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Yujuan Zhou, Longzheng Xia, Qiang Liu, Heran Wang, Jingguan Lin, Linda Oyang, Xiaoyan Chen, Xia Luo, Shiming Tan, Yutong Tian, Min Su, Ying Wang, Pan Chen, Yang Wu, Hui Wang, Qianjin Liao
BACKGROUND/AIMS: Chronic inflammation plays an important role in the initiation and progression of gastric cancer (GC). However, the role and relationship of activated macrophages with gastric mucous epithelium cells in initiating and maintaining the inflammatory process during gastric carcinogenesis remains unclear. METHODS: The tumour associated macrophages (TAMs) density of gastric cancer was characterized by immunohistochemistry, and the relationship between macrophages and gastric epithelium cells was analysed using an in vitro culture system that imitates the inflammatory microenvironment...
June 19, 2018: Cellular Physiology and Biochemistry
Juan Fernando J Viseu Pinheiro, David P Hernández, Juan Francisco B Blanco
INTRODUCTION: Low back pain is a common cause of medical consultation during pregnancy and usually supposes a non-malignant prognostic. PRESENTATION OF CASES: We report two cases of pregnant women whom suffered cauda equina syndrome during pregnancy and underwent emergency surgery after the birth of their babies. DISCUSSION: MRI is the main diagnosis method for cauda equina even during pregnancy. Modern obstetric practice asks surgeons to perform surgery under safe conditions at all gestation stages...
June 12, 2018: International Journal of Surgery Case Reports
Bénédicte Buffin-Meyer, Julie Klein, Benjamin Breuil, Françoise Muller, Panagiotis Moulos, Marion Groussolles, Ourdia Bouali, Jean-Loup Bascands, Stéphane Decramer, Joost P Schanstra
Most of biomarker panels, extracted from single omics traits, still need improvement since they display a gray zone where prediction is uncertain. Here we verified whether a combination of omics traits, fetal urinary metabolites and peptides analyzed in the same sample, improved prediction of postnatal renal function in fetuses with posterior urethral valves (PUV) compared to individual omics traits. Using CE-MS, we explored the urinary metabolome of 13 PUV fetuses with end stage renal disease (ESRD) and 12 PUV fetuses without postnatal ESRD at 2 years postnatally...
June 18, 2018: Journal of Proteomics
Ke Duan, Zhong-Jian Liu, Su-Qiong Hu, Hong-Yu Huo, Zhi-Ru Xu, Jian-Fei Ruan, Yang Sun, Li-Ping Dai, Chang-Bao Yan, Wei Xiong, Qing-Hua Cui, Hai-Jing Yu, Min Yu, Yang Qin
The Warburg effect is a dominant phenotype of most tumor cells. Recent reports have shown that the Warburg effect can be reprogrammed by the tumor microenvironment. Lactic acidosis and glucose deprivation are the common adverse microenvironments in solid tumor. The metabolic reprogramming induced by lactic acid and glucose deprivation remains to be elucidated in glioblastoma. Here, we show that, under glucose deprivation, lactic acid can preserve high ATP levels and resist cell death in U251 cells. At the same time, we find that MCT1 and MCT4 are significantly highly expressed...
June 18, 2018: Biochemical and Biophysical Research Communications
Jingjing Huang, Tingting Weng, Junsuk Ko, Ning-Yuan Chen, Yu Xiang, Kelly Volcik, Leng Han, Michael R Blackburn, Xiang Lu
BACKGROUND: Non-small cell lung cancer (NSCLC) is a life-threatening disease that has a poor prognosis and low survival rate. Cleavage factor Im 25 (CFIm25) is a RNA-binding protein that if down-regulated causes 3'UTR shortening and thus promotes the transcript stability of target genes. It is not clear whether CFIm25 and alternative polyadenylation (APA) play a role during cancer development. The purpose of this study is to explore the role of CFIm25 in lung cancer cell proliferation...
June 18, 2018: Biochemical and Biophysical Research Communications
Yuan Yuan, Wei Liu, Yangmei Zhang, Youwei Zhang, Sanyuan Sun
Recently, circular RNA (circRNA) is identified as a novel class of noncoding RNA with important roles in human diseases, such as cancer. However, how circRNA participates in colorectal cancer (CRC) remains unclear. In this study, we aimed to illustrate the role of circ_0026344 in CRC progression. We showed that circ_0026344 expression was downregulated in CRC tissues compared to adjacent normal tissues. Moreover, the level of circ_0026344 was inversely correlated with CRC advance and lymphoid node metastasis...
June 18, 2018: Biochemical and Biophysical Research Communications
Qing Ou-Yang, Bing Li, Minhui Xu, Hong Liang
Experimental evidence indicates a critical role of TRPV4 (Transient Receptor Potential Vanilloid 4) in controlling the cell migratory activity of multiple tumors. However, the oncogenic role of TRPV4 in glioma still remains elusive. In this study, we tried to investigate the oncogenic role of TRPV4 in glioma. We found that the expression levels of TRPV4 were upregulated in glioma and the high levels of TRPV4 indicated a worse prognosis in patients with glioma. TRPV4 was critical for glioma migration and invasion: activating TRPV4 by agonist GSK1016790 A enhanced glioma migration and invasion, while, the specific TRPV4 antagonist HC-067047 suppressed glioma migration and invasion...
June 19, 2018: Biochemical and Biophysical Research Communications
Xin Yuan, Bin Li, Hansong Sun, Yan Yang, Hong Meng, Liang Xu, Yunhu Song, Jianping Xu
BACKGROUND: It is uncertain with the outcomes of different repair strategies of anomalous left coronary artery from pulmonary artery (ALCAPA) in adolescent and adult patients. The long-term outcomes of reimplantation and Takeuchi repair were compared in this study. METHODS: We conducted a retrospective review of data collected from patients receiving ALCAPA repair at our institute from January 2005 to December 2016. Short- and long-term outcomes of re-implantation and Takeuchi repair were compared...
June 18, 2018: Annals of Thoracic Surgery
Masamitsu Okada, Satoshi Yamashita, Hidetsugu Ueyama, Masatoshi Ishizaki, Yasushi Maeda, Yukio Ando
Background and purpose: Oxidative stress has been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). Edaravone, a free radical scavenger, was approved as a therapeutic drug for ALS in 2015 in Japan. A phase 3 clinical trial demonstrated a smaller decline in ALS functional scale scores compared with placebo. However, the long-term effects of edaravone on ALS patients remain unclear. This study aimed to retrospectively investigate the long-term effects of edaravone on the survival of ALS patients...
June 2018: ENeurologicalSci
Antoine Schernberg, Alexandre Nivet, Frédéric Dhermain, Samy Ammari, Alexandre Escande, Johan Pallud, Guillaume Louvel, Eric Deutsch
Objective: To study the prognostic value of neutrophil disorders in a retrospective cohort of high-grade glioma patients receiving definitive concurrent temozolomide and radiation. Materials and methods: Clinical records of consecutive patients treated in our Institution between January 2005 and December 2010 with concurrent temozolomide (75 mg/m2 daily) and radiation were collected. The prognostic value of pretreatment neutrophilia on survival, defined as a neutrophil count exceeding 7 G/L, was examined...
March 2018: Clinical and Translational Radiation Oncology
Satoshi Kaneko, Xue Li
Men are much more likely than women to develop bladder cancer (BCa), but the underlying cause of this gender disparity remains poorly defined. Using sex-reversed mice, we show that the sex chromosome complement is an independent cause and, moreover, amplifies the biasing effects of sex hormones. We also show that the X-linked lysine demethylase 6A ( KDM6A ) is a sexually dimorphic gene. Wild-type but not catalytically dead KDM6A confers sustained tumor suppressor activity in vitro. Knockout of mouse Kdm6a reduces expression of Cdkn1a and Perp , canonical gene targets of the tumor suppressor p53 ...
June 2018: Science Advances
Zheng Chen, Gang Zhang, Alexander Lerner, An-Hui Wang, Bo Gao, Jie Liu
Background: The roles of clinical etiology and symptoms, imaging findings and biochemical parameters in predicting the prognosis of posterior reversible encephalopathy syndrome (PRES) have not been well-characterized. We perform a meta-analysis of all published studies to assess the value of various risk factors in predicting the prognosis of PRES. Methods: Searches of the PubMed, EMBASE, Cochrane Library, and Web of Science databases were performed to identify the eligible studies...
May 2018: Quantitative Imaging in Medicine and Surgery
Daniel Jeong, Natarajan Raghunand, Diego Hernando, Michael Poch, Katherine Jeong, Brendan Eck, Jasreman Dhillon
Background: Sarcomatoid differentiation in renal cell carcinoma (sRCC) is histologically characterized by anaplastic changes of renal cell carcinoma (RCC) subtypes, which has been associated with a poor prognosis. sRCC is managed more aggressively than RCC without sarcomatoid components, so pre-operative detection of sarcomatoid differentiation would significantly affect surgical management. The purpose of this study is to compare the quantification of sarcomatoid features in RCCs on pre-operative magnetic resonance imaging (MRI) to standard histological examination...
May 2018: Quantitative Imaging in Medicine and Surgery
Esther Barreiro, Ariel Jaitovich
Patients with chronic obstructive pulmonary disease (COPD) experience several systemic manifestations such skeletal muscle dysfunction with and without muscle mass loss. Moreover, frequent comorbidities such as nutritional abnormalities, heart failure, and pulmonary hypertension, which are frequently associated with COPD may further contribute to skeletal muscle mass loss and dysfunction. Muscle dysfunction impairs the patients' exercise capacity and quality of life as daily life activities may be hampered by this problem...
May 2018: Journal of Thoracic Disease
Joaquim Gea, Antoni Sancho-Muñoz, Roberto Chalela
Nutritional abnormalities are frequent in different chronic respiratory diseases such as chronic obstructive pulmonary disease (COPD), bronchiectasis, cystic fibrosis (CF), interstitial fibrosis and lung cancer, having important clinical consequences. However, nutritional abnormalities often remained underdiagnosed due to the relative lack of awareness of health professionals. Therefore, systematic anthropometry or even better, assessment of body composition, should be performed in all patients with chronic respiratory conditions, especially following exacerbation periods when malnutrition becomes more accentuated...
May 2018: Journal of Thoracic Disease
Kevin B Givechian, Kamil Wnuk, Chad Garner, Stephen Benz, Hermes Garban, Shahrooz Rabizadeh, Kayvan Niazi, Patrick Soon-Shiong
Immune heterogeneity within the tumor microenvironment undoubtedly adds several layers of complexity to our understanding of drug sensitivity and patient prognosis across various cancer types. Within the tumor microenvironment, immunogenicity is a favorable clinical feature in part driven by the antitumor activity of CD8+ T cells. However, tumors often inhibit this antitumor activity by exploiting the suppressive function of regulatory T cells (Tregs), thus suppressing the adaptive immune response. Despite the seemingly intuitive immunosuppressive biology of Tregs, prognostic studies have produced contradictory results regarding the relationship between Treg enrichment and survival...
2018: NPJ Genomic Medicine
Zhixu Chen, Zezheng Liu, Yang Yang, Zhaoyin Zhu, Ridong Liang, Bin Huang, Di Wu, Lei Yang, Hai Lu, Dadi Jin, Qingchu Li
Long non-coding RNAs (lncRNAs) have been shown to exert essential roles in development and progression of tumors. Here we discovered a novel lncRNA, RAB11B antisense RNA (RAB11B-AS1), which is markedly down-regulated in human osteosarcoma (OS) and associated with OS metastasis and poor prognosis. We find that reduction of RAB11B-AS1 significantly facilitates proliferation, migration and invasiveness and prevents apoptosis of OS cells and results in lower sensitivity to cisplatin in these cells. In contrast, up-regulation of RAB11B-AS1 suppresses the aggressive behaviors of OS cells...
June 1, 2018: Oncotarget
Jatinder K Lamba, Xueyuan Cao, Susana C Raimondi, Roya Rafiee, James R Downing, Shi Lei, Tanja Gruber, Raul C Ribeiro, Jeffrey E Rubnitz, Stanley B Pounds
Acute myeloid leukemia (AML) may be an epigenetically-driven malignancy because it harbors fewer genomic mutations than other cancers. In recent studies of AML in adults, DNA methylation patterns associate with clinical risk groups and prognosis. However, thorough evaluations of methylation in pediatric AML have not been done. Therefore, we performed an integrated analysis (IA) of the methylome and transcriptome with clinical outcome in 151 pediatric patients from the multi-center AML02 clinical trial discovery cohort...
June 1, 2018: Oncotarget
Hideo Shigematsu, Shinji Ozaki, Daisuke Yasui, Hideki Yamamoto, Junichi Zaitsu, Daiki Taniyama, Akihisa Saitou, Kazuya Kuraoka, Taizo Hirata, Kiyomi Taniyama
Background: The prognostic value and the best method of testing of topoisomerase II alpha (TOP2A) status have not been established in modern tailored therapy based on breast cancer subtype. Results: The frequencies of TOP2A overexpression and TOP2A amplified were 55.8% and 9.5%, respectively. TOP2A overexpression correlated strongly with non-luminal A subtype (χ2 -test, p < 0.001). TOP2A overexpression was significantly associated with relapse-free survival in luminal B breast cancer ( n = 316; log rank test, p < 0...
June 1, 2018: Oncotarget
Yasutaka Yamada, Takayuki Arai, Satoko Kojima, Sho Sugawara, Mayuko Kato, Atsushi Okato, Kazuto Yamazaki, Yukio Naya, Tomohiko Ichikawa, Naohiko Seki
Recent studies revealed that some passenger strands of miRNAs acted as anti-tumor or oncogenic miRNAs in cancer cells. In this study, we focused on miR-455-5p (the passenger strand) and miR-455-3p (the guide strand) based on microRNA (miRNA) expression signatures of cancer cells. Both miR-455-5p and miR-455-3p were downregulated in renal cell carcinoma (RCC) tissues and low expression of these miRNAs was significantly associated with poor prognosis. Cancer cell proliferation, migration and invasive abilities were significantly inhibited by ectopic expression of miR-455-5p and miR-455-3p ...
June 1, 2018: Oncotarget
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