keyword
MENU ▼
Read by QxMD icon Read
search

BIM

keyword
https://www.readbyqxmd.com/read/28808415/foxo-signaling-pathways-as-therapeutic-targets-in-cancer
#1
REVIEW
Mohd Farhan, Haitao Wang, Uma Gaur, Peter J Little, Jiangping Xu, Wenhua Zheng
Many transcription factors play a key role in cellular differentiation and the delineation of cell phenotype. Transcription factors are regulated by phosphorylation, ubiquitination, acetylation/deacetylation and interactions between two or more proteins controlling multiple signaling pathways. These pathways regulate different physiological processes and pathological events, such as cancer and other diseases. The Forkhead box O (FOXO) is one subfamily of the fork head transcription factor family with important roles in cell fate decisions and this subfamily is also suggested to play a pivotal functional role as a tumor suppressor in a wide range of cancers...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28792534/primary-bovine-skeletal-muscle-cells-enters-apoptosis-rapidly-via-the-intrinsic-pathway-when-available-oxygen-is-removed
#2
Sissel Beate Rønning, Petter Vejle Andersen, Mona Elisabeth Pedersen, Kristin Hollung
Muscle cells undergo changes post-mortem during the process of converting muscle into meat, and this complex process is far from revealed. Recent reports have suggested programmed cell death (apoptosis) to be important in the very early period of converting muscle into meat. The dynamic balance that occurs between anti-apoptotic members, such as Bcl-2, and pro-apoptotic members (Bid, Bim) helps determine whether the cell initiates apoptosis. In this study, we used primary bovine skeletal muscle cells, cultured in monolayers in vitro, to investigate if apoptosis is induced when oxygen is removed from the growth medium...
2017: PloS One
https://www.readbyqxmd.com/read/28783173/synergistic-activity-and-heterogeneous-acquired-resistance-of-combined-mdm2-and-mek-inhibition-in-kras-mutant-cancers
#3
A N Hata, S Rowley, H L Archibald, M Gomez-Caraballo, F M Siddiqui, F Ji, J Jung, M Light, J S Lee, L Debussche, S Sidhu, R I Sadreyev, J Watters, J A Engelman
There are currently no effective targeted therapies for KRAS mutant cancers. Therapeutic strategies that combine MEK inhibitors with agents that target apoptotic pathways may be a promising therapeutic approach. We investigated combining MEK and MDM2 inhibitors as a potential treatment strategy for KRAS mutant non-small cell lung cancers (NSCLC) and colorectal carcinomas that harbor wild-type TP53. The combination of pimasertib (MEK inhibitor) and SAR405838 (MDM2 inhibitor) was synergistic and induced the expression of PUMA and BIM, led to apoptosis and growth inhibition in vitro, and tumor regression in vivo...
August 7, 2017: Oncogene
https://www.readbyqxmd.com/read/28780306/neuromedin-b-and-its-receptor-silencing-suppresses-osteoclast-generation-by-modulating-precursor-proliferation-via-m-csf-c-fms-d-type-cyclins
#4
Chae-Eun Yeo, Woo Youl Kang, Sook Jin Seong, Seungil Cho, Hae Won Lee, Young-Ran Yoon, Hyun-Ju Kim
Neuromedin B (NMB), a mammalian bombesin-like peptide, regulates diverse physiological processes, such as energy metabolism, memory and fear behavior, and cellular growth, through its cognate receptor, NMBR. In this study, we report that NMB expression was upregulated during osteoclast development and that silencing NMB or NMBR attenuated osteoclast generation mediated by macrophage colony-stimulating factor (M-CSF) and receptor activator of NF-κB ligand (RANKL). We found that knockdown of NMB or NMBR using a small hairpin RNA suppressed M-CSF-induced proliferation of osteoclast precursor cells without altering osteoclast differentiation...
August 2, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28774373/-association-between-bim-gene-and-glucocorticoid-resistance-in-children-with-acute-lymphoblastic-leukemia
#5
Jin-Yun Xu, Jian-Ming Luo
Acute lymphoblastic leukemia (ALL) is the most common malignant hematological disease in childhood. Glucocorticoids are frequently used in the chemoradiotherapy regimen for ALL and can induce the apoptosis of ALL cells through several signaling pathways, but about 10% of ALL children have poor response to glucocorticoids. Studies have revealed that glucocorticoids induce the apoptosis of ALL cells by upregulating the expression of BIM gene, and BIM gene is associated with glucocorticoid resistance in childhood ALL...
August 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28767402/mimicking-the-bim-bh3-domain-overcomes-resistance-to-egfr-tyrosine-kinase-inhibitors-in-egfr-mutant-non-small-cell-lung-cancer
#6
Jinjing Xia, Hao Bai, Bo Yan, Rong Li, Minhua Shao, Liwen Xiong, Baohui Han
Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) are widely applied to treat EGFR-mutant non-small cell lung cancer (NSCLC). BIM is a BH3 domain-containing protein encoded by BCL2L11. Some EGFR-mutant NSCLC patients showing BIM deletion polymorphism are resistant to EGFR TKIs. We retrospectively investigated BIM deletion polymorphism in NSCLC patients, its correlation with EGFR TKI (erlotinib) resistance, and the mechanism underlying the drug resistance. Among 245 EGFR-mutant NSCLC patients examined, BIM deletion polymorphism was detected in 43 (12...
July 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28767174/inactivation-of-beclin-1-dependent-autophagy-promotes-ursolic-acid-induced-apoptosis-in-hypertrophic-scar-fibroblasts
#7
Chuan Cao, Wenping Wang, Lele Lu, Liang Wang, XiaoSong Chen, Rui Guo, Shirong Li, Junzi Jiang
A hypertrophic scar (HS) is caused by abnormal proliferation of dermal fibroblasts. Thus, promoting hypertrophic scar fibroblast (HSFB) apoptosis is an effective strategy for HS therapy. Ursolic acid (UA) has been widely used as an inducer of apoptosis in diverse cancers. However, whether UA plays an inhibitory role in HS formation is still unknown. In our study, UA was used to treat HSFBs and the cell viability, apoptosis, and collagen synthesis were determined by a Cell Counting Kit 8 (CCK8) assay, flow cytometry, and an H(3) -proline incorporation assay, respectively...
August 2, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28765909/attenuation-of-muc4-potentiates-the-anticancer-activity-of-auranofin-via-regulation-of-the-her2-akt-foxo3-pathway-in-ovarian-cancer-cells
#8
Jun Sang Bae, Jongsung Lee, Yoonkook Park, Kyungmoon Park, Jung Ryul Kim, Dong Hyu Cho, Kyu Yun Jang, See-Hyoung Park
Previously, we reported that auranofin induces apoptosis in SKOV3 cells via regulation of the IKKβ/FOXO3 pathway. In the present study, we reveal that the anticancer activity of auranofin in SKOV3 cells could be enhanced by the attenuation of MUC4 through the regulation of the Her2/Akt/FOXO3 pathway. Compared to the control-siRNA, siRNA transfection against MUC4 into SKOV3 cells accelerated the protein degradation of Her2. Under the same conditions, the expression level of phosphorylated Akt was also downregulated leading to an increase of FOXO3 in the nucleus...
July 28, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28765329/overcoming-acquired-resistance-to-azd9291-a-third-generation-egfr-inhibitor-through-modulation-of-mek-erk-dependent-bim-and-mcl-1-degradation
#9
Puyu Shi, You-Take Oh, Liang Deng, Guojing Zhang, Guoqing Qian, Shuo Zhang, Hui Ren, Grant Wu, Benjamin Legendre, Emily Anderson, Suresh S Ramalingam, Taofeek K Owonikoko, Mingwei Chen, Shi-Yong Sun
<p>The mechanisms accounting for anticancer activity of AZD9291 (osimertinib or TAGRISSO™), an approved third generation EGFR inhibitor, in EGFR-mutant non-small cell lung cancer (NSCLC) cells and particularly for the subsequent development of acquired resistance are unclear and thus are the focus of this study.</p> <br /><br />Experimental Design: <p>AZD9219-resistant cell lines were established by exposing sensitive cell lines to AZD9291. Protein alterations were detected with Western blotting...
August 1, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28765039/jnk1-as-a-signaling-node-in-vdr-braf-induction-of-cell-death-in-aml
#10
Xuening Wang, William K Beute, Jonathan S Harrison, George P Studzinski
Numerous clinical studies of vitamin D, its derivatives or analogs, have failed to clearly demonstrate sustained benefits when used for the treatment of human malignant diseases. However, given the strong preclinical evidence of anti-neoplastic activity and the epidemiological associations suggesting that vitamin D compounds may have a place in cancer therapy, attempts are continuing to devise new approaches to their therapeutic use. This laboratory has developed a strategy to enhance the effectiveness of the currently standard therapy of Acute Myeloid Leukemia (AML) by the immediate addition of the vitamin D2 analog Doxercalciferol combined with the plant polyphenol-derived Carnosic acid to AML cells previously treated with Cytarabine (AraC)...
July 29, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28763128/chemical-tagging-with-t-butyl-and-trimethylsilyl-groups-for-measuring-intermolecular-noes-in-a-large-protein-ligand-complex
#11
Shereen Jabar, Luke Adams, Yao Wang, Luigi Aurelio, Bim Graham, Gottfried Otting
Intermolecular 1H-1H nuclear Overhauser effects (NOE) present a powerful tool to assess contacts between proteins and binding partners, but are difficult to identify for complexes of high molecular weight. We show that intermolecular NOEs can readily be observed following chemical labeling with t-butyl or trimethylsilyl groups. Proteins can be furnished with t-butyl or TMS groups site-specifically using genetically encoded unnatural amino acids or by chemical modification of single cysteine residues. No isotope labeling is required...
August 1, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28762548/health-literacy-cognition-and-urinary-incontinence-among-geriatric-inpatients-discharged-to-skilled-nursing-facilities
#12
Joshua A Cohn, Avantika S Shah, Kathryn M Goggins, Sandra F Simmons, Sunil Kripalani, Roger R Dmochowski, John F Schnelle, William Stuart Reynolds
AIMS: To investigate the association between health literacy and cognition and nursing and patient-reported incontinence in a geriatric inpatient population transitioning to skilled nursing facilities (SNF). METHODS: Health literacy, depression, and cognition were assessed via the Brief Health Literacy Screen (BHLS), Geriatric Depression Scale 5-item (GDS) and Brief Interview for Mental Status (BIMS), respectively. Multivariable logistic regression assessed the association between BHLS score and incontinence by: (1) nursing-reported urinary incontinence during hospitalization; and (2) patient self-reported "bladder accidents" in the post-enrollment study interview...
August 1, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28761429/neuroprotective-effects-of-ganoderma-lucidum-polysaccharides-against-oxidative-stress-induced-neuronal-apoptosis
#13
Xin-Zhi Sun, Ying Liao, Wei Li, Li-Mei Guo
Ganoderma lucidum polysaccharides have protective effects against apoptosis in neurons exposed to ischemia/reperfusion injury, but the mechanisms are unclear. The goal of this study was to investigate the underlying mechanisms of the effects of ganoderma lucidum polysaccharides against oxidative stress-induced neuronal apoptosis. Hydrogen peroxide (H2O2) was used to induce apoptosis in cultured cerebellar granule cells. In these cells, ganoderma lucidum polysaccharides remarkably suppressed H2O2-induced apoptosis, decreased expression of caspase-3, Bax and Bim and increased that of Bcl-2...
June 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28760343/rack1-promotes-radiation-resistance-in-esophageal-cancer-via-regulating-akt-pathway-and-bcl-2-expression
#14
Bowen Liu, Cong Wang, Pengxiang Chen, Lu Wang, Yufeng Cheng
RACK1 is a seven Trp-Asp 40 repeat protein, which interacts with a wide range of kinases and proteins. RACK1 plays an important role in the proliferation and progression of various cancers. The aim of this study is to detect the role of RACK1 in the radioresistance in esophageal cancer. The results indicated that downregulation of RACK1 reduced the colony formation ability, proliferation ability and resistance of cells to radiation effection through regulating the radiation-related proteins including pAKT, Bcl-2 and Bim; whereas upregulation of RACK1 promoted the ability and radioresistance of ESCC cells...
July 28, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28759561/regenerating-family-member-4-reg4-enhances-5-fluorouracil-resistance-of-gastric-cancer-through-activating-mapk-erk-bim-signaling-pathway
#15
Jiaoyue Jin, Hang Lv, Junzhou Wu, Dan Li, Kaiyan Chen, Fanrong Zhang, Jing Han, Jianguo Feng, Nan Zhang, Herbert Yu, Dan Su, Lisha Ying
BACKGROUND Reg4, a member of the Reg multigene family, is highly upregulated in many gastrointestinal cancers including gastric cancer (GC). The enhanced expression of Reg4 is associated with the resistance of GC to 5-fluorouracil (5-FU), while the underlying mechanism is not clear. The aim of the present study was to explore the resistant mechanism underlying 5-FU resistance. MATERIAL AND METHODS Reg4 expression was assessed by Western blot analysis for SGC-7901, BGC-823, AGS, MKN28, and MKN45. Synthetic short single strand RNA oligonucleotides and Flag-Reg4 plasmid were used to investigate the biological function of Reg4 in vitro...
July 31, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28747559/breast-cancer-suppression-by-aplysin-is-associated-with-inhibition-of-pi3k-akt-foxo3a-pathway
#16
Xinling Zhang, Tingting Zhuang, Zhengyan Liang, Li Li, Meilan Xue, Jia Liu, Hui Liang
Aplysin, a bromosesquiterpene isolated from Aplysia kurodai, was explored as a potential anti-breast cancer agent by us. However, the mechanisms underlying the anticarcinogenic effect of aplysin remain unclear. Here, aplysin was found to remarkably suppress tumor growth in vivo, inhibit cell proliferation and promote apoptosis in vitro. Additionally, we demonstrated that aplysin attained these effects in part by down-regulating PI3K/AKT/FOXO3a signaling pathway. Aplysin treatment inhibited the phosphorylation levels of AKT (Ser-473) and AKT-dependent phosphorylation of FOXO3a (Ser-253) in breast cancer cell lines and breast cancer tissues...
July 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28742197/mir-24-alleviates-cardiomyocyte-apoptosis-after-myocardial-infarction-via-targeting-bim
#17
L-J Pan, X Wang, Y Ling, H Gong
OBJECTIVE: Ischemia hypoxia induces cardiomyocyte (CM) apoptosis in the process of acute myocardial infarction (AMI). It was showed that pro-apoptosis factor BIM participates in regulating tumor cell apoptosis under ischemia or hypoxia condition, while its role in CM apoptosis after AMI is still unclear. It was revealed that miR-24 expression was significantly reduced in myocardial tissue after AMI. Bioinformatics analysis exhibits that miR-24 is targeted to the 3'-UTR of BIM. This study aims to investigate the role of miR-24 in mediating BIM expression and CM apoptosis...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28738025/fork-head-box-class-o1-foxo1-activates-bim-expression-to-mediate-cardiac-apoptosis-in-chronic-intermittent-hypoxia-induced-cardiac-hypertrophy
#18
Guangcai Li, Meng Jin, Yuan He, Jie Ren, Minghua Zhang, Yilin Chen, Xiong Lan, Jianhua Zhong, Huiguo Liu
No abstract text is available yet for this article.
July 24, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28726967/unprecedented-ferromagnetic-gdnitronyl-nitroxide-coupling-through-a-hydrogen-bonding-bridge
#19
Juan Sun, Meng Yang, Zan Sun, Xiufeng Wang, Yue Ma, Licun Li
A novel lanthanide(iii)-nitronyl nitroxide chain {[Gd(hfac)3(Nit-Ph-3,5-bIm)(H2O)]·C4H10O}n (1) was prepared and characterized. Strikingly, an unexpected ferromagnetic coupling between the Gd(iii) ion and the nitroxide group mediated by hydrogen bonding has been observed for the first time.
July 20, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28724666/braf-inhibitors-amplify-the-pro-apoptotic-activity-of-mek-inhibitors-by-inducing-er-stress-in-nras-mutant-melanoma
#20
Heike Niessner, Tobias Sinnberg, Corinna Kosnopfel, Keiran S M Smalley, Daniela Beck, Christian Praetorius, Marion Mai, Stefan Beissert, Dagmar Kulms, Martin Schaller, Claus Garbe, Keith T Flaherty, Dana Westphal, Ines Wanke, Friedegund Meier
<p>NRAS mutations in malignant melanoma are associated with aggressive disease requiring rapid antitumor intervention, but there is no approved targeted therapy for this subset of patients. In clinical trials, the MEK inhibitor (MEKi) binimetinib displayed modest antitumor activity, making combinations a requisite. In a previous study, the BRAF inhibitor (BRAFi) vemurafenib was shown to induce endoplasmic reticulum (ER) stress that together with inhibition of the RAF-MEK-ERK (MAPK) pathway amplified its pro-apoptotic activity in BRAF-mutant melanoma...
July 19, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
keyword
keyword
17510
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"