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https://www.readbyqxmd.com/read/29679654/the-vanillin-derivative-6-bromine-5-hydroxy-4-methoxybenzaldehyde-induces-aberrant-mitotic-progression-and-enhances-radio-sensitivity-accompanying-suppression-the-expression-of-plk1-in-esophageal-squamous-cell-carcinoma
#1
Meng-Meng Gu, Ming Li, Dexuan Gao, Lang-Huan Liu, Yue Lang, Si-Ming Yang, Hongling Ou, Bo Huang, Ping-Kun Zhou, Zeng-Fu Shang
Esophageal squamous cell carcinoma (ESCC) is the most common form of esophageal cancer in China. Since chemotherapy is the standard clinical intervention for advanced ESCC, the development of highly effective and minimal/non-toxic drugs is essential to improve the clinical outcome and prognosis of the patients. A novel derivative of vanillin, 6-bromine-5-hydroxy-4-methoxybenzaldehyde (BVAN08), has been recently reported to activate different cell death pathways in cancer cells. In this study, we demonstrate that BVAN08 exhibits a potent anti-proliferation effect on ESCC cells (TE-1 and ECA-109) by inhibiting the expression of PLK1, an important mitotic kinase...
April 18, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29679610/mutated-mitf-e87r-in-melanoma-enhances-tumor-progression-via-s100a4
#2
Alice Nordlinger, Shani Dror, Abdel Elkahloun, Justine Del Rio, Elisa Stubbs, Tami Golan, Hagar Malcov, Todd D Pricket, Julia C Cronin, Shivang Parikh, Sapir Labes, Laetitia Thomas, Gal Yankovitz, Yuval Tabach, Carmit Levy, Yardena Samuels, Mehdi Khaled
Melanoma, a melanocyte origin neoplasm, is the most lethal type of skin cancer and incidence is increasing. Several familial and somatic mutations have been identified in the gene encoding the melanocyte lineage master regulator, microphthalmia-associated transcription factor (MITF); however, the neoplastic mechanisms of these mutant MITF variants are mostly unknown. Here, by performing unbiased analysis of the transcriptomes in cells expressing mutant MITF, we identified calcium-binding protein S100A4, as a downstream target of MITF-E87R...
April 18, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29679605/circulating-cell-free-dna-in-patients-with-alveolar-echinococcosis
#3
Alice Baraquin, Eric Hervouet, Carine Richou, Pierre Flori, Paul Peixoto, Amel Azizi, Eric Delabrousse, Oleg Blagosklonov, Gerald Umhang, Solange Bresson-Hadni, Benoit Valot, Frédéric Grenouillet
Alveolar echinococcosis (AE) is a parasitic disease, due to Echinococcus multilocularis. Often compared to liver cancer, it develops by infiltration from its primary site to the surrounding tissue, and can then metastasize to other organs. Detection of circulating cell-free DNA (ccfDNA) is a useful analytical tool in oncology, for diagnosis, prognosis, and therapy monitoring. This study sought to investigate the presence of ccfDNA in patients with AE, and its potential usefulness for the evaluation of treatment efficiency...
April 18, 2018: Molecular and Biochemical Parasitology
https://www.readbyqxmd.com/read/29679556/a-novel-smac-mimetic-apg-1387-exhibited-dual-antitumor-effect-on-hbv-positive-hepatocellular-carcinoma-with-high-expression-of-ciap2-by-inducing-apoptosis-and-enhancing-innate-anti-tumor-immunity
#4
Wentao Pan, Qiuyun Luo, Xianglei Yan, Luping Yuan, Hanjie Yi, Lin Zhang, Baoxia Li, Yuxin Zhang, Jian Sun, Miao-Zhen Qiu, Da-Jun Yang
Check point inhibitor anti-PD1 antibody produced some efficacy in Hepatocellular Carcinoma (HCC) patients previously treated with sorafenib. Unfortunately, HCC patients with hepatitis B virus (HBV) infection did not respond as well as uninfected patients. Previously, SMAC mimetics-the antagonist for inhibitor of apoptosis proteins (IAPs) can rapidly reduce serum hepatitis B virus DNA in animal model. APG-1387 is a novel SMAC-mimetic, small molecule inhibitor targeting inhibitor of apoptosis proteins (IAPs)...
April 18, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29679404/paranasal-sinus-cysts-in-the-horse-complications-related-to-their-presence-and-surgical-treatment-in-37-cases
#5
M F Fenner, D Verwilghen, N Townsend, H Simhofer, J Schwarzer, D D Zani, A Bienert-Zeit
BACKGROUND: Paranasal sinus cysts (PSC) are a common cause of equine secondary sinusitis. The outcome and associated complications have not been frequently reported. OBJECTIVES: To review the associated clinical signs, associated morbidities and outcomes of horses treated for PSC. STUDY DESIGN: Retrospective multicentre case series. METHODS: Retrospective analysis of case records and telephone follow up survey. RESULTS: Subjects were 37 horses 1 to 24 years old that were presented with nasal discharge (n = 31), facial swelling (n = 25) and epiphora (n = 19)...
April 20, 2018: Equine Veterinary Journal
https://www.readbyqxmd.com/read/29679238/identification-of-subsets-of-actionable-genetic-alterations-in-kras-mutant-lung-cancers-using-association-rule-mining
#6
Junior Tayou
BACKGROUND: Lung cancer is the leading cause of cancer-related death in both men and women. KRAS mutations occur in ~ 25% of patients with lung cancer, and the presence of these mutations is associated with a poor prognosis. Unfortunately, efforts to directly target KRAS or its associated downstream MAPK or PI3K/AKT/mTOR pathways have seen little or no benefits. Here, I hypothesize that KRAS-mutant tumors do not respond to KRAS pathway therapies due to the co-occurrence of other activated cell survival pathways and/or mechanisms...
April 20, 2018: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/29679199/-18-f-fdopa-pet-and-mri-characteristics-correlate-with-degree-of-malignancy-and-predict-survival-in-treatment-na%C3%A3-ve-gliomas-a-cross-sectional-study
#7
Chirag B Patel, Elisa Fazzari, Ararat Chakhoyan, Jingwen Yao, Catalina Raymond, Huytram Nguyen, Jasmine Manoukian, Nhung Nguyen, Whitney Pope, Timothy F Cloughesy, Phioanh L Nghiemphu, Johannes Czernin, Albert Lai, Benjamin M Ellingson
INTRODUCTION: To report the potential value of pre-operative 18 F-FDOPA PET and anatomic MRI in diagnosis and prognosis of glioma patients. METHODS: Forty-five patients with a pathological diagnosis of glioma with pre-operative 18 F-FDOPA PET and anatomic MRI were retrospectively examined. The volume of contrast enhancement and T2 hyperintensity on MRI images along with the ratio of maximum 18 F-FDOPA SUV in tumor to normal tissue (T/N SUVmax ) were measured and used to predict tumor grade, molecular status, and overall survival (OS)...
April 20, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29679194/posterior-cranial-fossa-and-spinal-local-infections
#8
Federico Bianchi, Gianpiero Tamburrini
OBJECT: The aim of this paper is to review the current knowledge on the management of local infections in posterior cranial fossa (PCF) and spinal surgery; the center of our paper will be the diagnosis and management of infections of the wound, the subcutaneous tissue, and muscle strata. RESULTS AND CONCLUSIONS: Very few papers address the problem of local infections in posterior cranial fossa and spinal surgery. The largest amount of the literature data is indeed centered on how to deal with deep infections, CSF leak, and secondary meningitis or hardware infection...
April 20, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29679177/impact-of-the-number-of-removed-lymph-nodes-on-recurrence-free-survival-in-stage-i-ovarian-clear-cell-carcinoma
#9
Yuji Takei, Suzuyo Takahashi, Shizuo Machida, Akiyo Taneichi, Takahiro Yoshiba, Yoshifumi Takahashi, Chikako Yoshida, Yasushi Saga, Shigeki Matsubara, Hiroyuki Fujiwara
BACKGROUND: Although there have been several reports regarding the significance of staging lymphadenectomy for early stage ovarian clear cell carcinoma (CCC) patients, there have been few reports focusing on the number of removed lymph nodes. The aim of this study was to evaluate the impact of the number of removed lymph nodes on recurrence-free survival (RFS) in stage I ovarian CCC. METHODS: The subjects were patients with ovarian CCC who underwent surgery between January 1988 and December 2013...
April 20, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29679150/ten-year-comparative-analysis-of-incidence-prognosis-and-associated-factors-for-dialysis-and-renal-transplantation-in-type-1-and-type-2-diabetes-versus-non-diabetes
#10
Carlo Bruno Giorda, Paolo Carnà, Mario Salomone, Roberta Picariello, Giuseppe Costa, Barbara Tartaglino, Roberto Gnavi
AIMS: To study the incidence of and the factors associated with renal dialysis and transplantation in type 1 (T1DM) and type 2 diabetes (T2DM). METHODS: Data on individuals who had received dialysis treatment or renal transplant between 1 January 2004 and 31 December 2013 were extracted from the regional administrative database (Piedmont, Italy), and the crude (cumulative) incidence of dialysis was calculated. Overall cumulative survival was estimated using the Kaplan-Meier method and compared using the log-rank test...
April 20, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29678898/significance-of-aquaporin-aqps-expression-in-the-prognosis-of-gastric-cancer
#11
Saroj Thapa, Mandika Chetry, Kaiyu Huang, Yangpei Peng, Jinsheng Wang, Jiaoni Wang, Yingying Zhou, Yigen Shen, Yangjing Xue, Kangting Ji
Gastric carcinoma is one of the most lethal malignancy at present with leading cause of cancer-related death worldwide. Aquaporins (AQPs) are  family of small, integral membrane proteins, which have been evidenced to play a crucial role in cell migration and proliferation of different cancer cells including gastric cancers. However, the aberrant expression of specific AQPs and its correlation to detect predictive and prognostic significance in gastric cancer remains elusive. In the present study, we comprehensively explored immunohistochemistry based map of protein expression profiles in normal tissues, cancer and cell lines from publicly available Human Protein Atlas database...
April 20, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29678851/improved-diagnostic-and-prognostic-power-of-combined-delta-neutrophil-index-and-mean-platelet-volume-in-pediatric-sepsis
#12
Minjeong Nam, Byeong Hei Son, Jung Eun Seo, Il Ry Kim, Chee Kyoung Park, Hyun Kyung Kim
This study aims to evaluate the diagnostic and prognostic significance of white blood cell (WBC) and platelet parameters measured by automated hematology analyzers in pediatric sepsis. The study included 232 pediatric patients whose C-reactive protein test had been requested for evaluation of infection or inflammation at a pediatric tertiary hospital. The patients were allocated to control, systemic inflammatory response syndrome (SIRS) without infection, and sepsis groups. An ADVIA 2120i hematology system was used to measure the delta neutrophil index (DN) and platelet parameters including platelet count, mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT), and immature platelet fraction (IPF)...
March 2018: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/29678709/metastatic-non-gestational-choriocarcinoma-to-the-brain-a-case-report-and-proposed-treatment-recommendations
#13
Jason Duong, Hammad Ghanchi, Dan Miulli, Avneet Kahlon
OBJECTIVE: Non-gestational choriocarcinoma (NGC) is a rare germ cell tumor, reported less than 0.6% of all gestational tumors, and has a poor prognosis when metastasized. NGC is even less reported with metastasis to the brain. Gestational choriocarcinoma (GC) when metastasized to the brain has a higher morbidity and mortality but has been known to be a chemosensitive and radiosensitive lesion, and NGC is chemoresistant with an even worse prognosis. Currently, there is no consensus for treatment for metastatic NGC to the brain...
April 17, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29678637/is-the-occlusion-site-of-the-lenticulostriate-artery-identified-on-admission-related-to-clinical-prognosis-in-patients-with-lacunar-stroke
#14
Masaki Naganuma, Yuichiro Inatomi, Makoto Nakajima, Takeshi Ohta, Toshiro Yonehara, Yukio Ando
BACKGROUND: The mechanism of lacunar stroke (LS) is rather speculative due to the lack of neuropathological evidence in clinical practice. To explore the significance of the occlusion site of the lenticulostriate artery (LSA) to this mechanism, we investigated the characteristics and prognosis of patients with LS with proximal occlusions. MATERIALS AND METHODS: We studied 202 patients with acute LS in the region of the LSA. The presumed occlusion site of the LSA was assessed on coronal, diffusion-weighted magnetic resonance images...
April 17, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29678634/the-prognostic-value-of-hoxa13-in-solid-tumors-a-meta-analysis
#15
REVIEW
Yaoan Wen, Fangpeng Shu, Yeda Chen, Yiwen Chen, Yu Lan, Xiaolu Duan, Shan-Chao Zhao, Guohua Zeng
PURPOSE: The prognostic value of homeobox (HOX) A13 (HOXA13) in cancer remains uncertain due to limitations of sample size and discrete outcome in previous studies. We performed this meta-analysis to explore the prognostic effect of HOXA13 in patients with solid tumors. METHODS: PubMed, Embase, and Web of Science were searched to identify eligible studies. Hazard ratios (HR) with 95% confidence interval (95%CI) and clinicopathological factors were extracted. Subgroup analysis according to cancer type, sample size and analysis method were also performed...
April 17, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29678584/genome-wide-profiles-of-metastasis-associated-mrnas-and-micrornas-in-salivary-adenoid-cystic-carcinoma
#16
Shubin Wang, Lei Zhang, Pengwei Shi, Yuanyuan Zhang, Hong Zhou, Xuanping Cao
Salivary adenoid cystic carcinoma (SACC) is often accompanied with poor prognosis due to local recurrence, distant metastasis, and perineural invasion. The mechanism involved in SACC metastasis is not yet fully understood. In this study, we profiled the expression of messenger RNA (mRNA) and microRNA (miRNA) in an SACC cell line, ACC-2, and a highly metastatic SACC cell line, ACC-M, using high-throughput sequencing. We discovered that: (1) differentially expressed (DE) mRNAs and DE miRNAs are potentially involved in SACC metastasis; (2) multiple regulatory interactions between DE miRNAs and DE mRNAs exist; and (3) miR-338-5p/3p target LAMC2 to impair motility and invasion of ACC-M and MDA-MB-231 cells...
April 17, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29678527/the-effect-of-neoadjuvant-androgen-deprivation-therapy-on-tumor-hypoxia-in-high-grade-prostate-cancer-an-18-f-miso-pet-mri-study
#17
Ismini C Mainta, Thomas Zilli, Jean-Christophe Tille, Thomas De Perrot, Jean-Paul Vallée, Franz Buchegger, Valentina Garibotto, Raymond Miralbell
PURPOSE: Tumor hypoxia is associated with radioresistance and poor prognosis after radiation therapy for prostate cancer (PCa). In this prospective pilot study, we assessed the ability of 18 F-misonidazole (18 F-MISO) positron emission tomography (PET)-magnetic resonance imaging (MRI) to detect hypoxia in high-grade PCa patients who were candidates for curative radiation therapy, and we evaluated 18 F-MISO PET-MRI modulation after 3 months of neoadjuvant androgen deprivation therapy (nADT)...
March 8, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29678488/medicolegal-considerations-involving-iatrogenic-lingual-nerve-damage
#18
REVIEW
Roberto Pippi, Andrea Spota, Marcello Santoro
The aim of this review is to improve risk management strategies through analysis of the anatomic, semeiotic, and medicolegal aspects that characterize iatrogenic lingual nerve damage (LND) and its legal consequences in the case of legal proceedings for a claim for compensation. In dental practice, LND can be caused by local or general anesthesia or by mechanical, chemical, or thermal mechanisms. A certain postoperative identification of LND etiopathogenesis is often very challenging because it can be difficult to show at what time the damage occurred and which mechanism actually caused it...
March 27, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29678294/association-between-body-mass-index-and-clinical-outcomes-of-patients-after-cardiac-arrest-and-resuscitation-a-meta-analysis
#19
REVIEW
Ye Ma, Lili Huang, Lu Zhang, Hai Yu, Bin Liu
BACKGROUND: Obesity as one of the risk factors for cardiovascular diseases increases mortality in general population. Several clinical studies investigated clinical outcomes in patients with different body mass index (BMI) after cardiac arrest (CA). Controversial data regarding BMI on clinical outcomes in those patients exist in those studies. Therefore, we conducted a meta-analysis to evaluate the effect of BMI on survival condition and neurological prognosis in those patients. METHODS: We searched Pubmed, Embase, Ovid/Medline and EBM reviews databases for relational studies investigating the association between BMI and clinical outcomes of patients after CA...
April 6, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29678257/-functional-status-as-an-independent-risk-factor-in-elderly-patients-admitted-to-an-intensive-care-unit
#20
Federico Gordo, Cristina Castro, Inés Torrejón, Sonia Bartolomé, Francisco Coca, Ana Abella
OBJECTIVE: To assess the association of previous functional status in elderly patients admitted to the ICU, estimated by the Barthel and Short Form-Late Life Function and Disability instrument scales, and the relationship with prognosis and functional capacity at hospital discharge. MATERIAL AND METHODS: Observational prospective study of ICU-admitted patients older than 74 years, with a length of stay greater than 48hours. Demographic data, social background, comorbidities, disability questionnaire (Barthel, Short Form-Late Life Function and Disability instrument), main diagnosis and severity (SAPS 3) on ICU admission were recorded...
April 17, 2018: Revista Española de Geriatría y Gerontología
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