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chronic sinusitis and treatment

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https://www.readbyqxmd.com/read/29783264/the-use-of-immunohistochemical-methods-in-the-study-of-morphofunctional-features-of-the-human-paranasal-sinuses-literature-review
#1
Mykhailo M Koptev, Nataliia I Vynnyk, Oksana V Kokovska, Olena М Pronina, Serhii М Bilash
OBJECTIVE: Introduction:Chronic inflammatory diseases of the mucous membrane of the nose, paranasal sinuses, and pharynx are the most widespread pathology of the upper airways. The thorough study of the features of the organization of local immune protection of the mucous membrane of the paranasal sinuses is crucial for the deep understanding of the causes of the onset and development of this and other pathologies of the paranasal sinuses, the choice of methods of diagnostics and treatment...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29782068/comparison-of-outcomes-following-culture-directed-vs-non-culture-directed-antibiotics-in-treatment-of-acute-exacerbations-of-chronic-rhinosinusitis
#2
Carol H Yan, Navarat Tangbumrungtham, Ximena A Maul, Yifei Ma, Jayakar V Nayak, Peter H Hwang, Zara M Patel
BACKGROUND: Acute exacerbations in patients with chronic rhinosinusitis (CRS) are often treated with courses of systemic antibiotics. Poor correlation between microbiologic culture results and the sinus microbiome in CRS has caused increased debate as to the relevance of culture-directed antibiotics. There is currently sparse data comparing outcomes of culture-directed antibiotics vs non-culture-directed antibiotics for treatment of CRS. METHODS: This work reports a retrospective review...
May 21, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29781286/medical-therapy-versus-balloon-sinus-dilation-in-adults-with-chronic-rhinosinusitis-merlot-12-month-follow-up
#3
J Pablo Stolovitzky, Neelesh Mehendale, Keith E Matheny, William J Brown, Anthony A Rieder, Douglas R Liepert, Ewen Tseng, Andrew Gould
Background Chronic rhinosinusitis (CRS) is a devastating disease affecting nearly 30 million people in the United States. An interim analysis of data from the present study suggested that, in patients who had previously failed medical therapy, balloon sinus dilation (BSD) plus medical management (MM) provides a significant improvement in the quality of life (QOL) at 24 weeks postprocedure compared to MM alone. Objective The primary objective of this final analysis was to evaluate the durability of treatment effects through the 52-week follow-up...
January 1, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29777294/impact-of-residual-frontal-recess-cells-on-frontal-sinusitis-after-endoscopic-sinus-surgery
#4
Tsuguhisa Nakayama, Daiya Asaka, Akihito Kuboki, Tetsushi Okushi, Hiromi Kojima
PURPOSE: Endoscopic sinus surgery (ESS) is a well-established treatment for chronic rhinosinusitis (CRS). However, ESS for frontal sinusitis remains complicated and challenging. The aim of this study was to identify the relationship between residual frontal recess cells and primary ESS failure in the frontal sinus. METHODS: We prospectively collected information on 214 sides of 129 patients with CRS who underwent standard ESS from June 2010 to May 2011. To identify risk factors, we retrospectively analyzed clinical data and computed tomography (CT) images before and 3 months after surgery...
May 18, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29776425/combined-application-of-latissimus-dorsi-myocutaneous-flap-and-iliac-bone-flap-in-the-treatment-of-chronic-osteomyelitis-of-the-lower-extremity
#5
Jihui Ju, Lei Li, Rong Zhou, Ruixing Hou
BACKGROUND: To evaluate the clinical efficacy and safety of latissimus dorsi myocutaneous flap (stage I) combined with iliac bone flap (stage II) in the treatment of chronic osteomyelitis of the lower extremity. METHODS: Clinical data of 18 patients undergoing latissimus dorsi myocutaneous flap in combination with iliac bone flap grafting were retrospectively analyzed. Among them, 2 patients developed chronic osteomyelitis of the lower segment of the femur, 4 were diagnosed with chronic osteomyelitis of the tibial plateau, and 12 with chronic osteomyelitis of the lower segment of the tibia...
May 18, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29775027/-clinical-research-of-different-characteristics-of-fungal-ball-sinusitis
#6
M J Wang, B Zhou, Y C Li, S J Cui, Q Huang
Objective: The aim of this study is to investigate the clinical features of different subtypes of fungal ball sinusitis. Method: Four hundred and forty-nine cases with fungal ball rhinosinusitis (FBS) were involved in this retrospective analysis. The clinical features including symptoms, signs, and imaging scans, pathological results were all collected for each patient and the patients were classified into different subtypes according to these clinical features and the follow-up treatment. Result: In this retrospective study, 449 patients who diagnosed with fungal ball sinusitis were involved...
February 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29771095/-a-progress-of-macrolides-therapy-for-chronic-rhinosinusitis
#7
REVIEW
S Shen, C S Wang
Macrolides are a type of antibiotics with macrocyclic lactone ring, which have been commonly used in the treatment of diffuse panbronchiolitis, chronic obstructive pulmonary disease, bronchial asthma, cystic fibrosis and other diseases. Macrolides not only have effect on antibacterial, but also effect on anti-inflammatory and immunoregulation. Chronic rhinosinusitis (CRS) is a common disease entity of infectious and inflammatory diseases that involved in nasal cavity and nasal sinuses, with various clinical phenotypes...
May 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29762337/real-life-indications-to-ivabradine-treatment-for-heart-rate-optimization-in-patients-with-chronic-systolic-heart-failure
#8
Lara Tondi, Gabriele Fragasso, Roberto Spoladore, Giuseppe Pinto, Marco Gemma, Massimo Slavich, Cosmo Godino, Anna Salerno, Claudia Montanaro, Alberto Margonato
: Ivabradine is a selective and specific inhibitor of If current. With its pure negative chronotropic action, it is recommended by European Society of Cardiology and American College of Cardiology/American Heart Association guidelines in symptomatic heart failure patients (NYHA ≥ 2) with ejection fraction 35% or less, sinus rhythm and heart rate (HR) at least 70 bpm, despite maximally titrated β-blocker therapy. Data supporting this indication mainly derive from the SHIFT study, in which ivabradine reduced the combined endpoint of mortality and hospitalization, despite the fact that only 26% of patients enrolled were on optimal β-blocker doses...
May 11, 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29762331/rare-location-for-pilonidal-sinus-the-nasal-dorsum
#9
Ayhan Kars, Fatma Atalay, Korhan Kilic, Fatih Bingöl, Yusuf Can
Pilonidal sinuses are recurrent chronic inflammatory lesions which may occur due to penetration of hair particles into skin. Herein, the authors report a pilonidal sinus case that is unusually seen on nasal dorsum and totally excised with the open technique rhinoplasty method. A 20-year-old male patient was admitted to the authors' outpatient clinic with complaints of dysmorphism and discharge from nasal dorsum. Physical examination revealed a swelling in nasal dorsum and hair-containing fistula. Excision was performed with an open rhinoplasty approach...
May 14, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29759032/tim-3-expressing-mast-cells-are-present-in-chronic-rhinosinusitis-with-nasal-polyps
#10
Erica Corredera, Binh L Phong, John A Moore, Lawrence P Kane, Stella E Lee
Objectives To identify whether TIM-3 expression is present in the mast cell population within nasal polyps and to determine its correlation with clinical severity in patients with chronic rhinosinusitis with nasal polyposis. Study Design Basic science, translational study. Setting Nasal polyp tissue collected from patients seen at a tertiary care hospital (2015-2016). Subjects and Methods Nasal polyp tissue obtained during functional endoscopic sinus surgery (n = 24) was enzymatically digested into epithelial and stromal fractions...
May 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29755837/chagasic-cardiomyopathy-and-pompe-disease-case-report
#11
Rafael Ob de Morais, Ândrea V Chaves-Markman, Anna Pp Miranda, Ingrid G Amorim, Maria da Ga de M Cavalcanti, Manuel Markman, Brivaldo Markman-Filho
BACKGROUND: Pompe disease is a lysosomal storage disease with an autosomal recessive inheritance characterized by an insufficient activity of the acid alpha-glucosidase enzyme. The incidence varies from 1:40000 to 1:200000 live births and cardiac involvement in adults is rare. Chagas disease is an infection caused by the protozoan Trypanosoma cruzi, in which one-third of the cases progress to the chronic form, and may lead to cardiac involvement, usually from the fifth decade of life onwards...
2018: American Journal of Cardiovascular Disease
https://www.readbyqxmd.com/read/29746460/a-holistic-approach-to-the-mycetoma-management
#12
Sahar Mubarak Bakhiet, Ahmed Hassan Fahal, Ahmed Mudawi Musa, El Samani Wadaa Mohamed, Rowa Fathelrahman Omer, Eiman Siddig Ahmed, Mustafa El Nour, El Rayah Mohamed Mustafa, Manar El Sheikh A Rahman, Suliman Hussein Suliman, Mohamed A Gadir El Mamoun, Hajo Mohamed El Amin
Mycetoma, one of the badly neglected tropical diseases, it is a localised chronic granulomatous inflammatory disease characterised by painless subcutaneous mass and formation of multiple sinuses that produce purulent discharge and grains. If untreated early and appropriately, it usually spread to affect the deep structures and bone resulting in massive damage, deformities and disabilities. It can also spread via the lymphatics and blood leading to distant secondary satellites associated with high morbidity and mortality...
May 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29745260/nasopharyngeal-rhinosporidiosis-with-intracranial-extension-masquerading-as-juvenile-angiofibroma-an-unusual-entity
#13
Gautam Dutta, Ghanshyam D Singhal, Daljit Singh, Hukum Singh, Arvind Kumar Srivastava, Anita Jagetia
Rhinosporidiosis is a chronic fungal inflammatory disease prevalent in India and Sri Lanka. Its manifestations are mostly nasal and extranasal lesions are relatively rare. Occasional atypical presentations of this disease lead to diagnostic dilemma. Herein we report on a case of nasopharyngeal rhinosporidiosis having extensive involvement of paranasal sinuses along with intracranial extension which mimicked radiologically as juvenile nasopharyngeal angiofibroma. To our knowledge, this is the first reported case of rhinosporidiosis having intracranial extension...
May 10, 2018: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29741096/clinical-predictors-of-frontal-ostium-restenosis-after-draf-3-procedure-for-refractory-chronic-rhinosinusitis
#14
Xiaoqing Zhang, Ting Ye, Zhenxiao Huang, Qian Huang, Junfang Xian, Jing Li, Bing Zhou
Background The Draf 3 procedure has been demonstrated to be effective in the treatment of refractory frontal sinus disease. A variety of clinical factors may contribute to the change of frontal neo-ostium (FNO) area after this procedure. Imaging plays a vital role in the evaluation and follow-up after surgery and provides useful prognostic information. Objectives (1) To investigate the influence of local anatomic factors on FNO after a Draf 3 procedure by radiological measurements on imaging software and (2) to explore other predictive factors of FNO restenosis...
January 1, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29737747/-efficacy-analysis-on-pediatric-balloon-sinuplasty-via-intubation-in-the-treatment-of-chronic-maxillary-sinusitis-of-98-cases
#15
Jian Qiao Jiang, Xiang Yang Shi, Xue Juan Zhang
No abstract text is available yet for this article.
March 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29731100/endotype-driven-care-pathways-in-patients-with-chronic-rhinosinusitis
#16
REVIEW
Claus Bachert, Nan Zhang, Peter W Hellings, Jean Bousquet
Chronic rhinosinusitis (CRS) has been differentiated clinically into CRS without nasal polyps and CRS with nasal polyps, with both forms subjected to glucocorticosteroid and antibiotic treatments and, if not successful, to nasal and sinus surgery tailored to endoscopic and computed tomographic scan findings. The elaboration of endotypes based on pathomechanisms involving different immune responses offers new possibilities in terms of prediction of prognosis and risks and sophisticated guidance in personalized pharmacotherapy, surgical approaches, and innovative treatment approaches in the CRS field with various biologics...
May 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29719139/establishing-the-minimal-clinically-important-difference-for-the-questionnaire-of-olfactory-disorders
#17
Jose L Mattos, Rodney J Schlosser, Jess C Mace, Timothy L Smith, Zachary M Soler
BACKGROUND: Olfactory-specific quality of life (QOL) can be measured using the Questionnaire of Olfactory Disorders Negative Statements (QOD-NS). Changes in the QOD-NS after treatment can be difficult to interpret since there is no standardized definition of clinically meaningful improvement. METHODS: Patients with chronic rhinosinusitis (CRS) completed the QOD-NS. Four distribution-based methods were used to calculate the minimal clinically important difference (MCID): (1) one-half standard deviation (SD); (2) standard error of the mean (SEM); (3) Cohen's effect size (d) of the smallest unit of change; and (4) minimal detectable change (MDC)...
May 2, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29713735/a-new-oval-advancement-flap-design-for-reconstruction-of-pilonidal-sinus-defect
#18
Enver Arpaci, Serdar Altun, Erkan Orhan, Atilla Eyuboglu, Nilgun Markal Ertas
BACKGROUNDS: Pilonidal sinus is a common chronic disease of the sacrococcygeal region. Although many surgical methods have been described for treating pilonidal sinus disease, controversy still exists as to the best surgical technique. The aim of this study is to present a new modified advancement flap technique named "omega flap" for the treatment of pilonidal sinus disease. MATERIALS AND METHODS: This study included 18 patients with pilonidal sinus who were treated between March 2012 and August 2014...
April 30, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29709603/photodynamic-therapy-for-hidradenitis-suppurativa-acne-inversa-case-report
#19
Yunjie Zhang, Yuguang Yang, Xianbiao Zou
Hidradenitis suppurativa/acne inversa (HS/AI) is a type of chronic suppurative inflammatory reaction of the hair follicles characterized by recurrent dermal abscesses, sinus tracts and scars. So far, there has not been any prospective study proving the efficacy and safety of photodynamic therapy for the disease. In this report, one case of HS/AI achieved resolution of skin lesions, ulcer healing and disappearance of symptoms after nine treatments with 5-aminolevulinic acid photodynamic therapy (ALA-PDT).
April 27, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29707473/hemangioma-of-the-cavernous-sinus-a-case-series
#20
Dylan A Noblett, Jennifer Chang, Atrin Toussi, Arthur Dublin, Kiarash Shahlaie
Introduction  Cavernous sinus hemangiomas (CSHs) are rare, vascular, extra-axial tumors that are diagnosed with a combination of imaging and biopsy. We describe the clinical presentations, imaging findings, and management of two male patients with CSHs. Case Report  Case 1 describes a 57-year-old man who presented with vision changes and cranial nerve palsies. Initial imaging and surgical biopsy were nondiagnostic. Follow-up Tc-99m tagged red blood cell (RBC) imaging supported CSH diagnosis. He was treated with surgical resection and radiotherapy...
April 2018: Journal of Neurological Surgery Reports
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