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https://www.readbyqxmd.com/read/29922396/effect-of-intracranial-stenosis-revascularization-on-dynamic-and-static-cerebral-autoregulation
#1
Santiago Ortega-Gutierrez, Edgar A Samaniego, Amy Huang, Arjun Masurkar, Binbin Zheng-Lin, Colin P Derdeyn, David Hasan, Randolph Marshall, Nils Petersen
Introduction: Severe intracranial stenosis might lead to acute cerebral ischemia. It is imperative to better assess patients who may benefit from immediate reperfusion and blood pressure management to prevent injury to peri-infarct tissue. Methods: We assessed cerebral autoregulation using static and dynamic methods in an 81-year-old woman suffering acute cerebral ischemia from severe intracranial stenosis in the petrous segment of the left internal carotid artery (LICA)...
June 2018: Journal of Vascular and Interventional Neurology
https://www.readbyqxmd.com/read/29913407/the-effect-of-dichloroacetate-in-mouse-models-of-epilepsy
#2
Dylan Durie, Tanya S McDonald, Karin Borges
A recent report has found that glucose oxidation and the activity of pyruvate dehydrogenase (PDH) are reduced in the chronic stage of the pilocarpine mouse epilepsy model. This is likely caused by increased phosphorylation by PDH kinase of the E1α subunit of PDH, downregulating its activity. Inhibition of this phosphorylation has not yet been explored as a possible approach to treat epilepsy. Chronic dichloroacetate (DCA, 50 and 100 mg/kg/day) treatment was tested in acute seizure and the chronic pilocarpine models...
June 15, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29908920/a-new-metastatic-lymph-node-classification-based-survival-predicting-model-in-patients-with-small-bowel-adenocarcinoma-a-derivation-and-validation-study
#3
Shan Wu, Jin-Nan Chen, Qing-Wei Zhang, Chao-Tao Tang, Xin-Tian Zhang, Ming-Yu Tang, Xiao-Bo Li, Zhi-Zheng Ge
BACKGROUND: Current methods of lymph node (LN) staging are controversial in predicting the survival of SBA. We aimed to develop an alternative LN-classification-based nomogram to individualize SBA prognosis. METHODS: Based on the data from the Surveillance, Epidemiology, and End Results (SEER) database of patients diagnosed with SBA between 2004 and 2014, we identified the cut-off points for the number of LNs examined and the number found to be metastatic using the K-adaptive partitioning (KAPS) algorithm...
June 13, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29907593/the-role-of-pyruvate-dehydrogenase-kinase-4-pdk4-in-bladder-cancer-and-chemoresistance
#4
Benjamin L Woolbright, Dharamainder Choudhary, Andrew Mikhalyuk, Cassandra Trammel, Sambantham Shanmugam, Erika Abbott, Carol C Pilbeam, John A Taylor
Advanced bladder cancer (BCa) remains a major source of mortality, with poor treatment options. Cisplatin based chemotherapy is the standard treatment, however many patients are or become resistant. One potential cause of chemoresistance is the Warburg Effect, a metabolic switch to aerobic glycolysis that occurs in many cancers. Upregulation of the pyruvate dehydrogenase kinase family (PDK1-4) is associated with aerobic glycolysis and chemoresistance through inhibition of the pyruvate dehydrogenase complex (PDH)...
June 15, 2018: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29905011/low-expression-of-ww-domain-containing-oxidoreductase-associates-with-hepatocellular-carcinoma-aggressiveness-and-recurrence-after-curative-resection
#5
Chenhao Zhou, Wanyong Chen, Jialei Sun, Manar Atyah, Yirui Yin, Wentao Zhang, Lei Guo, Qinghai Ye, Qiongzhu Dong, Yi Shi, Ning Ren
WW domain-containing oxidoreductase (WWOX), which has a protein-interaction domain and is regarded to be a tumor suppressor, has been known to play an important role in anti-angiogenesis and cancer progression. This study aimed to investigate prognostic values of WWOX expression in hepatocellular carcinoma (HCC) patients after hepatectomy. Additionally, we intended to formulate a valuable prognostic nomogram for HCCs. 182 HCC patients who underwent hepatectomy from January 2009 to January 2010 were enrolled in our study...
June 14, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29891454/-role-of-endoplasmic-reticulum-stress-induced-apoptosis-of-trophoblasts-in-intrahepatic-cholestasis-during-pregnancy
#6
Hai-Zhen Wang, Dan-Chun Cai, Dan-Dan Liao, Mei Zhong, Yun-Fei Gao, Chao Sheng
OBJECTIVE: To investigate the role of endoplasmic reticulum stress (ERS)-induced trophoblast apoptosis in the development of intrahepatic cholestasis during pregnancy (ICP). METHODS: Twenty pregnant women with ICP and 20 normal pregnant women undergoing cesarean section were enrolled in this study. The number of placenta syncytial knots in these women was determined using HE staining. The mRNA expressions of GRP78, CHOP, caspase-3, and caspase-7 were detected using RT-PCR in the placental tissues of the women and also in HTR-8/SVneo cells treated with different doses of deoxycholic acid (DCA)...
May 20, 2018: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/29885418/sustainable-in-situ-remediation-of-recalcitrant-organic-pollutants-in-groundwater-with-controlled-release-materials-a-review
#7
REVIEW
David O'Connor, Deyi Hou, Yong Sik Ok, Yinan Song, Ajit Sarmah, Xuanru Li, Filip M G Tack
The removal of recalcitrant organic pollutants in groundwater is a challenge being faced around the world. Achieving effective long-term remediation of contaminated aquifers faces a variety of significant issues such as back diffusion, tailing, and rebound. In recent years, some researchers have proposed the use of controlled release materials (CRMs) as a new approach to counteracting such issues. The novelty of CRMs lies in that they release their active products slowly, over prolonged periods of time, in order to sustain in situ treatments and long-term effectiveness...
June 6, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29880458/external-validation-of-chun-pcpt-erspc-kawakami-and-karakiewicz-nomograms-in-the-prediction-of-prostate-cancer-a-single-center-cohort-study
#8
Cosimo De Nunzio, Riccardo Lombardo, Giorgia Tema, Hassan Alkhatatbeh, Giorgio Gandaglia, Alberto Briganti, Andrea Tubaro
OBJECTIVES: The aim of our study was to analyze the performance of 5 different risk calculators for prostate cancer diagnosis: Prostate Cancer Prevention Trial Risk Calculator (PCPT-RC), European Randomized Study of Screening for Prostate Cancer Risk Calculator (ERSP-RC), Karakiewicz nomogram, Chun nomogram, and Kawakami Nomogram. METHODS: From 2008 onwards, we consecutively enrolled, at a single institution in Italy, men undergoing 12-core transrectal ultrasound-guided prostate needle biopsy...
June 4, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29870900/targeted-reversal-and-phosphorescence-lifetime-imaging-of-cancer-cell-metabolism-via-a-theranostic-rhenium-i-dca-conjugate
#9
Jing Yang, Qian Cao, Hang Zhang, Liang Hao, Danxia Zhou, Zhenji Gan, Zhiwei Li, Ye-Xiang Tong, Liang-Nian Ji, Zong-Wan Mao
Cancer cell metabolism is quite different from normal cells. Targeting cancer metabolism and untuning the tumor metabolic machine has emerged as a promising strategy for cancer therapy. We have developed a multi-functional Re-dca conjugate (Re-dca 2) by conjugating the metabolic modulator dichloroacetate (DCA) to mitochondria-targeted rhenium(I) complex, allowing its efficient penetration into cancer cells and selective accumulation in mitochondria, thus achieving the cancer cell metabolism reversal from glycolysis to glucose oxidation at pharmacologically relevant DCA doses...
May 25, 2018: Biomaterials
https://www.readbyqxmd.com/read/29870228/breathable-and-colorful-cellulose-acetate-based-nanofibrous-membranes-for-directional-moisture-transport
#10
Aijaz Ahmed Babar, Dongyang Miao, Nadir Ali, Jing Zhao, Xianfeng Wang, Jianyong Yu, Bin Ding
Textiles with excellent moisture transport characteristics play key role in regulating the comfort of the body, and use of color in textiles helps in developing aesthetically pleasing apparels. Herein, we report an aesthetically pleasing and breathable dual-layer cellulose acetate (CA)/dyed CA (DCA) nanofiber membrane with exceptional directional moisture transport performance. Outer layer was synthesized by subjecting CA nanofibers to hydrolysis and reactive dyeing processes, which converted moderately hydrophobic CA nanofibers into uniformly colored superhydrophilic CA nanofibers with an excellent wettability...
June 5, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29869342/self-management-challenges-and-support-needs-among-kidney-transplant-recipients-a-qualitative-study
#11
Janet M J Been-Dahmen, Jan Willem Grijpma, Erwin Ista, Jolanda Dwarswaard, Louise Maasdam, Willem Weimar, AnneLoes Van Staa, Emma K Massey
AIMS: This study investigated self-management challenges and support needs experienced by kidney transplant recipients. BACKGROUND: After kidney transplantation, recipients are expected to take an active role in self-management. However, evidence suggests that nurses experience difficulties operationalizing self-management support. Greater insight into the recipients' perspective could help to improve the adequacy and efficacy of nurse-led self-management support...
June 5, 2018: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/29865291/average-accumulative-based-time-variant-model-for-early-diagnosis-and-prognosis-of-slowly-varying-faults
#12
Funa Zhou, Ju H Park, Chenglin Wen, Po Hu
Early detection of slowly varying small faults is an essential step for fault prognosis. In this paper, we first propose an average accumulative (AA) based time varying principal component analysis (PCA) model for early detection of slowly varying faults. The AA based method can increase the fault size as well as decrease the noise energy. Then, designated component analysis (DCA) is introduced for developing an AA-DCA method to diagnose the root cause of the fault, which is helpful for the operator to make maintenance decisions...
June 3, 2018: Sensors
https://www.readbyqxmd.com/read/29863324/ph-induced-charge-reversal-amphiphile-with-cancer-cell-selective-membrane-disrupting-activity
#13
Yincheng Chang, Zehuan Huang, Yang Jiao, Jiangfei Xu, Xi Zhang
A charge-reversal amphiphile exhibiting charge conversion from negative to positive induced by pH is reported. It selectively kills cancer cells through cell membrane disruption. This amphiphile comprising an alkyl chain and anionic headgroup of acid-labile β-carboxylic amide (C16N-DCA) was prepared. In the microenvironment of normal cells with pH 7.4, the negatively charged C16N-DCA exhibited considerably reduced cytotoxicity. However, in the acidic microenvironment of cancer cells with pH 6.5-6.8, the headgroup charge of C16N-DCA changed from negative to positive under hydrolysis of the acid-labile amide group...
June 4, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29859856/takeda-g-protein-coupled-receptor-5-mechanistic-target-of-rapamycin-complex-1-signaling-contributes-to-the-increment-of-glucagon-like-peptide-1-production-after-roux-en-y-gastric-bypass
#14
Hening Zhai, Zhi Li, Miao Peng, Zhaoqi Huang, Tingfeng Qin, Linxi Chen, Hanbing Li, Heng Zhang, Weizhen Zhang, Geyang Xu
BACKGROUND: The mechanism by which Roux-en-Y Gastric Bypass (RYGB) increases the secretion of glucagon-like peptide-1 (GLP-1) remains incompletely defined. Here we investigated whether TGR5-mTORC1 signaling mediates the RYGB-induced alteration in GLP-1 production in mice and human beings. METHODS: Circulating bile acids, TGR5-mTORC1 signaling, GLP-1 synthesis and secretion were determined in lean or obese male C57BL/6 mice with or without RYGB operation, as well as in normal glycemic subjects, obese patients with type 2 diabetes before and after RYGB...
May 30, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29859053/compromised-dynamic-cerebral-autoregulation-in-patients-with-generalized-anxiety-disorder-a-study-using-transfer-function-analysis
#15
Zhen-Ni Guo, Shan Lv, Jia Liu, Zan Wang, Hang Jin, Quanli Qiu, Xin Sun, Yi Yang
BACKGROUND: Patients with generalized anxiety disorder (GAD) usually present with various neurological symptoms, but the mechanisms remain unclear. We aimed to analyze the characteristics of dynamic cerebral autoregulation (dCA) in patients with GAD. METHODS: Patients (aged ≥18 years) who were diagnosed with GAD were enrolled in this study. Medically and psychiatrically healthy volunteers were recruited as controls. Subjects received the Hamilton Rating Scale for Anxiety (HAMA) and 17-item Hamilton Depression Rating Scale (HAMD) evaluation...
June 1, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29844702/dichloroacetate-enhances-the-antitumor-efficacy-of-chemotherapeutic-agents-via-inhibiting-autophagy-in-non-small-cell-lung-cancer
#16
Xiao Lu, Dong Zhou, Bing Hou, Quan-Xing Liu, Qian Chen, Xu-Feng Deng, Zu-Bin Yu, Ji-Gang Dai, Hong Zheng
Background: Chemotherapy is still the primary adjuvant strategy of cancer therapy; however, the emergence of multi-drug resistance has been a cause for concern. Autophagy has been demonstrated to have a protective role against chemotherapeutic drugs in cancer cells, and autophagy inhibition is generally considered to be a promising therapeutic strategy. However, the paucity of effective and specific autophagy inhibitors limits its application. Purpose: The objective of this study was to explore the effect of DCA, small molecular anti-tumor agent, on the autophagy regulation and chemosensitization in NSCLC cells...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29813016/superdca-for-genome-wide-epistasis-analysis
#17
Santeri Puranen, Maiju Pesonen, Johan Pensar, Ying Ying Xu, John A Lees, Stephen D Bentley, Nicholas J Croucher, Jukka Corander
The potential for genome-wide modelling of epistasis has recently surfaced given the possibility of sequencing densely sampled populations and the emerging families of statistical interaction models. Direct coupling analysis (DCA) has previously been shown to yield valuable predictions for single protein structures, and has recently been extended to genome-wide analysis of bacteria, identifying novel interactions in the co-evolution between resistance, virulence and core genome elements. However, earlier computational DCA methods have not been scalable to enable model fitting simultaneously to 104 -105 polymorphisms, representing the amount of core genomic variation observed in analyses of many bacterial species...
May 29, 2018: Microbial Genomics
https://www.readbyqxmd.com/read/29804698/in-vivo-tissue-characterization-of-human-atherosclerotic-plaques-by-optical-coherence-tomography-a-directional-coronary-atherectomy-study-with-histopathologic-confirmation
#18
Maoto Habara, Fumiyuki Otsuka, Etsuo Tsuchikane, Mitsuyasu Terashima, Kenya Nasu, Yoshihisa Kinoshita, Akira Murata, Yoriyasu Suzuki, Yoshiaki Kawase, Munenori Okubo, Hitoshi Matsuo, Tetsuo Matsubara, Satoshi Yasuda, Hatsue Ishibashi-Ueda, Takahiko Suzuki
BACKGROUND: The histopathological validation of optical coherence tomography (OCT) in visualizing atherosclerotic plaques has been reported only in ex vivo studies. We sought to evaluate the accuracy of OCT in tissue characterization in vivo. METHODS AND RESULTS: A total of 25 patients with stable angina pectoris who underwent directional coronary atherectomy (DCA) were included in the investigation, whereby OCT was performed before and after a single debulking...
May 10, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29791882/simulation-based-assessment-of-the-impact-of-fertiliser-and-herbicide-application-on-freshwater-ecosystems-at-the-three-gorges-reservoir-in-china
#19
Björn Scholz-Starke, Li Bo, Andreas Holbach, Stefan Norra, Tilman Floehr, Henner Hollert, Martina Roß-Nickoll, Andreas Schäffer, Richard Ottermanns
Dams have profound impacts on river ecosystems, amongst them inundation of land, altered dynamics of the water body or uprising reservoir backwaters influencing tributary or upstream river sections. Along the outstandingly ecologically important Yangtze River in China, the Three Gorges Reservoir (TGR) is the largest project, covering an area of 1080 km2 . From the beginning, the dam-project came in for criticism on increasing environmental risks due to sub-merging former industrial and urban areas. We simulated dynamics of biotic and abiotic components of the TGR ecosystem (trophic guilds of aquatic organisms, hydrodynamics, nutrients), as well as the behaviour of the herbicidal substance propanil and its metabolites 3,4-Dichloroaniline (DCA) and 3,3',4,4'-tetrachloroazoxybenzene (TCAB)...
May 20, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29791298/the-influence-of-dopamine-on-cognitive-flexibility-is-mediated-by-functional-connectivity-in-young-but-not-older-adults
#20
Anne S Berry, Vyoma D Shah, William J Jagust
Dopaminergic signaling in striatum is strongly implicated in executive functions including cognitive flexibility. However, there is a paucity of multimodal research in humans defining the nature of relationships between endogenous dopamine, striatal network activity, and cognition. Here, we measured dopamine synthesis capacity in young and older adults using the PET tracer 6-[18 F]fluoro-l- m-tyrosine and examined its relationship with cognitive performance and functional connectivity during an fMRI study of task switching...
May 23, 2018: Journal of Cognitive Neuroscience
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