenic-acid-synthase-active-in-anti-hiv-biosynthesis
#18
Miu Iijima, Ryosuke Munakata, Hironobu Takahashi, Hiromichi Kenmoku, Ryuichi Nakagawa, Takeshi Kodama, Yoshinori Asakawa, Ikuro Abe, Kazufumi Yazaki, Fumiya Kurosaki, Futoshi Taura
Daurichromenic acid (DCA) synthase catalyzes the oxidative cyclization of grifolic acid to produce DCA, an anti-HIV meroterpenoid isolated from Rhododendron dauricum We identified a novel cDNA encoding DCA synthase by transcriptome-based screening from young leaves of R. dauricum The gene coded for a 533-amino acid polypeptide with moderate homologies to flavin adenine dinucleotide oxidases from other plants. The primary structure contained an amino-terminal signal peptide and conserved amino acid residues to form bicovalent linkage to the flavin adenine dinucleotide isoalloxazine ring at histidine-112 and cysteine-175...
August 2017: Plant Physiology
https://www.readbyqxmd.com/read/28675968/effects-of-a-high-o2-dynamic-controlled-atmosphere-technology-on-the-browning-of-postharvest-white-mushroom-agaricus-bisporus-in-relation-to-energy-metabolism
#19
Ling Li, Han Sun, Hiroaki Kitazawa, Xiangyou Wang
Browning is one of the main problems in senescence of mushrooms, and it is also one of the most important attributes accounting for the loss of the quality and reduction in market value. In order to study the relationship between the energy metabolism and the browning of white mushroom under high O2 dynamic-controlled atmosphere (HO-DCA), mushrooms were stored in 100% O2 (SCA1), 80% O2 + 20% CO2 (SCA2), 100% O2 for three days and then transferred into the treatment of 80% O2 + 20% CO2 (HO-DCA) at 2 ± 1 ℃ and air as control...
July 2017: Food Science and Technology International, Ciencia y Tecnología de Los Alimentos Internacional
https://www.readbyqxmd.com/read/28674876/bead-based-and-multiplexed-immunoassays-for-protein-profiling-via-sequential-affinity-capture
#20
Elin Birgersson, Jochen M Schwenk, Burcu Ayoglu
Antibody microarrays offer high-throughput immunoassays for multiplexed analyses of clinical samples. For such approaches, samples are either labeled in solution to enable a direct readout on the single binder assay format or detected by matched pairs of capture and detection antibodies in dual binder assay format, also known as sandwich assays. Aiming to benefit from the flexibility and capacity offered by single binder assay readout and the specificity and sensitivity of dual binder assays, we developed a multiplexed dual binder procedure that is based on a sequential, rather than combined, antigen binding...
2017: Methods in Molecular Biology
keyword
keyword
17518
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"